
PMC:1892049 / 4453-6058
Annnotations
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T6046 | 86-92 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | mutant |
T6047 | 97-102 | NCBITaxon:10088 | denotes | mouse |
T6048 | 189-196 | SO_EXT:0000704 | denotes | genetic |
T6049 | 246-254 | SO:0001817 | denotes | in-frame |
T6050 | 255-263 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
T6051 | 267-272 | SO_EXT:0000147 | denotes | exons |
T6052 | 290-294 | SO_EXT:0000704 | denotes | gene |
T6053 | 295-300 | PR_EXT:000009158 | denotes | Itpr1 |
T6054 | 302-307 | PR_EXT:000009158 | denotes | Itpr1 |
T6055 | 318-326 | SO_EXT:sequence_coding_function | denotes | encoding |
T6056 | 327-354 | CHEBI_EXT:1D_myo_inositol_1_4_5_trisphosphate | denotes | inositol 1,4,5-triphosphate |
T6057 | 327-363 | GO_EXT:0005220 | denotes | inositol 1,4,5-triphosphate receptor |
T6058 | 327-365 | PR_EXT:000009158 | denotes | inositol 1,4,5-triphosphate receptor 1 |
T6059 | 367-372 | PR_EXT:000009158 | denotes | Itpr1 |
T6060 | 393-398 | SO_EXT:0000147 | denotes | exons |
T6061 | 403-425 | SO_EXT:0001421 | denotes | intron–exon boundaries |
T6062 | 429-434 | PR_EXT:000009158 | denotes | Itpr1 |
T6063 | 447-451 | NCBITaxon:10088 | denotes | mice |
T6064 | 493-501 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T6065 | 509-514 | PR_EXT:000009158 | denotes | Itpr1 |
T6066 | 524-532 | SO:0001817 | denotes | in-frame |
T6067 | 533-541 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
T6068 | 548-550 | SO_EXT:0000028 | denotes | bp |
T6069 | 558-562 | SO_EXT:0000147 | denotes | exon |
T6070 | 567-572 | PR_EXT:000009158 | denotes | Itpr1 |
T6071 | 619-627 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T6072 | 652-656 | NCBITaxon:10088 | denotes | mice |
T6073 | 681-686 | PR_EXT:000009158 | denotes | Itpr1 |
T6074 | 686-688 | SO_EXT:wild_type_entity_or_quality | denotes | wt |
T6075 | 699-703 | NCBITaxon:10088 | denotes | mice |
T6076 | 729-737 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T6077 | 739-744 | PR_EXT:000009158 | denotes | Itpr1 |
T6078 | 744-746 | SO_EXT:wild_type_entity_or_quality | denotes | wt |
T6079 | 785-789 | NCBITaxon:10088 | denotes | mice |
T6080 | 820-825 | PR_EXT:000009158 | denotes | Itpr1 |
T6081 | 833-837 | NCBITaxon_UBERON_EXT:pup | denotes | pups |
T6082 | 911-916 | PR_EXT:000009158 | denotes | Itpr1 |
T6083 | 928-933 | PR_EXT:000009158 | denotes | Itpr1 |
T6084 | 942-946 | NCBITaxon:10088 | denotes | mice |
T6085 | 1038-1043 | NCBITaxon:10088 | denotes | mouse |
T6086 | 1063-1071 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
T6087 | 1075-1080 | PR_EXT:000009158 | denotes | Itpr1 |
T6088 | 1149-1154 | PR_EXT:000009158 | denotes | Itpr1 |
T6089 | 1163-1167 | NCBITaxon:10088 | denotes | mice |
T6090 | 1179-1187 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
T6091 | 1191-1196 | SO_EXT:0000147 | denotes | exons |
T6092 | 1238-1251 | GO:0006412 | denotes | translational |
T6093 | 1252-1265 | SO_EXT:0000717 | denotes | reading frame |
T6094 | 1282-1290 | SO:0001817 | denotes | in-frame |
T6095 | 1291-1296 | PR_EXT:000009158 | denotes | Itpr1 |
T6096 | 1304-1312 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
T6097 | 1313-1321 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T6098 | 1362-1367 | PR_EXT:000009158 | denotes | Itpr1 |
T6099 | 1371-1381 | UBERON:0002037 | denotes | cerebellar |
T6100 | 1371-1396 | CL:0000121 | denotes | cerebellar Purkinje cells |
T6101 | 1391-1396 | CL_GO_EXT:cell | denotes | cells |
T6102 | 1423-1430 | SO_EXT:sequence_altered_entity | denotes | mutants |
T6103 | 1446-1451 | PR_EXT:000009158 | denotes | Itpr1 |
T6104 | 1462-1467 | NCBITaxon:10088 | denotes | mouse |
T6105 | 1485-1489 | SO_EXT:0000704 | denotes | gene |
T6106 | 1511-1516 | PR_EXT:000009158 | denotes | Itpr1 |
T6107 | 1517-1527 | GO:0010467 | denotes | expression |
T6108 | 1556-1565 | GO:0030849 | denotes | autosomal |
T6109 | 1576-1584 | GO_EXT:biological_movement_or_translocation_process | denotes | movement |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5823 | 97-102 | NCBITaxon:10088 | denotes | mouse |
T5824 | 189-196 | SO:0000704 | denotes | genetic |
T5825 | 246-254 | SO:0001817 | denotes | in-frame |
T5826 | 267-272 | SO:0000147 | denotes | exons |
T5827 | 290-294 | SO:0000704 | denotes | gene |
T5828 | 295-300 | PR:000009158 | denotes | Itpr1 |
T5829 | 302-307 | PR:000009158 | denotes | Itpr1 |
T5830 | 327-365 | PR:000009158 | denotes | inositol 1,4,5-triphosphate receptor 1 |
