Id |
Subject |
Object |
Predicate |
Lexical cue |
T8381 |
0-2 |
PRP |
denotes |
We |
T8382 |
3-7 |
VBP |
denotes |
show |
T8383 |
8-12 |
RB |
denotes |
here |
T8384 |
13-16 |
DT |
denotes |
the |
T8385 |
17-24 |
NN |
denotes |
utility |
T8386 |
25-27 |
IN |
denotes |
of |
T8387 |
28-41 |
VBG |
denotes |
investigating |
T8388 |
42-53 |
JJ |
denotes |
spontaneous |
T8389 |
60-69 |
NNS |
denotes |
mutations |
T8390 |
54-59 |
NN |
denotes |
mouse |
T8391 |
70-72 |
IN |
denotes |
in |
T8392 |
73-86 |
VBG |
denotes |
understanding |
T8393 |
87-92 |
JJ |
denotes |
human |
T8394 |
93-100 |
NN |
denotes |
disease |
T8395 |
100-101 |
. |
denotes |
. |
T8396 |
101-348 |
sentence |
denotes |
Currently, the small number of aged Itpr1wt/Δ18 animals precludes us from examining these mice for subtle signs and symptoms similar to those seen in SCA15 patients; however, these mice are clearly of interest to us as a potential model of SCA15. |
T8397 |
102-111 |
RB |
denotes |
Currently |
T8398 |
158-167 |
VBZ |
denotes |
precludes |
T8399 |
111-113 |
, |
denotes |
, |
T8400 |
113-116 |
DT |
denotes |
the |
T8401 |
123-129 |
NN |
denotes |
number |
T8402 |
117-122 |
JJ |
denotes |
small |
T8403 |
130-132 |
IN |
denotes |
of |
T8404 |
133-137 |
VBN |
denotes |
aged |
T8405 |
150-157 |
NNS |
denotes |
animals |
T8406 |
138-145 |
NN |
denotes |
Itpr1wt |
T8407 |
146-149 |
NN |
denotes |
Δ18 |
T8408 |
145-146 |
HYPH |
denotes |
/ |
T8409 |
288-291 |
VBP |
denotes |
are |
T8410 |
168-170 |
PRP |
denotes |
us |
T8411 |
171-175 |
IN |
denotes |
from |
T8412 |
176-185 |
VBG |
denotes |
examining |
T8413 |
186-191 |
DT |
denotes |
these |
T8414 |
192-196 |
NNS |
denotes |
mice |
T8415 |
197-200 |
IN |
denotes |
for |
T8416 |
201-207 |
JJ |
denotes |
subtle |
T8417 |
208-213 |
NNS |
denotes |
signs |
T8418 |
214-217 |
CC |
denotes |
and |
T8419 |
218-226 |
NNS |
denotes |
symptoms |
T8420 |
227-234 |
JJ |
denotes |
similar |
T8421 |
235-237 |
IN |
denotes |
to |
T8422 |
238-243 |
DT |
denotes |
those |
T8423 |
244-248 |
VBN |
denotes |
seen |
T8424 |
249-251 |
IN |
denotes |
in |
T8425 |
252-257 |
NN |
denotes |
SCA15 |
T8426 |
258-266 |
NNS |
denotes |
patients |
T8427 |
266-267 |
: |
denotes |
; |
T8428 |
268-275 |
RB |
denotes |
however |
T8429 |
275-277 |
, |
denotes |
, |
T8430 |
277-282 |
DT |
denotes |
these |
T8431 |
283-287 |
NNS |
denotes |
mice |
T8432 |
292-299 |
RB |
denotes |
clearly |
T8433 |
300-302 |
IN |
denotes |
of |
T8434 |
303-311 |
NN |
denotes |
interest |
T8435 |
312-314 |
IN |
denotes |
to |
T8436 |
315-317 |
PRP |
denotes |
us |
T8437 |
318-320 |
IN |
denotes |
as |
T8438 |
321-322 |
DT |
denotes |
a |
T8439 |
333-338 |
