Id |
Subject |
Object |
Predicate |
Lexical cue |
T8971 |
0-6 |
NN |
denotes |
Genome |
T8972 |
7-11 |
JJ |
denotes |
wide |
T8973 |
6-7 |
HYPH |
denotes |
- |
T8974 |
12-19 |
NN |
denotes |
linkage |
T8975 |
20-22 |
IN |
denotes |
in |
T8976 |
23-27 |
NNS |
denotes |
mice |
T8977 |
27-28 |
. |
denotes |
. |
T8978 |
28-234 |
sentence |
denotes |
One hundred and twenty DNA fragments were amplified across the genome, each selected to contain one or more strain-specific SNPs that would differentiate between C57BL/6J and 129x1/SvJ inbred strains [12]. |
T8979 |
29-32 |
CD |
denotes |
One |
T8980 |
33-40 |
CD |
denotes |
hundred |
T8981 |
56-65 |
NNS |
denotes |
fragments |
T8982 |
41-44 |
CC |
denotes |
and |
T8983 |
45-51 |
CD |
denotes |
twenty |
T8984 |
52-55 |
NN |
denotes |
DNA |
T8985 |
71-80 |
VBN |
denotes |
amplified |
T8986 |
66-70 |
VBD |
denotes |
were |
T8987 |
81-87 |
IN |
denotes |
across |
T8988 |
88-91 |
DT |
denotes |
the |
T8989 |
92-98 |
NN |
denotes |
genome |
T8990 |
98-100 |
, |
denotes |
, |
T8991 |
100-104 |
DT |
denotes |
each |
T8992 |
105-113 |
VBN |
denotes |
selected |
T8993 |
114-116 |
TO |
denotes |
to |
T8994 |
117-124 |
VB |
denotes |
contain |
T8995 |
125-128 |
CD |
denotes |
one |
T8996 |
153-157 |
NNS |
denotes |
SNPs |
T8997 |
129-131 |
CC |
denotes |
or |
T8998 |
132-136 |
JJR |
denotes |
more |
T8999 |
137-143 |
NN |
denotes |
strain |
T9000 |
144-152 |
JJ |
denotes |
specific |
T9001 |
143-144 |
HYPH |
denotes |
- |
T9002 |
158-162 |
WDT |
denotes |
that |
T9003 |
169-182 |
VB |
denotes |
differentiate |
T9004 |
163-168 |
MD |
denotes |
would |
T9005 |
183-190 |
IN |
denotes |
between |
T9006 |
191-196 |
NN |
denotes |
C57BL |
T9007 |
197-199 |
NN |
denotes |
6J |
T9008 |
196-197 |
HYPH |
denotes |
/ |
T9009 |
221-228 |
NNS |
denotes |
strains |
T9010 |
200-203 |
CC |
denotes |
and |
T9011 |
204-209 |
NN |
denotes |
129x1 |
T9012 |
210-213 |
NN |
denotes |
SvJ |
T9013 |
209-210 |
HYPH |
denotes |
/ |
T9014 |
214-220 |
JJ |
denotes |
inbred |
T9015 |
229-230 |
-LRB- |
denotes |
[ |
T9016 |
230-232 |
CD |
denotes |
12 |
T9017 |
232-233 |
-RRB- |
denotes |
] |
T9018 |
233-234 |
. |
denotes |
. |
T9019 |
234-398 |
sentence |
denotes |
Each fragment was initially amplified in 11 affected mice and nine unaffected mice; genotype calling was performed by dye-terminator sequencing of these fragments. |
T9020 |
235-239 |
DT |
denotes |
Each |
T9021 |
240-248 |
NN |
denotes |
fragment |
T9022 |
263-272 |
VBN |
denotes |
amplified |
T9023 |
249-252 |
VBD |
denotes |
was |
T9024 |
253-262 |
RB |
denotes |
initially |
T9025 |
340-349 |
VBN |
denotes |
performed |
T9026 |
273-275 |
IN |
denotes |
in |
T9027 |
276-278 |
CD |
denotes |
11 |
T9028 |
288-292 |
NNS |
denotes |
mice |
T9029 |
279-287 |
VBN |
denotes |
