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Supplementary Material Additional file 1 Summary information on the 509 genes differentially expressed between DBA/1 and FVB/N strains. Comparison was performed between two strains at four stages of CIA, NA, PI, OA and CA. Three criteria were applied for selecting the differentially expressed genes: the lower 90% confidence bound of fold change between the group means exceeded twofold; the absolute difference between the two groups exceeded 100; the P value threshold of the unpaired t-test was 0.05 Click here for file Additional file 2 Summary information on the 311 genes differentially expressed in joints in the DBA/1 strain during CIA. Pairwise comparisons were performed by comparing PI, OA and CA with NA. Three criteria were applied for selecting the differentially expressed genes: the lower 90% confidence bound of fold change between the group means exceeded twofold; the absolute difference between the two groups exceeded 100; the P value threshold of the unpaired t-test was 0.05 Click here for file Additional file 3 Summary information on the 117 genes that were strain-specific differentially expressed and were dysregulated in the DBA/1 strain during CIA. The physical positions of the genes were retrieved from Ensembl [30] Click here for file