NN |
denotes |
model |
T8440 |
323-332 |
JJ |
denotes |
potential |
T8441 |
339-341 |
IN |
denotes |
of |
T8442 |
342-347 |
NN |
denotes |
SCA15 |
T8443 |
347-348 |
. |
denotes |
. |
T8444 |
348-493 |
sentence |
denotes |
These data also demonstrate that genome-wide SNP assay can facilitate rapid detection of structural genomic mutations that may underlie disease. |
T8445 |
349-354 |
DT |
denotes |
These |
T8446 |
355-359 |
NNS |
denotes |
data |
T8447 |
365-376 |
VBP |
denotes |
demonstrate |
T8448 |
360-364 |
RB |
denotes |
also |
T8449 |
377-381 |
IN |
denotes |
that |
T8450 |
408-418 |
VB |
denotes |
facilitate |
T8451 |
382-388 |
NN |
denotes |
genome |
T8452 |
389-393 |
JJ |
denotes |
wide |
T8453 |
388-389 |
HYPH |
denotes |
- |
T8454 |
398-403 |
NN |
denotes |
assay |
T8455 |
394-397 |
NN |
denotes |
SNP |
T8456 |
404-407 |
MD |
denotes |
can |
T8457 |
419-424 |
JJ |
denotes |
rapid |
T8458 |
425-434 |
NN |
denotes |
detection |
T8459 |
435-437 |
IN |
denotes |
of |
T8460 |
438-448 |
JJ |
denotes |
structural |
T8461 |
457-466 |
NNS |
denotes |
mutations |
T8462 |
449-456 |
JJ |
denotes |
genomic |
T8463 |
467-471 |
WDT |
denotes |
that |
T8464 |
476-484 |
VB |
denotes |
underlie |
T8465 |
472-475 |
MD |
denotes |
may |
T8466 |
485-492 |
NN |
denotes |
disease |
T8467 |
492-493 |
. |
denotes |
. |
T8468 |
493-609 |
sentence |
denotes |
The data provided by these approaches provide compelling evidence that heterozygous deletion of ITPR1 causes SCA15. |
T8469 |
494-497 |
DT |
denotes |
The |
T8470 |
498-502 |
NNS |
denotes |
data |
T8471 |
532-539 |
VBP |
denotes |
provide |
T8472 |
503-511 |
VBN |
denotes |
provided |
T8473 |
512-514 |
IN |
denotes |
by |
T8474 |
515-520 |
DT |
denotes |
these |
T8475 |
521-531 |
NNS |
denotes |
approaches |
T8476 |
540-550 |
JJ |
denotes |
compelling |
T8477 |
551-559 |
NN |
denotes |
evidence |
T8478 |
560-564 |
IN |
denotes |
that |
T8479 |
596-602 |
VBZ |
denotes |
causes |
T8480 |
565-577 |
JJ |
denotes |
heterozygous |
T8481 |
578-586 |
NN |
denotes |
deletion |
T8482 |
587-589 |
IN |
denotes |
of |
T8483 |
590-595 |
NN |
denotes |
ITPR1 |
T8484 |
603-608 |
NN |
denotes |
SCA15 |
T8485 |
608-609 |
. |
denotes |
. |
T8486 |
609-1001 |
sentence |
denotes |
Clearly, sequence analysis of ITPR1 in potential SCA15 cases may provide additional insight into the disease, particularly if a stop mutation were to be identified; however, the mutational mechanism noted here means that standard sequencing approaches alone are insufficient to confidently rule out ITPR1 mutation as a cause of disease: a comprehensive gene dosage approach is also required. |
T8487 |
610-617 |
RB |