T5831 | 367-372 | PR:000009158 | denotes | Itpr1 |
T5832 | 393-398 | SO:0000147 | denotes | exons |
T5833 | 403-425 | SO:0001421 | denotes | intron–exon boundaries |
T5834 | 429-434 | PR:000009158 | denotes | Itpr1 |
T5835 | 447-451 | NCBITaxon:10088 | denotes | mice |
T5836 | 509-514 | PR:000009158 | denotes | Itpr1 |
T5837 | 524-532 | SO:0001817 | denotes | in-frame |
T5838 | 548-550 | SO:0000028 | denotes | bp |
T5839 | 558-562 | SO:0000147 | denotes | exon |
T5840 | 567-572 | PR:000009158 | denotes | Itpr1 |
T5841 | 652-656 | NCBITaxon:10088 | denotes | mice |
T5842 | 681-686 | PR:000009158 | denotes | Itpr1 |
T5843 | 699-703 | NCBITaxon:10088 | denotes | mice |
T5844 | 739-744 | PR:000009158 | denotes | Itpr1 |
T5845 | 785-789 | NCBITaxon:10088 | denotes | mice |
T5846 | 820-825 | PR:000009158 | denotes | Itpr1 |
T5847 | 911-916 | PR:000009158 | denotes | Itpr1 |
T5848 | 928-933 | PR:000009158 | denotes | Itpr1 |
T5849 | 942-946 | NCBITaxon:10088 | denotes | mice |
T5850 | 1038-1043 | NCBITaxon:10088 | denotes | mouse |
T5851 | 1075-1080 | PR:000009158 | denotes | Itpr1 |
T5852 | 1149-1154 | PR:000009158 | denotes | Itpr1 |
T5853 | 1163-1167 | NCBITaxon:10088 | denotes | mice |
T5854 | 1191-1196 | SO:0000147 | denotes | exons |
T5855 | 1238-1251 | GO:0006412 | denotes | translational |
T5856 | 1252-1265 | SO:0000717 | denotes | reading frame |
T5857 | 1282-1290 | SO:0001817 | denotes | in-frame |
T5858 | 1291-1296 | PR:000009158 | denotes | Itpr1 |
T5859 | 1362-1367 | PR:000009158 | denotes | Itpr1 |
T5860 | 1371-1381 | UBERON:0002037 | denotes | cerebellar |
T5861 | 1371-1396 | CL:0000121 | denotes | cerebellar Purkinje cells |
T5862 | 1446-1451 | PR:000009158 | denotes | Itpr1 |
T5863 | 1462-1467 | NCBITaxon:10088 | denotes | mouse |
T5864 | 1485-1489 | SO:0000704 | denotes | gene |
T5865 | 1511-1516 | PR:000009158 | denotes | Itpr1 |
T5866 | 1517-1527 | GO:0010467 | denotes | expression |
T5867 | 1556-1565 | GO:0030849 | denotes | autosomal |
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T6599 | 0-10 | NN | denotes | Literature |
T6600 | 11-19 | NNS | denotes | searches |
T6601 | 20-28 | VBD | denotes | revealed |
T6602 | 29-33 | IN | denotes | that |
T6603 | 103-111 | VBZ | denotes | displays |
T6604 | 34-39 | IN | denotes | among |
T6605 | 40-47 | NN | denotes | disease |
T6606 | 48-53 | NNS | denotes | lines |
T6607 | 54-60 | VBN | denotes | mapped |
T6608 | 61-63 | IN | denotes | to |
T6609 | 64-68 | NN | denotes | 6qE1 |
T6610 | 68-70 | , | denotes | , |
T6611 | 70-73 | DT | denotes | the |
T6612 | 86-92 | NN | denotes | mutant |
T6613 | 74-85 | JJ | denotes | spontaneous |
T6614 | 93-96 | NN | denotes | opt |
T6615 | 97-102 | NN | denotes | mouse |
T6616 | 112-113 | DT | denotes | a |
T6617 | 133-145 | NN | denotes | presentation |
T6618 | 114-124 | RB | denotes | strikingly |
T6619 | 125-132 | JJ | denotes | similar |
T6620 | 146-148 | IN | denotes | to |
T6621 | 149-153 | DT | denotes | that |
T6622 | 154-163 | VBN | denotes | described |
T6623 | 164-168 | RB | denotes | here |
T6624 | 169-170 | -LRB- | denotes | [ |
T6625 | 170-171 | CD | denotes | 1 |
T6626 | 171-172 | -RRB- | denotes | ] |
T6627 | 172-173 | . | denotes | . |
T6628 | 173-374 | sentence | denotes | The underlying genetic lesion causing the opt phenotype is a homozygous in-frame deletion of exons 43 and 44 of the gene Itpr1 (Itpr1opt /opt), encoding inositol 1,4,5-triphosphate receptor 1 (Itpr1). |
T6629 | 174-177 | DT | denotes | The |
T6630 | 197-203 | NN | denotes | lesion |
T6631 | 178-188 | VBG | denotes | underlying |
T6632 | 189-196 | JJ | denotes | genetic |
T6633 | 230-232 | VBZ | denotes | is |
T6634 | 204-211 | VBG | denotes | causing |
T6635 | 212-215 | DT | denotes | the |
T6636 | 220-229 | NN | denotes | phenotype |
T6637 | 216-219 | NN | denotes | opt |
T6638 | 233-234 | DT | denotes | a |
T6639 | 255-263 | NN | denotes | deletion |
T6640 | 235-245 | JJ | denotes | homozygous |
T6641 | 246-248 | IN | denotes | in |
T6642 | 249-254 | NN | denotes | frame |
T6643 | 248-249 | HYPH | denotes | - |
T6644 | 264-266 | IN | denotes | of |
T6645 | 267-272 | NNS | denotes | exons |
T6646 | 273-275 | CD | denotes | 43 |
T6647 | 276-279 | CC | denotes | and |
T6648 | 280-282 | CD | denotes | 44 |
T6649 | 283-285 | IN | denotes | of |
T6650 | 286-289 | DT | denotes | the |
T6651 | 295-300 | NN | denotes | Itpr1 |
T6652 | 290-294 | NN | denotes | gene |
T6653 | 301-302 | -LRB- | denotes | ( |
