Id |
Subject |
Object |
Predicate |
Lexical cue |
T14922 |
0-2 |
PRP |
denotes |
We |
T14923 |
3-10 |
VBP |
denotes |
present |
T14924 |
11-12 |
DT |
denotes |
a |
T14925 |
13-21 |
NN |
denotes |
strategy |
T14926 |
22-24 |
TO |
denotes |
to |
T14927 |
25-31 |
VB |
denotes |
search |
T14928 |
32-41 |
NN |
denotes |
candidate |
T14929 |
42-47 |
NNS |
denotes |
genes |
T14930 |
48-51 |
IN |
denotes |
for |
T14931 |
52-57 |
JJ |
denotes |
small |
T14932 |
58-64 |
NN |
denotes |
effect |
T14933 |
57-58 |
HYPH |
denotes |
- |
T14934 |
65-68 |
NNS |
denotes |
QTL |
T14935 |
68-69 |
. |
denotes |
. |
T14936 |
69-176 |
sentence |
denotes |
With this strategy, we identified 21 candidate genes for 8 small-effect QTL regulating CIA susceptibility. |
T14937 |
70-74 |
IN |
denotes |
With |
T14938 |
93-103 |
VBD |
denotes |
identified |
T14939 |
75-79 |
DT |
denotes |
this |
T14940 |
80-88 |
NN |
denotes |
strategy |
T14941 |
88-90 |
, |
denotes |
, |
T14942 |
90-92 |
PRP |
denotes |
we |
T14943 |
104-106 |
CD |
denotes |
21 |
T14944 |
117-122 |
NNS |
denotes |
genes |
T14945 |
107-116 |
NN |
denotes |
candidate |
T14946 |
123-126 |
IN |
denotes |
for |
T14947 |
127-128 |
CD |
denotes |
8 |
T14948 |
161-175 |
NN |
denotes |
susceptibility |
T14949 |
129-134 |
JJ |
denotes |
small |
T14950 |
135-141 |
NN |
denotes |
effect |
T14951 |
134-135 |
HYPH |
denotes |
- |
T14952 |
142-145 |
NNS |
denotes |
QTL |
T14953 |
146-156 |
VBG |
denotes |
regulating |
T14954 |
157-160 |
NN |
denotes |
CIA |
T14955 |
175-176 |
. |
denotes |
. |
T14956 |
176-237 |
sentence |
denotes |
Our future studies will be carried out using two approaches. |
T14957 |
177-180 |
PRP$ |
denotes |
Our |
T14958 |
188-195 |
NNS |
denotes |
studies |
T14959 |
181-187 |
JJ |
denotes |
future |
T14960 |
204-211 |
VBN |
denotes |
carried |
T14961 |
196-200 |
MD |
denotes |
will |
T14962 |
201-203 |
VB |
denotes |
be |
T14963 |
212-215 |
RP |
denotes |
out |
T14964 |
216-221 |
VBG |
denotes |
using |
T14965 |
222-225 |
CD |
denotes |
two |
T14966 |
226-236 |
NNS |
denotes |
approaches |
T14967 |
236-237 |
. |
denotes |
. |
T14968 |
237-398 |
sentence |
denotes |
The first is generating congenic animals for promising small-effect QTL that have relatively high P values and overlap with previously-identified arthritis QTL. |
T14969 |
238-241 |
DT |
denotes |
The |
T14970 |
242-247 |
JJ |
denotes |
first |
T14971 |
251-261 |
VBG |
denotes |
generating |
T14972 |
248-250 |
VBZ |
denotes |
is |
T14973 |
262-270 |
JJ |
denotes |
congenic |
T14974 |
271-278 |
NNS |
denotes |
animals |
T14975 |
279-282 |
IN |
denotes |
for |
T14976 |
283-292 |
VBG |
denotes |
promising |
T14977 |
306-309 |
NNS |
denotes |
QTL |
T14978 |
293-298 |
JJ |
denotes |
small |
T14979 |
299-305 |
NN |
denotes |
effect |
T14980 |
298-299 |
HYPH |
denotes |
- |
T14981 |
310-314 |
WDT |
denotes |
that |
T14982 |
315-319 |