affected |
T9030 |
293-296 |
CC |
denotes |
and |
T9031 |
297-301 |
CD |
denotes |
nine |
T9032 |
313-317 |
NNS |
denotes |
mice |
T9033 |
302-312 |
JJ |
denotes |
unaffected |
T9034 |
317-318 |
: |
denotes |
; |
T9035 |
319-327 |
NN |
denotes |
genotype |
T9036 |
328-335 |
NN |
denotes |
calling |
T9037 |
336-339 |
VBD |
denotes |
was |
T9038 |
350-352 |
IN |
denotes |
by |
T9039 |
353-356 |
NN |
denotes |
dye |
T9040 |
357-367 |
NN |
denotes |
terminator |
T9041 |
356-357 |
HYPH |
denotes |
- |
T9042 |
368-378 |
NN |
denotes |
sequencing |
T9043 |
379-381 |
IN |
denotes |
of |
T9044 |
382-387 |
DT |
denotes |
these |
T9045 |
388-397 |
NNS |
denotes |
fragments |
T9046 |
397-398 |
. |
denotes |
. |
T9047 |
398-599 |
sentence |
denotes |
Linkage analysis using these data was performed using mlink [13], which revealed a positive linkage at Chromosome 6qE1, on the 129x1/SvJ background (two-point LOD score 5.13 at marker 20.MMHAP85FLG2). |
T9048 |
399-406 |
NN |
denotes |
Linkage |
T9049 |
407-415 |
NN |
denotes |
analysis |
T9050 |
437-446 |
VBN |
denotes |
performed |
T9051 |
416-421 |
VBG |
denotes |
using |
T9052 |
422-427 |
DT |
denotes |
these |
T9053 |
428-432 |
NNS |
denotes |
data |
T9054 |
433-436 |
VBD |
denotes |
was |
T9055 |
447-452 |
VBG |
denotes |
using |
T9056 |
453-458 |
NN |
denotes |
mlink |
T9057 |
459-460 |
-LRB- |
denotes |
[ |
T9058 |
460-462 |
CD |
denotes |
13 |
T9059 |
462-463 |
-RRB- |
denotes |
] |
T9060 |
463-465 |
, |
denotes |
, |
T9061 |
465-470 |
WDT |
denotes |
which |
T9062 |
471-479 |
VBD |
denotes |
revealed |
T9063 |
480-481 |
DT |
denotes |
a |
T9064 |
491-498 |
NN |
denotes |
linkage |
T9065 |
482-490 |
JJ |
denotes |
positive |
T9066 |
499-501 |
IN |
denotes |
at |
T9067 |
502-512 |
NN |
denotes |
Chromosome |
T9068 |
513-517 |
NN |
denotes |
6qE1 |
T9069 |
517-519 |
, |
denotes |
, |
T9070 |
519-521 |
IN |
denotes |
on |
T9071 |
522-525 |
DT |
denotes |
the |
T9072 |
536-546 |
NN |
denotes |
background |
T9073 |
526-531 |
NN |
denotes |
129x1 |
T9074 |
532-535 |
NN |
denotes |
SvJ |
T9075 |
531-532 |
HYPH |
denotes |
/ |
T9076 |
547-548 |
-LRB- |
denotes |
( |
T9077 |
562-567 |
NN |
denotes |
score |
T9078 |
548-551 |
CD |
denotes |
two |
T9079 |
552-557 |
NN |
denotes |
point |
T9080 |
551-552 |
HYPH |
denotes |
- |
T9081 |
558-561 |
NN |
denotes |
LOD |
T9082 |
568-572 |
CD |
denotes |
5.13 |
T9083 |
573-575 |
IN |
denotes |
at |
T9084 |
576-582 |
NN |
denotes |
marker |
T9085 |
583-597 |
NN |
denotes |
20.MMHAP85FLG2 |
T9086 |
597-598 |
-RRB- |
denotes |
) |
T9087 |
598-599 |
. |
denotes |
. |
T9088 |
599-746 |
sentence |
denotes |
In an attempt to narrow the disease interval we performed backcross experiments that resulted in the generation of three additional affected mice. |
T9089 |
600-602 |
