PMC:1860061 / 1269-27666 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T5781	8716-8726	NN	denotes	expression
T5782	8734-8736	IN	denotes	of
T5783	8737-8740	DT	denotes	the
T5784	8745-8750	NNS	denotes	genes
T5785	8741-8744	CD	denotes	two
T5786	8751-8757	IN	denotes	across
T5787	8758-8761	DT	denotes	the
T5788	8762-8769	NNS	denotes	samples
T2422	13-27	NN	denotes	Susceptibility
T2423	56-66	VBN	denotes	controlled
T2424	28-30	IN	denotes	to
T2425	31-35	RBS	denotes	most
T2426	44-52	NNS	denotes	diseases
T2427	36-43	JJ	denotes	complex
T2428	53-55	VBZ	denotes	is
T2429	67-69	IN	denotes	by
T2430	70-74	JJ	denotes	many
T2431	75-80	NNS	denotes	genes
T2432	80-82	,	denotes	,
T2433	82-86	RB	denotes	each
T2434	87-93	VBG	denotes	having
T2435	94-95	DT	denotes	a
T2436	102-108	NN	denotes	effect
T2437	96-101	JJ	denotes	small
T2438	109-111	IN	denotes	on
T2439	112-115	DT	denotes	the
T2440	116-123	NN	denotes	disease
T2441	123-124	.	denotes	.
T2442	124-218	sentence	denotes	One example is rheumatoid arthritis (RA), a common complex multifactorial autoimmune disease.
T2443	125-128	CD	denotes	One
T2444	129-136	NN	denotes	example
T2445	137-139	VBZ	denotes	is
T2446	140-150	JJ	denotes	rheumatoid
T2447	151-160	NN	denotes	arthritis
T2448	161-162	-LRB-	denotes	(
T2449	162-164	NN	denotes	RA
T2450	164-165	-RRB-	denotes	)
T2451	165-167	,	denotes	,
T2452	167-168	DT	denotes	a
T2453	210-217	NN	denotes	disease
T2454	169-175	JJ	denotes	common
T2455	176-183	NN	denotes	complex
T2456	184-198	JJ	denotes	multifactorial
T2457	199-209	JJ	denotes	autoimmune
T2458	217-218	.	denotes	.
T2459	218-371	sentence	denotes	Several studies have been carried out to detect the genetic basis of RA, and more than 30 genomic regions have shown evidence of linkage to the disease.
T2460	219-226	JJ	denotes	Several
T2461	227-234	NNS	denotes	studies
T2462	245-252	VBN	denotes	carried
T2463	235-239	VBP	denotes	have
T2464	240-244	VBN	denotes	been
T2465	253-256	RP	denotes	out
T2466	257-259	TO	denotes	to
T2467	260-266	VB	denotes	detect
T2468	267-270	DT	denotes	the
T2469	279-284	NN	denotes	basis
T2470	271-278	JJ	denotes	genetic
T2471	285-287	IN	denotes	of
T2472	288-290	NN	denotes	RA
T2473	290-292	,	denotes	,
T2474	292-295	CC	denotes	and
T2475	296-300	JJR	denotes	more
T2476	306-308	CD	denotes	30
T2477	301-305	IN	denotes	than
T2478	317-324	NNS	denotes	regions
T2479	309-316	JJ	denotes	genomic
T2480	330-335	VBN	denotes	shown
T2481	325-329	VBP	denotes	have
T2482	336-344	NN	denotes	evidence
T2483	345-347	IN	denotes	of
T2484	348-355	NN	denotes	linkage
T2485	356-358	IN	denotes	to
T2486	359-362	DT	denotes	the
T2487	363-370	NN	denotes	disease
T2488	370-371	.	denotes	.
T2489	371-513	sentence	denotes	Most of these genomic regions did not reach a genome-wide significant threshold value of linkage, with P values between 0.05 and 0.001 [1-5].
T2490	372-376	JJS	denotes	Most
T2491	410-415	VB	denotes	reach
T2492	377-379	IN	denotes	of
T2493	380-385	DT	denotes	these
T2494	394-401	NNS	denotes	regions
T2495	386-393	JJ	denotes	genomic
T2496	402-405	VBD	denotes	did
T2497	406-409	RB	denotes	not
T2498	416-417	DT	denotes	a
T2499	452-457	NN	denotes	value
T2500	418-424	NN	denotes	genome
T2501	425-429	JJ	denotes	wide
T2502	424-425	HYPH	denotes	-
T2503	430-441	JJ	denotes	significant
T2504	442-451	NN	denotes	threshold
T2505	458-460	IN	denotes	of
T2506	461-468	NN	denotes	linkage
T2507	468-470	,	denotes	,
T2508	470-474	IN	denotes	with
T2509	475-476	NN	denotes	P
T2510	477-483	NNS	denotes	values
T2511	484-491	IN	denotes	between
T2512	492-496	CD	denotes	0.05
T2513	497-500	CC	denotes	and
T2514	501-506	CD	denotes	0.001
T2515	507-508	-LRB-	denotes	[
T2516	508-509	CD	denotes	1
T2517	509-510	SYM	denotes	-
T2518	510-511	CD	denotes	5
T2519	511-512	-RRB-	denotes	]
T2520	512-513	.	denotes	.
T2521	513-562	sentence	denotes	Thus, these loci only have a small effect on RA.
T2522	514-518	RB	denotes	Thus
T2523	536-540	VBP	denotes	have
T2524	518-520	,	denotes	,
T2525	520-525	DT	denotes	these
T2526	526-530	NNS	denotes	loci
T2527	531-535	RB	denotes	only
T2528	541-542	DT	denotes	a
T2529	549-555	NN	denotes	effect
T2530	543-548	JJ	denotes	small
T2531	556-558	IN	denotes	on
T2532	559-561	NN	denotes	RA
T2533	561-562	.	denotes	.
T2534	562-714	sentence	denotes	Small genetic contributions could also be seen from the susceptibility genes of RA identified so far, including HLA-DR4, PADI4, PTPN22 and FCRL3 [6-9].
T2535	563-568	JJ	denotes	Small
T2536	577-590	NNS	denotes	contributions
T2537	569-576	JJ	denotes	genetic
T2538	605-609	VBN	denotes	seen
T2539	591-596	MD	denotes	could
T2540	597-601	RB	denotes	also
T2541	602-604	VB	denotes	be
T2542	610-614	IN	denotes	from
T2543	615-618	DT	denotes	the
T2544	634-639	NNS	denotes	genes
T2545	619-633	NN	denotes	susceptibility
T2546	640-642	IN	denotes	of
T2547	643-645	NN	denotes	RA
T2548	646-656	VBN	denotes	identified
T2549	657-659	RB	denotes	so
T2550	660-663	RB	denotes	far
T2551	663-665	,	denotes	,
T2552	665-674	VBG	denotes	including
T2553	675-678	NN	denotes	HLA
T2554	679-682	NN	denotes	DR4
T2555	678-679	HYPH	denotes	-
T2556	682-684	,	denotes	,
T2557	684-689	NN	denotes	PADI4
T2558	689-691	,	denotes	,
T2559	691-697	NN	denotes	PTPN22
T2560	698-701	CC	denotes	and
T2561	702-707	NN	denotes	FCRL3
T2562	708-709	-LRB-	denotes	[
T2563	709-710	CD	denotes	6
T2564	710-711	SYM	denotes	-
T2565	711-712	CD	denotes	9
T2566	712-713	-RRB-	denotes	]
T2567	713-714	.	denotes	.
T2568	714-848	sentence	denotes	Except for HLA-DR4, which is strongly associated with RA, all the other susceptibility genes have only a small effect on the disease.
T2569	715-721	IN	denotes	Except
T2570	808-812	VBP	denotes	have
T2571	722-725	IN	denotes	for
T2572	726-729	NN	denotes	HLA
T2573	730-733	NN	denotes	DR4
T2574	729-730	HYPH	denotes	-
T2575	733-735	,	denotes	,
T2576	735-740	WDT	denotes	which
T2577	753-763	VBN	denotes	associated
T2578	741-743	VBZ	denotes	is
T2579	744-752	RB	denotes	strongly
T2580	764-768	IN	denotes	with
T2581	769-771	NN	denotes	RA
T2582	771-773	,	denotes	,
T2583	773-776	PDT	denotes	all
T2584	802-807	NNS	denotes	genes
T2585	777-780	DT	denotes	the
T2586	781-786	JJ	denotes	other
T2587	787-801	NN	denotes	susceptibility
T2588	813-817	RB	denotes	only
T2589	826-832	NN	denotes	effect
T2590	818-819	DT	denotes	a
T2591	820-825	JJ	denotes	small
T2592	833-835	IN	denotes	on
T2593	836-839	DT	denotes	the
T2594	840-847	NN	denotes	disease
T2595	847-848	.	denotes	.
T2596	848-927	sentence	denotes	In the mouse model of RA, small genetic contributions are also often observed.
T2597	849-851	IN	denotes	In
T2598	918-926	VBN	denotes	observed
T2599	852-855	DT	denotes	the
T2600	862-867	NN	denotes	model
T2601	856-861	NN	denotes	mouse
T2602	868-870	IN	denotes	of
T2603	871-873	NN	denotes	RA
T2604	873-875	,	denotes	,
T2605	875-880	JJ	denotes	small
T2606	889-902	NNS	denotes	contributions
T2607	881-888	JJ	denotes	genetic
T2608	903-906	VBP	denotes	are
T2609	907-911	RB	denotes	also
T2610	912-917	RB	denotes	often
T2611	926-927	.	denotes	.
T2612	927-1118	sentence	denotes	For example, in a previous study, we carried out a genome screen to identify the quantitative trait loci (QTL) in collagen-induced arthritis (CIA), which is a widely used animal model of RA.
T2613	928-931	IN	denotes	For
T2614	965-972	VBD	denotes	carried
T2615	932-939	NN	denotes	example
T2616	939-941	,	denotes	,
T2617	941-943	IN	denotes	in
T2618	944-945	DT	denotes	a
T2619	955-960	NN	denotes	study
T2620	946-954	JJ	denotes	previous
T2621	960-962	,	denotes	,
T2622	962-964	PRP	denotes	we
T2623	973-976	RP	denotes	out
T2624	977-978	DT	denotes	a
T2625	986-992	NN	denotes	screen
T2626	979-985	NN	denotes	genome
T2627	993-995	TO	denotes	to
T2628	996-1004	VB	denotes	identify
T2629	1005-1008	DT	denotes	the
T2630	1028-1032	NNS	denotes	loci
T2631	1009-1021	JJ	denotes	quantitative
T2632	1022-1027	NN	denotes	trait
T2633	1033-1034	-LRB-	denotes	(
T2634	1034-1037	NN	denotes	QTL
T2635	1037-1038	-RRB-	denotes	)
T2636	1039-1041	IN	denotes	in
T2637	1042-1050	NN	denotes	collagen
T2638	1051-1058	VBN	denotes	induced
T2639	1050-1051	HYPH	denotes	-
T2640	1059-1068	NN	denotes	arthritis
T2641	1069-1070	-LRB-	denotes	(
T2642	1070-1073	NN	denotes	CIA
T2643	1073-1074	-RRB-	denotes	)
T2644	1074-1076	,	denotes	,
T2645	1076-1081	WDT	denotes	which
T2646	1082-1084	VBZ	denotes	is
T2647	1085-1086	DT	denotes	a
T2648	1106-1111	NN	denotes	model
T2649	1087-1093	RB	denotes	widely
T2650	1094-1098	VBN	denotes	used
T2651	1099-1105	NN	denotes	animal
T2652	1112-1114	IN	denotes	of
T2653	1115-1117	NN	denotes	RA
T2654	1117-1118	.	denotes	.
T2655	1118-1296	sentence	denotes	Only one QTL, Cia2, was identified for the phenotype of CIA severity, but this QTL contributes to only 16% of the phenotype variations for CIA susceptibility in F2 progeny [10].
T2656	1119-1123	RB	denotes	Only
T2657	1128-1131	NN	denotes	QTL
T2658	1124-1127	CD	denotes	one
T2659	1143-1153	VBN	denotes	identified
T2660	1131-1133	,	denotes	,
T2661	1133-1137	NN	denotes	Cia2
T2662	1137-1139	,	denotes	,
T2663	1139-1142	VBD	denotes	was
T2664	1154-1157	IN	denotes	for
T2665	1158-1161	DT	denotes	the
T2666	1162-1171	NN	denotes	phenotype
T2667	1172-1174	IN	denotes	of
T2668	1175-1178	NN	denotes	CIA
T2669	1179-1187	NN	denotes	severity
T2670	1187-1189	,	denotes	,
T2671	1189-1192	CC	denotes	but
T2672	1193-1197	DT	denotes	this
T2673	1198-1201	NN	denotes	QTL
T2674	1202-1213	VBZ	denotes	contributes
T2675	1214-1216	IN	denotes	to
T2676	1217-1221	RB	denotes	only
T2677	1222-1224	CD	denotes	16
T2678	1224-1225	NN	denotes	%
T2679	1226-1228	IN	denotes	of
T2680	1229-1232	DT	denotes	the
T2681	1243-1253	NNS	denotes	variations
T2682	1233-1242	NN	denotes	phenotype
T2683	1254-1257	IN	denotes	for
T2684	1258-1261	NN	denotes	CIA
T2685	1262-1276	NN	denotes	susceptibility
T2686	1277-1279	IN	denotes	in
T2687	1280-1282	NN	denotes	F2
T2688	1283-1290	NN	denotes	progeny
T2689	1291-1292	-LRB-	denotes	[
T2690	1292-1294	CD	denotes	10
T2691	1294-1295	-RRB-	denotes	]
T2692	1295-1296	.	denotes	.
T2693	1296-1469	sentence	denotes	This suggests that there must be other susceptibility genes whose contributions were not big enough to reach the stringent significance threshold value of linkage analysis.
T2694	1297-1301	DT	denotes	This
T2695	1302-1310	VBZ	denotes	suggests
T2696	1311-1315	IN	denotes	that
T2697	1327-1329	VB	denotes	be
T2698	1316-1321	EX	denotes	there
T2699	1322-1326	MD	denotes	must
T2700	1330-1335	JJ	denotes	other
T2701	1351-1356	NNS	denotes	genes
T2702	1336-1350	NN	denotes	susceptibility
T2703	1357-1362	WP$	denotes	whose
T2704	1363-1376	NNS	denotes	contributions
T2705	1377-1381	VBD	denotes	were
T2706	1382-1385	RB	denotes	not
T2707	1386-1389	JJ	denotes	big
T2708	1390-1396	RB	denotes	enough
T2709	1397-1399	TO	denotes	to
T2710	1400-1405	VB	denotes	reach
T2711	1406-1409	DT	denotes	the
T2712	1443-1448	NN	denotes	value
T2713	1410-1419	JJ	denotes	stringent
T2714	1420-1432	NN	denotes	significance
T2715	1433-1442	NN	denotes	threshold
T2716	1449-1451	IN	denotes	of
T2717	1452-1459	NN	denotes	linkage
T2718	1460-1468	NN	denotes	analysis
T2719	1468-1469	.	denotes	.
T2720	1469-1571	sentence	denotes	One aim of using animal models for complex diseases is to detect the genetic basis of these diseases.
T2721	1470-1473	CD	denotes	One
T2722	1474-1477	NN	denotes	aim
T2723	1522-1524	VBZ	denotes	is
T2724	1478-1480	IN	denotes	of
T2725	1481-1486	VBG	denotes	using
T2726	1487-1493	NN	denotes	animal
T2727	1494-1500	NNS	denotes	models
T2728	1501-1504	IN	denotes	for
T2729	1505-1512	JJ	denotes	complex
T2730	1513-1521	NNS	denotes	diseases
T2731	1525-1527	TO	denotes	to
T2732	1528-1534	VB	denotes	detect
T2733	1535-1538	DT	denotes	the
T2734	1547-1552	NN	denotes	basis
T2735	1539-1546	JJ	denotes	genetic
T2736	1553-1555	IN	denotes	of
T2737	1556-1561	DT	denotes	these
T2738	1562-1570	NNS	denotes	diseases
T2739	1570-1571	.	denotes	.
T2740	1571-1795	sentence	denotes	With controllable environmental factors as well as the known genetic background, animal models are powerful tools to search for susceptibility genes for complex diseases, and have been intensively employed for that purpose.
T2741	1572-1576	IN	denotes	With
T2742	1667-1670	VBP	denotes	are
T2743	1577-1589	JJ	denotes	controllable
T2744	1604-1611	NNS	denotes	factors
T2745	1590-1603	JJ	denotes	environmental
T2746	1612-1614	RB	denotes	as
T2747	1620-1622	IN	denotes	as
T2748	1615-1619	RB	denotes	well
T2749	1623-1626	DT	denotes	the
T2750	1641-1651	NN	denotes	background
T2751	1627-1632	JJ	denotes	known
T2752	1633-1640	JJ	denotes	genetic
T2753	1651-1653	,	denotes	,
T2754	1653-1659	NN	denotes	animal
T2755	1660-1666	NNS	denotes	models
T2756	1671-1679	JJ	denotes	powerful
T2757	1680-1685	NNS	denotes	tools
T2758	1686-1688	TO	denotes	to
T2759	1689-1695	VB	denotes	search
T2760	1696-1699	IN	denotes	for
T2761	1700-1714	NN	denotes	susceptibility
T2762	1715-1720	NNS	denotes	genes
T2763	1721-1724	IN	denotes	for
T2764	1725-1732	JJ	denotes	complex
T2765	1733-1741	NNS	denotes	diseases
T2766	1741-1743	,	denotes	,
T2767	1743-1746	CC	denotes	and
T2768	1747-1751	VBP	denotes	have
T2769	1769-1777	VBN	denotes	employed
T2770	1752-1756	VBN	denotes	been
T2771	1757-1768	RB	denotes	intensively
T2772	1778-1781	IN	denotes	for
T2773	1782-1786	DT	denotes	that
T2774	1787-1794	NN	denotes	purpose
T2775	1794-1795	.	denotes	.
T2776	1795-1928	sentence	denotes	More than 27,000 QTL have been identified in the mouse genome since the first QTL was identified at the beginning of the 1990s [11].
T2777	1796-1800	JJR	denotes	More
T2778	1806-1812	CD	denotes	27,000
T2779	1801-1805	IN	denotes	than
T2780	1813-1816	NN	denotes	QTL
T2781	1827-1837	VBN	denotes	identified
T2782	1817-1821	VBP	denotes	have
T2783	1822-1826	VBN	denotes	been
T2784	1838-1840	IN	denotes	in
T2785	1841-1844	DT	denotes	the
T2786	1851-1857	NN	denotes	genome
T2787	1845-1850	NN	denotes	mouse
T2788	1858-1863	IN	denotes	since
T2789	1882-1892	VBN	denotes	identified
T2790	1864-1867	DT	denotes	the
T2791	1874-1877	NN	denotes	QTL
T2792	1868-1873	JJ	denotes	first
T2793	1878-1881	VBD	denotes	was
T2794	1893-1895	IN	denotes	at
T2795	1896-1899	DT	denotes	the
T2796	1900-1909	NN	denotes	beginning
T2797	1910-1912	IN	denotes	of
T2798	1913-1916	DT	denotes	the
T2799	1917-1922	NNS	denotes	1990s
T2800	1923-1924	-LRB-	denotes	[
T2801	1924-1926	CD	denotes	11
T2802	1926-1927	-RRB-	denotes	]
T2803	1927-1928	.	denotes	.
T2804	1928-2035	sentence	denotes	By 2005, approximately 20 quantitative trait genes (QTGs) in the mouse genome had been identified [12,13].
T2805	1929-1931	IN	denotes	By
T2806	2016-2026	VBN	denotes	identified
T2807	1932-1936	CD	denotes	2005
T2808	1936-1938	,	denotes	,
T2809	1938-1951	RB	denotes	approximately
T2810	1952-1954	CD	denotes	20
T2811	1974-1979	NNS	denotes	genes
T2812	1955-1967	JJ	denotes	quantitative
T2813	1968-1973	NN	denotes	trait
T2814	1980-1981	-LRB-	denotes	(
T2815	1981-1985	NNS	denotes	QTGs
T2816	1985-1986	-RRB-	denotes	)
T2817	1987-1989	IN	denotes	in
T2818	1990-1993	DT	denotes	the
T2819	2000-2006	NN	denotes	genome
T2820	1994-1999	NN	denotes	mouse
T2821	2007-2010	VBD	denotes	had
T2822	2011-2015	VBN	denotes	been
T2823	2027-2028	-LRB-	denotes	[
T2824	2031-2033	CD	denotes	13
T2825	2028-2030	CD	denotes	12
T2826	2030-2031	,	denotes	,
T2827	2033-2034	-RRB-	denotes	]
T2828	2034-2035	.	denotes	.
T2829	2035-2216	sentence	denotes	Interestingly, most QTGs identified in animal models have the causal polymorphisms in the protein-coding region [14], which provoke protein structure changes or protein deficiency.
T2830	2036-2049	RB	denotes	Interestingly
T2831	2089-2093	VBP	denotes	have
T2832	2049-2051	,	denotes	,
T2833	2051-2055	JJS	denotes	most
T2834	2056-2060	NNS	denotes	QTGs
T2835	2061-2071	VBN	denotes	identified
T2836	2072-2074	IN	denotes	in
T2837	2075-2081	NN	denotes	animal
T2838	2082-2088	NNS	denotes	models
T2839	2094-2097	DT	denotes	the
T2840	2105-2118	NNS	denotes	polymorphisms
T2841	2098-2104	JJ	denotes	causal
T2842	2119-2121	IN	denotes	in
T2843	2122-2125	DT	denotes	the
T2844	2141-2147	NN	denotes	region
T2845	2126-2133	NN	denotes	protein
T2846	2134-2140	VBG	denotes	coding
T2847	2133-2134	HYPH	denotes	-
T2848	2148-2149	-LRB-	denotes	[
T2849	2149-2151	CD	denotes	14
T2850	2151-2152	-RRB-	denotes	]
T2851	2152-2154	,	denotes	,
T2852	2154-2159	WDT	denotes	which
T2853	2160-2167	VBP	denotes	provoke
T2854	2168-2175	NN	denotes	protein
T2855	2186-2193	NNS	denotes	changes
T2856	2176-2185	NN	denotes	structure
T2857	2194-2196	CC	denotes	or
T2858	2197-2204	NN	denotes	protein
T2859	2205-2215	NN	denotes	deficiency
T2860	2215-2216	.	denotes	.
T2861	2216-2491	sentence	denotes	This suggests, on the one hand, that small-effect QTL are difficult to identify with traditional strategies and, on the other hand, that the polymorphisms regulating gene expression might only slightly affect the quantitative traits, and thus are more difficult to identify.
T2862	2217-2221	DT	denotes	This
T2863	2222-2230	VBZ	denotes	suggests
T2864	2230-2232	,	denotes	,
T2865	2232-2234	IN	denotes	on
T2866	2271-2274	VBP	denotes	are
T2867	2235-2238	DT	denotes	the
T2868	2243-2247	NN	denotes	hand
T2869	2239-2242	CD	denotes	one
T2870	2247-2249	,	denotes	,
T2871	2249-2253	IN	denotes	that
T2872	2254-2259	JJ	denotes	small
T2873	2260-2266	NN	denotes	effect
T2874	2259-2260	HYPH	denotes	-
T2875	2267-2270	NN	denotes	QTL
T2876	2275-2284	JJ	denotes	difficult
T2877	2285-2287	TO	denotes	to
T2878	2288-2296	VB	denotes	identify
T2879	2297-2301	IN	denotes	with
T2880	2302-2313	JJ	denotes	traditional
T2881	2314-2324	NNS	denotes	strategies
T2882	2325-2328	CC	denotes	and
T2883	2328-2330	,	denotes	,
T2884	2330-2332	IN	denotes	on
T2885	2419-2425	VB	denotes	affect
T2886	2333-2336	DT	denotes	the
T2887	2343-2347	NN	denotes	hand
T2888	2337-2342	JJ	denotes	other
T2889	2347-2349	,	denotes	,
T2890	2349-2353	IN	denotes	that
T2891	2354-2357	DT	denotes	the
T2892	2358-2371	NNS	denotes	polymorphisms
T2893	2372-2382	VBG	denotes	regulating
T2894	2383-2387	NN	denotes	gene
T2895	2388-2398	NN	denotes	expression
T2896	2399-2404	MD	denotes	might
T2897	2405-2409	RB	denotes	only
T2898	2410-2418	RB	denotes	slightly
T2899	2426-2429	DT	denotes	the
T2900	2443-2449	NNS	denotes	traits
T2901	2430-2442	JJ	denotes	quantitative
T2902	2449-2451	,	denotes	,
T2903	2451-2454	CC	denotes	and
T2904	2455-2459	RB	denotes	thus
T2905	2460-2463	VBP	denotes	are
T2906	2464-2468	RBR	denotes	more
T2907	2469-2478	JJ	denotes	difficult
T2908	2479-2481	TO	denotes	to
T2909	2482-2490	VB	denotes	identify
T2910	2490-2491	.	denotes	.
T2911	2491-2591	sentence	denotes	Microarray-based global gene expression is a powerful technique for investigating complex diseases.
T2912	2492-2502	NN	denotes	Microarray
T2913	2503-2508	VBN	denotes	based
T2914	2502-2503	HYPH	denotes	-
T2915	2521-2531	NN	denotes	expression
T2916	2509-2515	JJ	denotes	global
T2917	2516-2520	NN	denotes	gene
T2918	2532-2534	VBZ	denotes	is
T2919	2535-2536	DT	denotes	a
T2920	2546-2555	NN	denotes	technique
T2921	2537-2545	JJ	denotes	powerful
T2922	2556-2559	IN	denotes	for
T2923	2560-2573	VBG	denotes	investigating
T2924	2574-2581	JJ	denotes	complex
T2925	2582-2590	NNS	denotes	diseases
T2926	2590-2591	.	denotes	.
T2927	2591-2692	sentence	denotes	During disease development, genes involved in the disease are likely to be differentially regulated.
T2928	2592-2598	IN	denotes	During
T2929	2650-2653	VBP	denotes	are
T2930	2599-2606	NN	denotes	disease
T2931	2607-2618	NN	denotes	development
T2932	2618-2620	,	denotes	,
T2933	2620-2625	NNS	denotes	genes
T2934	2626-2634	VBN	denotes	involved
T2935	2635-2637	IN	denotes	in
T2936	2638-2641	DT	denotes	the
T2937	2642-2649	NN	denotes	disease
T2938	2654-2660	JJ	denotes	likely
T2939	2661-2663	TO	denotes	to
T2940	2682-2691	VBN	denotes	regulated
T2941	2664-2666	VB	denotes	be
T2942	2667-2681	RB	denotes	differentially
T2943	2691-2692	.	denotes	.
T2944	2692-2855	sentence	denotes	Therefore, signature genes of the diseases could be identified by detecting the expression patterns of the disease-related cells/tissues and their ideal controls.
T2945	2693-2702	RB	denotes	Therefore
T2946	2745-2755	VBN	denotes	identified
T2947	2702-2704	,	denotes	,
T2948	2704-2713	NN	denotes	signature
T2949	2714-2719	NNS	denotes	genes
T2950	2720-2722	IN	denotes	of
T2951	2723-2726	DT	denotes	the
T2952	2727-2735	NNS	denotes	diseases
T2953	2736-2741	MD	denotes	could
T2954	2742-2744	VB	denotes	be
T2955	2756-2758	IN	denotes	by
T2956	2759-2768	VBG	denotes	detecting
T2957	2769-2772	DT	denotes	the
T2958	2784-2792	NNS	denotes	patterns
T2959	2773-2783	NN	denotes	expression
T2960	2793-2795	IN	denotes	of
T2961	2796-2799	DT	denotes	the
T2962	2822-2829	NNS	denotes	tissues
T2963	2800-2807	NN	denotes	disease
T2964	2808-2815	VBN	denotes	related
T2965	2807-2808	HYPH	denotes	-
T2966	2816-2821	NNS	denotes	cells
T2967	2821-2822	HYPH	denotes	/
T2968	2830-2833	CC	denotes	and
T2969	2834-2839	PRP$	denotes	their
T2970	2846-2854	NNS	denotes	controls
T2971	2840-2845	JJ	denotes	ideal
T2972	2854-2855	.	denotes	.
T2973	2855-2959	sentence	denotes	In the past decade, many studies applied this technique to study both RA and its animal models [15-22].
T2974	2856-2858	IN	denotes	In
T2975	2889-2896	VBD	denotes	applied
T2976	2859-2862	DT	denotes	the
T2977	2868-2874	NN	denotes	decade
T2978	2863-2867	JJ	denotes	past
T2979	2874-2876	,	denotes	,
T2980	2876-2880	JJ	denotes	many
T2981	2881-2888	NNS	denotes	studies
T2982	2897-2901	DT	denotes	this
T2983	2902-2911	NN	denotes	technique
T2984	2912-2914	TO	denotes	to
T2985	2915-2920	VB	denotes	study
T2986	2921-2925	CC	denotes	both
T2987	2926-2928	NN	denotes	RA
T2988	2929-2932	CC	denotes	and
T2989	2933-2936	PRP$	denotes	its
T2990	2944-2950	NNS	denotes	models
T2991	2937-2943	NN	denotes	animal
T2992	2951-2952	-LRB-	denotes	[
T2993	2952-2954	CD	denotes	15
T2994	2954-2955	SYM	denotes	-
T2995	2955-2957	CD	denotes	22
T2996	2957-2958	-RRB-	denotes	]
T2997	2958-2959	.	denotes	.
T2998	2959-3088	sentence	denotes	Indeed, genes involved in arthritis show distinct expression patterns in certain tissues and pathological stages of the disease.
T2999	2960-2966	RB	denotes	Indeed
T3000	2996-3000	VBP	denotes	show
T3001	2966-2968	,	denotes	,
T3002	2968-2973	NNS	denotes	genes
T3003	2974-2982	VBN	denotes	involved
T3004	2983-2985	IN	denotes	in
T3005	2986-2995	NN	denotes	arthritis
T3006	3001-3009	JJ	denotes	distinct
T3007	3021-3029	NNS	denotes	patterns
T3008	3010-3020	NN	denotes	expression
T3009	3030-3032	IN	denotes	in
T3010	3033-3040	JJ	denotes	certain
T3011	3041-3048	NNS	denotes	tissues
T3012	3049-3052	CC	denotes	and
T3013	3053-3065	JJ	denotes	pathological
T3014	3066-3072	NNS	denotes	stages
T3015	3073-3075	IN	denotes	of
T3016	3076-3079	DT	denotes	the
T3017	3080-3087	NN	denotes	disease
T3018	3087-3088	.	denotes	.
T3019	3088-3205	sentence	denotes	Genes involved in immunoinflammatory responses were differentially expressed in the blood cells in RA patients [18].
T3020	3089-3094	NNS	denotes	Genes
T3021	3156-3165	VBN	denotes	expressed
T3022	3095-3103	VBN	denotes	involved
T3023	3104-3106	IN	denotes	in
T3024	3107-3125	JJ	denotes	immunoinflammatory
T3025	3126-3135	NNS	denotes	responses
T3026	3136-3140	VBD	denotes	were
T3027	3141-3155	RB	denotes	differentially
T3028	3166-3168	IN	denotes	in
T3029	3169-3172	DT	denotes	the
T3030	3179-3184	NNS	denotes	cells
T3031	3173-3178	NN	denotes	blood
T3032	3185-3187	IN	denotes	in
T3033	3188-3190	NN	denotes	RA
T3034	3191-3199	NNS	denotes	patients
T3035	3200-3201	-LRB-	denotes	[
T3036	3201-3203	CD	denotes	18
T3037	3203-3204	-RRB-	denotes	]
T3038	3204-3205	.	denotes	.
T3039	3205-3488	sentence	denotes	Chemokines and adhesion molecules were upregulated in the joint at the initiation phase of arthritis in animal models [21,22], while genes involved in cartilage destruction and bone erosion were differentially expressed at the late phase of arthritis in animal models of RA [15,16].
T3040	3206-3216	NNS	denotes	Chemokines
T3041	3245-3256	VBN	denotes	upregulated
T3042	3217-3220	CC	denotes	and
T3043	3221-3229	NN	denotes	adhesion
T3044	3230-3239	NNS	denotes	molecules
T3045	3240-3244	VBD	denotes	were
T3046	3257-3259	IN	denotes	in
T3047	3260-3263	DT	denotes	the
T3048	3264-3269	NN	denotes	joint
T3049	3270-3272	IN	denotes	at
T3050	3273-3276	DT	denotes	the
T3051	3288-3293	NN	denotes	phase
T3052	3277-3287	NN	denotes	initiation
T3053	3294-3296	IN	denotes	of
T3054	3297-3306	NN	denotes	arthritis
T3055	3307-3309	IN	denotes	in
T3056	3310-3316	NN	denotes	animal
T3057	3317-3323	NNS	denotes	models
T3058	3324-3325	-LRB-	denotes	[
T3059	3328-3330	CD	denotes	22
T3060	3325-3327	CD	denotes	21
T3061	3327-3328	,	denotes	,
T3062	3330-3331	-RRB-	denotes	]
T3063	3331-3333	,	denotes	,
T3064	3333-3338	IN	denotes	while
T3065	3416-3425	VBN	denotes	expressed
T3066	3339-3344	NNS	denotes	genes
T3067	3345-3353	VBN	denotes	involved
T3068	3354-3356	IN	denotes	in
T3069	3357-3366	NN	denotes	cartilage
T3070	3367-3378	NN	denotes	destruction
T3071	3379-3382	CC	denotes	and
T3072	3383-3387	NN	denotes	bone
T3073	3388-3395	NN	denotes	erosion
T3074	3396-3400	VBD	denotes	were
T3075	3401-3415	RB	denotes	differentially
T3076	3426-3428	IN	denotes	at
T3077	3429-3432	DT	denotes	the
T3078	3438-3443	NN	denotes	phase
T3079	3433-3437	JJ	denotes	late
T3080	3444-3446	IN	denotes	of
T3081	3447-3456	NN	denotes	arthritis
T3082	3457-3459	IN	denotes	in
T3083	3460-3466	NN	denotes	animal
T3084	3467-3473	NNS	denotes	models
T3085	3474-3476	IN	denotes	of
T3086	3477-3479	NN	denotes	RA
T3087	3480-3481	-LRB-	denotes	[
T3088	3484-3486	CD	denotes	16
T3089	3481-3483	CD	denotes	15
T3090	3483-3484	,	denotes	,
T3091	3486-3487	-RRB-	denotes	]
T3092	3487-3488	.	denotes	.
T3093	3488-3759	sentence	denotes	Besides detecting genes involved in complex diseases, microarrays could also be used to detect the genetic polymorphisms regulating gene expression because differential expressions between two strains might be the result of a polymorphism located in regulatory elements.
T3094	3489-3496	IN	denotes	Besides
T3095	3497-3506	VBG	denotes	detecting
T3096	3569-3573	VBN	denotes	used
T3097	3507-3512	NNS	denotes	genes
T3098	3513-3521	VBN	denotes	involved
T3099	3522-3524	IN	denotes	in
T3100	3525-3532	JJ	denotes	complex
T3101	3533-3541	NNS	denotes	diseases
T3102	3541-3543	,	denotes	,
T3103	3543-3554	NNS	denotes	microarrays
T3104	3555-3560	MD	denotes	could
T3105	3561-3565	RB	denotes	also
T3106	3566-3568	VB	denotes	be
T3107	3574-3576	TO	denotes	to
T3108	3577-3583	VB	denotes	detect
T3109	3584-3587	DT	denotes	the
T3110	3596-3609	NNS	denotes	polymorphisms
T3111	3588-3595	JJ	denotes	genetic
T3112	3610-3620	VBG	denotes	regulating
T3113	3621-3625	NN	denotes	gene
T3114	3626-3636	NN	denotes	expression
T3115	3637-3644	IN	denotes	because
T3116	3696-3698	VB	denotes	be
T3117	3645-3657	JJ	denotes	differential
T3118	3658-3669	NNS	denotes	expressions
T3119	3670-3677	IN	denotes	between
T3120	3678-3681	CD	denotes	two
T3121	3682-3689	NNS	denotes	strains
T3122	3690-3695	MD	denotes	might
T3123	3699-3702	DT	denotes	the
T3124	3703-3709	NN	denotes	result
T3125	3710-3712	IN	denotes	of
T3126	3713-3714	DT	denotes	a
T3127	3715-3727	NN	denotes	polymorphism
T3128	3728-3735	VBN	denotes	located
T3129	3736-3738	IN	denotes	in
T3130	3739-3749	JJ	denotes	regulatory
T3131	3750-3758	NNS	denotes	elements
T3132	3758-3759	.	denotes	.
T3133	3759-3964	sentence	denotes	To identify the small-effect QTL of CIA as well as the potential candidate genes inside them, we investigated CIA genetically susceptible and resistant strains at both the genome and transcriptome levels.
T3134	3760-3762	TO	denotes	To
T3135	3763-3771	VB	denotes	identify
T3136	3857-3869	VBD	denotes	investigated
T3137	3772-3775	DT	denotes	the
T3138	3789-3792	NN	denotes	QTL
T3139	3776-3781	JJ	denotes	small
T3140	3782-3788	NN	denotes	effect
T3141	3781-3782	HYPH	denotes	-
T3142	3793-3795	IN	denotes	of
T3143	3796-3799	NN	denotes	CIA
T3144	3800-3802	RB	denotes	as
T3145	3808-3810	IN	denotes	as
T3146	3803-3807	RB	denotes	well
T3147	3811-3814	DT	denotes	the
T3148	3835-3840	NNS	denotes	genes
T3149	3815-3824	JJ	denotes	potential
T3150	3825-3834	NN	denotes	candidate
T3151	3841-3847	IN	denotes	inside
T3152	3848-3852	PRP	denotes	them
T3153	3852-3854	,	denotes	,
T3154	3854-3856	PRP	denotes	we
T3155	3870-3873	NN	denotes	CIA
T3156	3886-3897	JJ	denotes	susceptible
T3157	3874-3885	RB	denotes	genetically
T3158	3912-3919	NNS	denotes	strains
T3159	3898-3901	CC	denotes	and
T3160	3902-3911	JJ	denotes	resistant
T3161	3920-3922	IN	denotes	at
T3162	3923-3927	CC	denotes	both
T3163	3932-3938	NN	denotes	genome
T3164	3928-3931	DT	denotes	the
T3165	3957-3963	NNS	denotes	levels
T3166	3939-3942	CC	denotes	and
T3167	3943-3956	NN	denotes	transcriptome
T3168	3963-3964	.	denotes	.
T3169	3964-4151	sentence	denotes	At the genome level, F2 progeny of the CIA susceptible (DBA/1) and resistant (FVB/N) strains were generated and a genome-wide linkage analysis was performed to identify small-effect QTL.
T3170	3965-3967	IN	denotes	At
T3171	4063-4072	VBN	denotes	generated
T3172	3968-3971	DT	denotes	the
T3173	3979-3984	NN	denotes	level
T3174	3972-3978	NN	denotes	genome
T3175	3984-3986	,	denotes	,
T3176	3986-3988	NN	denotes	F2
T3177	3989-3996	NN	denotes	progeny
T3178	3997-3999	IN	denotes	of
T3179	4000-4003	DT	denotes	the
T3180	4050-4057	NNS	denotes	strains
T3181	4004-4007	NN	denotes	CIA
T3182	4008-4019	JJ	denotes	susceptible
T3183	4020-4021	-LRB-	denotes	(
T3184	4021-4024	NN	denotes	DBA
T3185	4024-4025	HYPH	denotes	/
T3186	4025-4026	CD	denotes	1
T3187	4026-4027	-RRB-	denotes	)
T3188	4028-4031	CC	denotes	and
T3189	4032-4041	JJ	denotes	resistant
T3190	4042-4043	-LRB-	denotes	(
T3191	4047-4048	NN	denotes	N
T3192	4043-4046	NN	denotes	FVB
T3193	4046-4047	HYPH	denotes	/
T3194	4048-4049	-RRB-	denotes	)
T3195	4058-4062	VBD	denotes	were
T3196	4073-4076	CC	denotes	and
T3197	4077-4078	DT	denotes	a
T3198	4099-4107	NN	denotes	analysis
T3199	4079-4085	NN	denotes	genome
T3200	4086-4090	JJ	denotes	wide
T3201	4085-4086	HYPH	denotes	-
T3202	4091-4098	NN	denotes	linkage
T3203	4112-4121	VBN	denotes	performed
T3204	4108-4111	VBD	denotes	was
T3205	4122-4124	TO	denotes	to
T3206	4125-4133	VB	denotes	identify
T3207	4134-4139	JJ	denotes	small
T3208	4140-4146	NN	denotes	effect
T3209	4139-4140	HYPH	denotes	-
T3210	4147-4150	NN	denotes	QTL
T3211	4150-4151	.	denotes	.
T3212	4151-4289	sentence	denotes	At the transcriptome level, we detected the gene expression patterns of both the DBA/1 and FVB/N strains at four different phases of CIA.
T3213	4152-4154	IN	denotes	At
T3214	4183-4191	VBD	denotes	detected
T3215	4155-4158	DT	denotes	the
T3216	4173-4178	NN	denotes	level
T3217	4159-4172	NN	denotes	transcriptome
T3218	4178-4180	,	denotes	,
T3219	4180-4182	PRP	denotes	we
T3220	4192-4195	DT	denotes	the
T3221	4212-4220	NNS	denotes	patterns
T3222	4196-4200	NN	denotes	gene
T3223	4201-4211	NN	denotes	expression
T3224	4221-4223	IN	denotes	of
T3225	4224-4228	CC	denotes	both
T3226	4249-4256	NNS	denotes	strains
T3227	4229-4232	DT	denotes	the
T3228	4233-4236	NN	denotes	DBA
T3229	4236-4237	HYPH	denotes	/
T3230	4237-4238	CD	denotes	1
T3231	4239-4242	CC	denotes	and
T3232	4243-4246	NN	denotes	FVB
T3233	4247-4248	NN	denotes	N
T3234	4246-4247	HYPH	denotes	/
T3235	4257-4259	IN	denotes	at
T3236	4260-4264	CD	denotes	four
T3237	4275-4281	NNS	denotes	phases
T3238	4265-4274	JJ	denotes	different
T3239	4282-4284	IN	denotes	of
T3240	4285-4288	NN	denotes	CIA
T3241	4288-4289	.	denotes	.
T3242	4289-4580	sentence	denotes	The potential candidate genes were identified based on three criteria: they are located within the genomic region linked to CIA; they are disease-specific differentially expressed during CIA; and they are strain-specific differentially expressed between the two parental strains during CIA.
T3243	4290-4293	DT	denotes	The
T3244	4314-4319	NNS	denotes	genes
T3245	4294-4303	JJ	denotes	potential
T3246	4304-4313	NN	denotes	candidate
T3247	4325-4335	VBN	denotes	identified
T3248	4320-4324	VBD	denotes	were
T3249	4370-4377	VBN	denotes	located
T3250	4336-4341	VBN	denotes	based
T3251	4342-4344	IN	denotes	on
T3252	4345-4350	CD	denotes	three
T3253	4351-4359	NNS	denotes	criteria
T3254	4359-4361	:	denotes	:
T3255	4361-4365	PRP	denotes	they
T3256	4366-4369	VBP	denotes	are
T3257	4378-4384	IN	denotes	within
T3258	4385-4388	DT	denotes	the
T3259	4397-4403	NN	denotes	region
T3260	4389-4396	JJ	denotes	genomic
T3261	4404-4410	VBN	denotes	linked
T3262	4411-4413	IN	denotes	to
T3263	4414-4417	NN	denotes	CIA
T3264	4417-4418	:	denotes	;
T3265	4419-4423	PRP	denotes	they
T3266	4460-4469	VBN	denotes	expressed
T3267	4424-4427	VBP	denotes	are
T3268	4428-4435	NN	denotes	disease
T3269	4436-4444	RB	denotes	specific
T3270	4435-4436	HYPH	denotes	-
T3271	4445-4459	RB	denotes	differentially
T3272	4470-4476	IN	denotes	during
T3273	4477-4480	NN	denotes	CIA
T3274	4480-4481	:	denotes	;
T3275	4482-4485	CC	denotes	and
T3276	4486-4490	PRP	denotes	they
T3277	4526-4535	VBN	denotes	expressed
T3278	4491-4494	VBP	denotes	are
T3279	4495-4501	NN	denotes	strain
T3280	4502-4510	RB	denotes	specific
T3281	4501-4502	HYPH	denotes	-
T3282	4511-4525	RB	denotes	differentially
T3283	4536-4543	IN	denotes	between
T3284	4544-4547	DT	denotes	the
T3285	4561-4568	NNS	denotes	strains
T3286	4548-4551	CD	denotes	two
T3287	4552-4560	JJ	denotes	parental
T3288	4569-4575	IN	denotes	during
T3289	4576-4579	NN	denotes	CIA
T3290	4579-4580	.	denotes	.
T4075	4775-4786	NN	denotes	environment
T4076	4756-4763	NN	denotes	climate
T4077	4764-4774	VBN	denotes	controlled
T4078	4763-4764	HYPH	denotes	-
T4079	4787-4791	IN	denotes	with
T4080	4792-4794	CD	denotes	12
T4044	4605-4612	NNS	denotes	Animals
T4045	4612-4614	,	denotes	,
T4046	4614-4626	NN	denotes	immunisation
T4047	4627-4630	CC	denotes	and
T4048	4631-4641	NN	denotes	assessment
T4049	4642-4644	IN	denotes	of
T4050	4645-4654	NN	denotes	arthritis
T4051	4654-4870	sentence	denotes	Both DBA/1 and FVB/N mice used in this study were obtained from the Jackson Laboratory and kept in a climate-controlled environment with 12 hour light/dark cycles in the animal facility at the University of Rostock.
T4052	4655-4659	CC	denotes	Both
T4053	4660-4663	NN	denotes	DBA
T4054	4676-4680	NNS	denotes	mice
T4055	4663-4664	HYPH	denotes	/
T4056	4664-4665	CD	denotes	1
T4057	4666-4669	CC	denotes	and
T4058	4670-4673	NN	denotes	FVB
T4059	4674-4675	NN	denotes	N
T4060	4673-4674	HYPH	denotes	/
T4061	4705-4713	VBN	denotes	obtained
T4062	4681-4685	VBN	denotes	used
T4063	4686-4688	IN	denotes	in
T4064	4689-4693	DT	denotes	this
T4065	4694-4699	NN	denotes	study
T4066	4700-4704	VBD	denotes	were
T4067	4714-4718	IN	denotes	from
T4068	4719-4722	DT	denotes	the
T4069	4731-4741	NNP	denotes	Laboratory
T4070	4723-4730	NNP	denotes	Jackson
T4071	4742-4745	CC	denotes	and
T4072	4746-4750	VBN	denotes	kept
T4073	4751-4753	IN	denotes	in
T4074	4754-4755	DT	denotes	a
T4081	4795-4799	NN	denotes	hour
T4082	4811-4817	NNS	denotes	cycles
T4083	4800-4805	NN	denotes	light
T4084	4806-4810	NN	denotes	dark
T4085	4805-4806	HYPH	denotes	/
T4086	4818-4820	IN	denotes	in
T4087	4821-4824	DT	denotes	the
T4088	4832-4840	NN	denotes	facility
T4089	4825-4831	NN	denotes	animal
T4090	4841-4843	IN	denotes	at
T4091	4844-4847	DT	denotes	the
T4092	4848-4858	NNP	denotes	University
T4093	4859-4861	IN	denotes	of
T4094	4862-4869	NNP	denotes	Rostock
T4095	4869-4870	.	denotes	.
T4096	4870-4947	sentence	denotes	All animal experiments were pre-approved by the State Animal Care Committee.
T4097	4871-4874	DT	denotes	All
T4098	4882-4893	NNS	denotes	experiments
T4099	4875-4881	NN	denotes	animal
T4100	4899-4911	VBN	denotes	pre-approved
T4101	4894-4898	VBD	denotes	were
T4102	4912-4914	IN	denotes	by
T4103	4915-4918	DT	denotes	the
T4104	4937-4946	NNP	denotes	Committee
T4105	4919-4924	NNP	denotes	State
T4106	4925-4931	NNP	denotes	Animal
T4107	4932-4936	NNP	denotes	Care
T4108	4946-4947	.	denotes	.
T4109	4947-5061	sentence	denotes	CIA was induced in control and experimental animals according to established protocols described previously [10].
T4110	4948-4951	NN	denotes	CIA
T4111	4956-4963	VBN	denotes	induced
T4112	4952-4955	VBD	denotes	was
T4113	4964-4966	IN	denotes	in
T4114	4967-4974	NN	denotes	control
T4115	4992-4999	NNS	denotes	animals
T4116	4975-4978	CC	denotes	and
T4117	4979-4991	JJ	denotes	experimental
T4118	5000-5009	VBG	denotes	according
T4119	5010-5012	IN	denotes	to
T4120	5013-5024	VBN	denotes	established
T4121	5025-5034	NNS	denotes	protocols
T4122	5035-5044	VBN	denotes	described
T4123	5045-5055	RB	denotes	previously
T4124	5056-5057	-LRB-	denotes	[
T4125	5057-5059	CD	denotes	10
T4126	5059-5060	-RRB-	denotes	]
T4127	5060-5061	.	denotes	.
T4128	5061-5280	sentence	denotes	In brief, DBA/1J, FVB/N and (DBA/1J × FVB/N)F2 progeny were immunised at 8 to 12 weeks at the base of the tail with 125 μg of bovine Collagen II (Chondrex, Redmond, WA, USA) emulsified in CFA (DIFCO, Detroit, MI, USA).
T4129	5062-5064	IN	denotes	In
T4130	5122-5131	VBN	denotes	immunised
T4131	5065-5070	NN	denotes	brief
T4132	5070-5072	,	denotes	,
T4133	5072-5075	NN	denotes	DBA
T4134	5076-5078	NN	denotes	1J
T4135	5075-5076	HYPH	denotes	/
T4136	5109-5116	NN	denotes	progeny
T4137	5078-5080	,	denotes	,
T4138	5080-5083	NN	denotes	FVB
T4139	5084-5085	NN	denotes	N
T4140	5083-5084	HYPH	denotes	/
T4141	5086-5089	CC	denotes	and
T4142	5090-5091	-LRB-	denotes	(
T4143	5095-5097	NN	denotes	1J
T4144	5091-5094	NN	denotes	DBA
T4145	5094-5095	HYPH	denotes	/
T4146	5098-5099	SYM	denotes	×
T4147	5100-5103	NN	denotes	FVB
T4148	5104-5105	NN	denotes	N
T4149	5103-5104	HYPH	denotes	/
T4150	5105-5106	-RRB-	denotes	)
T4151	5106-5108	NN	denotes	F2
T4152	5117-5121	VBD	denotes	were
T4153	5132-5134	IN	denotes	at
T4154	5135-5136	CD	denotes	8
T4155	5140-5142	CD	denotes	12
T4156	5137-5139	IN	denotes	to
T4157	5143-5148	NNS	denotes	weeks
T4158	5149-5151	IN	denotes	at
T4159	5152-5155	DT	denotes	the
T4160	5156-5160	NN	denotes	base
T4161	5161-5163	IN	denotes	of
T4162	5164-5167	DT	denotes	the
T4163	5168-5172	NN	denotes	tail
T4164	5173-5177	IN	denotes	with
T4165	5178-5181	CD	denotes	125
T4166	5182-5184	NN	denotes	μg
T4167	5185-5187	IN	denotes	of
T4168	5188-5194	JJ	denotes	bovine
T4169	5195-5203	NN	denotes	Collagen
T4170	5204-5206	CD	denotes	II
T4171	5207-5208	-LRB-	denotes	(
T4172	5208-5216	NNP	denotes	Chondrex
T4173	5216-5218	,	denotes	,
T4174	5218-5225	NNP	denotes	Redmond
T4175	5225-5227	,	denotes	,
T4176	5227-5229	NNP	denotes	WA
T4177	5229-5231	,	denotes	,
T4178	5231-5234	NNP	denotes	USA
T4179	5234-5235	-RRB-	denotes	)
T4180	5236-5246	VBN	denotes	emulsified
T4181	5247-5249	IN	denotes	in
T4182	5250-5253	NN	denotes	CFA
T4183	5254-5255	-LRB-	denotes	(
T4184	5255-5260	NNP	denotes	DIFCO
T4185	5260-5262	,	denotes	,
T4186	5262-5269	NNP	denotes	Detroit
T4187	5269-5271	,	denotes	,
T4188	5271-5273	NNP	denotes	MI
T4189	5273-5275	,	denotes	,
T4190	5275-5278	NNP	denotes	USA
T4191	5278-5279	-RRB-	denotes	)
T4192	5279-5280	.	denotes	.
T4193	5280-5416	sentence	denotes	The clinical scoring of arthritis commenced 18 days after immunisation, and animals were monitored three times weekly for signs of CIA.
T4194	5281-5284	DT	denotes	The
T4195	5294-5301	NN	denotes	scoring
T4196	5285-5293	JJ	denotes	clinical
T4197	5315-5324	VBD	denotes	commenced
T4198	5302-5304	IN	denotes	of
T4199	5305-5314	NN	denotes	arthritis
T4200	5325-5327	CD	denotes	18
T4201	5328-5332	NNS	denotes	days
T4202	5333-5338	IN	denotes	after
T4203	5339-5351	NN	denotes	immunisation
T4204	5351-5353	,	denotes	,
T4205	5353-5356	CC	denotes	and
T4206	5357-5364	NNS	denotes	animals
T4207	5370-5379	VBN	denotes	monitored
T4208	5365-5369	VBD	denotes	were
T4209	5380-5385	CD	denotes	three
T4210	5386-5391	NNS	denotes	times
T4211	5392-5398	RB	denotes	weekly
T4212	5399-5402	IN	denotes	for
T4213	5403-5408	NNS	denotes	signs
T4214	5409-5411	IN	denotes	of
T4215	5412-5415	NN	denotes	CIA
T4216	5415-5416	.	denotes	.
T4217	5416-5536	sentence	denotes	Arthritis development was monitored in all four limbs using a three-score system per limb as described previously [10].
T4218	5417-5426	NN	denotes	Arthritis
T4219	5427-5438	NN	denotes	development
T4220	5443-5452	VBN	denotes	monitored
T4221	5439-5442	VBD	denotes	was
T4222	5453-5455	IN	denotes	in
T4223	5456-5459	DT	denotes	all
T4224	5465-5470	NNS	denotes	limbs
T4225	5460-5464	CD	denotes	four
T4226	5471-5476	VBG	denotes	using
T4227	5477-5478	DT	denotes	a
T4228	5491-5497	NN	denotes	system
T4229	5479-5484	CD	denotes	three
T4230	5485-5490	NN	denotes	score
T4231	5484-5485	HYPH	denotes	-
T4232	5498-5501	IN	denotes	per
T4233	5502-5506	NN	denotes	limb
T4234	5507-5509	IN	denotes	as
T4235	5510-5519	VBN	denotes	described
T4236	5520-5530	RB	denotes	previously
T4237	5531-5532	-LRB-	denotes	[
T4238	5532-5534	CD	denotes	10
T4239	5534-5535	-RRB-	denotes	]
T4240	5535-5536	.	denotes	.
T4241	5536-5621	sentence	denotes	Eight-week old FVB/N and DBA/1J mice were used for the detection of gene expression.
T4242	5537-5542	CD	denotes	Eight
T4243	5543-5547	NN	denotes	week
T4244	5542-5543	HYPH	denotes	-
T4245	5548-5551	JJ	denotes	old
T4246	5569-5573	NNS	denotes	mice
T4247	5552-5555	NN	denotes	FVB
T4248	5556-5557	NN	denotes	N
T4249	5555-5556	HYPH	denotes	/
T4250	5558-5561	CC	denotes	and
T4251	5562-5565	NN	denotes	DBA
T4252	5566-5568	NN	denotes	1J
T4253	5565-5566	HYPH	denotes	/
T4254	5579-5583	VBN	denotes	used
T4255	5574-5578	VBD	denotes	were
T4256	5584-5587	IN	denotes	for
T4257	5588-5591	DT	denotes	the
T4258	5592-5601	NN	denotes	detection
T4259	5602-5604	IN	denotes	of
T4260	5605-5609	NN	denotes	gene
T4261	5610-5620	NN	denotes	expression
T4262	5620-5621	.	denotes	.
T4263	5621-5824	sentence	denotes	They were divided into four experimental groups according to the different phases of CIA, namely naive control (NC), post-immunisation (PI), onset of arthritis (OA) and chronic arthritis (CA) (Table 1).
T4264	5622-5626	PRP	denotes	They
T4265	5632-5639	VBN	denotes	divided
T4266	5627-5631	VBD	denotes	were
T4267	5640-5644	IN	denotes	into
T4268	5645-5649	CD	denotes	four
T4269	5663-5669	NNS	denotes	groups
T4270	5650-5662	JJ	denotes	experimental
T4271	5670-5679	VBG	denotes	according
T4272	5680-5682	IN	denotes	to
T4273	5683-5686	DT	denotes	the
T4274	5697-5703	NNS	denotes	phases
T4275	5687-5696	JJ	denotes	different
T4276	5704-5706	IN	denotes	of
T4277	5707-5710	NN	denotes	CIA
T4278	5710-5712	,	denotes	,
T4279	5712-5718	RB	denotes	namely
T4280	5725-5732	NN	denotes	control
T4281	5719-5724	JJ	denotes	naive
T4282	5733-5734	-LRB-	denotes	(
T4283	5734-5736	NN	denotes	NC
T4284	5736-5737	-RRB-	denotes	)
T4285	5737-5739	,	denotes	,
T4286	5739-5756	NN	denotes	post-immunisation
T4287	5757-5758	-LRB-	denotes	(
T4288	5758-5760	NN	denotes	PI
T4289	5760-5761	-RRB-	denotes	)
T4290	5761-5763	,	denotes	,
T4291	5763-5768	NN	denotes	onset
T4292	5769-5771	IN	denotes	of
T4293	5772-5781	NN	denotes	arthritis
T4294	5782-5783	-LRB-	denotes	(
T4295	5783-5785	NN	denotes	OA
T4296	5785-5786	-RRB-	denotes	)
T4297	5787-5790	CC	denotes	and
T4298	5791-5798	JJ	denotes	chronic
T4299	5799-5808	NN	denotes	arthritis
T4300	5809-5810	-LRB-	denotes	(
T4301	5810-5812	NN	denotes	CA
T4302	5812-5813	-RRB-	denotes	)
T4303	5814-5815	-LRB-	denotes	(
T4304	5815-5820	NN	denotes	Table
T4305	5821-5822	CD	denotes	1
T4306	5822-5823	-RRB-	denotes	)
T4307	5823-5824	.	denotes	.
T4308	5824-5910	sentence	denotes	The NC group contained non-immunised mice that were sacrificed at the age of 8 weeks.
T4309	5825-5828	DT	denotes	The
T4310	5832-5837	NN	denotes	group
T4311	5829-5831	NN	denotes	NC
T4312	5838-5847	VBD	denotes	contained
T4313	5848-5861	JJ	denotes	non-immunised
T4314	5862-5866	NNS	denotes	mice
T4315	5867-5871	WDT	denotes	that
T4316	5877-5887	VBN	denotes	sacrificed
T4317	5872-5876	VBD	denotes	were
T4318	5888-5890	IN	denotes	at
T4319	5891-5894	DT	denotes	the
T4320	5895-5898	NN	denotes	age
T4321	5899-5901	IN	denotes	of
T4322	5902-5903	CD	denotes	8
T4323	5904-5909	NNS	denotes	weeks
T4324	5909-5910	.	denotes	.
T4325	5910-5981	sentence	denotes	The mice in the PI group were sacrificed on day 10 after immunisation.
T4326	5911-5914	DT	denotes	The
T4327	5915-5919	NNS	denotes	mice
T4328	5941-5951	VBN	denotes	sacrificed
T4329	5920-5922	IN	denotes	in
T4330	5923-5926	DT	denotes	the
T4331	5930-5935	NN	denotes	group
T4332	5927-5929	NN	denotes	PI
T4333	5936-5940	VBD	denotes	were
T4334	5952-5954	IN	denotes	on
T4335	5955-5958	NN	denotes	day
T4336	5959-5961	CD	denotes	10
T4337	5962-5967	IN	denotes	after
T4338	5968-5980	NN	denotes	immunisation
T4339	5980-5981	.	denotes	.
T4340	5981-6052	sentence	denotes	The mice in the OA group were sacrificed on day 35 after immunisation.
T4341	5982-5985	DT	denotes	The
T4342	5986-5990	NNS	denotes	mice
T4343	6012-6022	VBN	denotes	sacrificed
T4344	5991-5993	IN	denotes	in
T4345	5994-5997	DT	denotes	the
T4346	6001-6006	NN	denotes	group
T4347	5998-6000	NN	denotes	OA
T4348	6007-6011	VBD	denotes	were
T4349	6023-6025	IN	denotes	on
T4350	6026-6029	NN	denotes	day
T4351	6030-6032	CD	denotes	35
T4352	6033-6038	IN	denotes	after
T4353	6039-6051	NN	denotes	immunisation
T4354	6051-6052	.	denotes	.
T4355	6052-6216	sentence	denotes	Three FVB/N non-arthritic mice and three DBA/1 mice that showed signs of arthritis on day 33 or 34 after immunisation were sacrificed on day 35 after immunisation.
T4356	6053-6058	CD	denotes	Three
T4357	6079-6083	NNS	denotes	mice
T4358	6059-6062	NN	denotes	FVB
T4359	6063-6064	NN	denotes	N
T4360	6062-6063	HYPH	denotes	/
T4361	6065-6078	JJ	denotes	non-arthritic
T4362	6176-6186	VBN	denotes	sacrificed
T4363	6084-6087	CC	denotes	and
T4364	6088-6093	CD	denotes	three
T4365	6100-6104	NNS	denotes	mice
T4366	6094-6097	NN	denotes	DBA
T4367	6097-6098	HYPH	denotes	/
T4368	6098-6099	CD	denotes	1
T4369	6105-6109	WDT	denotes	that
T4370	6110-6116	VBD	denotes	showed
T4371	6117-6122	NNS	denotes	signs
T4372	6123-6125	IN	denotes	of
T4373	6126-6135	NN	denotes	arthritis
T4374	6136-6138	IN	denotes	on
T4375	6139-6142	NN	denotes	day
T4376	6143-6145	CD	denotes	33
T4377	6146-6148	CC	denotes	or
T4378	6149-6151	CD	denotes	34
T4379	6152-6157	IN	denotes	after
T4380	6158-6170	NN	denotes	immunisation
T4381	6171-6175	VBD	denotes	were
T4382	6187-6189	IN	denotes	on
T4383	6190-6193	NN	denotes	day
T4384	6194-6196	CD	denotes	35
T4385	6197-6202	IN	denotes	after
T4386	6203-6215	NN	denotes	immunisation
T4387	6215-6216	.	denotes	.
T4388	6216-6287	sentence	denotes	The mice in the CA group were sacrificed on day 95 after immunisation.
T4389	6217-6220	DT	denotes	The
T4390	6221-6225	NNS	denotes	mice
T4391	6247-6257	VBN	denotes	sacrificed
T4392	6226-6228	IN	denotes	in
T4393	6229-6232	DT	denotes	the
T4394	6236-6241	NN	denotes	group
T4395	6233-6235	NN	denotes	CA
T4396	6242-6246	VBD	denotes	were
T4397	6258-6260	IN	denotes	on
T4398	6261-6264	NN	denotes	day
T4399	6265-6267	CD	denotes	95
T4400	6268-6273	IN	denotes	after
T4401	6274-6286	NN	denotes	immunisation
T4402	6286-6287	.	denotes	.
T4403	6287-6438	sentence	denotes	Three non-arthritic FVB/N mice and three DBA/1 mice that had developed arthritis for at least two months were sacrificed on day 95 after immunisation.
T4404	6288-6293	CD	denotes	Three
T4405	6314-6318	NNS	denotes	mice
T4406	6294-6307	JJ	denotes	non-arthritic
T4407	6308-6311	NN	denotes	FVB
T4408	6312-6313	NN	denotes	N
T4409	6311-6312	HYPH	denotes	/
T4410	6398-6408	VBN	denotes	sacrificed
T4411	6319-6322	CC	denotes	and
T4412	6323-6328	CD	denotes	three
T4413	6335-6339	NNS	denotes	mice
T4414	6329-6332	NN	denotes	DBA
T4415	6332-6333	HYPH	denotes	/
T4416	6333-6334	CD	denotes	1
T4417	6340-6344	WDT	denotes	that
T4418	6349-6358	VBN	denotes	developed
T4419	6345-6348	VBD	denotes	had
T4420	6359-6368	NN	denotes	arthritis
T4421	6369-6372	IN	denotes	for
T4422	6373-6375	RB	denotes	at
T4423	6382-6385	CD	denotes	two
T4424	6376-6381	RBS	denotes	least
T4425	6386-6392	NNS	denotes	months
T4426	6393-6397	VBD	denotes	were
T4427	6409-6411	IN	denotes	on
T4428	6412-6415	NN	denotes	day
T4429	6416-6418	CD	denotes	95
T4430	6419-6424	IN	denotes	after
T4431	6425-6437	NN	denotes	immunisation
T4432	6437-6438	.	denotes	.
T4689	6785-6787	CD	denotes	23
T4628	6440-6447	NN	denotes	Linkage
T4629	6448-6456	NN	denotes	analysis
T4630	6456-6548	sentence	denotes	Detailed information on genotyping of the genome screen has been described previously [10].