VBP |
denotes |
have |
T14983 |
320-330 |
RB |
denotes |
relatively |
T14984 |
331-335 |
JJ |
denotes |
high |
T14985 |
338-344 |
NNS |
denotes |
values |
T14986 |
336-337 |
NN |
denotes |
P |
T14987 |
345-348 |
CC |
denotes |
and |
T14988 |
349-356 |
VBP |
denotes |
overlap |
T14989 |
357-361 |
IN |
denotes |
with |
T14990 |
362-372 |
RB |
denotes |
previously |
T14991 |
373-383 |
VBN |
denotes |
identified |
T14992 |
372-373 |
HYPH |
denotes |
- |
T14993 |
394-397 |
NNS |
denotes |
QTL |
T14994 |
384-393 |
NN |
denotes |
arthritis |
T14995 |
397-398 |
. |
denotes |
. |
T14996 |
398-487 |
sentence |
denotes |
The second approach is investigating candidate genes using both mouse and human studies. |
T14997 |
399-402 |
DT |
denotes |
The |
T14998 |
410-418 |
NN |
denotes |
approach |
T14999 |
403-409 |
JJ |
denotes |
second |
T15000 |
419-421 |
VBZ |
denotes |
is |
T15001 |
422-435 |
VBG |
denotes |
investigating |
T15002 |
436-445 |
NN |
denotes |
candidate |
T15003 |
446-451 |
NNS |
denotes |
genes |
T15004 |
452-457 |
VBG |
denotes |
using |
T15005 |
458-462 |
CC |
denotes |
both |
T15006 |
463-468 |
NN |
denotes |
mouse |
T15007 |
479-486 |
NNS |
denotes |
studies |
T15008 |
469-472 |
CC |
denotes |
and |
T15009 |
473-478 |
JJ |
denotes |
human |
T15010 |
486-487 |
. |
denotes |
. |
T15011 |
487-590 |
sentence |
denotes |
Candidate genes will be selected according to their function and polymorphism between the two strains. |
T15012 |
488-497 |
NN |
denotes |
Candidate |
T15013 |
498-503 |
NNS |
denotes |
genes |
T15014 |
512-520 |
VBN |
denotes |
selected |
T15015 |
504-508 |
MD |
denotes |
will |
T15016 |
509-511 |
VB |
denotes |
be |
T15017 |
521-530 |
VBG |
denotes |
according |
T15018 |
531-533 |
IN |
denotes |
to |
T15019 |
534-539 |
PRP$ |
denotes |
their |
T15020 |
540-548 |
NN |
denotes |
function |
T15021 |
549-552 |
CC |
denotes |
and |
T15022 |
553-565 |
NN |
denotes |
polymorphism |
T15023 |
566-573 |
IN |
denotes |
between |
T15024 |
574-577 |
DT |
denotes |
the |
T15025 |
582-589 |
NNS |
denotes |
strains |
T15026 |
578-581 |
CD |
denotes |
two |
T15027 |
589-590 |
. |
denotes |
. |
T15028 |
590-679 |
sentence |
denotes |
Thereafter, we will generate knock-out mice to investigate the role of the genes in CIA. |
T15029 |
591-601 |
RB |
denotes |
Thereafter |
T15030 |
611-619 |
VB |
denotes |
generate |
T15031 |
601-603 |
, |
denotes |
, |
T15032 |
603-605 |
PRP |
denotes |
we |
T15033 |
606-610 |
MD |
denotes |
will |
T15034 |
620-625 |
VB |
denotes |
knock |
T15035 |
630-634 |
NNS |
denotes |
mice |
T15036 |
625-626 |
HYPH |
denotes |
- |
T15037 |
626-629 |
RP |
denotes |
out |
T15038 |
635-637 |
TO |
denotes |
to |
T15039 |
638-649 |
VB |
denotes |
investigate |
T15040 |
650-653 |
DT |
denotes |
the |
T15041 |
654-658 |
NN |
denotes |
role |
T15042 |
659-661 |
IN |
denotes |
of |
T15043 |
662-665 |
DT |