IN |
denotes |
In |
T9090 |
648-657 |
VBD |
denotes |
performed |
T9091 |
603-605 |
DT |
denotes |
an |
T9092 |
606-613 |
NN |
denotes |
attempt |
T9093 |
614-616 |
TO |
denotes |
to |
T9094 |
617-623 |
VB |
denotes |
narrow |
T9095 |
624-627 |
DT |
denotes |
the |
T9096 |
636-644 |
NN |
denotes |
interval |
T9097 |
628-635 |
NN |
denotes |
disease |
T9098 |
645-647 |
PRP |
denotes |
we |
T9099 |
658-667 |
NN |
denotes |
backcross |
T9100 |
668-679 |
NNS |
denotes |
experiments |
T9101 |
680-684 |
WDT |
denotes |
that |
T9102 |
685-693 |
VBD |
denotes |
resulted |
T9103 |
694-696 |
IN |
denotes |
in |
T9104 |
697-700 |
DT |
denotes |
the |
T9105 |
701-711 |
NN |
denotes |
generation |
T9106 |
712-714 |
IN |
denotes |
of |
T9107 |
715-720 |
CD |
denotes |
three |
T9108 |
741-745 |
NNS |
denotes |
mice |
T9109 |
721-731 |
JJ |
denotes |
additional |
T9110 |
732-740 |
VBN |
denotes |
affected |
T9111 |
745-746 |
. |
denotes |
. |
T9112 |
746-938 |
sentence |
denotes |
Genotyping of all affected mice across the disease-segregating interval revealed flanking recombinants and a candidate region of ~5 Mb, between markers D6Mit37 and 44.MMHAP85FLG5 (Figure S1). |
T9113 |
747-757 |
NN |
denotes |
Genotyping |
T9114 |
819-827 |
VBD |
denotes |
revealed |
T9115 |
758-760 |
IN |
denotes |
of |
T9116 |
761-764 |
DT |
denotes |
all |
T9117 |
774-778 |
NNS |
denotes |
mice |
T9118 |
765-773 |
VBN |
denotes |
affected |
T9119 |
779-785 |
IN |
denotes |
across |
T9120 |
786-789 |
DT |
denotes |
the |
T9121 |
810-818 |
NN |
denotes |
interval |
T9122 |
790-797 |
NN |
denotes |
disease |
T9123 |
798-809 |
VBG |
denotes |
segregating |
T9124 |
797-798 |
HYPH |
denotes |
- |
T9125 |
828-836 |
VBG |
denotes |
flanking |
T9126 |
837-849 |
NNS |
denotes |
recombinants |
T9127 |
850-853 |
CC |
denotes |
and |
T9128 |
854-855 |
DT |
denotes |
a |
T9129 |
866-872 |
NN |
denotes |
region |
T9130 |
856-865 |
NN |
denotes |
candidate |
T9131 |
873-875 |
IN |
denotes |
of |
T9132 |
876-877 |
SYM |
denotes |
~ |
T9133 |
877-878 |
CD |
denotes |
5 |
T9134 |
879-881 |
NN |
denotes |
Mb |
T9135 |
881-883 |
, |
denotes |
, |
T9136 |
883-890 |
IN |
denotes |
between |
T9137 |
891-898 |
NNS |
denotes |
markers |
T9138 |
899-906 |
NN |
denotes |
D6Mit37 |
T9139 |
907-910 |
CC |
denotes |
and |
T9140 |
911-925 |
NN |
denotes |
44.MMHAP85FLG5 |
T9141 |
926-927 |
-LRB- |
denotes |
( |
T9142 |
934-936 |
NN |
denotes |
S1 |
T9143 |
927-933 |
NN |
denotes |
Figure |
T9144 |
936-937 |
-RRB- |
denotes |
) |
T9145 |
937-938 |
. |
denotes |
. |
T9146 |
938-995 |
sentence |
denotes |
This region contains 16 genes and predicted transcripts. |
T9147 |
939-943 |
DT |
denotes |
This |
T9148 |
944-950 |
NN |
denotes |
region |
T9149 |
951-959 |
VBZ |
denotes |
contains |
T9150 |
960-962 |