T4631	6457-6465	JJ	denotes	Detailed
T4632	6466-6477	NN	denotes	information
T4633	6522-6531	VBN	denotes	described
T4634	6478-6480	IN	denotes	on
T4635	6481-6491	NN	denotes	genotyping
T4636	6492-6494	IN	denotes	of
T4637	6495-6498	DT	denotes	the
T4638	6506-6512	NN	denotes	screen
T4639	6499-6505	NN	denotes	genome
T4640	6513-6516	VBZ	denotes	has
T4641	6517-6521	VBN	denotes	been
T4642	6532-6542	RB	denotes	previously
T4643	6543-6544	-LRB-	denotes	[
T4644	6544-6546	CD	denotes	10
T4645	6546-6547	-RRB-	denotes	]
T4646	6547-6548	.	denotes	.
T4647	6548-6717	sentence	denotes	In short, we genotyped 290 F2 mice using 126 informative microsatellite markers covering the genome with an average inter-marker distance of 11.5 cM for 290 F2 progeny.
T4648	6549-6551	IN	denotes	In
T4649	6562-6571	VBD	denotes	genotyped
T4650	6552-6557	JJ	denotes	short
T4651	6557-6559	,	denotes	,
T4652	6559-6561	PRP	denotes	we
T4653	6572-6575	CD	denotes	290
T4654	6579-6583	NNS	denotes	mice
T4655	6576-6578	NN	denotes	F2
T4656	6584-6589	VBG	denotes	using
T4657	6590-6593	CD	denotes	126
T4658	6621-6628	NNS	denotes	markers
T4659	6594-6605	JJ	denotes	informative
T4660	6606-6620	NN	denotes	microsatellite
T4661	6629-6637	VBG	denotes	covering
T4662	6638-6641	DT	denotes	the
T4663	6642-6648	NN	denotes	genome
T4664	6649-6653	IN	denotes	with
T4665	6654-6656	DT	denotes	an
T4666	6678-6686	NN	denotes	distance
T4667	6657-6664	JJ	denotes	average
T4668	6665-6677	JJ	denotes	inter-marker
T4669	6687-6689	IN	denotes	of
T4670	6690-6694	CD	denotes	11.5
T4671	6695-6697	NN	denotes	cM
T4672	6698-6701	IN	denotes	for
T4673	6702-6705	CD	denotes	290
T4674	6709-6716	NN	denotes	progeny
T4675	6706-6708	NN	denotes	F2
T4676	6716-6717	.	denotes	.
T4677	6717-6789	sentence	denotes	All linkage analyses were performed with QTX Map manager software [23].
T4678	6718-6721	DT	denotes	All
T4679	6730-6738	NNS	denotes	analyses
T4680	6722-6729	NN	denotes	linkage
T4681	6744-6753	VBN	denotes	performed
T4682	6739-6743	VBD	denotes	were
T4683	6754-6758	IN	denotes	with
T4684	6759-6762	NN	denotes	QTX
T4685	6775-6783	NN	denotes	software
T4686	6763-6766	NN	denotes	Map
T4687	6767-6774	NN	denotes	manager
T4688	6784-6785	-LRB-	denotes	[
T4690	6787-6788	-RRB-	denotes	]
T4691	6788-6789	.	denotes	.
T4692	6789-6869	sentence	denotes	The main clinical phenotype of CIA, arthritis severity, was taken as phenotype.
T4693	6790-6793	DT	denotes	The
T4694	6808-6817	NN	denotes	phenotype
T4695	6794-6798	JJ	denotes	main
T4696	6799-6807	JJ	denotes	clinical
T4697	6850-6855	VBN	denotes	taken
T4698	6818-6820	IN	denotes	of
T4699	6821-6824	NN	denotes	CIA
T4700	6824-6826	,	denotes	,
T4701	6826-6835	NN	denotes	arthritis
T4702	6836-6844	NN	denotes	severity
T4703	6844-6846	,	denotes	,
T4704	6846-6849	VBD	denotes	was
T4705	6856-6858	IN	denotes	as
T4706	6859-6868	NN	denotes	phenotype
T4707	6868-6869	.	denotes	.
T4708	6869-6971	sentence	denotes	To detect the small-effect QTL, the threshold value of linkage was set as P = 0.05 (Chi-square test).
T4709	6870-6872	TO	denotes	To
T4710	6873-6879	VB	denotes	detect
T4711	6937-6940	VBN	denotes	set
T4712	6880-6883	DT	denotes	the
T4713	6897-6900	NN	denotes	QTL
T4714	6884-6889	JJ	denotes	small
T4715	6890-6896	NN	denotes	effect
T4716	6889-6890	HYPH	denotes	-
T4717	6900-6902	,	denotes	,
T4718	6902-6905	DT	denotes	the
T4719	6916-6921	NN	denotes	value
T4720	6906-6915	NN	denotes	threshold
T4721	6922-6924	IN	denotes	of
T4722	6925-6932	NN	denotes	linkage
T4723	6933-6936	VBD	denotes	was
T4724	6941-6943	IN	denotes	as
T4725	6944-6945	NN	denotes	P
T4726	6948-6952	CD	denotes	0.05
T4727	6946-6947	SYM	denotes	=
T4728	6953-6954	-LRB-	denotes	(
T4729	6965-6969	NN	denotes	test
T4730	6954-6957	NN	denotes	Chi
T4731	6958-6964	NN	denotes	square
T4732	6957-6958	HYPH	denotes	-
T4733	6969-6970	-RRB-	denotes	)
T4734	6970-6971	.	denotes	.
T5000	6973-6979	NN	denotes	Sample
T5001	6980-6991	NN	denotes	preparation
T5002	6992-6995	CC	denotes	and
T5003	6996-7006	NN	denotes	microarray
T5004	7007-7020	NN	denotes	hybridisation
T5005	7020-7106	sentence	denotes	Lymph nodes (LNs) draining the immunisation site were used for total RNA preparation.
T5006	7021-7026	NN	denotes	Lymph
T5007	7027-7032	NNS	denotes	nodes
T5008	7075-7079	VBN	denotes	used
T5009	7033-7034	-LRB-	denotes	(
T5010	7034-7037	NNS	denotes	LNs
T5011	7037-7038	-RRB-	denotes	)
T5012	7039-7047	VBG	denotes	draining
T5013	7048-7051	DT	denotes	the
T5014	7065-7069	NN	denotes	site
T5015	7052-7064	NN	denotes	immunisation
T5016	7070-7074	VBD	denotes	were
T5017	7080-7083	IN	denotes	for
T5018	7084-7089	JJ	denotes	total
T5019	7094-7105	NN	denotes	preparation
T5020	7090-7093	NN	denotes	RNA
T5021	7105-7106	.	denotes	.
T5022	7106-7252	sentence	denotes	The total RNA was extracted from the tissue homogenates using a commercial kit in accordance with the provided protocol (QIGEN, Hilden, Germany).
T5023	7107-7110	DT	denotes	The
T5024	7117-7120	NN	denotes	RNA
T5025	7111-7116	JJ	denotes	total
T5026	7125-7134	VBN	denotes	extracted
T5027	7121-7124	VBD	denotes	was
T5028	7135-7139	IN	denotes	from
T5029	7140-7143	DT	denotes	the
T5030	7151-7162	NNS	denotes	homogenates
T5031	7144-7150	NN	denotes	tissue
T5032	7163-7168	VBG	denotes	using
T5033	7169-7170	DT	denotes	a
T5034	7182-7185	NN	denotes	kit
T5035	7171-7181	JJ	denotes	commercial
T5036	7186-7188	IN	denotes	in
T5037	7189-7199	NN	denotes	accordance
T5038	7200-7204	IN	denotes	with
T5039	7205-7208	DT	denotes	the
T5040	7218-7226	NN	denotes	protocol
T5041	7209-7217	VBN	denotes	provided
T5042	7227-7228	-LRB-	denotes	(
T5043	7228-7233	NNP	denotes	QIGEN
T5044	7233-7235	,	denotes	,
T5045	7235-7241	NNP	denotes	Hilden
T5046	7241-7243	,	denotes	,
T5047	7243-7250	NNP	denotes	Germany
T5048	7250-7251	-RRB-	denotes	)
T5049	7251-7252	.	denotes	.
T5050	7252-7387	sentence	denotes	Analysis of gene expression was conducted using a U430A array (Affymetrix, Santa Clara, CA, USA) interrogating more than 22,000 genes.
T5051	7253-7261	NN	denotes	Analysis
T5052	7285-7294	VBN	denotes	conducted
T5053	7262-7264	IN	denotes	of
T5054	7265-7269	NN	denotes	gene
T5055	7270-7280	NN	denotes	expression
T5056	7281-7284	VBD	denotes	was
T5057	7295-7300	VBG	denotes	using
T5058	7301-7302	DT	denotes	a
T5059	7309-7314	NN	denotes	array
T5060	7303-7308	NN	denotes	U430A
T5061	7315-7316	-LRB-	denotes	(
T5062	7316-7326	NNP	denotes	Affymetrix
T5063	7326-7328	,	denotes	,
T5064	7328-7333	NNP	denotes	Santa
T5065	7334-7339	NNP	denotes	Clara
T5066	7339-7341	,	denotes	,
T5067	7341-7343	NNP	denotes	CA
T5068	7343-7345	,	denotes	,
T5069	7345-7348	NNP	denotes	USA
T5070	7348-7349	-RRB-	denotes	)
T5071	7350-7363	VBG	denotes	interrogating
T5072	7364-7368	JJR	denotes	more
T5073	7374-7380	CD	denotes	22,000
T5074	7369-7373	IN	denotes	than
T5075	7381-7386	NNS	denotes	genes
T5076	7386-7387	.	denotes	.
T5077	7387-7464	sentence	denotes	RNA probes were labelled in accordance with the manufacturer's instructions.
T5078	7388-7391	NN	denotes	RNA
T5079	7392-7398	NNS	denotes	probes
T5080	7404-7412	VBN	denotes	labelled
T5081	7399-7403	VBD	denotes	were
T5082	7413-7415	IN	denotes	in
T5083	7416-7426	NN	denotes	accordance
T5084	7427-7431	IN	denotes	with
T5085	7432-7435	DT	denotes	the
T5086	7436-7448	NN	denotes	manufacturer
T5087	7451-7463	NNS	denotes	instructions
T5088	7448-7450	POS	denotes	's
T5089	7463-7464	.	denotes	.
T5090	7464-7533	sentence	denotes	Samples from individual mice were hybridised onto individual arrays.
T5091	7465-7472	NNS	denotes	Samples
T5092	7499-7509	VBN	denotes	hybridised
T5093	7473-7477	IN	denotes	from
T5094	7478-7488	JJ	denotes	individual
T5095	7489-7493	NNS	denotes	mice
T5096	7494-7498	VBD	denotes	were
T5097	7510-7514	IN	denotes	onto
T5098	7515-7525	JJ	denotes	individual
T5099	7526-7532	NNS	denotes	arrays
T5100	7532-7533	.	denotes	.
T5101	7533-7613	sentence	denotes	Hybridisation and washing of gene chips were done as previously described [16].
T5102	7534-7547	NN	denotes	Hybridisation
T5103	7579-7583	VBN	denotes	done
T5104	7548-7551	CC	denotes	and
T5105	7552-7559	NN	denotes	washing
T5106	7560-7562	IN	denotes	of
T5107	7563-7567	NN	denotes	gene
T5108	7568-7573	NNS	denotes	chips
T5109	7574-7578	VBD	denotes	were
T5110	7584-7586	IN	denotes	as
T5111	7598-7607	VBN	denotes	described
T5112	7587-7597	RB	denotes	previously
T5113	7608-7609	-LRB-	denotes	[
T5114	7609-7611	CD	denotes	16
T5115	7611-7612	-RRB-	denotes	]
T5116	7612-7613	.	denotes	.
T5117	7613-7694	sentence	denotes	Fluorescent signals were collected by laser scan (Hewlett-Packard Gene Scanner).
T5118	7614-7625	JJ	denotes	Fluorescent
T5119	7626-7633	NNS	denotes	signals
T5120	7639-7648	VBN	denotes	collected
T5121	7634-7638	VBD	denotes	were
T5122	7649-7651	IN	denotes	by
T5123	7652-7657	NN	denotes	laser
T5124	7658-7662	NN	denotes	scan
T5125	7663-7664	-LRB-	denotes	(
T5126	7685-7692	NNP	denotes	Scanner
T5127	7664-7671	NNP	denotes	Hewlett
T5128	7672-7679	NNP	denotes	Packard
T5129	7671-7672	HYPH	denotes	-
T5130	7680-7684	NNP	denotes	Gene
T5131	7692-7693	-RRB-	denotes	)
T5132	7693-7694	.	denotes	.
T5603	7696-7706	NN	denotes	Microarray
T5604	7707-7715	NN	denotes	analysis
T5605	7715-7875	sentence	denotes	Normalisation of the expression level was done using Affymetrix software MAS 5, which is based on global scaling of total gene expression level per microarray.
T5606	7716-7729	NN	denotes	Normalisation
T5607	7758-7762	VBN	denotes	done
T5608	7730-7732	IN	denotes	of
T5609	7733-7736	DT	denotes	the
T5610	7748-7753	NN	denotes	level
T5611	7737-7747	NN	denotes	expression
T5612	7754-7757	VBD	denotes	was
T5613	7763-7768	VBG	denotes	using
T5614	7769-7779	NNP	denotes	Affymetrix
T5615	7789-7792	NN	denotes	MAS
T5616	7780-7788	NN	denotes	software
T5617	7793-7794	CD	denotes	5
T5618	7794-7796	,	denotes	,
T5619	7796-7801	WDT	denotes	which
T5620	7805-7810	VBN	denotes	based
T5621	7802-7804	VBZ	denotes	is
T5622	7811-7813	IN	denotes	on
T5623	7814-7820	JJ	denotes	global
T5624	7821-7828	NN	denotes	scaling
T5625	7829-7831	IN	denotes	of
T5626	7832-7837	JJ	denotes	total
T5627	7854-7859	NN	denotes	level
T5628	7838-7842	NN	denotes	gene
T5629	7843-7853	NN	denotes	expression
T5630	7860-7863	IN	denotes	per
T5631	7864-7874	NN	denotes	microarray
T5632	7874-7875	.	denotes	.
T5633	7875-7953	sentence	denotes	The normalised expression values were imported to and analysed by dCHIP [24].
T5634	7876-7879	DT	denotes	The
T5635	7902-7908	NNS	denotes	values
T5636	7880-7890	JJ	denotes	normalised
T5637	7891-7901	NN	denotes	expression
T5638	7914-7922	VBN	denotes	imported
T5639	7909-7913	VBD	denotes	were
T5640	7923-7925	IN	denotes	to
T5641	7926-7929	CC	denotes	and
T5642	7930-7938	VBN	denotes	analysed
T5643	7939-7941	IN	denotes	by
T5644	7942-7947	NN	denotes	dCHIP
T5645	7948-7949	-LRB-	denotes	[
T5646	7949-7951	CD	denotes	24
T5647	7951-7952	-RRB-	denotes	]
T5648	7952-7953	.	denotes	.
T5649	7953-8276	sentence	denotes	Differentially expressed genes were identified by defining the appropriate filtering criteria in the dCHIP software as: lower 90% confidence boundary of fold change between the group means exceeded twofold; the absolute difference between the two groups exceeded 100; the P value threshold of the unpaired t-test was 0.05.
T5650	7954-7968	RB	denotes	Differentially
T5651	7969-7978	VBN	denotes	expressed
T5652	7979-7984	NNS	denotes	genes
T5653	7990-8000	VBN	denotes	identified
T5654	7985-7989	VBD	denotes	were
T5655	8001-8003	IN	denotes	by
T5656	8004-8012	VBG	denotes	defining
T5657	8013-8016	DT	denotes	the
T5658	8039-8047	NNS	denotes	criteria
T5659	8017-8028	JJ	denotes	appropriate
T5660	8029-8038	NN	denotes	filtering
T5661	8048-8050	IN	denotes	in
T5662	8051-8054	DT	denotes	the
T5663	8061-8069	NN	denotes	software
T5664	8055-8060	NN	denotes	dCHIP
T5665	8070-8072	IN	denotes	as
T5666	8072-8074	:	denotes	:
T5667	8074-8079	JJ	denotes	lower
T5668	8082-8083	NN	denotes	%
T5669	8080-8082	CD	denotes	90
T5670	8095-8103	NN	denotes	boundary
T5671	8084-8094	NN	denotes	confidence
T5672	8143-8151	VBN	denotes	exceeded
T5673	8104-8106	IN	denotes	of
T5674	8107-8111	NN	denotes	fold
T5675	8112-8118	NN	denotes	change
T5676	8119-8126	IN	denotes	between
T5677	8127-8130	DT	denotes	the
T5678	8137-8142	NNS	denotes	means
T5679	8131-8136	NN	denotes	group
T5680	8267-8270	VBD	denotes	was
T5681	8152-8159	RB	denotes	twofold
T5682	8159-8160	:	denotes	;
T5683	8161-8164	DT	denotes	the
T5684	8174-8184	NN	denotes	difference
T5685	8165-8173	JJ	denotes	absolute
T5686	8208-8216	VBD	denotes	exceeded
T5687	8185-8192	IN	denotes	between
T5688	8193-8196	DT	denotes	the
T5689	8201-8207	NNS	denotes	groups
T5690	8197-8200	CD	denotes	two
T5691	8217-8220	CD	denotes	100
T5692	8220-8221	:	denotes	;
T5693	8222-8225	DT	denotes	the
T5694	8234-8243	NN	denotes	threshold
T5695	8226-8227	NN	denotes	P
T5696	8228-8233	NN	denotes	value
T5697	8244-8246	IN	denotes	of
T5698	8247-8250	DT	denotes	the
T5699	8262-8266	NN	denotes	test
T5700	8251-8259	JJ	denotes	unpaired
T5701	8260-8261	NN	denotes	t
T5702	8261-8262	HYPH	denotes	-
T5703	8271-8275	CD	denotes	0.05
T5704	8275-8276	.	denotes	.
T5705	8276-8422	sentence	denotes	The false discovery rate was established with a permutation test for each pairwise comparison to estimate the proportion of false-positive genes.
T5706	8277-8280	DT	denotes	The
T5707	8297-8301	NN	denotes	rate
T5708	8281-8286	JJ	denotes	false
T5709	8287-8296	NN	denotes	discovery
T5710	8306-8317	VBN	denotes	established
T5711	8302-8305	VBD	denotes	was
T5712	8318-8322	IN	denotes	with
T5713	8323-8324	DT	denotes	a
T5714	8337-8341	NN	denotes	test
T5715	8325-8336	NN	denotes	permutation
T5716	8342-8345	IN	denotes	for
T5717	8346-8350	DT	denotes	each
T5718	8360-8370	NN	denotes	comparison
T5719	8351-8359	JJ	denotes	pairwise
T5720	8371-8373	TO	denotes	to
T5721	8374-8382	VB	denotes	estimate
T5722	8383-8386	DT	denotes	the
T5723	8387-8397	NN	denotes	proportion
T5724	8398-8400	IN	denotes	of
T5725	8401-8406	JJ	denotes	false
T5726	8407-8415	JJ	denotes	positive
T5727	8406-8407	HYPH	denotes	-
T5728	8416-8421	NNS	denotes	genes
T5729	8421-8422	.	denotes	.
T5730	8422-8533	sentence	denotes	Hierarchical gene clustering was performed with dCHIP to characterise the gene expression patterns during CIA.
T5731	8423-8435	JJ	denotes	Hierarchical
T5732	8441-8451	NN	denotes	clustering
T5733	8436-8440	NN	denotes	gene
T5734	8456-8465	VBN	denotes	performed
T5735	8452-8455	VBD	denotes	was
T5736	8466-8470	IN	denotes	with
T5737	8471-8476	NN	denotes	dCHIP
T5738	8477-8479	TO	denotes	to
T5739	8480-8492	VB	denotes	characterise
T5740	8493-8496	DT	denotes	the
T5741	8513-8521	NNS	denotes	patterns
T5742	8497-8501	NN	denotes	gene
T5743	8502-8512	NN	denotes	expression
T5744	8522-8528	IN	denotes	during
T5745	8529-8532	NN	denotes	CIA
T5746	8532-8533	.	denotes	.
T5747	8533-8775	sentence	denotes	The default clustering algorithm of genes was as follows: the distance between two genes is defined as 1 – r, where r is the Pearson correlation coefficient between the standardised expression values of the two genes across the samples used.
T5748	8534-8537	DT	denotes	The
T5749	8557-8566	NN	denotes	algorithm
T5750	8538-8545	NN	denotes	default
T5751	8546-8556	NN	denotes	clustering
T5752	8576-8579	VBD	denotes	was
T5753	8567-8569	IN	denotes	of
T5754	8570-8575	NNS	denotes	genes
T5755	8626-8633	VBN	denotes	defined
T5756	8580-8582	IN	denotes	as
T5757	8583-8590	VBZ	denotes	follows
T5758	8590-8592	:	denotes	:
T5759	8592-8595	DT	denotes	the
T5760	8596-8604	NN	denotes	distance
T5761	8605-8612	IN	denotes	between
T5762	8613-8616	CD	denotes	two
T5763	8617-8622	NNS	denotes	genes
T5764	8623-8625	VBZ	denotes	is
T5765	8634-8636	IN	denotes	as
T5766	8637-8638	CD	denotes	1
T5767	8641-8642	NN	denotes	r
T5768	8639-8640	HYPH	denotes	–
T5769	8642-8644	,	denotes	,
T5770	8644-8649	WRB	denotes	where
T5771	8652-8654	VBZ	denotes	is
T5772	8650-8651	NN	denotes	r
T5773	8655-8658	DT	denotes	the
T5774	8679-8690	NN	denotes	coefficient
T5775	8659-8666	NNP	denotes	Pearson
T5776	8667-8678	NN	denotes	correlation
T5777	8691-8698	IN	denotes	between
T5778	8699-8702	DT	denotes	the
T5779	8727-8733	NNS	denotes	values
T5780	8703-8715	VBN	denotes	standardised
T5789	8770-8774	VBN	denotes	used
T5790	8774-8775	.	denotes	.
T5791	8775-8947	sentence	denotes	To characterise the functional relationship between differentially expressed genes, Gene Ontology (GO) term classification incorporated in DNA-Chip Analyzer was performed.
T5792	8776-8778	TO	denotes	To
T5793	8779-8791	VB	denotes	characterise
T5794	8937-8946	VBN	denotes	performed
T5795	8792-8795	DT	denotes	the
T5796	8807-8819	NN	denotes	relationship
T5797	8796-8806	JJ	denotes	functional
T5798	8820-8827	IN	denotes	between
T5799	8828-8842	RB	denotes	differentially
T5800	8853-8858	NNS	denotes	genes
T5801	8843-8852	VBN	denotes	expressed
T5802	8858-8860	,	denotes	,
T5803	8860-8864	NN	denotes	Gene
T5804	8865-8873	NN	denotes	Ontology
T5805	8884-8898	NN	denotes	classification
T5806	8874-8875	-LRB-	denotes	(
T5807	8875-8877	NN	denotes	GO
T5808	8877-8878	-RRB-	denotes	)
T5809	8879-8883	NN	denotes	term
T5810	8899-8911	VBN	denotes	incorporated
T5811	8912-8914	IN	denotes	in
T5812	8915-8918	NNP	denotes	DNA
T5813	8919-8923	NNP	denotes	Chip
T5814	8918-8919	HYPH	denotes	-
T5815	8924-8932	NNP	denotes	Analyzer
T5816	8933-8936	VBD	denotes	was
T5817	8946-8947	.	denotes	.
T5818	8947-9065	sentence	denotes	The significant level for a function cluster was set at P < 0.005, and the minimum size of a cluster was three genes.
T5819	8948-8951	DT	denotes	The
T5820	8964-8969	NN	denotes	level
T5821	8952-8963	JJ	denotes	significant
T5822	8997-9000	VBN	denotes	set
T5823	8970-8973	IN	denotes	for
T5824	8974-8975	DT	denotes	a
T5825	8985-8992	NN	denotes	cluster
T5826	8976-8984	NN	denotes	function
T5827	8993-8996	VBD	denotes	was
T5828	9001-9003	IN	denotes	at
T5829	9004-9005	NN	denotes	P
T5830	9006-9007	SYM	denotes	<
T5831	9008-9013	CD	denotes	0.005
T5832	9013-9015	,	denotes	,
T5833	9015-9018	CC	denotes	and
T5834	9019-9022	DT	denotes	the
T5835	9031-9035	NN	denotes	size
T5836	9023-9030	JJ	denotes	minimum
T5837	9049-9052	VBD	denotes	was
T5838	9036-9038	IN	denotes	of
T5839	9039-9040	DT	denotes	a
T5840	9041-9048	NN	denotes	cluster
T5841	9053-9058	CD	denotes	three
T5842	9059-9064	NNS	denotes	genes
T5843	9064-9065	.	denotes	.
T7078	9076-9081	JJ	denotes	Small
T7079	9082-9088	NN	denotes	effect
T7080	9081-9082	HYPH	denotes	-
T7081	9089-9092	NNS	denotes	QTL
T7082	9093-9095	IN	denotes	of
T7083	9096-9099	NN	denotes	CIA
T7084	9100-9102	IN	denotes	in
T7085	9103-9104	-LRB-	denotes	(
T7086	9104-9107	NN	denotes	DBA
T7087	9122-9129	NN	denotes	progeny
T7088	9107-9108	HYPH	denotes	/
T7089	9108-9109	CD	denotes	1
T7090	9110-9111	SYM	denotes	×
T7091	9112-9115	NN	denotes	FVB
T7092	9116-9117	NN	denotes	N
T7093	9115-9116	HYPH	denotes	/
T7094	9117-9118	-RRB-	denotes	)
T7095	9119-9121	NN	denotes	F2
T7096	9129-9259	sentence	denotes	In a previous study, we carried out a genome screen to identify QTL controlling CIA susceptibility in (DBA/1 × FVB/N) F2 progeny.
T7097	9130-9132	IN	denotes	In
T7098	9154-9161	VBD	denotes	carried
T7099	9133-9134	DT	denotes	a
T7100	9144-9149	NN	denotes	study
T7101	9135-9143	JJ	denotes	previous
T7102	9149-9151	,	denotes	,
T7103	9151-9153	PRP	denotes	we
T7104	9162-9165	RP	denotes	out
T7105	9166-9167	DT	denotes	a
T7106	9175-9181	NN	denotes	screen
T7107	9168-9174	NN	denotes	genome
T7108	9182-9184	TO	denotes	to
T7109	9185-9193	VB	denotes	identify
T7110	9194-9197	NN	denotes	QTL
T7111	9198-9209	VBG	denotes	controlling
T7112	9210-9213	NN	denotes	CIA
T7113	9214-9228	NN	denotes	susceptibility
T7114	9229-9231	IN	denotes	in
T7115	9232-9233	-LRB-	denotes	(
T7116	9233-9236	NN	denotes	DBA
T7117	9251-9258	NN	denotes	progeny
T7118	9236-9237	HYPH	denotes	/
T7119	9237-9238	CD	denotes	1
T7120	9239-9240	SYM	denotes	×
T7121	9245-9246	NN	denotes	N
T7122	9241-9244	NN	denotes	FVB
T7123	9244-9245	HYPH	denotes	/
T7124	9246-9247	-RRB-	denotes	)
T7125	9248-9250	NN	denotes	F2
T7126	9258-9259	.	denotes	.
T7127	9259-9408	sentence	denotes	For the phenotype of arthritis severity, only one QTL, Cia2, was identified, with a highly significant logarithm of the odds (LOD) score of 12 [10].
T7128	9260-9263	IN	denotes	For
T7129	9325-9335	VBN	denotes	identified
T7130	9264-9267	DT	denotes	the
T7131	9268-9277	NN	denotes	phenotype
T7132	9278-9280	IN	denotes	of
T7133	9281-9290	NN	denotes	arthritis
T7134	9291-9299	NN	denotes	severity
T7135	9299-9301	,	denotes	,
T7136	9301-9305	RB	denotes	only
T7137	9310-9313	NN	denotes	QTL
T7138	9306-9309	CD	denotes	one
T7139	9313-9315	,	denotes	,
T7140	9315-9319	NN	denotes	Cia2
T7141	9319-9321	,	denotes	,
T7142	9321-9324	VBD	denotes	was
T7143	9335-9337	,	denotes	,
T7144	9337-9341	IN	denotes	with
T7145	9342-9343	DT	denotes	a
T7146	9391-9396	NN	denotes	score
T7147	9344-9350	RB	denotes	highly
T7148	9351-9362	JJ	denotes	significant
T7149	9363-9372	NN	denotes	logarithm
T7150	9373-9375	IN	denotes	of
T7151	9376-9379	DT	denotes	the
T7152	9380-9384	NNS	denotes	odds
T7153	9385-9386	-LRB-	denotes	(
T7154	9386-9389	NN	denotes	LOD
T7155	9389-9390	-RRB-	denotes	)
T7156	9397-9399	IN	denotes	of
T7157	9400-9402	CD	denotes	12
T7158	9403-9404	-LRB-	denotes	[
T7159	9404-9406	CD	denotes	10
T7160	9406-9407	-RRB-	denotes	]
T7161	9407-9408	.	denotes	.
T7162	9408-9629	sentence	denotes	However, Cia2 contributed to only 16% of the phenotype variations, indicating that there should be some small-effect QTL whose contributions to CIA were not big enough to reach the significant threshold value of linkage.
T7163	9409-9416	RB	denotes	However
T7164	9423-9434	VBD	denotes	contributed
T7165	9416-9418	,	denotes	,
T7166	9418-9422	NN	denotes	Cia2
T7167	9435-9437	IN	denotes	to
T7168	9438-9442	RB	denotes	only
T7169	9445-9446	NN	denotes	%
T7170	9443-9445	CD	denotes	16
T7171	9447-9449	IN	denotes	of
T7172	9450-9453	DT	denotes	the
T7173	9464-9474	NNS	denotes	variations
T7174	9454-9463	NN	denotes	phenotype
T7175	9474-9476	,	denotes	,
T7176	9476-9486	VBG	denotes	indicating
T7177	9487-9491	IN	denotes	that
T7178	9505-9507	VB	denotes	be
T7179	9492-9497	EX	denotes	there
T7180	9498-9504	MD	denotes	should
T7181	9508-9512	DT	denotes	some
T7182	9526-9529	NNS	denotes	QTL
T7183	9513-9518	JJ	denotes	small
T7184	9519-9525	NN	denotes	effect
T7185	9518-9519	HYPH	denotes	-
T7186	9530-9535	WP$	denotes	whose
T7187	9536-9549	NNS	denotes	contributions
T7188	9557-9561	VBD	denotes	were
T7189	9550-9552	IN	denotes	to
T7190	9553-9556	NN	denotes	CIA
T7191	9562-9565	RB	denotes	not
T7192	9566-9569	JJ	denotes	big
T7193	9570-9576	RB	denotes	enough
T7194	9577-9579	TO	denotes	to
T7195	9580-9585	VB	denotes	reach
T7196	9586-9589	DT	denotes	the
T7197	9612-9617	NN	denotes	value
T7198	9590-9601	JJ	denotes	significant
T7199	9602-9611	NN	denotes	threshold
T7200	9618-9620	IN	denotes	of
T7201	9621-9628	NN	denotes	linkage
T7202	9628-9629	.	denotes	.
T7203	9629-9751	sentence	denotes	To identify these potential small-effect QTL, we reanalyzed the data using a lower threshold value of linkage (P = 0.05).
T7204	9630-9632	TO	denotes	To
T7205	9633-9641	VB	denotes	identify
T7206	9679-9689	VBD	denotes	reanalyzed
T7207	9642-9647	DT	denotes	these
T7208	9671-9674	NNS	denotes	QTL
T7209	9648-9657	JJ	denotes	potential
T7210	9658-9663	JJ	denotes	small
T7211	9664-9670	NN	denotes	effect
T7212	9663-9664	HYPH	denotes	-
T7213	9674-9676	,	denotes	,
T7214	9676-9678	PRP	denotes	we
T7215	9690-9693	DT	denotes	the
T7216	9694-9698	NNS	denotes	data
T7217	9699-9704	VBG	denotes	using
T7218	9705-9706	DT	denotes	a
T7219	9723-9728	NN	denotes	value
T7220	9707-9712	JJR	denotes	lower
T7221	9713-9722	NN	denotes	threshold
T7222	9729-9731	IN	denotes	of
T7223	9732-9739	NN	denotes	linkage
T7224	9740-9741	-LRB-	denotes	(
T7225	9745-9749	CD	denotes	0.05
T7226	9741-9742	NN	denotes	P
T7227	9743-9744	SYM	denotes	=
T7228	9749-9750	-RRB-	denotes	)
T7229	9750-9751	.	denotes	.
T7230	9751-9985	sentence	denotes	We reasoned that since the main candidate gene of Cia2, complement component C5 (Hc), was proven to be essential for CIA development and because the FVB/N strain is C5 deficient [10,25], some small-effect QTL might be masked by Cia2.
T7231	9752-9754	PRP	denotes	We
T7232	9755-9763	VBD	denotes	reasoned
T7233	9764-9768	IN	denotes	that
T7234	9970-9976	VBN	denotes	masked
T7235	9769-9774	IN	denotes	since
T7236	9842-9848	VBN	denotes	proven
T7237	9775-9778	DT	denotes	the
T7238	9794-9798	NN	denotes	gene
T7239	9779-9783	JJ	denotes	main
T7240	9784-9793	NN	denotes	candidate
T7241	9799-9801	IN	denotes	of
T7242	9802-9806	NN	denotes	Cia2
T7243	9806-9808	,	denotes	,
T7244	9808-9818	NN	denotes	complement
T7245	9829-9831	NN	denotes	C5
T7246	9819-9828	NN	denotes	component
T7247	9832-9833	-LRB-	denotes	(
T7248	9833-9835	NN	denotes	Hc
T7249	9835-9836	-RRB-	denotes	)
T7250	9836-9838	,	denotes	,
T7251	9838-9841	VBD	denotes	was
T7252	9849-9851	TO	denotes	to
T7253	9852-9854	VB	denotes	be
T7254	9855-9864	JJ	denotes	essential
T7255	9865-9868	IN	denotes	for
T7256	9869-9872	NN	denotes	CIA
T7257	9873-9884	NN	denotes	development
T7258	9885-9888	CC	denotes	and
T7259	9889-9896	IN	denotes	because
T7260	9914-9916	VBZ	denotes	is
T7261	9897-9900	DT	denotes	the
T7262	9907-9913	NN	denotes	strain
T7263	9901-9904	NN	denotes	FVB
T7264	9905-9906	NN	denotes	N
T7265	9904-9905	HYPH	denotes	/
T7266	9917-9919	NN	denotes	C5
T7267	9920-9929	JJ	denotes	deficient
T7268	9930-9931	-LRB-	denotes	[
T7269	9934-9936	CD	denotes	25
T7270	9931-9933	CD	denotes	10
T7271	9933-9934	,	denotes	,
T7272	9936-9937	-RRB-	denotes	]
T7273	9937-9939	,	denotes	,
T7274	9939-9943	DT	denotes	some
T7275	9957-9960	NNS	denotes	QTL
T7276	9944-9949	JJ	denotes	small
T7277	9950-9956	NN	denotes	effect
T7278	9949-9950	HYPH	denotes	-
T7279	9961-9966	MD	denotes	might
T7280	9967-9969	VB	denotes	be
T7281	9977-9979	IN	denotes	by
T7282	9980-9984	NN	denotes	Cia2
T7283	9984-9985	.	denotes	.
T7284	9985-10177	sentence	denotes	To exclude the masking effect of C5, we performed linkage analysis with 3 datasets, the first containing all 290 F2 progeny, the second 77 C5+/+ F2 progeny and the third 133 C5+/- F2 progeny.
T7285	9986-9988	TO	denotes	To
T7286	9989-9996	VB	denotes	exclude
T7287	10026-10035	VBD	denotes	performed
T7288	9997-10000	DT	denotes	the
T7289	10009-10015	NN	denotes	effect
T7290	10001-10008	NN	denotes	masking
T7291	10016-10018	IN	denotes	of
T7292	10019-10021	NN	denotes	C5
T7293	10021-10023	,	denotes	,
T7294	10023-10025	PRP	denotes	we
T7295	10036-10043	NN	denotes	linkage
T7296	10044-10052	NN	denotes	analysis
T7297	10053-10057	IN	denotes	with
T7298	10058-10059	CD	denotes	3
T7299	10060-10068	NNS	denotes	datasets
T7300	10068-10070	,	denotes	,
T7301	10070-10073	DT	denotes	the
T7302	10074-10079	JJ	denotes	first
T7303	10080-10090	VBG	denotes	containing
T7304	10091-10094	DT	denotes	all
T7305	10102-10109	NN	denotes	progeny
T7306	10095-10098	CD	denotes	290
T7307	10099-10101	NN	denotes	F2
T7308	10109-10111	,	denotes	,
T7309	10111-10114	DT	denotes	the
T7310	10115-10121	JJ	denotes	second
T7311	10134-10141	NN	denotes	progeny
T7312	10122-10124	CD	denotes	77
T7313	10125-10128	NN	denotes	C5+
T7314	10128-10129	HYPH	denotes	/
T7315	10129-10130	SYM	denotes	+
T7316	10131-10133	NN	denotes	F2
T7317	10142-10145	CC	denotes	and
T7318	10146-10149	DT	denotes	the
T7319	10150-10155	JJ	denotes	third
T7320	10169-10176	NN	denotes	progeny
T7321	10156-10159	CD	denotes	133
T7322	10160-10163	NN	denotes	C5+
T7323	10163-10164	HYPH	denotes	/
T7324	10164-10165	SYM	denotes	-
T7325	10166-10168	NN	denotes	F2
T7326	10176-10177	.	denotes	.
T7327	10177-10315	sentence	denotes	Eight genomic regions were linked to the phenotype of CIA severity (loci 1 to 8, Table 2), with P values varying between 0.043 and 0.003.
T7328	10178-10183	CD	denotes	Eight
T7329	10192-10199	NNS	denotes	regions
T7330	10184-10191	JJ	denotes	genomic
T7331	10205-10211	VBN	denotes	linked
T7332	10200-10204	VBD	denotes	were
T7333	10212-10214	IN	denotes	to
T7334	10215-10218	DT	denotes	the
T7335	10219-10228	NN	denotes	phenotype
T7336	10229-10231	IN	denotes	of
T7337	10232-10235	NN	denotes	CIA
T7338	10236-10244	NN	denotes	severity
T7339	10245-10246	-LRB-	denotes	(
T7340	10259-10264	NN	denotes	Table
T7341	10246-10250	NNS	denotes	loci
T7342	10251-10252	CD	denotes	1
T7343	10253-10255	IN	denotes	to
T7344	10256-10257	CD	denotes	8
T7345	10257-10259	,	denotes	,
T7346	10265-10266	CD	denotes	2
T7347	10266-10267	-RRB-	denotes	)
T7348	10267-10269	,	denotes	,
T7349	10269-10273	IN	denotes	with
T7350	10283-10290	VBG	denotes	varying
T7351	10274-10275	NN	denotes	P
T7352	10276-10282	NNS	denotes	values
T7353	10291-10298	IN	denotes	between
T7354	10299-10304	CD	denotes	0.043
T7355	10305-10308	CC	denotes	and
T7356	10309-10314	CD	denotes	0.003
T7357	10314-10315	.	denotes	.
T7358	10315-10401	sentence	denotes	These eight small-effect QTL were located on chromosomes 5, 6, 7, 10, 11, 16, and 17.
T7359	10316-10321	DT	denotes	These
T7360	10341-10344	NNS	denotes	QTL
T7361	10322-10327	CD	denotes	eight
T7362	10328-10333	JJ	denotes	small
T7363	10334-10340	NN	denotes	effect
T7364	10333-10334	HYPH	denotes	-
T7365	10350-10357	VBN	denotes	located
T7366	10345-10349	VBD	denotes	were
T7367	10358-10360	IN	denotes	on
T7368	10361-10372	NNS	denotes	chromosomes
T7369	10373-10374	CD	denotes	5
T7370	10374-10376	,	denotes	,
T7371	10376-10377	CD	denotes	6
T7372	10377-10379	,	denotes	,
T7373	10379-10380	CD	denotes	7
T7374	10380-10382	,	denotes	,
T7375	10382-10384	CD	denotes	10
T7376	10384-10386	,	denotes	,
T7377	10386-10388	CD	denotes	11
T7378	10388-10390	,	denotes	,
T7379	10390-10392	CD	denotes	16
T7380	10392-10394	,	denotes	,
T7381	10394-10397	CC	denotes	and
T7382	10398-10400	CD	denotes	17
T7383	10400-10401	.	denotes	.
T7384	10401-10453	sentence	denotes	Five loci were identified in at least two datasets.
T7385	10402-10406	CD	denotes	Five
T7386	10407-10411	NNS	denotes	loci
T7387	10417-10427	VBN	denotes	identified
T7388	10412-10416	VBD	denotes	were
T7389	10428-10430	IN	denotes	in
T7390	10431-10433	RB	denotes	at
T7391	10440-10443	CD	denotes	two
T7392	10434-10439	RBS	denotes	least
T7393	10444-10452	NNS	denotes	datasets
T7394	10452-10453	.	denotes	.
T7395	10453-10567	sentence	denotes	Of the eight loci, five had DBA/1 as the susceptibility allele, and three had FVB/N as the susceptibility allele.
T7396	10454-10456	IN	denotes	Of
T7397	10478-10481	VBD	denotes	had
T7398	10457-10460	DT	denotes	the
T7399	10467-10471	NNS	denotes	loci
T7400	10461-10466	CD	denotes	eight
T7401	10471-10473	,	denotes	,
T7402	10473-10477	CD	denotes	five
T7403	10482-10485	NN	denotes	DBA
T7404	10485-10486	HYPH	denotes	/
T7405	10486-10487	CD	denotes	1
T7406	10488-10490	IN	denotes	as
T7407	10491-10494	DT	denotes	the
T7408	10510-10516	NN	denotes	allele
T7409	10495-10509	NN	denotes	susceptibility
T7410	10516-10518	,	denotes	,
T7411	10518-10521	CC	denotes	and
T7412	10522-10527	CD	denotes	three
T7413	10528-10531	VBD	denotes	had
T7414	10532-10535	NN	denotes	FVB
T7415	10536-10537	NN	denotes	N
T7416	10535-10536	HYPH	denotes	/
T7417	10538-10540	IN	denotes	as
T7418	10541-10544	DT	denotes	the
T7419	10560-10566	NN	denotes	allele
T7420	10545-10559	NN	denotes	susceptibility
T7421	10566-10567	.	denotes	.
T7422	10567-10809	sentence	denotes	Lander and Botstein [26] suggested a LOD score of between 2 and 3 to ensure an overall false positive rate of 5%, which means that using a lower threshold value will prevent false negative QTL at the expense of increasing false positive QTL.
T7423	10568-10574	NNP	denotes	Lander
T7424	10593-10602	VBD	denotes	suggested
T7425	10575-10578	CC	denotes	and
T7426	10579-10587	NNP	denotes	Botstein
T7427	10588-10589	-LRB-	denotes	[
T7428	10589-10591	CD	denotes	26
T7429	10591-10592	-RRB-	denotes	]
T7430	10603-10604	DT	denotes	a
T7431	10609-10614	NN	denotes	score
T7432	10605-10608	NN	denotes	LOD
T7433	10615-10617	IN	denotes	of
T7434	10618-10625	IN	denotes	between
T7435	10626-10627	CD	denotes	2
T7436	10628-10631	CC	denotes	and
T7437	10632-10633	CD	denotes	3
T7438	10634-10636	TO	denotes	to
T7439	10637-10643	VB	denotes	ensure
T7440	10644-10646	DT	denotes	an
T7441	10670-10674	NN	denotes	rate
T7442	10647-10654	JJ	denotes	overall
T7443	10655-10660	JJ	denotes	false
T7444	10661-10669	JJ	denotes	positive
T7445	10675-10677	IN	denotes	of
T7446	10678-10679	CD	denotes	5
T7447	10679-10680	NN	denotes	%
T7448	10680-10682	,	denotes	,
T7449	10682-10687	WDT	denotes	which
T7450	10688-10693	VBZ	denotes	means
T7451	10694-10698	IN	denotes	that
T7452	10734-10741	VB	denotes	prevent
T7453	10699-10704	VBG	denotes	using
T7454	10705-10706	DT	denotes	a
T7455	10723-10728	NN	denotes	value
T7456	10707-10712	JJR	denotes	lower
T7457	10713-10722	NN	denotes	threshold
T7458	10729-10733	MD	denotes	will
T7459	10742-10747	JJ	denotes	false
T7460	10748-10756	JJ	denotes	negative
T7461	10757-10760	NNS	denotes	QTL
T7462	10761-10763	IN	denotes	at
T7463	10764-10767	DT	denotes	the
T7464	10768-10775	NN	denotes	expense
T7465	10776-10778	IN	denotes	of
T7466	10779-10789	VBG	denotes	increasing
T7467	10790-10795	JJ	denotes	false
T7468	10796-10804	JJ	denotes	positive
T7469	10805-10808	NNS	denotes	QTL
T7470	10808-10809	.	denotes	.
T7471	10809-10985	sentence	denotes	Being aware of this, we examined these genomic regions to search whether they, or their syntenic genomic regions on the human genome, have been previously linked to arthritis.
T7472	10810-10815	VBG	denotes	Being
T7473	10834-10842	VBD	denotes	examined
T7474	10816-10821	JJ	denotes	aware
T7475	10822-10824	IN	denotes	of
T7476	10825-10829	DT	denotes	this
T7477	10829-10831	,	denotes	,
T7478	10831-10833	PRP	denotes	we
T7479	10843-10848	DT	denotes	these
T7480	10857-10864	NNS	denotes	regions
T7481	10849-10856	JJ	denotes	genomic
T7482	10865-10867	TO	denotes	to
T7483	10868-10874	VB	denotes	search
T7484	10875-10882	IN	denotes	whether
T7485	10965-10971	VBN	denotes	linked
T7486	10883-10887	PRP	denotes	they
T7487	10887-10889	,	denotes	,
T7488	10889-10891	CC	denotes	or
T7489	10892-10897	PRP$	denotes	their
T7490	10915-10922	NNS	denotes	regions
T7491	10898-10906	JJ	denotes	syntenic
T7492	10907-10914	JJ	denotes	genomic
T7493	10923-10925	IN	denotes	on
T7494	10926-10929	DT	denotes	the
T7495	10936-10942	NN	denotes	genome
T7496	10930-10935	JJ	denotes	human
T7497	10942-10944	,	denotes	,
T7498	10944-10948	VBP	denotes	have
T7499	10949-10953	VBN	denotes	been
T7500	10954-10964	RB	denotes	previously
T7501	10972-10974	IN	denotes	to
T7502	10975-10984	NN	denotes	arthritis
T7503	10984-10985	.	denotes	.
T7504	10985-11080	sentence	denotes	Four small-effect QTL overlapped with arthritis QTL on the mouse genome identified previously.
T7505	10986-10990	CD	denotes	Four
T7506	11004-11007	NNS	denotes	QTL
T7507	10991-10996	JJ	denotes	small
T7508	10997-11003	NN	denotes	effect
T7509	10996-10997	HYPH	denotes	-
T7510	11008-11018	VBD	denotes	overlapped
T7511	11019-11023	IN	denotes	with
T7512	11024-11033	NN	denotes	arthritis
T7513	11034-11037	NNS	denotes	QTL
T7514	11038-11040	IN	denotes	on
T7515	11041-11044	DT	denotes	the
T7516	11051-11057	NN	denotes	genome
T7517	11045-11050	NN	denotes	mouse
T7518	11058-11068	VBN	denotes	identified
T7519	11069-11079	RB	denotes	previously
T7520	11079-11080	.	denotes	.
T7521	11080-11191	sentence	denotes	Locus 1 and 2 overlap with Cia13 and Cia14, which control severity of CIA in (DBA/1 × BALB/C) F2 progeny [27].
T7522	11081-11086	NN	denotes	Locus
T7523	11087-11088	CD	denotes	1
T7524	11095-11102	VBP	denotes	overlap
T7525	11089-11092	CC	denotes	and
T7526	11093-11094	CD	denotes	2
T7527	11103-11107	IN	denotes	with
T7528	11108-11113	NN	denotes	Cia13
T7529	11114-11117	CC	denotes	and
T7530	11118-11123	NN	denotes	Cia14
T7531	11123-11125	,	denotes	,
T7532	11125-11130	WDT	denotes	which
T7533	11131-11138	VBP	denotes	control
T7534	11139-11147	NN	denotes	severity
T7535	11148-11150	IN	denotes	of
T7536	11151-11154	NN	denotes	CIA
T7537	11155-11157	IN	denotes	in
T7538	11158-11159	-LRB-	denotes	(
T7539	11159-11162	NN	denotes	DBA
T7540	11178-11185	NN	denotes	progeny
T7541	11162-11163	HYPH	denotes	/
T7542	11163-11164	CD	denotes	1
T7543	11165-11166	SYM	denotes	×
T7544	11167-11171	NN	denotes	BALB
T7545	11172-11173	NN	denotes	C
T7546	11171-11172	HYPH	denotes	/
T7547	11173-11174	-RRB-	denotes	)
T7548	11175-11177	NN	denotes	F2
T7549	11186-11187	-LRB-	denotes	[
T7550	11187-11189	CD	denotes	27
T7551	11189-11190	-RRB-	denotes	]
T7552	11190-11191	.	denotes	.
T7553	11191-11301	sentence	denotes	Locus 5 located on chromosome 10 overlaps with Cia8, which was identified in (DBA/1 × B10.Q) F2 progeny [28].
T7554	11192-11197	NN	denotes	Locus
T7555	11225-11233	VBZ	denotes	overlaps
T7556	11198-11199	CD	denotes	5
T7557	11200-11207	VBN	denotes	located
T7558	11208-11210	IN	denotes	on
T7559	11211-11221	NN	denotes	chromosome
T7560	11222-11224	CD	denotes	10
T7561	11234-11238	IN	denotes	with
T7562	11239-11243	NN	denotes	Cia8
T7563	11243-11245	,	denotes	,
T7564	11245-11250	WDT	denotes	which
T7565	11255-11265	VBN	denotes	identified
T7566	11251-11254	VBD	denotes	was
T7567	11266-11268	IN	denotes	in
T7568	11269-11270	-LRB-	denotes	(
T7569	11270-11273	NN	denotes	DBA
T7570	11288-11295	NN	denotes	progeny
T7571	11273-11274	HYPH	denotes	/
T7572	11274-11275	CD	denotes	1
T7573	11276-11277	SYM	denotes	×
T7574	11278-11283	NN	denotes	B10.Q
T7575	11283-11284	-RRB-	denotes	)
T7576	11285-11287	NN	denotes	F2
T7577	11296-11297	-LRB-	denotes	[
T7578	11297-11299	CD	denotes	28
T7579	11299-11300	-RRB-	denotes	]
T7580	11300-11301	.	denotes	.
T7581	11301-11457	sentence	denotes	Locus 6 overlaps with Pgia7, which controls susceptibility to proteoglycan-induced arthritis (PGIA) and was identified in (BALB/C × DBA/2) F2 progeny [29].
T7582	11302-11307	NN	denotes	Locus
T7583	11310-11318	VBZ	denotes	overlaps
T7584	11308-11309	CD	denotes	6
T7585	11319-11323	IN	denotes	with
T7586	11324-11329	NN	denotes	Pgia7
T7587	11329-11331	,	denotes	,
T7588	11331-11336	WDT	denotes	which
T7589	11337-11345	VBZ	denotes	controls
T7590	11346-11360	NN	denotes	susceptibility
T7591	11361-11363	IN	denotes	to
T7592	11364-11376	NN	denotes	proteoglycan
T7593	11377-11384	VBN	denotes	induced
T7594	11376-11377	HYPH	denotes	-
T7595	11385-11394	NN	denotes	arthritis
T7596	11395-11396	-LRB-	denotes	(
T7597	11396-11400	NN	denotes	PGIA
T7598	11400-11401	-RRB-	denotes	)
T7599	11402-11405	CC	denotes	and
T7600	11406-11409	VBD	denotes	was
T7601	11410-11420	VBN	denotes	identified
T7602	11421-11423	IN	denotes	in
T7603	11424-11425	-LRB-	denotes	(
T7604	11430-11431	NN	denotes	C
T7605	11425-11429	NN	denotes	BALB
T7606	11429-11430	HYPH	denotes	/
T7607	11444-11451	NN	denotes	progeny
T7608	11432-11433	SYM	denotes	×
T7609	11434-11437	NN	denotes	DBA
T7610	11437-11438	HYPH	denotes	/
T7611	11438-11439	CD	denotes	2
T7612	11439-11440	-RRB-	denotes	)
T7613	11441-11443	NN	denotes	F2
T7614	11452-11453	-LRB-	denotes	[
T7615	11453-11455	CD	denotes	29
T7616	11455-11456	-RRB-	denotes	]
T7617	11456-11457	.	denotes	.
T7618	11457-11570	sentence	denotes	The syntenic genomic regions of five small-effect QTL on the human genome have been reported to be linked to RA.
T7619	11458-11461	DT	denotes	The
T7620	11479-11486	NNS	denotes	regions
T7621	11462-11470	JJ	denotes	syntenic
T7622	11471-11478	JJ	denotes	genomic
T7623	11542-11550	VBN	denotes	reported
T7624	11487-11489	IN	denotes	of
T7625	11490-11494	CD	denotes	five
T7626	11508-11511	NNS	denotes	QTL
T7627	11495-11500	JJ	denotes	small
T7628	11501-11507	NN	denotes	effect
T7629	11500-11501	HYPH	denotes	-
T7630	11512-11514	IN	denotes	on
T7631	11515-11518	DT	denotes	the
T7632	11525-11531	NN	denotes	genome
T7633	11519-11524	JJ	denotes	human
T7634	11532-11536	VBP	denotes	have
T7635	11537-11541	VBN	denotes	been
T7636	11551-11553	TO	denotes	to
T7637	11557-11563	VBN	denotes	linked
T7638	11554-11556	VB	denotes	be
T7639	11564-11566	IN	denotes	to
T7640	11567-11569	NN	denotes	RA
T7641	11569-11570	.	denotes	.
T7642	11570-11929	sentence	denotes	These are genomic regions 22q11 and 12p13-q24 on chromosome 22 and 12 (the counterparts of locus 2), 12p13-pter on chromosome 12 (the counterpart of locus 3), 21q22-qter and 10q22-23 on chromosome 21 and 10 (the counterparts of locus 5), 17q21-25 on chromosome 17 (the counterpart of locus 6) and 3q29-qter on chromosome 3 (the counterpart of locus 7) [2,4].
T7643	11571-11576	DT	denotes	These
T7644	11577-11580	VBP	denotes	are
T7645	11581-11588	JJ	denotes	genomic
T7646	11589-11596	NNS	denotes	regions
T7647	11597-11602	NN	denotes	22q11
T7648	11603-11606	CC	denotes	and
T7649	11607-11612	NN	denotes	12p13
T7650	11613-11616	NN	denotes	q24
T7651	11612-11613	HYPH	denotes	-
T7652	11617-11619	IN	denotes	on
T7653	11620-11630	NN	denotes	chromosome
T7654	11631-11633	CD	denotes	22
T7655	11634-11637	CC	denotes	and
T7656	11638-11640	CD	denotes	12
T7657	11641-11642	-LRB-	denotes	(
T7658	11646-11658	NNS	denotes	counterparts
T7659	11642-11645	DT	denotes	the
T7660	11659-11661	IN	denotes	of
T7661	11662-11667	NN	denotes	locus
T7662	11668-11669	CD	denotes	2
T7663	11669-11670	-RRB-	denotes	)
T7664	11670-11672	,	denotes	,
T7665	11672-11677	NN	denotes	12p13
T7666	11678-11682	NN	denotes	pter
T7667	11677-11678	HYPH	denotes	-
T7668	11683-11685	IN	denotes	on
T7669	11686-11696	NN	denotes	chromosome
T7670	11697-11699	CD	denotes	12
T7671	11700-11701	-LRB-	denotes	(
T7672	11705-11716	NN	denotes	counterpart
T7673	11701-11704	DT	denotes	the
T7674	11717-11719	IN	denotes	of
T7675	11720-11725	NN	denotes	locus
T7676	11726-11727	CD	denotes	3
T7677	11727-11728	-RRB-	denotes	)
T7678	11728-11730	,	denotes	,
T7679	11730-11735	NN	denotes	21q22
T7680	11736-11740	NN	denotes	qter
T7681	11735-11736	HYPH	denotes	-
T7682	11741-11744	CC	denotes	and
T7683	11745-11750	NN	denotes	10q22
T7684	11750-11751	HYPH	denotes	-
T7685	11751-11753	CD	denotes	23
T7686	11754-11756	IN	denotes	on
T7687	11757-11767	NN	denotes	chromosome
T7688	11768-11770	CD	denotes	21
T7689	11771-11774	CC	denotes	and
T7690	11775-11777	CD	denotes	10
T7691	11778-11779	-LRB-	denotes	(
T7692	11783-11795	NNS	denotes	counterparts
T7693	11779-11782	DT	denotes	the
T7694	11796-11798	IN	denotes	of
T7695	11799-11804	NN	denotes	locus
T7696	11805-11806	CD	denotes	5
T7697	11806-11807	-RRB-	denotes	)
T7698	11807-11809	,	denotes	,
T7699	11809-11814	NN	denotes	17q21
T7700	11814-11815	HYPH	denotes	-
T7701	11815-11817	CD	denotes	25
T7702	11818-11820	IN	denotes	on
T7703	11821-11831	NN	denotes	chromosome
T7704	11832-11834	CD	denotes	17
T7705	11835-11836	-LRB-	denotes	(
T7706	11840-11851	NN	denotes	counterpart
T7707	11836-11839	DT	denotes	the
T7708	11852-11854	IN	denotes	of
T7709	11855-11860	NN	denotes	locus
T7710	11861-11862	CD	denotes	6
T7711	11862-11863	-RRB-	denotes	)
T7712	11864-11867	CC	denotes	and
T7713	11868-11872	NN	denotes	3q29
T7714	11873-11877	NN	denotes	qter
T7715	11872-11873	HYPH	denotes	-
T7716	11878-11880	IN	denotes	on
T7717	11881-11891	NN	denotes	chromosome
T7718	11892-11893	CD	denotes	3
T7719	11894-11895	-LRB-	denotes	(
T7720	11899-11910	NN	denotes	counterpart
T7721	11895-11898	DT	denotes	the
T7722	11911-11913	IN	denotes	of
T7723	11914-11919	NN	denotes	locus
T7724	11920-11921	CD	denotes	7
T7725	11921-11922	-RRB-	denotes	)
T7726	11923-11924	-LRB-	denotes	[
T7727	11926-11927	CD	denotes	4
T7728	11924-11925	CD	denotes	2
T7729	11925-11926	,	denotes	,
T7730	11927-11928	-RRB-	denotes	]
T7731	11928-11929	.	denotes	.
T8319	11962-11971	VBN	denotes	expressed
T8320	11977-12071	sentence	denotes	We detected the gene expression profiles using three mice per group, which is a small number.
T8321	11978-11980	PRP	denotes	We
T8322	11981-11989	VBD	denotes	detected
T8314	11931-11937	NN	denotes	Strain
T8315	11938-11946	JJ	denotes	specific
T8316	11937-11938	HYPH	denotes	-
T8317	11972-11977	NNS	denotes	genes
T8318	11947-11961	RB	denotes	differentially
T8323	11990-11993	DT	denotes	the
T8324	12010-12018	NNS	denotes	profiles
T8325	11994-11998	NN	denotes	gene
T8326	11999-12009	NN	denotes	expression
T8327	12019-12024	VBG	denotes	using
T8328	12025-12030	CD	denotes	three
T8329	12031-12035	NNS	denotes	mice
T8330	12036-12039	IN	denotes	per
T8331	12040-12045	NN	denotes	group
T8332	12045-12047	,	denotes	,
T8333	12047-12052	WDT	denotes	which
T8334	12053-12055	VBZ	denotes	is
T8335	12056-12057	DT	denotes	a
T8336	12064-12070	NN	denotes	number
T8337	12058-12063	JJ	denotes	small
T8338	12070-12071	.	denotes	.
T8339	12071-12203	sentence	denotes	Being aware of the importance of data reproducibility, we determined the coefficient of variation (CV) to measure data variability.
T8340	12072-12077	VBG	denotes	Being
T8341	12130-12140	VBD	denotes	determined
T8342	12078-12083	JJ	denotes	aware
T8343	12084-12086	IN	denotes	of
T8344	12087-12090	DT	denotes	the
T8345	12091-12101	NN	denotes	importance
T8346	12102-12104	IN	denotes	of
T8347	12105-12109	NNS	denotes	data
T8348	12110-12125	NN	denotes	reproducibility
T8349	12125-12127	,	denotes	,
T8350	12127-12129	PRP	denotes	we
T8351	12141-12144	DT	denotes	the
T8352	12145-12156	NN	denotes	coefficient
T8353	12157-12159	IN	denotes	of
T8354	12160-12169	NN	denotes	variation
T8355	12170-12171	-LRB-	denotes	(
T8356	12171-12173	NN	denotes	CV
T8357	12173-12174	-RRB-	denotes	)
T8358	12175-12177	TO	denotes	to
T8359	12178-12185	VB	denotes	measure
T8360	12186-12190	NNS	denotes	data
T8361	12191-12202	NN	denotes	variability
T8362	12202-12203	.	denotes	.
T8363	12203-12294	sentence	denotes	The CV for each gene on the chip and the mean CV for the entire probe set were calculated.
T8364	12204-12207	DT	denotes	The
T8365	12208-12210	NN	denotes	CV
T8366	12283-12293	VBN	denotes	calculated
T8367	12211-12214	IN	denotes	for
T8368	12215-12219	DT	denotes	each
T8369	12220-12224	NN	denotes	gene
T8370	12225-12227	IN	denotes	on
T8371	12228-12231	DT	denotes	the
T8372	12232-12236	NN	denotes	chip
T8373	12237-12240	CC	denotes	and
T8374	12241-12244	DT	denotes	the
T8375	12250-12252	NN	denotes	CV
T8376	12245-12249	JJ	denotes	mean
T8377	12253-12256	IN	denotes	for
T8378	12257-12260	DT	denotes	the
T8379	12268-12273	NN	denotes	probe
T8380	12261-12267	JJ	denotes	entire
T8381	12274-12277	VBN	denotes	set
T8382	12278-12282	VBD	denotes	were
T8383	12293-12294	.	denotes	.
T8384	12294-12465	sentence	denotes	The mean CV ranged between 18.4% and 25.8% for all experimental groups, and this relatively low CV indicated that these data could be used for further analysis (Table 1).
T8385	12295-12298	DT	denotes	The
T8386	12304-12306	NN	denotes	CV
T8387	12299-12303	JJ	denotes	mean
T8388	12307-12313	VBD	denotes	ranged
T8389	12314-12321	IN	denotes	between
T8390	12322-12326	CD	denotes	18.4
T8391	12326-12327	NN	denotes	%
T8392	12328-12331	CC	denotes	and
T8393	12332-12336	CD	denotes	25.8
T8394	12336-12337	NN	denotes	%
T8395	12338-12341	IN	denotes	for
T8396	12342-12345	DT	denotes	all
T8397	12359-12365	NNS	denotes	groups
T8398	12346-12358	JJ	denotes	experimental
T8399	12365-12367	,	denotes	,
T8400	12367-12370	CC	denotes	and
T8401	12371-12375	DT	denotes	this
T8402	12391-12393	NN	denotes	CV
T8403	12376-12386	RB	denotes	relatively
T8404	12387-12390	JJ	denotes	low
T8405	12394-12403	VBD	denotes	indicated
T8406	12404-12408	IN	denotes	that
T8407	12429-12433	VBN	denotes	used
T8408	12409-12414	DT	denotes	these
T8409	12415-12419	NNS	denotes	data
T8410	12420-12425	MD	denotes	could
T8411	12426-12428	VB	denotes	be
T8412	12434-12437	IN	denotes	for
T8413	12438-12445	JJ	denotes	further
T8414	12446-12454	NN	denotes	analysis
T8415	12455-12456	-LRB-	denotes	(
T8416	12456-12461	NN	denotes	Table
T8417	12462-12463	CD	denotes	1
T8418	12463-12464	-RRB-	denotes	)
T8419	12464-12465	.	denotes	.
T8420	12465-12663	sentence	denotes	To search for strain-specific differentially expressed genes, we performed comparisons of gene expression between the DBA/1 and FVB/N strains at all four phases of CIA, including NC, PI, OA and CA.
T8421	12466-12468	TO	denotes	To
T8422	12469-12475	VB	denotes	search
T8423	12531-12540	VBD	denotes	performed
T8424	12476-12479	IN	denotes	for
T8425	12480-12486	NN	denotes	strain
T8426	12487-12495	JJ	denotes	specific
T8427	12486-12487	HYPH	denotes	-
T8428	12521-12526	NNS	denotes	genes
T8429	12496-12510	RB	denotes	differentially
T8430	12511-12520	VBN	denotes	expressed
T8431	12526-12528	,	denotes	,
T8432	12528-12530	PRP	denotes	we
T8433	12541-12552	NNS	denotes	comparisons
T8434	12553-12555	IN	denotes	of
T8435	12556-12560	NN	denotes	gene
T8436	12561-12571	NN	denotes	expression
T8437	12572-12579	IN	denotes	between
T8438	12580-12583	DT	denotes	the
T8439	12600-12607	NNS	denotes	strains
T8440	12584-12587	NN	denotes	DBA
T8441	12587-12588	HYPH	denotes	/
T8442	12588-12589	CD	denotes	1
T8443	12590-12593	CC	denotes	and
T8444	12594-12597	NN	denotes	FVB
T8445	12598-12599	NN	denotes	N
T8446	12597-12598	HYPH	denotes	/
T8447	12608-12610	IN	denotes	at
T8448	12611-12614	DT	denotes	all
T8449	12620-12626	NNS	denotes	phases
T8450	12615-12619	CD	denotes	four
T8451	12627-12629	IN	denotes	of
T8452	12630-12633	NN	denotes	CIA
T8453	12633-12635	,	denotes	,
T8454	12635-12644	VBG	denotes	including
T8455	12645-12647	NN	denotes	NC
T8456	12647-12649	,	denotes	,
T8457	12649-12651	NN	denotes	PI
T8458	12651-12653	,	denotes	,
T8459	12653-12655	NN	denotes	OA
T8460	12656-12659	CC	denotes	and
T8461	12660-12662	NN	denotes	CA
T8462	12662-12663	.	denotes	.
