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PMC:1892049 / 14709-15829 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6248 45-53 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T6249 57-62 PR_EXT:000015827 denotes SUMF1
T6250 64-72 SO_EXT:sequence_coding_function denotes encoding
T6251 73-82 GO_EXT:0008484 denotes sulfatase
T6252 73-101 PR_EXT:000015827 denotes sulfatase modifying factor 1
T6253 83-92 SO_EXT:sequence_alteration_process denotes modifying
T6254 156-164 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T6255 168-173 PR_EXT:000015827 denotes SUMF1
T6256 185-194 GO:0030849 denotes autosomal
T6257 214-223 GO_EXT:0008484 denotes sulfatase
T6258 238-247 GO:0008152 denotes metabolic
T6259 433-442 GO_EXT:0008484 denotes sulfatase
T6260 467-475 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T6261 479-484 PR_EXT:000009158 denotes ITPR1
T6262 488-500 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biologically
T6263 537-544 CHEBI_PR_EXT:protein denotes protein
T6264 555-564 GO:0010467 denotes expressed
T6265 568-582 CL:0000121 denotes Purkinje cells
T6266 577-582 CL_GO_EXT:cell denotes cells
T6267 607-611 NCBITaxon:10088 denotes mice
T6268 617-625 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T6269 675-679 CHEBI:29108 denotes Ca2+
T6270 675-689 GO:0019722 denotes Ca2+ signaling
T6271 847-854 CHEBI_PR_EXT:protein denotes protein
T6272 865-870 PR_EXT:000009158 denotes ITPR1
T6273 874-892 NCBITaxon:10376 denotes Epstein-Barr virus
T6274 894-897 NCBITaxon:10376 denotes EBV
T6275 912-923 CL:0000542 denotes lymphocytes
T6276 1038-1043 PR_EXT:000009158 denotes ITPR1
T6277 1100-1108 SO_EXT:sequence_deletion_entity_or_process denotes deletion

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5948 57-62 PR:000015827 denotes SUMF1
T5949 73-101 PR:000015827 denotes sulfatase modifying factor 1
T5950 168-173 PR:000015827 denotes SUMF1
T5951 185-194 GO:0030849 denotes autosomal
T5952 238-247 GO:0008152 denotes metabolic
T5953 479-484 PR:000009158 denotes ITPR1
T5954 555-564 GO:0010467 denotes expressed
T5955 568-582 CL:0000121 denotes Purkinje cells
T5956 607-611 NCBITaxon:10088 denotes mice
T5957 675-679 CHEBI:29108 denotes Ca2+
T5958 675-689 GO:0019722 denotes Ca2+ signaling
T5959 865-870 PR:000009158 denotes ITPR1
T5960 874-892 NCBITaxon:10376 denotes Epstein-Barr virus
T5961 894-897 NCBITaxon:10376 denotes EBV
T5962 912-923 CL:0000542 denotes lymphocytes
T5963 1038-1043 PR:000009158 denotes ITPR1

craft-sa-dev

Id Subject Object Predicate Lexical cue
T7923 0-2 PRP denotes It
T7924 3-5 VBZ denotes is
T7925 6-16 JJ denotes improbable
T7926 17-21 IN denotes that
T7927 113-119 VBZ denotes causes
T7928 22-36 NN denotes heterozygosity
T7929 37-40 IN denotes for
T7930 41-44 DT denotes the
T7931 45-53 NN denotes deletion
T7932 54-56 IN denotes of
T7933 57-62 NN denotes SUMF1
T7934 62-64 , denotes ,
T7935 64-72 VBG denotes encoding
T7936 73-82 NN denotes sulfatase
T7937 93-99 NN denotes factor
T7938 83-92 VBG denotes modifying
T7939 100-101 CD denotes 1
T7940 101-103 , denotes ,
T7941 103-105 IN denotes of
T7942 106-112 PRP denotes itself
T7943 120-122 CC denotes or
T7944 123-134 VBZ denotes contributes
T7945 135-137 IN denotes to
T7946 138-143 NN denotes SCA15
T7947 143-144 . denotes .
T7948 144-334 sentence denotes Homozygous mutation of SUMF1 results in autosomal recessive multiple sulfatase deficiency, a metabolic disorder characterized by hepatosplenomegaly, deafness, and developmental delay [6,7].
