PMC:1867812 / 49424-50280 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1867812","sourcedb":"PMC","sourceid":"1867812","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1867812","text":"In this article, we present a novel approach to analyze protein folding trajectories and a case study on the small proteins BBA5 and GSGS. We capture a variety of structural motifs in the 3D protein conformations by non-local bit-patterns identified in their 2D contact maps. By modeling the interactions or spatial relationships among bit-patterns as SOAPs and SOAP episodes, we effectively characterize the evolutionary nature of the folding process. We also describe two methods to summarize folding trajectories by super-imposing protein specific information and 3D motifs onto SOAPs. Utilizing the summarized trajectories, we demonstrate that one can detect folding events and the temporal order among events. We also show that through comparing such summarized trajectories, one can identify a partial folding pathway common to multiple trajectories.","tracks":[]}