T8463	12663-12769	sentence	denotes	For the naive mice without immunisation, 361 genes were differentially expressed between the two strains.
T8464	12664-12667	IN	denotes	For
T8465	12735-12744	VBN	denotes	expressed
T8466	12668-12671	DT	denotes	the
T8467	12678-12682	NNS	denotes	mice
T8468	12672-12677	JJ	denotes	naive
T8469	12683-12690	IN	denotes	without
T8470	12691-12703	NN	denotes	immunisation
T8471	12703-12705	,	denotes	,
T8472	12705-12708	CD	denotes	361
T8473	12709-12714	NNS	denotes	genes
T8474	12715-12719	VBD	denotes	were
T8475	12720-12734	RB	denotes	differentially
T8476	12745-12752	IN	denotes	between
T8477	12753-12756	DT	denotes	the
T8478	12761-12768	NNS	denotes	strains
T8479	12757-12760	CD	denotes	two
T8480	12768-12769	.	denotes	.
T8481	12769-12896	sentence	denotes	On day 10 after immunisation, when both strains did not show any sign of the disease, 141 genes were differentially expressed.
T8482	12770-12772	IN	denotes	On
T8483	12886-12895	VBN	denotes	expressed
T8484	12773-12776	NN	denotes	day
T8485	12777-12779	CD	denotes	10
T8486	12780-12785	IN	denotes	after
T8487	12786-12798	NN	denotes	immunisation
T8488	12798-12800	,	denotes	,
T8489	12800-12804	WRB	denotes	when
T8490	12826-12830	VB	denotes	show
T8491	12805-12809	DT	denotes	both
T8492	12810-12817	NNS	denotes	strains
T8493	12818-12821	VBD	denotes	did
T8494	12822-12825	RB	denotes	not
T8495	12831-12834	DT	denotes	any
T8496	12835-12839	NN	denotes	sign
T8497	12840-12842	IN	denotes	of
T8498	12843-12846	DT	denotes	the
T8499	12847-12854	NN	denotes	disease
T8500	12854-12856	,	denotes	,
T8501	12856-12859	CD	denotes	141
T8502	12860-12865	NNS	denotes	genes
T8503	12866-12870	VBD	denotes	were
T8504	12871-12885	RB	denotes	differentially
T8505	12895-12896	.	denotes	.
T8506	12896-13059	sentence	denotes	After DBA/1 mice developed CIA, 184 and 85 differentially expressed genes were identified between these two strains at the onset and chronic phases, respectively.
T8507	12897-12902	IN	denotes	After
T8508	12914-12923	VBD	denotes	developed
T8509	12903-12906	NN	denotes	DBA
T8510	12909-12913	NNS	denotes	mice
T8511	12906-12907	HYPH	denotes	/
T8512	12907-12908	CD	denotes	1
T8513	12976-12986	VBN	denotes	identified
T8514	12924-12927	NN	denotes	CIA
T8515	12927-12929	,	denotes	,
T8516	12929-12932	CD	denotes	184
T8517	12965-12970	NNS	denotes	genes
T8518	12933-12936	CC	denotes	and
T8519	12937-12939	CD	denotes	85
T8520	12940-12954	RB	denotes	differentially
T8521	12955-12964	VBN	denotes	expressed
T8522	12971-12975	VBD	denotes	were
T8523	12987-12994	IN	denotes	between
T8524	12995-13000	DT	denotes	these
T8525	13005-13012	NNS	denotes	strains
T8526	13001-13004	CD	denotes	two
T8527	13013-13015	IN	denotes	at
T8528	13016-13019	DT	denotes	the
T8529	13038-13044	NNS	denotes	phases
T8530	13020-13025	NN	denotes	onset
T8531	13026-13029	CC	denotes	and
T8532	13030-13037	JJ	denotes	chronic
T8533	13044-13046	,	denotes	,
T8534	13046-13058	RB	denotes	respectively
T8535	13058-13059	.	denotes	.
T8536	13059-13227	sentence	denotes	When the lists of the differentially expressed genes at the four phases were merged and overlapping genes were excluded, 509 genes were identified (Additional file 1).
T8537	13060-13064	WRB	denotes	When
T8538	13137-13143	VBN	denotes	merged
T8539	13065-13068	DT	denotes	the
T8540	13069-13074	NNS	denotes	lists
T8541	13075-13077	IN	denotes	of
T8542	13078-13081	DT	denotes	the
T8543	13107-13112	NNS	denotes	genes
T8544	13082-13096	RB	denotes	differentially
T8545	13097-13106	VBN	denotes	expressed
T8546	13113-13115	IN	denotes	at
T8547	13116-13119	DT	denotes	the
T8548	13125-13131	NNS	denotes	phases
T8549	13120-13124	CD	denotes	four
T8550	13132-13136	VBD	denotes	were
T8551	13196-13206	VBN	denotes	identified
T8552	13144-13147	CC	denotes	and
T8553	13148-13159	VBG	denotes	overlapping
T8554	13160-13165	NNS	denotes	genes
T8555	13171-13179	VBN	denotes	excluded
T8556	13166-13170	VBD	denotes	were
T8557	13179-13181	,	denotes	,
T8558	13181-13184	CD	denotes	509
T8559	13185-13190	NNS	denotes	genes
T8560	13191-13195	VBD	denotes	were
T8561	13207-13208	-LRB-	denotes	(
T8562	13219-13223	NN	denotes	file
T8563	13208-13218	JJ	denotes	Additional
T8564	13224-13225	CD	denotes	1
T8565	13225-13226	-RRB-	denotes	)
T8566	13226-13227	.	denotes	.
T8567	13227-13327	sentence	denotes	Twenty-one genes consistently showed differential expression between the two strains at all phases.
T8568	13228-13234	CD	denotes	Twenty
T8569	13235-13238	CD	denotes	one
T8570	13234-13235	HYPH	denotes	-
T8571	13239-13244	NNS	denotes	genes
T8572	13258-13264	VBD	denotes	showed
T8573	13245-13257	RB	denotes	consistently
T8574	13265-13277	JJ	denotes	differential
T8575	13278-13288	NN	denotes	expression
T8576	13289-13296	IN	denotes	between
T8577	13297-13300	DT	denotes	the
T8578	13305-13312	NNS	denotes	strains
T8579	13301-13304	CD	denotes	two
T8580	13313-13315	IN	denotes	at
T8581	13316-13319	DT	denotes	all
T8582	13320-13326	NNS	denotes	phases
T8583	13326-13327	.	denotes	.
T8584	13327-13488	sentence	denotes	Besides these 21 genes, only 3 additional genes were strain-specific differentially expressed during the 3 phases after CIA induction (PI, OA and CA; Figure 1).
T8585	13328-13335	IN	denotes	Besides
T8586	13412-13421	VBN	denotes	expressed
T8587	13336-13341	DT	denotes	these
T8588	13345-13350	NNS	denotes	genes
T8589	13342-13344	CD	denotes	21
T8590	13350-13352	,	denotes	,
T8591	13352-13356	RB	denotes	only
T8592	13370-13375	NNS	denotes	genes
T8593	13357-13358	CD	denotes	3
T8594	13359-13369	JJ	denotes	additional
T8595	13376-13380	VBD	denotes	were
T8596	13381-13387	NN	denotes	strain
T8597	13388-13396	RB	denotes	specific
T8598	13387-13388	HYPH	denotes	-
T8599	13397-13411	RB	denotes	differentially
T8600	13422-13428	IN	denotes	during
T8601	13429-13432	DT	denotes	the
T8602	13435-13441	NNS	denotes	phases
T8603	13433-13434	CD	denotes	3
T8604	13442-13447	IN	denotes	after
T8605	13448-13451	NN	denotes	CIA
T8606	13452-13461	NN	denotes	induction
T8607	13462-13463	-LRB-	denotes	(
T8608	13478-13484	NN	denotes	Figure
T8609	13463-13465	NN	denotes	PI
T8610	13465-13467	,	denotes	,
T8611	13467-13469	NN	denotes	OA
T8612	13470-13473	CC	denotes	and
T8613	13474-13476	NN	denotes	CA
T8614	13476-13477	:	denotes	;
T8615	13485-13486	CD	denotes	1
T8616	13486-13487	-RRB-	denotes	)
T8617	13487-13488	.	denotes	.
T9552	13490-13497	NN	denotes	Disease
T9553	13498-13506	JJ	denotes	specific
T9554	13497-13498	HYPH	denotes	-
T9555	13532-13537	NNS	denotes	genes
T9556	13507-13521	RB	denotes	differentially
T9557	13522-13531	VBN	denotes	expressed
T9558	13537-13711	sentence	denotes	To identify the disease-specific differentially expressed genes in CIA, we detected the genes that were differentially expressed in LNs during CIA in the susceptible strain.
T9559	13538-13540	TO	denotes	To
T9560	13541-13549	VB	denotes	identify
T9561	13613-13621	VBD	denotes	detected
T9562	13550-13553	DT	denotes	the
T9563	13596-13601	NNS	denotes	genes
T9564	13554-13561	NN	denotes	disease
T9565	13562-13570	JJ	denotes	specific
T9566	13561-13562	HYPH	denotes	-
T9567	13571-13585	RB	denotes	differentially
T9568	13586-13595	VBN	denotes	expressed
T9569	13602-13604	IN	denotes	in
T9570	13605-13608	NN	denotes	CIA
T9571	13608-13610	,	denotes	,
T9572	13610-13612	PRP	denotes	we
T9573	13622-13625	DT	denotes	the
T9574	13626-13631	NNS	denotes	genes
T9575	13632-13636	WDT	denotes	that
T9576	13657-13666	VBN	denotes	expressed
T9577	13637-13641	VBD	denotes	were
T9578	13642-13656	RB	denotes	differentially
T9579	13667-13669	IN	denotes	in
T9580	13670-13673	NNS	denotes	LNs
T9581	13674-13680	IN	denotes	during
T9582	13681-13684	NN	denotes	CIA
T9583	13685-13687	IN	denotes	in
T9584	13688-13691	DT	denotes	the
T9585	13704-13710	NN	denotes	strain
T9586	13692-13703	JJ	denotes	susceptible
T9587	13710-13711	.	denotes	.
T9588	13711-13790	sentence	denotes	Three experimental conditions, PI, OA and CA, were compared with the NC group.
T9589	13712-13717	CD	denotes	Three
T9590	13731-13741	NNS	denotes	conditions
T9591	13718-13730	JJ	denotes	experimental
T9592	13763-13771	VBN	denotes	compared
T9593	13741-13743	,	denotes	,
T9594	13743-13745	NN	denotes	PI
T9595	13745-13747	,	denotes	,
T9596	13747-13749	NN	denotes	OA
T9597	13750-13753	CC	denotes	and
T9598	13754-13756	NN	denotes	CA
T9599	13756-13758	,	denotes	,
T9600	13758-13762	VBD	denotes	were
T9601	13772-13776	IN	denotes	with
T9602	13777-13780	DT	denotes	the
T9603	13784-13789	NN	denotes	group
T9604	13781-13783	NN	denotes	NC
T9605	13789-13790	.	denotes	.
T9606	13790-13996	sentence	denotes	On day 10 after immunisation, 102 genes were differentially expressed – most of them were upregulated (78 out of 102) – while at the onset phase of the disease, only 26 genes were differentially expressed.
T9607	13791-13793	IN	denotes	On
T9608	13881-13892	VBN	denotes	upregulated
T9609	13794-13797	NN	denotes	day
T9610	13798-13800	CD	denotes	10
T9611	13801-13806	IN	denotes	after
T9612	13807-13819	NN	denotes	immunisation
T9613	13819-13821	,	denotes	,
T9614	13821-13824	CD	denotes	102
T9615	13825-13830	NNS	denotes	genes
T9616	13851-13860	VBN	denotes	expressed
T9617	13831-13835	VBD	denotes	were
T9618	13836-13850	RB	denotes	differentially
T9619	13861-13862	,	denotes	–
T9620	13863-13867	JJS	denotes	most
T9621	13868-13870	IN	denotes	of
T9622	13871-13875	PRP	denotes	them
T9623	13876-13880	VBD	denotes	were
T9624	13893-13894	-LRB-	denotes	(
T9625	13904-13907	CD	denotes	102
T9626	13894-13896	CD	denotes	78
T9627	13897-13900	IN	denotes	out
T9628	13901-13903	IN	denotes	of
T9629	13907-13908	-RRB-	denotes	)
T9630	13909-13910	,	denotes	–
T9631	13911-13916	IN	denotes	while
T9632	13986-13995	VBN	denotes	expressed
T9633	13917-13919	IN	denotes	at
T9634	13920-13923	DT	denotes	the
T9635	13930-13935	NN	denotes	phase
T9636	13924-13929	NN	denotes	onset
T9637	13936-13938	IN	denotes	of
T9638	13939-13942	DT	denotes	the
T9639	13943-13950	NN	denotes	disease
T9640	13950-13952	,	denotes	,
T9641	13952-13956	RB	denotes	only
T9642	13960-13965	NNS	denotes	genes
T9643	13957-13959	CD	denotes	26
T9644	13966-13970	VBD	denotes	were
T9645	13971-13985	RB	denotes	differentially
T9646	13995-13996	.	denotes	.
T9647	13996-14115	sentence	denotes	At the chronic phase of the disease, 184 differentially expressed genes were identified, with 156 downregulated genes.
T9648	13997-13999	IN	denotes	At
T9649	14074-14084	VBN	denotes	identified
T9650	14000-14003	DT	denotes	the
T9651	14012-14017	NN	denotes	phase
T9652	14004-14011	JJ	denotes	chronic
T9653	14018-14020	IN	denotes	of
T9654	14021-14024	DT	denotes	the
T9655	14025-14032	NN	denotes	disease
T9656	14032-14034	,	denotes	,
T9657	14034-14037	CD	denotes	184
T9658	14063-14068	NNS	denotes	genes
T9659	14038-14052	RB	denotes	differentially
T9660	14053-14062	VBN	denotes	expressed
T9661	14069-14073	VBD	denotes	were
T9662	14084-14086	,	denotes	,
T9663	14086-14090	IN	denotes	with
T9664	14091-14094	CD	denotes	156
T9665	14109-14114	NNS	denotes	genes
T9666	14095-14108	VBN	denotes	downregulated
T9667	14114-14115	.	denotes	.
T9668	14115-14186	sentence	denotes	Only one gene was differentially expressed at all three phases of CIA.
T9669	14116-14120	RB	denotes	Only
T9670	14125-14129	NN	denotes	gene
T9671	14121-14124	CD	denotes	one
T9672	14149-14158	VBN	denotes	expressed
T9673	14130-14133	VBD	denotes	was
T9674	14134-14148	RB	denotes	differentially
T9675	14159-14161	IN	denotes	at
T9676	14162-14165	DT	denotes	all
T9677	14172-14178	NNS	denotes	phases
T9678	14166-14171	CD	denotes	three
T9679	14179-14181	IN	denotes	of
T9680	14182-14185	NN	denotes	CIA
T9681	14185-14186	.	denotes	.
T9682	14186-14334	sentence	denotes	Besides this gene, five, one and six differentially expressed genes were shared by PI with OA, PI with CA and OA with CA, respectively (Figure 2a).
T9683	14187-14194	IN	denotes	Besides
T9684	14260-14266	VBN	denotes	shared
T9685	14195-14199	DT	denotes	this
T9686	14200-14204	NN	denotes	gene
T9687	14204-14206	,	denotes	,
T9688	14206-14210	CD	denotes	five
T9689	14249-14254	NNS	denotes	genes
T9690	14210-14212	,	denotes	,
T9691	14212-14215	CD	denotes	one
T9692	14216-14219	CC	denotes	and
T9693	14220-14223	CD	denotes	six
T9694	14224-14238	RB	denotes	differentially
T9695	14239-14248	VBN	denotes	expressed
T9696	14255-14259	VBD	denotes	were
T9697	14267-14269	IN	denotes	by
T9698	14270-14272	NN	denotes	PI
T9699	14273-14277	IN	denotes	with
T9700	14278-14280	NN	denotes	OA
T9701	14280-14282	,	denotes	,
T9702	14282-14284	NN	denotes	PI
T9703	14285-14289	IN	denotes	with
T9704	14290-14292	NN	denotes	CA
T9705	14293-14296	CC	denotes	and
T9706	14297-14299	NN	denotes	OA
T9707	14300-14304	IN	denotes	with
T9708	14305-14307	NN	denotes	CA
T9709	14307-14309	,	denotes	,
T9710	14309-14321	RB	denotes	respectively
T9711	14322-14323	-LRB-	denotes	(
T9712	14330-14332	NN	denotes	2a
T9713	14323-14329	NN	denotes	Figure
T9714	14332-14333	-RRB-	denotes	)
T9715	14333-14334	.	denotes	.
T9716	14334-14478	sentence	denotes	Taken together, 310 disease-specific differentially expressed genes were differentially regulated during CIA in DBA/1 mice (Additional file 2).
T9717	14335-14340	VBN	denotes	Taken
T9718	14423-14432	VBN	denotes	regulated
T9719	14341-14349	RB	denotes	together
T9720	14349-14351	,	denotes	,
T9721	14351-14354	CD	denotes	310
T9722	14397-14402	NNS	denotes	genes
T9723	14355-14362	NN	denotes	disease
T9724	14363-14371	JJ	denotes	specific
T9725	14362-14363	HYPH	denotes	-
T9726	14372-14386	RB	denotes	differentially
T9727	14387-14396	VBN	denotes	expressed
T9728	14403-14407	VBD	denotes	were
T9729	14408-14422	RB	denotes	differentially
T9730	14433-14439	IN	denotes	during
T9731	14440-14443	NN	denotes	CIA
T9732	14444-14446	IN	denotes	in
T9733	14447-14450	NN	denotes	DBA
T9734	14453-14457	NNS	denotes	mice
T9735	14450-14451	HYPH	denotes	/
T9736	14451-14452	CD	denotes	1
T9737	14458-14459	-LRB-	denotes	(
T9738	14470-14474	NN	denotes	file
T9739	14459-14469	JJ	denotes	Additional
T9740	14475-14476	CD	denotes	2
T9741	14476-14477	-RRB-	denotes	)
T9742	14477-14478	.	denotes	.
T9743	14478-14606	sentence	denotes	To further characterise the gene expression pattern during CIA, we performed hierarchical cluster analysis for these 310 genes.
T9744	14479-14481	TO	denotes	To
T9745	14490-14502	VB	denotes	characterise
T9746	14482-14489	RB	denotes	further
T9747	14546-14555	VBD	denotes	performed
T9748	14503-14506	DT	denotes	the
T9749	14523-14530	NN	denotes	pattern
T9750	14507-14511	NN	denotes	gene
T9751	14512-14522	NN	denotes	expression
T9752	14531-14537	IN	denotes	during
T9753	14538-14541	NN	denotes	CIA
T9754	14541-14543	,	denotes	,
T9755	14543-14545	PRP	denotes	we
T9756	14556-14568	JJ	denotes	hierarchical
T9757	14577-14585	NN	denotes	analysis
T9758	14569-14576	NN	denotes	cluster
T9759	14586-14589	IN	denotes	for
T9760	14590-14595	DT	denotes	these
T9761	14600-14605	NNS	denotes	genes
T9762	14596-14599	CD	denotes	310
T9763	14605-14606	.	denotes	.
T9764	14606-14728	sentence	denotes	Six gene clusters were identified (clusters I to VI, Figure 2b), each with a distinct gene expression pattern during CIA.
T9765	14607-14610	CD	denotes	Six
T9766	14616-14624	NNS	denotes	clusters
T9767	14611-14615	NN	denotes	gene
T9768	14630-14640	VBN	denotes	identified
T9769	14625-14629	VBD	denotes	were
T9770	14641-14642	-LRB-	denotes	(
T9771	14651-14652	CD	denotes	I
T9772	14642-14650	NNS	denotes	clusters
T9773	14653-14655	IN	denotes	to
T9774	14656-14658	CD	denotes	VI
T9775	14658-14660	,	denotes	,
T9776	14660-14666	NN	denotes	Figure
T9777	14667-14669	NN	denotes	2b
T9778	14669-14670	-RRB-	denotes	)
T9779	14670-14672	,	denotes	,
T9780	14672-14676	DT	denotes	each
T9781	14677-14681	IN	denotes	with
T9782	14682-14683	DT	denotes	a
T9783	14709-14716	NN	denotes	pattern
T9784	14684-14692	JJ	denotes	distinct
T9785	14693-14697	NN	denotes	gene
T9786	14698-14708	NN	denotes	expression
T9787	14717-14723	IN	denotes	during
T9788	14724-14727	NN	denotes	CIA
T9789	14727-14728	.	denotes	.
T9790	14728-14822	sentence	denotes	Cluster I contains 16 genes, representing genes that were upregulated after induction of CIA.
T9791	14729-14736	NN	denotes	Cluster
T9792	14739-14747	VBZ	denotes	contains
T9793	14737-14738	CD	denotes	I
T9794	14748-14750	CD	denotes	16
T9795	14751-14756	NNS	denotes	genes
T9796	14756-14758	,	denotes	,
T9797	14758-14770	VBG	denotes	representing
T9798	14771-14776	NNS	denotes	genes
T9799	14777-14781	WDT	denotes	that
T9800	14787-14798	VBN	denotes	upregulated
T9801	14782-14786	VBD	denotes	were
T9802	14799-14804	IN	denotes	after
T9803	14805-14814	NN	denotes	induction
T9804	14815-14817	IN	denotes	of
T9805	14818-14821	NN	denotes	CIA
T9806	14821-14822	.	denotes	.
T9807	14822-14990	sentence	denotes	The expression of these genes reached a peak at the onset phase of the disease and functional clustering results revealed that they are related to the immune response.
T9808	14823-14826	DT	denotes	The
T9809	14827-14837	NN	denotes	expression
T9810	14853-14860	VBD	denotes	reached
T9811	14838-14840	IN	denotes	of
T9812	14841-14846	DT	denotes	these
T9813	14847-14852	NNS	denotes	genes
T9814	14861-14862	DT	denotes	a
T9815	14863-14867	NN	denotes	peak
T9816	14868-14870	IN	denotes	at
T9817	14871-14874	DT	denotes	the
T9818	14881-14886	NN	denotes	phase
T9819	14875-14880	NN	denotes	onset
T9820	14887-14889	IN	denotes	of
T9821	14890-14893	DT	denotes	the
T9822	14894-14901	NN	denotes	disease
T9823	14902-14905	CC	denotes	and
T9824	14906-14916	JJ	denotes	functional
T9825	14928-14935	NNS	denotes	results
T9826	14917-14927	NN	denotes	clustering
T9827	14936-14944	VBD	denotes	revealed
T9828	14945-14949	IN	denotes	that
T9829	14959-14966	VBN	denotes	related
T9830	14950-14954	PRP	denotes	they
T9831	14955-14958	VBP	denotes	are
T9832	14967-14969	IN	denotes	to
T9833	14970-14973	DT	denotes	the
T9834	14981-14989	NN	denotes	response
T9835	14974-14980	JJ	denotes	immune
T9836	14989-14990	.	denotes	.
T9837	14990-15110	sentence	denotes	Cluster II contains 12 genes whose expression was gradually upregulated and reached a peak at the chronic phase of CIA.
T9838	14991-14998	NN	denotes	Cluster
T9839	15002-15010	VBZ	denotes	contains
T9840	14999-15001	CD	denotes	II
T9841	15011-15013	CD	denotes	12
T9842	15014-15019	NNS	denotes	genes
T9843	15020-15025	WP$	denotes	whose
T9844	15026-15036	NN	denotes	expression
T9845	15051-15062	VBN	denotes	upregulated
T9846	15037-15040	VBD	denotes	was
T9847	15041-15050	RB	denotes	gradually
T9848	15063-15066	CC	denotes	and
T9849	15067-15074	VBN	denotes	reached
T9850	15075-15076	DT	denotes	a
T9851	15077-15081	NN	denotes	peak
T9852	15082-15084	IN	denotes	at
T9853	15085-15088	DT	denotes	the
T9854	15097-15102	NN	denotes	phase
T9855	15089-15096	JJ	denotes	chronic
T9856	15103-15105	IN	denotes	of
T9857	15106-15109	NN	denotes	CIA
T9858	15109-15110	.	denotes	.
T9859	15110-15220	sentence	denotes	These genes are mainly related to the immune response, organelle membrane and extracellular region and space.
T9860	15111-15116	DT	denotes	These
T9861	15117-15122	NNS	denotes	genes
T9862	15134-15141	VBN	denotes	related
T9863	15123-15126	VBP	denotes	are
T9864	15127-15133	RB	denotes	mainly
T9865	15142-15144	IN	denotes	to
T9866	15145-15148	DT	denotes	the
T9867	15156-15164	NN	denotes	response
T9868	15149-15155	JJ	denotes	immune
T9869	15164-15166	,	denotes	,
T9870	15166-15175	NN	denotes	organelle
T9871	15176-15184	NN	denotes	membrane
T9872	15185-15188	CC	denotes	and
T9873	15189-15202	JJ	denotes	extracellular
T9874	15203-15209	NN	denotes	region
T9875	15210-15213	CC	denotes	and
T9876	15214-15219	NN	denotes	space
T9877	15219-15220	.	denotes	.
T9878	15220-15294	sentence	denotes	Cluster III contains 78 genes that were only upregulated at the PI phase.
T9879	15221-15228	NN	denotes	Cluster
T9880	15233-15241	VBZ	denotes	contains
T9881	15229-15232	CD	denotes	III
T9882	15242-15244	CD	denotes	78
T9883	15245-15250	NNS	denotes	genes
T9884	15251-15255	WDT	denotes	that
T9885	15266-15277	VBN	denotes	upregulated
T9886	15256-15260	VBD	denotes	were
T9887	15261-15265	RB	denotes	only
T9888	15278-15280	IN	denotes	at
T9889	15281-15284	DT	denotes	the
T9890	15288-15293	NN	denotes	phase
T9891	15285-15287	NN	denotes	PI
T9892	15293-15294	.	denotes	.
T9893	15294-15349	sentence	denotes	These genes are related to the intercellular junction.
T9894	15295-15300	DT	denotes	These
T9895	15301-15306	NNS	denotes	genes
T9896	15311-15318	VBN	denotes	related
T9897	15307-15310	VBP	denotes	are
T9898	15319-15321	IN	denotes	to
T9899	15322-15325	DT	denotes	the
T9900	15340-15348	NN	denotes	junction
T9901	15326-15339	JJ	denotes	intercellular
T9902	15348-15349	.	denotes	.
T9903	15349-15480	sentence	denotes	More than half of the genes (156 of 310) belong to cluster IV and represent genes specifically downregultaed at the chronic phase.
T9904	15350-15354	JJR	denotes	More
T9905	15360-15364	NN	denotes	half
T9906	15355-15359	IN	denotes	than
T9907	15391-15397	VBP	denotes	belong
T9908	15365-15367	IN	denotes	of
T9909	15368-15371	DT	denotes	the
T9910	15372-15377	NNS	denotes	genes
T9911	15378-15379	-LRB-	denotes	(
T9912	15386-15389	CD	denotes	310
T9913	15379-15382	CD	denotes	156
T9914	15383-15385	IN	denotes	of
T9915	15389-15390	-RRB-	denotes	)
T9916	15398-15400	IN	denotes	to
T9917	15401-15408	NN	denotes	cluster
T9918	15409-15411	CD	denotes	IV
T9919	15412-15415	CC	denotes	and
T9920	15416-15425	VBP	denotes	represent
T9921	15426-15431	NNS	denotes	genes
T9922	15432-15444	RB	denotes	specifically
T9923	15445-15458	VBN	denotes	downregultaed
T9924	15459-15461	IN	denotes	at
T9925	15462-15465	DT	denotes	the
T9926	15474-15479	NN	denotes	phase
T9927	15466-15473	JJ	denotes	chronic
T9928	15479-15480	.	denotes	.
T9929	15480-15618	sentence	denotes	These genes are functionally related to lymphocyte proliferation, T cell activation, protein binding as well as the notch signal pathway.
T9930	15481-15486	DT	denotes	These
T9931	15487-15492	NNS	denotes	genes
T9932	15510-15517	VBN	denotes	related
T9933	15493-15496	VBP	denotes	are
T9934	15497-15509	RB	denotes	functionally
T9935	15518-15520	IN	denotes	to
T9936	15521-15531	NN	denotes	lymphocyte
T9937	15532-15545	NN	denotes	proliferation
T9938	15545-15547	,	denotes	,
T9939	15547-15548	NN	denotes	T
T9940	15549-15553	NN	denotes	cell
T9941	15554-15564	NN	denotes	activation
T9942	15564-15566	,	denotes	,
T9943	15566-15573	NN	denotes	protein
T9944	15574-15581	NN	denotes	binding
T9945	15582-15584	RB	denotes	as
T9946	15590-15592	IN	denotes	as
T9947	15585-15589	RB	denotes	well
T9948	15593-15596	DT	denotes	the
T9949	15610-15617	NN	denotes	pathway
T9950	15597-15602	NN	denotes	notch
T9951	15603-15609	NN	denotes	signal
T9952	15617-15618	.	denotes	.
T9953	15618-15680	sentence	denotes	Cluster V contains eight genes downregulated at the PI phase.
T9954	15619-15626	NN	denotes	Cluster
T9955	15629-15637	VBZ	denotes	contains
T9956	15627-15628	CD	denotes	V
T9957	15638-15643	CD	denotes	eight
T9958	15644-15649	NNS	denotes	genes
T9959	15650-15663	VBN	denotes	downregulated
T9960	15664-15666	IN	denotes	at
T9961	15667-15670	DT	denotes	the
T9962	15674-15679	NN	denotes	phase
T9963	15671-15673	NN	denotes	PI
T9964	15679-15680	.	denotes	.
T9965	15680-15740	sentence	denotes	Cluster VI contains 18 genes downregulated at the OA phase.
T9966	15681-15688	NN	denotes	Cluster
T9967	15692-15700	VBZ	denotes	contains
T9968	15689-15691	CD	denotes	VI
T9969	15701-15703	CD	denotes	18
T9970	15704-15709	NNS	denotes	genes
T9971	15710-15723	VBN	denotes	downregulated
T9972	15724-15726	IN	denotes	at
T9973	15727-15730	DT	denotes	the
T9974	15734-15739	NN	denotes	phase
T9975	15731-15733	NN	denotes	OA
T9976	15739-15740	.	denotes	.
T9977	15740-15856	sentence	denotes	The GO term classification showed no functional cluster that was significantly enriched in these two gene clusters.
T9978	15741-15744	DT	denotes	The
T9979	15753-15767	NN	denotes	classification
T9980	15745-15747	NN	denotes	GO
T9981	15748-15752	NN	denotes	term
T9982	15768-15774	VBD	denotes	showed
T9983	15775-15777	DT	denotes	no
T9984	15789-15796	NN	denotes	cluster
T9985	15778-15788	JJ	denotes	functional
T9986	15797-15801	WDT	denotes	that
T9987	15820-15828	VBN	denotes	enriched
T9988	15802-15805	VBD	denotes	was
T9989	15806-15819	RB	denotes	significantly
T9990	15829-15831	IN	denotes	in
T9991	15832-15837	DT	denotes	these
T9992	15847-15855	NNS	denotes	clusters
T9993	15838-15841	CD	denotes	two
T9994	15842-15846	NN	denotes	gene
T9995	15855-15856	.	denotes	.
T10781	15858-15867	NN	denotes	Candidate
T10782	15868-15873	NNS	denotes	genes
T10783	15874-15877	IN	denotes	for
T10784	15878-15881	DT	denotes	the
T10785	15895-15898	NNS	denotes	QTL
T10786	15882-15887	JJ	denotes	small
T10787	15888-15894	NN	denotes	effect
T10788	15887-15888	HYPH	denotes	-
T10789	15899-15901	IN	denotes	of
T10790	15902-15905	NN	denotes	CIA
T10791	15905-16172	sentence	denotes	To identify candidate susceptibility genes for the CIA small-effect QTL, we compared the list of strain-specific differentially expressed genes with the list of disease-specific differentially expressed genes; 117 genes were shared by both lists (Additional file 3).
T10792	15906-15908	TO	denotes	To
T10793	15909-15917	VB	denotes	identify
T10794	15982-15990	VBD	denotes	compared
T10795	15918-15927	NN	denotes	candidate
T10796	15943-15948	NNS	denotes	genes
T10797	15928-15942	NN	denotes	susceptibility
T10798	15949-15952	IN	denotes	for
T10799	15953-15956	DT	denotes	the
T10800	15974-15977	NNS	denotes	QTL
T10801	15957-15960	NN	denotes	CIA
T10802	15961-15966	JJ	denotes	small
T10803	15967-15973	NN	denotes	effect
T10804	15966-15967	HYPH	denotes	-
T10805	15977-15979	,	denotes	,
T10806	15979-15981	PRP	denotes	we
T10807	16131-16137	VBN	denotes	shared
T10808	15991-15994	DT	denotes	the
T10809	15995-15999	NN	denotes	list
T10810	16000-16002	IN	denotes	of
T10811	16003-16009	NN	denotes	strain
T10812	16010-16018	JJ	denotes	specific
T10813	16009-16010	HYPH	denotes	-
T10814	16044-16049	NNS	denotes	genes
T10815	16019-16033	RB	denotes	differentially
T10816	16034-16043	VBN	denotes	expressed
T10817	16050-16054	IN	denotes	with
T10818	16055-16058	DT	denotes	the
T10819	16059-16063	NN	denotes	list
T10820	16064-16066	IN	denotes	of
T10821	16067-16074	NN	denotes	disease
T10822	16075-16083	JJ	denotes	specific
T10823	16074-16075	HYPH	denotes	-
T10824	16109-16114	NNS	denotes	genes
T10825	16084-16098	RB	denotes	differentially
T10826	16099-16108	VBN	denotes	expressed
T10827	16114-16115	:	denotes	;
T10828	16116-16119	CD	denotes	117
T10829	16120-16125	NNS	denotes	genes
T10830	16126-16130	VBD	denotes	were
T10831	16138-16140	IN	denotes	by
T10832	16141-16145	DT	denotes	both
T10833	16146-16151	NNS	denotes	lists
T10834	16152-16153	-LRB-	denotes	(
T10835	16164-16168	NN	denotes	file
T10836	16153-16163	JJ	denotes	Additional
T10837	16169-16170	CD	denotes	3
T10838	16170-16171	-RRB-	denotes	)
T10839	16171-16172	.	denotes	.
T10840	16172-16286	sentence	denotes	Figure 3 visualises positions of the 117 genes retrieved from Ensembl [30] in relation to the 8 small-effect QTL.
T10841	16173-16179	NN	denotes	Figure
T10842	16182-16192	VBZ	denotes	visualises
T10843	16180-16181	CD	denotes	3
T10844	16193-16202	NNS	denotes	positions
T10845	16203-16205	IN	denotes	of
T10846	16206-16209	DT	denotes	the
T10847	16214-16219	NNS	denotes	genes
T10848	16210-16213	CD	denotes	117
T10849	16220-16229	VBN	denotes	retrieved
T10850	16230-16234	IN	denotes	from
T10851	16235-16242	NNP	denotes	Ensembl
T10852	16243-16244	-LRB-	denotes	[
T10853	16244-16246	CD	denotes	30
T10854	16246-16247	-RRB-	denotes	]
T10855	16248-16250	IN	denotes	in
T10856	16251-16259	NN	denotes	relation
T10857	16260-16262	IN	denotes	to
T10858	16263-16266	DT	denotes	the
T10859	16282-16285	NNS	denotes	QTL
T10860	16267-16268	CD	denotes	8
T10861	16269-16274	JJ	denotes	small
T10862	16275-16281	NN	denotes	effect
T10863	16274-16275	HYPH	denotes	-
T10864	16285-16286	.	denotes	.
T10865	16286-16360	sentence	denotes	The eight loci were located on 7 chromosomes, 5, 6, 7, 10, 11, 16 and 17.
T10866	16287-16290	DT	denotes	The
T10867	16297-16301	NNS	denotes	loci
T10868	16291-16296	CD	denotes	eight
T10869	16307-16314	VBN	denotes	located
T10870	16302-16306	VBD	denotes	were
T10871	16315-16317	IN	denotes	on
T10872	16318-16319	CD	denotes	7
T10873	16320-16331	NNS	denotes	chromosomes
T10874	16331-16333	,	denotes	,
T10875	16333-16334	CD	denotes	5
T10876	16334-16336	,	denotes	,
T10877	16336-16337	CD	denotes	6
T10878	16337-16339	,	denotes	,
T10879	16339-16340	CD	denotes	7
T10880	16340-16342	,	denotes	,
T10881	16342-16344	CD	denotes	10
T10882	16344-16346	,	denotes	,
T10883	16346-16348	CD	denotes	11
T10884	16348-16350	,	denotes	,
T10885	16350-16352	CD	denotes	16
T10886	16353-16356	CC	denotes	and
T10887	16357-16359	CD	denotes	17
T10888	16359-16360	.	denotes	.
T10889	16360-16491	sentence	denotes	Since the confidence intervals of QTL in F2 progeny are around 20 cM [26], we used 40 Mb as the confidence intervals for all loci.
T10890	16361-16366	IN	denotes	Since
T10891	16413-16416	VBP	denotes	are
T10892	16367-16370	DT	denotes	the
T10893	16382-16391	NNS	denotes	intervals
T10894	16371-16381	NN	denotes	confidence
T10895	16392-16394	IN	denotes	of
T10896	16395-16398	NNS	denotes	QTL
T10897	16399-16401	IN	denotes	in
T10898	16402-16404	NN	denotes	F2
T10899	16405-16412	NN	denotes	progeny
T10900	16439-16443	VBD	denotes	used
T10901	16417-16423	IN	denotes	around
T10902	16424-16426	CD	denotes	20
T10903	16427-16429	NN	denotes	cM
T10904	16430-16431	-LRB-	denotes	[
T10905	16431-16433	CD	denotes	26
T10906	16433-16434	-RRB-	denotes	]
T10907	16434-16436	,	denotes	,
T10908	16436-16438	PRP	denotes	we
T10909	16444-16446	CD	denotes	40
T10910	16447-16449	NN	denotes	Mb
T10911	16450-16452	IN	denotes	as
T10912	16453-16456	DT	denotes	the
T10913	16468-16477	NNS	denotes	intervals
T10914	16457-16467	NN	denotes	confidence
T10915	16478-16481	IN	denotes	for
T10916	16482-16485	DT	denotes	all
T10917	16486-16490	NNS	denotes	loci
T10918	16490-16491	.	denotes	.
T10919	16491-16574	sentence	denotes	Twenty-one genes were located in the confidence intervals of six of the eight QTL.
T10920	16492-16498	CD	denotes	Twenty
T10921	16499-16502	CD	denotes	one
T10922	16498-16499	HYPH	denotes	-
T10923	16503-16508	NNS	denotes	genes
T10924	16514-16521	VBN	denotes	located
T10925	16509-16513	VBD	denotes	were
T10926	16522-16524	IN	denotes	in
T10927	16525-16528	DT	denotes	the
T10928	16540-16549	NNS	denotes	intervals
T10929	16529-16539	NN	denotes	confidence
T10930	16550-16552	IN	denotes	of
T10931	16553-16556	CD	denotes	six
T10932	16564-16569	CD	denotes	eight
T10933	16557-16559	IN	denotes	of
T10934	16560-16563	DT	denotes	the
T10935	16570-16573	NNS	denotes	QTL
T10936	16573-16574	.	denotes	.
T10937	16574-16763	sentence	denotes	We located 5, 4, 2, 1, 3 and 6 potential candidate genes within the confidence intervals of loci 1, 2, 3, 5, 6 and 8, respectively, while no candidate gene was identified for loci 4 and 7.
T10938	16575-16577	PRP	denotes	We
T10939	16578-16585	VBD	denotes	located
T10940	16586-16587	CD	denotes	5
T10941	16626-16631	NNS	denotes	genes
T10942	16587-16589	,	denotes	,
T10943	16589-16590	CD	denotes	4
T10944	16590-16592	,	denotes	,
T10945	16592-16593	CD	denotes	2
T10946	16593-16595	,	denotes	,
T10947	16595-16596	CD	denotes	1
T10948	16596-16598	,	denotes	,
T10949	16598-16599	CD	denotes	3
T10950	16600-16603	CC	denotes	and
T10951	16604-16605	CD	denotes	6
T10952	16606-16615	JJ	denotes	potential
T10953	16616-16625	NN	denotes	candidate
T10954	16632-16638	IN	denotes	within
T10955	16639-16642	DT	denotes	the
T10956	16654-16663	NNS	denotes	intervals
T10957	16643-16653	NN	denotes	confidence
T10958	16664-16666	IN	denotes	of
T10959	16667-16671	NNS	denotes	loci
T10960	16672-16673	CD	denotes	1
T10961	16673-16675	,	denotes	,
T10962	16675-16676	CD	denotes	2
T10963	16676-16678	,	denotes	,
T10964	16678-16679	CD	denotes	3
T10965	16679-16681	,	denotes	,
T10966	16681-16682	CD	denotes	5
T10967	16682-16684	,	denotes	,
T10968	16684-16685	CD	denotes	6
T10969	16686-16689	CC	denotes	and
T10970	16690-16691	CD	denotes	8
T10971	16691-16693	,	denotes	,
T10972	16693-16705	RB	denotes	respectively
T10973	16705-16707	,	denotes	,
T10974	16707-16712	IN	denotes	while
T10975	16735-16745	VBN	denotes	identified
T10976	16713-16715	DT	denotes	no
T10977	16726-16730	NN	denotes	gene
T10978	16716-16725	NN	denotes	candidate
T10979	16731-16734	VBD	denotes	was
T10980	16746-16749	IN	denotes	for
T10981	16750-16754	NNS	denotes	loci
T10982	16755-16756	CD	denotes	4
T10983	16757-16760	CC	denotes	and
T10984	16761-16762	CD	denotes	7
T10985	16762-16763	.	denotes	.
T10986	16763-16831	sentence	denotes	Table 3 summarises the 21 candidate genes identified in this study.
T10987	16764-16769	NN	denotes	Table
T10988	16772-16782	VBZ	denotes	summarises
T10989	16770-16771	CD	denotes	3
T10990	16783-16786	DT	denotes	the
T10991	16800-16805	NNS	denotes	genes
T10992	16787-16789	CD	denotes	21
T10993	16790-16799	NN	denotes	candidate
T10994	16806-16816	VBN	denotes	identified
T10995	16817-16819	IN	denotes	in
T10996	16820-16824	DT	denotes	this
T10997	16825-16830	NN	denotes	study
T10998	16830-16831	.	denotes	.
T10999	16831-16948	sentence	denotes	Two genes, hspa1a and Oas1a, were upregulated at the OA phase of CIA and Oas1a was also upregulated at the PI phase.
T11000	16832-16835	CD	denotes	Two
T11001	16836-16841	NNS	denotes	genes
T11002	16866-16877	VBN	denotes	upregulated
T11003	16841-16843	,	denotes	,
T11004	16843-16849	NN	denotes	hspa1a
T11005	16850-16853	CC	denotes	and
T11006	16854-16859	NN	denotes	Oas1a
T11007	16859-16861	,	denotes	,
T11008	16861-16865	VBD	denotes	were
T11009	16878-16880	IN	denotes	at
T11010	16881-16884	DT	denotes	the
T11011	16888-16893	NN	denotes	phase
T11012	16885-16887	NN	denotes	OA
T11013	16894-16896	IN	denotes	of
T11014	16897-16900	NN	denotes	CIA
T11015	16901-16904	CC	denotes	and
T11016	16905-16910	NN	denotes	Oas1a
T11017	16920-16931	VBN	denotes	upregulated
T11018	16911-16914	VBD	denotes	was
T11019	16915-16919	RB	denotes	also
T11020	16932-16934	IN	denotes	at
T11021	16935-16938	DT	denotes	the
T11022	16942-16947	NN	denotes	phase
T11023	16939-16941	NN	denotes	PI
T11024	16947-16948	.	denotes	.
T11025	16948-17043	sentence	denotes	Except for these two genes, all other 19 genes were downregulated at the chronic phase of CIA.
T11026	16949-16955	IN	denotes	Except
T11027	17001-17014	VBN	denotes	downregulated
T11028	16956-16959	IN	denotes	for
T11029	16960-16965	DT	denotes	these
T11030	16970-16975	NNS	denotes	genes
T11031	16966-16969	CD	denotes	two
T11032	16975-16977	,	denotes	,
T11033	16977-16980	DT	denotes	all
T11034	16990-16995	NNS	denotes	genes
T11035	16981-16986	JJ	denotes	other
T11036	16987-16989	CD	denotes	19
T11037	16996-17000	VBD	denotes	were
T11038	17015-17017	IN	denotes	at
T11039	17018-17021	DT	denotes	the
T11040	17030-17035	NN	denotes	phase
T11041	17022-17029	JJ	denotes	chronic
T11042	17036-17038	IN	denotes	of
T11043	17039-17042	NN	denotes	CIA
T11044	17042-17043	.	denotes	.
T11045	17043-17140	sentence	denotes	All genes, except hspa1a, showed expression differences between the two strains at the NC phase.
T11046	17044-17047	DT	denotes	All
T11047	17048-17053	NNS	denotes	genes
T11048	17070-17076	VBD	denotes	showed
T11049	17053-17055	,	denotes	,
T11050	17055-17061	IN	denotes	except
T11051	17062-17068	NN	denotes	hspa1a
T11052	17068-17070	,	denotes	,
T11053	17077-17087	NN	denotes	expression
T11054	17088-17099	NNS	denotes	differences
T11055	17100-17107	IN	denotes	between
T11056	17108-17111	DT	denotes	the
T11057	17116-17123	NNS	denotes	strains
T11058	17112-17115	CD	denotes	two
T11059	17124-17126	IN	denotes	at
T11060	17127-17130	DT	denotes	the
T11061	17134-17139	NN	denotes	phase
T11062	17131-17133	NN	denotes	NC
T11063	17139-17140	.	denotes	.
T11064	17140-17252	sentence	denotes	Five genes were differentially expressed at all phases of CIA, including H2-Q10, Mapk14, Pscd1, Kpnb1 and Wdr1.
T11065	17141-17145	CD	denotes	Five
T11066	17146-17151	NNS	denotes	genes
T11067	17172-17181	VBN	denotes	expressed
T11068	17152-17156	VBD	denotes	were
T11069	17157-17171	RB	denotes	differentially
T11070	17182-17184	IN	denotes	at
T11071	17185-17188	DT	denotes	all
T11072	17189-17195	NNS	denotes	phases
T11073	17196-17198	IN	denotes	of
T11074	17199-17202	NN	denotes	CIA
T11075	17202-17204	,	denotes	,
T11076	17204-17213	VBG	denotes	including
T11077	17214-17216	NN	denotes	H2
T11078	17217-17220	NN	denotes	Q10
T11079	17216-17217	HYPH	denotes	-
T11080	17220-17222	,	denotes	,
T11081	17222-17228	NN	denotes	Mapk14
T11082	17228-17230	,	denotes	,
T11083	17230-17235	NN	denotes	Pscd1
T11084	17235-17237	,	denotes	,
T11085	17237-17242	NN	denotes	Kpnb1
T11086	17243-17246	CC	denotes	and
T11087	17247-17251	NN	denotes	Wdr1
T11088	17251-17252	.	denotes	.
T11089	17252-17536	sentence	denotes	Among these five genes, H2-Q10 had a consistently higher expression in the DBA/1 than the FVB/N strain in all CIA phases, while the other four genes had a higher expression in the DBA/1 strain at the early stages, including NC, PI and OA, but a lower expression at the chronic phase.
T11090	17253-17258	IN	denotes	Among
T11091	17284-17287	VBD	denotes	had
T11092	17259-17264	DT	denotes	these
T11093	17270-17275	NNS	denotes	genes
T11094	17265-17269	CD	denotes	five
T11095	17275-17277	,	denotes	,
T11096	17277-17279	NN	denotes	H2
T11097	17280-17283	NN	denotes	Q10
T11098	17279-17280	HYPH	denotes	-
T11099	17288-17289	DT	denotes	a
T11100	17310-17320	NN	denotes	expression
T11101	17290-17302	RB	denotes	consistently
T11102	17303-17309	JJR	denotes	higher
T11103	17321-17323	IN	denotes	in
T11104	17324-17327	DT	denotes	the
T11105	17328-17331	NN	denotes	DBA
T11106	17331-17332	HYPH	denotes	/
T11107	17332-17333	CD	denotes	1
T11108	17334-17338	IN	denotes	than
T11109	17339-17342	DT	denotes	the
T11110	17349-17355	NN	denotes	strain
T11111	17343-17346	NN	denotes	FVB
T11112	17347-17348	NN	denotes	N
T11113	17346-17347	HYPH	denotes	/
T11114	17356-17358	IN	denotes	in
T11115	17359-17362	DT	denotes	all
T11116	17367-17373	NNS	denotes	phases
T11117	17363-17366	NN	denotes	CIA
T11118	17373-17375	,	denotes	,
T11119	17375-17380	IN	denotes	while
T11120	17402-17405	VBD	denotes	had
T11121	17381-17384	DT	denotes	the
T11122	17396-17401	NNS	denotes	genes
T11123	17385-17390	JJ	denotes	other
T11124	17391-17395	CD	denotes	four
T11125	17406-17407	DT	denotes	a
T11126	17415-17425	NN	denotes	expression
T11127	17408-17414	JJR	denotes	higher
T11128	17426-17428	IN	denotes	in
T11129	17429-17432	DT	denotes	the
T11130	17439-17445	NN	denotes	strain
T11131	17433-17436	NN	denotes	DBA
T11132	17436-17437	HYPH	denotes	/
T11133	17437-17438	CD	denotes	1
T11134	17446-17448	IN	denotes	at
T11135	17449-17452	DT	denotes	the
T11136	17459-17465	NNS	denotes	stages
T11137	17453-17458	JJ	denotes	early
T11138	17465-17467	,	denotes	,
T11139	17467-17476	VBG	denotes	including
T11140	17477-17479	NN	denotes	NC
T11141	17479-17481	,	denotes	,
T11142	17481-17483	NN	denotes	PI
T11143	17484-17487	CC	denotes	and
T11144	17488-17490	NN	denotes	OA
T11145	17490-17492	,	denotes	,
T11146	17492-17495	CC	denotes	but
T11147	17496-17497	DT	denotes	a
T11148	17504-17514	NN	denotes	expression
T11149	17498-17503	JJR	denotes	lower
T11150	17515-17517	IN	denotes	at
T11151	17518-17521	DT	denotes	the
T11152	17530-17535	NN	denotes	phase
T11153	17522-17529	JJ	denotes	chronic
T11154	17535-17536	.	denotes	.
T11155	17536-17685	sentence	denotes	GO term classification analysis revealed that the functional cluster of protein kinase cascade was significantly enriched in the 21 candidate genes.
T11156	17537-17539	NN	denotes	GO
T11157	17560-17568	NN	denotes	analysis
T11158	17540-17544	NN	denotes	term
T11159	17545-17559	NN	denotes	classification
T11160	17569-17577	VBD	denotes	revealed
T11161	17578-17582	IN	denotes	that
T11162	17650-17658	VBN	denotes	enriched
T11163	17583-17586	DT	denotes	the
T11164	17598-17605	NN	denotes	cluster
T11165	17587-17597	JJ	denotes	functional
T11166	17606-17608	IN	denotes	of
T11167	17609-17616	NN	denotes	protein
T11168	17624-17631	NN	denotes	cascade
T11169	17617-17623	NN	denotes	kinase
T11170	17632-17635	VBD	denotes	was
T11171	17636-17649	RB	denotes	significantly
T11172	17659-17661	IN	denotes	in
T11173	17662-17665	DT	denotes	the
T11174	17679-17684	NNS	denotes	genes
T11175	17666-17668	CD	denotes	21
T11176	17669-17678	NN	denotes	candidate
T11177	17684-17685	.	denotes	.
T11178	17685-17777	sentence	denotes	This functional cluster contained four genes, including Mapk14, Mapk8ip3, Stat5a and Gna12.
T11179	17686-17690	DT	denotes	This
T11180	17702-17709	NN	denotes	cluster
T11181	17691-17701	JJ	denotes	functional
T11182	17710-17719	VBD	denotes	contained
T11183	17720-17724	CD	denotes	four
T11184	17725-17730	NNS	denotes	genes
T11185	17730-17732	,	denotes	,
T11186	17732-17741	VBG	denotes	including
T11187	17742-17748	NN	denotes	Mapk14
T11188	17748-17750	,	denotes	,
T11189	17750-17758	NN	denotes	Mapk8ip3
T11190	17758-17760	,	denotes	,
T11191	17760-17766	NN	denotes	Stat5a
T11192	17767-17770	CC	denotes	and
T11193	17771-17776	NN	denotes	Gna12
T11194	17776-17777	.	denotes	.
T13481	17790-17792	IN	denotes	In
T13482	17808-17817	VBD	denotes	attempted
T13483	17793-17797	DT	denotes	this
T13484	17798-17803	NN	denotes	study
T13485	17803-17805	,	denotes	,
T13486	17805-17807	PRP	denotes	we
T13487	17818-17821	IN	denotes	for
T13488	17822-17825	DT	denotes	the
T13489	17832-17836	NN	denotes	time
T13490	17826-17831	JJ	denotes	first
T13491	17837-17839	TO	denotes	to
T13492	17840-17848	VB	denotes	identify
T13493	17849-17854	JJ	denotes	small
T13494	17855-17861	NN	denotes	effect
T13495	17854-17855	HYPH	denotes	-
T13496	17862-17865	NNS	denotes	QTL
T13497	17866-17868	IN	denotes	in
T13498	17869-17871	DT	denotes	an
T13499	17875-17882	NN	denotes	progeny
T13500	17872-17874	NN	denotes	F2
T13501	17882-17883	.	denotes	.
T13502	17883-18056	sentence	denotes	Small-effect QTL are defined as those reaching the threshold value of P = 0.05 but that did not reach the significant threshold value suggested by Lander and Botstein [26].
T13503	17884-17889	JJ	denotes	Small
T13504	17890-17896	NN	denotes	effect
T13505	17889-17890	HYPH	denotes	-
T13506	17897-17900	NNS	denotes	QTL
T13507	17905-17912	VBN	denotes	defined
T13508	17901-17904	VBP	denotes	are
T13509	17913-17915	IN	denotes	as
T13510	17916-17921	DT	denotes	those
T13511	17922-17930	VBG	denotes	reaching
T13512	17931-17934	DT	denotes	the
T13513	17945-17950	NN	denotes	value
T13514	17935-17944	NN	denotes	threshold
T13515	17951-17953	IN	denotes	of
T13516	17954-17955	NN	denotes	P
T13517	17958-17962	CD	denotes	0.05
T13518	17956-17957	SYM	denotes	=
T13519	17963-17966	CC	denotes	but
T13520	17967-17971	DT	denotes	that
T13521	17980-17985	VB	denotes	reach
T13522	17972-17975	VBD	denotes	did
T13523	17976-17979	RB	denotes	not
T13524	17986-17989	DT	denotes	the
T13525	18012-18017	NN	denotes	value
T13526	17990-18001	JJ	denotes	significant
T13527	18002-18011	NN	denotes	threshold
T13528	18018-18027	VBN	denotes	suggested
T13529	18028-18030	IN	denotes	by
T13530	18031-18037	NNP	denotes	Lander
T13531	18038-18041	CC	denotes	and
T13532	18042-18050	NNP	denotes	Botstein
T13533	18051-18052	-LRB-	denotes	[
T13534	18052-18054	CD	denotes	26
T13535	18054-18055	-RRB-	denotes	]
T13536	18055-18056	.	denotes	.
T13537	18056-18185	sentence	denotes	Although not significant, there is evidence that most of the eight small-effect QTL likely contain susceptibility genes for CIA.
T13538	18057-18065	IN	denotes	Although
T13539	18070-18081	JJ	denotes	significant
T13540	18066-18069	RB	denotes	not
T13541	18089-18091	VBZ	denotes	is
T13542	18081-18083	,	denotes	,
T13543	18083-18088	EX	denotes	there
T13544	18092-18100	NN	denotes	evidence
T13545	18101-18105	IN	denotes	that
T13546	18148-18155	VBP	denotes	contain
T13547	18106-18110	JJS	denotes	most
T13548	18111-18113	IN	denotes	of
T13549	18114-18117	DT	denotes	the
T13550	18137-18140	NNS	denotes	QTL
T13551	18118-18123	CD	denotes	eight
T13552	18124-18129	JJ	denotes	small
T13553	18130-18136	NN	denotes	effect
T13554	18129-18130	HYPH	denotes	-
T13555	18141-18147	RB	denotes	likely
T13556	18156-18170	NN	denotes	susceptibility
T13557	18171-18176	NNS	denotes	genes
T13558	18177-18180	IN	denotes	for
T13559	18181-18184	NN	denotes	CIA
T13560	18184-18185	.	denotes	.
T13561	18185-18320	sentence	denotes	First, we performed the linkage analysis in three datasets, including all 290 F progeny, 76 C5+/+ F2 progeny and 133 C5+/- F2 progeny.
T13562	18186-18191	RB	denotes	First
T13563	18196-18205	VBD	denotes	performed
T13564	18191-18193	,	denotes	,
T13565	18193-18195	PRP	denotes	we
T13566	18206-18209	DT	denotes	the
T13567	18218-18226	NN	denotes	analysis
T13568	18210-18217	NN	denotes	linkage
T13569	18227-18229	IN	denotes	in
T13570	18230-18235	CD	denotes	three
T13571	18236-18244	NNS	denotes	datasets
T13572	18244-18246	,	denotes	,
T13573	18246-18255	VBG	denotes	including
T13574	18256-18259	DT	denotes	all
T13575	18266-18273	NN	denotes	progeny
T13576	18260-18263	CD	denotes	290
T13577	18264-18265	NN	denotes	F
T13578	18273-18275	,	denotes	,
T13579	18275-18277	CD	denotes	76
T13580	18287-18294	NN	denotes	progeny
T13581	18278-18281	NN	denotes	C5+
T13582	18281-18282	HYPH	denotes	/
T13583	18282-18283	SYM	denotes	+
T13584	18284-18286	NN	denotes	F2
T13585	18295-18298	CC	denotes	and
T13586	18299-18302	CD	denotes	133
T13587	18312-18319	NN	denotes	progeny
T13588	18303-18306	NN	denotes	C5+
T13589	18306-18307	HYPH	denotes	/
T13590	18307-18308	SYM	denotes	-
T13591	18309-18311	NN	denotes	F2
T13592	18319-18320	.	denotes	.
T13593	18320-18441	sentence	denotes	Five of the eight small-effect QTL were identified in at least two datasets, suggesting that these QTL are reproducible.
T13594	18321-18325	CD	denotes	Five
T13595	18333-18338	CD	denotes	eight
T13596	18326-18328	IN	denotes	of
T13597	18329-18332	DT	denotes	the
T13598	18352-18355	NNS	denotes	QTL
T13599	18339-18344	JJ	denotes	small
T13600	18345-18351	NN	denotes	effect
T13601	18344-18345	HYPH	denotes	-
T13602	18361-18371	VBN	denotes	identified
T13603	18356-18360	VBD	denotes	were
T13604	18372-18374	IN	denotes	in
T13605	18375-18377	RB	denotes	at
T13606	18384-18387	CD	denotes	two
T13607	18378-18383	RBS	denotes	least
T13608	18388-18396	NNS	denotes	datasets
T13609	18396-18398	,	denotes	,
T13610	18398-18408	VBG	denotes	suggesting
T13611	18409-18413	IN	denotes	that
T13612	18424-18427	VBP	denotes	are
T13613	18414-18419	DT	denotes	these
T13614	18420-18423	NNS	denotes	QTL
T13615	18428-18440	JJ	denotes	reproducible
T13616	18440-18441	.	denotes	.
T13617	18441-18570	sentence	denotes	Second, many QTL identified in the present study overlap with arthritis QTL previously identified, including loci 1, 2, 5 and 6.
T13618	18442-18448	RB	denotes	Second
T13619	18491-18498	VBP	denotes	overlap
T13620	18448-18450	,	denotes	,
T13621	18450-18454	JJ	denotes	many
T13622	18455-18458	NNS	denotes	QTL
T13623	18459-18469	VBN	denotes	identified
T13624	18470-18472	IN	denotes	in
T13625	18473-18476	DT	denotes	the
T13626	18485-18490	NN	denotes	study
T13627	18477-18484	JJ	denotes	present
T13628	18499-18503	IN	denotes	with
T13629	18504-18513	NN	denotes	arthritis
T13630	18514-18517	NNS	denotes	QTL
T13631	18518-18528	RB	denotes	previously
T13632	18529-18539	VBN	denotes	identified
T13633	18539-18541	,	denotes	,
T13634	18541-18550	VBG	denotes	including
T13635	18551-18555	NNS	denotes	loci
T13636	18556-18557	CD	denotes	1
T13637	18557-18559	,	denotes	,
T13638	18559-18560	CD	denotes	2
T13639	18560-18562	,	denotes	,
T13640	18562-18563	CD	denotes	5
T13641	18564-18567	CC	denotes	and
T13642	18568-18569	CD	denotes	6
T13643	18569-18570	.	denotes	.
T13644	18570-18712	sentence	denotes	In addition, syntenic analysis revealed that the counterpart genomic regions on the human genome of many of these eight QTL are linked to RA.
T13645	18571-18573	IN	denotes	In
T13646	18602-18610	VBD	denotes	revealed
T13647	18574-18582	NN	denotes	addition
T13648	18582-18584	,	denotes	,
T13649	18584-18592	JJ	denotes	syntenic
T13650	18593-18601	NN	denotes	analysis
T13651	18611-18615	IN	denotes	that
T13652	18699-18705	VBN	denotes	linked
T13653	18616-18619	DT	denotes	the
T13654	18640-18647	NNS	denotes	regions
T13655	18620-18631	NN	denotes	counterpart
T13656	18632-18639	JJ	denotes	genomic
T13657	18648-18650	IN	denotes	on
T13658	18651-18654	DT	denotes	the
T13659	18661-18667	NN	denotes	genome
T13660	18655-18660	JJ	denotes	human
T13661	18668-18670	IN	denotes	of
T13662	18671-18675	JJ	denotes	many
T13663	18676-18678	IN	denotes	of
T13664	18679-18684	DT	denotes	these
T13665	18691-18694	NNS	denotes	QTL
T13666	18685-18690	CD	denotes	eight
T13667	18695-18698	VBP	denotes	are
T13668	18706-18708	IN	denotes	to
T13669	18709-18711	NN	denotes	RA
T13670	18711-18712	.	denotes	.
T13671	18712-18969	sentence	denotes	For five of the eight small-effect QTL the DBA/1 alleles are the arthritis-enhancing alleles, while the FVBN alleles are the arthritis-enhancing alleles in the other three QTL, indicating that some susceptibility genes could come from the resistant strain.
T13672	18713-18716	IN	denotes	For
T13673	18770-18773	VBP	denotes	are
T13674	18717-18721	CD	denotes	five
T13675	18729-18734	CD	denotes	eight
T13676	18722-18724	IN	denotes	of
T13677	18725-18728	DT	denotes	the
T13678	18748-18751	NNS	denotes	QTL
T13679	18735-18740	JJ	denotes	small
T13680	18741-18747	NN	denotes	effect
T13681	18740-18741	HYPH	denotes	-
T13682	18752-18755	DT	denotes	the
T13683	18762-18769	NNS	denotes	alleles
T13684	18756-18759	NN	denotes	DBA
T13685	18759-18760	HYPH	denotes	/
T13686	18760-18761	CD	denotes	1
T13687	18774-18777	DT	denotes	the
T13688	18798-18805	NNS	denotes	alleles
T13689	18778-18787	NN	denotes	arthritis
T13690	18788-18797	VBG	denotes	enhancing
T13691	18787-18788	HYPH	denotes	-
T13692	18805-18807	,	denotes	,
T13693	18807-18812	IN	denotes	while
T13694	18830-18833	VBP	denotes	are
T13695	18813-18816	DT	denotes	the
T13696	18822-18829	NNS	denotes	alleles
T13697	18817-18821	NN	denotes	FVBN
T13698	18834-18837	DT	denotes	the
T13699	18858-18865	NNS	denotes	alleles
T13700	18838-18847	NN	denotes	arthritis
T13701	18848-18857	VBG	denotes	enhancing
T13702	18847-18848	HYPH	denotes	-
T13703	18866-18868	IN	denotes	in
T13704	18869-18872	DT	denotes	the
T13705	18885-18888	NNS	denotes	QTL
T13706	18873-18878	JJ	denotes	other
T13707	18879-18884	CD	denotes	three
T13708	18888-18890	,	denotes	,
T13709	18890-18900	VBG	denotes	indicating
T13710	18901-18905	IN	denotes	that
T13711	18938-18942	VB	denotes	come
T13712	18906-18910	DT	denotes	some
T13713	18926-18931	NNS	denotes	genes
T13714	18911-18925	NN	denotes	susceptibility
T13715	18932-18937	MD	denotes	could
T13716	18943-18947	IN	denotes	from
T13717	18948-18951	DT	denotes	the
T13718	18962-18968	NN	denotes	strain
T13719	18952-18961	JJ	denotes	resistant
T13720	18968-18969	.	denotes	.