denotes |
Clearly |
T8488 |
675-682 |
VB |
denotes |
provide |
T8489 |
617-619 |
, |
denotes |
, |
T8490 |
619-627 |
NN |
denotes |
sequence |
T8491 |
628-636 |
NN |
denotes |
analysis |
T8492 |
637-639 |
IN |
denotes |
of |
T8493 |
640-645 |
NN |
denotes |
ITPR1 |
T8494 |
646-648 |
IN |
denotes |
in |
T8495 |
649-658 |
JJ |
denotes |
potential |
T8496 |
665-670 |
NNS |
denotes |
cases |
T8497 |
659-664 |
NN |
denotes |
SCA15 |
T8498 |
671-674 |
MD |
denotes |
may |
T8499 |
820-825 |
VBZ |
denotes |
means |
T8500 |
683-693 |
JJ |
denotes |
additional |
T8501 |
694-701 |
NN |
denotes |
insight |
T8502 |
702-706 |
IN |
denotes |
into |
T8503 |
707-710 |
DT |
denotes |
the |
T8504 |
711-718 |
NN |
denotes |
disease |
T8505 |
718-720 |
, |
denotes |
, |
T8506 |
720-732 |
RB |
denotes |
particularly |
T8507 |
752-756 |
VBD |
denotes |
were |
T8508 |
733-735 |
IN |
denotes |
if |
T8509 |
736-737 |
DT |
denotes |
a |
T8510 |
743-751 |
NN |
denotes |
mutation |
T8511 |
738-742 |
NN |
denotes |
stop |
T8512 |
757-759 |
TO |
denotes |
to |
T8513 |
763-773 |
VBN |
denotes |
identified |
T8514 |
760-762 |
VB |
denotes |
be |
T8515 |
773-774 |
: |
denotes |
; |
T8516 |
775-782 |
RB |
denotes |
however |
T8517 |
782-784 |
, |
denotes |
, |
T8518 |
784-787 |
DT |
denotes |
the |
T8519 |
799-808 |
NN |
denotes |
mechanism |
T8520 |
788-798 |
JJ |
denotes |
mutational |
T8521 |
809-814 |
VBN |
denotes |
noted |
T8522 |
815-819 |
RB |
denotes |
here |
T8523 |
826-830 |
IN |
denotes |
that |
T8524 |
992-1000 |
VBN |
denotes |
required |
T8525 |
831-839 |
JJ |
denotes |
standard |
T8526 |
851-861 |
NNS |
denotes |
approaches |
T8527 |
840-850 |
NN |
denotes |
sequencing |
T8528 |
868-871 |
VBP |
denotes |
are |
T8529 |
862-867 |
RB |
denotes |
alone |
T8530 |
872-884 |
JJ |
denotes |
insufficient |
T8531 |
885-887 |
TO |
denotes |
to |
T8532 |
900-904 |
VB |
denotes |
rule |
T8533 |
888-899 |
RB |
denotes |
confidently |
T8534 |
905-908 |
RP |
denotes |
out |
T8535 |
909-914 |
NN |
denotes |
ITPR1 |
T8536 |
915-923 |
NN |
denotes |
mutation |
T8537 |
924-926 |
IN |
denotes |
as |
T8538 |
927-928 |
DT |
denotes |
a |
T8539 |
929-934 |
NN |
denotes |
cause |
T8540 |
935-937 |
IN |
denotes |
of |
T8541 |
938-945 |
NN |
denotes |
disease |
T8542 |
945-947 |
: |
denotes |
: |
T8543 |
947-948 |
DT |
denotes |
a |
T8544 |
975-983 |
NN |
denotes |
approach |
T8545 |
949-962 |
JJ |
denotes |
comprehensive |
T8546 |
963-967 |
NN |
denotes |
gene |
T8547 |
968-974 |
NN |
denotes |
dosage |
T8548 |
984-986 |
VBZ |
denotes |
is |
T8549 |
987-991 |
RB |
denotes |
also |
T8550 |
1000-1001 |
. |
denotes |
. |
T8551 |
1001-1221 |
sentence |
denotes |