T6654 | 312-315 | NN | denotes | opt |
T6655 | 302-310 | NN | denotes | Itpr1opt |
T6656 | 311-312 | HYPH | denotes | / |
T6657 | 315-316 | -RRB- | denotes | ) |
T6658 | 316-318 | , | denotes | , |
T6659 | 318-326 | VBG | denotes | encoding |
T6660 | 327-335 | NN | denotes | inositol |
T6661 | 355-363 | NN | denotes | receptor |
T6662 | 336-337 | CD | denotes | 1 |
T6663 | 340-341 | CD | denotes | 5 |
T6664 | 337-338 | , | denotes | , |
T6665 | 338-339 | CD | denotes | 4 |
T6666 | 339-340 | , | denotes | , |
T6667 | 342-354 | NN | denotes | triphosphate |
T6668 | 341-342 | HYPH | denotes | - |
T6669 | 364-365 | CD | denotes | 1 |
T6670 | 366-367 | -LRB- | denotes | ( |
T6671 | 367-372 | NN | denotes | Itpr1 |
T6672 | 372-373 | -RRB- | denotes | ) |
T6673 | 373-374 | . | denotes | . |
T6674 | 374-581 | sentence | denotes | Sequencing of all exons and intron–exon boundaries of Itpr1 in affected mice from the current study revealed a single mutation within Itpr1: a novel in-frame deletion of 18 bp within exon 36 (Itpr1Δ18/Δ18). |
T6675 | 375-385 | NN | denotes | Sequencing |
T6676 | 475-483 | VBD | denotes | revealed |
T6677 | 386-388 | IN | denotes | of |
T6678 | 389-392 | DT | denotes | all |
T6679 | 393-398 | NNS | denotes | exons |
T6680 | 399-402 | CC | denotes | and |
T6681 | 403-409 | NN | denotes | intron |
T6682 | 410-414 | NN | denotes | exon |
T6683 | 409-410 | HYPH | denotes | – |
T6684 | 415-425 | NNS | denotes | boundaries |
T6685 | 426-428 | IN | denotes | of |
T6686 | 429-434 | NN | denotes | Itpr1 |
T6687 | 435-437 | IN | denotes | in |
T6688 | 438-446 | VBN | denotes | affected |
T6689 | 447-451 | NNS | denotes | mice |
T6690 | 452-456 | IN | denotes | from |
T6691 | 457-460 | DT | denotes | the |
T6692 | 469-474 | NN | denotes | study |
T6693 | 461-468 | JJ | denotes | current |
T6694 | 484-485 | DT | denotes | a |
T6695 | 493-501 | NN | denotes | mutation |
T6696 | 486-492 | JJ | denotes | single |
T6697 | 502-508 | IN | denotes | within |
T6698 | 509-514 | NN | denotes | Itpr1 |
T6699 | 514-516 | : | denotes | : |
T6700 | 516-517 | DT | denotes | a |
T6701 | 533-541 | NN | denotes | deletion |
T6702 | 518-523 | JJ | denotes | novel |
T6703 | 524-526 | IN | denotes | in |
T6704 | 526-527 | HYPH | denotes | - |
T6705 | 527-532 | NN | denotes | frame |
T6706 | 542-544 | IN | denotes | of |
T6707 | 545-547 | CD | denotes | 18 |
T6708 | 548-550 | NN | denotes | bp |
T6709 | 551-557 | IN | denotes | within |
T6710 | 558-562 | NN | denotes | exon |
T6711 | 563-565 | CD | denotes | 36 |
T6712 | 566-567 | -LRB- | denotes | ( |
T6713 | 576-579 | NN | denotes | Δ18 |
T6714 | 567-575 | NN | denotes | Itpr1Δ18 |
T6715 | 575-576 | HYPH | denotes | / |
T6716 | 579-580 | -RRB- | denotes | ) |
T6717 | 580-581 | . | denotes | . |
T6718 | 581-752 | sentence | denotes | To confirm the pathogenicity of this mutation we crossed heterozygous mice from the current study (Itpr1wt/Δ18) with mice heterozygous for the opt mutation (Itpr1wt/opt). |
T6719 | 582-584 | TO | denotes | To |
T6720 | 585-592 | VB | denotes | confirm |
T6721 | 631-638 | VBD | denotes | crossed |
T6722 | 593-596 | DT | denotes | the |
T6723 | 597-610 | NN | denotes | pathogenicity |
T6724 | 611-613 | IN | denotes | of |
T6725 | 614-618 | DT | denotes | this |
T6726 | 619-627 | NN | denotes | mutation |
T6727 | 628-630 | PRP | denotes | we |
T6728 | 639-651 | JJ | denotes | heterozygous |
T6729 | 652-656 | NNS | denotes | mice |
T6730 | 657-661 | IN | denotes | from |
T6731 | 662-665 | DT | denotes | the |
T6732 | 674-679 | NN | denotes | study |
T6733 | 666-673 | JJ | denotes | current |
T6734 | 680-681 | -LRB- | denotes | ( |
T6735 | 689-692 | NN | denotes | Δ18 |
T6736 | 681-688 | NN | denotes | Itpr1wt |
T6737 | 688-689 | HYPH | denotes | / |
T6738 | 692-693 | -RRB- | denotes | ) |
T6739 | 694-698 | IN | denotes | with |
T6740 | 699-703 | NNS | denotes | mice |
T6741 | 704-716 | JJ | denotes | heterozygous |
T6742 | 717-720 | IN | denotes | for |
T6743 | 721-724 | DT | denotes | the |
T6744 | 729-737 | NN | denotes | mutation |
T6745 | 725-728 | NN | denotes | opt |
T6746 | 738-739 | -LRB- | denotes | ( |
T6747 | 747-750 | NN | denotes | opt |
T6748 | 739-746 | NN | denotes | Itpr1wt |
T6749 | 746-747 | HYPH | denotes | / |
T6750 | 750-751 | -RRB- | denotes | ) |
T6751 | 751-752 | . | denotes | . |
T6752 | 752-951 | sentence | denotes | This resulted in two litters of mice with a total of four affected Itpr1opt/Δ18 pups (from a total of 15) with a phenotype indistinguishable from that of the Itpr1Δ18/Δ18 and Itpr1opt /opt mice [1]. |
