PMC:1867812 / 2043-2867 JSONTXT

{"project":"2_test","denotations":[{"id":"17407611-12422224-1692912","span":{"begin":679,"end":680},"obj":"12422224"}],"text":"The three dimensional (3D) native structures of proteins have important implications in proteomics. Understanding such structures enables us to explore the function of a protein, explain substrate and ligand binding, perform realistic drug design and potentially cure diseases caused by protein misfolding. The protein folding problem is therefore one of the most fundamental yet unsolved problems in computational molecular biology. One major challenge in simulating the protein folding process is its complexity. Snow et al. state that performing a Molecular Dynamics (MD) simulation on a mini-protein for just 10 μs would require decades of computation time on a typical CPU [1]. Researchers in the Folding@home project recently proposed a World Wide Web-based computing model to simulate the protein folding process [2]."}