T13721	18969-19092	sentence	denotes	Interestingly, loci 2 and 7 partially overlap with two arthritis-related QTL identified by us in the same F2 progeny [10].
T13722	18970-18983	RB	denotes	Interestingly
T13723	19008-19015	VBP	denotes	overlap
T13724	18983-18985	,	denotes	,
T13725	18985-18989	NNS	denotes	loci
T13726	18990-18991	CD	denotes	2
T13727	18992-18995	CC	denotes	and
T13728	18996-18997	CD	denotes	7
T13729	18998-19007	RB	denotes	partially
T13730	19016-19020	IN	denotes	with
T13731	19021-19024	CD	denotes	two
T13732	19043-19046	NNS	denotes	QTL
T13733	19025-19034	NN	denotes	arthritis
T13734	19035-19042	VBN	denotes	related
T13735	19034-19035	HYPH	denotes	-
T13736	19047-19057	VBN	denotes	identified
T13737	19058-19060	IN	denotes	by
T13738	19061-19063	PRP	denotes	us
T13739	19064-19066	IN	denotes	in
T13740	19067-19070	DT	denotes	the
T13741	19079-19086	NN	denotes	progeny
T13742	19071-19075	JJ	denotes	same
T13743	19076-19078	NN	denotes	F2
T13744	19087-19088	-LRB-	denotes	[
T13745	19088-19090	CD	denotes	10
T13746	19090-19091	-RRB-	denotes	]
T13747	19091-19092	.	denotes	.
T13748	19092-19205	sentence	denotes	Locus 2 was located at the same genomic region as Cia27, a QTL controlling IgG2a antibody levels to collagen II.
T13749	19093-19098	NN	denotes	Locus
T13750	19105-19112	VBN	denotes	located
T13751	19099-19100	CD	denotes	2
T13752	19101-19104	VBD	denotes	was
T13753	19113-19115	IN	denotes	at
T13754	19116-19119	DT	denotes	the
T13755	19133-19139	NN	denotes	region
T13756	19120-19124	JJ	denotes	same
T13757	19125-19132	JJ	denotes	genomic
T13758	19140-19142	IN	denotes	as
T13759	19143-19148	NN	denotes	Cia27
T13760	19148-19150	,	denotes	,
T13761	19150-19151	DT	denotes	a
T13762	19152-19155	NN	denotes	QTL
T13763	19156-19167	VBG	denotes	controlling
T13764	19168-19173	NN	denotes	IgG2a
T13765	19183-19189	NNS	denotes	levels
T13766	19174-19182	NN	denotes	antibody
T13767	19190-19192	IN	denotes	to
T13768	19193-19201	NN	denotes	collagen
T13769	19202-19204	CD	denotes	II
T13770	19204-19205	.	denotes	.
T13771	19205-19396	sentence	denotes	Recently, we have refined this QTL into a 4.1 Mb genomic region and showed that a gene within this region regulates CIA severity by controlling the IgG2a antibody levels to collagen II [31].
T13772	19206-19214	RB	denotes	Recently
T13773	19224-19231	VBN	denotes	refined
T13774	19214-19216	,	denotes	,
T13775	19216-19218	PRP	denotes	we
T13776	19219-19223	VBP	denotes	have
T13777	19232-19236	DT	denotes	this
T13778	19237-19240	NN	denotes	QTL
T13779	19241-19245	IN	denotes	into
T13780	19246-19247	DT	denotes	a
T13781	19263-19269	NN	denotes	region
T13782	19248-19251	CD	denotes	4.1
T13783	19252-19254	NN	denotes	Mb
T13784	19255-19262	JJ	denotes	genomic
T13785	19270-19273	CC	denotes	and
T13786	19274-19280	VBD	denotes	showed
T13787	19281-19285	IN	denotes	that
T13788	19312-19321	VBZ	denotes	regulates
T13789	19286-19287	DT	denotes	a
T13790	19288-19292	NN	denotes	gene
T13791	19293-19299	IN	denotes	within
T13792	19300-19304	DT	denotes	this
T13793	19305-19311	NN	denotes	region
T13794	19322-19325	NN	denotes	CIA
T13795	19326-19334	NN	denotes	severity
T13796	19335-19337	IN	denotes	by
T13797	19338-19349	VBG	denotes	controlling
T13798	19350-19353	DT	denotes	the
T13799	19369-19375	NNS	denotes	levels
T13800	19354-19359	NN	denotes	IgG2a
T13801	19360-19368	NN	denotes	antibody
T13802	19376-19378	IN	denotes	to
T13803	19379-19387	NN	denotes	collagen
T13804	19388-19390	CD	denotes	II
T13805	19391-19392	-LRB-	denotes	[
T13806	19392-19394	CD	denotes	31
T13807	19394-19395	-RRB-	denotes	]
T13808	19395-19396	.	denotes	.
T13809	19396-19481	sentence	denotes	Locus 7 on chromosome 16 overlaps with Lp1, which controls lymphocyte proliferation.
T13810	19397-19402	NN	denotes	Locus
T13811	19422-19430	VBZ	denotes	overlaps
T13812	19403-19404	CD	denotes	7
T13813	19405-19407	IN	denotes	on
T13814	19408-19418	NN	denotes	chromosome
T13815	19419-19421	CD	denotes	16
T13816	19431-19435	IN	denotes	with
T13817	19436-19439	NN	denotes	Lp1
T13818	19439-19441	,	denotes	,
T13819	19441-19446	WDT	denotes	which
T13820	19447-19455	VBZ	denotes	controls
T13821	19456-19466	NN	denotes	lymphocyte
T13822	19467-19480	NN	denotes	proliferation
T13823	19480-19481	.	denotes	.
T13824	19481-19610	sentence	denotes	Furthermore, according to our unpublished data, loci 8 on chromosome 17 controls lymphocyte adherence during development of CIA.
T13825	19482-19493	RB	denotes	Furthermore
T13826	19554-19562	VBZ	denotes	controls
T13827	19493-19495	,	denotes	,
T13828	19495-19504	VBG	denotes	according
T13829	19505-19507	IN	denotes	to
T13830	19508-19511	PRP$	denotes	our
T13831	19524-19528	NNS	denotes	data
T13832	19512-19523	JJ	denotes	unpublished
T13833	19528-19530	,	denotes	,
T13834	19530-19534	NNS	denotes	loci
T13835	19535-19536	CD	denotes	8
T13836	19537-19539	IN	denotes	on
T13837	19540-19550	NN	denotes	chromosome
T13838	19551-19553	CD	denotes	17
T13839	19563-19573	NN	denotes	lymphocyte
T13840	19574-19583	NN	denotes	adherence
T13841	19584-19590	IN	denotes	during
T13842	19591-19602	NN	denotes	development
T13843	19603-19605	IN	denotes	of
T13844	19606-19609	NN	denotes	CIA
T13845	19609-19610	.	denotes	.
T13846	19610-19734	sentence	denotes	Therefore, the gene within the small-effect QTL could affect CIA severity through controlling arthritis-related phenotypes.
T13847	19611-19620	RB	denotes	Therefore
T13848	19665-19671	VB	denotes	affect
T13849	19620-19622	,	denotes	,
T13850	19622-19625	DT	denotes	the
T13851	19626-19630	NN	denotes	gene
T13852	19631-19637	IN	denotes	within
T13853	19638-19641	DT	denotes	the
T13854	19655-19658	NNS	denotes	QTL
T13855	19642-19647	JJ	denotes	small
T13856	19648-19654	NN	denotes	effect
T13857	19647-19648	HYPH	denotes	-
T13858	19659-19664	MD	denotes	could
T13859	19672-19675	NN	denotes	CIA
T13860	19676-19684	NN	denotes	severity
T13861	19685-19692	IN	denotes	through
T13862	19693-19704	VBG	denotes	controlling
T13863	19705-19714	NN	denotes	arthritis
T13864	19715-19722	VBN	denotes	related
T13865	19714-19715	HYPH	denotes	-
T13866	19723-19733	NNS	denotes	phenotypes
T13867	19733-19734	.	denotes	.
T13868	19734-19871	sentence	denotes	Several studies have been carried out to detect gene expression during CIA, all of which used joints as the target tissue [15,16,21,22].
T13869	19735-19742	JJ	denotes	Several
T13870	19743-19750	NNS	denotes	studies
T13871	19761-19768	VBN	denotes	carried
T13872	19751-19755	VBP	denotes	have
T13873	19756-19760	VBN	denotes	been
T13874	19769-19772	RP	denotes	out
T13875	19773-19775	TO	denotes	to
T13876	19776-19782	VB	denotes	detect
T13877	19783-19787	NN	denotes	gene
T13878	19788-19798	NN	denotes	expression
T13879	19799-19805	IN	denotes	during
T13880	19806-19809	NN	denotes	CIA
T13881	19809-19811	,	denotes	,
T13882	19811-19814	DT	denotes	all
T13883	19824-19828	VBD	denotes	used
T13884	19815-19817	IN	denotes	of
T13885	19818-19823	WDT	denotes	which
T13886	19829-19835	NNS	denotes	joints
T13887	19836-19838	IN	denotes	as
T13888	19839-19842	DT	denotes	the
T13889	19850-19856	NN	denotes	tissue
T13890	19843-19849	NN	denotes	target
T13891	19857-19858	-LRB-	denotes	[
T13892	19867-19869	CD	denotes	22
T13893	19858-19860	CD	denotes	15
T13894	19860-19861	,	denotes	,
T13895	19861-19863	CD	denotes	16
T13896	19863-19864	,	denotes	,
T13897	19864-19866	CD	denotes	21
T13898	19866-19867	,	denotes	,
T13899	19869-19870	-RRB-	denotes	]
T13900	19870-19871	.	denotes	.
T13901	19871-19947	sentence	denotes	This study, for the first time, detected gene expression in LNs during CIA.
T13902	19872-19876	DT	denotes	This
T13903	19877-19882	NN	denotes	study
T13904	19904-19912	VBD	denotes	detected
T13905	19882-19884	,	denotes	,
T13906	19884-19887	IN	denotes	for
T13907	19888-19891	DT	denotes	the
T13908	19898-19902	NN	denotes	time
T13909	19892-19897	JJ	denotes	first
T13910	19902-19904	,	denotes	,
T13911	19913-19917	NN	denotes	gene
T13912	19918-19928	NN	denotes	expression
T13913	19929-19931	IN	denotes	in
T13914	19932-19935	NNS	denotes	LNs
T13915	19936-19942	IN	denotes	during
T13916	19943-19946	NN	denotes	CIA
T13917	19946-19947	.	denotes	.
T13918	19947-20099	sentence	denotes	We present an extensive study of gene expression patterns in LNs of both genetically susceptible and resistant strains at four different phases of CIA.
T13919	19948-19950	PRP	denotes	We
T13920	19951-19958	VBP	denotes	present
T13921	19959-19961	DT	denotes	an
T13922	19972-19977	NN	denotes	study
T13923	19962-19971	JJ	denotes	extensive
T13924	19978-19980	IN	denotes	of
T13925	19981-19985	NN	denotes	gene
T13926	19997-20005	NNS	denotes	patterns
T13927	19986-19996	NN	denotes	expression
T13928	20006-20008	IN	denotes	in
T13929	20009-20012	NNS	denotes	LNs
T13930	20013-20015	IN	denotes	of
T13931	20016-20020	CC	denotes	both
T13932	20059-20066	NNS	denotes	strains
T13933	20021-20032	RB	denotes	genetically
T13934	20033-20044	JJ	denotes	susceptible
T13935	20045-20048	CC	denotes	and
T13936	20049-20058	JJ	denotes	resistant
T13937	20067-20069	IN	denotes	at
T13938	20070-20074	CD	denotes	four
T13939	20085-20091	NNS	denotes	phases
T13940	20075-20084	JJ	denotes	different
T13941	20092-20094	IN	denotes	of
T13942	20095-20098	NN	denotes	CIA
T13943	20098-20099	.	denotes	.
T13944	20099-20284	sentence	denotes	In both strains, differentially regulated genes were highly concentrated at the PI and CA phases, and only a small number of genes were differentially expressed in two or three phases.
T13945	20100-20102	IN	denotes	In
T13946	20148-20152	VBD	denotes	were
T13947	20103-20107	DT	denotes	both
T13948	20108-20115	NNS	denotes	strains
T13949	20115-20117	,	denotes	,
T13950	20117-20131	RB	denotes	differentially
T13951	20132-20141	VBN	denotes	regulated
T13952	20142-20147	NNS	denotes	genes
T13953	20153-20159	RB	denotes	highly
T13954	20160-20172	JJ	denotes	concentrated
T13955	20173-20175	IN	denotes	at
T13956	20176-20179	DT	denotes	the
T13957	20190-20196	NNS	denotes	phases
T13958	20180-20182	NN	denotes	PI
T13959	20183-20186	CC	denotes	and
T13960	20187-20189	NN	denotes	CA
T13961	20196-20198	,	denotes	,
T13962	20198-20201	CC	denotes	and
T13963	20202-20206	RB	denotes	only
T13964	20215-20221	NN	denotes	number
T13965	20207-20208	DT	denotes	a
T13966	20209-20214	JJ	denotes	small
T13967	20251-20260	VBN	denotes	expressed
T13968	20222-20224	IN	denotes	of
T13969	20225-20230	NNS	denotes	genes
T13970	20231-20235	VBD	denotes	were
T13971	20236-20250	RB	denotes	differentially
T13972	20261-20263	IN	denotes	in
T13973	20264-20267	CD	denotes	two
T13974	20277-20283	NNS	denotes	phases
T13975	20268-20270	CC	denotes	or
T13976	20271-20276	CD	denotes	three
T13977	20283-20284	.	denotes	.
T13978	20284-20446	sentence	denotes	This indicates that biological responses in LNs were stronger in the PI and CA phases than in the OA phase, and the responses at different phases were different.
T13979	20285-20289	DT	denotes	This
T13980	20290-20299	VBZ	denotes	indicates
T13981	20300-20304	IN	denotes	that
T13982	20333-20337	VBD	denotes	were
T13983	20305-20315	JJ	denotes	biological
T13984	20316-20325	NNS	denotes	responses
T13985	20326-20328	IN	denotes	in
T13986	20329-20332	NNS	denotes	LNs
T13987	20338-20346	JJR	denotes	stronger
T13988	20347-20349	IN	denotes	in
T13989	20350-20353	DT	denotes	the
T13990	20364-20370	NNS	denotes	phases
T13991	20354-20356	NN	denotes	PI
T13992	20357-20360	CC	denotes	and
T13993	20361-20363	NN	denotes	CA
T13994	20371-20375	IN	denotes	than
T13995	20376-20378	IN	denotes	in
T13996	20379-20382	DT	denotes	the
T13997	20386-20391	NN	denotes	phase
T13998	20383-20385	NN	denotes	OA
T13999	20391-20393	,	denotes	,
T14000	20393-20396	CC	denotes	and
T14001	20397-20400	DT	denotes	the
T14002	20401-20410	NNS	denotes	responses
T14003	20431-20435	VBD	denotes	were
T14004	20411-20413	IN	denotes	at
T14005	20414-20423	JJ	denotes	different
T14006	20424-20430	NNS	denotes	phases
T14007	20436-20445	JJ	denotes	different
T14008	20445-20446	.	denotes	.
T14009	20446-20583	sentence	denotes	When comparing the susceptible to the resistant strain, the biggest difference was found in one cluster of genes (cluster IV, Figure 2).
T14010	20447-20451	WRB	denotes	When
T14011	20452-20461	VBG	denotes	comparing
T14012	20530-20535	VBN	denotes	found
T14013	20462-20465	DT	denotes	the
T14014	20466-20477	JJ	denotes	susceptible
T14015	20478-20480	IN	denotes	to
T14016	20481-20484	DT	denotes	the
T14017	20485-20494	JJ	denotes	resistant
T14018	20495-20501	NN	denotes	strain
T14019	20501-20503	,	denotes	,
T14020	20503-20506	DT	denotes	the
T14021	20515-20525	NN	denotes	difference
T14022	20507-20514	JJS	denotes	biggest
T14023	20526-20529	VBD	denotes	was
T14024	20536-20538	IN	denotes	in
T14025	20539-20542	CD	denotes	one
T14026	20543-20550	NN	denotes	cluster
T14027	20551-20553	IN	denotes	of
T14028	20554-20559	NNS	denotes	genes
T14029	20560-20561	-LRB-	denotes	(
T14030	20561-20568	NN	denotes	cluster
T14031	20569-20571	CD	denotes	IV
T14032	20571-20573	,	denotes	,
T14033	20573-20579	NN	denotes	Figure
T14034	20580-20581	CD	denotes	2
T14035	20581-20582	-RRB-	denotes	)
T14036	20582-20583	.	denotes	.
T14037	20583-20738	sentence	denotes	These genes had a higher expression in DBA/1 than in FVB/N at the early phases of CIA (NC, PI and OA) and the opposite expression pattern in the CA phase.
T14038	20584-20589	DT	denotes	These
T14039	20590-20595	NNS	denotes	genes
T14040	20596-20599	VBD	denotes	had
T14041	20600-20601	DT	denotes	a
T14042	20609-20619	NN	denotes	expression
T14043	20602-20608	JJR	denotes	higher
T14044	20620-20622	IN	denotes	in
T14045	20623-20626	NN	denotes	DBA
T14046	20626-20627	HYPH	denotes	/
T14047	20627-20628	CD	denotes	1
T14048	20629-20633	IN	denotes	than
T14049	20634-20636	IN	denotes	in
T14050	20637-20640	NN	denotes	FVB
T14051	20641-20642	NN	denotes	N
T14052	20640-20641	HYPH	denotes	/
T14053	20643-20645	IN	denotes	at
T14054	20646-20649	DT	denotes	the
T14055	20656-20662	NNS	denotes	phases
T14056	20650-20655	JJ	denotes	early
T14057	20663-20665	IN	denotes	of
T14058	20666-20669	NN	denotes	CIA
T14059	20670-20671	-LRB-	denotes	(
T14060	20671-20673	NN	denotes	NC
T14061	20673-20675	,	denotes	,
T14062	20675-20677	NN	denotes	PI
T14063	20678-20681	CC	denotes	and
T14064	20682-20684	NN	denotes	OA
T14065	20684-20685	-RRB-	denotes	)
T14066	20686-20689	CC	denotes	and
T14067	20690-20693	DT	denotes	the
T14068	20714-20721	NN	denotes	pattern
T14069	20694-20702	JJ	denotes	opposite
T14070	20703-20713	NN	denotes	expression
T14071	20722-20724	IN	denotes	in
T14072	20725-20728	DT	denotes	the
T14073	20732-20737	NN	denotes	phase
T14074	20729-20731	NN	denotes	CA
T14075	20737-20738	.	denotes	.
T14076	20738-20943	sentence	denotes	GO term classification revealed that these genes were related to lymphocyte proliferation and activation, suggesting that lymphocytes in the DBA/1 strain are more activated than those in the FVB/N strain.
T14077	20739-20741	NN	denotes	GO
T14078	20747-20761	NN	denotes	classification
T14079	20742-20746	NN	denotes	term
T14080	20762-20770	VBD	denotes	revealed
T14081	20771-20775	IN	denotes	that
T14082	20793-20800	VBN	denotes	related
T14083	20776-20781	DT	denotes	these
T14084	20782-20787	NNS	denotes	genes
T14085	20788-20792	VBD	denotes	were
T14086	20801-20803	IN	denotes	to
T14087	20804-20814	NN	denotes	lymphocyte
T14088	20815-20828	NN	denotes	proliferation
T14089	20829-20832	CC	denotes	and
T14090	20833-20843	NN	denotes	activation
T14091	20843-20845	,	denotes	,
T14092	20845-20855	VBG	denotes	suggesting
T14093	20856-20860	IN	denotes	that
T14094	20893-20896	VBP	denotes	are
T14095	20861-20872	NNS	denotes	lymphocytes
T14096	20873-20875	IN	denotes	in
T14097	20876-20879	DT	denotes	the
T14098	20886-20892	NN	denotes	strain
T14099	20880-20883	NN	denotes	DBA
T14100	20883-20884	HYPH	denotes	/
T14101	20884-20885	CD	denotes	1
T14102	20897-20901	RBR	denotes	more
T14103	20902-20911	JJ	denotes	activated
T14104	20912-20916	IN	denotes	than
T14105	20917-20922	DT	denotes	those
T14106	20923-20925	IN	denotes	in
T14107	20926-20929	DT	denotes	the
T14108	20936-20942	NN	denotes	strain
T14109	20930-20933	NN	denotes	FVB
T14110	20934-20935	NN	denotes	N
T14111	20933-20934	HYPH	denotes	/
T14112	20942-20943	.	denotes	.
T14113	20943-21084	sentence	denotes	However, this difference is not CIA specific because the expression difference between the two strains existed in mice without immunisation.
T14114	20944-20951	RB	denotes	However
T14115	20969-20971	VBZ	denotes	is
T14116	20951-20953	,	denotes	,
T14117	20953-20957	DT	denotes	this
T14118	20958-20968	NN	denotes	difference
T14119	20972-20975	RB	denotes	not
T14120	20976-20979	NN	denotes	CIA
T14121	20980-20988	JJ	denotes	specific
T14122	20989-20996	IN	denotes	because
T14123	21047-21054	VBD	denotes	existed
T14124	20997-21000	DT	denotes	the
T14125	21012-21022	NN	denotes	difference
T14126	21001-21011	NN	denotes	expression
T14127	21023-21030	IN	denotes	between
T14128	21031-21034	DT	denotes	the
T14129	21039-21046	NNS	denotes	strains
T14130	21035-21038	CD	denotes	two
T14131	21055-21057	IN	denotes	in
T14132	21058-21062	NNS	denotes	mice
T14133	21063-21070	IN	denotes	without
T14134	21071-21083	NN	denotes	immunisation
T14135	21083-21084	.	denotes	.
T14136	21084-21217	sentence	denotes	Additionally, some genes related to the immune response were upregulated in the DBA/1 strain but not in the FVB/N strain during CIA.
T14137	21085-21097	RB	denotes	Additionally
T14138	21146-21157	VBN	denotes	upregulated
T14139	21097-21099	,	denotes	,
T14140	21099-21103	DT	denotes	some
T14141	21104-21109	NNS	denotes	genes
T14142	21110-21117	VBN	denotes	related
T14143	21118-21120	IN	denotes	to
T14144	21121-21124	DT	denotes	the
T14145	21132-21140	NN	denotes	response
T14146	21125-21131	JJ	denotes	immune
T14147	21141-21145	VBD	denotes	were
T14148	21158-21160	IN	denotes	in
T14149	21161-21164	DT	denotes	the
T14150	21171-21177	NN	denotes	strain
T14151	21165-21168	NN	denotes	DBA
T14152	21168-21169	HYPH	denotes	/
T14153	21169-21170	CD	denotes	1
T14154	21178-21181	CC	denotes	but
T14155	21182-21185	RB	denotes	not
T14156	21186-21188	IN	denotes	in
T14157	21189-21192	DT	denotes	the
T14158	21199-21205	NN	denotes	strain
T14159	21193-21196	NN	denotes	FVB
T14160	21197-21198	NN	denotes	N
T14161	21196-21197	HYPH	denotes	/
T14162	21206-21212	IN	denotes	during
T14163	21213-21216	NN	denotes	CIA
T14164	21216-21217	.	denotes	.
T14165	21217-21448	sentence	denotes	These differences could explain why a higher antibody response to collagen II occurred in the DBA/1 strain compared to the FVB/N strain, and might partially explain the difference of the susceptibility to CIA between both strains.
T14166	21218-21223	DT	denotes	These
T14167	21224-21235	NNS	denotes	differences
T14168	21242-21249	VB	denotes	explain
T14169	21236-21241	MD	denotes	could
T14170	21250-21253	WRB	denotes	why
T14171	21296-21304	VBD	denotes	occurred
T14172	21254-21255	DT	denotes	a
T14173	21272-21280	NN	denotes	response
T14174	21256-21262	JJR	denotes	higher
T14175	21263-21271	NN	denotes	antibody
T14176	21281-21283	IN	denotes	to
T14177	21284-21292	NN	denotes	collagen
T14178	21293-21295	CD	denotes	II
T14179	21305-21307	IN	denotes	in
T14180	21308-21311	DT	denotes	the
T14181	21318-21324	NN	denotes	strain
T14182	21312-21315	NN	denotes	DBA
T14183	21315-21316	HYPH	denotes	/
T14184	21316-21317	CD	denotes	1
T14185	21325-21333	VBN	denotes	compared
T14186	21334-21336	IN	denotes	to
T14187	21337-21340	DT	denotes	the
T14188	21347-21353	NN	denotes	strain
T14189	21341-21344	NN	denotes	FVB
T14190	21345-21346	NN	denotes	N
T14191	21344-21345	HYPH	denotes	/
T14192	21353-21355	,	denotes	,
T14193	21355-21358	CC	denotes	and
T14194	21359-21364	MD	denotes	might
T14195	21375-21382	VB	denotes	explain
T14196	21365-21374	RB	denotes	partially
T14197	21383-21386	DT	denotes	the
T14198	21387-21397	NN	denotes	difference
T14199	21398-21400	IN	denotes	of
T14200	21401-21404	DT	denotes	the
T14201	21405-21419	NN	denotes	susceptibility
T14202	21420-21422	IN	denotes	to
T14203	21423-21426	NN	denotes	CIA
T14204	21427-21434	IN	denotes	between
T14205	21435-21439	DT	denotes	both
T14206	21440-21447	NNS	denotes	strains
T14207	21447-21448	.	denotes	.
T14208	21448-21632	sentence	denotes	Twenty-one genes were identified as potential candidate genes for six of the eight small-effect QTL according to their gene expression patterns during CIA and their genomic locations.
T14209	21449-21455	CD	denotes	Twenty
T14210	21456-21459	CD	denotes	one
T14211	21455-21456	HYPH	denotes	-
T14212	21460-21465	NNS	denotes	genes
T14213	21471-21481	VBN	denotes	identified
T14214	21466-21470	VBD	denotes	were
T14215	21482-21484	IN	denotes	as
T14216	21485-21494	JJ	denotes	potential
T14217	21505-21510	NNS	denotes	genes
T14218	21495-21504	NN	denotes	candidate
T14219	21511-21514	IN	denotes	for
T14220	21515-21518	CD	denotes	six
T14221	21526-21531	CD	denotes	eight
T14222	21519-21521	IN	denotes	of
T14223	21522-21525	DT	denotes	the
T14224	21545-21548	NNS	denotes	QTL
T14225	21532-21537	JJ	denotes	small
T14226	21538-21544	NN	denotes	effect
T14227	21537-21538	HYPH	denotes	-
T14228	21549-21558	VBG	denotes	according
T14229	21559-21561	IN	denotes	to
T14230	21562-21567	PRP$	denotes	their
T14231	21584-21592	NNS	denotes	patterns
T14232	21568-21572	NN	denotes	gene
T14233	21573-21583	NN	denotes	expression
T14234	21593-21599	IN	denotes	during
T14235	21600-21603	NN	denotes	CIA
T14236	21604-21607	CC	denotes	and
T14237	21608-21613	PRP$	denotes	their
T14238	21622-21631	NNS	denotes	locations
T14239	21614-21621	JJ	denotes	genomic
T14240	21631-21632	.	denotes	.
T14241	21632-21825	sentence	denotes	No candidate genes were located in QTL 4 and 7, suggesting that QTG polymorphisms of the susceptibility genes inside these two QTL might not affect the phenotype by regulating gene expression.
T14242	21633-21635	DT	denotes	No
T14243	21646-21651	NNS	denotes	genes
T14244	21636-21645	NN	denotes	candidate
T14245	21657-21664	VBN	denotes	located
T14246	21652-21656	VBD	denotes	were
T14247	21665-21667	IN	denotes	in
T14248	21668-21671	NNS	denotes	QTL
T14249	21672-21673	CD	denotes	4
T14250	21674-21677	CC	denotes	and
T14251	21678-21679	CD	denotes	7
T14252	21679-21681	,	denotes	,
T14253	21681-21691	VBG	denotes	suggesting
T14254	21692-21696	IN	denotes	that
T14255	21774-21780	VB	denotes	affect
T14256	21697-21700	NN	denotes	QTG
T14257	21701-21714	NNS	denotes	polymorphisms
T14258	21715-21717	IN	denotes	of
T14259	21718-21721	DT	denotes	the
T14260	21737-21742	NNS	denotes	genes
T14261	21722-21736	NN	denotes	susceptibility
T14262	21743-21749	IN	denotes	inside
T14263	21750-21755	DT	denotes	these
T14264	21760-21763	NNS	denotes	QTL
T14265	21756-21759	CD	denotes	two
T14266	21764-21769	MD	denotes	might
T14267	21770-21773	RB	denotes	not
T14268	21781-21784	DT	denotes	the
T14269	21785-21794	NN	denotes	phenotype
T14270	21795-21797	IN	denotes	by
T14271	21798-21808	VBG	denotes	regulating
T14272	21809-21813	NN	denotes	gene
T14273	21814-21824	NN	denotes	expression
T14274	21824-21825	.	denotes	.
T14275	21825-21898	sentence	denotes	Two of the 21 candidate genes were reported to be involved in arthritis.
T14276	21826-21829	CD	denotes	Two
T14277	21837-21839	CD	denotes	21
T14278	21830-21832	IN	denotes	of
T14279	21833-21836	DT	denotes	the
T14280	21850-21855	NNS	denotes	genes
T14281	21840-21849	NN	denotes	candidate
T14282	21861-21869	VBN	denotes	reported
T14283	21856-21860	VBD	denotes	were
T14284	21870-21872	TO	denotes	to
T14285	21876-21884	VBN	denotes	involved
T14286	21873-21875	VB	denotes	be
T14287	21885-21887	IN	denotes	in
T14288	21888-21897	NN	denotes	arthritis
T14289	21897-21898	.	denotes	.
T14290	21898-22116	sentence	denotes	Mapk14, a candidate gene for locus 8 and also called p38 mitogen-activated protein kinase (MAPK) alpha, regulates the production of arthritis-essential cytokines, such as tumour necrosis factor and interleukin-1 [32].
T14291	21899-21905	NN	denotes	Mapk14
T14292	22003-22012	VBZ	denotes	regulates
T14293	21905-21907	,	denotes	,
T14294	21907-21908	DT	denotes	a
T14295	21919-21923	NN	denotes	gene
T14296	21909-21918	NN	denotes	candidate
T14297	21924-21927	IN	denotes	for
T14298	21928-21933	NN	denotes	locus
T14299	21934-21935	CD	denotes	8
T14300	21936-21939	CC	denotes	and
T14301	21940-21944	RB	denotes	also
T14302	21945-21951	VBN	denotes	called
T14303	21952-21955	NN	denotes	p38
T14304	21982-21988	NN	denotes	kinase
T14305	21956-21963	NN	denotes	mitogen
T14306	21964-21973	VBN	denotes	activated
T14307	21963-21964	HYPH	denotes	-
T14308	21974-21981	NN	denotes	protein
T14309	21996-22001	NN	denotes	alpha
T14310	21989-21990	-LRB-	denotes	(
T14311	21990-21994	NN	denotes	MAPK
T14312	21994-21995	-RRB-	denotes	)
T14313	22001-22003	,	denotes	,
T14314	22013-22016	DT	denotes	the
T14315	22017-22027	NN	denotes	production
T14316	22028-22030	IN	denotes	of
T14317	22031-22040	NN	denotes	arthritis
T14318	22041-22050	JJ	denotes	essential
T14319	22040-22041	HYPH	denotes	-
T14320	22051-22060	NNS	denotes	cytokines
T14321	22060-22062	,	denotes	,
T14322	22062-22066	JJ	denotes	such
T14323	22067-22069	IN	denotes	as
T14324	22070-22076	NN	denotes	tumour
T14325	22086-22092	NN	denotes	factor
T14326	22077-22085	NN	denotes	necrosis
T14327	22093-22096	CC	denotes	and
T14328	22097-22108	NN	denotes	interleukin
T14329	22108-22109	HYPH	denotes	-
T14330	22109-22110	CD	denotes	1
T14331	22111-22112	-LRB-	denotes	[
T14332	22112-22114	CD	denotes	32
T14333	22114-22115	-RRB-	denotes	]
T14334	22115-22116	.	denotes	.
T14335	22116-22251	sentence	denotes	Moreover, inhibitors of p38 MAPK could attenuate CIA in rats [33], and p38 MAPK is becoming a potential therapeutic target in RA [32].
T14336	22117-22125	RB	denotes	Moreover
T14337	22156-22165	VB	denotes	attenuate
T14338	22125-22127	,	denotes	,
T14339	22127-22137	NNS	denotes	inhibitors
T14340	22138-22140	IN	denotes	of
T14341	22141-22144	NN	denotes	p38
T14342	22145-22149	NN	denotes	MAPK
T14343	22150-22155	MD	denotes	could
T14344	22166-22169	NN	denotes	CIA
T14345	22170-22172	IN	denotes	in
T14346	22173-22177	NNS	denotes	rats
T14347	22178-22179	-LRB-	denotes	[
T14348	22179-22181	CD	denotes	33
T14349	22181-22182	-RRB-	denotes	]
T14350	22182-22184	,	denotes	,
T14351	22184-22187	CC	denotes	and
T14352	22188-22191	NN	denotes	p38
T14353	22192-22196	NN	denotes	MAPK
T14354	22200-22208	VBG	denotes	becoming
T14355	22197-22199	VBZ	denotes	is
T14356	22209-22210	DT	denotes	a
T14357	22233-22239	NN	denotes	target
T14358	22211-22220	JJ	denotes	potential
T14359	22221-22232	JJ	denotes	therapeutic
T14360	22240-22242	IN	denotes	in
T14361	22243-22245	NN	denotes	RA
T14362	22246-22247	-LRB-	denotes	[
T14363	22247-22249	CD	denotes	32
T14364	22249-22250	-RRB-	denotes	]
T14365	22250-22251	.	denotes	.
T14366	22251-22364	sentence	denotes	Stat5a, a candidate gene for loci 6, is an essential molecule for lymphoid development and differentiation [34].
T14367	22252-22258	NN	denotes	Stat5a
T14368	22289-22291	VBZ	denotes	is
T14369	22258-22260	,	denotes	,
T14370	22260-22261	DT	denotes	a
T14371	22272-22276	NN	denotes	gene
T14372	22262-22271	NN	denotes	candidate
T14373	22277-22280	IN	denotes	for
T14374	22281-22285	NNS	denotes	loci
T14375	22286-22287	CD	denotes	6
T14376	22287-22289	,	denotes	,
T14377	22292-22294	DT	denotes	an
T14378	22305-22313	NN	denotes	molecule
T14379	22295-22304	JJ	denotes	essential
T14380	22314-22317	IN	denotes	for
T14381	22318-22326	NN	denotes	lymphoid
T14382	22327-22338	NN	denotes	development
T14383	22339-22342	CC	denotes	and
T14384	22343-22358	NN	denotes	differentiation
T14385	22359-22360	-LRB-	denotes	[
T14386	22360-22362	CD	denotes	34
T14387	22362-22363	-RRB-	denotes	]
T14388	22363-22364	.	denotes	.
T14389	22364-22472	sentence	denotes	Stat5a-deficient mice were reported to lose tolerance, resulting in the development of autoimmune diseases.
T14390	22365-22371	NN	denotes	Stat5a
T14391	22372-22381	JJ	denotes	deficient
T14392	22371-22372	HYPH	denotes	-
T14393	22382-22386	NNS	denotes	mice
T14394	22392-22400	VBN	denotes	reported
T14395	22387-22391	VBD	denotes	were
T14396	22401-22403	TO	denotes	to
T14397	22404-22408	VB	denotes	lose
T14398	22409-22418	NN	denotes	tolerance
T14399	22418-22420	,	denotes	,
T14400	22420-22429	VBG	denotes	resulting
T14401	22430-22432	IN	denotes	in
T14402	22433-22436	DT	denotes	the
T14403	22437-22448	NN	denotes	development
T14404	22449-22451	IN	denotes	of
T14405	22452-22462	JJ	denotes	autoimmune
T14406	22463-22471	NNS	denotes	diseases
T14407	22471-22472	.	denotes	.
T14408	22472-22591	sentence	denotes	Stat5a is suggested to contribute to tolerance through maintenance of the CD4+CD25+ regulatory T cell population [35].
T14409	22473-22479	NN	denotes	Stat5a
T14410	22483-22492	VBN	denotes	suggested
T14411	22480-22482	VBZ	denotes	is
T14412	22493-22495	TO	denotes	to
T14413	22496-22506	VB	denotes	contribute
T14414	22507-22509	IN	denotes	to
T14415	22510-22519	NN	denotes	tolerance
T14416	22520-22527	IN	denotes	through
T14417	22528-22539	NN	denotes	maintenance
T14418	22540-22542	IN	denotes	of
T14419	22543-22546	DT	denotes	the
T14420	22575-22585	NN	denotes	population
T14421	22547-22556	NN	denotes	CD4+CD25+
T14422	22557-22567	JJ	denotes	regulatory
T14423	22568-22569	NN	denotes	T
T14424	22570-22574	NN	denotes	cell
T14425	22586-22587	-LRB-	denotes	[
T14426	22587-22589	CD	denotes	35
T14427	22589-22590	-RRB-	denotes	]
T14428	22590-22591	.	denotes	.
T14429	22591-22714	sentence	denotes	Therefore, we have presented a strategy to identify small-effect QTL and search for potential candidate genes within them.
T14430	22592-22601	RB	denotes	Therefore
T14431	22611-22620	VBN	denotes	presented
T14432	22601-22603	,	denotes	,
T14433	22603-22605	PRP	denotes	we
T14434	22606-22610	VBP	denotes	have
T14435	22621-22622	DT	denotes	a
T14436	22623-22631	NN	denotes	strategy
T14437	22632-22634	TO	denotes	to
T14438	22635-22643	VB	denotes	identify
T14439	22644-22649	JJ	denotes	small
T14440	22650-22656	NN	denotes	effect
T14441	22649-22650	HYPH	denotes	-
T14442	22657-22660	NNS	denotes	QTL
T14443	22661-22664	CC	denotes	and
T14444	22665-22671	VB	denotes	search
T14445	22672-22675	IN	denotes	for
T14446	22676-22685	JJ	denotes	potential
T14447	22696-22701	NNS	denotes	genes
T14448	22686-22695	NN	denotes	candidate
T14449	22702-22708	IN	denotes	within
T14450	22709-22713	PRP	denotes	them
T14451	22713-22714	.	denotes	.
T14452	22714-22856	sentence	denotes	However, it is noteworthy that the low statistical threshold and small number of animals per group could lead to some false positive results.
T14453	22715-22722	RB	denotes	However
T14454	22727-22729	VBZ	denotes	is
T14455	22722-22724	,	denotes	,
T14456	22724-22726	PRP	denotes	it
T14457	22730-22740	JJ	denotes	noteworthy
T14458	22741-22745	IN	denotes	that
T14459	22820-22824	VB	denotes	lead
T14460	22746-22749	DT	denotes	the
T14461	22766-22775	NN	denotes	threshold
T14462	22750-22753	JJ	denotes	low
T14463	22754-22765	JJ	denotes	statistical
T14464	22776-22779	CC	denotes	and
T14465	22780-22785	JJ	denotes	small
T14466	22786-22792	NN	denotes	number
T14467	22793-22795	IN	denotes	of
T14468	22796-22803	NNS	denotes	animals
T14469	22804-22807	IN	denotes	per
T14470	22808-22813	NN	denotes	group
T14471	22814-22819	MD	denotes	could
T14472	22825-22827	IN	denotes	to
T14473	22828-22832	DT	denotes	some
T14474	22848-22855	NNS	denotes	results
T14475	22833-22838	JJ	denotes	false
T14476	22839-22847	JJ	denotes	positive
T14477	22855-22856	.	denotes	.
T14478	22856-22993	sentence	denotes	On the genome level, some of the eight small-effect QTL identified using a very low threshold value (P < 0.05) could be false positives.
T14479	22857-22859	IN	denotes	On
T14480	22974-22976	VB	denotes	be
T14481	22860-22863	DT	denotes	the
T14482	22871-22876	NN	denotes	level
T14483	22864-22870	NN	denotes	genome
T14484	22876-22878	,	denotes	,
T14485	22878-22882	DT	denotes	some
T14486	22883-22885	IN	denotes	of
T14487	22886-22889	DT	denotes	the
T14488	22909-22912	NNS	denotes	QTL
T14489	22890-22895	CD	denotes	eight
T14490	22896-22901	JJ	denotes	small
T14491	22902-22908	NN	denotes	effect
T14492	22901-22902	HYPH	denotes	-
T14493	22913-22923	VBN	denotes	identified
T14494	22924-22929	VBG	denotes	using
T14495	22930-22931	DT	denotes	a
T14496	22951-22956	NN	denotes	value
T14497	22932-22936	RB	denotes	very
T14498	22937-22940	JJ	denotes	low
T14499	22941-22950	NN	denotes	threshold
T14500	22957-22958	-LRB-	denotes	(
T14501	22962-22966	CD	denotes	0.05
T14502	22958-22959	NN	denotes	P
T14503	22960-22961	SYM	denotes	<
T14504	22966-22967	-RRB-	denotes	)
T14505	22968-22973	MD	denotes	could
T14506	22977-22982	JJ	denotes	false
T14507	22983-22992	NNS	denotes	positives
T14508	22992-22993	.	denotes	.
T14509	22993-23115	sentence	denotes	For example, locus 4 was identified with a low P value and does not overlap with any previously identified arthritis QTL.
T14510	22994-22997	IN	denotes	For
T14511	23019-23029	VBN	denotes	identified
T14512	22998-23005	NN	denotes	example
T14513	23005-23007	,	denotes	,
T14514	23007-23012	NN	denotes	locus
T14515	23013-23014	CD	denotes	4
T14516	23015-23018	VBD	denotes	was
T14517	23030-23034	IN	denotes	with
T14518	23035-23036	DT	denotes	a
T14519	23043-23048	NN	denotes	value
T14520	23037-23040	JJ	denotes	low
T14521	23041-23042	NN	denotes	P
T14522	23049-23052	CC	denotes	and
T14523	23053-23057	VBZ	denotes	does
T14524	23062-23069	VB	denotes	overlap
T14525	23058-23061	RB	denotes	not
T14526	23070-23074	IN	denotes	with
T14527	23075-23078	DT	denotes	any
T14528	23111-23114	NNS	denotes	QTL
T14529	23079-23089	RB	denotes	previously
T14530	23090-23100	VBN	denotes	identified
T14531	23101-23110	NN	denotes	arthritis
T14532	23114-23115	.	denotes	.
T14533	23115-23310	sentence	denotes	On the transcriptome level, the small number of animals per group and the low threshold used to detect gene expression could also result in false positives in the differentially expressed genes.
T14534	23116-23118	IN	denotes	On
T14535	23246-23252	VB	denotes	result
T14536	23119-23122	DT	denotes	the
T14537	23137-23142	NN	denotes	level
T14538	23123-23136	NN	denotes	transcriptome
T14539	23142-23144	,	denotes	,
T14540	23144-23147	DT	denotes	the
T14541	23154-23160	NN	denotes	number
T14542	23148-23153	JJ	denotes	small
T14543	23161-23163	IN	denotes	of
T14544	23164-23171	NNS	denotes	animals
T14545	23172-23175	IN	denotes	per
T14546	23176-23181	NN	denotes	group
T14578	23375-23378	RB	denotes	not
T14579	23384-23388	IN	denotes	from
T14580	23379-23383	RB	denotes	only
T14581	23389-23395	NN	denotes	allele
T14582	23396-23406	NN	denotes	difference
T14583	23407-23414	IN	denotes	between
T14584	23415-23418	CD	denotes	two
T14585	23419-23426	NNS	denotes	strains
T14586	23426-23428	,	denotes	,
T14587	23428-23431	CC	denotes	but
T14588	23432-23436	RB	denotes	also
T14589	23437-23441	IN	denotes	from
T14590	23442-23447	JJ	denotes	other
T14591	23448-23455	NNS	denotes	factors
T14592	23455-23456	.	denotes	.
T14593	23456-23519	sentence	denotes	Therefore, our findings should be confirmed in future studies.
T14594	23457-23466	RB	denotes	Therefore
T14595	23491-23500	VBN	denotes	confirmed
T14596	23466-23468	,	denotes	,
T14597	23468-23471	PRP$	denotes	our
T14598	23472-23480	NNS	denotes	findings
T14599	23481-23487	MD	denotes	should
T14600	23488-23490	VB	denotes	be
T14601	23501-23503	IN	denotes	in
T14602	23504-23510	JJ	denotes	future
T14603	23511-23518	NNS	denotes	studies
T14604	23518-23519	.	denotes	.
T14922	23532-23534	PRP	denotes	We
T14923	23535-23542	VBP	denotes	present
T14924	23543-23544	DT	denotes	a
T14925	23545-23553	NN	denotes	strategy
T14926	23554-23556	TO	denotes	to
T14927	23557-23563	VB	denotes	search
T14928	23564-23573	NN	denotes	candidate
T14929	23574-23579	NNS	denotes	genes
T14930	23580-23583	IN	denotes	for
T14931	23584-23589	JJ	denotes	small
T14932	23590-23596	NN	denotes	effect
T14933	23589-23590	HYPH	denotes	-
T14934	23597-23600	NNS	denotes	QTL
T14935	23600-23601	.	denotes	.
T14936	23601-23708	sentence	denotes	With this strategy, we identified 21 candidate genes for 8 small-effect QTL regulating CIA susceptibility.
T14937	23602-23606	IN	denotes	With
T14938	23625-23635	VBD	denotes	identified
T14939	23607-23611	DT	denotes	this
T14940	23612-23620	NN	denotes	strategy
T14941	23620-23622	,	denotes	,
T14942	23622-23624	PRP	denotes	we
T14943	23636-23638	CD	denotes	21
T14944	23649-23654	NNS	denotes	genes
T14945	23639-23648	NN	denotes	candidate
T14946	23655-23658	IN	denotes	for
T14947	23659-23660	CD	denotes	8
T14948	23693-23707	NN	denotes	susceptibility
T14949	23661-23666	JJ	denotes	small
T14950	23667-23673	NN	denotes	effect
T14951	23666-23667	HYPH	denotes	-
T14952	23674-23677	NNS	denotes	QTL
T14953	23678-23688	VBG	denotes	regulating
T14954	23689-23692	NN	denotes	CIA
T14955	23707-23708	.	denotes	.
T14956	23708-23769	sentence	denotes	Our future studies will be carried out using two approaches.
T14957	23709-23712	PRP$	denotes	Our
T14958	23720-23727	NNS	denotes	studies
T14959	23713-23719	JJ	denotes	future
T14960	23736-23743	VBN	denotes	carried
T14961	23728-23732	MD	denotes	will
T14962	23733-23735	VB	denotes	be
T14963	23744-23747	RP	denotes	out
T14964	23748-23753	VBG	denotes	using
T14965	23754-23757	CD	denotes	two
T14966	23758-23768	NNS	denotes	approaches
T14967	23768-23769	.	denotes	.
T14968	23769-23930	sentence	denotes	The first is generating congenic animals for promising small-effect QTL that have relatively high P values and overlap with previously-identified arthritis QTL.
T14969	23770-23773	DT	denotes	The
T14970	23774-23779	JJ	denotes	first
T14971	23783-23793	VBG	denotes	generating
T14972	23780-23782	VBZ	denotes	is
T14973	23794-23802	JJ	denotes	congenic
T14974	23803-23810	NNS	denotes	animals
T14975	23811-23814	IN	denotes	for
T14976	23815-23824	VBG	denotes	promising
T14977	23838-23841	NNS	denotes	QTL
T14978	23825-23830	JJ	denotes	small
T14979	23831-23837	NN	denotes	effect
T14980	23830-23831	HYPH	denotes	-
T14981	23842-23846	WDT	denotes	that
T14982	23847-23851	VBP	denotes	have
T14983	23852-23862	RB	denotes	relatively
T14984	23863-23867	JJ	denotes	high
T14985	23870-23876	NNS	denotes	values
T14986	23868-23869	NN	denotes	P
T14987	23877-23880	CC	denotes	and
T14988	23881-23888	VBP	denotes	overlap
T14989	23889-23893	IN	denotes	with
T14990	23894-23904	RB	denotes	previously
T14991	23905-23915	VBN	denotes	identified
T14992	23904-23905	HYPH	denotes	-
T14993	23926-23929	NNS	denotes	QTL
T14994	23916-23925	NN	denotes	arthritis
T14995	23929-23930	.	denotes	.
T14996	23930-24019	sentence	denotes	The second approach is investigating candidate genes using both mouse and human studies.
T14997	23931-23934	DT	denotes	The
T14998	23942-23950	NN	denotes	approach
T14999	23935-23941	JJ	denotes	second
T15000	23951-23953	VBZ	denotes	is
T15001	23954-23967	VBG	denotes	investigating
T15002	23968-23977	NN	denotes	candidate
T15003	23978-23983	NNS	denotes	genes
T15004	23984-23989	VBG	denotes	using
T15005	23990-23994	CC	denotes	both
T15006	23995-24000	NN	denotes	mouse
T15007	24011-24018	NNS	denotes	studies
T15008	24001-24004	CC	denotes	and
T15009	24005-24010	JJ	denotes	human
T15010	24018-24019	.	denotes	.
T15011	24019-24122	sentence	denotes	Candidate genes will be selected according to their function and polymorphism between the two strains.
T15012	24020-24029	NN	denotes	Candidate
T15013	24030-24035	NNS	denotes	genes
T15014	24044-24052	VBN	denotes	selected
T15015	24036-24040	MD	denotes	will
T15016	24041-24043	VB	denotes	be
T15017	24053-24062	VBG	denotes	according
T15018	24063-24065	IN	denotes	to
T15019	24066-24071	PRP$	denotes	their
T15020	24072-24080	NN	denotes	function
T15021	24081-24084	CC	denotes	and
T15022	24085-24097	NN	denotes	polymorphism
T15023	24098-24105	IN	denotes	between
T15024	24106-24109	DT	denotes	the
T15025	24114-24121	NNS	denotes	strains
T15026	24110-24113	CD	denotes	two
T15027	24121-24122	.	denotes	.
T15028	24122-24211	sentence	denotes	Thereafter, we will generate knock-out mice to investigate the role of the genes in CIA.
T15029	24123-24133	RB	denotes	Thereafter
T15030	24143-24151	VB	denotes	generate
T15031	24133-24135	,	denotes	,
T15032	24135-24137	PRP	denotes	we
T15033	24138-24142	MD	denotes	will
T15034	24152-24157	VB	denotes	knock
T15035	24162-24166	NNS	denotes	mice
T15036	24157-24158	HYPH	denotes	-
T15037	24158-24161	RP	denotes	out
T15038	24167-24169	TO	denotes	to
T15039	24170-24181	VB	denotes	investigate
T15040	24182-24185	DT	denotes	the
T15041	24186-24190	NN	denotes	role
T15042	24191-24193	IN	denotes	of
T15043	24194-24197	DT	denotes	the
T15044	24198-24203	NNS	denotes	genes
T15045	24204-24206	IN	denotes	in
T15046	24207-24210	NN	denotes	CIA
T15047	24210-24211	.	denotes	.
T15048	24211-24375	sentence	denotes	For the loci whose counterparts on the human genome are linked to RA, we will investigate the candidate genes using case-control association studies in RA cohorts.
T15049	24212-24215	IN	denotes	For
T15050	24290-24301	VB	denotes	investigate
T15051	24216-24219	DT	denotes	the
T15052	24220-24224	NNS	denotes	loci
T15053	24225-24230	WP$	denotes	whose
T15054	24231-24243	NNS	denotes	counterparts
T15055	24268-24274	VBN	denotes	linked
T15056	24244-24246	IN	denotes	on
T15057	24247-24250	DT	denotes	the
T15058	24257-24263	NN	denotes	genome
T15059	24251-24256	JJ	denotes	human
T15060	24264-24267	VBP	denotes	are
T15061	24275-24277	IN	denotes	to
T15062	24278-24280	NN	denotes	RA
T15063	24280-24282	,	denotes	,
T15064	24282-24284	PRP	denotes	we
T15065	24285-24289	MD	denotes	will
T15066	24302-24305	DT	denotes	the
T15067	24316-24321	NNS	denotes	genes
T15068	24306-24315	NN	denotes	candidate
T15069	24322-24327	VBG	denotes	using
T15070	24328-24332	NN	denotes	case
T15071	24333-24340	NN	denotes	control
T15072	24332-24333	HYPH	denotes	-
T15073	24353-24360	NNS	denotes	studies
T15074	24341-24352	NN	denotes	association
T15075	24361-24363	IN	denotes	in
T15076	24364-24366	NN	denotes	RA
T15077	24367-24374	NNS	denotes	cohorts
T15078	24374-24375	.	denotes	.
T14547	23182-23185	CC	denotes	and
T14548	23186-23189	DT	denotes	the
T14549	23194-23203	NN	denotes	threshold
T14550	23190-23193	JJ	denotes	low
T14551	23204-23208	VBN	denotes	used
T14552	23209-23211	TO	denotes	to
T14553	23212-23218	VB	denotes	detect
T14554	23219-23223	NN	denotes	gene
T14555	23224-23234	NN	denotes	expression
T14556	23235-23240	MD	denotes	could
T14557	23241-23245	RB	denotes	also
T14558	23253-23255	IN	denotes	in
T14559	23256-23261	JJ	denotes	false
T14560	23262-23271	NNS	denotes	positives
T14561	23272-23274	IN	denotes	in
T14562	23275-23278	DT	denotes	the
T14563	23304-23309	NNS	denotes	genes
T14564	23279-23293	RB	denotes	differentially
T14565	23294-23303	VBN	denotes	expressed
T14566	23309-23310	.	denotes	.
T14567	23310-23456	sentence	denotes	Furthermore, the differential expression of a gene could result not only from allele difference between two strains, but also from other factors.