Given that SCA16 and autosomal dominant congenital nonprogressive ataxia have both recently been mapped to regions overlapping with the SCA15 locus [10,11], ITPR1 is a gene of importance for screening in these families. |
T8552 |
1002-1007 |
VBN |
denotes |
Given |
T8553 |
1165-1167 |
VBZ |
denotes |
is |
T8554 |
1008-1012 |
IN |
denotes |
that |
T8555 |
1099-1105 |
VBN |
denotes |
mapped |
T8556 |
1013-1018 |
NN |
denotes |
SCA16 |
T8557 |
1019-1022 |
CC |
denotes |
and |
T8558 |
1023-1032 |
JJ |
denotes |
autosomal |
T8559 |
1068-1074 |
NN |
denotes |
ataxia |
T8560 |
1033-1041 |
JJ |
denotes |
dominant |
T8561 |
1042-1052 |
JJ |
denotes |
congenital |
T8562 |
1053-1067 |
JJ |
denotes |
nonprogressive |
T8563 |
1075-1079 |
VBP |
denotes |
have |
T8564 |
1080-1084 |
DT |
denotes |
both |
T8565 |
1085-1093 |
RB |
denotes |
recently |
T8566 |
1094-1098 |
VBN |
denotes |
been |
T8567 |
1106-1108 |
IN |
denotes |
to |
T8568 |
1109-1116 |
NNS |
denotes |
regions |
T8569 |
1117-1128 |
VBG |
denotes |
overlapping |
T8570 |
1129-1133 |
IN |
denotes |
with |
T8571 |
1134-1137 |
DT |
denotes |
the |
T8572 |
1144-1149 |
NN |
denotes |
locus |
T8573 |
1138-1143 |
NN |
denotes |
SCA15 |
T8574 |
1150-1151 |
-LRB- |
denotes |
[ |
T8575 |
1154-1156 |
CD |
denotes |
11 |
T8576 |
1151-1153 |
CD |
denotes |
10 |
T8577 |
1153-1154 |
, |
denotes |
, |
T8578 |
1156-1157 |
-RRB- |
denotes |
] |
T8579 |
1157-1159 |
, |
denotes |
, |
T8580 |
1159-1164 |
NN |
denotes |
ITPR1 |
T8581 |
1168-1169 |
DT |
denotes |
a |
T8582 |
1170-1174 |
NN |
denotes |
gene |
T8583 |
1175-1177 |
IN |
denotes |
of |
T8584 |
1178-1188 |
NN |
denotes |
importance |
T8585 |
1189-1192 |
IN |
denotes |
for |
T8586 |
1193-1202 |
NN |
denotes |
screening |
T8587 |
1203-1205 |
IN |
denotes |
in |
T8588 |
1206-1211 |
DT |
denotes |
these |
T8589 |
1212-1220 |
NNS |
denotes |
families |
T8590 |
1220-1221 |
. |
denotes |
. |
T8591 |
1221-1360 |
sentence |
denotes |
These data add weight to a role for aberrant intracellular Ca2+ signaling in Purkinje cells in the pathogenesis of spinocerebellar ataxia. |
T8592 |
1222-1227 |
DT |
denotes |
These |
T8593 |
1228-1232 |
NNS |
denotes |
data |
T8594 |
1233-1236 |
VBP |
denotes |
add |
T8595 |
1237-1243 |
NN |
denotes |
weight |
T8596 |
1244-1246 |
IN |
denotes |
to |
T8597 |
1247-1248 |
DT |
denotes |
a |
T8598 |
1249-1253 |
NN |
denotes |
role |
T8599 |
1254-1257 |
IN |
denotes |
for |
T8600 |
1258-1266 |
JJ |
denotes |
aberrant |
T8601 |
1286-1295 |
NN |
denotes |
signaling |
T8602 |
1267-1280 |
JJ |
denotes |
intracellular |
T8603 |
1281-1285 |
NN |
denotes |
Ca2+ |
T8604 |
1296-1298 |
IN |
denotes |
in |
T8605 |