denotes |
the |
T15044 |
666-671 |
NNS |
denotes |
genes |
T15045 |
672-674 |
IN |
denotes |
in |
T15046 |
675-678 |
NN |
denotes |
CIA |
T15047 |
678-679 |
. |
denotes |
. |
T15048 |
679-843 |
sentence |
denotes |
For the loci whose counterparts on the human genome are linked to RA, we will investigate the candidate genes using case-control association studies in RA cohorts. |
T15049 |
680-683 |
IN |
denotes |
For |
T15050 |
758-769 |
VB |
denotes |
investigate |
T15051 |
684-687 |
DT |
denotes |
the |
T15052 |
688-692 |
NNS |
denotes |
loci |
T15053 |
693-698 |
WP$ |
denotes |
whose |
T15054 |
699-711 |
NNS |
denotes |
counterparts |
T15055 |
736-742 |
VBN |
denotes |
linked |
T15056 |
712-714 |
IN |
denotes |
on |
T15057 |
715-718 |
DT |
denotes |
the |
T15058 |
725-731 |
NN |
denotes |
genome |
T15059 |
719-724 |
JJ |
denotes |
human |
T15060 |
732-735 |
VBP |
denotes |
are |
T15061 |
743-745 |
IN |
denotes |
to |
T15062 |
746-748 |
NN |
denotes |
RA |
T15063 |
748-750 |
, |
denotes |
, |
T15064 |
750-752 |
PRP |
denotes |
we |
T15065 |
753-757 |
MD |
denotes |
will |
T15066 |
770-773 |
DT |
denotes |
the |
T15067 |
784-789 |
NNS |
denotes |
genes |
T15068 |
774-783 |
NN |
denotes |
candidate |
T15069 |
790-795 |
VBG |
denotes |
using |
T15070 |
796-800 |
NN |
denotes |
case |
T15071 |
801-808 |
NN |
denotes |
control |
T15072 |
800-801 |
HYPH |
denotes |
- |
T15073 |
821-828 |
NNS |
denotes |
studies |
T15074 |
809-820 |
NN |
denotes |
association |
T15075 |
829-831 |
IN |
denotes |
in |
T15076 |
832-834 |
NN |
denotes |
RA |
T15077 |
835-842 |
NNS |
denotes |
cohorts |
T15078 |
842-843 |
. |
denotes |
. |
R4570 |
T14922 |
T14923 |
nsubj |
We,present |
R4571 |
T14924 |
T14925 |
det |
a,strategy |
R4572 |
T14925 |
T14923 |
dobj |
strategy,present |
R4573 |
T14926 |
T14927 |
aux |
to,search |
R4574 |
T14927 |
T14925 |
advcl |
search,strategy |
R4575 |
T14928 |
T14929 |
compound |
candidate,genes |
R4576 |
T14929 |
T14927 |
dobj |
genes,search |
R4577 |
T14930 |
T14927 |
prep |
for,search |
R4578 |
T14931 |
T14932 |
amod |
small,effect |
R4579 |
T14932 |
T14934 |
compound |
effect,QTL |
R4580 |
T14933 |
T14932 |
punct |
-,effect |
R4581 |
T14934 |
T14930 |
pobj |
QTL,for |
R4582 |
T14935 |
T14923 |
punct |
.,present |
R4583 |
T14937 |
T14938 |
prep |
With,identified |
R4584 |
T14939 |
T14940 |
det |
this,strategy |
R4585 |
T14940 |
T14937 |
pobj |
strategy,With |
R4586 |
T14941 |
T14938 |
punct |
", ",identified |
R4587 |
T14942 |
T14938 |
nsubj |
we,identified |
R4588 |
T14943 |
T14944 |
nummod |
21,genes |
R4589 |
T14944 |
T14938 |
dobj |
genes,identified |
R4590 |
T14945 |
T14944 |
compound |
candidate,genes |
R4591 |
T14946 |
T14944 |
prep |
for,genes |
R4592 |
T14947 |
T14948 |
nummod |
8,susceptibility |
R4593 |
T14948 |
T14946 |
pobj |
susceptibility,for |
R4594 |
T14949 |
T14950 |
amod |
small,effect |
R4595 |
T14950 |