T6753 | 753-757 | DT | denotes | This |
T6754 | 758-766 | VBD | denotes | resulted |
T6755 | 767-769 | IN | denotes | in |
T6756 | 770-773 | CD | denotes | two |
T6757 | 774-781 | NNS | denotes | litters |
T6758 | 782-784 | IN | denotes | of |
T6759 | 785-789 | NNS | denotes | mice |
T6760 | 790-794 | IN | denotes | with |
T6761 | 795-796 | DT | denotes | a |
T6762 | 797-802 | NN | denotes | total |
T6763 | 803-805 | IN | denotes | of |
T6764 | 806-810 | CD | denotes | four |
T6765 | 833-837 | NNS | denotes | pups |
T6766 | 811-819 | VBN | denotes | affected |
T6767 | 820-828 | NN | denotes | Itpr1opt |
T6768 | 829-832 | NN | denotes | Δ18 |
T6769 | 828-829 | HYPH | denotes | / |
T6770 | 838-839 | -LRB- | denotes | ( |
T6771 | 839-843 | IN | denotes | from |
T6772 | 844-845 | DT | denotes | a |
T6773 | 846-851 | NN | denotes | total |
T6774 | 852-854 | IN | denotes | of |
T6775 | 855-857 | CD | denotes | 15 |
T6776 | 857-858 | -RRB- | denotes | ) |
T6777 | 859-863 | IN | denotes | with |
T6778 | 864-865 | DT | denotes | a |
T6779 | 866-875 | NN | denotes | phenotype |
T6780 | 876-893 | JJ | denotes | indistinguishable |
T6781 | 894-898 | IN | denotes | from |
T6782 | 899-903 | DT | denotes | that |
T6783 | 904-906 | IN | denotes | of |
T6784 | 907-910 | DT | denotes | the |
T6785 | 942-946 | NNS | denotes | mice |
T6786 | 911-919 | NN | denotes | Itpr1Δ18 |
T6787 | 920-923 | NN | denotes | Δ18 |
T6788 | 919-920 | HYPH | denotes | / |
T6789 | 924-927 | CC | denotes | and |
T6790 | 928-936 | NN | denotes | Itpr1opt |
T6791 | 938-941 | NN | denotes | opt |
T6792 | 937-938 | HYPH | denotes | / |
T6793 | 947-948 | -LRB- | denotes | [ |
T6794 | 948-949 | CD | denotes | 1 |
T6795 | 949-950 | -RRB- | denotes | ] |
T6796 | 950-951 | . | denotes | . |
T6797 | 951-1136 | sentence | denotes | Furthermore, this phenotype was similar, although less severe, to that described in a mouse line with targeted deletion of Itpr1, where ataxia was described as a prominent feature [4]. |
T6798 | 952-963 | RB | denotes | Furthermore |
T6799 | 980-983 | VBD | denotes | was |
T6800 | 963-965 | , | denotes | , |
T6801 | 965-969 | DT | denotes | this |
T6802 | 970-979 | NN | denotes | phenotype |
T6803 | 984-991 | JJ | denotes | similar |
T6804 | 991-993 | , | denotes | , |
T6805 | 993-1001 | IN | denotes | although |
T6806 | 1007-1013 | JJ | denotes | severe |
T6807 | 1002-1006 | RBR | denotes | less |
T6808 | 1013-1015 | , | denotes | , |
T6809 | 1015-1017 | IN | denotes | to |
T6810 | 1018-1022 | DT | denotes | that |
T6811 | 1023-1032 | VBN | denotes | described |
T6812 | 1033-1035 | IN | denotes | in |
T6813 | 1036-1037 | DT | denotes | a |
T6814 | 1044-1048 | NN | denotes | line |
T6815 | 1038-1043 | NN | denotes | mouse |
T6816 | 1049-1053 | IN | denotes | with |
T6817 | 1054-1062 | VBN | denotes | targeted |
T6818 | 1063-1071 | NN | denotes | deletion |
T6819 | 1072-1074 | IN | denotes | of |
T6820 | 1075-1080 | NN | denotes | Itpr1 |
T6821 | 1080-1082 | , | denotes | , |
T6822 | 1082-1087 | WRB | denotes | where |
T6823 | 1099-1108 | VBN | denotes | described |
T6824 | 1088-1094 | NN | denotes | ataxia |
T6825 | 1095-1098 | VBD | denotes | was |
T6826 | 1109-1111 | IN | denotes | as |
T6827 | 1112-1113 | DT | denotes | a |
T6828 | 1124-1131 | NN | denotes | feature |
T6829 | 1114-1123 | JJ | denotes | prominent |
T6830 | 1132-1133 | -LRB- | denotes | [ |
T6831 | 1133-1134 | CD | denotes | 4 |
T6832 | 1134-1135 | -RRB- | denotes | ] |
T6833 | 1135-1136 | . | denotes | . |
T6834 | 1136-1397 | sentence | denotes | As with the Itpr1opt /opt mice, where the deletion of exons 43 and 44 is also predicted to leave the translational reading frame unaffected, the in-frame Itpr1Δ18/Δ18 deletion mutation results in markedly decreased levels of Itpr1 in cerebellar Purkinje cells. |
T6835 | 1137-1139 | IN | denotes | As |
T6836 | 1322-1329 | VBZ | denotes | results |
T6837 | 1140-1144 | IN | denotes | with |
T6838 | 1145-1148 | DT | denotes | the |
T6839 | 1163-1167 | NNS | denotes | mice |
T6840 | 1149-1157 | NN | denotes | Itpr1opt |
T6841 | 1159-1162 | NN | denotes | opt |
T6842 | 1158-1159 | HYPH | denotes | / |
T6843 | 1167-1169 | , | denotes | , |
T6844 | 1169-1174 | WRB | denotes | where |
T6845 | 1215-1224 | VBN | denotes | predicted |
T6846 | 1175-1178 | DT | denotes | the |
T6847 | 1179-1187 | NN | denotes | deletion |