1299-1307 |
NNP |
denotes |
Purkinje |
T8606 |
1308-1313 |
NNS |
denotes |
cells |
T8607 |
1314-1316 |
IN |
denotes |
in |
T8608 |
1317-1320 |
DT |
denotes |
the |
T8609 |
1321-1333 |
NN |
denotes |
pathogenesis |
T8610 |
1334-1336 |
IN |
denotes |
of |
T8611 |
1337-1352 |
JJ |
denotes |
spinocerebellar |
T8612 |
1353-1359 |
NN |
denotes |
ataxia |
T8613 |
1359-1360 |
. |
denotes |
. |
R2230 |
T8383 |
T8382 |
advmod |
here,show |
R2232 |
T8384 |
T8385 |
det |
the,utility |
R2233 |
T8385 |
T8382 |
dobj |
utility,show |
R2236 |
T8386 |
T8385 |
prep |
of,utility |
R2238 |
T8387 |
T8386 |
pcomp |
investigating,of |
R2239 |
T8388 |
T8389 |
amod |
spontaneous,mutations |
R2240 |
T8389 |
T8387 |
dobj |
mutations,investigating |
R2242 |
T8390 |
T8389 |
compound |
mouse,mutations |
R2243 |
T8391 |
T8387 |
prep |
in,investigating |
R2244 |
T8392 |
T8391 |
pcomp |
understanding,in |
R2246 |
T8393 |
T8394 |
amod |
human,disease |
R2247 |
T8394 |
T8392 |
dobj |
disease,understanding |
R2249 |
T8395 |
T8382 |
punct |
.,show |
R2251 |
T8397 |
T8398 |
advmod |
Currently,precludes |
R2252 |
T8398 |
T8409 |
ccomp |
precludes,are |
R2253 |
T8399 |
T8398 |
punct |
", ",precludes |
R2255 |
T8400 |
T8401 |
det |
the,number |
R2256 |
T8401 |
T8398 |
nsubj |
number,precludes |
R2258 |
T8402 |
T8401 |
amod |
small,number |
R2259 |
T8403 |
T8401 |
prep |
of,number |
R2260 |
T8404 |
T8405 |
amod |
aged,animals |
R2262 |
T8405 |
T8403 |
pobj |
animals,of |
R2263 |
T8406 |
T8407 |
compound |
Itpr1wt,Δ18 |
R2264 |
T8407 |
T8405 |
compound |
Δ18,animals |
R2266 |
T8408 |
T8407 |
punct |
/,Δ18 |
R2267 |
T8410 |
T8398 |
dobj |
us,precludes |
R2269 |
T8411 |
T8398 |
prep |
from,precludes |
R2270 |
T8412 |
T8411 |
pcomp |
examining,from |
R2271 |
T8413 |
T8414 |
det |
these,mice |
R2272 |
T8414 |
T8412 |
dobj |
mice,examining |
R2273 |
T8415 |
T8412 |
prep |
for,examining |
R2275 |
T8416 |
T8417 |
amod |
subtle,signs |
R2276 |
T8417 |
T8415 |
pobj |
signs,for |
R2277 |
T8418 |
T8417 |
cc |
and,signs |
R2279 |
T8419 |
T8417 |
conj |
symptoms,signs |
R2280 |
T8420 |
T8417 |
amod |
similar,signs |
R2281 |
T8421 |
T8420 |
prep |
to,similar |
R2283 |
T8422 |
T8421 |
pobj |
those,to |
R2284 |
T8423 |
T8422 |
acl |
seen,those |
R2286 |
T8424 |
T8423 |
prep |
in,seen |
R2287 |
T8425 |
T8426 |
compound |
SCA15,patients |
R2288 |
T8426 |
T8424 |
pobj |
patients,in |
R2290 |
T8427 |
T8409 |
punct |
;,are |
R2291 |
T8428 |
T8409 |
advmod |
however,are |
R2292 |
T8429 |
T8409 |
punct |
", ",are |
R2294 |
T8430 |
T8431 |
det |
these,mice |
R2295 |
T8431 |
T8409 |
nsubj |
mice,are |
R2296 |
T8432 |
T8409 |
advmod |
clearly,are |
R2297 |
T8433 |
T8409 |
prep |