CD |
denotes |
16 |
T9151 |
963-968 |
NNS |
denotes |
genes |
T9152 |
969-972 |
CC |
denotes |
and |
T9153 |
973-982 |
VBN |
denotes |
predicted |
T9154 |
983-994 |
NNS |
denotes |
transcripts |
T9155 |
994-995 |
. |
denotes |
. |
R2535 |
T8971 |
T8972 |
npadvmod |
Genome,wide |
R2536 |
T8972 |
T8974 |
amod |
wide,linkage |
R2537 |
T8973 |
T8972 |
punct |
-,wide |
R2538 |
T8975 |
T8974 |
prep |
in,linkage |
R2539 |
T8976 |
T8975 |
pobj |
mice,in |
R2540 |
T8977 |
T8974 |
punct |
.,linkage |
R2541 |
T8979 |
T8980 |
compound |
One,hundred |
R2542 |
T8980 |
T8981 |
nummod |
hundred,fragments |
R2543 |
T8981 |
T8985 |
nsubjpass |
fragments,amplified |
R2544 |
T8982 |
T8980 |
cc |
and,hundred |
R2545 |
T8983 |
T8980 |
conj |
twenty,hundred |
R2546 |
T8984 |
T8981 |
compound |
DNA,fragments |
R2547 |
T8986 |
T8985 |
auxpass |
were,amplified |
R2548 |
T8987 |
T8985 |
prep |
across,amplified |
R2549 |
T8988 |
T8989 |
det |
the,genome |
R2550 |
T8989 |
T8987 |
pobj |
genome,across |
R2551 |
T8990 |
T8985 |
punct |
", ",amplified |
R2552 |
T8991 |
T8985 |
npadvmod |
each,amplified |
R2553 |
T8992 |
T8991 |
acl |
selected,each |
R2554 |
T8993 |
T8994 |
aux |
to,contain |
R2555 |
T8994 |
T8992 |
advcl |
contain,selected |
R2556 |
T8995 |
T8996 |
nummod |
one,SNPs |
R2557 |
T8996 |
T8994 |
dobj |
SNPs,contain |
R2558 |
T8997 |
T8995 |
cc |
or,one |
R2559 |
T8998 |
T8995 |
conj |
more,one |
R2560 |
T8999 |
T9000 |
npadvmod |
strain,specific |
R2561 |
T9000 |
T8996 |
amod |
specific,SNPs |
R2562 |
T9001 |
T9000 |
punct |
-,specific |
R2563 |
T9002 |
T9003 |
dep |
that,differentiate |
R2564 |
T9003 |
T8996 |
relcl |
differentiate,SNPs |
R2565 |
T9004 |
T9003 |
aux |
would,differentiate |
R2566 |
T9005 |
T9003 |
prep |
between,differentiate |
R2567 |
T9006 |
T9007 |
nmod |
C57BL,6J |
R2568 |
T9007 |
T9009 |
nmod |
6J,strains |
R2569 |
T9008 |
T9007 |
punct |
/,6J |
R2570 |
T9009 |
T9005 |
pobj |
strains,between |
R2571 |
T9010 |
T9007 |
cc |
and,6J |
R2572 |
T9011 |
T9012 |
compound |
129x1,SvJ |
R2573 |
T9012 |
T9007 |
conj |
SvJ,6J |
R2574 |
T9013 |
T9012 |
punct |
/,SvJ |
R2575 |
T9014 |
T9009 |
amod |
inbred,strains |
R2576 |
T9015 |
T9016 |
punct |
[,12 |
R2577 |
T9016 |
T8985 |
parataxis |
12,amplified |
R2578 |
T9017 |
T9016 |
punct |
],12 |
R2579 |
T9018 |
T8985 |
punct |
.,amplified |
R2580 |
T9020 |
T9021 |
det |
Each,fragment |
R2581 |
T9021 |
T9022 |
nsubjpass |
fragment,amplified |
R2582 |
T9022 |
T9025 |
ccomp |
amplified,performed |
R2583 |
T9023 |
T9022 |
auxpass |
was,amplified |
R2584 |
T9024 |
T9022 |
advmod |
initially,amplified |
R2585 |
T9026 |
T9022 |
prep |
in,amplified |
R2586 |
T9027 |
T9028 |
nummod |
11,mice |
R2587 |
T9028 |
T9026 |
pobj |
mice,in |
R2588 |
T9029 |
T9028 |
amod |
affected,mice |
R2589 |
T9030 |
T9028 |
cc |