T6848 | 1188-1190 | IN | denotes | of |
T6849 | 1191-1196 | NNS | denotes | exons |
T6850 | 1197-1199 | CD | denotes | 43 |
T6851 | 1200-1203 | CC | denotes | and |
T6852 | 1204-1206 | CD | denotes | 44 |
T6853 | 1207-1209 | VBZ | denotes | is |
T6854 | 1210-1214 | RB | denotes | also |
T6855 | 1225-1227 | TO | denotes | to |
T6856 | 1228-1233 | VB | denotes | leave |
T6857 | 1234-1237 | DT | denotes | the |
T6858 | 1260-1265 | NN | denotes | frame |
T6859 | 1238-1251 | JJ | denotes | translational |
T6860 | 1252-1259 | NN | denotes | reading |
T6861 | 1266-1276 | JJ | denotes | unaffected |
T6862 | 1276-1278 | , | denotes | , |
T6863 | 1278-1281 | DT | denotes | the |
T6864 | 1313-1321 | NN | denotes | mutation |
T6865 | 1282-1284 | IN | denotes | in |
T6866 | 1284-1285 | HYPH | denotes | - |
T6867 | 1285-1290 | NN | denotes | frame |
T6868 | 1291-1299 | NN | denotes | Itpr1Δ18 |
T6869 | 1300-1303 | NN | denotes | Δ18 |
T6870 | 1299-1300 | HYPH | denotes | / |
T6871 | 1304-1312 | NN | denotes | deletion |
T6872 | 1330-1332 | IN | denotes | in |
T6873 | 1333-1341 | RB | denotes | markedly |
T6874 | 1342-1351 | VBN | denotes | decreased |
T6875 | 1352-1358 | NNS | denotes | levels |
T6876 | 1359-1361 | IN | denotes | of |
T6877 | 1362-1367 | NN | denotes | Itpr1 |
T6878 | 1368-1370 | IN | denotes | in |
T6879 | 1371-1381 | JJ | denotes | cerebellar |
T6880 | 1391-1396 | NNS | denotes | cells |
T6881 | 1382-1390 | NNP | denotes | Purkinje |
T6882 | 1396-1397 | . | denotes | . |
T6883 | 1397-1605 | sentence | denotes | In these two spontaneous mutants [1] and in the Itpr1-deficient mouse [4] generated by gene targeting, decreased Itpr1 expression is associated with the same autosomal recessive movement disorder (Figure 1). |
T6884 | 1398-1400 | IN | denotes | In |
T6885 | 1531-1541 | VBN | denotes | associated |
T6886 | 1401-1406 | DT | denotes | these |
T6887 | 1423-1430 | NNS | denotes | mutants |
T6888 | 1407-1410 | CD | denotes | two |
T6889 | 1411-1422 | JJ | denotes | spontaneous |
T6890 | 1431-1432 | -LRB- | denotes | [ |
T6891 | 1432-1433 | CD | denotes | 1 |
T6892 | 1433-1434 | -RRB- | denotes | ] |
T6893 | 1435-1438 | CC | denotes | and |
T6894 | 1439-1441 | IN | denotes | in |
T6895 | 1442-1445 | DT | denotes | the |
T6896 | 1462-1467 | NN | denotes | mouse |
T6897 | 1446-1451 | NN | denotes | Itpr1 |
T6898 | 1452-1461 | JJ | denotes | deficient |
T6899 | 1451-1452 | HYPH | denotes | - |
T6900 | 1468-1469 | -LRB- | denotes | [ |
T6901 | 1469-1470 | CD | denotes | 4 |
T6902 | 1470-1471 | -RRB- | denotes | ] |
T6903 | 1472-1481 | VBN | denotes | generated |
T6904 | 1482-1484 | IN | denotes | by |
T6905 | 1485-1489 | NN | denotes | gene |
T6906 | 1490-1499 | NN | denotes | targeting |
T6907 | 1499-1501 | , | denotes | , |
T6908 | 1501-1510 | VBN | denotes | decreased |
T6909 | 1517-1527 | NN | denotes | expression |
T6910 | 1511-1516 | NN | denotes | Itpr1 |
T6911 | 1528-1530 | VBZ | denotes | is |
T6912 | 1542-1546 | IN | denotes | with |
T6913 | 1547-1550 | DT | denotes | the |
T6914 | 1585-1593 | NN | denotes | disorder |
T6915 | 1551-1555 | JJ | denotes | same |
T6916 | 1556-1565 | JJ | denotes | autosomal |
T6917 | 1566-1575 | JJ | denotes | recessive |
T6918 | 1576-1584 | NN | denotes | movement |
T6919 | 1594-1595 | -LRB- | denotes | ( |
T6920 | 1595-1601 | NN | denotes | Figure |
T6921 | 1602-1603 | CD | denotes | 1 |
T6922 | 1603-1604 | -RRB- | denotes | ) |
T6923 | 1604-1605 | . | denotes | . |
R576 | T6599 | T6600 | compound | Literature,searches |
R577 | T6600 | T6601 | nsubj | searches,revealed |
R579 | T6602 | T6603 | mark | that,displays |
R581 | T6603 | T6601 | ccomp | displays,revealed |
R582 | T6604 | T6603 | prep | among,displays |
R583 | T6605 | T6606 | compound | disease,lines |
R585 | T6606 | T6604 | pobj | lines,among |
R586 | T6607 | T6606 | acl | mapped,lines |
R587 | T6608 | T6607 | prep | to,mapped |
R589 | T6609 | T6608 | pobj | 6qE1,to |
R590 | T6610 | T6603 | punct | ", ",displays |
R592 | T6611 | T6612 | det | the,mutant |
R593 | T6612 | T6603 | nsubj | mutant,displays |
R594 | T6613 | T6612 | amod | spontaneous,mutant |
R596 | T6614 | T6615 | compound | opt,mouse |
R597 | T6615 | T6612 | appos | mouse,mutant |
R598 | T6616 | T6617 | det | a,presentation |
R599 | T6617 | T6603 | dobj | presentation,displays |
R601 | T6618 | T6619 | advmod | strikingly,similar |
R602 | T6619 | T6617 | amod | similar,presentation |
R604 | T6620 | T6617 | prep | to,presentation |