T7949 145-155 JJ denotes Homozygous
T7950 156-164 NN denotes mutation
T7951 174-181 VBZ denotes results
T7952 165-167 IN denotes of
T7953 168-173 NN denotes SUMF1
T7954 182-184 IN denotes in
T7955 185-194 JJ denotes autosomal
T7956 224-234 NN denotes deficiency
T7957 195-204 JJ denotes recessive
T7958 205-213 JJ denotes multiple
T7959 214-223 NN denotes sulfatase
T7960 234-236 , denotes ,
T7961 236-237 DT denotes a
T7962 248-256 NN denotes disorder
T7963 238-247 JJ denotes metabolic
T7964 257-270 VBN denotes characterized
T7965 271-273 IN denotes by
T7966 274-292 NN denotes hepatosplenomegaly
T7967 292-294 , denotes ,
T7968 294-302 NN denotes deafness
T7969 302-304 , denotes ,
T7970 304-307 CC denotes and
T7971 308-321 JJ denotes developmental
T7972 322-327 NN denotes delay
T7973 328-329 -LRB- denotes [
T7974 331-332 CD denotes 7
T7975 329-330 CD denotes 6
T7976 330-331 , denotes ,
T7977 332-333 -RRB- denotes ]
T7978 333-334 . denotes .
T7979 334-454 sentence denotes No co-occurrence of ataxia has been described in (heterozygous) parents of patients with multiple sulfatase deficiency.
T7980 335-337 DT denotes No
T7981 338-351 NN denotes co-occurrence
T7982 371-380 VBN denotes described
T7983 352-354 IN denotes of
T7984 355-361 NN denotes ataxia
T7985 362-365 VBZ denotes has
T7986 366-370 VBN denotes been
T7987 381-383 IN denotes in
T7988 384-385 -LRB- denotes (
T7989 399-406 NNS denotes parents
T7990 385-397 JJ denotes heterozygous
T7991 397-398 -RRB- denotes )
T7992 407-409 IN denotes of
T7993 410-418 NNS denotes patients
T7994 419-423 IN denotes with
T7995 424-432 JJ denotes multiple
T7996 443-453 NN denotes deficiency
T7997 433-442 NN denotes sulfatase
T7998 453-454 . denotes .
T7999 454-795 sentence denotes Conversely, mutation of ITPR1 is biologically plausible as a cause of ataxia: the protein is highly expressed in Purkinje cells; as we have shown here, mice with mutation at this locus present with ataxia; and perturbed Ca2+ signaling has previously been implicated in the etiology of ataxia, notably in episodic ataxia type 2 and SCA6 [8].
T8000 455-465 RB denotes Conversely
T8001 640-647 VBP denotes present
T8002 465-467 , denotes ,
T8003 467-475 NN denotes mutation
T8004 485-487 VBZ denotes is
T8005 476-478 IN denotes of
T8006 479-484 NN denotes ITPR1
T8007 488-500 RB denotes biologically
T8008 501-510 JJ denotes plausible
T8009 511-513 IN denotes as
T8010 514-515 DT denotes a
T8011 516-521 NN denotes cause
T8012 522-524 IN denotes of
T8013 525-531 NN denotes ataxia
T8014 531-533 : denotes :
T8015 533-536 DT denotes the
T8016 537-544 NN denotes protein
T8017 555-564 VBN denotes expressed
T8018 545-547 VBZ denotes is
T8019 548-554 RB denotes highly
T8020 565-567 IN denotes in
T8021 568-576 NNP denotes Purkinje
T8022 577-582 NNS denotes cells
T8023 582-583 : denotes ;
T8024 584-586 IN denotes as
T8025 595-600 VBN denotes shown
T8026 587-589 PRP denotes we
T8027 590-594 VBP denotes have
T8028 601-605 RB denotes here
T8029 605-607 , denotes ,
T8030 607-611 NNS denotes mice
T8031 612-616 IN denotes with
T8032 617-625 NN denotes mutation
T8033 626-628 IN denotes at
T8034 629-633 DT denotes this
T8035 634-639 NN denotes locus
T8036 648-652 IN denotes with
T8037 653-659 NN denotes ataxia
T8038 659-660 : denotes ;
T8039 661-664 CC denotes and
T8040 665-674 VBN denotes perturbed
T8041 680-689 NN denotes signaling
T8042 675-679 NN denotes Ca2+
T8043 710-720 VBN denotes implicated
T8044 690-693 VBZ denotes has
T8045 694-704 RB denotes previously
T8046 705-709 VBN denotes been
T8047 721-723 IN denotes in
T8048 724-727 DT denotes the
T8049 728-736 NN denotes etiology
T8050 737-739 IN denotes of
T8051 740-746 NN denotes ataxia
T8052 746-748 , denotes ,
T8053 748-755 RB denotes notably
T8054 756-758 IN denotes in
T8055 759-767 JJ denotes episodic
T8056 775-779 NN denotes type
T8057 768-774 NN denotes ataxia
T8058 780-781 CD denotes 2
T8059 782-785 CC denotes and
T8060 786-790 NN denotes SCA6
T8061 791-792 -LRB- denotes [
T8062 792-793 CD denotes 8
T8063 793-794 -RRB- denotes ]
T8064 794-795 . denotes .
