Id |
Subject |
Object |
Predicate |
Lexical cue |
T9612 |
0-14 |
NN |
denotes |
Identification |
T9613 |
77-86 |
VBN |
denotes |
performed |
T9614 |
15-17 |
IN |
denotes |
of |
T9615 |
18-25 |
JJ |
denotes |
similar |
T9616 |
26-36 |
NNS |
denotes |
phenotypes |
T9617 |
37-39 |
IN |
denotes |
in |
T9618 |
40-44 |
NNS |
denotes |
mice |
T9619 |
45-51 |
VBN |
denotes |
linked |
T9620 |
52-54 |
IN |
denotes |
to |
T9621 |
55-58 |
DT |
denotes |
the |
T9622 |
64-72 |
NN |
denotes |
interval |
T9623 |
59-63 |
NN |
denotes |
6qE1 |
T9624 |
73-76 |
VBD |
denotes |
was |
T9625 |
87-89 |
IN |
denotes |
by |
T9626 |
90-100 |
NN |
denotes |
literature |
T9627 |
101-109 |
NNS |
denotes |
searches |
T9628 |
109-110 |
. |
denotes |
. |
T9629 |
110-236 |
sentence |
denotes |
This revealed the Itpr1opt/opt mouse, in which disease is caused by homozygous deletion mutation of exons 43 and 44 of Itpr1. |
T9630 |
111-115 |
DT |
denotes |
This |
T9631 |
116-124 |
VBD |
denotes |
revealed |
T9632 |
125-128 |
DT |
denotes |
the |
T9633 |
142-147 |
NN |
denotes |
mouse |
T9634 |
129-137 |
NN |
denotes |
Itpr1opt |
T9635 |
138-141 |
NN |
denotes |
opt |
T9636 |
137-138 |
HYPH |
denotes |
/ |
T9637 |
147-149 |
, |
denotes |
, |
T9638 |
149-151 |
IN |
denotes |
in |
T9639 |
169-175 |
VBN |
denotes |
caused |
T9640 |
152-157 |
WDT |
denotes |
which |
T9641 |
158-165 |
NN |
denotes |
disease |
T9642 |
166-168 |
VBZ |
denotes |
is |
T9643 |
176-178 |
IN |
denotes |
by |
T9644 |
179-189 |
JJ |
denotes |
homozygous |
T9645 |
199-207 |
NN |
denotes |
mutation |
T9646 |
190-198 |
NN |
denotes |
deletion |
T9647 |
208-210 |
IN |
denotes |
of |
T9648 |
211-216 |
NNS |
denotes |
exons |
T9649 |
217-219 |
CD |
denotes |
43 |
T9650 |
220-223 |
CC |
denotes |
and |
T9651 |
224-226 |
CD |
denotes |
44 |
T9652 |
227-229 |
IN |
denotes |
of |
T9653 |
230-235 |
NN |
denotes |
Itpr1 |
T9654 |
235-236 |
. |
denotes |
. |
T9655 |
236-364 |
sentence |
denotes |
Primer pairs were designed to sequence each of the coding exons and at least 50 bp of each flanking intronic sequence of Itpr1. |
T9656 |
237-243 |
NN |
denotes |
Primer |
T9657 |
244-249 |
NNS |
denotes |
pairs |
T9658 |
255-263 |
VBN |
denotes |
designed |
T9659 |
250-254 |
VBD |
denotes |
were |
T9660 |
264-266 |
TO |
denotes |
to |
T9661 |
267-275 |
VB |
denotes |
sequence |
T9662 |
276-280 |
DT |
denotes |
each |
T9663 |
281-283 |
IN |
denotes |
of |
T9664 |
284-287 |
DT |
denotes |
the |
T9665 |
295-300 |
NNS |
denotes |
exons |
T9666 |
288-294 |
NN |
denotes |
coding |
T9667 |
301-304 |
CC |
denotes |
and |
T9668 |
305-307 |
RB |
denotes |
at |
T9669 |
314-316 |
CD |
denotes |
50 |
T9670 |
308-313 |
RBS |
denotes |
least |
T9671 |
317-319 |
NN |
denotes |
bp |
T9672 |
320-322 |
IN |
denotes |
of |
T9673 |
323-327 |
DT |
denotes |
each |
T9674 |
346-354 |
NN |
denotes |
sequence |
T9675 |
328-336 |
VBG |
denotes |
flanking |
T9676 |
337-345 |
JJ |
denotes |
intronic |
T9677 |
355-357 |
IN |
denotes |
of |
T9678 |
358-363 |
NN |
denotes |
Itpr1 |
T9679 |