R605 | T6621 | T6620 | pobj | that,to |
R606 | T6622 | T6621 | acl | described,that |
R607 | T6623 | T6622 | advmod | here,described |
R609 | T6624 | T6625 | punct | [,1 |
R610 | T6625 | T6601 | parataxis | 1,revealed |
R611 | T6626 | T6625 | punct | ],1 |
R612 | T6627 | T6601 | punct | .,revealed |
R615 | T6629 | T6630 | det | The,lesion |
R616 | T6630 | T6633 | nsubj | lesion,is |
R617 | T6631 | T6630 | amod | underlying,lesion |
R618 | T6632 | T6630 | amod | genetic,lesion |
R620 | T6634 | T6630 | acl | causing,lesion |
R622 | T6635 | T6636 | det | the,phenotype |
R623 | T6636 | T6634 | dobj | phenotype,causing |
R624 | T6637 | T6636 | compound | opt,phenotype |
R626 | T6638 | T6639 | det | a,deletion |
R627 | T6639 | T6633 | attr | deletion,is |
R628 | T6640 | T6639 | amod | homozygous,deletion |
R629 | T6641 | T6642 | nmod | in,frame |
R631 | T6642 | T6639 | compound | frame,deletion |
R632 | T6643 | T6642 | punct | -,frame |
R634 | T6644 | T6639 | prep | of,deletion |
R635 | T6645 | T6646 | nmod | exons,43 |
R636 | T6646 | T6644 | pobj | 43,of |
R638 | T6647 | T6646 | cc | and,43 |
R639 | T6648 | T6646 | conj | 44,43 |
R640 | T6649 | T6646 | prep | of,43 |
R642 | T6650 | T6651 | det | the,Itpr1 |
R643 | T6651 | T6649 | pobj | Itpr1,of |
R644 | T6652 | T6651 | compound | gene,Itpr1 |
R646 | T6653 | T6654 | punct | (,opt |
R647 | T6654 | T6651 | parataxis | opt,Itpr1 |
R648 | T6655 | T6654 | compound | Itpr1opt,opt |
R650 | T6656 | T6654 | punct | /,opt |
R651 | T6657 | T6654 | punct | ),opt |
R652 | T6658 | T6646 | punct | ", ",43 |
R653 | T6659 | T6646 | acl | encoding,43 |
R655 | T6660 | T6661 | nmod | inositol,receptor |
R656 | T6661 | T6659 | dobj | receptor,encoding |
R657 | T6662 | T6663 | nummod | 1,5 |
R658 | T6663 | T6667 | nummod | 5,triphosphate |
R659 | T6664 | T6663 | punct | ",",5 |
R660 | T6665 | T6663 | nummod | 4,5 |
R661 | T6666 | T6663 | punct | ",",5 |
R662 | T6667 | T6661 | compound | triphosphate,receptor |
R663 | T6668 | T6667 | punct | -,triphosphate |
R665 | T6669 | T6661 | nummod | 1,receptor |
R666 | T6670 | T6671 | punct | (,Itpr1 |
R667 | T6671 | T6661 | parataxis | Itpr1,receptor |
R669 | T6672 | T6671 | punct | ),Itpr1 |
R670 | T6673 | T6633 | punct | .,is |
R672 | T6675 | T6676 | nsubj | Sequencing,revealed |
R674 | T6677 | T6675 | prep | of,Sequencing |
R676 | T6678 | T6679 | det | all,exons |
R677 | T6679 | T6677 | pobj | exons,of |
R679 | T6680 | T6679 | cc | and,exons |
R680 | T6681 | T6682 | compound | intron,exon |
R681 | T6682 | T6684 | compound | exon,boundaries |
R683 | T6683 | T6682 | punct | –,exon |
R686 | T6684 | T6679 | conj | boundaries,exons |
R688 | T6685 | T6684 | prep | of,boundaries |
R689 | T6686 | T6685 | pobj | Itpr1,of |
R691 | T6687 | T6679 | prep | in,exons |
R692 | T6688 | T6689 | amod | affected,mice |
R694 | T6689 | T6687 | pobj | mice,in |
R695 | T6690 | T6689 | prep | from,mice |
R697 | T6691 | T6692 | det | the,study |
R698 | T6692 | T6690 | pobj | study,from |
R699 | T6693 | T6692 | amod | current,study |
R701 | T6694 | T6695 | det | a,mutation |
R702 | T6695 | T6676 | dobj | mutation,revealed |
R703 | T6696 | T6695 | amod | single,mutation |
R705 | T6697 | T6695 | prep | within,mutation |
R706 | T6698 | T6697 | pobj | Itpr1,within |
R707 | T6699 | T6695 | punct | : ,mutation |
R709 | T6700 | T6701 | det | a,deletion |
R710 | T6701 | T6695 | appos | deletion,mutation |
R711 | T6702 | T6701 | amod | novel,deletion |
R712 | T6703 | T6701 | nmod | in,deletion |
R713 | T6704 | T6703 | punct | -,in |
R714 | T6705 | T6703 | pobj | frame,in |
R716 | T6706 | T6701 | prep | of,deletion |
R717 | T6707 | T6708 | nummod | 18,bp |
R718 | T6708 | T6706 | pobj | bp,of |
R720 | T6709 | T6701 | prep | within,deletion |
R722 | T6710 | T6709 | pobj | exon,within |
R723 | T6711 | T6710 | nummod | 36,exon |
R724 | T6712 | T6713 | punct | (,Δ18 |
R725 | T6713 | T6701 | parataxis | Δ18,deletion |
R727 | T6714 | T6713 | compound | Itpr1Δ18,Δ18 |
R728 | T6715 | T6713 | punct | /,Δ18 |
R729 | T6716 | T6713 | punct | ),Δ18 |
R731 | T6717 | T6676 | punct | .,revealed |
R732 | T6719 | T6720 | aux | To,confirm |
R734 | T6720 | T6721 | advcl | confirm,crossed |
R735 | T6722 | T6723 | det | the,pathogenicity |
R737 | T6723 | T6720 | dobj | pathogenicity,confirm |
R738 | T6724 | T6723 | prep | of,pathogenicity |
R739 | T6725 | T6726 | det | this,mutation |
R741 | T6726 | T6724 | pobj | mutation,of |
R742 | T6727 | T6721 | nsubj | we,crossed |