T14568	23311-23322	RB	denotes	Furthermore
T14569	23368-23374	VB	denotes	result
T14570	23322-23324	,	denotes	,
T14571	23324-23327	DT	denotes	the
T14572	23341-23351	NN	denotes	expression
T14573	23328-23340	JJ	denotes	differential
T14574	23352-23354	IN	denotes	of
T14575	23355-23356	DT	denotes	a
T14576	23357-23361	NN	denotes	gene
T14577	23362-23367	MD	denotes	could
R213	T2426	T2424	pobj	diseases,to
R214	T2427	T2426	amod	complex,diseases
R223	T2436	T2434	dobj	effect,having
R224	T2437	T2436	amod	small,effect
R238	T2453	T2447	appos	disease,arthritis
R239	T2454	T2453	amod	common,disease
R240	T2455	T2453	nmod	complex,disease
R241	T2456	T2453	amod	multifactorial,disease
R242	T2457	T2453	amod	autoimmune,disease
R252	T2469	T2467	dobj	basis,detect
R253	T2470	T2469	amod	genetic,basis
R259	T2476	T2478	nummod	30,regions
R260	T2477	T2476	quantmod	than,30
R261	T2478	T2480	nsubj	regions,shown
R262	T2479	T2478	amod	genomic,regions
R263	T2480	T2462	conj	shown,carried
R264	T2481	T2480	aux	have,shown
R275	T2494	T2492	pobj	regions,of
R276	T2495	T2494	amod	genomic,regions
R280	T2499	T2491	dobj	value,reach
R281	T2500	T2501	npadvmod	genome,wide
R283	T2502	T2501	punct	-,wide
R284	T2503	T2499	amod	significant,value
R285	T2504	T2499	compound	threshold,value
R308	T2529	T2523	dobj	effect,have
R309	T2530	T2529	amod	small,effect
R314	T2536	T2538	nsubjpass	contributions,seen
R315	T2537	T2536	amod	genetic,contributions
R321	T2544	T2542	pobj	genes,from
R322	T2545	T2544	compound	susceptibility,genes
R331	T2554	T2552	pobj	DR4,including
R332	T2555	T2554	punct	-,DR4
R348	T2573	T2571	pobj	DR4,for
R349	T2574	T2573	punct	-,DR4
R352	T2577	T2573	relcl	associated,DR4
R353	T2578	T2577	auxpass	is,associated
R354	T2579	T2577	advmod	strongly,associated
R359	T2584	T2570	nsubj	genes,have
R360	T2585	T2584	det	the,genes
R361	T2586	T2584	amod	other,genes
R362	T2587	T2584	compound	susceptibility,genes
R364	T2589	T2570	dobj	effect,have
R365	T2590	T2589	det	a,effect
R366	T2591	T2589	amod	small,effect
R369	T2660	T2657	punct	", ",QTL
R370	T2594	T2592	pobj	disease,on
R371	T2661	T2657	appos	Cia2,QTL
R372	T2595	T2570	punct	.,have
R373	T2662	T2659	punct	", ",identified
R374	T2663	T2659	auxpass	was,identified
R375	T2597	T2598	prep	In,observed
R376	T2664	T2659	prep	for,identified
R377	T2665	T2666	det	the,phenotype
R378	T2666	T2664	pobj	phenotype,for
R379	T2599	T2600	det	the,model
R380	T2667	T2666	prep	of,phenotype
R381	T2668	T2669	compound	CIA,severity
R382	T2669	T2667	pobj	severity,of
R383	T2670	T2659	punct	", ",identified
R384	T2600	T2597	pobj	model,In
R385	T2671	T2659	cc	but,identified
R386	T2672	T2673	det	this,QTL
R387	T2673	T2674	nsubj	QTL,contributes
R388	T2674	T2659	conj	contributes,identified
R389	T2601	T2600	compound	mouse,model
R390	T2675	T2674	prep	to,contributes
R391	T2676	T2677	advmod	only,16
R392	T2602	T2600	prep	of,model
R393	T2677	T2678	nummod	16,%
R394	T2678	T2675	pobj	%,to
R395	T2679	T2678	prep	of,%
R396	T2603	T2602	pobj	RA,of
R397	T2680	T2681	det	the,variations
R398	T2681	T2679	pobj	variations,of
R399	T2682	T2681	compound	phenotype,variations
R400	T2604	T2598	punct	", ",observed
R401	T2683	T2681	prep	for,variations
R402	T2684	T2685	compound	CIA,susceptibility
R403	T2685	T2683	pobj	susceptibility,for
R404	T2605	T2606	amod	small,contributions
R405	T2686	T2674	prep	in,contributes
R406	T2687	T2688	compound	F2,progeny
R407	T2606	T2598	nsubjpass	contributions,observed
R408	T2688	T2686	pobj	progeny,in
R409	T2607	T2606	amod	genetic,contributions
R410	T2608	T2598	auxpass	are,observed
R411	T2689	T2690	punct	[,10
R412	T2609	T2610	advmod	also,often
R413	T2690	T2674	parataxis	10,contributes
R414	T2691	T2690	punct	],10
R415	T2692	T2674	punct	.,contributes
R416	T2610	T2598	advmod	often,observed
R417	T2694	T2695	nsubj	This,suggests
R418	T2696	T2697	mark	that,be
R419	T2697	T2695	ccomp	be,suggests
R420	T2698	T2697	expl	there,be
R421	T2611	T2598	punct	.,observed
R422	T2699	T2697	aux	must,be
R423	T2700	T2701	amod	other,genes
R424	T2613	T2614	prep	For,carried
R425	T2701	T2697	attr	genes,be
R426	T2702	T2701	compound	susceptibility,genes
R427	T2703	T2704	poss	whose,contributions
R428	T2704	T2705	dep	contributions,were
R429	T2705	T2701	relcl	were,genes
R430	T2615	T2613	pobj	example,For
R431	T2706	T2705	neg	not,were
R432	T2707	T2705	acomp	big,were
R433	T2708	T2707	advmod	enough,big
R434	T2616	T2614	punct	", ",carried
R435	T2709	T2710	aux	to,reach
R436	T2710	T2707	xcomp	reach,big
R437	T2711	T2712	det	the,value
R438	T2617	T2614	prep	in,carried
R439	T2712	T2710	dobj	value,reach
R440	T2713	T2712	amod	stringent,value
R441	T2714	T2712	compound	significance,value
R442	T2715	T2712	compound	threshold,value
R443	T2618	T2619	det	a,study
R444	T2716	T2712	prep	of,value
R445	T2717	T2718	compound	linkage,analysis
R446	T2619	T2617	pobj	study,in
R447	T2718	T2716	pobj	analysis,of
R448	T2719	T2695	punct	.,suggests
R449	T2620	T2619	amod	previous,study
R450	T2721	T2722	nummod	One,aim
R451	T2722	T2723	nsubj	aim,is
R452	T2621	T2614	punct	", ",carried
R453	T2724	T2722	prep	of,aim
R454	T2725	T2724	pcomp	using,of
R455	T2622	T2614	nsubj	we,carried
R456	T2726	T2727	compound	animal,models
R457	T2727	T2725	dobj	models,using
R458	T2728	T2725	prep	for,using
R459	T2623	T2614	prt	out,carried
R460	T2729	T2730	amod	complex,diseases
R461	T2730	T2728	pobj	diseases,for
R462	T2624	T2625	det	a,screen
R463	T2731	T2732	aux	to,detect
R464	T2732	T2723	xcomp	detect,is
R465	T2625	T2614	dobj	screen,carried
R466	T2733	T2734	det	the,basis
R467	T2734	T2732	dobj	basis,detect
R468	T2735	T2734	amod	genetic,basis
R469	T2736	T2734	prep	of,basis
R470	T2737	T2738	det	these,diseases
R471	T2738	T2736	pobj	diseases,of
R472	T2739	T2723	punct	.,is
R473	T2626	T2625	compound	genome,screen
R474	T2741	T2742	prep	With,are
R475	T2627	T2628	aux	to,identify
R476	T2743	T2744	amod	controllable,factors
R477	T2744	T2741	pobj	factors,With
R478	T2628	T2614	advcl	identify,carried
R479	T2745	T2744	amod	environmental,factors
R480	T2746	T2747	advmod	as,as
R481	T2747	T2744	cc	as,factors
R482	T2629	T2630	det	the,loci
R483	T2748	T2747	advmod	well,as
R484	T2749	T2750	det	the,background
R485	T2750	T2744	conj	background,factors
R486	T2630	T2628	dobj	loci,identify
R487	T2751	T2750	amod	known,background
R488	T2752	T2750	amod	genetic,background
R489	T2753	T2742	punct	", ",are
R490	T2631	T2632	amod	quantitative,trait
R491	T2754	T2755	compound	animal,models
R492	T2755	T2742	nsubj	models,are
R493	T2756	T2757	amod	powerful,tools
R494	T2632	T2630	compound	trait,loci
R495	T2633	T2630	punct	(,loci
R496	T2757	T2742	attr	tools,are
R497	T2634	T2630	appos	QTL,loci
R498	T2758	T2759	aux	to,search
R499	T2759	T2757	advcl	search,tools
R500	T2635	T2628	punct	),identify
R501	T2760	T2759	prep	for,search
R502	T2761	T2762	compound	susceptibility,genes
R503	T2762	T2760	pobj	genes,for
R504	T2636	T2628	prep	in,identify
R505	T2763	T2762	prep	for,genes
R506	T2764	T2765	amod	complex,diseases
R507	T2765	T2763	pobj	diseases,for
R508	T2637	T2638	npadvmod	collagen,induced
R509	T2638	T2640	amod	induced,arthritis
R510	T2639	T2638	punct	-,induced
R511	T2640	T2636	pobj	arthritis,in
R512	T2766	T2742	punct	", ",are
R513	T2767	T2742	cc	and,are
R514	T2768	T2769	aux	have,employed
R515	T2641	T2640	punct	(,arthritis
R516	T2769	T2742	conj	employed,are
R517	T2770	T2769	auxpass	been,employed
R518	T2642	T2640	appos	CIA,arthritis
R519	T2771	T2769	advmod	intensively,employed
R520	T2772	T2769	prep	for,employed
R521	T2773	T2774	det	that,purpose
R522	T2774	T2772	pobj	purpose,for
R523	T2775	T2742	punct	.,are
R524	T2643	T2640	punct	),arthritis
R525	T2644	T2640	punct	", ",arthritis
R526	T2777	T2778	amod	More,"27,000"
R527	T2778	T2780	nummod	"27,000",QTL
R528	T2779	T2778	quantmod	than,"27,000"
R529	T2645	T2646	dep	which,is
R530	T2780	T2781	nsubjpass	QTL,identified
R531	T2646	T2640	relcl	is,arthritis
R532	T2782	T2781	aux	have,identified
R533	T2783	T2781	auxpass	been,identified
R534	T2784	T2781	prep	in,identified
R535	T2647	T2648	det	a,model
R536	T2785	T2786	det	the,genome
R537	T2786	T2784	pobj	genome,in
R538	T2648	T2646	attr	model,is
R539	T2787	T2786	compound	mouse,genome
R540	T2788	T2789	mark	since,identified
R541	T2789	T2781	advcl	identified,identified
R542	T2649	T2650	advmod	widely,used
R543	T2790	T2791	det	the,QTL
R544	T2791	T2789	nsubjpass	QTL,identified
R545	T2792	T2791	amod	first,QTL
R546	T2650	T2648	amod	used,model
R547	T2793	T2789	auxpass	was,identified
R548	T2794	T2789	prep	at,identified
R549	T2651	T2648	compound	animal,model
R550	T2795	T2796	det	the,beginning
R551	T2796	T2794	pobj	beginning,at
R552	T2797	T2796	prep	of,beginning
R553	T2798	T2799	det	the,1990s
R554	T2652	T2648	prep	of,model
R555	T2799	T2797	pobj	1990s,of
R556	T2800	T2801	punct	[,11
R557	T2653	T2652	pobj	RA,of
R558	T2801	T2781	parataxis	11,identified
R559	T2802	T2801	punct	],11
R560	T2803	T2781	punct	.,identified
R561	T2654	T2614	punct	.,carried
R562	T2805	T2806	prep	By,identified
R563	T2656	T2657	advmod	Only,QTL
R564	T2807	T2805	pobj	2005,By
R565	T2808	T2806	punct	", ",identified
R566	T2809	T2810	advmod	approximately,20
R567	T2810	T2811	nummod	20,genes
R568	T2657	T2659	nsubjpass	QTL,identified
R569	T2811	T2806	nsubjpass	genes,identified
R572	T2658	T2657	nummod	one,QTL
R578	T2819	T2817	pobj	genome,in
R579	T2872	T2873	amod	small,effect
R580	T2820	T2819	compound	mouse,genome
R581	T2821	T2806	aux	had,identified
R582	T2822	T2806	auxpass	been,identified
R583	T2823	T2824	punct	[,13
R584	T2824	T2806	parataxis	13,identified
R585	T2825	T2824	nummod	12,13
R586	T2873	T2875	compound	effect,QTL
R587	T2826	T2824	punct	",",13
R588	T2827	T2824	punct	],13
R589	T2828	T2806	punct	.,identified
R590	T2874	T2873	punct	-,effect
R591	T2830	T2831	advmod	Interestingly,have
R592	T2875	T2866	nsubj	QTL,are
R593	T2832	T2831	punct	", ",have
R594	T2833	T2834	amod	most,QTGs
R595	T2876	T2866	acomp	difficult,are
R596	T2834	T2831	nsubj	QTGs,have
R597	T2835	T2834	acl	identified,QTGs
R598	T2877	T2878	aux	to,identify
R599	T2836	T2835	prep	in,identified
R600	T2837	T2838	compound	animal,models
R601	T2838	T2836	pobj	models,in
R602	T2878	T2876	advcl	identify,difficult
R603	T2839	T2840	det	the,polymorphisms
R604	T2840	T2831	dobj	polymorphisms,have
R605	T2879	T2878	prep	with,identify
R606	T2841	T2840	amod	causal,polymorphisms
R607	T2842	T2840	prep	in,polymorphisms
R608	T2843	T2844	det	the,region
R609	T2880	T2881	amod	traditional,strategies
R610	T2844	T2842	pobj	region,in
R611	T2845	T2846	npadvmod	protein,coding
R612	T2846	T2844	amod	coding,region
R613	T2881	T2879	pobj	strategies,with
R614	T2847	T2846	punct	-,coding
R615	T2848	T2849	punct	[,14
R616	T2849	T2844	parataxis	14,region
R617	T2882	T2866	cc	and,are
R618	T2850	T2849	punct	],14
R619	T2851	T2840	punct	", ",polymorphisms
R620	T2852	T2853	dep	which,provoke
R621	T2883	T2866	punct	", ",are
R622	T2853	T2840	relcl	provoke,polymorphisms
R623	T2854	T2855	compound	protein,changes
R624	T2884	T2885	prep	on,affect
R625	T2855	T2853	dobj	changes,provoke
R626	T2856	T2855	compound	structure,changes
R627	T2857	T2855	cc	or,changes
R628	T2858	T2859	compound	protein,deficiency
R629	T2859	T2855	conj	deficiency,changes
R630	T2860	T2831	punct	.,have
R631	T2885	T2866	conj	affect,are
R632	T2862	T2863	nsubj	This,suggests
R633	T2886	T2887	det	the,hand
R634	T2864	T2863	punct	", ",suggests
R635	T2887	T2884	pobj	hand,on
R636	T2865	T2866	prep	on,are
R637	T2888	T2887	amod	other,hand
R638	T2866	T2863	advcl	are,suggests
R639	T2867	T2868	det	the,hand
R640	T2889	T2885	punct	", ",affect
R641	T2868	T2865	pobj	hand,on
R642	T2869	T2868	nummod	one,hand
R643	T2870	T2866	punct	", ",are
R645	T2871	T2866	mark	that,are
R646	T2891	T2892	det	the,polymorphisms
R647	T2892	T2885	nsubj	polymorphisms,affect
R648	T2893	T2892	acl	regulating,polymorphisms
R649	T2894	T2895	compound	gene,expression
R650	T2978	T2977	amod	past,decade
R651	T2979	T2975	punct	", ",applied
R652	T2895	T2893	dobj	expression,regulating
R653	T2980	T2981	amod	many,studies
R654	T2981	T2975	nsubj	studies,applied
R655	T2896	T2885	aux	might,affect
R656	T2982	T2983	det	this,technique
R657	T2983	T2975	dobj	technique,applied
R658	T2897	T2898	advmod	only,slightly
R659	T2984	T2985	aux	to,study
R660	T2985	T2975	advcl	study,applied
R661	T2986	T2987	preconj	both,RA
R662	T2987	T2985	dobj	RA,study
R663	T2898	T2885	advmod	slightly,affect
R664	T2988	T2987	cc	and,RA
R665	T2989	T2990	poss	its,models
R666	T2899	T2900	det	the,traits
R667	T2990	T2987	conj	models,RA
R668	T2991	T2990	compound	animal,models
R669	T2992	T2993	punct	[,15
R670	T2900	T2885	dobj	traits,affect
R671	T2993	T2975	parataxis	15,applied
R672	T2994	T2995	punct	-,22
R673	T2995	T2993	prep	22,15
R674	T2901	T2900	amod	quantitative,traits
R675	T2996	T2993	punct	],15
R676	T2997	T2975	punct	.,applied
R677	T2902	T2885	punct	", ",affect
R678	T2999	T3000	advmod	Indeed,show
R679	T3001	T3000	punct	", ",show
R680	T3002	T3000	nsubj	genes,show
R681	T3003	T3002	acl	involved,genes
R682	T2903	T2885	cc	and,affect
R683	T3004	T3003	prep	in,involved
R684	T3005	T3004	pobj	arthritis,in
R685	T3006	T3007	amod	distinct,patterns
R686	T3007	T3000	dobj	patterns,show
R687	T2904	T2905	advmod	thus,are
R688	T3008	T3007	compound	expression,patterns
R689	T3009	T3007	prep	in,patterns
R690	T3010	T3011	amod	certain,tissues
R691	T2905	T2885	conj	are,affect
R692	T3011	T3009	pobj	tissues,in
R693	T3012	T3011	cc	and,tissues
R694	T3013	T3014	amod	pathological,stages
R695	T2906	T2907	advmod	more,difficult
R696	T3014	T3011	conj	stages,tissues
R697	T3015	T3014	prep	of,stages
R698	T3016	T3017	det	the,disease
R699	T2907	T2905	acomp	difficult,are
R700	T3017	T3015	pobj	disease,of
R701	T3018	T3000	punct	.,show
R702	T2908	T2909	aux	to,identify
R703	T3020	T3021	nsubjpass	Genes,expressed
R704	T2909	T2907	advcl	identify,difficult
R705	T3022	T3020	acl	involved,Genes
R706	T3023	T3022	prep	in,involved
R707	T3024	T3025	amod	immunoinflammatory,responses
R708	T3025	T3023	pobj	responses,in
R709	T2910	T2863	punct	.,suggests
R710	T3026	T3021	auxpass	were,expressed
R711	T3027	T3021	advmod	differentially,expressed
R712	T3028	T3021	prep	in,expressed
R713	T2912	T2913	npadvmod	Microarray,based
R714	T3029	T3030	det	the,cells
R715	T3030	T3028	pobj	cells,in
R716	T3031	T3030	compound	blood,cells
R717	T3032	T3021	prep	in,expressed
R718	T2913	T2915	amod	based,expression
R719	T3033	T3034	compound	RA,patients
R720	T3034	T3032	pobj	patients,in
R721	T3035	T3036	punct	[,18
R722	T2914	T2913	punct	-,based
R723	T3036	T3021	parataxis	18,expressed
R724	T3037	T3036	punct	],18
R725	T3038	T3021	punct	.,expressed
R726	T2915	T2918	nsubj	expression,is
R727	T2916	T2915	amod	global,expression
R728	T2917	T2915	compound	gene,expression
R729	T3040	T3041	nsubjpass	Chemokines,upregulated
R730	T2919	T2920	det	a,technique
R731	T3042	T3040	cc	and,Chemokines
R732	T3043	T3044	compound	adhesion,molecules
R733	T3044	T3040	conj	molecules,Chemokines
R734	T3045	T3041	auxpass	were,upregulated
R735	T3046	T3041	prep	in,upregulated
R736	T3047	T3048	det	the,joint
R737	T3048	T3046	pobj	joint,in
R738	T2920	T2918	attr	technique,is
R739	T3049	T3041	prep	at,upregulated
R740	T3050	T3051	det	the,phase
R741	T3051	T3049	pobj	phase,at
R742	T2921	T2920	amod	powerful,technique
R743	T3052	T3051	compound	initiation,phase
R744	T2922	T2920	prep	for,technique
R745	T3053	T3051	prep	of,phase
R746	T3054	T3053	pobj	arthritis,of
R747	T3055	T3041	prep	in,upregulated
R748	T3056	T3057	compound	animal,models
R749	T2923	T2922	pcomp	investigating,for
R750	T3057	T3055	pobj	models,in
R751	T3058	T3059	punct	[,22
R752	T3059	T3041	parataxis	22,upregulated
R753	T2924	T2925	amod	complex,diseases
R754	T3060	T3059	nummod	21,22
R755	T3061	T3059	punct	",",22
R756	T3062	T3059	punct	],22
R757	T2925	T2923	dobj	diseases,investigating
R758	T3063	T3041	punct	", ",upregulated
R759	T3064	T3065	mark	while,expressed
R760	T2926	T2918	punct	.,is
R761	T3065	T3041	advcl	expressed,upregulated
R762	T3066	T3065	nsubjpass	genes,expressed
R763	T3067	T3066	acl	involved,genes
R764	T3068	T3067	prep	in,involved
R765	T2928	T2929	prep	During,are
R766	T3069	T3070	compound	cartilage,destruction
R767	T3070	T3068	pobj	destruction,in
R768	T3071	T3070	cc	and,destruction
R769	T3072	T3073	compound	bone,erosion
R770	T2930	T2931	compound	disease,development
R771	T3073	T3070	conj	erosion,destruction
R772	T3074	T3065	auxpass	were,expressed
R773	T3075	T3065	advmod	differentially,expressed
R774	T3076	T3065	prep	at,expressed
R775	T2931	T2928	pobj	development,During
R776	T3077	T3078	det	the,phase
R777	T3078	T3076	pobj	phase,at
R778	T3079	T3078	amod	late,phase
R779	T2932	T2929	punct	", ",are
R780	T3080	T3078	prep	of,phase
R781	T3081	T3080	pobj	arthritis,of
R782	T3082	T3065	prep	in,expressed
R783	T2933	T2929	nsubj	genes,are
R784	T3083	T3084	compound	animal,models
R785	T2934	T2933	acl	involved,genes
R786	T2935	T2934	prep	in,involved
R787	T3084	T3082	pobj	models,in
R788	T2936	T2937	det	the,disease
R789	T3085	T3084	prep	of,models
R790	T3086	T3085	pobj	RA,of
R791	T3087	T3088	punct	[,16
R792	T2937	T2935	pobj	disease,in
R793	T3088	T3065	parataxis	16,expressed
R794	T3089	T3088	nummod	15,16
R795	T2938	T2929	acomp	likely,are
R796	T3090	T3088	punct	",",16
R797	T2939	T2940	aux	to,regulated
R798	T3091	T3088	punct	],16
R799	T3092	T3041	punct	.,upregulated
R800	T3094	T3095	mark	Besides,detecting
R801	T2940	T2938	xcomp	regulated,likely
R802	T3095	T3096	advcl	detecting,used
R803	T2941	T2940	auxpass	be,regulated
R804	T3097	T3095	dobj	genes,detecting
R805	T3098	T3097	acl	involved,genes
R806	T3099	T3098	prep	in,involved
R807	T2942	T2940	advmod	differentially,regulated
R808	T3100	T3101	amod	complex,diseases
R809	T3101	T3099	pobj	diseases,in
R810	T3102	T3096	punct	", ",used
R811	T3103	T3096	nsubjpass	microarrays,used
R812	T2943	T2929	punct	.,are
R813	T3104	T3096	aux	could,used
R814	T3105	T3096	advmod	also,used
R815	T3106	T3096	auxpass	be,used
R816	T2945	T2946	advmod	Therefore,identified
R817	T3107	T3108	aux	to,detect
R818	T3108	T3096	advcl	detect,used
R819	T3109	T3110	det	the,polymorphisms
R820	T3110	T3108	dobj	polymorphisms,detect
R821	T2947	T2946	punct	", ",identified
R822	T3111	T3110	amod	genetic,polymorphisms
R823	T3112	T3110	acl	regulating,polymorphisms
R824	T3113	T3114	compound	gene,expression
R825	T3114	T3112	dobj	expression,regulating
R826	T3115	T3116	mark	because,be
R827	T2948	T2949	compound	signature,genes
R828	T3116	T3108	advcl	be,detect
R829	T3117	T3118	amod	differential,expressions
R830	T2949	T2946	nsubjpass	genes,identified
R831	T3118	T3116	nsubj	expressions,be
R832	T3119	T3118	prep	between,expressions
R833	T3120	T3121	nummod	two,strains
R834	T2950	T2949	prep	of,genes
R835	T3121	T3119	pobj	strains,between
R836	T3122	T3116	aux	might,be
R837	T3123	T3124	det	the,result
R838	T3124	T3116	attr	result,be
R839	T2951	T2952	det	the,diseases
R840	T3125	T3124	prep	of,result
R841	T3126	T3127	det	a,polymorphism
R842	T3127	T3125	pobj	polymorphism,of
R843	T2952	T2950	pobj	diseases,of
R844	T3128	T3127	acl	located,polymorphism
R845	T3129	T3128	prep	in,located
R846	T3130	T3131	amod	regulatory,elements
R847	T2953	T2946	aux	could,identified
R848	T3131	T3129	pobj	elements,in
R849	T3132	T3096	punct	.,used
R850	T2954	T2946	auxpass	be,identified
R851	T3134	T3135	aux	To,identify
R852	T3135	T3136	advcl	identify,investigated
R853	T2955	T2946	prep	by,identified
R854	T3137	T3138	det	the,QTL
R855	T3138	T3135	dobj	QTL,identify
R856	T2956	T2955	pcomp	detecting,by
R857	T3139	T3140	amod	small,effect
R858	T3140	T3138	compound	effect,QTL
R859	T3141	T3140	punct	-,effect
R860	T3142	T3138	prep	of,QTL
R861	T2957	T2958	det	the,patterns
R862	T3143	T3142	pobj	CIA,of
R863	T3144	T3145	advmod	as,as
R864	T3145	T3138	cc	as,QTL
R865	T2958	T2956	dobj	patterns,detecting
R866	T3146	T3145	advmod	well,as
R867	T3147	T3148	det	the,genes
R868	T3148	T3138	conj	genes,QTL
R869	T2959	T2958	compound	expression,patterns
R870	T2960	T2958	prep	of,patterns
R871	T3149	T3148	amod	potential,genes
R872	T2961	T2962	det	the,tissues
R873	T3150	T3148	compound	candidate,genes
R874	T3151	T3148	prep	inside,genes
R875	T3152	T3151	pobj	them,inside
R876	T2962	T2960	pobj	tissues,of
R877	T3153	T3136	punct	", ",investigated
R878	T3154	T3136	nsubj	we,investigated
R879	T2963	T2964	npadvmod	disease,related
R880	T3155	T3156	npadvmod	CIA,susceptible
R881	T3156	T3158	amod	susceptible,strains
R882	T3157	T3156	advmod	genetically,susceptible
R883	T2964	T2962	amod	related,tissues
R884	T3158	T3136	dobj	strains,investigated
R885	T3159	T3156	cc	and,susceptible
R886	T3160	T3156	conj	resistant,susceptible
R887	T2965	T2964	punct	-,related
R888	T3161	T3136	prep	at,investigated
R889	T3162	T3163	preconj	both,genome
R890	T3163	T3165	nmod	genome,levels
R891	T3164	T3163	det	the,genome
R892	T3165	T3161	pobj	levels,at
R893	T3166	T3163	cc	and,genome
R894	T3167	T3163	conj	transcriptome,genome
R895	T2966	T2962	compound	cells,tissues
R896	T3168	T3136	punct	.,investigated
R897	T3170	T3171	prep	At,generated
R898	T2967	T2962	punct	/,tissues
R899	T3172	T3173	det	the,level
R900	T3173	T3170	pobj	level,At
R901	T2968	T2962	cc	and,tissues
R902	T3174	T3173	compound	genome,level
R903	T2969	T2970	poss	their,controls
R904	T3175	T3171	punct	", ",generated
R905	T3176	T3177	compound	F2,progeny
R906	T3177	T3171	nsubjpass	progeny,generated
R907	T3178	T3177	prep	of,progeny
R908	T2970	T2962	conj	controls,tissues
R909	T3179	T3180	det	the,strains
R910	T3180	T3178	pobj	strains,of
R911	T3181	T3180	amod	CIA,strains
R912	T2971	T2970	amod	ideal,controls
R913	T3182	T3181	amod	susceptible,CIA
R914	T3183	T3184	punct	(,DBA
R915	T3184	T3182	parataxis	DBA,susceptible
R916	T2972	T2946	punct	.,identified
R917	T3185	T3184	punct	/,DBA
R918	T3186	T3184	nummod	1,DBA
R919	T3187	T3184	punct	),DBA
R920	T2974	T2975	prep	In,applied
R921	T3188	T3181	cc	and,CIA
R922	T3189	T3181	conj	resistant,CIA
R923	T2976	T2977	det	the,decade
R924	T2977	T2974	pobj	decade,In
R925	T3190	T3191	punct	(,N
R926	T3191	T3189	parataxis	N,resistant
R927	T3192	T3191	compound	FVB,N
R928	T3193	T3191	punct	/,N
R929	T3194	T3191	punct	),N
R933	T3198	T3203	nsubjpass	analysis,performed
R934	T3199	T3200	npadvmod	genome,wide
R936	T3201	T3200	punct	-,wide
R937	T3202	T3198	compound	linkage,analysis
R938	T3203	T3171	conj	performed,generated
R939	T3204	T3203	auxpass	was,performed
R943	T3208	T3210	compound	effect,QTL
R944	T3209	T3208	punct	-,effect
R949	T3216	T3213	pobj	level,At
R950	T3217	T3216	compound	transcriptome,level
R954	T3221	T3214	dobj	patterns,detected
R955	T3222	T3223	compound	gene,expression
R956	T3223	T3221	compound	expression,patterns
R959	T3226	T3224	pobj	strains,of
R960	T3227	T3226	det	the,strains
R961	T3228	T3226	nmod	DBA,strains
R962	T3229	T3228	punct	/,DBA
R963	T3230	T3228	nummod	1,DBA
R964	T3231	T3228	cc	and,DBA
R965	T3232	T3233	compound	FVB,N
R967	T3234	T3233	punct	/,N
R970	T3237	T3235	pobj	phases,at
R971	T3238	T3237	amod	different,phases
R976	T3244	T3247	nsubjpass	genes,identified
R977	T3245	T3244	amod	potential,genes
R978	T3246	T3244	compound	candidate,genes
R979	T3247	T3249	ccomp	identified,located
R980	T3248	T3247	auxpass	were,identified
R990	T3259	T3257	pobj	region,within
R991	T3260	T3259	amod	genomic,region
R997	T3266	T3249	conj	expressed,located
R998	T3267	T3266	auxpass	are,expressed
R999	T3268	T3269	npadvmod	disease,specific
R1001	T3270	T3269	punct	-,specific
R1002	T3271	T3266	advmod	differentially,expressed
R1008	T3277	T3266	conj	expressed,expressed
R1009	T3278	T3277	auxpass	are,expressed
R1010	T3279	T3280	npadvmod	strain,specific
R1012	T3281	T3280	punct	-,specific
R1013	T3282	T3277	advmod	differentially,expressed
R1016	T3285	T3283	pobj	strains,between
R1017	T3286	T3285	nummod	two,strains
R1018	T3287	T3285	amod	parental,strains
R1022	T4045	T4044	punct	", ",Animals
R1023	T4046	T4044	conj	immunisation,Animals
R1024	T4047	T4046	cc	and,immunisation
R1025	T4048	T4046	conj	assessment,immunisation
R1026	T4049	T4048	prep	of,assessment
R1027	T4050	T4049	pobj	arthritis,of
R1028	T4052	T4053	preconj	Both,DBA
R1029	T4053	T4054	nmod	DBA,mice
R1030	T4054	T4061	nsubjpass	mice,obtained
R1031	T4055	T4053	punct	/,DBA
R1032	T4056	T4053	nummod	1,DBA
R1033	T4057	T4053	cc	and,DBA
R1034	T4058	T4059	compound	FVB,N
R1035	T4059	T4053	conj	N,DBA
R1037	T4062	T4054	acl	used,mice
R1038	T4063	T4062	prep	in,used
R1039	T4064	T4065	det	this,study
R1040	T4065	T4063	pobj	study,in
R1041	T4066	T4061	auxpass	were,obtained
R1042	T4067	T4061	prep	from,obtained
R1043	T4068	T4069	det	the,Laboratory
R1044	T4069	T4067	pobj	Laboratory,from
R1045	T4070	T4069	compound	Jackson,Laboratory
R1046	T4071	T4061	cc	and,obtained
R1047	T4072	T4061	conj	kept,obtained
R1048	T4073	T4072	prep	in,kept
R1049	T4074	T4075	det	a,environment
R1050	T4075	T4073	pobj	environment,in
R1051	T4076	T4077	npadvmod	climate,controlled
R1052	T4077	T4075	amod	controlled,environment
R1054	T4079	T4075	prep	with,environment
R1055	T4080	T4081	nummod	12,hour
R1056	T4081	T4082	compound	hour,cycles
R1057	T4082	T4079	pobj	cycles,with
R1058	T4083	T4084	compound	light,dark
R1059	T4084	T4082	compound	dark,cycles
R1061	T4086	T4075	prep	in,environment
R1062	T4087	T4088	det	the,facility
R1063	T4088	T4086	pobj	facility,in
R1064	T4089	T4088	compound	animal,facility
R1065	T4090	T4088	prep	at,facility
R1066	T4091	T4092	det	the,University
R1067	T4092	T4090	pobj	University,at
R1068	T4093	T4092	prep	of,University
R1069	T4094	T4093	pobj	Rostock,of
R1070	T4095	T4061	punct	.,obtained
R1071	T4097	T4098	det	All,experiments
R1072	T4098	T4100	nsubjpass	experiments,pre-approved
R1073	T4099	T4098	compound	animal,experiments
R1074	T4101	T4100	auxpass	were,pre-approved
R1075	T4102	T4100	agent	by,pre-approved
R1076	T4103	T4104	det	the,Committee
R1077	T4104	T4102	pobj	Committee,by
R1078	T4105	T4104	compound	State,Committee
R1079	T4106	T4107	compound	Animal,Care
R1080	T4107	T4104	compound	Care,Committee
R1081	T4108	T4100	punct	.,pre-approved
R1082	T4110	T4111	nsubjpass	CIA,induced
R1083	T4112	T4111	auxpass	was,induced
R1084	T4113	T4111	prep	in,induced
R1085	T4114	T4115	nmod	control,animals
R1086	T4115	T4113	pobj	animals,in
R1087	T4116	T4114	cc	and,control
R1088	T4117	T4114	conj	experimental,control
R1089	T4118	T4111	prep	according,induced
R1090	T4119	T4118	prep	to,according
R1091	T4120	T4121	amod	established,protocols
R1092	T4121	T4119	pobj	protocols,to
R1093	T4122	T4121	acl	described,protocols
R1094	T4123	T4122	advmod	previously,described
R1095	T4124	T4125	punct	[,10
R1096	T4125	T4111	parataxis	10,induced
R1097	T4126	T4125	punct	],10
R1098	T4127	T4111	punct	.,induced
R1099	T4129	T4130	prep	In,immunised
R1100	T4131	T4129	pobj	brief,In
R1101	T4132	T4130	punct	", ",immunised
R1102	T4133	T4134	nmod	DBA,1J
R1103	T4134	T4136	nmod	1J,progeny
R1104	T4135	T4134	punct	/,1J
R1105	T4136	T4130	nsubjpass	progeny,immunised
R1106	T4137	T4134	punct	", ",1J
R1107	T4138	T4139	compound	FVB,N
R1108	T4139	T4134	conj	N,1J
R1110	T4141	T4139	cc	and,N
R1111	T4142	T4143	punct	(,1J
R1112	T4143	T4139	conj	1J,N
R1115	T4146	T4143	punct	×,1J
R1116	T4147	T4148	compound	FVB,N
R1117	T4148	T4143	appos	N,1J
R1119	T4150	T4143	punct	),1J
R1120	T4151	T4136	compound	F2,progeny
R1121	T4152	T4130	auxpass	were,immunised
R1122	T4153	T4130	prep	at,immunised
R1123	T4154	T4155	quantmod	8,12
R1124	T4155	T4157	nummod	12,weeks
R1125	T4156	T4155	quantmod	to,12
R1126	T4157	T4153	pobj	weeks,at
R1127	T4158	T4130	prep	at,immunised
R1128	T4159	T4160	det	the,base
R1129	T4160	T4158	pobj	base,at
R1130	T4161	T4160	prep	of,base
R1131	T4162	T4163	det	the,tail
R1132	T4163	T4161	pobj	tail,of
R1133	T4164	T4130	prep	with,immunised
R1134	T4165	T4166	nummod	125,μg
R1135	T4166	T4164	pobj	μg,with
R1136	T4167	T4166	prep	of,μg
R1137	T4168	T4169	amod	bovine,Collagen
R1138	T4169	T4167	pobj	Collagen,of
R1139	T4170	T4169	nummod	II,Collagen
R1140	T4171	T4172	punct	(,Chondrex
R1141	T4172	T4169	parataxis	Chondrex,Collagen
R1142	T4173	T4172	punct	", ",Chondrex
R1143	T4174	T4172	npadvmod	Redmond,Chondrex
R1144	T4175	T4172	punct	", ",Chondrex
R1145	T4176	T4172	npadvmod	WA,Chondrex
R1146	T4177	T4172	punct	", ",Chondrex
R1147	T4178	T4172	npadvmod	USA,Chondrex
R1148	T4179	T4172	punct	),Chondrex
R1149	T4180	T4169	acl	emulsified,Collagen
R1150	T4181	T4180	prep	in,emulsified
R1151	T4182	T4181	pobj	CFA,in
R1152	T4183	T4184	punct	(,DIFCO
R1153	T4184	T4182	parataxis	DIFCO,CFA
R1154	T4185	T4184	punct	", ",DIFCO
R1155	T4186	T4184	npadvmod	Detroit,DIFCO
R1156	T4187	T4184	punct	", ",DIFCO
R1157	T4188	T4184	npadvmod	MI,DIFCO
R1158	T4189	T4184	punct	", ",DIFCO
R1159	T4190	T4184	npadvmod	USA,DIFCO
R1160	T4191	T4184	punct	),DIFCO
R1161	T4192	T4130	punct	.,immunised
R1162	T4194	T4195	det	The,scoring
R1163	T4195	T4197	nsubj	scoring,commenced
R1164	T4196	T4195	amod	clinical,scoring
R1165	T4198	T4195	prep	of,scoring
R1166	T4199	T4198	pobj	arthritis,of
R1167	T4200	T4201	nummod	18,days
R1168	T4201	T4202	npadvmod	days,after
R1169	T4202	T4197	prep	after,commenced
R1170	T4203	T4202	pobj	immunisation,after
R1171	T4204	T4197	punct	", ",commenced
R1172	T4205	T4197	cc	and,commenced
R1173	T4206	T4207	nsubjpass	animals,monitored
R1174	T4207	T4197	conj	monitored,commenced
R1175	T4208	T4207	auxpass	were,monitored
R1176	T4209	T4210	nummod	three,times
R1177	T4210	T4211	npadvmod	times,weekly
R1178	T4211	T4207	advmod	weekly,monitored
R1179	T4212	T4207	prep	for,monitored
R1180	T4213	T4212	pobj	signs,for
R1181	T4214	T4213	prep	of,signs
R1182	T4215	T4214	pobj	CIA,of
R1183	T4216	T4207	punct	.,monitored
R1184	T4218	T4219	compound	Arthritis,development
R1185	T4219	T4220	nsubjpass	development,monitored
R1186	T4221	T4220	auxpass	was,monitored
R1187	T4222	T4220	prep	in,monitored
R1188	T4223	T4224	det	all,limbs
R1189	T4224	T4222	pobj	limbs,in
R1190	T4225	T4224	nummod	four,limbs
R1191	T4226	T4220	advcl	using,monitored
R1192	T4227	T4228	det	a,system
R1193	T4228	T4226	dobj	system,using
R1194	T4229	T4230	nummod	three,score
R1195	T4230	T4228	compound	score,system
R1197	T4232	T4228	prep	per,system
R1198	T4233	T4232	pobj	limb,per
R1199	T4234	T4235	mark	as,described
R1200	T4235	T4226	advcl	described,using
R1201	T4236	T4235	advmod	previously,described
R1202	T4237	T4238	punct	[,10
R1203	T4238	T4220	parataxis	10,monitored
R1204	T4239	T4238	punct	],10
R1205	T4240	T4220	punct	.,monitored
R1206	T4242	T4243	nummod	Eight,week
R1207	T4243	T4245	npadvmod	week,old
R1208	T4244	T4243	punct	-,week
R1209	T4245	T4246	amod	old,mice
R1210	T4246	T4254	nsubjpass	mice,used
R1211	T4247	T4248	nmod	FVB,N
R1212	T4248	T4246	nmod	N,mice
R1214	T4250	T4248	cc	and,N
R1215	T4251	T4252	compound	DBA,1J
R1216	T4252	T4248	conj	1J,N
R1218	T4255	T4254	auxpass	were,used
R1219	T4256	T4254	prep	for,used
R1220	T4257	T4258	det	the,detection
R1221	T4258	T4256	pobj	detection,for
R1222	T4259	T4258	prep	of,detection
R1223	T4260	T4261	compound	gene,expression
R1224	T4261	T4259	pobj	expression,of
R1225	T4262	T4254	punct	.,used
R1226	T4264	T4265	nsubjpass	They,divided
R1227	T4266	T4265	auxpass	were,divided
R1228	T4267	T4265	prep	into,divided
R1229	T4268	T4269	nummod	four,groups
R1230	T4269	T4267	pobj	groups,into
R1231	T4270	T4269	amod	experimental,groups
R1232	T4271	T4265	prep	according,divided
R1233	T4272	T4271	prep	to,according
R1234	T4273	T4274	det	the,phases
R1235	T4274	T4272	pobj	phases,to
R1236	T4275	T4274	amod	different,phases
R1237	T4276	T4274	prep	of,phases
R1238	T4277	T4276	pobj	CIA,of
R1239	T4278	T4274	punct	", ",phases
R1240	T4279	T4280	advmod	namely,control
R1241	T4280	T4274	appos	control,phases
R1242	T4281	T4280	amod	naive,control
R1243	T4282	T4280	punct	(,control
R1244	T4283	T4280	appos	NC,control
R1245	T4284	T4280	punct	),control
R1246	T4285	T4280	punct	", ",control
R1247	T4286	T4280	conj	post-immunisation,control
R1248	T4287	T4286	punct	(,post-immunisation
R1249	T4288	T4286	appos	PI,post-immunisation
R1250	T4289	T4286	punct	),post-immunisation
R1251	T4290	T4286	punct	", ",post-immunisation
R1252	T4291	T4286	conj	onset,post-immunisation
R1253	T4292	T4291	prep	of,onset
R1254	T4293	T4292	pobj	arthritis,of
R1255	T4294	T4291	punct	(,onset
R1256	T4295	T4291	appos	OA,onset
R1257	T4296	T4291	punct	),onset
R1258	T4297	T4291	cc	and,onset
R1259	T4298	T4299	amod	chronic,arthritis
R1260	T4299	T4291	conj	arthritis,onset
R1261	T4300	T4299	punct	(,arthritis
R1262	T4301	T4299	appos	CA,arthritis
R1263	T4302	T4299	punct	),arthritis
R1264	T4303	T4304	punct	(,Table
R1265	T4304	T4265	parataxis	Table,divided
R1266	T4305	T4304	nummod	1,Table
R1267	T4306	T4304	punct	),Table
R1268	T4307	T4265	punct	.,divided
R1269	T4309	T4310	det	The,group
R1270	T4310	T4312	nsubj	group,contained
R1271	T4311	T4310	compound	NC,group
R1272	T4313	T4314	amod	non-immunised,mice
R1273	T4314	T4312	dobj	mice,contained
R1274	T4315	T4316	dep	that,sacrificed
R1275	T4316	T4314	relcl	sacrificed,mice
R1276	T4317	T4316	auxpass	were,sacrificed
R1277	T4318	T4316	prep	at,sacrificed
R1278	T4319	T4320	det	the,age
R1279	T4320	T4318	pobj	age,at
R1280	T4321	T4320	prep	of,age
R1281	T4322	T4323	nummod	8,weeks
R1282	T4323	T4321	pobj	weeks,of
R1283	T4324	T4312	punct	.,contained
R1284	T4326	T4327	det	The,mice
R1285	T4327	T4328	nsubjpass	mice,sacrificed
R1286	T4329	T4327	prep	in,mice
R1287	T4330	T4331	det	the,group
R1288	T4331	T4329	pobj	group,in
R1289	T4332	T4331	compound	PI,group
R1290	T4333	T4328	auxpass	were,sacrificed
R1291	T4334	T4328	prep	on,sacrificed
R1292	T4335	T4334	pobj	day,on
R1293	T4336	T4335	nummod	10,day
R1294	T4337	T4335	prep	after,day
R1295	T4338	T4337	pobj	immunisation,after
R1296	T4339	T4328	punct	.,sacrificed
R1297	T4341	T4342	det	The,mice
R1298	T4342	T4343	nsubjpass	mice,sacrificed
R1299	T4344	T4342	prep	in,mice
R1300	T4345	T4346	det	the,group
R1301	T4346	T4344	pobj	group,in
R1302	T4347	T4346	compound	OA,group
R1303	T4348	T4343	auxpass	were,sacrificed
R1304	T4349	T4343	prep	on,sacrificed
R1305	T4350	T4349	pobj	day,on
R1306	T4351	T4350	nummod	35,day
R1307	T4352	T4350	prep	after,day
R1308	T4353	T4352	pobj	immunisation,after
R1309	T4354	T4343	punct	.,sacrificed
R1310	T4356	T4357	nummod	Three,mice
R1311	T4357	T4362	nsubjpass	mice,sacrificed
R1312	T4358	T4359	nmod	FVB,N
R1313	T4359	T4357	nmod	N,mice
R1315	T4361	T4357	amod	non-arthritic,mice
R1316	T4363	T4357	cc	and,mice
R1317	T4364	T4365	nummod	three,mice
R1318	T4365	T4357	conj	mice,mice
R1319	T4366	T4365	nmod	DBA,mice
R1320	T4367	T4366	punct	/,DBA
R1321	T4368	T4366	nummod	1,DBA
R1322	T4369	T4370	dep	that,showed
R1323	T4370	T4365	relcl	showed,mice
R1324	T4371	T4370	dobj	signs,showed
R1325	T4372	T4371	prep	of,signs
R1326	T4373	T4372	pobj	arthritis,of
R1327	T4374	T4370	prep	on,showed
R1328	T4375	T4376	nmod	day,33
R1329	T4376	T4374	pobj	33,on
R1330	T4377	T4376	cc	or,33
R1331	T4378	T4376	conj	34,33
R1332	T4379	T4376	prep	after,33
R1333	T4380	T4379	pobj	immunisation,after
R1334	T4381	T4362	auxpass	were,sacrificed
R1335	T4382	T4362	prep	on,sacrificed
R1336	T4383	T4382	pobj	day,on
R1337	T4384	T4383	nummod	35,day
R1338	T4385	T4383	prep	after,day
R1339	T4386	T4385	pobj	immunisation,after
R1340	T4387	T4362	punct	.,sacrificed
R1341	T4389	T4390	det	The,mice
R1342	T4390	T4391	nsubjpass	mice,sacrificed
R1343	T4392	T4390	prep	in,mice
R1344	T4393	T4394	det	the,group
R1345	T4394	T4392	pobj	group,in
R1346	T4395	T4394	compound	CA,group
R1347	T4396	T4391	auxpass	were,sacrificed
R1348	T4397	T4391	prep	on,sacrificed
R1349	T4398	T4397	pobj	day,on
R1350	T4399	T4398	nummod	95,day
R1351	T4400	T4398	prep	after,day
R1352	T4401	T4400	pobj	immunisation,after
R1353	T4402	T4391	punct	.,sacrificed
R1354	T4404	T4405	nummod	Three,mice
R1355	T4405	T4410	nsubjpass	mice,sacrificed
R1356	T4406	T4405	amod	non-arthritic,mice
R1357	T4407	T4408	compound	FVB,N
R1358	T4408	T4405	compound	N,mice
R1360	T4411	T4405	cc	and,mice
R1361	T4412	T4413	nummod	three,mice
R1362	T4413	T4405	conj	mice,mice
R1363	T4414	T4413	nmod	DBA,mice
R1364	T4415	T4414	punct	/,DBA
R1365	T4416	T4414	nummod	1,DBA
R1366	T4417	T4418	dep	that,developed
R1367	T4418	T4413	relcl	developed,mice
R1368	T4419	T4418	aux	had,developed
R1369	T4420	T4418	dobj	arthritis,developed
R1370	T4421	T4418	prep	for,developed
R1371	T4422	T4423	advmod	at,two
R1372	T4423	T4425	nummod	two,months
R1373	T4424	T4423	advmod	least,two
R1374	T4425	T4421	pobj	months,for
R1375	T4426	T4410	auxpass	were,sacrificed
R1376	T4427	T4410	prep	on,sacrificed
R1377	T4428	T4427	pobj	day,on
R1378	T4429	T4428	nummod	95,day
R1379	T4430	T4428	prep	after,day
R1380	T4431	T4430	pobj	immunisation,after
R1381	T4432	T4410	punct	.,sacrificed
R1382	T4628	T4629	compound	Linkage,analysis
R1383	T4631	T4632	amod	Detailed,information
R1384	T4632	T4633	nsubjpass	information,described
R1385	T4634	T4632	prep	on,information
R1386	T4635	T4634	pobj	genotyping,on
R1387	T4636	T4635	prep	of,genotyping
R1388	T4637	T4638	det	the,screen
R1389	T4638	T4636	pobj	screen,of
R1390	T4639	T4638	compound	genome,screen
R1391	T4640	T4633	aux	has,described
R1392	T4641	T4633	auxpass	been,described
R1393	T4642	T4633	advmod	previously,described
R1394	T4643	T4644	punct	[,10
R1395	T4644	T4633	parataxis	10,described
R1396	T4645	T4644	punct	],10
R1397	T4646	T4633	punct	.,described
R1398	T4648	T4649	prep	In,genotyped
R1399	T4650	T4648	amod	short,In
R1400	T4651	T4649	punct	", ",genotyped
R1401	T4652	T4649	nsubj	we,genotyped
R1402	T4653	T4654	nummod	290,mice
R1403	T4654	T4649	dobj	mice,genotyped
R1404	T4655	T4654	compound	F2,mice
R1405	T4656	T4649	advcl	using,genotyped
R1406	T4657	T4658	nummod	126,markers
R1407	T4658	T4656	dobj	markers,using
R1408	T4659	T4658	amod	informative,markers
R1409	T4660	T4658	compound	microsatellite,markers
R1410	T4661	T4658	acl	covering,markers
R1411	T4662	T4663	det	the,genome
R1412	T4663	T4661	dobj	genome,covering
R1413	T4664	T4661	prep	with,covering
R1414	T4665	T4666	det	an,distance
R1415	T4666	T4664	pobj	distance,with
R1416	T4667	T4666	amod	average,distance
R1417	T4668	T4666	amod	inter-marker,distance
R1418	T4669	T4666	prep	of,distance
R1419	T4670	T4671	nummod	11.5,cM
R1420	T4671	T4669	pobj	cM,of
R1421	T4672	T4666	prep	for,distance
R1422	T4673	T4674	nummod	290,progeny
R1423	T4674	T4672	pobj	progeny,for
R1424	T4675	T4674	compound	F2,progeny
R1425	T4676	T4649	punct	.,genotyped
R1426	T4678	T4679	det	All,analyses
R1427	T4679	T4681	nsubjpass	analyses,performed
R1428	T4680	T4679	compound	linkage,analyses
R1429	T4682	T4681	auxpass	were,performed
R1430	T4683	T4681	prep	with,performed
R1431	T4684	T4685	compound	QTX,software
R1432	T4685	T4683	pobj	software,with
R1433	T4686	T4687	compound	Map,manager
R1434	T4687	T4685	compound	manager,software
R1435	T4688	T4689	punct	[,23
R1436	T4689	T4681	parataxis	23,performed
R1437	T4690	T4689	punct	],23
R1438	T4691	T4681	punct	.,performed
R1439	T4693	T4694	det	The,phenotype
R1440	T4694	T4697	nsubjpass	phenotype,taken
R1441	T4695	T4694	amod	main,phenotype
R1442	T4696	T4694	amod	clinical,phenotype
R1443	T4698	T4694	prep	of,phenotype
R1444	T4699	T4698	pobj	CIA,of
R1445	T4700	T4694	punct	", ",phenotype
R1446	T4701	T4702	compound	arthritis,severity
R1447	T4702	T4694	appos	severity,phenotype
R1448	T4703	T4697	punct	", ",taken
R1449	T4704	T4697	auxpass	was,taken
R1450	T4705	T4697	prep	as,taken
R1451	T4706	T4705	pobj	phenotype,as
R1452	T4707	T4697	punct	.,taken
R1453	T4709	T4710	aux	To,detect
R1454	T4710	T4711	advcl	detect,set
R1455	T4712	T4713	det	the,QTL
R1456	T4713	T4710	dobj	QTL,detect
R1457	T4714	T4715	amod	small,effect
R1458	T4715	T4713	compound	effect,QTL
R1460	T4717	T4711	punct	", ",set
R1461	T4718	T4719	det	the,value
R1462	T4719	T4711	nsubjpass	value,set
R1463	T4720	T4719	compound	threshold,value
R1464	T4721	T4719	prep	of,value
R1465	T4722	T4721	pobj	linkage,of
R1466	T4723	T4711	auxpass	was,set
R1467	T4724	T4711	prep	as,set
R1468	T4725	T4726	nsubj	P,0.05
R1469	T4726	T4724	pcomp	0.05,as
R1470	T4727	T4726	punct	=,0.05
R1471	T4728	T4729	punct	(,test
R1472	T4729	T4726	parataxis	test,0.05
R1473	T4730	T4731	compound	Chi,square
R1474	T4731	T4729	compound	square,test
R1476	T4733	T4729	punct	),test
R1477	T4734	T4711	punct	.,set
R1478	T5000	T5001	compound	Sample,preparation
R1479	T5002	T5001	cc	and,preparation
R1480	T5003	T5004	compound	microarray,hybridisation
R1481	T5004	T5001	conj	hybridisation,preparation
R1482	T5006	T5007	compound	Lymph,nodes
R1483	T5007	T5008	nsubjpass	nodes,used
R1484	T5009	T5007	punct	(,nodes
R1485	T5010	T5007	appos	LNs,nodes
R1486	T5011	T5007	punct	),nodes
R1487	T5012	T5007	acl	draining,nodes
R1488	T5013	T5014	det	the,site
R1489	T5014	T5012	dobj	site,draining
R1490	T5015	T5014	compound	immunisation,site
R1491	T5016	T5008	auxpass	were,used
R1492	T5017	T5008	prep	for,used
R1493	T5018	T5019	amod	total,preparation
R1494	T5019	T5017	pobj	preparation,for
R1495	T5020	T5019	compound	RNA,preparation
R1496	T5021	T5008	punct	.,used
R1497	T5023	T5024	det	The,RNA
R1498	T5024	T5026	nsubjpass	RNA,extracted
R1499	T5025	T5024	amod	total,RNA
R1500	T5027	T5026	auxpass	was,extracted
R1501	T5028	T5026	prep	from,extracted
R1502	T5029	T5030	det	the,homogenates
R1503	T5030	T5028	pobj	homogenates,from
R1504	T5031	T5030	compound	tissue,homogenates
R1505	T5032	T5026	advcl	using,extracted
R1506	T5033	T5034	det	a,kit
R1507	T5034	T5032	dobj	kit,using
R1508	T5035	T5034	amod	commercial,kit
R1509	T5036	T5026	prep	in,extracted
R1510	T5037	T5036	pobj	accordance,in
R1511	T5038	T5037	prep	with,accordance
R1512	T5039	T5040	det	the,protocol
R1513	T5040	T5038	pobj	protocol,with
R1514	T5041	T5040	amod	provided,protocol
R1515	T5042	T5043	punct	(,QIGEN
R1516	T5043	T5026	parataxis	QIGEN,extracted
R1517	T5044	T5043	punct	", ",QIGEN
R1518	T5045	T5043	npadvmod	Hilden,QIGEN
R1519	T5046	T5043	punct	", ",QIGEN
R1520	T5047	T5043	npadvmod	Germany,QIGEN
R1521	T5048	T5043	punct	),QIGEN
R1522	T5049	T5026	punct	.,extracted
R1523	T5051	T5052	nsubjpass	Analysis,conducted
R1524	T5053	T5051	prep	of,Analysis
R1525	T5054	T5055	compound	gene,expression
R1526	T5055	T5053	pobj	expression,of
R1527	T5056	T5052	auxpass	was,conducted
R1528	T5057	T5052	advcl	using,conducted
R1529	T5058	T5059	det	a,array
R1530	T5059	T5057	dobj	array,using
R1531	T5060	T5059	compound	U430A,array
R1532	T5061	T5062	punct	(,Affymetrix
R1533	T5062	T5059	parataxis	Affymetrix,array
R1534	T5063	T5062	punct	", ",Affymetrix
R1535	T5064	T5065	compound	Santa,Clara
R1536	T5065	T5062	npadvmod	Clara,Affymetrix
R1537	T5066	T5062	punct	", ",Affymetrix
R1538	T5067	T5062	npadvmod	CA,Affymetrix
R1539	T5068	T5062	punct	", ",Affymetrix
R1540	T5069	T5062	npadvmod	USA,Affymetrix
R1541	T5070	T5062	punct	),Affymetrix
R1542	T5071	T5059	acl	interrogating,array
R1543	T5072	T5073	amod	more,"22,000"
R1544	T5073	T5075	nummod	"22,000",genes
R1545	T5074	T5073	quantmod	than,"22,000"
R1546	T5075	T5071	dobj	genes,interrogating
R1547	T5076	T5052	punct	.,conducted
R1548	T5078	T5079	compound	RNA,probes
R1549	T5079	T5080	nsubjpass	probes,labelled
R1550	T5081	T5080	auxpass	were,labelled
R1551	T5082	T5080	prep	in,labelled
R1552	T5083	T5082	pobj	accordance,in
R1553	T5084	T5083	prep	with,accordance
R1554	T5085	T5086	det	the,manufacturer
R1555	T5086	T5087	poss	manufacturer,instructions
R1556	T5087	T5084	pobj	instructions,with
R1557	T5088	T5086	case	's,manufacturer
R1558	T5089	T5080	punct	.,labelled
R1559	T5091	T5092	nsubjpass	Samples,hybridised
R1560	T5093	T5091	prep	from,Samples
R1561	T5094	T5095	amod	individual,mice
R1562	T5095	T5093	pobj	mice,from
R1563	T5096	T5092	auxpass	were,hybridised
R1564	T5097	T5092	prep	onto,hybridised
R1565	T5098	T5099	amod	individual,arrays
R1566	T5099	T5097	pobj	arrays,onto
R1567	T5100	T5092	punct	.,hybridised
R1568	T5102	T5103	nsubjpass	Hybridisation,done
R1569	T5104	T5102	cc	and,Hybridisation
R1570	T5105	T5102	conj	washing,Hybridisation
R1571	T5106	T5102	prep	of,Hybridisation
R1572	T5107	T5108	compound	gene,chips
R1573	T5108	T5106	pobj	chips,of
R1574	T5109	T5103	auxpass	were,done
R1575	T5110	T5111	mark	as,described
R1576	T5111	T5103	advcl	described,done
R1577	T5112	T5111	advmod	previously,described
R1578	T5113	T5114	punct	[,16
R1579	T5114	T5103	parataxis	16,done
R1580	T5115	T5114	punct	],16
R1581	T5116	T5103	punct	.,done
R1582	T5118	T5119	amod	Fluorescent,signals
R1583	T5119	T5120	nsubjpass	signals,collected
R1584	T5121	T5120	auxpass	were,collected
R1585	T5122	T5120	prep	by,collected
R1586	T5123	T5124	compound	laser,scan
R1587	T5124	T5122	pobj	scan,by
R1588	T5125	T5126	punct	(,Scanner
R1589	T5126	T5124	parataxis	Scanner,scan
R1590	T5127	T5128	compound	Hewlett,Packard
R1591	T5128	T5126	compound	Packard,Scanner
R1593	T5130	T5126	compound	Gene,Scanner
R1594	T5131	T5126	punct	),Scanner
R1595	T5132	T5120	punct	.,collected
R1596	T5603	T5604	compound	Microarray,analysis
R1597	T5606	T5607	nsubjpass	Normalisation,done
R1598	T5608	T5606	prep	of,Normalisation
R1599	T5609	T5610	det	the,level
R1600	T5610	T5608	pobj	level,of
R1601	T5611	T5610	compound	expression,level
R1602	T5612	T5607	auxpass	was,done
R1603	T5613	T5607	advcl	using,done
R1604	T5614	T5615	compound	Affymetrix,MAS
R1605	T5615	T5613	dobj	MAS,using
R1606	T5616	T5615	compound	software,MAS
R1607	T5617	T5615	nummod	5,MAS
R1608	T5618	T5615	punct	", ",MAS
R1609	T5619	T5620	dep	which,based
R1610	T5620	T5615	relcl	based,MAS
R1611	T5621	T5620	auxpass	is,based
R1612	T5622	T5620	prep	on,based
R1613	T5623	T5624	amod	global,scaling
R1614	T5624	T5622	pobj	scaling,on
R1615	T5625	T5624	prep	of,scaling
R1616	T5626	T5627	amod	total,level
R1617	T5627	T5625	pobj	level,of
R1618	T5628	T5629	compound	gene,expression
R1619	T5629	T5627	compound	expression,level
R1620	T5630	T5627	prep	per,level
R1621	T5631	T5630	pobj	microarray,per
R1622	T5632	T5607	punct	.,done
R1623	T5634	T5635	det	The,values
R1624	T5635	T5638	nsubjpass	values,imported
R1625	T5636	T5635	amod	normalised,values
R1626	T5637	T5635	compound	expression,values
R1627	T5639	T5638	auxpass	were,imported
R1628	T5640	T5638	prep	to,imported
R1629	T5641	T5638	cc	and,imported
R1630	T5642	T5638	conj	analysed,imported
R1631	T5643	T5642	prep	by,analysed
R1632	T5644	T5642	dobj	dCHIP,analysed
R1633	T5645	T5646	punct	[,24
R1634	T5646	T5642	parataxis	24,analysed
R1635	T5647	T5646	punct	],24
R1636	T5648	T5638	punct	.,imported
R1637	T5650	T5651	advmod	Differentially,expressed
R1638	T5651	T5652	amod	expressed,genes
R1639	T5652	T5653	nsubjpass	genes,identified
R1640	T5654	T5653	auxpass	were,identified
R1641	T5655	T5653	prep	by,identified
R1642	T5656	T5655	pcomp	defining,by
R1643	T5657	T5658	det	the,criteria
R1644	T5658	T5656	dobj	criteria,defining
R1645	T5659	T5658	amod	appropriate,criteria
R1646	T5660	T5658	compound	filtering,criteria
R1647	T5661	T5656	prep	in,defining
R1648	T5662	T5663	det	the,software
R1649	T5663	T5661	pobj	software,in
R1650	T5664	T5663	compound	dCHIP,software
R1651	T5665	T5656	prep	as,defining
R1652	T5666	T5665	punct	: ,as
R1653	T5667	T5668	amod	lower,%
R1654	T5668	T5670	compound	%,boundary
R1655	T5669	T5668	nummod	90,%
R1656	T5670	T5672	nsubj	boundary,exceeded
R1657	T5671	T5670	compound	confidence,boundary
R1658	T5672	T5680	ccomp	exceeded,was
R1659	T5673	T5670	prep	of,boundary
R1660	T5674	T5675	compound	fold,change
R1661	T5675	T5673	pobj	change,of
R1662	T5676	T5670	prep	between,boundary
R1663	T5677	T5678	det	the,means
R1664	T5678	T5676	pobj	means,between
R1666	T5680	T5665	pcomp	was,as
R1667	T5681	T5672	advmod	twofold,exceeded
R1668	T5682	T5680	punct	;,was
R1669	T5683	T5684	det	the,difference
R1670	T5684	T5686	nsubj	difference,exceeded
R1672	T5686	T5680	ccomp	exceeded,was
R1675	T5689	T5687	pobj	groups,between
R1676	T5690	T5689	nummod	two,groups
R1677	T5691	T5686	dobj	100,exceeded
R1678	T5692	T5680	punct	;,was
R1679	T5693	T5694	det	the,threshold
R1680	T5694	T5680	nsubj	threshold,was
R1683	T5697	T5694	prep	of,threshold
R1684	T5698	T5699	det	the,test
R1685	T5699	T5697	pobj	test,of
R1689	T5703	T5680	attr	0.05,was
R1690	T5704	T5653	punct	.,identified
R1691	T5706	T5707	det	The,rate
R1692	T5707	T5710	nsubjpass	rate,established
R1693	T5708	T5709	amod	false,discovery
R1694	T5709	T5707	compound	discovery,rate
R1695	T5711	T5710	auxpass	was,established
R1696	T5712	T5710	prep	with,established
R1697	T5713	T5714	det	a,test
R1698	T5714	T5712	pobj	test,with
R1699	T5715	T5714	compound	permutation,test
R1700	T5716	T5714	prep	for,test
R1701	T5717	T5718	det	each,comparison
R1702	T5718	T5716	pobj	comparison,for
R1703	T5719	T5718	amod	pairwise,comparison
R1704	T5720	T5721	aux	to,estimate
R1705	T5721	T5710	advcl	estimate,established
R1706	T5722	T5723	det	the,proportion
R1707	T5723	T5721	dobj	proportion,estimate
R1708	T5724	T5723	prep	of,proportion
R1709	T5725	T5726	amod	false,positive
R1710	T5726	T5728	amod	positive,genes
R1711	T5727	T5726	punct	-,positive
R1712	T5728	T5724	pobj	genes,of
R1713	T5729	T5710	punct	.,established
R1714	T5731	T5732	amod	Hierarchical,clustering
R1715	T5732	T5734	nsubjpass	clustering,performed
R1716	T5733	T5732	compound	gene,clustering
R1717	T5735	T5734	auxpass	was,performed
R1718	T5736	T5734	prep	with,performed
R1719	T5737	T5736	pobj	dCHIP,with
R1720	T5738	T5739	aux	to,characterise
R1721	T5739	T5734	advcl	characterise,performed
R1722	T5740	T5741	det	the,patterns
R1723	T5741	T5739	dobj	patterns,characterise
R1724	T5742	T5743	compound	gene,expression
R1725	T5743	T5741	compound	expression,patterns
R1726	T5744	T5741	prep	during,patterns
R1727	T5745	T5744	pobj	CIA,during
R1728	T5746	T5734	punct	.,performed
R1729	T5748	T5749	det	The,algorithm
R1730	T5749	T5752	nsubj	algorithm,was
R1731	T5750	T5749	compound	default,algorithm
R1732	T5751	T5749	compound	clustering,algorithm
R1733	T5752	T5755	ccomp	was,defined
R1734	T5753	T5749	prep	of,algorithm
R1735	T5754	T5753	pobj	genes,of
R1736	T5756	T5757	mark	as,follows
R1737	T5757	T5752	advcl	follows,was
R1738	T5758	T5755	punct	: ,defined
R1739	T5759	T5760	det	the,distance
R1740	T5760	T5755	nsubjpass	distance,defined
R1741	T5761	T5760	prep	between,distance
R1742	T5762	T5763	nummod	two,genes
R1743	T5763	T5761	pobj	genes,between
R1744	T5764	T5755	auxpass	is,defined
R1745	T5765	T5755	prep	as,defined
R1746	T5766	T5767	nummod	1,r
R1747	T5767	T5765	pobj	r,as
R1748	T5768	T5767	punct	–,r
R1749	T5769	T5767	punct	", ",r
R1750	T5770	T5771	advmod	where,is
R1751	T5771	T5767	relcl	is,r
R1752	T5772	T5771	nsubj	r,is
R1753	T5773	T5774	det	the,coefficient
R1754	T5774	T5771	attr	coefficient,is
R1755	T5775	T5774	compound	Pearson,coefficient
R1756	T5776	T5774	compound	correlation,coefficient
R1757	T5777	T5774	prep	between,coefficient
R1758	T5778	T5779	det	the,values
R1759	T5779	T5777	pobj	values,between
R1760	T5780	T5779	amod	standardised,values
R1761	T5781	T5779	compound	expression,values
R1762	T5782	T5779	prep	of,values
R1763	T5783	T5784	det	the,genes
R1764	T5784	T5782	pobj	genes,of
R1765	T5785	T5784	nummod	two,genes