363-364 |
. |
denotes |
. |
T9680 |
364-456 |
sentence |
denotes |
PCR amplification of each exon was performed using DNA from two affected mice as templates. |
T9681 |
365-368 |
NN |
denotes |
PCR |
T9682 |
369-382 |
NN |
denotes |
amplification |
T9683 |
400-409 |
VBN |
denotes |
performed |
T9684 |
383-385 |
IN |
denotes |
of |
T9685 |
386-390 |
DT |
denotes |
each |
T9686 |
391-395 |
NN |
denotes |
exon |
T9687 |
396-399 |
VBD |
denotes |
was |
T9688 |
410-415 |
VBG |
denotes |
using |
T9689 |
416-419 |
NN |
denotes |
DNA |
T9690 |
420-424 |
IN |
denotes |
from |
T9691 |
425-428 |
CD |
denotes |
two |
T9692 |
438-442 |
NNS |
denotes |
mice |
T9693 |
429-437 |
VBN |
denotes |
affected |
T9694 |
443-445 |
IN |
denotes |
as |
T9695 |
446-455 |
NNS |
denotes |
templates |
T9696 |
455-456 |
. |
denotes |
. |
T9697 |
456-544 |
sentence |
denotes |
The Itpr1Δ18/Δ18 mutation was confirmed by sequencing in all affected mice (Figure S2). |
T9698 |
457-460 |
DT |
denotes |
The |
T9699 |
474-482 |
NN |
denotes |
mutation |
T9700 |
461-469 |
NN |
denotes |
Itpr1Δ18 |
T9701 |
470-473 |
NN |
denotes |
Δ18 |
T9702 |
469-470 |
HYPH |
denotes |
/ |
T9703 |
487-496 |
VBN |
denotes |
confirmed |
T9704 |
483-486 |
VBD |
denotes |
was |
T9705 |
497-499 |
IN |
denotes |
by |
T9706 |
500-510 |
NN |
denotes |
sequencing |
T9707 |
511-513 |
IN |
denotes |
in |
T9708 |
514-517 |
DT |
denotes |
all |
T9709 |
527-531 |
NNS |
denotes |
mice |
T9710 |
518-526 |
VBN |
denotes |
affected |
T9711 |
532-533 |
-LRB- |
denotes |
( |
T9712 |
540-542 |
NN |
denotes |
S2 |
T9713 |
533-539 |
NN |
denotes |
Figure |
T9714 |
542-543 |
-RRB- |
denotes |
) |
T9715 |
543-544 |
. |
denotes |
. |
R2717 |
T9612 |
T9613 |
nsubjpass |
Identification,performed |
R2718 |
T9614 |
T9612 |
prep |
of,Identification |
R2719 |
T9615 |
T9616 |
amod |
similar,phenotypes |
R2720 |
T9616 |
T9614 |
pobj |
phenotypes,of |
R2721 |
T9617 |
T9616 |
prep |
in,phenotypes |
R2722 |
T9618 |
T9617 |
pobj |
mice,in |
R2723 |
T9619 |
T9618 |
acl |
linked,mice |
R2724 |
T9620 |
T9619 |
prep |
to,linked |
R2725 |
T9621 |
T9622 |
det |
the,interval |
R2726 |
T9622 |
T9620 |
pobj |
interval,to |
R2727 |
T9623 |
T9622 |
compound |
6qE1,interval |
R2728 |
T9624 |
T9613 |
auxpass |
was,performed |
R2729 |
T9625 |
T9613 |
prep |
by,performed |
R2730 |
T9626 |
T9627 |
compound |
literature,searches |
R2731 |
T9627 |
T9625 |
pobj |
searches,by |
R2732 |
T9628 |
T9613 |
punct |
.,performed |
R2733 |
T9630 |
T9631 |
nsubj |
This,revealed |
R2734 |
T9632 |
T9633 |
det |
the,mouse |
R2735 |
T9633 |
T9631 |
dobj |
mouse,revealed |
R2736 |
T9634 |
T9635 |
compound |
Itpr1opt,opt |
R2737 |
T9635 |
T9633 |
compound |
opt,mouse |
R2738 |
T9636 |
T9635 |
punct |
/,opt |
R2739 |
T9637 |
T9633 |
punct |
", ",mouse |
R2740 |
T9638 |
T9639 |
prep |
in,caused |
R2741 |
T9639 |
T9633 |
relcl |
caused,mouse |
R2742 |
T9640 |
T9638 |
pobj |
which,in |
R2743 |
T9641 |
T9639 |
nsubjpass |
disease,caused |
R2744 |
T9642 |
T9639 |
auxpass |
is,caused |
R2745 |
T9643 |
T9639 |