and,mice |
R2590 |
T9031 |
T9032 |
nummod |
nine,mice |
R2591 |
T9032 |
T9028 |
conj |
mice,mice |
R2592 |
T9033 |
T9032 |
amod |
unaffected,mice |
R2593 |
T9034 |
T9025 |
punct |
;,performed |
R2594 |
T9035 |
T9036 |
compound |
genotype,calling |
R2595 |
T9036 |
T9025 |
nsubjpass |
calling,performed |
R2596 |
T9037 |
T9025 |
auxpass |
was,performed |
R2597 |
T9038 |
T9025 |
prep |
by,performed |
R2598 |
T9039 |
T9040 |
compound |
dye,terminator |
R2599 |
T9040 |
T9042 |
compound |
terminator,sequencing |
R2600 |
T9041 |
T9040 |
punct |
-,terminator |
R2601 |
T9042 |
T9038 |
pobj |
sequencing,by |
R2602 |
T9043 |
T9042 |
prep |
of,sequencing |
R2603 |
T9044 |
T9045 |
det |
these,fragments |
R2604 |
T9045 |
T9043 |
pobj |
fragments,of |
R2605 |
T9046 |
T9025 |
punct |
.,performed |
R2606 |
T9048 |
T9049 |
compound |
Linkage,analysis |
R2607 |
T9049 |
T9050 |
nsubjpass |
analysis,performed |
R2608 |
T9051 |
T9049 |
acl |
using,analysis |
R2609 |
T9052 |
T9053 |
det |
these,data |
R2610 |
T9053 |
T9051 |
dobj |
data,using |
R2611 |
T9054 |
T9050 |
auxpass |
was,performed |
R2612 |
T9055 |
T9050 |
advcl |
using,performed |
R2613 |
T9056 |
T9055 |
dobj |
mlink,using |
R2614 |
T9057 |
T9058 |
punct |
[,13 |
R2615 |
T9058 |
T9055 |
parataxis |
13,using |
R2616 |
T9059 |
T9058 |
punct |
],13 |
R2617 |
T9060 |
T9050 |
punct |
", ",performed |
R2618 |
T9061 |
T9062 |
dep |
which,revealed |
R2619 |
T9062 |
T9050 |
advcl |
revealed,performed |
R2620 |
T9063 |
T9064 |
det |
a,linkage |
R2621 |
T9064 |
T9062 |
dobj |
linkage,revealed |
R2622 |
T9065 |
T9064 |
amod |
positive,linkage |
R2623 |
T9066 |
T9062 |
prep |
at,revealed |
R2624 |
T9067 |
T9068 |
compound |
Chromosome,6qE1 |
R2625 |
T9068 |
T9066 |
pobj |
6qE1,at |
R2626 |
T9069 |
T9062 |
punct |
", ",revealed |
R2627 |
T9070 |
T9062 |
prep |
on,revealed |
R2628 |
T9071 |
T9072 |
det |
the,background |
R2629 |
T9072 |
T9070 |
pobj |
background,on |
R2630 |
T9073 |
T9074 |
compound |
129x1,SvJ |
R2631 |
T9074 |
T9072 |
compound |
SvJ,background |
R2632 |
T9075 |
T9074 |
punct |
/,SvJ |
R2633 |
T9076 |
T9077 |
punct |
(,score |
R2634 |
T9077 |
T9072 |
parataxis |
score,background |
R2635 |
T9078 |
T9079 |
nummod |
two,point |
R2636 |
T9079 |
T9077 |
compound |
point,score |
R2637 |
T9080 |
T9079 |
punct |
-,point |
R2638 |
T9081 |
T9077 |
compound |
LOD,score |
R2639 |
T9082 |
T9077 |
nummod |
5.13,score |
R2640 |
T9083 |
T9077 |
prep |
at,score |
R2641 |
T9084 |
T9085 |
compound |
marker,20.MMHAP85FLG2 |
R2642 |
T9085 |
T9083 |
pobj |
20.MMHAP85FLG2,at |
R2643 |
T9086 |
T9077 |
punct |
),score |
R2644 |
T9087 |
T9050 |
punct |
.,performed |
R2645 |
T9089 |
T9090 |
prep |
In,performed |
R2646 |
T9091 |
T9092 |
det |
an,attempt |
R2647 |
T9092 |
T9089 |
pobj |
attempt,In |
R2648 |
T9093 |
T9094 |