R1766	T5786	T5784	prep	across,genes
R1767	T5787	T5788	det	the,samples
R1768	T5788	T5786	pobj	samples,across
R1769	T5789	T5788	acl	used,samples
R1770	T5790	T5755	punct	.,defined
R1771	T5792	T5793	aux	To,characterise
R1772	T5793	T5794	advcl	characterise,performed
R1773	T5795	T5796	det	the,relationship
R1774	T5796	T5793	dobj	relationship,characterise
R1775	T5797	T5796	amod	functional,relationship
R1776	T5798	T5796	prep	between,relationship
R1777	T5799	T5800	advmod	differentially,genes
R1778	T5800	T5798	pobj	genes,between
R1779	T5801	T5800	amod	expressed,genes
R1780	T5802	T5794	punct	", ",performed
R1781	T5803	T5804	nmod	Gene,Ontology
R1782	T5804	T5805	nmod	Ontology,classification
R1783	T5805	T5794	nsubjpass	classification,performed
R1784	T5806	T5804	punct	(,Ontology
R1785	T5807	T5804	appos	GO,Ontology
R1786	T5808	T5805	punct	),classification
R1787	T5809	T5805	compound	term,classification
R1788	T5810	T5805	acl	incorporated,classification
R1789	T5811	T5810	prep	in,incorporated
R1790	T5812	T5813	compound	DNA,Chip
R1791	T5813	T5815	compound	Chip,Analyzer
R1792	T5814	T5813	punct	-,Chip
R1793	T5815	T5811	pobj	Analyzer,in
R1794	T5816	T5794	auxpass	was,performed
R1795	T5817	T5794	punct	.,performed
R1796	T5819	T5820	det	The,level
R1797	T5820	T5822	nsubjpass	level,set
R1798	T5821	T5820	amod	significant,level
R1799	T5823	T5820	prep	for,level
R1800	T5824	T5825	det	a,cluster
R1801	T5825	T5823	pobj	cluster,for
R1802	T5826	T5825	compound	function,cluster
R1803	T5827	T5822	auxpass	was,set
R1804	T5828	T5822	prep	at,set
R1805	T5829	T5828	pobj	P,at
R1806	T5830	T5831	punct	<,0.005
R1807	T5831	T5829	amod	0.005,P
R1808	T5832	T5822	punct	", ",set
R1809	T5833	T5822	cc	and,set
R1810	T5834	T5835	det	the,size
R1811	T5835	T5837	nsubj	size,was
R1812	T5836	T5835	amod	minimum,size
R1813	T5837	T5822	conj	was,set
R1814	T5838	T5835	prep	of,size
R1815	T5839	T5840	det	a,cluster
R1816	T5840	T5838	pobj	cluster,of
R1817	T5841	T5842	nummod	three,genes
R1818	T5842	T5837	attr	genes,was
R1819	T5843	T5837	punct	.,was
R1824	T7078	T7079	amod	Small,effect
R1825	T7079	T7081	compound	effect,QTL
R1826	T7080	T7079	punct	-,effect
R1827	T7082	T7081	prep	of,QTL
R1828	T7083	T7082	pobj	CIA,of
R1829	T7084	T7081	prep	in,QTL
R1830	T7085	T7086	punct	(,DBA
R1831	T7086	T7087	nmod	DBA,progeny
R1832	T7087	T7084	pobj	progeny,in
R1833	T7088	T7086	punct	/,DBA
R1834	T7089	T7086	nummod	1,DBA
R1835	T7090	T7086	punct	×,DBA
R1836	T7091	T7092	compound	FVB,N
R1837	T7092	T7086	appos	N,DBA
R1838	T7093	T7092	punct	/,N
R1839	T7094	T7086	punct	),DBA
R1840	T7095	T7087	compound	F2,progeny
R1841	T7097	T7098	prep	In,carried
R1842	T7099	T7100	det	a,study
R1843	T7100	T7097	pobj	study,In
R1844	T7101	T7100	amod	previous,study
R1845	T7102	T7098	punct	", ",carried
R1846	T7103	T7098	nsubj	we,carried
R1847	T7104	T7098	prt	out,carried
R1848	T7105	T7106	det	a,screen
R1849	T7106	T7098	dobj	screen,carried
R1850	T7107	T7106	compound	genome,screen
R1851	T7108	T7109	aux	to,identify
R1852	T7109	T7098	advcl	identify,carried
R1853	T7110	T7109	dobj	QTL,identify
R1854	T7111	T7110	acl	controlling,QTL
R1855	T7112	T7113	compound	CIA,susceptibility
R1856	T7113	T7111	dobj	susceptibility,controlling
R1857	T7114	T7111	prep	in,controlling
R1858	T7115	T7116	punct	(,DBA
R1859	T7116	T7117	nmod	DBA,progeny
R1860	T7117	T7114	pobj	progeny,in
R1861	T7118	T7116	punct	/,DBA
R1862	T7119	T7116	nummod	1,DBA
R1863	T7120	T7121	punct	×,N
R1864	T7121	T7116	prep	N,DBA
R1865	T7122	T7121	compound	FVB,N
R1866	T7123	T7121	punct	/,N
R1867	T7124	T7116	punct	),DBA
R1868	T7125	T7117	compound	F2,progeny
R1869	T7126	T7098	punct	.,carried
R1870	T7128	T7129	prep	For,identified
R1871	T7130	T7131	det	the,phenotype
R1872	T7131	T7128	pobj	phenotype,For
R1873	T7132	T7131	prep	of,phenotype
R1874	T7133	T7134	compound	arthritis,severity
R1875	T7134	T7132	pobj	severity,of
R1876	T7135	T7129	punct	", ",identified
R1877	T7136	T7137	advmod	only,QTL
R1878	T7137	T7129	nsubjpass	QTL,identified
R1879	T7138	T7137	nummod	one,QTL
R1880	T7139	T7137	punct	", ",QTL
R1881	T7140	T7137	appos	Cia2,QTL
R1882	T7141	T7129	punct	", ",identified
R1883	T7142	T7129	auxpass	was,identified
R1884	T7143	T7129	punct	", ",identified
R1885	T7144	T7129	prep	with,identified
R1886	T7145	T7146	det	a,score
R1887	T7146	T7144	pobj	score,with
R1888	T7147	T7148	advmod	highly,significant
R1889	T7148	T7146	amod	significant,score
R1890	T7149	T7146	nmod	logarithm,score
R1891	T7150	T7149	prep	of,logarithm
R1892	T7151	T7152	det	the,odds
R1893	T7152	T7150	pobj	odds,of
R1894	T7153	T7149	punct	(,logarithm
R1895	T7154	T7149	appos	LOD,logarithm
R1896	T7155	T7146	punct	),score
R1897	T7156	T7146	prep	of,score
R1898	T7157	T7156	pobj	12,of
R1899	T7158	T7159	punct	[,10
R1900	T7159	T7129	parataxis	10,identified
R1901	T7160	T7159	punct	],10
R1902	T7161	T7129	punct	.,identified
R1903	T7163	T7164	advmod	However,contributed
R1904	T7165	T7164	punct	", ",contributed
R1905	T7166	T7164	nsubj	Cia2,contributed
R1906	T7167	T7164	prep	to,contributed
R1907	T7168	T7169	advmod	only,%
R1908	T7169	T7167	pobj	%,to
R1909	T7170	T7169	nummod	16,%
R1910	T7171	T7169	prep	of,%
R1911	T7172	T7173	det	the,variations
R1912	T7173	T7171	pobj	variations,of
R1913	T7174	T7173	compound	phenotype,variations
R1914	T7175	T7164	punct	", ",contributed
R1915	T7176	T7164	advcl	indicating,contributed
R1916	T7177	T7178	mark	that,be
R1918	T7179	T7178	expl	there,be
R1919	T7180	T7178	aux	should,be
R1920	T7181	T7182	det	some,QTL
R1921	T7182	T7178	attr	QTL,be
R1922	T7183	T7184	amod	small,effect
R1923	T7184	T7182	compound	effect,QTL
R1924	T7185	T7184	punct	-,effect
R1925	T7186	T7187	poss	whose,contributions
R1926	T7187	T7188	dep	contributions,were
R1928	T7189	T7187	prep	to,contributions
R1929	T7190	T7189	pobj	CIA,to
R1930	T7191	T7188	neg	not,were
R1931	T7192	T7188	acomp	big,were
R1932	T7193	T7192	advmod	enough,big
R1933	T7194	T7195	aux	to,reach
R1934	T7195	T7192	xcomp	reach,big
R1935	T7196	T7197	det	the,value
R1937	T7198	T7199	amod	significant,threshold
R1938	T7199	T7197	compound	threshold,value
R1939	T7200	T7197	prep	of,value
R1940	T7201	T7200	pobj	linkage,of
R1941	T7202	T7164	punct	.,contributed
R1942	T7204	T7205	aux	To,identify
R1943	T7205	T7206	advcl	identify,reanalyzed
R1944	T7207	T7208	det	these,QTL
R1945	T7208	T7205	dobj	QTL,identify
R1946	T7209	T7208	amod	potential,QTL
R1947	T7210	T7211	amod	small,effect
R1948	T7211	T7208	compound	effect,QTL
R1949	T7212	T7211	punct	-,effect
R1950	T7213	T7206	punct	", ",reanalyzed
R1951	T7214	T7206	nsubj	we,reanalyzed
R1952	T7215	T7216	det	the,data
R1953	T7216	T7206	dobj	data,reanalyzed
R1954	T7217	T7206	advcl	using,reanalyzed
R1955	T7218	T7219	det	a,value
R1957	T7220	T7221	amod	lower,threshold
R1958	T7221	T7219	compound	threshold,value
R1959	T7222	T7219	prep	of,value
R1960	T7223	T7222	pobj	linkage,of
R1961	T7224	T7225	punct	(,0.05
R1963	T7226	T7225	nsubj	P,0.05
R1964	T7227	T7225	punct	=,0.05
R1965	T7228	T7225	punct	),0.05
R1966	T7229	T7206	punct	.,reanalyzed
R1967	T7231	T7232	nsubj	We,reasoned
R1968	T7233	T7234	mark	that,masked
R1969	T7234	T7232	ccomp	masked,reasoned
R1970	T7235	T7236	mark	since,proven
R1971	T7236	T7234	advcl	proven,masked
R1972	T7237	T7238	det	the,gene
R1973	T7238	T7236	nsubjpass	gene,proven
R1974	T7239	T7238	amod	main,gene
R1975	T7240	T7238	compound	candidate,gene
R1976	T7241	T7238	prep	of,gene
R1977	T7242	T7241	pobj	Cia2,of
R1978	T7243	T7238	punct	", ",gene
R1979	T7244	T7245	compound	complement,C5
R1980	T7245	T7238	appos	C5,gene
R1981	T7246	T7245	compound	component,C5
R1982	T7247	T7248	punct	(,Hc
R1983	T7248	T7245	parataxis	Hc,C5
R1984	T7249	T7248	punct	),Hc
R1985	T7250	T7236	punct	", ",proven
R1986	T7251	T7236	auxpass	was,proven
R1987	T7252	T7253	aux	to,be
R1988	T7253	T7236	xcomp	be,proven
R1989	T7254	T7253	acomp	essential,be
R1990	T7255	T7254	prep	for,essential
R1991	T7256	T7257	compound	CIA,development
R1992	T7257	T7255	pobj	development,for
R1993	T7258	T7236	cc	and,proven
R1994	T7259	T7260	mark	because,is
R1995	T7260	T7236	conj	is,proven
R1996	T7261	T7262	det	the,strain
R1997	T7262	T7260	nsubj	strain,is
R1998	T7263	T7264	compound	FVB,N
R1999	T7264	T7262	compound	N,strain
R2000	T7265	T7264	punct	/,N
R2001	T7266	T7267	npadvmod	C5,deficient
R2002	T7267	T7260	acomp	deficient,is
R2003	T7268	T7269	punct	[,25
R2004	T7269	T7260	parataxis	25,is
R2005	T7270	T7269	nummod	10,25
R2006	T7271	T7269	punct	",",25
R2007	T7272	T7269	punct	],25
R2008	T7273	T7234	punct	", ",masked
R2009	T7274	T7275	det	some,QTL
R2011	T7276	T7277	amod	small,effect
R2012	T7277	T7275	compound	effect,QTL
R2013	T7278	T7277	punct	-,effect
R2014	T7279	T7234	aux	might,masked
R2015	T7280	T7234	auxpass	be,masked
R2016	T7281	T7234	agent	by,masked
R2017	T7282	T7281	pobj	Cia2,by
R2018	T7283	T7232	punct	.,reasoned
R2019	T7285	T7286	aux	To,exclude
R2020	T7286	T7287	advcl	exclude,performed
R2021	T7288	T7289	det	the,effect
R2022	T7289	T7286	dobj	effect,exclude
R2023	T7290	T7289	compound	masking,effect
R2024	T7291	T7289	prep	of,effect
R2025	T7292	T7291	pobj	C5,of
R2026	T7293	T7287	punct	", ",performed
R2027	T7294	T7287	nsubj	we,performed
R2028	T7295	T7296	compound	linkage,analysis
R2029	T7296	T7287	dobj	analysis,performed
R2030	T7297	T7287	prep	with,performed
R2031	T7298	T7299	nummod	3,datasets
R2032	T7299	T7297	pobj	datasets,with
R2033	T7300	T7287	punct	", ",performed
R2034	T7301	T7302	det	the,first
R2035	T7302	T7303	nsubj	first,containing
R2036	T7303	T7287	advcl	containing,performed
R2037	T7304	T7305	det	all,progeny
R2039	T7306	T7305	nummod	290,progeny
R2040	T7307	T7305	compound	F2,progeny
R2041	T7308	T7303	punct	", ",containing
R2042	T7309	T7310	det	the,second
R2043	T7310	T7311	nsubj	second,progeny
R2044	T7311	T7303	conj	progeny,containing
R2045	T7312	T7311	nummod	77,progeny
R2046	T7313	T7311	nmod	C5+,progeny
R2047	T7314	T7313	punct	/,C5+
R2048	T7315	T7313	punct	+,C5+
R2049	T7316	T7311	compound	F2,progeny
R2050	T7317	T7311	cc	and,progeny
R2051	T7318	T7319	det	the,third
R2052	T7319	T7320	nsubj	third,progeny
R2053	T7320	T7311	conj	progeny,progeny
R2054	T7321	T7320	nummod	133,progeny
R2055	T7322	T7320	nmod	C5+,progeny
R2056	T7323	T7322	punct	/,C5+
R2057	T7324	T7322	punct	-,C5+
R2058	T7325	T7320	compound	F2,progeny
R2059	T7326	T7287	punct	.,performed
R2060	T7328	T7329	nummod	Eight,regions
R2061	T7329	T7331	nsubjpass	regions,linked
R2062	T7330	T7329	amod	genomic,regions
R2063	T7332	T7331	auxpass	were,linked
R2064	T7333	T7331	prep	to,linked
R2065	T7334	T7335	det	the,phenotype
R2066	T7335	T7333	pobj	phenotype,to
R2067	T7336	T7335	prep	of,phenotype
R2068	T7337	T7338	compound	CIA,severity
R2069	T7338	T7336	pobj	severity,of
R2070	T7339	T7340	punct	(,Table
R2071	T7340	T7331	parataxis	Table,linked
R2072	T7341	T7342	nmod	loci,1
R2073	T7342	T7340	dep	1,Table
R2074	T7343	T7342	prep	to,1
R2075	T7344	T7343	pobj	8,to
R2076	T7345	T7340	punct	", ",Table
R2077	T7346	T7340	nummod	2,Table
R2078	T7347	T7340	punct	),Table
R2079	T7348	T7331	punct	", ",linked
R2080	T7349	T7350	mark	with,varying
R2082	T7351	T7352	compound	P,values
R2083	T7352	T7350	nsubj	values,varying
R2084	T7353	T7350	prep	between,varying
R2085	T7354	T7353	pobj	0.043,between
R2086	T7355	T7354	cc	and,0.043
R2087	T7356	T7354	conj	0.003,0.043
R2088	T7357	T7331	punct	.,linked
R2089	T7359	T7360	det	These,QTL
R2090	T7360	T7365	nsubjpass	QTL,located
R2091	T7361	T7360	nummod	eight,QTL
R2092	T7362	T7363	amod	small,effect
R2093	T7363	T7360	compound	effect,QTL
R2094	T7364	T7363	punct	-,effect
R2095	T7366	T7365	auxpass	were,located
R2096	T7367	T7365	prep	on,located
R2097	T7368	T7369	nmod	chromosomes,5
R2098	T7369	T7367	pobj	5,on
R2099	T7370	T7369	punct	", ",5
R2100	T7371	T7369	conj	6,5
R2101	T7372	T7371	punct	", ",6
R2102	T7373	T7371	conj	7,6
R2103	T7374	T7373	punct	", ",7
R2104	T7375	T7373	conj	10,7
R2105	T7376	T7375	punct	", ",10
R2106	T7377	T7375	conj	11,10
R2107	T7378	T7377	punct	", ",11
R2108	T7379	T7377	conj	16,11
R2109	T7380	T7379	punct	", ",16
R2110	T7381	T7379	cc	and,16
R2111	T7382	T7379	conj	17,16
R2112	T7383	T7365	punct	.,located
R2113	T7385	T7386	nummod	Five,loci
R2114	T7386	T7387	nsubjpass	loci,identified
R2115	T7388	T7387	auxpass	were,identified
R2116	T7389	T7387	prep	in,identified
R2117	T7390	T7391	advmod	at,two
R2118	T7391	T7393	nummod	two,datasets
R2119	T7392	T7391	advmod	least,two
R2120	T7393	T7389	pobj	datasets,in
R2121	T7394	T7387	punct	.,identified
R2122	T7396	T7397	prep	Of,had
R2123	T7398	T7399	det	the,loci
R2124	T7399	T7396	pobj	loci,Of
R2125	T7400	T7399	nummod	eight,loci
R2126	T7401	T7397	punct	", ",had
R2127	T7402	T7397	nsubj	five,had
R2128	T7403	T7397	dobj	DBA,had
R2129	T7404	T7403	punct	/,DBA
R2130	T7405	T7403	nummod	1,DBA
R2131	T7406	T7397	prep	as,had
R2132	T7407	T7408	det	the,allele
R2133	T7408	T7406	pobj	allele,as
R2134	T7409	T7408	compound	susceptibility,allele
R2135	T7410	T7397	punct	", ",had
R2136	T7411	T7397	cc	and,had
R2137	T7412	T7413	nsubj	three,had
R2138	T7413	T7397	conj	had,had
R2139	T7414	T7415	compound	FVB,N
R2140	T7415	T7413	dobj	N,had
R2141	T7416	T7415	punct	/,N
R2142	T7417	T7413	prep	as,had
R2143	T7418	T7419	det	the,allele
R2144	T7419	T7417	pobj	allele,as
R2145	T7420	T7419	compound	susceptibility,allele
R2146	T7421	T7397	punct	.,had
R2147	T7423	T7424	nsubj	Lander,suggested
R2148	T7425	T7423	cc	and,Lander
R2149	T7426	T7423	conj	Botstein,Lander
R2150	T7427	T7428	punct	[,26
R2151	T7428	T7426	parataxis	26,Botstein
R2152	T7429	T7428	punct	],26
R2153	T7430	T7431	det	a,score
R2154	T7431	T7424	dobj	score,suggested
R2155	T7432	T7431	compound	LOD,score
R2156	T7433	T7431	prep	of,score
R2157	T7434	T7435	quantmod	between,2
R2158	T7435	T7433	pobj	2,of
R2159	T7436	T7435	cc	and,2
R2160	T7437	T7435	conj	3,2
R2161	T7438	T7439	aux	to,ensure
R2162	T7439	T7424	advcl	ensure,suggested
R2163	T7440	T7441	det	an,rate
R2164	T7441	T7439	dobj	rate,ensure
R2165	T7442	T7441	amod	overall,rate
R2166	T7443	T7444	amod	false,positive
R2167	T7444	T7441	amod	positive,rate
R2168	T7445	T7441	prep	of,rate
R2169	T7446	T7447	nummod	5,%
R2170	T7447	T7445	pobj	%,of
R2171	T7448	T7424	punct	", ",suggested
R2172	T7449	T7450	dep	which,means
R2173	T7450	T7424	advcl	means,suggested
R2174	T7451	T7452	mark	that,prevent
R2175	T7452	T7450	ccomp	prevent,means
R2176	T7453	T7452	csubj	using,prevent
R2177	T7454	T7455	det	a,value
R2178	T7455	T7453	dobj	value,using
R2179	T7456	T7455	amod	lower,value
R2180	T7457	T7455	compound	threshold,value
R2181	T7458	T7452	aux	will,prevent
R2182	T7459	T7460	amod	false,negative
R2183	T7460	T7461	amod	negative,QTL
R2184	T7461	T7452	dobj	QTL,prevent
R2185	T7462	T7452	prep	at,prevent
R2186	T7463	T7464	det	the,expense
R2187	T7464	T7462	pobj	expense,at
R2188	T7465	T7464	prep	of,expense
R2189	T7466	T7465	pcomp	increasing,of
R2190	T7467	T7468	amod	false,positive
R2191	T7468	T7469	amod	positive,QTL
R2192	T7469	T7466	dobj	QTL,increasing
R2193	T7470	T7424	punct	.,suggested
R2194	T7472	T7473	advcl	Being,examined
R2195	T7474	T7472	acomp	aware,Being
R2196	T7475	T7474	prep	of,aware
R2197	T7476	T7475	pobj	this,of
R2198	T7477	T7473	punct	", ",examined
R2199	T7478	T7473	nsubj	we,examined
R2200	T7479	T7480	det	these,regions
R2201	T7480	T7473	dobj	regions,examined
R2202	T7481	T7480	amod	genomic,regions
R2203	T7482	T7483	aux	to,search
R2204	T7483	T7473	advcl	search,examined
R2205	T7484	T7485	mark	whether,linked
R2206	T7485	T7483	ccomp	linked,search
R2207	T7486	T7485	nsubjpass	they,linked
R2208	T7487	T7486	punct	", ",they
R2209	T7488	T7486	cc	or,they
R2210	T7489	T7490	poss	their,regions
R2211	T7490	T7486	conj	regions,they
R2212	T7491	T7490	amod	syntenic,regions
R2213	T7492	T7490	amod	genomic,regions
R2214	T7493	T7490	prep	on,regions
R2215	T7494	T7495	det	the,genome
R2216	T7495	T7493	pobj	genome,on
R2217	T7496	T7495	amod	human,genome
R2218	T7497	T7485	punct	", ",linked
R2219	T7498	T7485	aux	have,linked
R2220	T7499	T7485	auxpass	been,linked
R2221	T7500	T7485	advmod	previously,linked
R2222	T7501	T7485	prep	to,linked
R2223	T7502	T7501	pobj	arthritis,to
R2224	T7503	T7473	punct	.,examined
R2225	T7505	T7506	nummod	Four,QTL
R2226	T7506	T7510	nsubj	QTL,overlapped
R2227	T7507	T7508	amod	small,effect
R2228	T7508	T7506	compound	effect,QTL
R2229	T7509	T7508	punct	-,effect
R2230	T7511	T7510	prep	with,overlapped
R2231	T7512	T7513	compound	arthritis,QTL
R2232	T7513	T7511	pobj	QTL,with
R2233	T7514	T7510	prep	on,overlapped
R2234	T7515	T7516	det	the,genome
R2235	T7516	T7514	pobj	genome,on
R2236	T7517	T7516	compound	mouse,genome
R2237	T7518	T7516	acl	identified,genome
R2238	T7519	T7518	advmod	previously,identified
R2239	T7520	T7510	punct	.,overlapped
R2240	T7522	T7523	nmod	Locus,1
R2241	T7523	T7524	nsubj	1,overlap
R2242	T7525	T7523	cc	and,1
R2243	T7526	T7523	conj	2,1
R2244	T7527	T7524	prep	with,overlap
R2245	T7528	T7527	pobj	Cia13,with
R2246	T7529	T7528	cc	and,Cia13
R2247	T7530	T7528	conj	Cia14,Cia13
R2248	T7531	T7528	punct	", ",Cia13
R2249	T7532	T7533	dep	which,control
R2250	T7533	T7528	relcl	control,Cia13
R2251	T7534	T7533	dobj	severity,control
R2252	T7535	T7534	prep	of,severity
R2253	T7536	T7535	pobj	CIA,of
R2254	T7537	T7533	prep	in,control
R2255	T7538	T7539	punct	(,DBA
R2256	T7539	T7540	nmod	DBA,progeny
R2257	T7540	T7537	pobj	progeny,in
R2258	T7541	T7539	punct	/,DBA
R2259	T7542	T7539	nummod	1,DBA
R2260	T7543	T7539	punct	×,DBA
R2261	T7544	T7545	compound	BALB,C
R2262	T7545	T7539	appos	C,DBA
R2263	T7546	T7545	punct	/,C
R2264	T7547	T7539	punct	),DBA
R2265	T7548	T7540	compound	F2,progeny
R2266	T7549	T7550	punct	[,27
R2267	T7550	T7524	parataxis	27,overlap
R2268	T7551	T7550	punct	],27
R2269	T7552	T7524	punct	.,overlap
R2270	T7554	T7555	nsubj	Locus,overlaps
R2271	T7556	T7554	nummod	5,Locus
R2272	T7557	T7554	acl	located,Locus
R2273	T7558	T7557	prep	on,located
R2274	T7559	T7558	pobj	chromosome,on
R2275	T7560	T7559	nummod	10,chromosome
R2276	T7561	T7555	prep	with,overlaps
R2277	T7562	T7561	pobj	Cia8,with
R2278	T7563	T7562	punct	", ",Cia8
R2279	T7564	T7565	dep	which,identified
R2280	T7565	T7562	relcl	identified,Cia8
R2281	T7566	T7565	auxpass	was,identified
R2282	T7567	T7565	prep	in,identified
R2283	T7568	T7569	punct	(,DBA
R2284	T7569	T7570	nmod	DBA,progeny
R2285	T7570	T7567	pobj	progeny,in
R2286	T7571	T7569	punct	/,DBA
R2287	T7572	T7569	nummod	1,DBA
R2288	T7573	T7569	punct	×,DBA
R2289	T7574	T7569	appos	B10.Q,DBA
R2290	T7575	T7570	punct	),progeny
R2291	T7576	T7570	compound	F2,progeny
R2292	T7577	T7578	punct	[,28
R2293	T7578	T7555	parataxis	28,overlaps
R2294	T7579	T7578	punct	],28
R2295	T7580	T7555	punct	.,overlaps
R2296	T7582	T7583	nsubj	Locus,overlaps
R2297	T7584	T7582	nummod	6,Locus
R2298	T7585	T7583	prep	with,overlaps
R2299	T7586	T7585	pobj	Pgia7,with
R2300	T7587	T7586	punct	", ",Pgia7
R2301	T7588	T7589	dep	which,controls
R2302	T7589	T7586	relcl	controls,Pgia7
R2303	T7590	T7589	dobj	susceptibility,controls
R2304	T7591	T7590	prep	to,susceptibility
R2305	T7592	T7593	npadvmod	proteoglycan,induced
R2306	T7593	T7595	amod	induced,arthritis
R2307	T7594	T7593	punct	-,induced
R2308	T7595	T7591	pobj	arthritis,to
R2309	T7596	T7595	punct	(,arthritis
R2310	T7597	T7595	appos	PGIA,arthritis
R2311	T7598	T7589	punct	),controls
R2312	T7599	T7589	cc	and,controls
R2313	T7600	T7601	auxpass	was,identified
R2314	T7601	T7589	conj	identified,controls
R2315	T7602	T7601	prep	in,identified
R2316	T7603	T7604	punct	(,C
R2318	T7605	T7604	nmod	BALB,C
R2319	T7606	T7604	punct	/,C
R2320	T7607	T7602	pobj	progeny,in
R2321	T7608	T7604	punct	×,C
R2322	T7609	T7604	appos	DBA,C
R2323	T7610	T7609	punct	/,DBA
R2324	T7611	T7609	nummod	2,DBA
R2325	T7612	T7604	punct	),C
R2326	T7613	T7607	compound	F2,progeny
R2327	T7614	T7615	punct	[,29
R2328	T7615	T7583	parataxis	29,overlaps
R2329	T7616	T7615	punct	],29
R2330	T7617	T7583	punct	.,overlaps
R2331	T7619	T7620	det	The,regions
R2333	T7621	T7620	amod	syntenic,regions
R2334	T7622	T7620	amod	genomic,regions
R2335	T7624	T7620	prep	of,regions
R2336	T7625	T7626	nummod	five,QTL
R2337	T7626	T7624	pobj	QTL,of
R2338	T7627	T7628	amod	small,effect
R2339	T7628	T7626	compound	effect,QTL
R2340	T7629	T7628	punct	-,effect
R2341	T7630	T7626	prep	on,QTL
R2342	T7631	T7632	det	the,genome
R2343	T7632	T7630	pobj	genome,on
R2344	T7633	T7632	amod	human,genome
R2345	T7634	T7623	aux	have,reported
R2346	T7635	T7623	auxpass	been,reported
R2347	T7636	T7637	aux	to,linked
R2348	T7637	T7623	xcomp	linked,reported
R2349	T7638	T7637	auxpass	be,linked
R2350	T7639	T7637	prep	to,linked
R2351	T7640	T7639	pobj	RA,to
R2352	T7641	T7623	punct	.,reported
R2353	T7643	T7644	nsubj	These,are
R2354	T7645	T7646	amod	genomic,regions
R2355	T7646	T7644	attr	regions,are
R2356	T7647	T7646	appos	22q11,regions
R2357	T7648	T7647	cc	and,22q11
R2358	T7649	T7650	compound	12p13,q24
R2359	T7650	T7647	conj	q24,22q11
R2360	T7651	T7650	punct	-,q24
R2361	T7652	T7646	prep	on,regions
R2362	T7653	T7654	nmod	chromosome,22
R2363	T7654	T7652	pobj	22,on
R2364	T7655	T7654	cc	and,22
R2365	T7656	T7654	conj	12,22
R2366	T7657	T7658	punct	(,counterparts
R2367	T7658	T7646	parataxis	counterparts,regions
R2368	T7659	T7658	det	the,counterparts
R2369	T7660	T7658	prep	of,counterparts
R2370	T7661	T7660	pobj	locus,of
R2371	T7662	T7661	nummod	2,locus
R2372	T7663	T7658	punct	),counterparts
R2373	T7664	T7646	punct	", ",regions
R2374	T7665	T7666	compound	12p13,pter
R2375	T7666	T7646	conj	pter,regions
R2376	T7667	T7666	punct	-,pter
R2377	T7668	T7666	prep	on,pter
R2378	T7669	T7668	pobj	chromosome,on
R2379	T7670	T7669	nummod	12,chromosome
R2380	T7671	T7672	punct	(,counterpart
R2381	T7672	T7666	parataxis	counterpart,pter
R2382	T7673	T7672	det	the,counterpart
R2383	T7674	T7672	prep	of,counterpart
R2384	T7675	T7674	pobj	locus,of
R2385	T7676	T7675	nummod	3,locus
R2386	T7677	T7672	punct	),counterpart
R2387	T7678	T7666	punct	", ",pter
R2388	T7679	T7680	compound	21q22,qter
R2389	T7680	T7666	conj	qter,pter
R2390	T7681	T7680	punct	-,qter
R2391	T7682	T7680	cc	and,qter
R2392	T7683	T7680	conj	10q22,qter
R2393	T7684	T7683	punct	-,10q22
R2394	T7685	T7683	nummod	23,10q22
R2395	T7686	T7680	prep	on,qter
R2396	T7687	T7688	nmod	chromosome,21
R2397	T7688	T7686	pobj	21,on
R2398	T7689	T7688	cc	and,21
R2399	T7690	T7688	conj	10,21
R2400	T7691	T7692	punct	(,counterparts
R2401	T7692	T7680	parataxis	counterparts,qter
R2402	T7693	T7692	det	the,counterparts
R2403	T7694	T7692	prep	of,counterparts
R2404	T7695	T7694	pobj	locus,of
R2405	T7696	T7695	nummod	5,locus
R2406	T7697	T7692	punct	),counterparts
R2407	T7698	T7680	punct	", ",qter
R2408	T7699	T7680	conj	17q21,qter
R2409	T7700	T7699	punct	-,17q21
R2410	T7701	T7699	nummod	25,17q21
R2411	T7702	T7699	prep	on,17q21
R2412	T7703	T7702	pobj	chromosome,on
R2413	T7704	T7703	nummod	17,chromosome
R2414	T7705	T7706	punct	(,counterpart
R2415	T7706	T7699	parataxis	counterpart,17q21
R2416	T7707	T7706	det	the,counterpart
R2417	T7708	T7706	prep	of,counterpart
R2418	T7709	T7708	pobj	locus,of
R2419	T7710	T7709	nummod	6,locus
R2420	T7711	T7706	punct	),counterpart
R2421	T7712	T7699	cc	and,17q21
R2422	T7713	T7714	compound	3q29,qter
R2423	T7714	T7699	conj	qter,17q21
R2424	T7715	T7714	punct	-,qter
R2425	T7716	T7714	prep	on,qter
R2426	T7717	T7716	pobj	chromosome,on
R2427	T7718	T7717	nummod	3,chromosome
R2428	T7719	T7720	punct	(,counterpart
R2429	T7720	T7714	parataxis	counterpart,qter
R2430	T7721	T7720	det	the,counterpart
R2431	T7722	T7720	prep	of,counterpart
R2432	T7723	T7722	pobj	locus,of
R2433	T7724	T7723	nummod	7,locus
R2434	T7725	T7720	punct	),counterpart
R2435	T7726	T7727	punct	[,4
R2437	T7728	T7727	nummod	2,4
R2438	T7729	T7727	punct	",",4
R2439	T7730	T7727	punct	],4
R2440	T7731	T7644	punct	.,are
R2441	T8314	T8315	npadvmod	Strain,specific
R2442	T8315	T8317	amod	specific,genes
R2443	T8316	T8315	punct	-,specific
R2444	T8318	T8319	advmod	differentially,expressed
R2445	T8319	T8317	amod	expressed,genes
R2446	T8321	T8322	nsubj	We,detected
R2447	T8323	T8324	det	the,profiles
R2449	T8325	T8326	compound	gene,expression
R2450	T8326	T8324	compound	expression,profiles
R2451	T8327	T8322	advcl	using,detected
R2452	T8328	T8329	nummod	three,mice
R2453	T8329	T8327	dobj	mice,using
R2454	T8330	T8329	prep	per,mice
R2455	T8331	T8330	pobj	group,per
R2456	T8332	T8329	punct	", ",mice
R2457	T8333	T8334	dep	which,is
R2458	T8334	T8329	relcl	is,mice
R2459	T8335	T8336	det	a,number
R2460	T8336	T8334	attr	number,is
R2461	T8337	T8336	amod	small,number
R2462	T8338	T8322	punct	.,detected
R2463	T8340	T8341	advcl	Being,determined
R2464	T8342	T8340	acomp	aware,Being
R2465	T8343	T8342	prep	of,aware
R2466	T8344	T8345	det	the,importance
R2467	T8345	T8343	pobj	importance,of
R2468	T8346	T8345	prep	of,importance
R2469	T8347	T8348	compound	data,reproducibility
R2470	T8348	T8346	pobj	reproducibility,of
R2471	T8349	T8341	punct	", ",determined
R2472	T8350	T8341	nsubj	we,determined
R2473	T8351	T8352	det	the,coefficient
R2474	T8352	T8341	dobj	coefficient,determined
R2475	T8353	T8352	prep	of,coefficient
R2476	T8354	T8353	pobj	variation,of
R2477	T8355	T8352	punct	(,coefficient
R2478	T8356	T8352	appos	CV,coefficient
R2479	T8357	T8341	punct	),determined
R2480	T8358	T8359	aux	to,measure
R2481	T8359	T8341	advcl	measure,determined
R2482	T8360	T8361	compound	data,variability
R2483	T8361	T8359	dobj	variability,measure
R2484	T8362	T8341	punct	.,determined
R2485	T8364	T8365	det	The,CV
R2486	T8365	T8366	nsubjpass	CV,calculated
R2487	T8367	T8365	prep	for,CV
R2488	T8368	T8369	det	each,gene
R2489	T8369	T8367	pobj	gene,for
R2490	T8370	T8369	prep	on,gene
R2491	T8371	T8372	det	the,chip
R2492	T8372	T8370	pobj	chip,on
R2493	T8373	T8365	cc	and,CV
R2494	T8374	T8375	det	the,CV
R2495	T8375	T8365	conj	CV,CV
R2496	T8376	T8375	amod	mean,CV
R2497	T8377	T8375	prep	for,CV
R2498	T8378	T8379	det	the,probe
R2499	T8379	T8377	pobj	probe,for
R2500	T8380	T8379	amod	entire,probe
R2501	T8381	T8379	amod	set,probe
R2502	T8382	T8366	auxpass	were,calculated
R2503	T8383	T8366	punct	.,calculated
R2504	T8385	T8386	det	The,CV
R2505	T8386	T8388	nsubj	CV,ranged
R2506	T8387	T8386	amod	mean,CV
R2507	T8389	T8388	prep	between,ranged
R2508	T8390	T8391	nummod	18.4,%
R2509	T8391	T8389	pobj	%,between
R2510	T8392	T8391	cc	and,%
R2511	T8393	T8394	nummod	25.8,%
R2512	T8394	T8391	conj	%,%
R2513	T8395	T8388	prep	for,ranged
R2514	T8396	T8397	det	all,groups
R2515	T8397	T8395	pobj	groups,for
R2516	T8398	T8397	amod	experimental,groups
R2517	T8399	T8388	punct	", ",ranged
R2518	T8400	T8388	cc	and,ranged
R2519	T8401	T8402	det	this,CV
R2521	T8403	T8404	advmod	relatively,low
R2522	T8404	T8402	amod	low,CV
R2523	T8405	T8388	conj	indicated,ranged
R2524	T8406	T8407	mark	that,used
R2525	T8407	T8405	ccomp	used,indicated
R2526	T8408	T8409	det	these,data
R2527	T8409	T8407	nsubjpass	data,used
R2528	T8410	T8407	aux	could,used
R2529	T8411	T8407	auxpass	be,used
R2530	T8412	T8407	prep	for,used
R2531	T8413	T8414	amod	further,analysis
R2532	T8414	T8412	pobj	analysis,for
R2533	T8415	T8416	punct	(,Table
R2534	T8416	T8405	parataxis	Table,indicated
R2535	T8417	T8416	nummod	1,Table
R2536	T8418	T8416	punct	),Table
R2537	T8419	T8405	punct	.,indicated
R2538	T8421	T8422	aux	To,search
R2539	T8422	T8423	advcl	search,performed
R2540	T8424	T8422	prep	for,search
R2541	T8425	T8426	npadvmod	strain,specific
R2542	T8426	T8428	amod	specific,genes
R2543	T8427	T8426	punct	-,specific
R2545	T8429	T8430	advmod	differentially,expressed
R2546	T8430	T8428	amod	expressed,genes
R2547	T8431	T8423	punct	", ",performed
R2548	T8432	T8423	nsubj	we,performed
R2549	T8433	T8423	dobj	comparisons,performed
R2550	T8434	T8433	prep	of,comparisons
R2551	T8435	T8436	compound	gene,expression
R2552	T8436	T8434	pobj	expression,of
R2553	T8437	T8433	prep	between,comparisons
R2554	T8438	T8439	det	the,strains
R2555	T8439	T8437	pobj	strains,between
R2556	T8440	T8439	nmod	DBA,strains
R2557	T8441	T8440	punct	/,DBA
R2558	T8442	T8440	nummod	1,DBA
R2559	T8443	T8440	cc	and,DBA
R2560	T8444	T8445	compound	FVB,N
R2561	T8445	T8440	conj	N,DBA
R2562	T8446	T8445	punct	/,N
R2563	T8447	T8423	prep	at,performed
R2564	T8448	T8449	det	all,phases
R2565	T8449	T8447	pobj	phases,at
R2566	T8450	T8449	nummod	four,phases
R2567	T8451	T8449	prep	of,phases
R2568	T8452	T8451	pobj	CIA,of
R2569	T8453	T8449	punct	", ",phases
R2570	T8454	T8449	prep	including,phases
R2571	T8455	T8454	pobj	NC,including
R2572	T8456	T8455	punct	", ",NC
R2573	T8457	T8455	conj	PI,NC
R2574	T8458	T8457	punct	", ",PI
R2575	T8459	T8457	conj	OA,PI
R2576	T8460	T8459	cc	and,OA
R2577	T8461	T8459	conj	CA,OA
R2578	T8462	T8423	punct	.,performed
R2579	T8464	T8465	prep	For,expressed
R2580	T8466	T8467	det	the,mice
R2581	T8467	T8464	pobj	mice,For
R2582	T8468	T8467	amod	naive,mice
R2583	T8469	T8467	prep	without,mice
R2584	T8470	T8469	pobj	immunisation,without
R2585	T8471	T8465	punct	", ",expressed
R2586	T8472	T8473	nummod	361,genes
R2587	T8473	T8465	nsubjpass	genes,expressed
R2588	T8474	T8465	auxpass	were,expressed
R2589	T8475	T8465	advmod	differentially,expressed
R2590	T8476	T8465	prep	between,expressed
R2591	T8477	T8478	det	the,strains
R2592	T8478	T8476	pobj	strains,between
R2593	T8479	T8478	nummod	two,strains
R2594	T8480	T8465	punct	.,expressed
R2595	T8482	T8483	prep	On,expressed
R2596	T8484	T8482	pobj	day,On
R2597	T8485	T8484	nummod	10,day
R2598	T8486	T8484	prep	after,day
R2599	T8487	T8486	pobj	immunisation,after
R2600	T8488	T8484	punct	", ",day
R2601	T8489	T8490	advmod	when,show
R2602	T8490	T8484	relcl	show,day
R2603	T8491	T8492	det	both,strains
R2604	T8492	T8490	nsubj	strains,show
R2605	T8493	T8490	aux	did,show
R2606	T8494	T8490	neg	not,show
R2607	T8495	T8496	det	any,sign
R2608	T8496	T8490	dobj	sign,show
R2609	T8497	T8496	prep	of,sign
R2610	T8498	T8499	det	the,disease
R2611	T8499	T8497	pobj	disease,of
R2612	T8500	T8483	punct	", ",expressed
R2613	T8501	T8502	nummod	141,genes
R2614	T8502	T8483	nsubjpass	genes,expressed
R2615	T8503	T8483	auxpass	were,expressed
R2616	T8504	T8483	advmod	differentially,expressed
R2617	T8505	T8483	punct	.,expressed
R2618	T8507	T8508	mark	After,developed
R2619	T8508	T8513	advcl	developed,identified
R2620	T8509	T8510	nmod	DBA,mice
R2621	T8510	T8508	nsubj	mice,developed
R2622	T8511	T8509	punct	/,DBA
R2623	T8512	T8509	nummod	1,DBA
R2624	T8514	T8508	dobj	CIA,developed
R2625	T8515	T8513	punct	", ",identified
R2626	T8516	T8517	nummod	184,genes
R2627	T8517	T8513	nsubjpass	genes,identified
R2628	T8518	T8516	cc	and,184
R2629	T8519	T8516	conj	85,184
R2630	T8520	T8521	advmod	differentially,expressed
R2631	T8521	T8517	amod	expressed,genes
R2632	T8522	T8513	auxpass	were,identified
R2633	T8523	T8513	prep	between,identified
R2634	T8524	T8525	det	these,strains
R2635	T8525	T8523	pobj	strains,between
R2636	T8526	T8525	nummod	two,strains
R2637	T8527	T8513	prep	at,identified
R2638	T8528	T8529	det	the,phases
R2639	T8529	T8527	pobj	phases,at
R2640	T8530	T8529	nmod	onset,phases
R2641	T8531	T8530	cc	and,onset
R2642	T8532	T8530	conj	chronic,onset
R2643	T8533	T8513	punct	", ",identified
R2644	T8534	T8513	advmod	respectively,identified
R2645	T8535	T8513	punct	.,identified
R2646	T8537	T8538	advmod	When,merged
R2647	T8538	T8551	advcl	merged,identified
R2648	T8539	T8540	det	the,lists
R2649	T8540	T8538	nsubjpass	lists,merged
R2650	T8541	T8540	prep	of,lists
R2651	T8542	T8543	det	the,genes
R2652	T8543	T8541	pobj	genes,of
R2653	T8544	T8545	advmod	differentially,expressed
R2654	T8545	T8543	amod	expressed,genes
R2655	T8546	T8540	prep	at,lists
R2656	T8547	T8548	det	the,phases
R2657	T8548	T8546	pobj	phases,at
R2658	T8549	T8548	nummod	four,phases
R2659	T8550	T8538	auxpass	were,merged
R2660	T8552	T8538	cc	and,merged
R2661	T8553	T8554	amod	overlapping,genes
R2662	T8554	T8555	nsubjpass	genes,excluded
R2663	T8555	T8538	conj	excluded,merged
R2664	T8556	T8555	auxpass	were,excluded
R2665	T8557	T8551	punct	", ",identified
R2666	T8558	T8559	nummod	509,genes
R2667	T8559	T8551	nsubjpass	genes,identified
R2668	T8560	T8551	auxpass	were,identified
R2669	T8561	T8562	punct	(,file
R2670	T8562	T8551	parataxis	file,identified
R2671	T8563	T8562	amod	Additional,file
R2672	T8564	T8562	nummod	1,file
R2673	T8565	T8562	punct	),file
R2674	T8566	T8551	punct	.,identified
R2675	T8568	T8569	compound	Twenty,one
R2676	T8569	T8571	nummod	one,genes
R2677	T8570	T8569	punct	-,one
R2678	T8571	T8572	nsubj	genes,showed
R2679	T8573	T8572	advmod	consistently,showed
R2680	T8574	T8575	amod	differential,expression
R2681	T8575	T8572	dobj	expression,showed
R2682	T8576	T8572	prep	between,showed
R2683	T8577	T8578	det	the,strains
R2684	T8578	T8576	pobj	strains,between
R2685	T8579	T8578	nummod	two,strains
R2686	T8580	T8572	prep	at,showed
R2687	T8581	T8582	det	all,phases
R2688	T8582	T8580	pobj	phases,at
R2689	T8583	T8572	punct	.,showed
R2690	T8585	T8586	prep	Besides,expressed
R2691	T8587	T8588	det	these,genes
R2692	T8588	T8585	pobj	genes,Besides
R2693	T8589	T8588	nummod	21,genes
R2694	T8590	T8586	punct	", ",expressed
R2695	T8591	T8592	advmod	only,genes
R2697	T8593	T8592	nummod	3,genes
R2698	T8594	T8592	amod	additional,genes
R2699	T8595	T8586	auxpass	were,expressed
R2700	T8596	T8597	npadvmod	strain,specific
R2701	T8597	T8586	advmod	specific,expressed
R2702	T8598	T8597	punct	-,specific
R2703	T8599	T8586	advmod	differentially,expressed
R2704	T8600	T8586	prep	during,expressed
R2705	T8601	T8602	det	the,phases
R2706	T8602	T8600	pobj	phases,during
R2707	T8603	T8602	nummod	3,phases
R2708	T8604	T8602	prep	after,phases
R2709	T8605	T8606	compound	CIA,induction
R2710	T8606	T8604	pobj	induction,after
R2711	T8607	T8608	punct	(,Figure
R2712	T8608	T8586	parataxis	Figure,expressed
R2713	T8609	T8608	dep	PI,Figure
R2714	T8610	T8609	punct	", ",PI
R2715	T8611	T8609	conj	OA,PI
R2716	T8612	T8611	cc	and,OA
R2717	T8613	T8611	conj	CA,OA
R2718	T8614	T8608	punct	;,Figure
R2719	T8615	T8608	nummod	1,Figure
R2720	T8616	T8608	punct	),Figure
R2721	T8617	T8586	punct	.,expressed
R2724	T9552	T9553	npadvmod	Disease,specific
R2725	T9553	T9555	amod	specific,genes
R2726	T9554	T9553	punct	-,specific
R2727	T9556	T9557	advmod	differentially,expressed
R2728	T9557	T9555	amod	expressed,genes
R2729	T9559	T9560	aux	To,identify
R2730	T9560	T9561	advcl	identify,detected
R2731	T9562	T9563	det	the,genes
R2732	T9563	T9560	dobj	genes,identify
R2733	T9564	T9565	npadvmod	disease,specific
R2734	T9565	T9563	amod	specific,genes
R2735	T9566	T9565	punct	-,specific
R2736	T9567	T9568	advmod	differentially,expressed
R2737	T9568	T9563	amod	expressed,genes
R2738	T9569	T9560	prep	in,identify
R2739	T9570	T9569	pobj	CIA,in
R2740	T9571	T9561	punct	", ",detected
R2741	T9572	T9561	nsubj	we,detected
R2742	T9573	T9574	det	the,genes
R2743	T9574	T9561	dobj	genes,detected
R2744	T9575	T9576	dep	that,expressed
R2745	T9576	T9574	relcl	expressed,genes
R2746	T9577	T9576	auxpass	were,expressed
R2747	T9578	T9576	advmod	differentially,expressed
R2748	T9579	T9576	prep	in,expressed
R2749	T9580	T9579	pobj	LNs,in
R2750	T9581	T9576	prep	during,expressed
R2751	T9582	T9581	pobj	CIA,during
R2752	T9583	T9576	prep	in,expressed
R2753	T9584	T9585	det	the,strain
R2754	T9585	T9583	pobj	strain,in
R2755	T9586	T9585	amod	susceptible,strain
R2756	T9587	T9561	punct	.,detected
R2757	T9589	T9590	nummod	Three,conditions
R2758	T9590	T9592	nsubjpass	conditions,compared
R2759	T9591	T9590	amod	experimental,conditions
R2760	T9593	T9590	punct	", ",conditions
R2761	T9594	T9590	appos	PI,conditions
R2762	T9595	T9594	punct	", ",PI
R2763	T9596	T9594	conj	OA,PI
R2764	T9597	T9596	cc	and,OA
R2765	T9598	T9596	conj	CA,OA
R2766	T9599	T9592	punct	", ",compared
R2767	T9600	T9592	auxpass	were,compared
R2768	T9601	T9592	prep	with,compared
R2769	T9602	T9603	det	the,group
R2770	T9603	T9601	pobj	group,with
R2771	T9604	T9603	compound	NC,group
R2772	T9605	T9592	punct	.,compared
R2773	T9607	T9608	prep	On,upregulated
R2774	T9609	T9607	pobj	day,On
R2775	T9610	T9609	nummod	10,day
R2776	T9611	T9609	prep	after,day
R2777	T9612	T9611	pobj	immunisation,after
R2778	T9613	T9608	punct	", ",upregulated
R2779	T9614	T9615	nummod	102,genes
R2780	T9615	T9616	nsubjpass	genes,expressed
R2781	T9616	T9608	ccomp	expressed,upregulated
R2782	T9617	T9616	auxpass	were,expressed
R2783	T9618	T9616	advmod	differentially,expressed
R2784	T9619	T9608	punct	–,upregulated
R2785	T9620	T9608	nsubjpass	most,upregulated
R2786	T9621	T9620	prep	of,most
R2787	T9622	T9621	pobj	them,of
R2788	T9623	T9608	auxpass	were,upregulated
R2789	T9624	T9625	punct	(,102
R2790	T9625	T9608	parataxis	102,upregulated
R2791	T9626	T9625	quantmod	78,102
R2792	T9627	T9625	quantmod	out,102
R2793	T9628	T9625	quantmod	of,102
R2794	T9629	T9625	punct	),102
R2795	T9630	T9608	punct	–,upregulated
R2796	T9631	T9632	mark	while,expressed
R2797	T9632	T9608	advcl	expressed,upregulated
R2798	T9633	T9632	prep	at,expressed
R2799	T9634	T9635	det	the,phase
R2800	T9635	T9633	pobj	phase,at
R2801	T9636	T9635	compound	onset,phase
R2802	T9637	T9635	prep	of,phase
R2803	T9638	T9639	det	the,disease
R2804	T9639	T9637	pobj	disease,of
R2805	T9640	T9632	punct	", ",expressed
R2806	T9641	T9642	advmod	only,genes
R2807	T9642	T9632	nsubjpass	genes,expressed
R2808	T9643	T9642	nummod	26,genes
R2809	T9644	T9632	auxpass	were,expressed
R2810	T9645	T9632	advmod	differentially,expressed
R2811	T9646	T9608	punct	.,upregulated
R2812	T9648	T9649	prep	At,identified
R2813	T9650	T9651	det	the,phase
R2814	T9651	T9648	pobj	phase,At
R2815	T9652	T9651	amod	chronic,phase
R2816	T9653	T9651	prep	of,phase
R2817	T9654	T9655	det	the,disease
R2818	T9655	T9653	pobj	disease,of
R2819	T9656	T9649	punct	", ",identified
R2820	T9657	T9658	nummod	184,genes
R2821	T9658	T9649	nsubjpass	genes,identified
R2822	T9659	T9660	advmod	differentially,expressed
R2823	T9660	T9658	amod	expressed,genes
R2824	T9661	T9649	auxpass	were,identified
R2825	T9662	T9649	punct	", ",identified
R2826	T9663	T9649	prep	with,identified
R2827	T9664	T9665	nummod	156,genes
R2828	T9665	T9663	pobj	genes,with
R2829	T9666	T9665	amod	downregulated,genes
R2830	T9667	T9649	punct	.,identified
R2831	T9669	T9670	advmod	Only,gene
R2832	T9670	T9672	nsubjpass	gene,expressed
R2833	T9671	T9670	nummod	one,gene
R2834	T9673	T9672	auxpass	was,expressed
R2835	T9674	T9672	advmod	differentially,expressed
R2836	T9675	T9672	prep	at,expressed
R2837	T9676	T9677	det	all,phases
R2838	T9677	T9675	pobj	phases,at
R2839	T9678	T9677	nummod	three,phases
R2840	T9679	T9677	prep	of,phases
R2841	T9680	T9679	pobj	CIA,of
R2842	T9681	T9672	punct	.,expressed
R2843	T9683	T9684	prep	Besides,shared
R2844	T9685	T9686	det	this,gene
R2845	T9686	T9683	pobj	gene,Besides
R2846	T9687	T9684	punct	", ",shared
R2847	T9688	T9689	nummod	five,genes
R2848	T9689	T9684	nsubjpass	genes,shared
R2849	T9690	T9688	punct	", ",five
R2850	T9691	T9688	conj	one,five
R2851	T9692	T9691	cc	and,one
R2852	T9693	T9691	conj	six,one
R2853	T9694	T9695	advmod	differentially,expressed
R2854	T9695	T9689	amod	expressed,genes
R2855	T9696	T9684	auxpass	were,shared
R2856	T9697	T9684	agent	by,shared
R2857	T9698	T9697	pobj	PI,by
R2858	T9699	T9698	prep	with,PI
R2859	T9700	T9699	pobj	OA,with
R2860	T9701	T9698	punct	", ",PI
R2861	T9702	T9698	conj	PI,PI
R2862	T9703	T9702	prep	with,PI
R2863	T9704	T9703	pobj	CA,with
R2864	T9705	T9702	cc	and,PI
R2865	T9706	T9702	conj	OA,PI
R2866	T9707	T9706	prep	with,OA
R2867	T9708	T9707	pobj	CA,with
R2868	T9709	T9684	punct	", ",shared
R2869	T9710	T9684	advmod	respectively,shared
R2870	T9711	T9712	punct	(,2a
R2871	T9712	T9684	parataxis	2a,shared
R2872	T9713	T9712	compound	Figure,2a
R2873	T9714	T9712	punct	),2a
R2874	T9715	T9684	punct	.,shared
R2875	T9717	T9718	advcl	Taken,regulated
R2876	T9719	T9717	advmod	together,Taken
R2877	T9720	T9718	punct	", ",regulated
R2878	T9721	T9722	nummod	310,genes
R2879	T9722	T9718	nsubjpass	genes,regulated
R2880	T9723	T9724	npadvmod	disease,specific
R2881	T9724	T9722	amod	specific,genes
R2882	T9725	T9724	punct	-,specific
R2883	T9726	T9727	advmod	differentially,expressed
R2884	T9727	T9722	amod	expressed,genes
R2885	T9728	T9718	auxpass	were,regulated
R2886	T9729	T9718	advmod	differentially,regulated
R2887	T9730	T9718	prep	during,regulated
R2888	T9731	T9730	pobj	CIA,during
R2889	T9732	T9718	prep	in,regulated
R2890	T9733	T9734	nmod	DBA,mice
R2891	T9734	T9732	pobj	mice,in
R2892	T9735	T9733	punct	/,DBA
R2893	T9736	T9733	nummod	1,DBA
R2894	T9737	T9738	punct	(,file
R2895	T9738	T9718	parataxis	file,regulated
R2896	T9739	T9738	amod	Additional,file
R2897	T9740	T9738	nummod	2,file
R2898	T9741	T9738	punct	),file
R2899	T9742	T9718	punct	.,regulated
R2900	T9744	T9745	aux	To,characterise
R2901	T9745	T9747	advcl	characterise,performed
R2902	T9746	T9745	advmod	further,characterise
R2903	T9748	T9749	det	the,pattern
R2904	T9749	T9745	dobj	pattern,characterise
R2905	T9750	T9751	compound	gene,expression
R2906	T9751	T9749	compound	expression,pattern
R2907	T9752	T9745	prep	during,characterise
R2908	T9753	T9752	pobj	CIA,during
R2909	T9754	T9747	punct	", ",performed
R2910	T9755	T9747	nsubj	we,performed
R2911	T9756	T9757	amod	hierarchical,analysis
R2912	T9757	T9747	dobj	analysis,performed
R2913	T9758	T9757	compound	cluster,analysis
R2914	T9759	T9747	prep	for,performed
R2915	T9760	T9761	det	these,genes
R2916	T9761	T9759	pobj	genes,for
R2917	T9762	T9761	nummod	310,genes
R2918	T9763	T9747	punct	.,performed
R2919	T9765	T9766	nummod	Six,clusters
R2920	T9766	T9768	nsubjpass	clusters,identified
R2921	T9767	T9766	compound	gene,clusters
R2922	T9769	T9768	auxpass	were,identified
R2923	T9770	T9771	punct	(,I
R2924	T9771	T9768	parataxis	I,identified
R2925	T9772	T9771	nmod	clusters,I
R2926	T9773	T9771	prep	to,I
R2927	T9774	T9773	pobj	VI,to
R2928	T9775	T9771	punct	", ",I
R2929	T9776	T9777	compound	Figure,2b
R2930	T9777	T9771	appos	2b,I
R2931	T9778	T9771	punct	),I
R2932	T9779	T9768	punct	", ",identified
R2933	T9780	T9768	npadvmod	each,identified
R2934	T9781	T9780	prep	with,each
R2935	T9782	T9783	det	a,pattern
R2936	T9783	T9781	pobj	pattern,with
R2937	T9784	T9783	amod	distinct,pattern
R2938	T9785	T9786	compound	gene,expression
R2939	T9786	T9783	compound	expression,pattern
R2940	T9787	T9768	prep	during,identified
R2941	T9788	T9787	pobj	CIA,during
R2942	T9789	T9768	punct	.,identified
R2943	T9791	T9792	nsubj	Cluster,contains
R2944	T9793	T9791	nummod	I,Cluster
R2945	T9794	T9795	nummod	16,genes
R2946	T9795	T9792	dobj	genes,contains
R2947	T9796	T9795	punct	", ",genes
R2948	T9797	T9795	acl	representing,genes
R2949	T9798	T9797	dobj	genes,representing
R2950	T9799	T9800	dep	that,upregulated
R2951	T9800	T9798	relcl	upregulated,genes
R2952	T9801	T9800	auxpass	were,upregulated
R2953	T9802	T9800	prep	after,upregulated
R2954	T9803	T9802	pobj	induction,after
R2955	T9804	T9803	prep	of,induction
R2956	T9805	T9804	pobj	CIA,of
R2957	T9806	T9792	punct	.,contains
R2958	T9808	T9809	det	The,expression
R2959	T9809	T9810	nsubj	expression,reached
R2960	T9811	T9809	prep	of,expression
R2961	T9812	T9813	det	these,genes
R2962	T9813	T9811	pobj	genes,of
R2963	T9814	T9815	det	a,peak
R2964	T9815	T9810	dobj	peak,reached
R2965	T9816	T9810	prep	at,reached
R2966	T9817	T9818	det	the,phase
R2967	T9818	T9816	pobj	phase,at
R2968	T9819	T9818	compound	onset,phase
R2969	T9820	T9818	prep	of,phase
R2970	T9821	T9822	det	the,disease
R2971	T9822	T9820	pobj	disease,of
R2972	T9823	T9810	cc	and,reached
R2973	T9824	T9825	amod	functional,results
R2974	T9825	T9827	nsubj	results,revealed
R2975	T9826	T9825	compound	clustering,results
R2976	T9827	T9810	conj	revealed,reached
R2977	T9828	T9829	mark	that,related
R2978	T9829	T9827	ccomp	related,revealed
R2979	T9830	T9829	nsubjpass	they,related
R2980	T9831	T9829	auxpass	are,related
R2981	T9832	T9829	prep	to,related
R2982	T9833	T9834	det	the,response
R2983	T9834	T9832	pobj	response,to
R2984	T9835	T9834	amod	immune,response
R2985	T9836	T9827	punct	.,revealed
R2986	T9838	T9839	nsubj	Cluster,contains
R2987	T9840	T9838	nummod	II,Cluster
R2988	T9841	T9842	nummod	12,genes
R2989	T9842	T9839	dobj	genes,contains
R2990	T9843	T9844	poss	whose,expression
R2991	T9844	T9845	dep	expression,upregulated
R2992	T9845	T9842	relcl	upregulated,genes
R2993	T9846	T9845	auxpass	was,upregulated
R2994	T9847	T9845	advmod	gradually,upregulated
R2995	T9848	T9845	cc	and,upregulated
R2996	T9849	T9845	conj	reached,upregulated
R2997	T9850	T9851	det	a,peak
R2998	T9851	T9849	dobj	peak,reached
R2999	T9852	T9849	prep	at,reached
R3000	T9853	T9854	det	the,phase
R3001	T9854	T9852	pobj	phase,at
R3002	T9855	T9854	amod	chronic,phase
R3003	T9856	T9854	prep	of,phase
R3004	T9857	T9856	pobj	CIA,of
R3005	T9858	T9839	punct	.,contains
R3006	T9860	T9861	det	These,genes
R3007	T9861	T9862	nsubjpass	genes,related
R3008	T9863	T9862	auxpass	are,related
R3009	T9864	T9862	advmod	mainly,related
R3010	T9865	T9862	prep	to,related
R3011	T9866	T9867	det	the,response
R3012	T9867	T9865	pobj	response,to
R3013	T9868	T9867	amod	immune,response
R3014	T9869	T9867	punct	", ",response
R3015	T9870	T9871	compound	organelle,membrane
R3016	T9871	T9867	conj	membrane,response
R3017	T9872	T9871	cc	and,membrane
R3018	T9873	T9874	amod	extracellular,region
R3019	T9874	T9871	conj	region,membrane
R3020	T9875	T9874	cc	and,region
R3021	T9876	T9874	conj	space,region
R3022	T9877	T9862	punct	.,related
R3023	T9879	T9880	nsubj	Cluster,contains
R3024	T9881	T9879	nummod	III,Cluster
R3025	T9882	T9883	nummod	78,genes
R3026	T9883	T9880	dobj	genes,contains
R3027	T9884	T9885	dep	that,upregulated
R3028	T9885	T9883	relcl	upregulated,genes
R3029	T9886	T9885	auxpass	were,upregulated
R3030	T9887	T9885	advmod	only,upregulated
R3031	T9888	T9885	prep	at,upregulated
R3032	T9889	T9890	det	the,phase
R3033	T9890	T9888	pobj	phase,at
R3034	T9891	T9890	compound	PI,phase
R3035	T9892	T9880	punct	.,contains
R3036	T9894	T9895	det	These,genes
R3037	T9895	T9896	nsubjpass	genes,related
R3038	T9897	T9896	auxpass	are,related
R3039	T9898	T9896	prep	to,related
R3040	T9899	T9900	det	the,junction
R3041	T9900	T9898	pobj	junction,to
R3042	T9901	T9900	amod	intercellular,junction
R3043	T9902	T9896	punct	.,related
R3044	T9904	T9905	amod	More,half
R3045	T9905	T9907	nsubj	half,belong
R3046	T9906	T9905	quantmod	than,half
R3047	T9908	T9905	prep	of,half
R3048	T9909	T9910	det	the,genes
R3049	T9910	T9908	pobj	genes,of
R3050	T9911	T9912	punct	(,310
R3051	T9912	T9905	parataxis	310,half
R3052	T9913	T9912	quantmod	156,310
R3053	T9914	T9912	quantmod	of,310
R3054	T9915	T9912	punct	),310
R3055	T9916	T9907	prep	to,belong
R3056	T9917	T9916	pobj	cluster,to
R3057	T9918	T9917	nummod	IV,cluster
R3058	T9919	T9907	cc	and,belong
R3059	T9920	T9907	conj	represent,belong
R3060	T9921	T9920	dobj	genes,represent
R3061	T9922	T9923	advmod	specifically,downregultaed
R3062	T9923	T9921	acl	downregultaed,genes
R3063	T9924	T9923	prep	at,downregultaed
R3064	T9925	T9926	det	the,phase
R3065	T9926	T9924	pobj	phase,at
R3066	T9927	T9926	amod	chronic,phase
R3067	T9928	T9907	punct	.,belong
R3068	T9930	T9931	det	These,genes
R3069	T9931	T9932	nsubjpass	genes,related
R3070	T9933	T9932	auxpass	are,related
R3071	T9934	T9932	advmod	functionally,related
R3072	T9935	T9932	prep	to,related
R3073	T9936	T9937	compound	lymphocyte,proliferation
R3074	T9937	T9935	pobj	proliferation,to
R3075	T9938	T9937	punct	", ",proliferation
R3076	T9939	T9940	compound	T,cell
R3077	T9940	T9941	compound	cell,activation
R3078	T9941	T9937	appos	activation,proliferation
R3079	T9942	T9937	punct	", ",proliferation
R3080	T9943	T9944	compound	protein,binding
R3081	T9944	T9937	appos	binding,proliferation
R3082	T9945	T9946	advmod	as,as
R3083	T9946	T9937	cc	as,proliferation
R3084	T9947	T9946	advmod	well,as
R3085	T9948	T9949	det	the,pathway
R3086	T9949	T9937	conj	pathway,proliferation
R3087	T9950	T9949	compound	notch,pathway
R3088	T9951	T9949	compound	signal,pathway
R3089	T9952	T9932	punct	.,related
R3090	T9954	T9955	nsubj	Cluster,contains
R3091	T9956	T9954	nummod	V,Cluster
R3092	T9957	T9958	nummod	eight,genes
R3093	T9958	T9955	dobj	genes,contains
R3094	T9959	T9958	acl	downregulated,genes
R3095	T9960	T9959	prep	at,downregulated
R3096	T9961	T9962	det	the,phase
R3097	T9962	T9960	pobj	phase,at
R3098	T9963	T9962	compound	PI,phase
R3099	T9964	T9955	punct	.,contains
R3100	T9966	T9967	nsubj	Cluster,contains
R3101	T9968	T9966	nummod	VI,Cluster
R3102	T9969	T9970	nummod	18,genes
R3103	T9970	T9967	dobj	genes,contains
R3104	T9971	T9970	acl	downregulated,genes
R3105	T9972	T9971	prep	at,downregulated
R3106	T9973	T9974	det	the,phase
R3107	T9974	T9972	pobj	phase,at
R3108	T9975	T9974	compound	OA,phase
R3109	T9976	T9967	punct	.,contains
R3110	T9978	T9979	det	The,classification
R3111	T9979	T9982	nsubj	classification,showed
R3112	T9980	T9979	compound	GO,classification
R3113	T9981	T9979	compound	term,classification
R3114	T9983	T9984	det	no,cluster
R3115	T9984	T9982	dobj	cluster,showed
R3116	T9985	T9984	amod	functional,cluster
R3117	T9986	T9987	dep	that,enriched
R3118	T9987	T9984	relcl	enriched,cluster
R3119	T9988	T9987	auxpass	was,enriched
R3120	T9989	T9987	advmod	significantly,enriched
R3121	T9990	T9987	prep	in,enriched
R3122	T9991	T9992	det	these,clusters
R3123	T9992	T9990	pobj	clusters,in
R3124	T9993	T9992	nummod	two,clusters
R3125	T9994	T9992	compound	gene,clusters
R3126	T9995	T9982	punct	.,showed
R3127	T10781	T10782	compound	Candidate,genes
R3128	T10783	T10782	prep	for,genes
R3129	T10784	T10785	det	the,QTL
R3130	T10785	T10783	pobj	QTL,for
R3131	T10786	T10787	amod	small,effect
R3132	T10787	T10785	compound	effect,QTL
R3133	T10788	T10787	punct	-,effect
R3134	T10789	T10785	prep	of,QTL
R3135	T10790	T10789	pobj	CIA,of
R3136	T10792	T10793	aux	To,identify
R3137	T10793	T10794	advcl	identify,compared
R3138	T10794	T10807	ccomp	compared,shared
R3139	T10795	T10796	compound	candidate,genes
R3140	T10796	T10793	dobj	genes,identify
R3141	T10797	T10796	compound	susceptibility,genes
R3142	T10798	T10796	prep	for,genes
R3143	T10799	T10800	det	the,QTL
R3144	T10800	T10798	pobj	QTL,for
R3145	T10801	T10800	nmod	CIA,QTL
R3146	T10802	T10803	amod	small,effect
R3147	T10803	T10800	compound	effect,QTL
R3148	T10804	T10803	punct	-,effect
R3149	T10805	T10794	punct	", ",compared
R3150	T10806	T10794	nsubj	we,compared
R3151	T10808	T10809	det	the,list
R3152	T10809	T10794	dobj	list,compared
R3153	T10810	T10809	prep	of,list
R3154	T10811	T10812	npadvmod	strain,specific
R3155	T10812	T10814	amod	specific,genes
R3156	T10813	T10812	punct	-,specific
R3157	T10814	T10810	pobj	genes,of
R3158	T10815	T10816	advmod	differentially,expressed
R3159	T10816	T10814	amod	expressed,genes
R3160	T10817	T10794	prep	with,compared
R3161	T10818	T10819	det	the,list
R3162	T10819	T10817	pobj	list,with
R3163	T10820	T10819	prep	of,list
R3164	T10821	T10822	npadvmod	disease,specific
R3165	T10822	T10824	amod	specific,genes
R3166	T10823	T10822	punct	-,specific
R3167	T10824	T10820	pobj	genes,of