T8065 795-1120 sentence denotes In further support of this conclusion, analysis of protein levels of ITPR1 in Epstein-Barr virus (EBV) immortalized lymphocytes from affected and unaffected AUS1 family members revealed that all affected members showed a dramatic decrease in ITPR1 levels when compared with the family member without the deletion (Figure 4).
T8066 796-798 IN denotes In
T8067 973-981 VBD denotes revealed
T8068 799-806 JJ denotes further
T8069 807-814 NN denotes support
T8070 815-817 IN denotes of
T8071 818-822 DT denotes this
T8072 823-833 NN denotes conclusion
T8073 833-835 , denotes ,
T8074 835-843 NN denotes analysis
T8075 844-846 IN denotes of
T8076 847-854 NN denotes protein
T8077 855-861 NNS denotes levels
T8078 862-864 IN denotes of
T8079 865-870 NN denotes ITPR1
T8080 871-873 IN denotes in
T8081 874-881 NN denotes Epstein
T8082 882-886 NN denotes Barr
T8083 881-882 HYPH denotes -
T8084 887-892 NN denotes virus
T8085 912-923 NNS denotes lymphocytes
T8086 893-894 -LRB- denotes (
T8087 894-897 NN denotes EBV
T8088 897-898 -RRB- denotes )
T8089 899-911 VBN denotes immortalized
T8090 924-928 IN denotes from
T8091 929-937 VBN denotes affected
T8092 965-972 NNS denotes members
T8093 938-941 CC denotes and
T8094 942-952 JJ denotes unaffected
T8095 953-957 NN denotes AUS1
T8096 958-964 NN denotes family
T8097 982-986 IN denotes that
T8098 1008-1014 VBD denotes showed
T8099 987-990 DT denotes all
T8100 1000-1007 NNS denotes members
T8101 991-999 VBN denotes affected
T8102 1015-1016 DT denotes a
T8103 1026-1034 NN denotes decrease
T8104 1017-1025 JJ denotes dramatic
T8105 1035-1037 IN denotes in
T8106 1038-1043 NN denotes ITPR1
T8107 1044-1050 NNS denotes levels
T8108 1051-1055 WRB denotes when
T8109 1056-1064 VBN denotes compared
T8110 1065-1069 IN denotes with
T8111 1070-1073 DT denotes the
T8112 1081-1087 NN denotes member
T8113 1074-1080 NN denotes family
T8114 1088-1095 IN denotes without
T8115 1096-1099 DT denotes the
T8116 1100-1108 NN denotes deletion
T8117 1109-1110 -LRB- denotes (
T8118 1110-1116 NN denotes Figure
T8119 1117-1118 CD denotes 4
T8120 1118-1119 -RRB- denotes )
T8121 1119-1120 . denotes .