of,are |
R2299 |
T8434 |
T8433 |
pobj |
interest,of |
R2300 |
T8435 |
T8434 |
prep |
to,interest |
R2302 |
T8436 |
T8435 |
pobj |
us,to |
R2303 |
T8437 |
T8409 |
prep |
as,are |
R2304 |
T8438 |
T8439 |
det |
a,model |
R2306 |
T8439 |
T8437 |
pobj |
model,as |
R2307 |
T8440 |
T8439 |
amod |
potential,model |
R2308 |
T8441 |
T8439 |
prep |
of,model |
R2310 |
T8442 |
T8441 |
pobj |
SCA15,of |
R2311 |
T8443 |
T8409 |
punct |
.,are |
R2313 |
T8445 |
T8446 |
det |
These,data |
R2314 |
T8446 |
T8447 |
nsubj |
data,demonstrate |
R2316 |
T8448 |
T8447 |
advmod |
also,demonstrate |
R2318 |
T8449 |
T8450 |
mark |
that,facilitate |
R2319 |
T8450 |
T8447 |
ccomp |
facilitate,demonstrate |
R2320 |
T8451 |
T8452 |
npadvmod |
genome,wide |
R2321 |
T8452 |
T8454 |
amod |
wide,assay |
R2322 |
T8453 |
T8452 |
punct |
-,wide |
R2323 |
T8454 |
T8450 |
nsubj |
assay,facilitate |
R2325 |
T8455 |
T8454 |
compound |
SNP,assay |
R2326 |
T8456 |
T8450 |
aux |
can,facilitate |
R2327 |
T8457 |
T8458 |
amod |
rapid,detection |
R2328 |
T8458 |
T8450 |
dobj |
detection,facilitate |
R2330 |
T8459 |
T8458 |
prep |
of,detection |
R2331 |
T8460 |
T8461 |
amod |
structural,mutations |
R2332 |
T8461 |
T8459 |
pobj |
mutations,of |
R2334 |
T8462 |
T8461 |
amod |
genomic,mutations |
R2335 |
T8463 |
T8464 |
dep |
that,underlie |
R2337 |
T8464 |
T8461 |
relcl |
underlie,mutations |
R2338 |
T8465 |
T8464 |
aux |
may,underlie |
R2339 |
T8466 |
T8464 |
dobj |
disease,underlie |
R2341 |
T8467 |
T8447 |
punct |
.,demonstrate |
R2343 |
T8469 |
T8470 |
det |
The,data |
R2344 |
T8470 |
T8471 |
nsubj |
data,provide |
R2346 |
T8472 |
T8470 |
acl |
provided,data |
R2349 |
T8473 |
T8472 |
agent |
by,provided |
R2350 |
T8474 |
T8475 |
det |
these,approaches |
R2352 |
T8475 |
T8473 |
pobj |
approaches,by |
R2353 |
T8476 |
T8477 |
amod |
compelling,evidence |
R2355 |
T8477 |
T8471 |
dobj |
evidence,provide |
R2356 |
T8478 |
T8479 |
mark |
that,causes |
R2357 |
T8479 |
T8477 |
acl |
causes,evidence |
R2359 |
T8480 |
T8481 |
amod |
heterozygous,deletion |
R2362 |
T8481 |
T8479 |
nsubj |
deletion,causes |
R2364 |
T8482 |
T8481 |
prep |
of,deletion |
R2365 |
T8483 |
T8482 |
pobj |
ITPR1,of |
R2366 |
T8484 |
T8479 |
dobj |
SCA15,causes |
R2368 |
T8485 |
T8471 |
punct |
.,provide |
R2370 |
T8487 |
T8488 |
advmod |
Clearly,provide |
R2371 |
T8488 |
T8499 |
ccomp |
provide,means |
R2375 |
T8489 |
T8488 |
punct |
", ",provide |
R2377 |
T8490 |
T8491 |
compound |
sequence,analysis |
R2378 |
T8491 |
T8488 |
nsubj |
analysis,provide |
R2380 |
T8492 |
T8491 |
prep |
of,analysis |
R2381 |
T8493 |
T8492 |
pobj |
ITPR1,of |
R2382 |
T8494 |
T8493 |
prep |
in,ITPR1 |
R2384 |
T8495 |
T8496 |