R3168	T10825	T10826	advmod	differentially,expressed
R3169	T10826	T10824	amod	expressed,genes
R3170	T10827	T10807	punct	;,shared
R3171	T10828	T10829	nummod	117,genes
R3172	T10829	T10807	nsubjpass	genes,shared
R3173	T10830	T10807	auxpass	were,shared
R3174	T10831	T10807	agent	by,shared
R3175	T10832	T10833	det	both,lists
R3176	T10833	T10831	pobj	lists,by
R3177	T10834	T10835	punct	(,file
R3178	T10835	T10807	parataxis	file,shared
R3179	T10836	T10835	amod	Additional,file
R3180	T10837	T10835	nummod	3,file
R3181	T10838	T10835	punct	),file
R3182	T10839	T10807	punct	.,shared
R3183	T10841	T10842	nsubj	Figure,visualises
R3184	T10843	T10841	nummod	3,Figure
R3185	T10844	T10842	dobj	positions,visualises
R3186	T10845	T10844	prep	of,positions
R3187	T10846	T10847	det	the,genes
R3188	T10847	T10845	pobj	genes,of
R3189	T10848	T10847	nummod	117,genes
R3190	T10849	T10847	acl	retrieved,genes
R3191	T10850	T10849	prep	from,retrieved
R3192	T10851	T10850	pobj	Ensembl,from
R3193	T10852	T10853	punct	[,30
R3194	T10853	T10849	parataxis	30,retrieved
R3195	T10854	T10853	punct	],30
R3196	T10855	T10842	prep	in,visualises
R3197	T10856	T10855	pobj	relation,in
R3198	T10857	T10856	prep	to,relation
R3199	T10858	T10859	det	the,QTL
R3201	T10860	T10859	nummod	8,QTL
R3202	T10861	T10862	amod	small,effect
R3203	T10862	T10859	compound	effect,QTL
R3204	T10863	T10862	punct	-,effect
R3205	T10864	T10842	punct	.,visualises
R3206	T10866	T10867	det	The,loci
R3207	T10867	T10869	nsubjpass	loci,located
R3208	T10868	T10867	nummod	eight,loci
R3209	T10870	T10869	auxpass	were,located
R3210	T10871	T10869	prep	on,located
R3211	T10872	T10873	nummod	7,chromosomes
R3212	T10873	T10871	pobj	chromosomes,on
R3213	T10874	T10873	punct	", ",chromosomes
R3214	T10875	T10873	appos	5,chromosomes
R3215	T10876	T10875	punct	", ",5
R3216	T10877	T10875	conj	6,5
R3217	T10878	T10877	punct	", ",6
R3218	T10879	T10877	conj	7,6
R3219	T10880	T10879	punct	", ",7
R3220	T10881	T10879	conj	10,7
R3221	T10882	T10881	punct	", ",10
R3222	T10883	T10881	conj	11,10
R3223	T10884	T10883	punct	", ",11
R3224	T10885	T10883	conj	16,11
R3225	T10886	T10885	cc	and,16
R3226	T10887	T10885	conj	17,16
R3227	T10888	T10869	punct	.,located
R3228	T10890	T10891	mark	Since,are
R3229	T10891	T10900	advcl	are,used
R3230	T10892	T10893	det	the,intervals
R3231	T10893	T10891	nsubj	intervals,are
R3232	T10894	T10893	compound	confidence,intervals
R3233	T10895	T10893	prep	of,intervals
R3234	T10896	T10895	pobj	QTL,of
R3235	T10897	T10893	prep	in,intervals
R3236	T10898	T10899	compound	F2,progeny
R3237	T10899	T10897	pobj	progeny,in
R3238	T10901	T10902	quantmod	around,20
R3239	T10902	T10903	nummod	20,cM
R3240	T10903	T10891	attr	cM,are
R3241	T10904	T10905	punct	[,26
R3242	T10905	T10891	parataxis	26,are
R3243	T10906	T10905	punct	],26
R3244	T10907	T10900	punct	", ",used
R3245	T10908	T10900	nsubj	we,used
R3246	T10909	T10910	nummod	40,Mb
R3247	T10910	T10900	dobj	Mb,used
R3248	T10911	T10900	prep	as,used
R3249	T10912	T10913	det	the,intervals
R3250	T10913	T10911	pobj	intervals,as
R3251	T10914	T10913	compound	confidence,intervals
R3252	T10915	T10913	prep	for,intervals
R3253	T10916	T10917	det	all,loci
R3254	T10917	T10915	pobj	loci,for
R3255	T10918	T10900	punct	.,used
R3256	T10920	T10921	compound	Twenty,one
R3257	T10921	T10923	nummod	one,genes
R3258	T10922	T10921	punct	-,one
R3259	T10923	T10924	nsubjpass	genes,located
R3260	T10925	T10924	auxpass	were,located
R3261	T10926	T10924	prep	in,located
R3262	T10927	T10928	det	the,intervals
R3263	T10928	T10926	pobj	intervals,in
R3264	T10929	T10928	compound	confidence,intervals
R3265	T10930	T10928	prep	of,intervals
R3266	T10931	T10932	quantmod	six,eight
R3267	T10932	T10935	nummod	eight,QTL
R3268	T10933	T10932	quantmod	of,eight
R3269	T10934	T10932	quantmod	the,eight
R3270	T10935	T10930	pobj	QTL,of
R3271	T10936	T10924	punct	.,located
R3272	T10938	T10939	nsubj	We,located
R3273	T10940	T10941	nummod	5,genes
R3274	T10941	T10939	dobj	genes,located
R3275	T10942	T10940	punct	", ",5
R3276	T10943	T10940	conj	4,5
R3277	T10944	T10943	punct	", ",4
R3278	T10945	T10943	conj	2,4
R3279	T10946	T10945	punct	", ",2
R3280	T10947	T10945	conj	1,2
R3281	T10948	T10947	punct	", ",1
R3282	T10949	T10947	conj	3,1
R3283	T10950	T10949	cc	and,3
R3284	T10951	T10949	conj	6,3
R3285	T10952	T10941	amod	potential,genes
R3286	T10953	T10941	compound	candidate,genes
R3287	T10954	T10939	prep	within,located
R3288	T10955	T10956	det	the,intervals
R3289	T10956	T10954	pobj	intervals,within
R3290	T10957	T10956	compound	confidence,intervals
R3291	T10958	T10956	prep	of,intervals
R3292	T10959	T10960	nmod	loci,1
R3293	T10960	T10958	pobj	1,of
R3294	T10961	T10960	punct	", ",1
R3295	T10962	T10960	conj	2,1
R3296	T10963	T10962	punct	", ",2
R3297	T10964	T10962	conj	3,2
R3298	T10965	T10964	punct	", ",3
R3299	T10966	T10964	conj	5,3
R3300	T10967	T10966	punct	", ",5
R3301	T10968	T10966	conj	6,5
R3302	T10969	T10968	cc	and,6
R3303	T10970	T10968	conj	8,6
R3304	T10971	T10939	punct	", ",located
R3305	T10972	T10939	advmod	respectively,located
R3306	T10973	T10939	punct	", ",located
R3307	T10974	T10975	mark	while,identified
R3309	T10976	T10977	det	no,gene
R3310	T10977	T10975	nsubjpass	gene,identified
R3311	T10978	T10977	compound	candidate,gene
R3312	T10979	T10975	auxpass	was,identified
R3313	T10980	T10975	prep	for,identified
R3314	T10981	T10982	nmod	loci,4
R3315	T10982	T10980	pobj	4,for
R3316	T10983	T10982	cc	and,4
R3317	T10984	T10982	conj	7,4
R3318	T10985	T10939	punct	.,located
R3319	T10987	T10988	nsubj	Table,summarises
R3320	T10989	T10987	nummod	3,Table
R3321	T10990	T10991	det	the,genes
R3322	T10991	T10988	dobj	genes,summarises
R3323	T10992	T10991	nummod	21,genes
R3324	T10993	T10991	compound	candidate,genes
R3325	T10994	T10991	acl	identified,genes
R3326	T10995	T10994	prep	in,identified
R3327	T10996	T10997	det	this,study
R3328	T10997	T10995	pobj	study,in
R3329	T10998	T10988	punct	.,summarises
R3330	T11000	T11001	nummod	Two,genes
R3331	T11001	T11002	nsubjpass	genes,upregulated
R3332	T11003	T11001	punct	", ",genes
R3333	T11004	T11001	appos	hspa1a,genes
R3334	T11005	T11004	cc	and,hspa1a
R3335	T11006	T11004	conj	Oas1a,hspa1a
R3336	T11007	T11002	punct	", ",upregulated
R3337	T11008	T11002	auxpass	were,upregulated
R3338	T11009	T11002	prep	at,upregulated
R3339	T11010	T11011	det	the,phase
R3340	T11011	T11009	pobj	phase,at
R3341	T11012	T11011	compound	OA,phase
R3342	T11013	T11011	prep	of,phase
R3343	T11014	T11013	pobj	CIA,of
R3344	T11015	T11002	cc	and,upregulated
R3345	T11016	T11017	nsubjpass	Oas1a,upregulated
R3346	T11017	T11002	conj	upregulated,upregulated
R3347	T11018	T11017	auxpass	was,upregulated
R3348	T11019	T11017	advmod	also,upregulated
R3349	T11020	T11017	prep	at,upregulated
R3350	T11021	T11022	det	the,phase
R3351	T11022	T11020	pobj	phase,at
R3352	T11023	T11022	compound	PI,phase
R3353	T11024	T11017	punct	.,upregulated
R3354	T11026	T11027	prep	Except,downregulated
R3355	T11028	T11026	prep	for,Except
R3356	T11029	T11030	det	these,genes
R3357	T11030	T11028	pobj	genes,for
R3358	T11031	T11030	nummod	two,genes
R3359	T11032	T11027	punct	", ",downregulated
R3360	T11033	T11034	det	all,genes
R3361	T11034	T11027	nsubjpass	genes,downregulated
R3362	T11035	T11034	amod	other,genes
R3363	T11036	T11034	nummod	19,genes
R3364	T11037	T11027	auxpass	were,downregulated
R3365	T11038	T11027	prep	at,downregulated
R3366	T11039	T11040	det	the,phase
R3367	T11040	T11038	pobj	phase,at
R3368	T11041	T11040	amod	chronic,phase
R3369	T11042	T11040	prep	of,phase
R3370	T11043	T11042	pobj	CIA,of
R3371	T11044	T11027	punct	.,downregulated
R3372	T11046	T11047	det	All,genes
R3373	T11047	T11048	nsubj	genes,showed
R3374	T11049	T11047	punct	", ",genes
R3375	T11050	T11047	prep	except,genes
R3376	T11051	T11050	pobj	hspa1a,except
R3377	T11052	T11048	punct	", ",showed
R3378	T11053	T11054	compound	expression,differences
R3379	T11054	T11048	dobj	differences,showed
R3380	T11055	T11054	prep	between,differences
R3381	T11056	T11057	det	the,strains
R3382	T11057	T11055	pobj	strains,between
R3383	T11058	T11057	nummod	two,strains
R3384	T11059	T11048	prep	at,showed
R3385	T11060	T11061	det	the,phase
R3386	T11061	T11059	pobj	phase,at
R3387	T11062	T11061	compound	NC,phase
R3388	T11063	T11048	punct	.,showed
R3389	T11065	T11066	nummod	Five,genes
R3390	T11066	T11067	nsubjpass	genes,expressed
R3391	T11068	T11067	auxpass	were,expressed
R3392	T11069	T11067	advmod	differentially,expressed
R3393	T11070	T11067	prep	at,expressed
R3394	T11071	T11072	det	all,phases
R3395	T11072	T11070	pobj	phases,at
R3396	T11073	T11072	prep	of,phases
R3397	T11074	T11073	pobj	CIA,of
R3398	T11075	T11067	punct	", ",expressed
R3399	T11076	T11067	prep	including,expressed
R3400	T11077	T11078	compound	H2,Q10
R3401	T11078	T11076	pobj	Q10,including
R3402	T11079	T11078	punct	-,Q10
R3403	T11080	T11078	punct	", ",Q10
R3404	T11081	T11078	conj	Mapk14,Q10
R3405	T11082	T11081	punct	", ",Mapk14
R3406	T11083	T11081	conj	Pscd1,Mapk14
R3407	T11084	T11083	punct	", ",Pscd1
R3408	T11085	T11083	conj	Kpnb1,Pscd1
R3409	T11086	T11085	cc	and,Kpnb1
R3410	T11087	T11085	conj	Wdr1,Kpnb1
R3411	T11088	T11067	punct	.,expressed
R3412	T11090	T11091	prep	Among,had
R3413	T11092	T11093	det	these,genes
R3414	T11093	T11090	pobj	genes,Among
R3415	T11094	T11093	nummod	five,genes
R3416	T11095	T11091	punct	", ",had
R3417	T11096	T11097	compound	H2,Q10
R3418	T11097	T11091	nsubj	Q10,had
R3419	T11098	T11097	punct	-,Q10
R3420	T11099	T11100	det	a,expression
R3421	T11100	T11091	dobj	expression,had
R3422	T11101	T11102	advmod	consistently,higher
R3423	T11102	T11100	amod	higher,expression
R3424	T11103	T11091	prep	in,had
R3425	T11104	T11105	det	the,DBA
R3426	T11105	T11103	pobj	DBA,in
R3427	T11106	T11105	punct	/,DBA
R3428	T11107	T11105	nummod	1,DBA
R3429	T11108	T11091	prep	than,had
R3430	T11109	T11110	det	the,strain
R3431	T11110	T11108	pobj	strain,than
R3432	T11111	T11112	compound	FVB,N
R3433	T11112	T11110	compound	N,strain
R3434	T11113	T11112	punct	/,N
R3435	T11114	T11091	prep	in,had
R3436	T11115	T11116	det	all,phases
R3437	T11116	T11114	pobj	phases,in
R3438	T11117	T11116	compound	CIA,phases
R3439	T11118	T11091	punct	", ",had
R3440	T11119	T11120	mark	while,had
R3442	T11121	T11122	det	the,genes
R3443	T11122	T11120	nsubj	genes,had
R3444	T11123	T11122	amod	other,genes
R3445	T11124	T11122	nummod	four,genes
R3446	T11125	T11126	det	a,expression
R3447	T11126	T11120	dobj	expression,had
R3448	T11127	T11126	amod	higher,expression
R3449	T11128	T11120	prep	in,had
R3450	T11129	T11130	det	the,strain
R3451	T11130	T11128	pobj	strain,in
R3452	T11131	T11130	nmod	DBA,strain
R3453	T11132	T11131	punct	/,DBA
R3454	T11133	T11131	nummod	1,DBA
R3455	T11134	T11120	prep	at,had
R3456	T11135	T11136	det	the,stages
R3457	T11136	T11134	pobj	stages,at
R3458	T11137	T11136	amod	early,stages
R3459	T11138	T11120	punct	", ",had
R3460	T11139	T11120	prep	including,had
R3461	T11140	T11139	pobj	NC,including
R3462	T11141	T11140	punct	", ",NC
R3463	T11142	T11140	conj	PI,NC
R3464	T11143	T11142	cc	and,PI
R3465	T11144	T11142	conj	OA,PI
R3466	T11145	T11120	punct	", ",had
R3467	T11146	T11120	cc	but,had
R3468	T11147	T11148	det	a,expression
R3469	T11148	T11120	conj	expression,had
R3470	T11149	T11148	amod	lower,expression
R3471	T11150	T11148	prep	at,expression
R3472	T11151	T11152	det	the,phase
R3473	T11152	T11150	pobj	phase,at
R3474	T11153	T11152	amod	chronic,phase
R3475	T11154	T11091	punct	.,had
R3476	T11156	T11157	compound	GO,analysis
R3477	T11157	T11160	nsubj	analysis,revealed
R3478	T11158	T11157	compound	term,analysis
R3479	T11159	T11157	compound	classification,analysis
R3480	T11161	T11162	mark	that,enriched
R3481	T11162	T11160	ccomp	enriched,revealed
R3482	T11163	T11164	det	the,cluster
R3483	T11164	T11162	nsubjpass	cluster,enriched
R3484	T11165	T11164	amod	functional,cluster
R3485	T11166	T11164	prep	of,cluster
R3486	T11167	T11168	compound	protein,cascade
R3487	T11168	T11166	pobj	cascade,of
R3488	T11169	T11168	compound	kinase,cascade
R3489	T11170	T11162	auxpass	was,enriched
R3490	T11171	T11162	advmod	significantly,enriched
R3491	T11172	T11162	prep	in,enriched
R3492	T11173	T11174	det	the,genes
R3493	T11174	T11172	pobj	genes,in
R3494	T11175	T11174	nummod	21,genes
R3495	T11176	T11174	compound	candidate,genes
R3496	T11177	T11160	punct	.,revealed
R3497	T11179	T11180	det	This,cluster
R3498	T11180	T11182	nsubj	cluster,contained
R3499	T11181	T11180	amod	functional,cluster
R3500	T11183	T11184	nummod	four,genes
R3501	T11184	T11182	dobj	genes,contained
R3502	T11185	T11184	punct	", ",genes
R3503	T11186	T11184	prep	including,genes
R3504	T11187	T11186	pobj	Mapk14,including
R3505	T11188	T11187	punct	", ",Mapk14
R3506	T11189	T11187	conj	Mapk8ip3,Mapk14
R3507	T11190	T11189	punct	", ",Mapk8ip3
R3508	T11191	T11189	conj	Stat5a,Mapk8ip3
R3509	T11192	T11191	cc	and,Stat5a
R3510	T11193	T11191	conj	Gna12,Stat5a
R3511	T11194	T11182	punct	.,contained
R3525	T13481	T13482	prep	In,attempted
R3526	T13483	T13484	det	this,study
R3527	T13484	T13481	pobj	study,In
R3528	T13485	T13482	punct	", ",attempted
R3529	T13486	T13482	nsubj	we,attempted
R3530	T13487	T13482	prep	for,attempted
R3531	T13488	T13489	det	the,time
R3532	T13489	T13487	pobj	time,for
R3533	T13490	T13489	amod	first,time
R3534	T13491	T13492	aux	to,identify
R3535	T13492	T13482	xcomp	identify,attempted
R3536	T13493	T13494	amod	small,effect
R3537	T13494	T13496	compound	effect,QTL
R3538	T13495	T13494	punct	-,effect
R3539	T13496	T13492	dobj	QTL,identify
R3540	T13497	T13492	prep	in,identify
R3541	T13498	T13499	det	an,progeny
R3542	T13499	T13497	pobj	progeny,in
R3543	T13500	T13499	compound	F2,progeny
R3544	T13501	T13482	punct	.,attempted
R3545	T13503	T13504	amod	Small,effect
R3546	T13504	T13506	compound	effect,QTL
R3547	T13505	T13504	punct	-,effect
R3548	T13506	T13507	nsubjpass	QTL,defined
R3549	T13508	T13507	auxpass	are,defined
R3550	T13509	T13507	prep	as,defined
R3551	T13510	T13509	pobj	those,as
R3552	T13511	T13510	acl	reaching,those
R3553	T13512	T13513	det	the,value
R3554	T13513	T13511	dobj	value,reaching
R3555	T13514	T13513	compound	threshold,value
R3556	T13515	T13513	prep	of,value
R3557	T13516	T13517	nsubj	P,0.05
R3558	T13517	T13515	pcomp	0.05,of
R3559	T13518	T13517	punct	=,0.05
R3560	T13519	T13507	cc	but,defined
R3561	T13520	T13521	nsubj	that,reach
R3562	T13521	T13507	conj	reach,defined
R3563	T13522	T13521	aux	did,reach
R3564	T13523	T13521	neg	not,reach
R3565	T13524	T13525	det	the,value
R3566	T13525	T13521	dobj	value,reach
R3567	T13526	T13527	amod	significant,threshold
R3568	T13527	T13525	compound	threshold,value
R3569	T13528	T13525	acl	suggested,value
R3570	T13529	T13528	agent	by,suggested
R3571	T13530	T13529	pobj	Lander,by
R3572	T13531	T13530	cc	and,Lander
R3573	T13532	T13530	conj	Botstein,Lander
R3574	T13533	T13534	punct	[,26
R3575	T13534	T13528	parataxis	26,suggested
R3576	T13535	T13534	punct	],26
R3577	T13536	T13521	punct	.,reach
R3578	T13538	T13539	mark	Although,significant
R3579	T13539	T13541	advcl	significant,is
R3580	T13540	T13539	neg	not,significant
R3581	T13542	T13541	punct	", ",is
R3582	T13543	T13541	expl	there,is
R3583	T13544	T13541	attr	evidence,is
R3584	T13545	T13546	mark	that,contain
R3585	T13546	T13544	acl	contain,evidence
R3586	T13547	T13546	nsubj	most,contain
R3587	T13548	T13547	prep	of,most
R3588	T13549	T13550	det	the,QTL
R3589	T13550	T13548	pobj	QTL,of
R3590	T13551	T13550	nummod	eight,QTL
R3591	T13552	T13553	amod	small,effect
R3592	T13553	T13550	compound	effect,QTL
R3593	T13554	T13553	punct	-,effect
R3594	T13555	T13546	advmod	likely,contain
R3595	T13556	T13557	compound	susceptibility,genes
R3596	T13557	T13546	dobj	genes,contain
R3597	T13558	T13557	prep	for,genes
R3598	T13559	T13558	pobj	CIA,for
R3599	T13560	T13541	punct	.,is
R3600	T13562	T13563	advmod	First,performed
R3601	T13564	T13563	punct	", ",performed
R3602	T13565	T13563	nsubj	we,performed
R3603	T13566	T13567	det	the,analysis
R3604	T13567	T13563	dobj	analysis,performed
R3605	T13568	T13567	compound	linkage,analysis
R3606	T13569	T13563	prep	in,performed
R3607	T13570	T13571	nummod	three,datasets
R3608	T13571	T13569	pobj	datasets,in
R3609	T13572	T13571	punct	", ",datasets
R3610	T13573	T13571	prep	including,datasets
R3611	T13574	T13575	det	all,progeny
R3612	T13575	T13573	pobj	progeny,including
R3613	T13576	T13575	nummod	290,progeny
R3614	T13577	T13575	compound	F,progeny
R3615	T13578	T13575	punct	", ",progeny
R3616	T13579	T13580	nummod	76,progeny
R3617	T13580	T13575	conj	progeny,progeny
R3618	T13581	T13580	nmod	C5+,progeny
R3619	T13582	T13581	punct	/,C5+
R3620	T13583	T13581	punct	+,C5+
R3621	T13584	T13580	compound	F2,progeny
R3622	T13585	T13580	cc	and,progeny
R3623	T13586	T13587	nummod	133,progeny
R3624	T13587	T13580	conj	progeny,progeny
R3625	T13588	T13587	nmod	C5+,progeny
R3626	T13589	T13588	punct	/,C5+
R3627	T13590	T13588	punct	-,C5+
R3628	T13591	T13587	compound	F2,progeny
R3629	T13592	T13563	punct	.,performed
R3630	T13594	T13595	quantmod	Five,eight
R3631	T13595	T13598	nummod	eight,QTL
R3632	T13596	T13595	quantmod	of,eight
R3633	T13597	T13595	quantmod	the,eight
R3634	T13598	T13602	nsubjpass	QTL,identified
R3635	T13599	T13600	amod	small,effect
R3636	T13600	T13598	compound	effect,QTL
R3637	T13601	T13600	punct	-,effect
R3638	T13603	T13602	auxpass	were,identified
R3639	T13604	T13602	prep	in,identified
R3640	T13605	T13606	advmod	at,two
R3641	T13606	T13608	nummod	two,datasets
R3642	T13607	T13606	advmod	least,two
R3643	T13608	T13604	pobj	datasets,in
R3644	T13609	T13602	punct	", ",identified
R3645	T13610	T13602	advcl	suggesting,identified
R3646	T13611	T13612	mark	that,are
R3647	T13612	T13610	ccomp	are,suggesting
R3648	T13613	T13614	det	these,QTL
R3649	T13614	T13612	nsubj	QTL,are
R3650	T13615	T13612	acomp	reproducible,are
R3651	T13616	T13602	punct	.,identified
R3652	T13618	T13619	advmod	Second,overlap
R3653	T13620	T13619	punct	", ",overlap
R3654	T13621	T13622	amod	many,QTL
R3655	T13622	T13619	nsubj	QTL,overlap
R3656	T13623	T13622	acl	identified,QTL
R3657	T13624	T13623	prep	in,identified
R3658	T13625	T13626	det	the,study
R3659	T13626	T13624	pobj	study,in
R3660	T13627	T13626	amod	present,study
R3661	T13628	T13619	prep	with,overlap
R3662	T13629	T13630	compound	arthritis,QTL
R3663	T13630	T13628	pobj	QTL,with
R3664	T13631	T13632	advmod	previously,identified
R3665	T13632	T13630	acl	identified,QTL
R3666	T13633	T13630	punct	", ",QTL
R3667	T13634	T13630	prep	including,QTL
R3668	T13635	T13636	nmod	loci,1
R3669	T13636	T13634	pobj	1,including
R3670	T13637	T13636	punct	", ",1
R3671	T13638	T13636	conj	2,1
R3672	T13639	T13638	punct	", ",2
R3673	T13640	T13638	conj	5,2
R3674	T13641	T13640	cc	and,5
R3675	T13642	T13640	conj	6,5
R3676	T13643	T13619	punct	.,overlap
R3677	T13645	T13646	prep	In,revealed
R3678	T13647	T13645	pobj	addition,In
R3679	T13648	T13646	punct	", ",revealed
R3680	T13649	T13650	amod	syntenic,analysis
R3681	T13650	T13646	nsubj	analysis,revealed
R3682	T13651	T13652	mark	that,linked
R3683	T13652	T13646	ccomp	linked,revealed
R3684	T13653	T13654	det	the,regions
R3685	T13654	T13652	nsubjpass	regions,linked
R3686	T13655	T13654	nmod	counterpart,regions
R3687	T13656	T13654	amod	genomic,regions
R3688	T13657	T13654	prep	on,regions
R3689	T13658	T13659	det	the,genome
R3690	T13659	T13657	pobj	genome,on
R3691	T13660	T13659	amod	human,genome
R3692	T13661	T13659	prep	of,genome
R3693	T13662	T13661	pobj	many,of
R3694	T13663	T13662	prep	of,many
R3695	T13664	T13665	det	these,QTL
R3696	T13665	T13663	pobj	QTL,of
R3697	T13666	T13665	nummod	eight,QTL
R3698	T13667	T13652	auxpass	are,linked
R3699	T13668	T13652	prep	to,linked
R3700	T13669	T13668	pobj	RA,to
R3701	T13670	T13646	punct	.,revealed
R3702	T13672	T13673	prep	For,are
R3703	T13674	T13675	quantmod	five,eight
R3704	T13675	T13678	nummod	eight,QTL
R3705	T13676	T13675	quantmod	of,eight
R3706	T13677	T13675	quantmod	the,eight
R3707	T13678	T13672	pobj	QTL,For
R3708	T13679	T13680	amod	small,effect
R3709	T13680	T13678	compound	effect,QTL
R3710	T13681	T13680	punct	-,effect
R3711	T13682	T13683	det	the,alleles
R3712	T13683	T13673	nsubj	alleles,are
R3713	T13684	T13683	nmod	DBA,alleles
R3714	T13685	T13684	punct	/,DBA
R3715	T13686	T13684	nummod	1,DBA
R3716	T13687	T13688	det	the,alleles
R3717	T13688	T13673	attr	alleles,are
R3718	T13689	T13690	npadvmod	arthritis,enhancing
R3719	T13690	T13688	amod	enhancing,alleles
R3720	T13691	T13690	punct	-,enhancing
R3721	T13692	T13673	punct	", ",are
R3722	T13693	T13694	mark	while,are
R3723	T13694	T13673	advcl	are,are
R3724	T13695	T13696	det	the,alleles
R3725	T13696	T13694	nsubj	alleles,are
R3726	T13697	T13696	compound	FVBN,alleles
R3727	T13698	T13699	det	the,alleles
R3728	T13699	T13694	attr	alleles,are
R3729	T13700	T13701	npadvmod	arthritis,enhancing
R3730	T13701	T13699	amod	enhancing,alleles
R3731	T13702	T13701	punct	-,enhancing
R3732	T13703	T13694	prep	in,are
R3733	T13704	T13705	det	the,QTL
R3734	T13705	T13703	pobj	QTL,in
R3735	T13706	T13705	amod	other,QTL
R3736	T13707	T13705	nummod	three,QTL
R3737	T13708	T13694	punct	", ",are
R3738	T13709	T13694	advcl	indicating,are
R3739	T13710	T13711	mark	that,come
R3740	T13711	T13709	ccomp	come,indicating
R3741	T13712	T13713	det	some,genes
R3742	T13713	T13711	nsubj	genes,come
R3743	T13714	T13713	compound	susceptibility,genes
R3744	T13715	T13711	aux	could,come
R3745	T13716	T13711	prep	from,come
R3746	T13717	T13718	det	the,strain
R3747	T13718	T13716	pobj	strain,from
R3748	T13719	T13718	amod	resistant,strain
R3749	T13720	T13673	punct	.,are
R3750	T13722	T13723	advmod	Interestingly,overlap
R3751	T13724	T13723	punct	", ",overlap
R3752	T13725	T13726	nmod	loci,2
R3753	T13726	T13723	nsubj	2,overlap
R3754	T13727	T13726	cc	and,2
R3755	T13728	T13726	conj	7,2
R3756	T13729	T13723	advmod	partially,overlap
R3757	T13730	T13723	prep	with,overlap
R3758	T13731	T13732	nummod	two,QTL
R3759	T13732	T13730	pobj	QTL,with
R3760	T13733	T13734	npadvmod	arthritis,related
R3761	T13734	T13732	amod	related,QTL
R3762	T13735	T13734	punct	-,related
R3763	T13736	T13732	acl	identified,QTL
R3764	T13737	T13736	agent	by,identified
R3765	T13738	T13737	pobj	us,by
R3766	T13739	T13736	prep	in,identified
R3767	T13740	T13741	det	the,progeny
R3768	T13741	T13739	pobj	progeny,in
R3769	T13742	T13741	amod	same,progeny
R3770	T13743	T13741	compound	F2,progeny
R3771	T13744	T13745	punct	[,10
R3772	T13745	T13723	parataxis	10,overlap
R3773	T13746	T13745	punct	],10
R3774	T13747	T13723	punct	.,overlap
R3775	T13749	T13750	nsubjpass	Locus,located
R3776	T13751	T13749	nummod	2,Locus
R3777	T13752	T13750	auxpass	was,located
R3778	T13753	T13750	prep	at,located
R3779	T13754	T13755	det	the,region
R3780	T13755	T13753	pobj	region,at
R3781	T13756	T13755	amod	same,region
R3782	T13757	T13755	amod	genomic,region
R3783	T13758	T13755	prep	as,region
R3784	T13759	T13758	pobj	Cia27,as
R3785	T13760	T13759	punct	", ",Cia27
R3786	T13761	T13762	det	a,QTL
R3787	T13762	T13759	appos	QTL,Cia27
R3788	T13763	T13762	acl	controlling,QTL
R3789	T13764	T13765	compound	IgG2a,levels
R3790	T13765	T13763	dobj	levels,controlling
R3791	T13766	T13765	compound	antibody,levels
R3792	T13767	T13765	prep	to,levels
R3793	T13768	T13767	pobj	collagen,to
R3794	T13769	T13768	nummod	II,collagen
R3795	T13770	T13750	punct	.,located
R3796	T13772	T13773	advmod	Recently,refined
R3797	T13774	T13773	punct	", ",refined
R3798	T13775	T13773	nsubj	we,refined
R3799	T13776	T13773	aux	have,refined
R3800	T13777	T13778	det	this,QTL
R3801	T13778	T13773	dobj	QTL,refined
R3802	T13779	T13773	prep	into,refined
R3803	T13780	T13781	det	a,region
R3804	T13781	T13779	pobj	region,into
R3805	T13782	T13783	nummod	4.1,Mb
R3806	T13783	T13781	nmod	Mb,region
R3807	T13784	T13781	amod	genomic,region
R3808	T13785	T13773	cc	and,refined
R3809	T13786	T13773	conj	showed,refined
R3810	T13787	T13788	mark	that,regulates
R3811	T13788	T13786	ccomp	regulates,showed
R3812	T13789	T13790	det	a,gene
R3813	T13790	T13788	nsubj	gene,regulates
R3814	T13791	T13790	prep	within,gene
R3815	T13792	T13793	det	this,region
R3816	T13793	T13791	pobj	region,within
R3817	T13794	T13795	compound	CIA,severity
R3818	T13795	T13788	dobj	severity,regulates
R3819	T13796	T13788	prep	by,regulates
R3820	T13797	T13796	pcomp	controlling,by
R3821	T13798	T13799	det	the,levels
R3822	T13799	T13797	dobj	levels,controlling
R3823	T13800	T13799	compound	IgG2a,levels
R3824	T13801	T13799	compound	antibody,levels
R3825	T13802	T13799	prep	to,levels
R3826	T13803	T13802	pobj	collagen,to
R3827	T13804	T13803	nummod	II,collagen
R3828	T13805	T13806	punct	[,31
R3829	T13806	T13786	parataxis	31,showed
R3830	T13807	T13806	punct	],31
R3831	T13808	T13773	punct	.,refined
R3832	T13810	T13811	nsubj	Locus,overlaps
R3833	T13812	T13810	nummod	7,Locus
R3834	T13813	T13810	prep	on,Locus
R3835	T13814	T13813	pobj	chromosome,on
R3836	T13815	T13814	nummod	16,chromosome
R3837	T13816	T13811	prep	with,overlaps
R3838	T13817	T13816	pobj	Lp1,with
R3839	T13818	T13817	punct	", ",Lp1
R3840	T13819	T13820	dep	which,controls
R3841	T13820	T13817	relcl	controls,Lp1
R3842	T13821	T13822	compound	lymphocyte,proliferation
R3843	T13822	T13820	dobj	proliferation,controls
R3844	T13823	T13811	punct	.,overlaps
R3845	T13825	T13826	advmod	Furthermore,controls
R3846	T13827	T13826	punct	", ",controls
R3847	T13828	T13826	prep	according,controls
R3848	T13829	T13828	prep	to,according
R3849	T13830	T13831	poss	our,data
R3850	T13831	T13829	pobj	data,to
R3851	T13832	T13831	amod	unpublished,data
R3852	T13833	T13826	punct	", ",controls
R3853	T13834	T13826	nsubj	loci,controls
R3854	T13835	T13834	nummod	8,loci
R3855	T13836	T13834	prep	on,loci
R3856	T13837	T13836	pobj	chromosome,on
R3857	T13838	T13837	nummod	17,chromosome
R3858	T13839	T13840	compound	lymphocyte,adherence
R3859	T13840	T13826	dobj	adherence,controls
R3860	T13841	T13826	prep	during,controls
R3861	T13842	T13841	pobj	development,during
R3862	T13843	T13842	prep	of,development
R3863	T13844	T13843	pobj	CIA,of
R3864	T13845	T13826	punct	.,controls
R3865	T13847	T13848	advmod	Therefore,affect
R3866	T13849	T13848	punct	", ",affect
R3867	T13850	T13851	det	the,gene
R3868	T13851	T13848	nsubj	gene,affect
R3869	T13852	T13851	prep	within,gene
R3870	T13853	T13854	det	the,QTL
R3871	T13854	T13852	pobj	QTL,within
R3872	T13855	T13856	amod	small,effect
R3873	T13856	T13854	compound	effect,QTL
R3874	T13857	T13856	punct	-,effect
R3875	T13858	T13848	aux	could,affect
R3876	T13859	T13860	compound	CIA,severity
R3877	T13860	T13848	dobj	severity,affect
R3878	T13861	T13848	prep	through,affect
R3879	T13862	T13861	pcomp	controlling,through
R3880	T13863	T13864	npadvmod	arthritis,related
R3881	T13864	T13866	amod	related,phenotypes
R3882	T13865	T13864	punct	-,related
R3883	T13866	T13862	dobj	phenotypes,controlling
R3884	T13867	T13848	punct	.,affect
R3885	T13869	T13870	amod	Several,studies
R3886	T13870	T13871	nsubjpass	studies,carried
R3887	T13872	T13871	aux	have,carried
R3888	T13873	T13871	auxpass	been,carried
R3889	T13874	T13871	prt	out,carried
R3890	T13875	T13876	aux	to,detect
R3891	T13876	T13871	advcl	detect,carried
R3892	T13877	T13878	compound	gene,expression
R3893	T13878	T13876	dobj	expression,detect
R3894	T13879	T13876	prep	during,detect
R3895	T13880	T13879	pobj	CIA,during
R3896	T13881	T13871	punct	", ",carried
R3897	T13882	T13883	dep	all,used
R3898	T13883	T13871	ccomp	used,carried
R3899	T13884	T13882	prep	of,all
R3900	T13885	T13884	pobj	which,of
R3901	T13886	T13883	dobj	joints,used
R3902	T13887	T13883	prep	as,used
R3903	T13888	T13889	det	the,tissue
R3904	T13889	T13887	pobj	tissue,as
R3905	T13890	T13889	compound	target,tissue
R3906	T13891	T13892	punct	[,22
R3907	T13892	T13871	parataxis	22,carried
R3908	T13893	T13892	nummod	15,22
R3909	T13894	T13892	punct	",",22
R3910	T13895	T13892	nummod	16,22
R3911	T13896	T13892	punct	",",22
R3912	T13897	T13892	nummod	21,22
R3913	T13898	T13892	punct	",",22
R3914	T13899	T13892	punct	],22
R3915	T13900	T13871	punct	.,carried
R3916	T13902	T13903	det	This,study
R3917	T13903	T13904	nsubj	study,detected
R3918	T13905	T13904	punct	", ",detected
R3919	T13906	T13904	prep	for,detected
R3920	T13907	T13908	det	the,time
R3921	T13908	T13906	pobj	time,for
R3922	T13909	T13908	amod	first,time
R3923	T13910	T13904	punct	", ",detected
R3924	T13911	T13912	compound	gene,expression
R3925	T13912	T13904	dobj	expression,detected
R3926	T13913	T13904	prep	in,detected
R3927	T13914	T13913	pobj	LNs,in
R3928	T13915	T13904	prep	during,detected
R3929	T13916	T13915	pobj	CIA,during
R3930	T13917	T13904	punct	.,detected
R3931	T13919	T13920	nsubj	We,present
R3932	T13921	T13922	det	an,study
R3933	T13922	T13920	dobj	study,present
R3934	T13923	T13922	amod	extensive,study
R3935	T13924	T13922	prep	of,study
R3936	T13925	T13926	compound	gene,patterns
R3937	T13926	T13924	pobj	patterns,of
R3938	T13927	T13926	compound	expression,patterns
R3939	T13928	T13922	prep	in,study
R3940	T13929	T13928	pobj	LNs,in
R3941	T13930	T13929	prep	of,LNs
R3942	T13931	T13932	preconj	both,strains
R3943	T13932	T13930	pobj	strains,of
R3944	T13933	T13934	advmod	genetically,susceptible
R3945	T13934	T13932	amod	susceptible,strains
R3946	T13935	T13934	cc	and,susceptible
R3947	T13936	T13934	conj	resistant,susceptible
R3948	T13937	T13922	prep	at,study
R3949	T13938	T13939	nummod	four,phases
R3950	T13939	T13937	pobj	phases,at
R3951	T13940	T13939	amod	different,phases
R3952	T13941	T13939	prep	of,phases
R3953	T13942	T13941	pobj	CIA,of
R3954	T13943	T13920	punct	.,present
R3955	T13945	T13946	prep	In,were
R3956	T13947	T13948	det	both,strains
R3957	T13948	T13945	pobj	strains,In
R3958	T13949	T13946	punct	", ",were
R3959	T13950	T13951	advmod	differentially,regulated
R3960	T13951	T13952	amod	regulated,genes
R3961	T13952	T13946	nsubj	genes,were
R3962	T13953	T13954	advmod	highly,concentrated
R3963	T13954	T13946	acomp	concentrated,were
R3964	T13955	T13946	prep	at,were
R3965	T13956	T13957	det	the,phases
R3966	T13957	T13955	pobj	phases,at
R3967	T13958	T13957	nmod	PI,phases
R3968	T13959	T13958	cc	and,PI
R3969	T13960	T13958	conj	CA,PI
R3970	T13961	T13946	punct	", ",were
R3971	T13962	T13946	cc	and,were
R3972	T13963	T13964	advmod	only,number
R3973	T13964	T13967	nsubjpass	number,expressed
R3974	T13965	T13964	det	a,number
R3975	T13966	T13964	amod	small,number
R3976	T13967	T13946	conj	expressed,were
R3977	T13968	T13964	prep	of,number
R3978	T13969	T13968	pobj	genes,of
R3979	T13970	T13967	auxpass	were,expressed
R3980	T13971	T13967	advmod	differentially,expressed
R3981	T13972	T13967	prep	in,expressed
R3982	T13973	T13974	nummod	two,phases
R3983	T13974	T13972	pobj	phases,in
R3984	T13975	T13973	cc	or,two
R3985	T13976	T13973	conj	three,two
R3986	T13977	T13967	punct	.,expressed
R3987	T13979	T13980	nsubj	This,indicates
R3988	T13981	T13982	mark	that,were
R3989	T13982	T13980	ccomp	were,indicates
R3990	T13983	T13984	amod	biological,responses
R3991	T13984	T13982	nsubj	responses,were
R3992	T13985	T13984	prep	in,responses
R3993	T13986	T13985	pobj	LNs,in
R3994	T13987	T13982	acomp	stronger,were
R3995	T13988	T13987	prep	in,stronger
R3996	T13989	T13990	det	the,phases
R3997	T13990	T13988	pobj	phases,in
R3998	T13991	T13990	nmod	PI,phases
R3999	T13992	T13991	cc	and,PI
R4000	T13993	T13991	conj	CA,PI
R4001	T13994	T13987	prep	than,stronger
R4002	T13995	T13994	prep	in,than
R4003	T13996	T13997	det	the,phase
R4004	T13997	T13995	pobj	phase,in
R4005	T13998	T13997	compound	OA,phase
R4006	T13999	T13982	punct	", ",were
R4007	T14000	T13982	cc	and,were
R4008	T14001	T14002	det	the,responses
R4009	T14002	T14003	nsubj	responses,were
R4010	T14003	T13982	conj	were,were
R4011	T14004	T14002	prep	at,responses
R4012	T14005	T14006	amod	different,phases
R4013	T14006	T14004	pobj	phases,at
R4014	T14007	T14003	acomp	different,were
R4015	T14008	T13980	punct	.,indicates
R4016	T14010	T14011	advmod	When,comparing
R4017	T14011	T14012	advcl	comparing,found
R4018	T14013	T14014	det	the,susceptible
R4019	T14014	T14011	dative	susceptible,comparing
R4020	T14015	T14011	prep	to,comparing
R4021	T14016	T14017	det	the,resistant
R4022	T14017	T14015	pobj	resistant,to
R4023	T14018	T14011	dobj	strain,comparing
R4024	T14019	T14012	punct	", ",found
R4025	T14020	T14021	det	the,difference
R4026	T14021	T14012	nsubjpass	difference,found
R4027	T14022	T14021	amod	biggest,difference
R4028	T14023	T14012	auxpass	was,found
R4029	T14024	T14012	prep	in,found
R4030	T14025	T14026	nummod	one,cluster
R4031	T14026	T14024	pobj	cluster,in
R4032	T14027	T14026	prep	of,cluster
R4033	T14028	T14027	pobj	genes,of
R4034	T14029	T14026	punct	(,cluster
R4035	T14030	T14026	appos	cluster,cluster
R4036	T14031	T14030	nummod	IV,cluster
R4037	T14032	T14033	punct	", ",Figure
R4038	T14033	T14012	parataxis	Figure,found
R4039	T14034	T14033	nummod	2,Figure
R4040	T14035	T14033	punct	),Figure
R4041	T14036	T14012	punct	.,found
R4042	T14038	T14039	det	These,genes
R4043	T14039	T14040	nsubj	genes,had
R4044	T14041	T14042	det	a,expression
R4045	T14042	T14040	dobj	expression,had
R4046	T14043	T14042	amod	higher,expression
R4047	T14044	T14042	prep	in,expression
R4048	T14045	T14044	pobj	DBA,in
R4049	T14046	T14045	punct	/,DBA
R4050	T14047	T14045	nummod	1,DBA
R4051	T14048	T14042	prep	than,expression
R4052	T14049	T14048	prep	in,than
R4053	T14050	T14051	compound	FVB,N
R4054	T14051	T14049	pobj	N,in
R4055	T14052	T14051	punct	/,N
R4056	T14053	T14040	prep	at,had
R4057	T14054	T14055	det	the,phases
R4058	T14055	T14053	pobj	phases,at
R4059	T14056	T14055	amod	early,phases
R4060	T14057	T14055	prep	of,phases
R4061	T14058	T14057	pobj	CIA,of
R4062	T14059	T14060	punct	(,NC
R4063	T14060	T14055	parataxis	NC,phases
R4064	T14061	T14060	punct	", ",NC
R4065	T14062	T14060	conj	PI,NC
R4066	T14063	T14062	cc	and,PI
R4067	T14064	T14062	conj	OA,PI
R4068	T14065	T14060	punct	),NC
R4069	T14066	T14040	cc	and,had
R4070	T14067	T14068	det	the,pattern
R4071	T14068	T14040	conj	pattern,had
R4072	T14069	T14068	amod	opposite,pattern
R4073	T14070	T14068	compound	expression,pattern
R4074	T14071	T14068	prep	in,pattern
R4075	T14072	T14073	det	the,phase
R4076	T14073	T14071	pobj	phase,in
R4077	T14074	T14073	compound	CA,phase
R4078	T14075	T14040	punct	.,had
R4079	T14077	T14078	compound	GO,classification
R4080	T14078	T14080	nsubj	classification,revealed
R4081	T14079	T14078	compound	term,classification
R4082	T14081	T14082	mark	that,related
R4083	T14082	T14080	ccomp	related,revealed
R4084	T14083	T14084	det	these,genes
R4085	T14084	T14082	nsubjpass	genes,related
R4086	T14085	T14082	auxpass	were,related
R4087	T14086	T14082	prep	to,related
R4088	T14087	T14088	compound	lymphocyte,proliferation
R4089	T14088	T14086	pobj	proliferation,to
R4090	T14089	T14088	cc	and,proliferation
R4091	T14090	T14088	conj	activation,proliferation
R4092	T14091	T14082	punct	", ",related
R4093	T14092	T14082	advcl	suggesting,related
R4094	T14093	T14094	mark	that,are
R4095	T14094	T14092	ccomp	are,suggesting
R4096	T14095	T14094	nsubj	lymphocytes,are
R4097	T14096	T14095	prep	in,lymphocytes
R4098	T14097	T14098	det	the,strain
R4099	T14098	T14096	pobj	strain,in
R4100	T14099	T14098	nmod	DBA,strain
R4101	T14100	T14099	punct	/,DBA
R4102	T14123	T14115	advcl	existed,is
R4103	T14101	T14099	nummod	1,DBA
R4104	T14124	T14125	det	the,difference
R4105	T14102	T14103	advmod	more,activated
R4106	T14125	T14123	nsubj	difference,existed
R4107	T14126	T14125	compound	expression,difference
R4109	T14103	T14094	acomp	activated,are
R4110	T14128	T14129	det	the,strains
R4112	T14104	T14103	prep	than,activated
R4113	T14130	T14129	nummod	two,strains
R4114	T14131	T14123	prep	in,existed
R4115	T14132	T14131	pobj	mice,in
R4116	T14105	T14104	pobj	those,than
R4117	T14133	T14132	prep	without,mice
R4118	T14134	T14133	pobj	immunisation,without
R4119	T14135	T14115	punct	.,is
R4120	T14106	T14105	prep	in,those
R4121	T14137	T14138	advmod	Additionally,upregulated
R4122	T14107	T14108	det	the,strain
R4123	T14139	T14138	punct	", ",upregulated
R4124	T14108	T14106	pobj	strain,in
R4125	T14140	T14141	det	some,genes
R4126	T14141	T14138	nsubjpass	genes,upregulated
R4127	T14142	T14141	acl	related,genes
R4128	T14109	T14110	compound	FVB,N
R4129	T14143	T14142	prep	to,related
R4130	T14144	T14145	det	the,response
R4131	T14110	T14108	compound	N,strain
R4132	T14145	T14143	pobj	response,to
R4133	T14146	T14145	amod	immune,response
R4134	T14147	T14138	auxpass	were,upregulated
R4135	T14148	T14138	prep	in,upregulated
R4136	T14149	T14150	det	the,strain
R4137	T14150	T14148	pobj	strain,in
R4138	T14111	T14110	punct	/,N
R4139	T14151	T14150	nmod	DBA,strain
R4140	T14152	T14151	punct	/,DBA
R4141	T14153	T14151	nummod	1,DBA
R4142	T14112	T14080	punct	.,revealed
R4143	T14154	T14148	cc	but,in
R4144	T14155	T14154	neg	not,but
R4145	T14156	T14148	conj	in,in
R4146	T14157	T14158	det	the,strain
R4147	T14114	T14115	advmod	However,is
R4148	T14158	T14156	pobj	strain,in
R4149	T14159	T14160	compound	FVB,N
R4150	T14160	T14158	compound	N,strain
R4151	T14161	T14160	punct	/,N
R4152	T14116	T14115	punct	", ",is
R4153	T14162	T14138	prep	during,upregulated
R4154	T14163	T14162	pobj	CIA,during
R4155	T14164	T14138	punct	.,upregulated
R4156	T14166	T14167	det	These,differences
R4157	T14117	T14118	det	this,difference
R4158	T14167	T14168	nsubj	differences,explain
R4159	T14169	T14168	aux	could,explain
R4160	T14118	T14115	nsubj	difference,is
R4161	T14170	T14171	advmod	why,occurred
R4162	T14119	T14115	neg	not,is
R4163	T14120	T14121	npadvmod	CIA,specific
R4164	T14171	T14168	ccomp	occurred,explain
R4165	T14172	T14173	det	a,response
R4166	T14121	T14115	acomp	specific,is
R4167	T14173	T14171	nsubj	response,occurred
R4168	T14174	T14173	amod	higher,response
R4169	T14175	T14173	compound	antibody,response
R4170	T14122	T14123	mark	because,existed
R4171	T14176	T14173	prep	to,response
R4172	T14177	T14176	pobj	collagen,to
R4173	T14178	T14177	nummod	II,collagen
R4174	T14179	T14171	prep	in,occurred
R4175	T14229	T14228	prep	to,according
R4176	T14180	T14181	det	the,strain
R4177	T14181	T14179	pobj	strain,in
R4178	T14182	T14181	nmod	DBA,strain
R4179	T14183	T14182	punct	/,DBA
R4180	T14230	T14231	poss	their,patterns
R4181	T14184	T14182	nummod	1,DBA
R4182	T14185	T14171	prep	compared,occurred
R4183	T14231	T14229	pobj	patterns,to
R4184	T14186	T14185	prep	to,compared
R4185	T14187	T14188	det	the,strain
R4186	T14188	T14186	pobj	strain,to
R4187	T14189	T14190	compound	FVB,N
R4188	T14190	T14188	compound	N,strain
R4189	T14232	T14233	compound	gene,expression
R4190	T14191	T14190	punct	/,N
R4191	T14192	T14168	punct	", ",explain
R4192	T14193	T14168	cc	and,explain
R4193	T14194	T14195	aux	might,explain
R4194	T14233	T14231	compound	expression,patterns
R4195	T14195	T14168	conj	explain,explain
R4196	T14234	T14213	prep	during,identified
R4197	T14196	T14195	advmod	partially,explain
R4198	T14197	T14198	det	the,difference
R4199	T14198	T14195	dobj	difference,explain
R4200	T14199	T14198	prep	of,difference
R4201	T14235	T14234	pobj	CIA,during
R4202	T14200	T14201	det	the,susceptibility
R4203	T14201	T14199	pobj	susceptibility,of
R4204	T14202	T14201	prep	to,susceptibility
R4205	T14203	T14202	pobj	CIA,to
R4206	T14236	T14235	cc	and,CIA
R4207	T14204	T14198	prep	between,difference
R4208	T14205	T14206	det	both,strains
R4209	T14206	T14204	pobj	strains,between
R4210	T14237	T14238	poss	their,locations
R4211	T14207	T14168	punct	.,explain
R4212	T14209	T14210	compound	Twenty,one
R4213	T14238	T14235	conj	locations,CIA
R4214	T14210	T14212	nummod	one,genes
R4215	T14211	T14210	punct	-,one
R4216	T14212	T14213	nsubjpass	genes,identified
R4217	T14239	T14238	amod	genomic,locations
R4218	T14214	T14213	auxpass	were,identified
R4219	T14215	T14213	prep	as,identified
R4220	T14216	T14217	amod	potential,genes
R4221	T14240	T14213	punct	.,identified
R4222	T14217	T14215	pobj	genes,as
R4223	T14218	T14217	compound	candidate,genes
R4224	T14219	T14213	prep	for,identified
R4225	T14242	T14243	det	No,genes
R4226	T14220	T14221	quantmod	six,eight
R4227	T14221	T14224	nummod	eight,QTL
R4228	T14222	T14221	quantmod	of,eight
R4229	T14223	T14221	quantmod	the,eight
R4230	T14243	T14245	nsubjpass	genes,located
R4231	T14224	T14219	pobj	QTL,for
R4232	T14225	T14226	amod	small,effect
R4233	T14226	T14224	compound	effect,QTL
R4234	T14244	T14243	compound	candidate,genes
R4235	T14227	T14226	punct	-,effect
R4236	T14228	T14213	prep	according,identified
R4237	T14246	T14245	auxpass	were,located
R4238	T14247	T14245	prep	in,located
R4239	T14248	T14249	nmod	QTL,4
R4240	T14336	T14337	advmod	Moreover,attenuate
R4241	T14249	T14247	pobj	4,in
R4242	T14338	T14337	punct	", ",attenuate
R4243	T14339	T14337	nsubj	inhibitors,attenuate
R4244	T14340	T14339	prep	of,inhibitors
R4245	T14341	T14342	compound	p38,MAPK
R4246	T14250	T14249	cc	and,4
R4247	T14342	T14340	pobj	MAPK,of
R4248	T14343	T14337	aux	could,attenuate
R4249	T14344	T14337	dobj	CIA,attenuate
R4250	T14251	T14249	conj	7,4
R4251	T14345	T14337	prep	in,attenuate
R4252	T14252	T14245	punct	", ",located
R4253	T14346	T14345	pobj	rats,in
R4254	T14347	T14348	punct	[,33
R4255	T14348	T14337	parataxis	33,attenuate
R4256	T14349	T14348	punct	],33
R4257	T14253	T14245	advcl	suggesting,located
R4258	T14254	T14255	mark	that,affect
R4259	T14350	T14337	punct	", ",attenuate
R4260	T14351	T14337	cc	and,attenuate
R4261	T14352	T14353	compound	p38,MAPK
R4262	T14255	T14253	ccomp	affect,suggesting
R4263	T14353	T14354	nsubj	MAPK,becoming
R4264	T14354	T14337	conj	becoming,attenuate
R4265	T14355	T14354	aux	is,becoming
R4266	T14356	T14357	det	a,target
R4267	T14256	T14257	compound	QTG,polymorphisms
R4268	T14357	T14354	attr	target,becoming
R4269	T14358	T14357	amod	potential,target
R4270	T14359	T14357	amod	therapeutic,target
R4271	T14257	T14255	nsubj	polymorphisms,affect
R4272	T14360	T14354	prep	in,becoming
R4273	T14361	T14360	pobj	RA,in
R4274	T14362	T14363	punct	[,32
R4275	T14363	T14354	parataxis	32,becoming
R4276	T14258	T14257	prep	of,polymorphisms
R4277	T14364	T14363	punct	],32
R4278	T14365	T14337	punct	.,attenuate
R4279	T14367	T14368	nsubj	Stat5a,is
R4280	T14259	T14260	det	the,genes
R4281	T14369	T14367	punct	", ",Stat5a
R4282	T14370	T14371	det	a,gene
R4283	T14260	T14258	pobj	genes,of
R4284	T14371	T14367	appos	gene,Stat5a
R4285	T14372	T14371	compound	candidate,gene
R4286	T14373	T14371	prep	for,gene
R4287	T14374	T14373	pobj	loci,for
R4288	T14261	T14260	compound	susceptibility,genes
R4289	T14375	T14374	nummod	6,loci
R4290	T14376	T14368	punct	", ",is
R4291	T14377	T14378	det	an,molecule
R4292	T14378	T14368	attr	molecule,is
R4293	T14379	T14378	amod	essential,molecule
R4294	T14380	T14378	prep	for,molecule
R4295	T14381	T14382	compound	lymphoid,development
R4296	T14262	T14257	prep	inside,polymorphisms
R4297	T14382	T14380	pobj	development,for
R4298	T14383	T14382	cc	and,development
R4299	T14384	T14382	conj	differentiation,development
R4300	T14385	T14386	punct	[,34
R4301	T14263	T14264	det	these,QTL
R4302	T14386	T14368	parataxis	34,is
R4303	T14387	T14386	punct	],34
R4304	T14388	T14368	punct	.,is
R4305	T14264	T14262	pobj	QTL,inside
R4306	T14390	T14391	npadvmod	Stat5a,deficient
R4307	T14391	T14393	amod	deficient,mice
R4308	T14265	T14264	nummod	two,QTL
R4309	T14392	T14391	punct	-,deficient
R4310	T14393	T14394	nsubjpass	mice,reported
R4311	T14266	T14255	aux	might,affect
R4312	T14395	T14394	auxpass	were,reported
R4313	T14396	T14397	aux	to,lose
R4314	T14397	T14394	xcomp	lose,reported
R4315	T14267	T14255	neg	not,affect
R4316	T14398	T14397	dobj	tolerance,lose
R4317	T14399	T14397	punct	", ",lose
R4318	T14400	T14397	advcl	resulting,lose
R4319	T14401	T14400	prep	in,resulting
R4320	T14268	T14269	det	the,phenotype
R4321	T14402	T14403	det	the,development
R4322	T14403	T14401	pobj	development,in
R4323	T14404	T14403	prep	of,development
R4324	T14269	T14255	dobj	phenotype,affect
R4325	T14405	T14406	amod	autoimmune,diseases
R4326	T14406	T14404	pobj	diseases,of
R4327	T14270	T14255	prep	by,affect
R4328	T14407	T14394	punct	.,reported
R4329	T14409	T14410	nsubjpass	Stat5a,suggested
R4330	T14271	T14270	pcomp	regulating,by
R4331	T14411	T14410	auxpass	is,suggested
R4332	T14412	T14413	aux	to,contribute
R4333	T14272	T14273	compound	gene,expression
R4334	T14413	T14410	xcomp	contribute,suggested
R4335	T14414	T14413	prep	to,contribute
R4336	T14415	T14414	pobj	tolerance,to
R4337	T14273	T14271	dobj	expression,regulating
R4338	T14416	T14413	prep	through,contribute
R4339	T14417	T14416	pobj	maintenance,through
R4340	T14418	T14417	prep	of,maintenance
R4341	T14419	T14420	det	the,population
R4342	T14420	T14418	pobj	population,of
R4343	T14421	T14420	nmod	CD4+CD25+,population
R4344	T14422	T14420	amod	regulatory,population
R4345	T14274	T14245	punct	.,located
R4346	T14423	T14424	compound	T,cell
R4347	T14424	T14420	compound	cell,population
R4348	T14425	T14426	punct	[,35
R4349	T14426	T14410	parataxis	35,suggested
R4350	T14276	T14277	quantmod	Two,21
R4351	T14427	T14426	punct	],35
R4352	T14428	T14410	punct	.,suggested
R4353	T14430	T14431	advmod	Therefore,presented
R4354	T14277	T14280	nummod	21,genes
R4355	T14432	T14431	punct	", ",presented
R4356	T14278	T14277	quantmod	of,21
R4357	T14433	T14431	nsubj	we,presented
R4358	T14434	T14431	aux	have,presented
R4359	T14435	T14436	det	a,strategy
R4360	T14436	T14431	dobj	strategy,presented
R4361	T14279	T14277	quantmod	the,21
R4362	T14437	T14438	aux	to,identify
R4363	T14438	T14436	advcl	identify,strategy
R4364	T14280	T14282	nsubjpass	genes,reported
R4365	T14439	T14440	amod	small,effect
R4366	T14281	T14280	compound	candidate,genes
R4367	T14440	T14442	compound	effect,QTL
R4368	T14283	T14282	auxpass	were,reported
R4369	T14284	T14285	aux	to,involved
R4370	T14441	T14440	punct	-,effect
R4371	T14285	T14282	xcomp	involved,reported
R4372	T14442	T14438	dobj	QTL,identify
R4373	T14443	T14438	cc	and,identify
R4374	T14444	T14438	conj	search,identify
R4375	T14286	T14285	auxpass	be,involved
R4376	T14445	T14444	prep	for,search
R4377	T14446	T14447	amod	potential,genes
R4378	T14287	T14285	prep	in,involved
R4379	T14447	T14445	pobj	genes,for
R4380	T14448	T14447	compound	candidate,genes
R4381	T14449	T14444	prep	within,search
R4382	T14450	T14449	pobj	them,within
R4383	T14288	T14287	pobj	arthritis,in
R4384	T14451	T14431	punct	.,presented
R4385	T14289	T14282	punct	.,reported
R4386	T14453	T14454	advmod	However,is
R4387	T14455	T14454	punct	", ",is
R4388	T14291	T14292	nsubj	Mapk14,regulates
R4389	T14456	T14454	nsubj	it,is
R4390	T14457	T14454	acomp	noteworthy,is
R4391	T14458	T14459	mark	that,lead
R4392	T14459	T14454	ccomp	lead,is
R4393	T14460	T14461	det	the,threshold
R4394	T14461	T14459	nsubj	threshold,lead
R4395	T14462	T14461	amod	low,threshold
R4396	T14293	T14291	punct	", ",Mapk14
R4397	T14463	T14461	amod	statistical,threshold
R4398	T14464	T14461	cc	and,threshold
R4399	T14465	T14466	amod	small,number
R4400	T14466	T14461	conj	number,threshold
R4401	T14294	T14295	det	a,gene
R4402	T14467	T14466	prep	of,number
R4403	T14468	T14467	pobj	animals,of
R4404	T14469	T14466	prep	per,number
R4405	T14295	T14291	nmod	gene,Mapk14
R4406	T14470	T14469	pobj	group,per
R4407	T14471	T14459	aux	could,lead
R4408	T14472	T14459	prep	to,lead
R4409	T14296	T14295	nmod	candidate,gene
R4410	T14473	T14474	det	some,results
R4411	T14474	T14472	pobj	results,to
R4412	T14475	T14476	amod	false,positive
R4413	T14297	T14295	prep	for,gene
R4414	T14476	T14474	amod	positive,results
R4415	T14477	T14454	punct	.,is
R4416	T14298	T14297	pobj	locus,for
R4417	T14479	T14480	prep	On,be
R4418	T14481	T14482	det	the,level
R4419	T14299	T14298	nummod	8,locus
R4420	T14482	T14479	pobj	level,On
R4421	T14483	T14482	compound	genome,level
R4422	T14484	T14480	punct	", ",be
R4423	T14300	T14295	cc	and,gene
R4424	T14485	T14480	nsubj	some,be
R4425	T14486	T14485	prep	of,some
R4426	T14487	T14488	det	the,QTL
R4427	T14488	T14486	pobj	QTL,of
R4428	T14301	T14302	advmod	also,called
R4429	T14489	T14488	nummod	eight,QTL
R4430	T14490	T14491	amod	small,effect
R4431	T14491	T14488	compound	effect,QTL
R4432	T14302	T14295	conj	called,gene
R4433	T14492	T14491	punct	-,effect
R4434	T14493	T14488	acl	identified,QTL
R4435	T14494	T14493	advcl	using,identified
R4436	T14495	T14496	det	a,value
R4437	T14303	T14304	nmod	p38,kinase
R4438	T14496	T14494	dobj	value,using
R4439	T14497	T14498	advmod	very,low
R4440	T14498	T14496	amod	low,value
R4441	T14304	T14309	nmod	kinase,alpha
R4442	T14499	T14496	compound	threshold,value
R4443	T14500	T14501	punct	(,0.05
R4444	T14501	T14496	parataxis	0.05,value
R4445	T14502	T14501	nsubj	P,0.05
R4446	T14503	T14501	punct	<,0.05
R4447	T14504	T14501	punct	),0.05
R4448	T14305	T14306	npadvmod	mitogen,activated
R4449	T14505	T14480	aux	could,be
R4450	T14506	T14507	amod	false,positives
R4451	T14507	T14480	attr	positives,be
R4452	T14306	T14304	amod	activated,kinase
R4453	T14508	T14480	punct	.,be
R4454	T14510	T14511	prep	For,identified
R4455	T14307	T14306	punct	-,activated
R4456	T14512	T14510	pobj	example,For
R4457	T14513	T14511	punct	", ",identified
R4458	T14308	T14304	nmod	protein,kinase
R4459	T14514	T14511	nsubjpass	locus,identified
R4460	T14515	T14514	nummod	4,locus
R4461	T14309	T14302	oprd	alpha,called
R4462	T14310	T14304	punct	(,kinase
R4463	T14516	T14511	auxpass	was,identified
R4464	T14311	T14304	appos	MAPK,kinase
R4465	T14517	T14511	prep	with,identified
R4466	T14518	T14519	det	a,value
R4467	T14519	T14517	pobj	value,with
R4468	T14312	T14309	punct	),alpha
R4469	T14520	T14519	amod	low,value
R4470	T14521	T14519	compound	P,value
R4471	T14522	T14511	cc	and,identified
R4472	T14313	T14292	punct	", ",regulates
R4473	T14523	T14524	aux	does,overlap
R4474	T14524	T14511	conj	overlap,identified
R4475	T14525	T14524	neg	not,overlap
R4476	T14314	T14315	det	the,production
R4477	T14315	T14292	dobj	production,regulates
R4480	T14316	T14315	prep	of,production
R4484	T14317	T14318	npadvmod	arthritis,essential
R4487	T14318	T14320	amod	essential,cytokines
R4490	T14319	T14318	punct	-,essential
R4493	T14539	T14535	punct	", ",result
R4494	T14320	T14316	pobj	cytokines,of
R4495	T14540	T14541	det	the,number
R4496	T14541	T14535	nsubj	number,result
R4497	T14542	T14541	amod	small,number
R4498	T14543	T14541	prep	of,number
R4499	T14544	T14543	pobj	animals,of
R4500	T14545	T14541	prep	per,number
R4501	T14546	T14545	pobj	group,per
R4502	T14321	T14320	punct	", ",cytokines
R4503	T14322	T14323	amod	such,as
R4504	T14323	T14320	prep	as,cytokines
R4505	T14547	T14541	cc	and,number
R4506	T14548	T14549	det	the,threshold
R4507	T14549	T14541	conj	threshold,number
R4508	T14324	T14325	compound	tumour,factor
R4509	T14550	T14549	amod	low,threshold
R4510	T14551	T14549	acl	used,threshold
R4511	T14552	T14553	aux	to,detect
R4512	T14325	T14323	pobj	factor,as
R4513	T14553	T14551	advcl	detect,used
R4514	T14554	T14555	compound	gene,expression
R4515	T14555	T14553	dobj	expression,detect