T14948 |
nmod |
effect,susceptibility |
R4596 |
T14951 |
T14950 |
punct |
-,effect |
R4597 |
T14952 |
T14953 |
npadvmod |
QTL,regulating |
R4598 |
T14953 |
T14948 |
amod |
regulating,susceptibility |
R4599 |
T14954 |
T14948 |
compound |
CIA,susceptibility |
R4600 |
T14955 |
T14938 |
punct |
.,identified |
R4601 |
T14957 |
T14958 |
poss |
Our,studies |
R4602 |
T14958 |
T14960 |
nsubjpass |
studies,carried |
R4603 |
T14959 |
T14958 |
amod |
future,studies |
R4604 |
T14961 |
T14960 |
aux |
will,carried |
R4605 |
T14962 |
T14960 |
auxpass |
be,carried |
R4606 |
T14963 |
T14960 |
prt |
out,carried |
R4607 |
T14964 |
T14960 |
advcl |
using,carried |
R4608 |
T14965 |
T14966 |
nummod |
two,approaches |
R4609 |
T14966 |
T14964 |
dobj |
approaches,using |
R4610 |
T14967 |
T14960 |
punct |
.,carried |
R4611 |
T14969 |
T14970 |
det |
The,first |
R4612 |
T14970 |
T14971 |
nsubj |
first,generating |
R4613 |
T14972 |
T14971 |
aux |
is,generating |
R4614 |
T14973 |
T14974 |
amod |
congenic,animals |
R4615 |
T14974 |
T14971 |
dobj |
animals,generating |
R4616 |
T14975 |
T14971 |
prep |
for,generating |
R4617 |
T14976 |
T14977 |
amod |
promising,QTL |
R4618 |
T14977 |
T14975 |
pobj |
QTL,for |
R4619 |
T14978 |
T14979 |
amod |
small,effect |
R4620 |
T14979 |
T14977 |
compound |
effect,QTL |
R4621 |
T14980 |
T14979 |
punct |
-,effect |
R4622 |
T14981 |
T14982 |
dep |
that,have |
R4623 |
T14982 |
T14977 |
relcl |
have,QTL |
R4624 |
T14983 |
T14984 |
advmod |
relatively,high |
R4625 |
T14984 |
T14985 |
amod |
high,values |
R4626 |
T14985 |
T14982 |
dobj |
values,have |
R4627 |
T14986 |
T14985 |
compound |
P,values |
R4628 |
T14987 |
T14982 |
cc |
and,have |
R4629 |
T14988 |
T14982 |
conj |
overlap,have |
R4630 |
T14989 |
T14988 |
prep |
with,overlap |
R4631 |
T14990 |
T14991 |
advmod |
previously,identified |
R4632 |
T14991 |
T14993 |
amod |
identified,QTL |
R4633 |
T14992 |
T14991 |
punct |
-,identified |
R4634 |
T14993 |
T14989 |
pobj |
QTL,with |
R4635 |
T14994 |
T14993 |
compound |
arthritis,QTL |
R4636 |
T14995 |
T14971 |
punct |
.,generating |
R4637 |
T14997 |
T14998 |
det |
The,approach |
R4638 |
T14998 |
T15000 |
nsubj |
approach,is |
R4639 |
T14999 |
T14998 |
amod |
second,approach |
R4640 |
T15001 |
T15000 |
xcomp |
investigating,is |
R4641 |
T15002 |
T15003 |
compound |
candidate,genes |
R4642 |
T15003 |
T15001 |
dobj |
genes,investigating |
R4643 |
T15004 |
T15001 |
advcl |
using,investigating |
R4644 |
T15005 |
T15006 |
preconj |
both,mouse |
R4645 |
T15006 |
T15007 |
nmod |
mouse,studies |
R4646 |
T15007 |
T15004 |
dobj |
studies,using |
R4647 |
T15008 |
T15006 |
cc |
and,mouse |
R4648 |
T15009 |
T15006 |
conj |
human,mouse |
R4649 |
T15010 |
T15000 |
punct |
.,is |
R4650 |
T15012 |
T15013 |
compound |
Candidate,genes |
R4651 |
T15013 |
T15014 |
nsubjpass |
genes,selected |
R4652 |
T15015 |
T15014 |
aux |
will,selected |
R4653 |