agent |
by,caused |
R2746 |
T9644 |
T9645 |
amod |
homozygous,mutation |
R2747 |
T9645 |
T9643 |
pobj |
mutation,by |
R2748 |
T9646 |
T9645 |
compound |
deletion,mutation |
R2749 |
T9647 |
T9645 |
prep |
of,mutation |
R2750 |
T9648 |
T9649 |
nmod |
exons,43 |
R2751 |
T9649 |
T9647 |
pobj |
43,of |
R2752 |
T9650 |
T9649 |
cc |
and,43 |
R2753 |
T9651 |
T9649 |
conj |
44,43 |
R2754 |
T9652 |
T9649 |
prep |
of,43 |
R2755 |
T9653 |
T9652 |
pobj |
Itpr1,of |
R2756 |
T9654 |
T9631 |
punct |
.,revealed |
R2757 |
T9656 |
T9657 |
compound |
Primer,pairs |
R2758 |
T9657 |
T9658 |
nsubjpass |
pairs,designed |
R2759 |
T9659 |
T9658 |
auxpass |
were,designed |
R2760 |
T9660 |
T9661 |
aux |
to,sequence |
R2761 |
T9661 |
T9658 |
advcl |
sequence,designed |
R2762 |
T9662 |
T9661 |
dobj |
each,sequence |
R2763 |
T9663 |
T9662 |
prep |
of,each |
R2764 |
T9664 |
T9665 |
det |
the,exons |
R2765 |
T9665 |
T9663 |
pobj |
exons,of |
R2766 |
T9666 |
T9665 |
compound |
coding,exons |
R2767 |
T9667 |
T9662 |
cc |
and,each |
R2768 |
T9668 |
T9669 |
advmod |
at,50 |
R2769 |
T9669 |
T9671 |
nummod |
50,bp |
R2770 |
T9670 |
T9669 |
advmod |
least,50 |
R2771 |
T9671 |
T9662 |
conj |
bp,each |
R2772 |
T9672 |
T9671 |
prep |
of,bp |
R2773 |
T9673 |
T9674 |
det |
each,sequence |
R2774 |
T9674 |
T9672 |
pobj |
sequence,of |
R2775 |
T9675 |
T9674 |
amod |
flanking,sequence |
R2776 |
T9676 |
T9674 |
amod |
intronic,sequence |
R2777 |
T9677 |
T9662 |
prep |
of,each |
R2778 |
T9678 |
T9677 |
pobj |
Itpr1,of |
R2779 |
T9679 |
T9658 |
punct |
.,designed |
R2780 |
T9681 |
T9682 |
compound |
PCR,amplification |
R2781 |
T9682 |
T9683 |
nsubjpass |
amplification,performed |
R2782 |
T9684 |
T9682 |
prep |
of,amplification |
R2783 |
T9685 |
T9686 |
det |
each,exon |
R2784 |
T9686 |
T9684 |
pobj |
exon,of |
R2785 |
T9687 |
T9683 |
auxpass |
was,performed |
R2786 |
T9688 |
T9683 |
advcl |
using,performed |
R2787 |
T9689 |
T9688 |
dobj |
DNA,using |
R2788 |
T9690 |
T9689 |
prep |
from,DNA |
R2789 |
T9691 |
T9692 |
nummod |
two,mice |
R2790 |
T9692 |
T9690 |
pobj |
mice,from |
R2791 |
T9693 |
T9692 |
amod |
affected,mice |
R2792 |
T9694 |
T9688 |
prep |
as,using |
R2793 |
T9695 |
T9694 |
pobj |
templates,as |
R2794 |
T9696 |
T9683 |
punct |
.,performed |
R2795 |
T9698 |
T9699 |
det |
The,mutation |
R2796 |
T9699 |
T9703 |
nsubjpass |
mutation,confirmed |
R2797 |
T9700 |
T9701 |
compound |
Itpr1Δ18,Δ18 |
R2798 |
T9701 |
T9699 |
compound |
Δ18,mutation |
R2799 |
T9702 |
T9701 |
punct |
/,Δ18 |
R2800 |
T9704 |
T9703 |
auxpass |
was,confirmed |
R2801 |
T9705 |
T9703 |
prep |
by,confirmed |
R2802 |
T9706 |
T9705 |
pobj |
sequencing,by |
R2803 |
T9707 |
T9703 |
prep |
in,confirmed |
R2804 |
T9708 |
T9709 |
det |
all,mice |
R2805 |
T9709 |
T9707 |
pobj |
mice,in |
R2806 |
T9710 |
T9709 |
amod |
affected,mice |
R2807 |
T9711 |
T9712 |
punct |
(,S2 |
R2808 |
T9712 |
T9703 |
parataxis |
S2,confirmed |
R2809 |
T9713 |
T9712 |
compound |
Figure,S2 |
R2810 |
T9714 |
T9712 |
punct |
),S2 |
R2811 |
T9715 |
T9703 |
punct |
.,confirmed |