PMC:1867812 / 41366-42289 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1867812","sourcedb":"PMC","sourceid":"1867812","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1867812","text":"To do this, we simply compute the longest common sub-sequence (LCS) [17] between two summarized trajectories. One can utilize the summarization either before the 3D motif generalization (Figure 9(a)) or after (Figure 9(b)). We use the latter in our analysis. Based on the LCS of generalized SOAPs, we construct the consensus folding pathway by identifying pairs of conformations, one from each trajectory, along the LCS of two summarized trajectories. In other words, the resulting consensus pathway consists of a sequence of conformation-pairs of similar 3D structures. Notice here that the comparison between 3D protein conformations (as described in Section 2.2) is done by using bit-patterns to model local structural motifs, and associations of bit-patterns (SOAPs) to characterize the global structure. This forms a hierarchical comparison and is in accordance with the hierarchical folding process of small proteins.","tracks":[]}