R1821 T7959 T7956 compound sulfatase,deficiency
R1827 T7960 T7956 punct ", ",deficiency
R1831 T7961 T7962 det a,disorder
R1833 T7962 T7956 appos disorder,deficiency
R1837 T7963 T7962 amod metabolic,disorder
R1838 T7964 T7962 acl characterized,disorder
R1840 T7965 T7964 agent by,characterized
R1843 T7966 T7965 pobj hepatosplenomegaly,by
R1846 T7967 T7966 punct ", ",hepatosplenomegaly
R1850 T7968 T7966 conj deafness,hepatosplenomegaly
R1857 T7969 T7968 punct ", ",deafness
R1861 T7970 T7968 cc and,deafness
R1865 T7971 T7972 amod developmental,delay
R1869 T7972 T7968 conj delay,deafness
R1872 T7973 T7974 punct [,7
R1876 T7974 T7951 parataxis 7,results
R1880 T7975 T7974 nummod 6,7
R1883 T7976 T7974 punct ",",7
R1887 T7977 T7974 punct ],7
R1891 T7978 T7951 punct .,results
R1895 T7980 T7981 det No,co-occurrence
R1900 T7981 T7982 nsubjpass co-occurrence,described
R1903 T7983 T7981 prep of,co-occurrence
R1904 T7923 T7924 nsubj It,is
R1905 T7925 T7924 acomp improbable,is
R1906 T7926 T7927 mark that,causes
R1907 T7927 T7924 ccomp causes,is
R1908 T7928 T7927 nsubj heterozygosity,causes
R1909 T7984 T7983 pobj ataxia,of
R1910 T7929 T7928 prep for,heterozygosity
R1911 T7930 T7931 det the,deletion
R1912 T7985 T7982 aux has,described
R1913 T7931 T7929 pobj deletion,for
R1914 T7932 T7931 prep of,deletion
R1915 T7933 T7932 pobj SUMF1,of
R1916 T7934 T7928 punct ", ",heterozygosity
R1917 T7986 T7982 auxpass been,described
R1918 T7935 T7928 acl encoding,heterozygosity
R1919 T7936 T7937 nmod sulfatase,factor
R1920 T7987 T7982 prep in,described
R1921 T7937 T7935 dobj factor,encoding
R1922 T7938 T7937 amod modifying,factor
R1923 T7939 T7937 nummod 1,factor
R1924 T7988 T7989 punct (,parents
R1925 T7940 T7928 punct ", ",heterozygosity
R1926 T7941 T7928 prep of,heterozygosity
R1927 T7942 T7941 pobj itself,of
R1928 T7989 T7987 pobj parents,in
R1929 T7943 T7927 cc or,causes
R1930 T7944 T7927 conj contributes,causes
R1931 T7990 T7989 amod heterozygous,parents
R1932 T7945 T7944 prep to,contributes
R1933 T7946 T7944 dobj SCA15,contributes
R1934 T7947 T7924 punct .,is
R1935 T7991 T7989 punct ),parents
R1936 T7949 T7950 amod Homozygous,mutation
R1937 T7950 T7951 nsubj mutation,results
R1938 T7992 T7989 prep of,parents
R1939 T7952 T7950 prep of,mutation
R1940 T7993 T7992 pobj patients,of
R1941 T7953 T7952 pobj SUMF1,of
R1942 T7954 T7951 prep in,results
R1943 T7955 T7956 amod autosomal,deficiency
R1944 T7994 T7993 prep with,patients
R1945 T7995 T7996 amod multiple,deficiency
R1946 T7956 T7954 pobj deficiency,in
R1947 T7957 T7956 amod recessive,deficiency
R1948 T7996 T7994 pobj deficiency,with
R1949 T7958 T7956 amod multiple,deficiency
R1950 T7997 T7996 compound sulfatase,deficiency
R1951 T7998 T7982 punct .,described
R1952 T8000 T8001 advmod Conversely,present
R1953 T8066 T8067 prep In,revealed
R1954 T8002 T8001 punct ", ",present
R1955 T8068 T8069 amod further,support
R1956 T8069 T8066 pobj support,In
R1957 T8003 T8004 nsubj mutation,is
R1958 T8070 T8069 prep of,support
R1959 T8071 T8072 det this,conclusion
R1960 T8072 T8070 pobj conclusion,of
R1961 T8073 T8067 punct ", ",revealed
R1962 T8074 T8067 nsubj analysis,revealed
R1963 T8004 T8001 ccomp is,present
R1964 T8075 T8074 prep of,analysis
R1965 T8076 T8077 compound protein,levels
R1966 T8077 T8075 pobj levels,of
R1967 T8005 T8003 prep of,mutation
R1968 T8078 T8077 prep of,levels
R1969 T8079 T8078 pobj ITPR1,of
R1970 T8080 T8079 prep in,ITPR1
R1971 T8006 T8005 pobj ITPR1,of
R1972 T8081 T8082 nmod Epstein,Barr
R1973 T8082 T8084 nmod Barr,virus
R1974 T8007 T8008 advmod biologically,plausible
R1975 T8083 T8082 punct -,Barr
R1976 T8084 T8085 nmod virus,lymphocytes
R1977 T8085 T8080 pobj lymphocytes,in