aux |
to,narrow |
R2649 |
T9094 |
T9092 |
acl |
narrow,attempt |
R2650 |
T9095 |
T9096 |
det |
the,interval |
R2651 |
T9096 |
T9094 |
dobj |
interval,narrow |
R2652 |
T9097 |
T9096 |
compound |
disease,interval |
R2653 |
T9098 |
T9090 |
nsubj |
we,performed |
R2654 |
T9099 |
T9100 |
compound |
backcross,experiments |
R2655 |
T9100 |
T9090 |
dobj |
experiments,performed |
R2656 |
T9101 |
T9102 |
dep |
that,resulted |
R2657 |
T9102 |
T9100 |
relcl |
resulted,experiments |
R2658 |
T9103 |
T9102 |
prep |
in,resulted |
R2659 |
T9104 |
T9105 |
det |
the,generation |
R2660 |
T9105 |
T9103 |
pobj |
generation,in |
R2661 |
T9106 |
T9105 |
prep |
of,generation |
R2662 |
T9107 |
T9108 |
nummod |
three,mice |
R2663 |
T9108 |
T9106 |
pobj |
mice,of |
R2664 |
T9109 |
T9108 |
amod |
additional,mice |
R2665 |
T9110 |
T9108 |
amod |
affected,mice |
R2666 |
T9111 |
T9090 |
punct |
.,performed |
R2667 |
T9113 |
T9114 |
nsubj |
Genotyping,revealed |
R2668 |
T9115 |
T9113 |
prep |
of,Genotyping |
R2669 |
T9116 |
T9117 |
det |
all,mice |
R2670 |
T9117 |
T9115 |
pobj |
mice,of |
R2671 |
T9118 |
T9117 |
amod |
affected,mice |
R2672 |
T9119 |
T9113 |
prep |
across,Genotyping |
R2673 |
T9120 |
T9121 |
det |
the,interval |
R2674 |
T9121 |
T9119 |
pobj |
interval,across |
R2675 |
T9122 |
T9123 |
npadvmod |
disease,segregating |
R2676 |
T9123 |
T9121 |
amod |
segregating,interval |
R2677 |
T9124 |
T9123 |
punct |
-,segregating |
R2678 |
T9125 |
T9126 |
amod |
flanking,recombinants |
R2679 |
T9126 |
T9114 |
dobj |
recombinants,revealed |
R2680 |
T9127 |
T9126 |
cc |
and,recombinants |
R2681 |
T9128 |
T9129 |
det |
a,region |
R2682 |
T9129 |
T9126 |
conj |
region,recombinants |
R2683 |
T9130 |
T9129 |
compound |
candidate,region |
R2684 |
T9131 |
T9129 |
prep |
of,region |
R2685 |
T9132 |
T9133 |
punct |
~,5 |
R2686 |
T9133 |
T9134 |
nummod |
5,Mb |
R2687 |
T9134 |
T9131 |
pobj |
Mb,of |
R2688 |
T9135 |
T9114 |
punct |
", ",revealed |
R2689 |
T9136 |
T9114 |
prep |
between,revealed |
R2690 |
T9137 |
T9138 |
compound |
markers,D6Mit37 |
R2691 |
T9138 |
T9136 |
pobj |
D6Mit37,between |
R2692 |
T9139 |
T9138 |
cc |
and,D6Mit37 |
R2693 |
T9140 |
T9138 |
conj |
44.MMHAP85FLG5,D6Mit37 |
R2694 |
T9141 |
T9142 |
punct |
(,S1 |
R2695 |
T9142 |
T9114 |
parataxis |
S1,revealed |
R2696 |
T9143 |
T9142 |
compound |
Figure,S1 |
R2697 |
T9144 |
T9142 |
punct |
),S1 |
R2698 |
T9145 |
T9114 |
punct |
.,revealed |
R2699 |
T9147 |
T9148 |
det |
This,region |
R2700 |
T9148 |
T9149 |
nsubj |
region,contains |
R2701 |
T9150 |
T9151 |
nummod |
16,genes |
R2702 |
T9151 |
T9149 |
dobj |
genes,contains |
R2703 |
T9152 |
T9151 |
cc |
and,genes |
R2704 |
T9153 |
T9154 |
amod |
predicted,transcripts |
R2705 |
T9154 |
T9151 |
conj |
transcripts,genes |
R2706 |
T9155 |
T9149 |
punct |
.,contains |