R744 | T6728 | T6729 | amod | heterozygous,mice |
R745 | T6729 | T6721 | dobj | mice,crossed |
R746 | T6730 | T6729 | prep | from,mice |
R747 | T6731 | T6732 | det | the,study |
R749 | T6732 | T6730 | pobj | study,from |
R750 | T6733 | T6732 | amod | current,study |
R752 | T6734 | T6735 | punct | (,Δ18 |
R753 | T6735 | T6730 | parataxis | Δ18,from |
R754 | T6736 | T6735 | compound | Itpr1wt,Δ18 |
R755 | T6737 | T6735 | punct | /,Δ18 |
R757 | T6738 | T6735 | punct | ),Δ18 |
R758 | T6739 | T6721 | prep | with,crossed |
R759 | T6789 | T6787 | cc | and,Δ18 |
R760 | T6740 | T6739 | pobj | mice,with |
R761 | T6741 | T6740 | amod | heterozygous,mice |
R762 | T6742 | T6741 | prep | for,heterozygous |
R763 | T6743 | T6744 | det | the,mutation |
R764 | T6744 | T6742 | pobj | mutation,for |
R765 | T6745 | T6744 | compound | opt,mutation |
R766 | T6746 | T6747 | punct | (,opt |
R767 | T6747 | T6740 | parataxis | opt,mice |
R768 | T6748 | T6747 | compound | Itpr1wt,opt |
R769 | T6749 | T6747 | punct | /,opt |
R770 | T6790 | T6791 | compound | Itpr1opt,opt |
R771 | T6750 | T6747 | punct | ),opt |
R772 | T6751 | T6721 | punct | .,crossed |
R773 | T6791 | T6787 | conj | opt,Δ18 |
R774 | T6753 | T6754 | nsubj | This,resulted |
R775 | T6755 | T6754 | prep | in,resulted |
R776 | T6792 | T6791 | punct | /,opt |
R777 | T6756 | T6757 | nummod | two,litters |
R778 | T6757 | T6755 | pobj | litters,in |
R779 | T6758 | T6757 | prep | of,litters |
R780 | T6793 | T6794 | punct | [,1 |
R781 | T6759 | T6758 | pobj | mice,of |
R782 | T6760 | T6757 | prep | with,litters |
R783 | T6761 | T6762 | det | a,total |
R784 | T6794 | T6754 | parataxis | 1,resulted |
R785 | T6762 | T6760 | pobj | total,with |
R786 | T6795 | T6794 | punct | ],1 |
R787 | T6763 | T6762 | prep | of,total |
R788 | T6796 | T6754 | punct | .,resulted |
R789 | T6764 | T6765 | nummod | four,pups |
R790 | T6765 | T6763 | pobj | pups,of |
R791 | T6766 | T6765 | amod | affected,pups |
R792 | T6798 | T6799 | advmod | Furthermore,was |
R793 | T6767 | T6768 | compound | Itpr1opt,Δ18 |
R794 | T6768 | T6765 | compound | Δ18,pups |
R795 | T6769 | T6768 | punct | /,Δ18 |
R796 | T6770 | T6762 | punct | (,total |
R797 | T6800 | T6799 | punct | ", ",was |
R798 | T6771 | T6762 | prep | from,total |
R799 | T6772 | T6773 | det | a,total |
R800 | T6773 | T6771 | pobj | total,from |
R801 | T6801 | T6802 | det | this,phenotype |
R802 | T6774 | T6773 | prep | of,total |
R803 | T6775 | T6774 | pobj | 15,of |
R804 | T6776 | T6762 | punct | ),total |
R805 | T6802 | T6799 | nsubj | phenotype,was |
R806 | T6777 | T6762 | prep | with,total |
R807 | T6778 | T6779 | det | a,phenotype |
R808 | T6779 | T6777 | pobj | phenotype,with |
R809 | T6803 | T6799 | acomp | similar,was |
R810 | T6780 | T6779 | amod | indistinguishable,phenotype |
R811 | T6781 | T6780 | prep | from,indistinguishable |
R812 | T6782 | T6781 | pobj | that,from |
R813 | T6783 | T6782 | prep | of,that |
R814 | T6784 | T6785 | det | the,mice |
R815 | T6785 | T6783 | pobj | mice,of |
R816 | T6804 | T6799 | punct | ", ",was |
R817 | T6786 | T6787 | nmod | Itpr1Δ18,Δ18 |
R818 | T6787 | T6785 | nmod | Δ18,mice |
R819 | T6788 | T6787 | punct | /,Δ18 |
R820 | T6805 | T6806 | mark | although,severe |
R821 | T6806 | T6799 | advcl | severe,was |
R822 | T6807 | T6806 | advmod | less,severe |
R823 | T6895 | T6896 | det | the,mouse |
R824 | T6808 | T6799 | punct | ", ",was |
R825 | T6896 | T6894 | pobj | mouse,in |
R826 | T6897 | T6898 | npadvmod | Itpr1,deficient |
R827 | T6898 | T6896 | amod | deficient,mouse |
R828 | T6809 | T6799 | prep | to,was |
R829 | T6899 | T6898 | punct | -,deficient |
R830 | T6810 | T6809 | pobj | that,to |
R831 | T6900 | T6901 | punct | [,4 |
R832 | T6901 | T6896 | parataxis | 4,mouse |
R833 | T6902 | T6901 | punct | ],4 |
R834 | T6811 | T6810 | acl | described,that |
R835 | T6903 | T6896 | acl | generated,mouse |
R836 | T6904 | T6903 | prep | by,generated |
R837 | T6905 | T6906 | compound | gene,targeting |
R838 | T6906 | T6904 | pobj | targeting,by |
R839 | T6812 | T6811 | prep | in,described |
R840 | T6907 | T6885 | punct | ", ",associated |
R841 | T6908 | T6909 | amod | decreased,expression |
R842 | T6813 | T6814 | det | a,line |
R843 | T6909 | T6885 | nsubjpass | expression,associated |
R844 | T6910 | T6909 | compound | Itpr1,expression |
R845 | T6911 | T6885 | auxpass | is,associated |
R846 | T6814 | T6812 | pobj | line,in |
R847 | T6912 | T6885 | prep | with,associated |
R848 | T6913 | T6914 | det | the,disorder |