R1978 T8008 T8004 acomp plausible,is
R1979 T8086 T8084 punct (,virus
R1980 T8087 T8084 appos EBV,virus
R1981 T8088 T8085 punct ),lymphocytes
R1982 T8009 T8004 prep as,is
R1983 T8089 T8085 amod immortalized,lymphocytes
R1984 T8090 T8085 prep from,lymphocytes
R1985 T8091 T8092 amod affected,members
R1986 T8010 T8011 det a,cause
R1987 T8092 T8090 pobj members,from
R1988 T8011 T8009 pobj cause,as
R1989 T8012 T8011 prep of,cause
R1990 T8093 T8091 cc and,affected
R1991 T8013 T8012 pobj ataxia,of
R1992 T8094 T8091 conj unaffected,affected
R1993 T8095 T8092 compound AUS1,members
R1994 T8096 T8092 compound family,members
R1995 T8014 T8001 punct : ,present
R1996 T8097 T8098 mark that,showed
R1997 T8098 T8067 ccomp showed,revealed
R1998 T8099 T8100 det all,members
R1999 T8015 T8016 det the,protein
R2000 T8100 T8098 nsubj members,showed
R2001 T8101 T8100 amod affected,members
R2002 T8102 T8103 det a,decrease
R2003 T8016 T8017 nsubjpass protein,expressed
R2004 T8103 T8098 dobj decrease,showed
R2005 T8104 T8103 amod dramatic,decrease
R2006 T8105 T8103 prep in,decrease
R2007 T8017 T8001 ccomp expressed,present
R2008 T8106 T8107 compound ITPR1,levels
R2009 T8107 T8105 pobj levels,in
R2010 T8108 T8109 advmod when,compared
R2011 T8109 T8098 advcl compared,showed
R2012 T8110 T8109 prep with,compared
R2013 T8018 T8017 auxpass is,expressed
R2014 T8111 T8112 det the,member
R2015 T8112 T8110 pobj member,with
R2016 T8113 T8112 compound family,member
R2017 T8114 T8112 prep without,member
R2018 T8019 T8017 advmod highly,expressed
R2019 T8115 T8116 det the,deletion
R2020 T8116 T8114 pobj deletion,without
R2021 T8020 T8017 prep in,expressed
R2022 T8117 T8118 punct (,Figure
R2023 T8118 T8067 parataxis Figure,revealed
R2024 T8119 T8118 nummod 4,Figure
R2025 T8021 T8022 compound Purkinje,cells
R2026 T8120 T8118 punct ),Figure
R2027 T8121 T8067 punct .,revealed
R2028 T8022 T8020 pobj cells,in
R2031 T8023 T8001 punct ;,present
R2034 T8024 T8025 mark as,shown
R2036 T8025 T8001 advcl shown,present
R2038 T8026 T8025 nsubj we,shown
R2042 T8027 T8025 aux have,shown
R2046 T8028 T8025 advmod here,shown
R2049 T8029 T8001 punct ", ",present
R2053 T8030 T8001 nsubj mice,present
R2056 T8031 T8030 prep with,mice
R2060 T8032 T8031 pobj mutation,with
R2066 T8033 T8032 prep at,mutation
R2070 T8034 T8035 det this,locus
R2074 T8035 T8033 pobj locus,at
R2078 T8036 T8001 prep with,present
R2082 T8037 T8036 pobj ataxia,with
R2085 T8038 T8001 punct ;,present
R2087 T8039 T8001 cc and,present
R2090 T8040 T8041 amod perturbed,signaling
R2092 T8041 T8043 nsubjpass signaling,implicated
R2093 T8042 T8041 compound Ca2+,signaling
R2096 T8043 T8001 conj implicated,present
R2101 T8044 T8043 aux has,implicated
R2104 T8045 T8043 advmod previously,implicated
R2108 T8046 T8043 auxpass been,implicated
R2112 T8047 T8043 prep in,implicated
R2119 T8048 T8049 det the,etiology
R2123 T8049 T8047 pobj etiology,in
R2127 T8050 T8049 prep of,etiology
R2130 T8051 T8050 pobj ataxia,of
R2132 T8052 T8043 punct ", ",implicated
R2136 T8053 T8054 advmod notably,in
R2140 T8054 T8043 prep in,implicated
R2144 T8055 T8056 amod episodic,type
R2148 T8056 T8054 pobj type,in
R2149 T8057 T8056 compound ataxia,type
R2151 T8058 T8056 nummod 2,type
R2153 T8059 T8056 cc and,type
R2158 T8060 T8056 conj SCA6,type
R2162 T8061 T8062 punct [,8
R2164 T8062 T8043 parataxis 8,implicated
R2169 T8063 T8062 punct ],8
R2174 T8064 T8001 punct .,present

2_test

Id Subject Object Predicate Lexical cue
17590087-12757706-85657852 329-330 12757706 denotes 6
17590087-15146462-85657853 331-332 15146462 denotes 7
17590087-8988170-85657854 792-793 8988170 denotes 8
T64473 329-330 12757706 denotes 6
T55562 331-332 15146462 denotes 7
T45916 792-793 8988170 denotes 8