T15016 |
T15014 |
auxpass |
be,selected |
R4654 |
T15017 |
T15014 |
prep |
according,selected |
R4655 |
T15018 |
T15017 |
prep |
to,according |
R4656 |
T15019 |
T15020 |
poss |
their,function |
R4657 |
T15020 |
T15018 |
pobj |
function,to |
R4658 |
T15021 |
T15020 |
cc |
and,function |
R4659 |
T15022 |
T15020 |
conj |
polymorphism,function |
R4660 |
T15023 |
T15022 |
prep |
between,polymorphism |
R4661 |
T15024 |
T15025 |
det |
the,strains |
R4662 |
T15025 |
T15023 |
pobj |
strains,between |
R4663 |
T15026 |
T15025 |
nummod |
two,strains |
R4664 |
T15027 |
T15014 |
punct |
.,selected |
R4665 |
T15029 |
T15030 |
advmod |
Thereafter,generate |
R4666 |
T15031 |
T15030 |
punct |
", ",generate |
R4667 |
T15032 |
T15030 |
nsubj |
we,generate |
R4668 |
T15033 |
T15030 |
aux |
will,generate |
R4669 |
T15034 |
T15035 |
amod |
knock,mice |
R4670 |
T15035 |
T15030 |
dobj |
mice,generate |
R4671 |
T15036 |
T15034 |
punct |
-,knock |
R4672 |
T15037 |
T15034 |
prt |
out,knock |
R4673 |
T15038 |
T15039 |
aux |
to,investigate |
R4674 |
T15039 |
T15030 |
advcl |
investigate,generate |
R4675 |
T15040 |
T15041 |
det |
the,role |
R4676 |
T15041 |
T15039 |
dobj |
role,investigate |
R4677 |
T15042 |
T15041 |
prep |
of,role |
R4678 |
T15043 |
T15044 |
det |
the,genes |
R4679 |
T15044 |
T15042 |
pobj |
genes,of |
R4680 |
T15045 |
T15039 |
prep |
in,investigate |
R4681 |
T15046 |
T15045 |
pobj |
CIA,in |
R4682 |
T15047 |
T15030 |
punct |
.,generate |
R4683 |
T15049 |
T15050 |
prep |
For,investigate |
R4684 |
T15051 |
T15052 |
det |
the,loci |
R4685 |
T15052 |
T15049 |
pobj |
loci,For |
R4686 |
T15053 |
T15054 |
poss |
whose,counterparts |
R4687 |
T15054 |
T15055 |
dep |
counterparts,linked |
R4688 |
T15055 |
T15052 |
relcl |
linked,loci |
R4689 |
T15056 |
T15054 |
prep |
on,counterparts |
R4690 |
T15057 |
T15058 |
det |
the,genome |
R4691 |
T15058 |
T15056 |
pobj |
genome,on |
R4692 |
T15059 |
T15058 |
amod |
human,genome |
R4693 |
T15060 |
T15055 |
auxpass |
are,linked |
R4694 |
T15061 |
T15055 |
prep |
to,linked |
R4695 |
T15062 |
T15061 |
pobj |
RA,to |
R4696 |
T15063 |
T15050 |
punct |
", ",investigate |
R4697 |
T15064 |
T15050 |
nsubj |
we,investigate |
R4698 |
T15065 |
T15050 |
aux |
will,investigate |
R4699 |
T15066 |
T15067 |
det |
the,genes |
R4700 |
T15067 |
T15050 |
dobj |
genes,investigate |
R4701 |
T15068 |
T15067 |
compound |
candidate,genes |
R4702 |
T15069 |
T15050 |
advcl |
using,investigate |
R4703 |
T15070 |
T15071 |
compound |
case,control |
R4704 |
T15071 |
T15073 |
compound |
control,studies |
R4705 |
T15072 |
T15071 |
punct |
-,control |
R4706 |
T15073 |
T15069 |
dobj |
studies,using |
R4707 |
T15074 |
T15073 |
compound |
association,studies |
R4708 |
T15075 |
T15069 |
prep |
in,using |
R4709 |
T15076 |
T15077 |
compound |
RA,cohorts |
R4710 |
T15077 |
T15075 |
pobj |
cohorts,in |
R4711 |
T15078 |
T15050 |
punct |
.,investigate |