amod |
potential,cases |
R2385 |
T8496 |
T8494 |
pobj |
cases,in |
R2387 |
T8497 |
T8496 |
compound |
SCA15,cases |
R2388 |
T8498 |
T8488 |
aux |
may,provide |
R2390 |
T8500 |
T8501 |
amod |
additional,insight |
R2391 |
T8501 |
T8488 |
dobj |
insight,provide |
R2393 |
T8502 |
T8501 |
prep |
into,insight |
R2394 |
T8503 |
T8504 |
det |
the,disease |
R2395 |
T8504 |
T8502 |
pobj |
disease,into |
R2397 |
T8505 |
T8488 |
punct |
", ",provide |
R2398 |
T8506 |
T8507 |
advmod |
particularly,were |
R2399 |
T8507 |
T8488 |
advcl |
were,provide |
R2401 |
T8508 |
T8507 |
mark |
if,were |
R2402 |
T8509 |
T8510 |
det |
a,mutation |
R2404 |
T8510 |
T8507 |
nsubj |
mutation,were |
R2405 |
T8511 |
T8510 |
compound |
stop,mutation |
R2406 |
T8512 |
T8513 |
aux |
to,identified |
R2408 |
T8513 |
T8507 |
xcomp |
identified,were |
R2409 |
T8514 |
T8513 |
auxpass |
be,identified |
R2410 |
T8515 |
T8499 |
punct |
;,means |
R2412 |
T8516 |
T8499 |
advmod |
however,means |
R2413 |
T8517 |
T8499 |
punct |
", ",means |
R2415 |
T8518 |
T8519 |
det |
the,mechanism |
R2416 |
T8519 |
T8499 |
nsubj |
mechanism,means |
R2417 |
T8520 |
T8519 |
amod |
mutational,mechanism |
R2419 |
T8521 |
T8519 |
acl |
noted,mechanism |
R2420 |
T8522 |
T8521 |
advmod |
here,noted |
R2422 |
T8523 |
T8524 |
mark |
that,required |
R2423 |
T8524 |
T8499 |
ccomp |
required,means |
R2424 |
T8525 |
T8526 |
amod |
standard,approaches |
R2425 |
T8526 |
T8528 |
nsubj |
approaches,are |
R2426 |
T8527 |
T8526 |
compound |
sequencing,approaches |
R2427 |
T8528 |
T8524 |
ccomp |
are,required |
R2429 |
T8529 |
T8526 |
advmod |
alone,approaches |
R2430 |
T8530 |
T8528 |
acomp |
insufficient,are |
R2432 |
T8531 |
T8532 |
aux |
to,rule |
R2433 |
T8532 |
T8530 |
xcomp |
rule,insufficient |
R2434 |
T8533 |
T8532 |
advmod |
confidently,rule |
R2436 |
T8534 |
T8532 |
prt |
out,rule |
R2437 |
T8535 |
T8536 |
compound |
ITPR1,mutation |
R2438 |
T8536 |
T8532 |
dobj |
mutation,rule |
R2440 |
T8537 |
T8532 |
prep |
as,rule |
R2441 |
T8538 |
T8539 |
det |
a,cause |
R2443 |
T8539 |
T8537 |
pobj |
cause,as |
R2444 |
T8540 |
T8539 |
prep |
of,cause |
R2446 |
T8541 |
T8540 |
pobj |
disease,of |
R2447 |
T8542 |
T8524 |
punct |
: ,required |
R2449 |
T8543 |
T8544 |
det |
a,approach |
R2450 |
T8544 |
T8524 |
nsubjpass |
approach,required |
R2451 |
T8545 |
T8544 |
amod |
comprehensive,approach |
R2452 |
T8546 |
T8547 |
compound |
gene,dosage |
R2454 |
T8547 |
T8544 |
compound |
dosage,approach |
R2455 |
T8548 |
T8524 |
auxpass |
is,required |
R2456 |
T8549 |
T8524 |
advmod |
also,required |
R2457 |
T8550 |
T8499 |
punct |
.,means |
R2459 |
T8552 |
T8553 |
prep |
Given,is |
R2461 |
T8554 |
T8555 |