R849 | T6914 | T6912 | pobj | disorder,with |
R850 | T6915 | T6914 | amod | same,disorder |
R851 | T6815 | T6814 | compound | mouse,line |
R852 | T6916 | T6914 | amod | autosomal,disorder |
R853 | T6917 | T6914 | amod | recessive,disorder |
R854 | T6816 | T6814 | prep | with,line |
R855 | T6918 | T6914 | compound | movement,disorder |
R856 | T6919 | T6920 | punct | (,Figure |
R857 | T6920 | T6885 | parataxis | Figure,associated |
R858 | T6921 | T6920 | nummod | 1,Figure |
R859 | T6817 | T6818 | amod | targeted,deletion |
R860 | T6922 | T6920 | punct | ),Figure |
R861 | T6923 | T6885 | punct | .,associated |
R862 | T6818 | T6816 | pobj | deletion,with |
R868 | T6819 | T6818 | prep | of,deletion |
R871 | T6820 | T6819 | pobj | Itpr1,of |
R872 | T6821 | T6820 | punct | ", ",Itpr1 |
R875 | T6822 | T6823 | advmod | where,described |
R876 | T6823 | T6820 | relcl | described,Itpr1 |
R878 | T6824 | T6823 | nsubjpass | ataxia,described |
R881 | T6825 | T6823 | auxpass | was,described |
R884 | T6826 | T6823 | prep | as,described |
R886 | T6827 | T6828 | det | a,feature |
R890 | T6828 | T6826 | pobj | feature,as |
R893 | T6829 | T6828 | amod | prominent,feature |
R897 | T6830 | T6831 | punct | [,4 |
R901 | T6831 | T6799 | parataxis | 4,was |
R905 | T6832 | T6831 | punct | ],4 |
R908 | T6833 | T6799 | punct | .,was |
R912 | T6835 | T6836 | prep | As,results |
R916 | T6837 | T6835 | prep | with,As |
R923 | T6838 | T6839 | det | the,mice |
R927 | T6839 | T6837 | pobj | mice,with |
R931 | T6840 | T6841 | compound | Itpr1opt,opt |
R934 | T6841 | T6839 | compound | opt,mice |
R937 | T6842 | T6841 | punct | /,opt |
R940 | T6843 | T6839 | punct | ", ",mice |
R944 | T6844 | T6845 | advmod | where,predicted |
R948 | T6845 | T6839 | relcl | predicted,mice |
R952 | T6846 | T6847 | det | the,deletion |
R955 | T6847 | T6845 | nsubjpass | deletion,predicted |
R959 | T6848 | T6847 | prep | of,deletion |
R962 | T6849 | T6850 | nmod | exons,43 |
R963 | T6850 | T6848 | pobj | 43,of |
R965 | T6851 | T6850 | cc | and,43 |
R972 | T6852 | T6850 | conj | 44,43 |
R976 | T6853 | T6845 | auxpass | is,predicted |
R980 | T6854 | T6845 | advmod | also,predicted |
R984 | T6855 | T6856 | aux | to,leave |
R986 | T6856 | T6845 | xcomp | leave,predicted |
R987 | T6857 | T6858 | det | the,frame |
R990 | T6858 | T6856 | dobj | frame,leave |
R993 | T6859 | T6858 | amod | translational,frame |
R996 | T6860 | T6858 | compound | reading,frame |
R1000 | T6861 | T6856 | oprd | unaffected,leave |
R1003 | T6862 | T6836 | punct | ", ",results |
R1007 | T6863 | T6864 | det | the,mutation |
R1010 | T6864 | T6836 | nsubj | mutation,results |
R1013 | T6865 | T6864 | nmod | in,mutation |
R1016 | T6866 | T6865 | punct | -,in |
R1020 | T6867 | T6865 | pobj | frame,in |
R1027 | T6868 | T6869 | compound | Itpr1Δ18,Δ18 |
R1031 | T6869 | T6864 | compound | Δ18,mutation |
R1035 | T6870 | T6869 | punct | /,Δ18 |
R1038 | T6871 | T6864 | compound | deletion,mutation |
R1042 | T6872 | T6836 | prep | in,results |
R1046 | T6873 | T6874 | advmod | markedly,decreased |
R1050 | T6874 | T6875 | amod | decreased,levels |
R1054 | T6875 | T6872 | pobj | levels,in |
R1058 | T6876 | T6875 | prep | of,levels |
R1062 | T6877 | T6876 | pobj | Itpr1,of |
R1066 | T6878 | T6836 | prep | in,results |
R1068 | T6879 | T6880 | amod | cerebellar,cells |
R1071 | T6880 | T6878 | pobj | cells,in |
R1078 | T6881 | T6880 | compound | Purkinje,cells |
R1082 | T6882 | T6836 | punct | .,results |
R1086 | T6884 | T6885 | prep | In,associated |
R1091 | T6886 | T6887 | det | these,mutants |
R1096 | T6887 | T6884 | pobj | mutants,In |
R1097 | T6888 | T6887 | nummod | two,mutants |
R1100 | T6889 | T6887 | amod | spontaneous,mutants |
R1103 | T6890 | T6891 | punct | [,1 |
R1104 | T6891 | T6887 | parataxis | 1,mutants |
R1105 | T6892 | T6891 | punct | ],1 |
R1109 | T6893 | T6884 | cc | and,In |
R1111 | T6894 | T6884 | conj | in,In |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
17590087-8987786-85657843 | 170-171 | 8987786 | denotes | 1 |
17590087-8987786-85657844 | 948-949 | 8987786 | denotes | 1 |
17590087-8538767-85657845 | 1133-1134 | 8538767 | denotes | 4 |
17590087-8987786-85657846 | 1432-1433 | 8987786 | denotes | 1 |
17590087-8538767-85657847 | 1469-1470 | 8538767 | denotes | 4 |
T11516 | 170-171 | 8987786 | denotes | 1 |
T73331 | 948-949 | 8987786 | denotes | 1 |
T33757 | 1133-1134 | 8538767 | denotes | 4 |
T76186 | 1432-1433 | 8987786 | denotes | 1 |
T38217 | 1469-1470 | 8538767 | denotes | 4 |