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we have presented a strategy to identify small-effect QTL and search for potential candidate genes within them. However, it is noteworthy that the low statistical threshold and small number of animals per group could lead to some false positive results. On the genome level, some of the eight small-effect QTL identified using a very low threshold value (P \u003c 0.05) could be false positives. For example, locus 4 was identified with a low P value and does not overlap with any previously identified arthritis QTL. On the transcriptome level, the small number of animals per group and the low threshold used to detect gene expression could also result in false positives in the differentially expressed genes. Furthermore, the differential expression of a gene could result not only from allele difference between two strains, but also from other factors. Therefore, our findings should be confirmed in future studies."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T13475","span":{"begin":627,"end":642},"obj":"GO:0010467"},{"id":"T13476","span":{"begin":702,"end":711},"obj":"GO:0010467"},{"id":"T13477","span":{"begin":712,"end":717},"obj":"SO_EXT:0000704"},{"id":"T13478","span":{"begin":749,"end":759},"obj":"GO:0010467"},{"id":"T13479","span":{"begin":765,"end":769},"obj":"SO_EXT:0000704"},{"id":"T13480","span":{"begin":797,"end":803},"obj":"SO_EXT:0001023"},{"id":"T13467","span":{"begin":65,"end":68},"obj":"SO_EXT:0000771"},{"id":"T13468","span":{"begin":104,"end":109},"obj":"SO_EXT:0000704"},{"id":"T13469","span":{"begin":204,"end":211},"obj":"NCBITaxon:33208"},{"id":"T13470","span":{"begin":272,"end":278},"obj":"SO_EXT:0001026"},{"id":"T13471","span":{"begin":317,"end":320},"obj":"SO_EXT:0000771"},{"id":"T13472","span":{"begin":519,"end":522},"obj":"SO_EXT:0000771"},{"id":"T13473","span":{"begin":572,"end":579},"obj":"NCBITaxon:33208"},{"id":"T13474","span":{"begin":627,"end":631},"obj":"SO_EXT:0000704"}],"text":"Therefore, we have presented a strategy to identify small-effect QTL and search for potential candidate genes within them. However, it is noteworthy that the low statistical threshold and small number of animals per group could lead to some false positive results. On the genome level, some of the eight small-effect QTL identified using a very low threshold value (P \u003c 0.05) could be false positives. For example, locus 4 was identified with a low P value and does not overlap with any previously identified arthritis QTL. On the transcriptome level, the small number of animals per group and the low threshold used to detect gene expression could also result in false positives in the differentially expressed genes. Furthermore, the differential expression of a gene could result not only from allele difference between two strains, but also from other factors. Therefore, our findings should be confirmed in future studies."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T13307","span":{"begin":65,"end":68},"obj":"SO:0000771"},{"id":"T13308","span":{"begin":104,"end":109},"obj":"SO:0000704"},{"id":"T13309","span":{"begin":204,"end":211},"obj":"NCBITaxon:33208"},{"id":"T13310","span":{"begin":272,"end":278},"obj":"SO:0001026"},{"id":"T13311","span":{"begin":317,"end":320},"obj":"SO:0000771"},{"id":"T13312","span":{"begin":519,"end":522},"obj":"SO:0000771"},{"id":"T13313","span":{"begin":572,"end":579},"obj":"NCBITaxon:33208"},{"id":"T13314","span":{"begin":627,"end":631},"obj":"SO:0000704"},{"id":"T13315","span":{"begin":627,"end":642},"obj":"GO:0010467"},{"id":"T13316","span":{"begin":702,"end":711},"obj":"GO:0010467"},{"id":"T13317","span":{"begin":712,"end":717},"obj":"SO:0000704"},{"id":"T13318","span":{"begin":749,"end":759},"obj":"GO:0010467"},{"id":"T13319","span":{"begin":765,"end":769},"obj":"SO:0000704"},{"id":"T13320","span":{"begin":797,"end":803},"obj":"SO:0001023"}],"text":"Therefore, we have presented a strategy to identify small-effect QTL and search for potential candidate genes within them. However, it is noteworthy that the low statistical threshold and small number of animals per group could lead to some false positive results. On the genome level, some of the eight small-effect QTL identified using a very low threshold value (P \u003c 0.05) could be false positives. For example, locus 4 was identified with a low P value and does not overlap with any previously identified arthritis QTL. On the transcriptome level, the small number of animals per group and the low threshold used to detect gene expression could also result in false positives in the differentially expressed genes. Furthermore, the differential expression of a gene could result not only from allele difference between two strains, but also from other factors. Therefore, our findings should be confirmed in future studies."}