mark |
that,mapped |
R2464 |
T8555 |
T8552 |
pcomp |
mapped,Given |
R2465 |
T8556 |
T8555 |
nsubjpass |
SCA16,mapped |
R2466 |
T8557 |
T8556 |
cc |
and,SCA16 |
R2468 |
T8558 |
T8559 |
amod |
autosomal,ataxia |
R2469 |
T8559 |
T8556 |
conj |
ataxia,SCA16 |
R2471 |
T8560 |
T8559 |
amod |
dominant,ataxia |
R2472 |
T8561 |
T8559 |
amod |
congenital,ataxia |
R2474 |
T8562 |
T8559 |
amod |
nonprogressive,ataxia |
R2475 |
T8563 |
T8555 |
aux |
have,mapped |
R2476 |
T8564 |
T8555 |
dep |
both,mapped |
R2477 |
T8565 |
T8555 |
advmod |
recently,mapped |
R2478 |
T8566 |
T8555 |
auxpass |
been,mapped |
R2480 |
T8567 |
T8555 |
prep |
to,mapped |
R2481 |
T8568 |
T8567 |
pobj |
regions,to |
R2482 |
T8569 |
T8568 |
acl |
overlapping,regions |
R2484 |
T8570 |
T8569 |
prep |
with,overlapping |
R2485 |
T8571 |
T8572 |
det |
the,locus |
R2486 |
T8572 |
T8570 |
pobj |
locus,with |
R2488 |
T8573 |
T8572 |
compound |
SCA15,locus |
R2489 |
T8574 |
T8575 |
punct |
[,11 |
R2491 |
T8575 |
T8555 |
parataxis |
11,mapped |
R2492 |
T8576 |
T8575 |
nummod |
10,11 |
R2493 |
T8577 |
T8575 |
punct |
",",11 |
R2495 |
T8578 |
T8575 |
punct |
],11 |
R2496 |
T8579 |
T8553 |
punct |
", ",is |
R2497 |
T8580 |
T8553 |
nsubj |
ITPR1,is |
R2499 |
T8581 |
T8582 |
det |
a,gene |
R2500 |
T8582 |
T8553 |
attr |
gene,is |
R2502 |
T8583 |
T8582 |
prep |
of,gene |
R2503 |
T8584 |
T8583 |
pobj |
importance,of |
R2504 |
T8585 |
T8584 |
prep |
for,importance |
R2505 |
T8586 |
T8585 |
pobj |
screening,for |
R2507 |
T8587 |
T8553 |
prep |
in,is |
R2508 |
T8588 |
T8589 |
det |
these,families |
R2509 |
T8589 |
T8587 |
pobj |
families,in |
R2511 |
T8590 |
T8553 |
punct |
.,is |
R2513 |
T8592 |
T8593 |
det |
These,data |
R2514 |
T8593 |
T8594 |
nsubj |
data,add |
R2515 |
T8381 |
T8382 |
nsubj |
We,show |
R2516 |
T8595 |
T8594 |
dobj |
weight,add |
R2517 |
T8596 |
T8594 |
prep |
to,add |
R2518 |
T8597 |
T8598 |
det |
a,role |
R2519 |
T8598 |
T8596 |
pobj |
role,to |
R2520 |
T8599 |
T8598 |
prep |
for,role |
R2521 |
T8600 |
T8601 |
amod |
aberrant,signaling |
R2522 |
T8601 |
T8599 |
pobj |
signaling,for |
R2523 |
T8602 |
T8601 |
amod |
intracellular,signaling |
R2524 |
T8603 |
T8601 |
compound |
Ca2+,signaling |
R2525 |
T8604 |
T8601 |
prep |
in,signaling |
R2526 |
T8605 |
T8606 |
compound |
Purkinje,cells |
R2527 |
T8606 |
T8604 |
pobj |
cells,in |
R2528 |
T8607 |
T8598 |
prep |
in,role |
R2529 |
T8608 |
T8609 |
det |
the,pathogenesis |
R2530 |
T8609 |
T8607 |
pobj |
pathogenesis,in |
R2531 |
T8610 |
T8609 |
prep |
of,pathogenesis |
R2532 |
T8611 |
T8612 |
amod |
spinocerebellar,ataxia |
R2533 |
T8612 |
T8610 |
pobj |
ataxia,of |
R2534 |
T8613 |
T8594 |
punct |
.,add |