R4516	T14326	T14325	compound	necrosis,factor
R4517	T14556	T14535	aux	could,result
R4518	T14557	T14535	advmod	also,result
R4519	T14327	T14325	cc	and,factor
R4520	T14558	T14535	prep	in,result
R4521	T14559	T14560	amod	false,positives
R4522	T14560	T14558	pobj	positives,in
R4523	T14561	T14535	prep	in,result
R4524	T14328	T14325	conj	interleukin,factor
R4525	T14562	T14563	det	the,genes
R4526	T14563	T14561	pobj	genes,in
R4527	T14329	T14328	punct	-,interleukin
R4528	T14564	T14565	advmod	differentially,expressed
R4529	T14565	T14563	amod	expressed,genes
R4530	T14566	T14535	punct	.,result
R4531	T14330	T14328	nummod	1,interleukin
R4532	T14568	T14569	advmod	Furthermore,result
R4533	T14331	T14332	punct	[,32
R4534	T14570	T14569	punct	", ",result
R4535	T14571	T14572	det	the,expression
R4536	T14572	T14569	nsubj	expression,result
R4537	T14332	T14292	parataxis	32,regulates
R4538	T14573	T14572	amod	differential,expression
R4539	T14574	T14572	prep	of,expression
R4540	T14575	T14576	det	a,gene
R4541	T14576	T14574	pobj	gene,of
R4542	T14333	T14332	punct	],32
R4543	T14577	T14569	aux	could,result
R4544	T14578	T14579	preconj	not,from
R4545	T14579	T14569	prep	from,result
R4546	T14334	T14292	punct	.,regulates
R4547	T14580	T14578	advmod	only,not
R4548	T14581	T14582	compound	allele,difference
R4549	T14582	T14579	pobj	difference,from
R4550	T14583	T14582	prep	between,difference
R4551	T14584	T14585	nummod	two,strains
R4552	T14585	T14583	pobj	strains,between
R4553	T14586	T14579	punct	", ",from
R4554	T14587	T14579	cc	but,from
R4555	T14588	T14587	advmod	also,but
R4556	T14589	T14579	conj	from,from
R4557	T14590	T14591	amod	other,factors
R4558	T14591	T14589	pobj	factors,from
R4559	T14592	T14569	punct	.,result
R4560	T14594	T14595	advmod	Therefore,confirmed
R4561	T14596	T14595	punct	", ",confirmed
R4562	T14597	T14598	poss	our,findings
R4563	T14598	T14595	nsubjpass	findings,confirmed
R4564	T14599	T14595	aux	should,confirmed
R4565	T14600	T14595	auxpass	be,confirmed
R4566	T14601	T14595	prep	in,confirmed
R4567	T14602	T14603	amod	future,studies
R4568	T14603	T14601	pobj	studies,in
R4569	T14604	T14595	punct	.,confirmed
R4570	T14922	T14923	nsubj	We,present
R4571	T14924	T14925	det	a,strategy
R4572	T14925	T14923	dobj	strategy,present
R4573	T14926	T14927	aux	to,search
R4574	T14927	T14925	advcl	search,strategy
R4575	T14928	T14929	compound	candidate,genes
R4576	T14929	T14927	dobj	genes,search
R4577	T14930	T14927	prep	for,search
R4578	T14931	T14932	amod	small,effect
R4579	T14932	T14934	compound	effect,QTL
R4580	T14933	T14932	punct	-,effect
R4581	T14934	T14930	pobj	QTL,for
R4582	T14935	T14923	punct	.,present
R4583	T14937	T14938	prep	With,identified
R4584	T14939	T14940	det	this,strategy
R4585	T14940	T14937	pobj	strategy,With
R4586	T14941	T14938	punct	", ",identified
R4587	T14942	T14938	nsubj	we,identified
R4588	T14943	T14944	nummod	21,genes
R4589	T14944	T14938	dobj	genes,identified
R4590	T14945	T14944	compound	candidate,genes
R4591	T14946	T14944	prep	for,genes
R4592	T14947	T14948	nummod	8,susceptibility
R4593	T14948	T14946	pobj	susceptibility,for
R4594	T14949	T14950	amod	small,effect
R4595	T14950	T14948	nmod	effect,susceptibility
R4596	T14951	T14950	punct	-,effect
R4597	T14952	T14953	npadvmod	QTL,regulating
R4598	T14953	T14948	amod	regulating,susceptibility
R4599	T14954	T14948	compound	CIA,susceptibility
R4600	T14955	T14938	punct	.,identified
R4601	T14957	T14958	poss	Our,studies
R4602	T14958	T14960	nsubjpass	studies,carried
R4603	T14959	T14958	amod	future,studies
R4604	T14961	T14960	aux	will,carried
R4605	T14962	T14960	auxpass	be,carried
R4606	T14963	T14960	prt	out,carried
R4607	T14964	T14960	advcl	using,carried
R4608	T14965	T14966	nummod	two,approaches
R4609	T14966	T14964	dobj	approaches,using
R4610	T14967	T14960	punct	.,carried
R4611	T14969	T14970	det	The,first
R4612	T14970	T14971	nsubj	first,generating
R4613	T14972	T14971	aux	is,generating
R4614	T14973	T14974	amod	congenic,animals
R4615	T14974	T14971	dobj	animals,generating
R4616	T14975	T14971	prep	for,generating
R4617	T14976	T14977	amod	promising,QTL
R4618	T14977	T14975	pobj	QTL,for
R4619	T14978	T14979	amod	small,effect
R4620	T14979	T14977	compound	effect,QTL
R4621	T14980	T14979	punct	-,effect
R4622	T14981	T14982	dep	that,have
R4623	T14982	T14977	relcl	have,QTL
R4624	T14983	T14984	advmod	relatively,high
R4625	T14984	T14985	amod	high,values
R4626	T14985	T14982	dobj	values,have
R4627	T14986	T14985	compound	P,values
R4628	T14987	T14982	cc	and,have
R4629	T14988	T14982	conj	overlap,have
R4630	T14989	T14988	prep	with,overlap
R4631	T14990	T14991	advmod	previously,identified
R4632	T14991	T14993	amod	identified,QTL
R4633	T14992	T14991	punct	-,identified
R4634	T14993	T14989	pobj	QTL,with
R4635	T14994	T14993	compound	arthritis,QTL
R4636	T14995	T14971	punct	.,generating
R4637	T14997	T14998	det	The,approach
R4638	T14998	T15000	nsubj	approach,is
R4639	T14999	T14998	amod	second,approach
R4640	T15001	T15000	xcomp	investigating,is
R4641	T15002	T15003	compound	candidate,genes
R4642	T15003	T15001	dobj	genes,investigating
R4643	T15004	T15001	advcl	using,investigating
R4644	T15005	T15006	preconj	both,mouse
R4645	T15006	T15007	nmod	mouse,studies
R4646	T15007	T15004	dobj	studies,using
R4647	T15008	T15006	cc	and,mouse
R4648	T15009	T15006	conj	human,mouse
R4649	T15010	T15000	punct	.,is
R4650	T15012	T15013	compound	Candidate,genes
R4651	T15013	T15014	nsubjpass	genes,selected
R4652	T15015	T15014	aux	will,selected
R4653	T15016	T15014	auxpass	be,selected
R4654	T15017	T15014	prep	according,selected
R4655	T15018	T15017	prep	to,according
R4656	T15019	T15020	poss	their,function
R4657	T15020	T15018	pobj	function,to
R4658	T15021	T15020	cc	and,function
R4659	T15022	T15020	conj	polymorphism,function
R4660	T15023	T15022	prep	between,polymorphism
R4661	T15024	T15025	det	the,strains
R4662	T15025	T15023	pobj	strains,between
R4663	T15026	T15025	nummod	two,strains
R4664	T15027	T15014	punct	.,selected
R4665	T15029	T15030	advmod	Thereafter,generate
R4666	T15031	T15030	punct	", ",generate
R4667	T15032	T15030	nsubj	we,generate
R4668	T15033	T15030	aux	will,generate
R4669	T15034	T15035	amod	knock,mice
R4670	T15035	T15030	dobj	mice,generate
R4671	T15036	T15034	punct	-,knock
R4672	T15037	T15034	prt	out,knock
R4673	T15038	T15039	aux	to,investigate
R4674	T15039	T15030	advcl	investigate,generate
R4675	T15040	T15041	det	the,role
R4676	T15041	T15039	dobj	role,investigate
R4677	T15042	T15041	prep	of,role
R4678	T15043	T15044	det	the,genes
R4679	T15044	T15042	pobj	genes,of
R4680	T15045	T15039	prep	in,investigate
R4681	T15046	T15045	pobj	CIA,in
R4682	T15047	T15030	punct	.,generate
R4683	T15049	T15050	prep	For,investigate
R4684	T15051	T15052	det	the,loci
R4685	T15052	T15049	pobj	loci,For
R4686	T15053	T15054	poss	whose,counterparts
R4687	T15054	T15055	dep	counterparts,linked
R4688	T15055	T15052	relcl	linked,loci
R4689	T15056	T15054	prep	on,counterparts
R4690	T15057	T15058	det	the,genome
R4691	T15058	T15056	pobj	genome,on
R4692	T15059	T15058	amod	human,genome
R4693	T15060	T15055	auxpass	are,linked
R4694	T15061	T15055	prep	to,linked
R4695	T15062	T15061	pobj	RA,to
R4696	T15063	T15050	punct	", ",investigate
R4697	T15064	T15050	nsubj	we,investigate
R4698	T15065	T15050	aux	will,investigate
R4699	T15066	T15067	det	the,genes
R4700	T15067	T15050	dobj	genes,investigate
R4701	T15068	T15067	compound	candidate,genes
R4702	T15069	T15050	advcl	using,investigate
R4703	T15070	T15071	compound	case,control
R4704	T15071	T15073	compound	control,studies
R4705	T15072	T15071	punct	-,control
R4706	T15073	T15069	dobj	studies,using
R4707	T15074	T15073	compound	association,studies
R4708	T15075	T15069	prep	in,using
R4709	T15076	T15077	compound	RA,cohorts
R4710	T15077	T15075	pobj	cohorts,in
R4711	T15078	T15050	punct	.,investigate
R1459	T4716	T4715	punct	-,effect
R1475	T4732	T4731	punct	-,square
R1592	T5129	T5128	punct	-,Packard
R1665	T5679	T5678	compound	group,means
R1671	T5685	T5684	amod	absolute,difference
R1673	T5687	T5684	prep	between,difference
R1674	T5688	T5689	det	the,groups
R1681	T5695	T5696	compound	P,value
R1682	T5696	T5694	compound	value,threshold
R1686	T5700	T5699	amod	unpaired,test
R1687	T5701	T5699	compound	t,test
R1688	T5702	T5699	punct	-,test
R2448	T8324	T8322	dobj	profiles,detected
R2520	T8402	T8405	nsubj	CV,indicated
R2544	T8428	T8424	pobj	genes,for
R2696	T8592	T8586	nsubjpass	genes,expressed
R1036	T4060	T4059	punct	/,N
R1053	T4078	T4077	punct	-,controlled
R1060	T4085	T4084	punct	/,dark
R1109	T4140	T4139	punct	/,N
R1113	T4144	T4143	compound	DBA,1J
R1114	T4145	T4143	punct	/,1J
R1118	T4149	T4148	punct	/,N
R1196	T4231	T4230	punct	-,score
R1213	T4249	T4248	punct	/,N
R1217	T4253	T4252	punct	/,1J
R1314	T4360	T4359	punct	/,N
R1359	T4409	T4408	punct	/,N
R3200	T10859	T10857	pobj	QTL,to
R3308	T10975	T10939	advcl	identified,located
R3441	T11120	T11091	advcl	had,had
R1917	T7178	T7176	ccomp	be,indicating
R1927	T7188	T7182	relcl	were,QTL
R1936	T7197	T7195	dobj	value,reach
R1956	T7219	T7217	dobj	value,using
R1962	T7225	T7219	parataxis	0.05,value
R2010	T7275	T7234	nsubjpass	QTL,masked
R2038	T7305	T7303	dobj	progeny,containing
R2081	T7350	T7331	advcl	varying,linked
R2317	T7604	T7607	nmod	C,progeny
R2332	T7620	T7623	nsubjpass	regions,reported
R2436	T7727	T7644	parataxis	4,are
R210	T2422	T2423	nsubjpass	Susceptibility,controlled
R211	T2424	T2422	prep	to,Susceptibility
R212	T2425	T2426	advmod	most,diseases
R215	T2428	T2423	auxpass	is,controlled
R216	T2429	T2423	agent	by,controlled
R217	T2430	T2431	amod	many,genes
R218	T2431	T2429	pobj	genes,by
R219	T2432	T2431	punct	", ",genes
R220	T2433	T2434	advmod	each,having
R221	T2434	T2431	acl	having,genes
R222	T2435	T2436	det	a,effect
R225	T2438	T2436	prep	on,effect
R226	T2439	T2440	det	the,disease
R227	T2440	T2438	pobj	disease,on
R228	T2441	T2423	punct	.,controlled
R229	T2443	T2444	nummod	One,example
R230	T2444	T2445	nsubj	example,is
R231	T2446	T2447	amod	rheumatoid,arthritis
R232	T2447	T2445	attr	arthritis,is
R233	T2448	T2447	punct	(,arthritis
R234	T2449	T2447	appos	RA,arthritis
R235	T2450	T2447	punct	),arthritis
R236	T2451	T2447	punct	", ",arthritis
R237	T2452	T2453	det	a,disease
R243	T2458	T2445	punct	.,is
R244	T2460	T2461	amod	Several,studies
R245	T2461	T2462	nsubjpass	studies,carried
R246	T2463	T2462	aux	have,carried
R247	T2464	T2462	auxpass	been,carried
R248	T2465	T2462	prt	out,carried
R249	T2466	T2467	aux	to,detect
R250	T2467	T2462	advcl	detect,carried
R251	T2468	T2469	det	the,basis
R254	T2471	T2469	prep	of,basis
R255	T2472	T2471	pobj	RA,of
R256	T2473	T2462	punct	", ",carried
R257	T2474	T2462	cc	and,carried
R258	T2475	T2476	amod	more,30
R265	T2482	T2480	dobj	evidence,shown
R266	T2483	T2482	prep	of,evidence
R267	T2484	T2483	pobj	linkage,of
R268	T2485	T2484	prep	to,linkage
R269	T2486	T2487	det	the,disease
R270	T2487	T2485	pobj	disease,to
R271	T2488	T2480	punct	.,shown
R272	T2490	T2491	nsubj	Most,reach
R273	T2492	T2490	prep	of,Most
R274	T2493	T2494	det	these,regions
R277	T2496	T2491	aux	did,reach
R278	T2497	T2491	neg	not,reach
R279	T2498	T2499	det	a,value
R282	T2501	T2499	amod	wide,value
R286	T2505	T2499	prep	of,value
R287	T2506	T2505	pobj	linkage,of
R288	T2507	T2499	punct	", ",value
R289	T2508	T2499	prep	with,value
R290	T2509	T2510	compound	P,values
R291	T2510	T2508	pobj	values,with
R292	T2511	T2510	prep	between,values
R293	T2512	T2511	pobj	0.05,between
R294	T2513	T2512	cc	and,0.05
R295	T2514	T2512	conj	0.001,0.05
R296	T2515	T2516	punct	[,1
R297	T2516	T2491	parataxis	1,reach
R298	T2517	T2518	punct	-,5
R299	T2518	T2516	prep	5,1
R300	T2519	T2516	punct	],1
R301	T2520	T2491	punct	.,reach
R302	T2522	T2523	advmod	Thus,have
R303	T2524	T2523	punct	", ",have
R304	T2525	T2526	det	these,loci
R305	T2526	T2523	nsubj	loci,have
R306	T2527	T2523	advmod	only,have
R307	T2528	T2529	det	a,effect
R310	T2531	T2529	prep	on,effect
R311	T2532	T2531	pobj	RA,on
R312	T2533	T2523	punct	.,have
R313	T2535	T2536	amod	Small,contributions
R316	T2539	T2538	aux	could,seen
R317	T2540	T2538	advmod	also,seen
R318	T2541	T2538	auxpass	be,seen
R319	T2542	T2538	prep	from,seen
R320	T2543	T2544	det	the,genes
R323	T2546	T2544	prep	of,genes
R324	T2547	T2546	pobj	RA,of
R325	T2548	T2544	acl	identified,genes
R326	T2549	T2550	advmod	so,far
R327	T2550	T2548	advmod	far,identified
R328	T2551	T2544	punct	", ",genes
R329	T2552	T2544	prep	including,genes
R330	T2553	T2554	compound	HLA,DR4
R333	T2556	T2554	punct	", ",DR4
R334	T2557	T2554	conj	PADI4,DR4
R335	T2558	T2557	punct	", ",PADI4
R336	T2559	T2557	conj	PTPN22,PADI4
R337	T2560	T2559	cc	and,PTPN22
R338	T2561	T2559	conj	FCRL3,PTPN22
R339	T2562	T2563	punct	[,6
R340	T2563	T2538	parataxis	6,seen
R341	T2564	T2565	punct	-,9
R342	T2565	T2563	prep	9,6
R343	T2566	T2563	punct	],6
R344	T2567	T2538	punct	.,seen
R345	T2569	T2570	prep	Except,have
R346	T2571	T2569	prep	for,Except
R347	T2572	T2573	compound	HLA,DR4
R350	T2575	T2573	punct	", ",DR4
R351	T2576	T2577	dep	which,associated
R355	T2580	T2577	prep	with,associated
R356	T2581	T2580	pobj	RA,with
R357	T2582	T2570	punct	", ",have
R358	T2583	T2584	predet	all,genes
R363	T2588	T2589	advmod	only,effect
R367	T2592	T2589	prep	on,effect
R368	T2593	T2594	det	the,disease
R570	T2812	T2813	amod	quantitative,trait
R571	T2813	T2811	compound	trait,genes
R573	T2814	T2811	punct	(,genes
R574	T2815	T2811	appos	QTGs,genes
R575	T2816	T2811	punct	),genes
R576	T2817	T2811	prep	in,genes
R577	T2818	T2819	det	the,genome
R644	T2890	T2885	mark	that,affect
R930	T3195	T3171	auxpass	were,generated
R931	T3196	T3171	cc	and,generated
R932	T3197	T3198	det	a,analysis
R935	T3200	T3198	amod	wide,analysis
R940	T3205	T3206	aux	to,identify
R941	T3206	T3203	advcl	identify,performed
R942	T3207	T3208	amod	small,effect
R945	T3210	T3206	dobj	QTL,identify
R946	T3211	T3203	punct	.,performed
R947	T3213	T3214	prep	At,detected
R948	T3215	T3216	det	the,level
R951	T3218	T3214	punct	", ",detected
R952	T3219	T3214	nsubj	we,detected
R953	T3220	T3221	det	the,patterns
R957	T3224	T3221	prep	of,patterns
R958	T3225	T3226	preconj	both,strains
R966	T3233	T3228	conj	N,DBA
R968	T3235	T3214	prep	at,detected
R969	T3236	T3237	nummod	four,phases
R972	T3239	T3237	prep	of,phases
R973	T3240	T3239	pobj	CIA,of
R974	T3241	T3214	punct	.,detected
R975	T3243	T3244	det	The,genes
R981	T3250	T3247	prep	based,identified
R982	T3251	T3250	prep	on,based
R983	T3252	T3253	nummod	three,criteria
R984	T3253	T3251	pobj	criteria,on
R985	T3254	T3249	punct	: ,located
R986	T3255	T3249	nsubjpass	they,located
R987	T3256	T3249	auxpass	are,located
R988	T3257	T3249	prep	within,located
R989	T3258	T3259	det	the,region
R992	T3261	T3259	acl	linked,region
R993	T3262	T3261	prep	to,linked
R994	T3263	T3262	pobj	CIA,to
R995	T3264	T3249	punct	;,located
R996	T3265	T3266	nsubjpass	they,expressed
R1000	T3269	T3266	advmod	specific,expressed
R1003	T3272	T3266	prep	during,expressed
R1004	T3273	T3272	pobj	CIA,during
R1005	T3274	T3266	punct	;,expressed
R1006	T3275	T3266	cc	and,expressed
R1007	T3276	T3277	nsubjpass	they,expressed
R1011	T3280	T3277	advmod	specific,expressed
R1014	T3283	T3277	prep	between,expressed
R1015	T3284	T3285	det	the,strains
R1019	T3288	T3277	prep	during,expressed
R1020	T3289	T3288	pobj	CIA,during
R1021	T3290	T3249	punct	.,located
R4108	T14127	T14125	prep	between,difference
R4111	T14129	T14127	pobj	strains,between
R4482	T14529	T14530	advmod	previously,identified
R4483	T14530	T14528	amod	identified,QTL
R4486	T14532	T14511	punct	.,identified
R4478	T14526	T14524	prep	with,overlap
R4479	T14527	T14528	det	any,QTL
R4481	T14528	T14526	pobj	QTL,with
R4485	T14531	T14528	compound	arthritis,QTL
R4488	T14534	T14535	prep	On,result
R4489	T14536	T14537	det	the,level
R4491	T14537	T14534	pobj	level,On
R4492	T14538	T14537	compound	transcriptome,level

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T2321	56-66	GO:0065007	denotes	controlled
T2322	75-80	SO_EXT:0000704	denotes	genes
T2323	203-209	UBERON:0002405	denotes	immune
T2324	271-278	SO_EXT:0000704	denotes	genetic
T2325	309-316	SO_EXT:0001026	denotes	genomic
T2326	386-393	SO_EXT:0001026	denotes	genomic
T2327	418-424	SO_EXT:0001026	denotes	genome
T2328	569-576	SO_EXT:0000704	denotes	genetic
T2329	634-639	SO_EXT:0000704	denotes	genes
T2330	675-682	PR_EXT:000002021	denotes	HLA-DR4
T2331	684-689	PR_EXT:000012222	denotes	PADI4
T2332	691-697	PR_EXT:000013457	denotes	PTPN22
T2333	702-707	PR_EXT:000007442	denotes	FCRL3
T2334	726-733	PR_EXT:000002021	denotes	HLA-DR4
T2335	802-807	SO_EXT:0000704	denotes	genes
T2336	856-861	NCBITaxon:10088	denotes	mouse
T2337	881-888	SO_EXT:0000704	denotes	genetic
T2338	979-985	SO_EXT:0001026	denotes	genome
T2339	1009-1032	SO_EXT:0000771	denotes	quantitative trait loci
T2340	1034-1037	SO_EXT:0000771	denotes	QTL
T2341	1042-1050	CHEBI_PR_EXT:collagen	denotes	collagen
T2342	1099-1105	NCBITaxon:33208	denotes	animal
T2343	1128-1131	SO_EXT:0000771	denotes	QTL
T2344	1198-1201	SO_EXT:0000771	denotes	QTL
T2345	1351-1356	SO_EXT:0000704	denotes	genes
T2346	1487-1493	NCBITaxon:33208	denotes	animal
T2347	1539-1546	SO_EXT:0000704	denotes	genetic
T2348	1633-1640	SO_EXT:0000704	denotes	genetic
T2349	1653-1659	NCBITaxon:33208	denotes	animal
T2350	1715-1720	SO_EXT:0000704	denotes	genes
T2351	1813-1816	SO_EXT:0000771	denotes	QTL
T2352	1845-1850	NCBITaxon:10088	denotes	mouse
T2353	1851-1857	SO_EXT:0001026	denotes	genome
T2354	1874-1877	SO_EXT:0000771	denotes	QTL
T2355	1974-1979	SO_EXT:0000704	denotes	genes
T2356	1994-1999	NCBITaxon:10088	denotes	mouse
T2357	2000-2006	SO_EXT:0001026	denotes	genome
T2358	2075-2081	NCBITaxon:33208	denotes	animal
T2359	2105-2118	SO_EXT:polymorphism	denotes	polymorphisms
T2360	2126-2133	CHEBI_PR_EXT:protein	denotes	protein
T2361	2126-2140	SO:0000010	denotes	protein-coding
T2362	2134-2147	SO_EXT:coding_sequence	denotes	coding region
T2363	2168-2175	CHEBI_PR_EXT:protein	denotes	protein
T2364	2197-2204	CHEBI_PR_EXT:protein	denotes	protein
T2365	2267-2270	SO_EXT:0000771	denotes	QTL
T2366	2358-2371	SO_EXT:polymorphism	denotes	polymorphisms
T2367	2372-2382	GO:0065007	denotes	regulating
T2368	2383-2387	SO_EXT:0000704	denotes	gene
T2369	2383-2398	GO:0010467	denotes	gene expression
T2370	2516-2520	SO_EXT:0000704	denotes	gene
T2371	2516-2531	GO:0010467	denotes	gene expression
T2372	2620-2625	SO_EXT:0000704	denotes	genes
T2373	2682-2691	GO:0065007	denotes	regulated
T2374	2714-2719	SO_EXT:0000704	denotes	genes
T2375	2773-2783	GO:0010467	denotes	expression
T2376	2816-2821	CL_GO_EXT:cell	denotes	cells
T2377	2822-2829	UBERON:0000479	denotes	tissues
T2378	2937-2943	NCBITaxon:33208	denotes	animal
T2379	2968-2973	SO_EXT:0000704	denotes	genes
T2380	3010-3020	GO:0010467	denotes	expression
T2381	3041-3048	UBERON:0000479	denotes	tissues
T2382	3089-3094	SO_EXT:0000704	denotes	Genes
T2383	3107-3135	GO:0002437	denotes	immunoinflammatory responses
T2384	3156-3165	GO:0010467	denotes	expressed
T2385	3173-3178	UBERON:0000178	denotes	blood
T2386	3173-3184	CL:0000081	denotes	blood cells
T2387	3179-3184	CL_GO_EXT:cell	denotes	cells
T2388	3206-3216	GO_EXT:0008009	denotes	Chemokines
T2389	3221-3229	GO_PATO_EXT:biological_adhesion_entity_or_process	denotes	adhesion
T2390	3230-3239	CHEBI:36357	denotes	molecules
T2391	3245-3256	GO_EXT:positive_regulation	denotes	upregulated
T2392	3264-3269	UBERON:0004905	denotes	joint
T2393	3310-3316	NCBITaxon:33208	denotes	animal
T2394	3339-3344	SO_EXT:0000704	denotes	genes
T2395	3357-3366	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T2396	3383-3387	UBERON_EXT:bone_element_or_tissue	denotes	bone
T2397	3416-3425	GO:0010467	denotes	expressed
T2398	3460-3466	NCBITaxon:33208	denotes	animal
T2399	3507-3512	SO_EXT:0000704	denotes	genes
T2400	3588-3595	SO_EXT:0000704	denotes	genetic
T2401	3596-3609	SO_EXT:polymorphism	denotes	polymorphisms
T2402	3610-3620	GO:0065007	denotes	regulating
T2403	3621-3625	SO_EXT:0000704	denotes	gene
T2404	3621-3636	GO:0010467	denotes	gene expression
T2405	3658-3669	GO:0010467	denotes	expressions
T2406	3715-3727	SO_EXT:polymorphism	denotes	polymorphism
T2407	3739-3749	GO:0065007	denotes	regulatory
T2408	3739-3758	SO_EXT:0005836	denotes	regulatory elements
T2409	3789-3792	SO_EXT:0000771	denotes	QTL
T2410	3835-3840	SO_EXT:0000704	denotes	genes
T2411	3874-3885	SO_EXT:0000704	denotes	genetically
T2412	3932-3938	SO_EXT:0001026	denotes	genome
T2413	3972-3978	SO_EXT:0001026	denotes	genome
T2414	4079-4085	SO_EXT:0001026	denotes	genome
T2415	4147-4150	SO_EXT:0000771	denotes	QTL
T2416	4196-4200	SO_EXT:0000704	denotes	gene
T2417	4196-4211	GO:0010467	denotes	gene expression
T2418	4314-4319	SO_EXT:0000704	denotes	genes
T2419	4389-4396	SO_EXT:0001026	denotes	genomic
T2420	4460-4469	GO:0010467	denotes	expressed
T2421	4526-4535	GO:0010467	denotes	expressed
T4014	4605-4612	NCBITaxon:33208	denotes	Animals
T4015	4676-4680	NCBITaxon:10088	denotes	mice
T4016	4825-4831	NCBITaxon:33208	denotes	animal
T4017	4875-4881	NCBITaxon:33208	denotes	animal
T4018	4925-4931	NCBITaxon:33208	denotes	Animal
T4019	4992-4999	NCBITaxon:33208	denotes	animals
T4020	5168-5172	UBERON:0002415	denotes	tail
T4021	5188-5194	NCBITaxon:27592	denotes	bovine
T4022	5195-5203	CHEBI_PR_EXT:collagen	denotes	Collagen
T4023	5195-5206	PR_EXT:000003266	denotes	Collagen II
T4024	5357-5364	NCBITaxon:33208	denotes	animals
T4025	5465-5470	UBERON:0002101	denotes	limbs
T4026	5502-5506	UBERON:0002101	denotes	limb
T4027	5569-5573	NCBITaxon:10088	denotes	mice
T4028	5605-5609	SO_EXT:0000704	denotes	gene
T4029	5605-5620	GO:0010467	denotes	gene expression
T4030	5862-5866	NCBITaxon:10088	denotes	mice
T4031	5877-5887	GO_EXT:killing	denotes	sacrificed
T4032	5915-5919	NCBITaxon:10088	denotes	mice
T4033	5941-5951	GO_EXT:killing	denotes	sacrificed
T4034	5986-5990	NCBITaxon:10088	denotes	mice
T4035	6012-6022	GO_EXT:killing	denotes	sacrificed
T4036	6079-6083	NCBITaxon:10088	denotes	mice
T4037	6100-6104	NCBITaxon:10088	denotes	mice
T4038	6176-6186	GO_EXT:killing	denotes	sacrificed
T4039	6221-6225	NCBITaxon:10088	denotes	mice
T4040	6247-6257	GO_EXT:killing	denotes	sacrificed
T4041	6314-6318	NCBITaxon:10088	denotes	mice
T4042	6335-6339	NCBITaxon:10088	denotes	mice
T4043	6398-6408	GO_EXT:killing	denotes	sacrificed
T4621	6499-6505	SO_EXT:0001026	denotes	genome
T4622	6579-6583	NCBITaxon:10088	denotes	mice
T4623	6606-6620	SO_EXT:microsatellite_unit_or_region	denotes	microsatellite
T4624	6621-6628	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4625	6642-6648	SO_EXT:0001026	denotes	genome
T4626	6671-6677	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T4627	6897-6900	SO_EXT:0000771	denotes	QTL
T4986	7034-7037	UBERON:0000029	denotes	LNs
T4987	7090-7093	CHEBI_SO_EXT:RNA	denotes	RNA
T4984	7007-7020	GO:0097617	denotes	hybridisation
T4985	7021-7032	UBERON:0000029	denotes	Lymph nodes
T4988	7117-7120	CHEBI_SO_EXT:RNA	denotes	RNA
T4989	7144-7150	UBERON:0000479	denotes	tissue
T4990	7265-7269	SO_EXT:0000704	denotes	gene
T4991	7265-7280	GO:0010467	denotes	gene expression
T4992	7381-7386	SO_EXT:0000704	denotes	genes
T4993	7388-7398	CHEBI_SO_EXT:riboprobe	denotes	RNA probes
T4994	7404-7412	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T4995	7489-7493	NCBITaxon:10088	denotes	mice
T4996	7499-7509	GO:0097617	denotes	hybridised
T4997	7534-7547	GO:0097617	denotes	Hybridisation
T4998	7563-7567	SO_EXT:0000704	denotes	gene
T4999	7680-7684	SO_EXT:0000704	denotes	Gene
T5584	7737-7747	GO:0010467	denotes	expression
T5585	7838-7842	SO_EXT:0000704	denotes	gene
T5586	7838-7853	GO:0010467	denotes	gene expression
T5587	7891-7901	GO:0010467	denotes	expression
T5588	7969-7978	GO:0010467	denotes	expressed
T5589	7979-7984	SO_EXT:0000704	denotes	genes
T5590	8416-8421	SO_EXT:0000704	denotes	genes
T5591	8436-8440	SO_EXT:0000704	denotes	gene
T5592	8497-8501	SO_EXT:0000704	denotes	gene
T5593	8497-8512	GO:0010467	denotes	gene expression
T5594	8570-8575	SO_EXT:0000704	denotes	genes
T5595	8617-8622	SO_EXT:0000704	denotes	genes
T5596	8716-8726	GO:0010467	denotes	expression
T5597	8745-8750	SO_EXT:0000704	denotes	genes
T5598	8843-8852	GO:0010467	denotes	expressed
T5599	8853-8858	SO_EXT:0000704	denotes	genes
T5600	8860-8864	SO_EXT:0000704	denotes	Gene
T5601	8915-8918	CHEBI_SO_EXT:DNA	denotes	DNA
T5602	9059-9064	SO_EXT:0000704	denotes	genes
T7051	10849-10856	SO_EXT:0001026	denotes	genomic
T7052	10898-10906	_FRAGMENT	denotes	syntenic
T7053	10915-10922	SO_EXT:0005858	denotes	regions
T7054	10907-10914	SO_EXT:0001026	denotes	genomic
T7055	10930-10935	NCBITaxon:9606	denotes	human
T7056	10936-10942	SO_EXT:0001026	denotes	genome
T7057	11004-11007	SO_EXT:0000771	denotes	QTL
T7058	11034-11037	SO_EXT:0000771	denotes	QTL
T7059	11045-11050	NCBITaxon:10088	denotes	mouse
T7060	11051-11057	SO_EXT:0001026	denotes	genome
T7026	9168-9174	SO_EXT:0001026	denotes	genome
T7027	9194-9197	SO_EXT:0000771	denotes	QTL
T7028	9198-9209	GO:0065007	denotes	controlling
T7029	9310-9313	SO_EXT:0000771	denotes	QTL
T7030	9526-9529	SO_EXT:0000771	denotes	QTL
T7031	9671-9674	SO_EXT:0000771	denotes	QTL
T7032	9794-9798	SO_EXT:0000704	denotes	gene
T7033	9808-9831	PR_EXT:000004904	denotes	complement component C5
T7034	9833-9835	PR_EXT:000004904	denotes	Hc
T7035	9917-9919	PR_EXT:000004904	denotes	C5
T7036	9957-9960	SO_EXT:0000771	denotes	QTL
T7037	10019-10021	PR_EXT:000004904	denotes	C5
T7038	10125-10127	PR_EXT:000004904	denotes	C5
T7039	10127-10128	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7040	10129-10130	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7041	10160-10162	PR_EXT:000004904	denotes	C5
T7042	10162-10163	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7043	10164-10165	SO_EXT:sequence_nullness_or_absence	denotes	-
T7044	10184-10191	SO_EXT:0001026	denotes	genomic
T7045	10341-10344	SO_EXT:0000771	denotes	QTL
T7046	10361-10372	GO_SO_EXT:chromosome	denotes	chromosomes
T7047	10510-10516	SO_EXT:0001023	denotes	allele
T7048	10560-10566	SO_EXT:0001023	denotes	allele
T7049	10757-10760	SO_EXT:0000771	denotes	QTL
T7050	10805-10808	SO_EXT:0000771	denotes	QTL
T7061	11131-11138	GO:0065007	denotes	control
T7062	11211-11221	GO_SO_EXT:chromosome	denotes	chromosome
T7063	11337-11345	GO:0065007	denotes	controls
T7064	11364-11376	CHEBI:37396	denotes	proteoglycan
T7065	11462-11470	_FRAGMENT	denotes	syntenic
T7066	11479-11486	SO_EXT:0005858	denotes	regions
T7067	11471-11478	SO_EXT:0001026	denotes	genomic
T7068	11508-11511	SO_EXT:0000771	denotes	QTL
T7069	11519-11524	NCBITaxon:9606	denotes	human
T7070	11525-11531	SO_EXT:0001026	denotes	genome
T7071	11581-11588	SO_EXT:0001026	denotes	genomic
T7072	11620-11630	GO_SO_EXT:chromosome	denotes	chromosome
T7073	11686-11696	GO_SO_EXT:chromosome	denotes	chromosome
T7074	11757-11767	GO_SO_EXT:chromosome	denotes	chromosome
T7075	11821-11831	GO_SO_EXT:chromosome	denotes	chromosome
T7076	11881-11891	GO_SO_EXT:chromosome	denotes	chromosome
T7077	11881-11893	GO_SO_EXT:chromosome	denotes	chromosome 3
T8286	11962-11971	GO:0010467	denotes	expressed
T8287	11972-11977	SO_EXT:0000704	denotes	genes
T8288	11994-11998	SO_EXT:0000704	denotes	gene
T8289	11994-12009	GO:0010467	denotes	gene expression
T8290	12031-12035	NCBITaxon:10088	denotes	mice
T8291	12220-12224	SO_EXT:0000704	denotes	gene
T8292	12268-12273	CHEBI_SO_EXT:molecular_probe	denotes	probe
T8293	12511-12520	GO:0010467	denotes	expressed
T8294	12521-12526	SO_EXT:0000704	denotes	genes
T8295	12556-12560	SO_EXT:0000704	denotes	gene
T8296	12556-12571	GO:0010467	denotes	gene expression
T8297	12678-12682	NCBITaxon:10088	denotes	mice
T8298	12709-12714	SO_EXT:0000704	denotes	genes
T8299	12735-12744	GO:0010467	denotes	expressed
T8300	12860-12865	SO_EXT:0000704	denotes	genes
T8301	12886-12895	GO:0010467	denotes	expressed
T8302	12909-12913	NCBITaxon:10088	denotes	mice
T8303	12955-12964	GO:0010467	denotes	expressed
T8304	12965-12970	SO_EXT:0000704	denotes	genes
T8305	13097-13106	GO:0010467	denotes	expressed
T8306	13107-13112	SO_EXT:0000704	denotes	genes
T8307	13160-13165	SO_EXT:0000704	denotes	genes
T8308	13185-13190	SO_EXT:0000704	denotes	genes
T8309	13239-13244	SO_EXT:0000704	denotes	genes
T8310	13278-13288	GO:0010467	denotes	expression
T8311	13345-13350	SO_EXT:0000704	denotes	genes
T8312	13370-13375	SO_EXT:0000704	denotes	genes
T8313	13412-13421	GO:0010467	denotes	expressed
T9495	14109-14114	SO_EXT:0000704	denotes	genes
T9496	14125-14129	SO_EXT:0000704	denotes	gene
T9497	14149-14158	GO:0010467	denotes	expressed
T9498	14200-14204	SO_EXT:0000704	denotes	gene
T9499	14239-14248	GO:0010467	denotes	expressed
T9500	14249-14254	SO_EXT:0000704	denotes	genes
T9480	13522-13531	GO:0010467	denotes	expressed
T9481	13532-13537	SO_EXT:0000704	denotes	genes
T9482	13586-13595	GO:0010467	denotes	expressed
T9483	13596-13601	SO_EXT:0000704	denotes	genes
T9484	13626-13631	SO_EXT:0000704	denotes	genes
T9485	13657-13666	GO:0010467	denotes	expressed
T9486	13670-13673	UBERON:0000029	denotes	LNs
T9487	13825-13830	SO_EXT:0000704	denotes	genes
T9488	13851-13860	GO:0010467	denotes	expressed
T9489	13881-13892	GO_EXT:positive_regulation	denotes	upregulated
T9490	13960-13965	SO_EXT:0000704	denotes	genes
T9491	13986-13995	GO:0010467	denotes	expressed
T9492	14053-14062	GO:0010467	denotes	expressed
T9493	14063-14068	SO_EXT:0000704	denotes	genes
T9494	14095-14108	GO_EXT:negative_regulation	denotes	downregulated
T9501	14387-14396	GO:0010467	denotes	expressed
T9502	14397-14402	SO_EXT:0000704	denotes	genes
T9503	14423-14432	GO:0065007	denotes	regulated
T9504	14453-14457	NCBITaxon:10088	denotes	mice
T9505	14507-14511	SO_EXT:0000704	denotes	gene
T9506	14507-14522	GO:0010467	denotes	gene expression
T9507	14600-14605	SO_EXT:0000704	denotes	genes
T9508	14611-14615	SO_EXT:0000704	denotes	gene
T9509	14693-14697	SO_EXT:0000704	denotes	gene
T9510	14693-14708	GO:0010467	denotes	gene expression
T9511	14751-14756	SO_EXT:0000704	denotes	genes
T9512	14771-14776	SO_EXT:0000704	denotes	genes
T9513	14787-14798	GO_EXT:positive_regulation	denotes	upregulated
T9514	14827-14837	GO:0010467	denotes	expression
T9515	14847-14852	SO_EXT:0000704	denotes	genes
T9516	14974-14980	UBERON:0002405	denotes	immune
T9517	14974-14989	GO:0006955	denotes	immune response
T9518	15014-15019	SO_EXT:0000704	denotes	genes
T9519	15026-15036	GO:0010467	denotes	expression
T9520	15051-15062	GO_EXT:positive_regulation	denotes	upregulated
T9521	15117-15122	SO_EXT:0000704	denotes	genes
T9522	15149-15155	UBERON:0002405	denotes	immune
T9523	15149-15164	GO:0006955	denotes	immune response
T9524	15166-15184	GO:0031090	denotes	organelle membrane
T9525	15189-15209	GO:0005576	denotes	extracellular region
T9526	15189-15202	_FRAGMENT	denotes	extracellular
T9527	15214-15219	GO:0005615	denotes	space
T9528	15194-15202	CL_GO_EXT:cell	denotes	cellular
T9529	15245-15250	SO_EXT:0000704	denotes	genes
T9530	15266-15277	GO_EXT:positive_regulation	denotes	upregulated
T9531	15301-15306	SO_EXT:0000704	denotes	genes
T9532	15326-15348	GO:0005911	denotes	intercellular junction
T9533	15331-15339	CL_GO_EXT:cell	denotes	cellular
T9534	15372-15377	SO_EXT:0000704	denotes	genes
T9535	15426-15431	SO_EXT:0000704	denotes	genes
T9536	15445-15458	GO_EXT:negative_regulation	denotes	downregultaed
T9537	15487-15492	SO_EXT:0000704	denotes	genes
T9538	15521-15531	CL:0000542	denotes	lymphocyte
T9539	15521-15545	GO:0046651	denotes	lymphocyte proliferation
T9540	15547-15553	CL:0000084	denotes	T cell
T9541	15547-15564	GO:0042110	denotes	T cell activation
T9542	15549-15553	CL_GO_EXT:cell	denotes	cell
T9543	15566-15573	CHEBI_PR_EXT:protein	denotes	protein
T9544	15574-15581	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9545	15597-15602	PR_EXT:Notch	denotes	notch
T9546	15597-15617	GO:0007219	denotes	notch signal pathway
T9547	15644-15649	SO_EXT:0000704	denotes	genes
T9548	15650-15663	GO_EXT:negative_regulation	denotes	downregulated
T9549	15704-15709	SO_EXT:0000704	denotes	genes
T9550	15710-15723	GO_EXT:negative_regulation	denotes	downregulated
T9551	15842-15846	SO_EXT:0000704	denotes	gene
T10760	17146-17151	SO_EXT:0000704	denotes	genes
T10761	17172-17181	GO:0010467	denotes	expressed
T10762	17214-17220	PR_EXT:000008409	denotes	H2-Q10
T10763	17222-17228	PR_EXT:000003107	denotes	Mapk14
T10764	17230-17235	PR_EXT:000006153	denotes	Pscd1
T10765	17237-17242	PR_EXT:000009439	denotes	Kpnb1
T10730	15868-15873	SO_EXT:0000704	denotes	genes
T10731	15895-15898	SO_EXT:0000771	denotes	QTL
T10732	15974-15977	SO_EXT:0000771	denotes	QTL
T10733	16034-16043	GO:0010467	denotes	expressed
T10734	16044-16049	SO_EXT:0000704	denotes	genes
T10735	16099-16108	GO:0010467	denotes	expressed
T10736	16109-16114	SO_EXT:0000704	denotes	genes
T10737	16120-16125	SO_EXT:0000704	denotes	genes
T10738	16214-16219	SO_EXT:0000704	denotes	genes
T10739	16282-16285	SO_EXT:0000771	denotes	QTL
T10740	16320-16331	GO_SO_EXT:chromosome	denotes	chromosomes
T10741	16395-16398	SO_EXT:0000771	denotes	QTL
T10742	16448-16449	CHEBI_SO_EXT:base	denotes	b
T10743	16503-16508	SO_EXT:0000704	denotes	genes
T10744	16570-16573	SO_EXT:0000771	denotes	QTL
T10745	16626-16631	SO_EXT:0000704	denotes	genes
T10746	16726-16730	SO_EXT:0000704	denotes	gene
T10747	16800-16805	SO_EXT:0000704	denotes	genes
T10748	16836-16841	SO_EXT:0000704	denotes	genes
T10749	16843-16849	PR_EXT:000008871	denotes	hspa1a
T10750	16854-16859	PR_EXT:000012101	denotes	Oas1a
T10751	16866-16877	GO_EXT:positive_regulation	denotes	upregulated
T10752	16905-16910	PR_EXT:000012101	denotes	Oas1a
T10753	16920-16931	GO_EXT:positive_regulation	denotes	upregulated
T10754	16970-16975	SO_EXT:0000704	denotes	genes
T10755	16990-16995	SO_EXT:0000704	denotes	genes
T10756	17001-17014	GO_EXT:negative_regulation	denotes	downregulated
T10757	17048-17053	SO_EXT:0000704	denotes	genes
T10758	17062-17068	PR_EXT:000008871	denotes	hspa1a
T10759	17077-17087	GO:0010467	denotes	expression
T10766	17247-17251	PR_EXT:000017387	denotes	Wdr1
T10767	17270-17275	SO_EXT:0000704	denotes	genes
T10768	17277-17283	PR_EXT:000008409	denotes	H2-Q10
T10769	17310-17320	GO:0010467	denotes	expression
T10770	17396-17401	SO_EXT:0000704	denotes	genes
T10771	17415-17425	GO:0010467	denotes	expression
T10772	17504-17514	GO:0010467	denotes	expression
T10773	17609-17616	CHEBI_PR_EXT:protein	denotes	protein
T10774	17609-17623	GO_EXT:0004672	denotes	protein kinase
T10775	17679-17684	SO_EXT:0000704	denotes	genes
T10776	17725-17730	SO_EXT:0000704	denotes	genes
T10777	17742-17748	PR_EXT:000003107	denotes	Mapk14
T10778	17750-17758	PR_EXT:000010162	denotes	Mapk8ip3
T10779	17760-17766	PR_EXT:000002091	denotes	Stat5a
T10780	17771-17776	PR_EXT:000008081	denotes	Gna12
T13321	17862-17865	SO_EXT:0000771	denotes	QTL
T13322	17897-17900	SO_EXT:0000771	denotes	QTL
T13323	18137-18140	SO_EXT:0000771	denotes	QTL
T13324	18171-18176	SO_EXT:0000704	denotes	genes
T13325	18278-18280	PR_EXT:000004904	denotes	C5
T13326	18280-18281	SO_EXT:normal_or_wild_type_or_present	denotes	+
T13327	18282-18283	SO_EXT:normal_or_wild_type_or_present	denotes	+
T13328	18303-18305	PR_EXT:000004904	denotes	C5
T13329	18305-18306	SO_EXT:normal_or_wild_type_or_present	denotes	+
T13330	18307-18308	SO_EXT:sequence_nullness_or_absence	denotes	-
T13331	18352-18355	SO_EXT:0000771	denotes	QTL
T13332	18420-18423	SO_EXT:0000771	denotes	QTL
T13333	18455-18458	SO_EXT:0000771	denotes	QTL
T13334	18514-18517	SO_EXT:0000771	denotes	QTL
T13335	18584-18592	SO:0000860	denotes	syntenic
T13336	18632-18639	SO_EXT:0001026	denotes	genomic
T13337	18655-18660	NCBITaxon:9606	denotes	human
T13338	18661-18667	SO_EXT:0001026	denotes	genome
T13339	18691-18694	SO_EXT:0000771	denotes	QTL
T13340	18748-18751	SO_EXT:0000771	denotes	QTL
T13341	18762-18769	SO_EXT:0001023	denotes	alleles
T13342	18798-18805	SO_EXT:0001023	denotes	alleles
T13343	18822-18829	SO_EXT:0001023	denotes	alleles
T13344	18858-18865	SO_EXT:0001023	denotes	alleles
T13345	18885-18888	SO_EXT:0000771	denotes	QTL
T13346	18926-18931	SO_EXT:0000704	denotes	genes
T13347	19043-19046	SO_EXT:0000771	denotes	QTL
T13348	19125-19132	SO_EXT:0001026	denotes	genomic
T13349	19152-19155	SO_EXT:0000771	denotes	QTL
T13350	19156-19167	GO:0065007	denotes	controlling
T13351	19174-19182	GO:0042571	denotes	antibody
T13352	19193-19201	CHEBI_PR_EXT:collagen	denotes	collagen
T13353	19193-19204	PR_EXT:000003266	denotes	collagen II
T13354	19237-19240	SO_EXT:0000771	denotes	QTL
T13355	19253-19254	CHEBI_SO_EXT:base	denotes	b
T13356	19255-19262	SO_EXT:0001026	denotes	genomic
T13357	19288-19292	SO_EXT:0000704	denotes	gene
T13358	19312-19321	GO:0065007	denotes	regulates
T13359	19338-19349	GO:0065007	denotes	controlling
T13360	19360-19368	GO:0042571	denotes	antibody
T13361	19379-19387	CHEBI_PR_EXT:collagen	denotes	collagen
T13362	19379-19390	PR_EXT:000003266	denotes	collagen II
T13363	19397-19402	_FRAGMENT	denotes	Locus
T13364	19405-19418	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	on chromosome
T13365	19447-19455	GO:0065007	denotes	controls
T13366	19456-19466	CL:0000542	denotes	lymphocyte
T13367	19456-19480	GO:0046651	denotes	lymphocyte proliferation
T13368	19530-19534	_FRAGMENT	denotes	loci
T13369	19537-19550	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	on chromosome
T13370	19554-19562	GO:0065007	denotes	controls
T13371	19563-19573	CL:0000542	denotes	lymphocyte
T13372	19626-19630	SO_EXT:0000704	denotes	gene
T13373	19655-19658	SO_EXT:0000771	denotes	QTL
T13374	19693-19704	GO:0065007	denotes	controlling
T13375	19783-19787	SO_EXT:0000704	denotes	gene
T13376	19783-19798	GO:0010467	denotes	gene expression
T13377	19829-19835	UBERON:0004905	denotes	joints
T13378	19850-19856	UBERON:0000479	denotes	tissue
T13379	19913-19917	SO_EXT:0000704	denotes	gene
T13380	19913-19928	GO:0010467	denotes	gene expression
T13381	19932-19935	UBERON:0000029	denotes	LNs
T13382	19981-19985	SO_EXT:0000704	denotes	gene
T13383	19981-19996	GO:0010467	denotes	gene expression
T13384	20009-20012	UBERON:0000029	denotes	LNs
T13385	20021-20032	SO_EXT:0000704	denotes	genetically
T13386	20132-20141	GO:0065007	denotes	regulated
T13387	20142-20147	SO_EXT:0000704	denotes	genes
T13388	20225-20230	SO_EXT:0000704	denotes	genes
T13389	20251-20260	GO:0010467	denotes	expressed
T13390	20305-20315	CHEBI_GO_EXT:biological_process_or_quality_or_role	denotes	biological
T13391	20316-20325	GO_EXT:reaction_or_response	denotes	responses
T13392	20329-20332	UBERON:0000029	denotes	LNs
T13393	20401-20410	GO_EXT:reaction_or_response	denotes	responses
T13394	20554-20559	SO_EXT:0000704	denotes	genes
T13395	20590-20595	SO_EXT:0000704	denotes	genes
T13396	20609-20619	GO:0010467	denotes	expression
T13397	20703-20713	GO:0010467	denotes	expression
T13398	20782-20787	SO_EXT:0000704	denotes	genes
T13399	20804-20814	CL:0000542	denotes	lymphocyte
T13400	20804-20828	GO:0046651	denotes	lymphocyte proliferation
T13401	20804-20814	_FRAGMENT	denotes	lymphocyte
T13402	20833-20843	GO:0046649	denotes	activation
T13403	20861-20872	CL:0000542	denotes	lymphocytes
T13404	21001-21011	GO:0010467	denotes	expression
T13405	21058-21062	NCBITaxon:10088	denotes	mice
T13406	21104-21109	SO_EXT:0000704	denotes	genes
T13407	21125-21131	UBERON:0002405	denotes	immune
T13408	21125-21140	GO:0006955	denotes	immune response
T13409	21146-21157	GO_EXT:positive_regulation	denotes	upregulated
T13410	21263-21271	GO:0042571	denotes	antibody
T13411	21263-21280	GO:0016064	denotes	antibody response
T13412	21284-21292	CHEBI_PR_EXT:collagen	denotes	collagen
T13413	21284-21295	PR_EXT:000003266	denotes	collagen II
T13414	21460-21465	SO_EXT:0000704	denotes	genes
T13415	21505-21510	SO_EXT:0000704	denotes	genes
T13416	21545-21548	SO_EXT:0000771	denotes	QTL
T13417	21568-21572	SO_EXT:0000704	denotes	gene
T13418	21568-21583	GO:0010467	denotes	gene expression
T13419	21614-21621	SO_EXT:0001026	denotes	genomic
T13420	21646-21651	SO_EXT:0000704	denotes	genes
T13421	21668-21671	SO_EXT:0000771	denotes	QTL
T13422	21701-21714	SO_EXT:polymorphism	denotes	polymorphisms
T13423	21737-21742	SO_EXT:0000704	denotes	genes
T13424	21760-21763	SO_EXT:0000771	denotes	QTL
T13425	21798-21808	GO:0065007	denotes	regulating
T13426	21809-21813	SO_EXT:0000704	denotes	gene
T13427	21809-21824	GO:0010467	denotes	gene expression
T13428	21850-21855	SO_EXT:0000704	denotes	genes
T13429	21899-21905	PR_EXT:000003107	denotes	Mapk14
T13430	21919-21923	SO_EXT:0000704	denotes	gene
T13431	21952-21988	_FRAGMENT	denotes	p38 mitogen-activated protein kinase
T13432	21996-22001	PR_EXT:000003107	denotes	alpha
T13433	21952-21955	_FRAGMENT	denotes	p38
T13434	21990-21994	_FRAGMENT	denotes	MAPK
T13435	21956-21963	CHEBI_EXT:52290	denotes	mitogen
T13436	21956-21988	GO_PR_EXT:MAP_kinase	denotes	mitogen-activated protein kinase
T13437	21974-21981	CHEBI_PR_EXT:protein	denotes	protein
T13438	21990-21994	GO_PR_EXT:MAP_kinase	denotes	MAPK
T13439	22003-22012	GO:0065007	denotes	regulates
T13440	22017-22030	_FRAGMENT	denotes	production of
T13441	22051-22060	GO_EXT:cytokine_biosynthesis_or_production	denotes	cytokines
T13442	22051-22060	GO_EXT:0005125	denotes	cytokines
T13443	22070-22092	PR_EXT:tumor_necrosis_factor	denotes	tumour necrosis factor
T13444	22077-22085	GO_PATO_EXT:necrosis	denotes	necrosis
T13445	22097-22110	PR_EXT:000001091	denotes	interleukin-1
T13446	22127-22140	_FRAGMENT	denotes	inhibitors of
T13447	22145-22149	CHEBI_EXT:79091	denotes	MAPK
T13448	22141-22149	PR_EXT:000003106	denotes	p38 MAPK
T13449	22145-22149	GO_PR_EXT:MAP_kinase	denotes	MAPK
T14915	24030-24035	SO_EXT:0000704	denotes	genes
T14904	23574-23579	SO_EXT:0000704	denotes	genes
T14905	23597-23600	SO_EXT:0000771	denotes	QTL
T14906	23649-23654	SO_EXT:0000704	denotes	genes
T14907	23674-23677	SO_EXT:0000771	denotes	QTL
T14908	23678-23688	GO:0065007	denotes	regulating
T14909	23803-23810	NCBITaxon:33208	denotes	animals
T14910	23838-23841	SO_EXT:0000771	denotes	QTL
T14911	23926-23929	SO_EXT:0000771	denotes	QTL
T14912	23978-23983	SO_EXT:0000704	denotes	genes
T14913	23995-24000	NCBITaxon:10088	denotes	mouse
T14914	24005-24010	NCBITaxon:9606	denotes	human
T14916	24085-24097	SO_EXT:polymorphism	denotes	polymorphism
T14917	24162-24166	NCBITaxon:10088	denotes	mice
T14918	24198-24203	SO_EXT:0000704	denotes	genes
T14919	24251-24256	NCBITaxon:9606	denotes	human
T14920	24257-24263	SO_EXT:0001026	denotes	genome
T14921	24316-24321	SO_EXT:0000704	denotes	genes
T13475	23219-23234	GO:0010467	denotes	gene expression
T13476	23294-23303	GO:0010467	denotes	expressed
T13477	23304-23309	SO_EXT:0000704	denotes	genes
T13478	23341-23351	GO:0010467	denotes	expression
T13479	23357-23361	SO_EXT:0000704	denotes	gene
T13480	23389-23395	SO_EXT:0001023	denotes	allele
T7025	9089-9092	SO_EXT:0000771	denotes	QTL
T13450	22173-22177	NCBITaxon:10114	denotes	rats
T13451	22188-22196	PR_EXT:000003106	denotes	p38 MAPK
T13452	22192-22196	GO_PR_EXT:MAP_kinase	denotes	MAPK
T13453	22252-22258	PR_EXT:000002091	denotes	Stat5a
T13454	22272-22276	SO_EXT:0000704	denotes	gene
T13455	22305-22313	CHEBI:36357	denotes	molecule
T13456	22318-22326	CL_UBERON_EXT:lymphocyte_or_lymphoid_progenitor_or_system_or_tissue	denotes	lymphoid
T13457	22343-22358	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T13458	22365-22371	PR_EXT:000002091	denotes	Stat5a
T13459	22382-22386	NCBITaxon:10088	denotes	mice
T13460	22456-22462	UBERON:0002405	denotes	immune
T13461	22473-22479	PR_EXT:000002091	denotes	Stat5a
T13462	22547-22550	PR_EXT:000001004	denotes	CD4
T13463	22551-22555	PR_EXT:000001380	denotes	CD25
T13464	22557-22567	GO:0065007	denotes	regulatory
T13465	22557-22574	CL:0000815	denotes	regulatory T cell
T13466	22570-22574	CL_GO_EXT:cell	denotes	cell
T13467	22657-22660	SO_EXT:0000771	denotes	QTL
T13468	22696-22701	SO_EXT:0000704	denotes	genes
T13469	22796-22803	NCBITaxon:33208	denotes	animals
T13470	22864-22870	SO_EXT:0001026	denotes	genome
T13471	22909-22912	SO_EXT:0000771	denotes	QTL
T13472	23111-23114	SO_EXT:0000771	denotes	QTL
T13473	23164-23171	NCBITaxon:33208	denotes	animals
T13474	23219-23223	SO_EXT:0000704	denotes	gene
R3522	T13434	T13433	_lexicallyChainedTo	MAPK,p38
R3523	T13441	T13440	_lexicallyChainedTo	cytokines,production of
R3524	T13447	T13446	_lexicallyChainedTo	MAPK,inhibitors of
R1822	T7053	T7052	_lexicallyChainedTo	regions,syntenic
R1823	T7066	T7065	_lexicallyChainedTo	regions,syntenic
R2723	T9527	T9526	_lexicallyChainedTo	space,extracellular
R3517	T13364	T13363	_lexicallyChainedTo	on chromosome,Locus
R3518	T13369	T13368	_lexicallyChainedTo	on chromosome,loci
R3519	T13402	T13401	_lexicallyChainedTo	activation,lymphocyte
R3520	T13432	T13431	_lexicallyChainedTo	alpha,p38 mitogen-activated protein kinase
R3521	T13432	T13434	_lexicallyChainedTo	alpha,MAPK

2_test

Id	Subject	Object	Predicate	Lexical cue
17244351-16691188-4361111	508-509	16691188	denotes	1
17244351-9724775-4361111	508-509	9724775	denotes	1
17244351-11254450-4361111	508-509	11254450	denotes	1
17244351-12687532-4361111	508-509	12687532	denotes	1
17244351-16278286-4361111	508-509	16278286	denotes	1
17244351-3059797-4361112	709-710	3059797	denotes	6
17244351-12833157-4361112	709-710	12833157	denotes	6
17244351-15838509-4361112	709-710	15838509	denotes	6
17244351-15208781-4361112	709-710	15208781	denotes	6
17244351-15529344-4361113	1292-1294	15529344	denotes	10
17244351-1675432-4361114	1924-1926	1675432	denotes	11
17244351-12089518-4361115	2028-2030	12089518	denotes	12
17244351-15803197-4361116	2031-2033	15803197	denotes	13
17244351-12493905-4361117	2149-2151	12493905	denotes	14
17244351-12482389-4361118	2952-2954	12482389	denotes	15
17244351-11908948-4361118	2952-2954	11908948	denotes	15
17244351-9122163-4361118	2952-2954	9122163	denotes	15
17244351-15158620-4361118	2952-2954	15158620	denotes	15
17244351-15496955-4361118	2952-2954	15496955	denotes	15
17244351-15973463-4361118	2952-2954	15973463	denotes	15
17244351-15987489-4361118	2952-2954	15987489	denotes	15
17244351-15743466-4361118	2952-2954	15743466	denotes	15
17244351-15158620-4361119	3201-3203	15158620	denotes	18
17244351-15987489-4361120	3325-3327	15987489	denotes	21
17244351-15743466-4361121	3328-3330	15743466	denotes	22
17244351-12482389-4361122	3481-3483	12482389	denotes	15
17244351-11908948-4361123	3484-3486	11908948	denotes	16
17244351-15529344-4361124	5057-5059	15529344	denotes	10
17244351-15529344-4361125	5532-5534	15529344	denotes	10
17244351-15529344-4361126	6544-6546	15529344	denotes	10
17244351-11707780-4361127	6785-6787	11707780	denotes	23
17244351-11908948-4361128	7609-7611	11908948	denotes	16
17244351-11134512-4361129	7949-7951	11134512	denotes	24
17244351-15529344-4361130	9404-9406	15529344	denotes	10
17244351-15529344-4361131	9931-9933	15529344	denotes	10
17244351-10754334-4361132	9934-9936	10754334	denotes	25
17244351-2563713-4361133	10589-10591	2563713	denotes	26
17244351-12594249-4361134	11187-11189	12594249	denotes	27
17244351-10453039-4361135	11297-11299	10453039	denotes	28
17244351-11046062-4361136	11453-11455	11046062	denotes	29
17244351-9724775-4361137	11924-11925	9724775	denotes	2
17244351-12687532-4361138	11926-11927	12687532	denotes	4
17244351-2563713-4361139	16431-16433	2563713	denotes	26
17244351-2563713-4361140	18052-18054	2563713	denotes	26
17244351-15529344-4361141	19088-19090	15529344	denotes	10
17244351-17082620-4361142	19392-19394	17082620	denotes	31
17244351-12482389-4361143	19858-19860	12482389	denotes	15
17244351-11908948-4361144	19861-19863	11908948	denotes	16
17244351-15987489-4361145	19864-19866	15987489	denotes	21
17244351-15743466-4361146	19867-19869	15743466	denotes	22
17244351-12951578-4361147	22112-22114	12951578	denotes	32
17244351-13130488-4361148	22179-22181	13130488	denotes	33
17244351-12951578-4361149	22247-22249	12951578	denotes	32
17244351-16418296-4361150	22360-22362	16418296	denotes	34
17244351-14607901-4361151	22587-22589	14607901	denotes	35

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T2245	675-682	PR:000002021	denotes	HLA-DR4
T2246	684-689	PR:000012222	denotes	PADI4
T2247	691-697	PR:000013457	denotes	PTPN22
T2248	702-707	PR:000007442	denotes	FCRL3
T2249	726-733	PR:000002021	denotes	HLA-DR4
T2250	802-807	SO:0000704	denotes	genes
T2251	856-861	NCBITaxon:10088	denotes	mouse
T2252	881-888	SO:0000704	denotes	genetic
T2253	979-985	SO:0001026	denotes	genome
T2254	1009-1032	SO:0000771	denotes	quantitative trait loci
T2255	1034-1037	SO:0000771	denotes	QTL
T2256	1099-1105	NCBITaxon:33208	denotes	animal
T2257	1128-1131	SO:0000771	denotes	QTL
T2258	1198-1201	SO:0000771	denotes	QTL
T2259	1351-1356	SO:0000704	denotes	genes
T2236	56-66	GO:0065007	denotes	controlled
T2237	75-80	SO:0000704	denotes	genes
T2238	203-209	UBERON:0002405	denotes	immune
T2239	271-278	SO:0000704	denotes	genetic
T2240	309-316	SO:0001026	denotes	genomic
T2241	386-393	SO:0001026	denotes	genomic
T2242	418-424	SO:0001026	denotes	genome
T2243	569-576	SO:0000704	denotes	genetic
T2244	634-639	SO:0000704	denotes	genes
T2260	1487-1493	NCBITaxon:33208	denotes	animal
T2261	1539-1546	SO:0000704	denotes	genetic
T2262	1633-1640	SO:0000704	denotes	genetic
T2263	1653-1659	NCBITaxon:33208	denotes	animal
T2264	1715-1720	SO:0000704	denotes	genes
T2265	1813-1816	SO:0000771	denotes	QTL
T2266	1845-1850	NCBITaxon:10088	denotes	mouse
T2267	1851-1857	SO:0001026	denotes	genome
T2268	1874-1877	SO:0000771	denotes	QTL
T2269	1974-1979	SO:0000704	denotes	genes
T2270	1994-1999	NCBITaxon:10088	denotes	mouse
T2271	2000-2006	SO:0001026	denotes	genome
T2272	2075-2081	NCBITaxon:33208	denotes	animal
T2273	2126-2140	SO:0000010	denotes	protein-coding
T2274	2267-2270	SO:0000771	denotes	QTL
T2275	2372-2382	GO:0065007	denotes	regulating
T2276	2383-2387	SO:0000704	denotes	gene
T2277	2383-2398	GO:0010467	denotes	gene expression
T2278	2516-2520	SO:0000704	denotes	gene
T2279	2516-2531	GO:0010467	denotes	gene expression
T2280	2620-2625	SO:0000704	denotes	genes
T2281	2682-2691	GO:0065007	denotes	regulated
T2282	2714-2719	SO:0000704	denotes	genes
T2283	2773-2783	GO:0010467	denotes	expression
T2284	2822-2829	UBERON:0000479	denotes	tissues
T2285	2937-2943	NCBITaxon:33208	denotes	animal
T2286	2968-2973	SO:0000704	denotes	genes
T2287	3010-3020	GO:0010467	denotes	expression
T2288	3041-3048	UBERON:0000479	denotes	tissues
T2289	3089-3094	SO:0000704	denotes	Genes
T2290	3107-3135	GO:0002437	denotes	immunoinflammatory responses
T2291	3156-3165	GO:0010467	denotes	expressed
T2292	3173-3178	UBERON:0000178	denotes	blood
T2293	3173-3184	CL:0000081	denotes	blood cells
T2294	3230-3239	CHEBI:36357	denotes	molecules
T2295	3264-3269	UBERON:0004905	denotes	joint
T2296	3310-3316	NCBITaxon:33208	denotes	animal
T2297	3339-3344	SO:0000704	denotes	genes
T2298	3416-3425	GO:0010467	denotes	expressed
T2299	3460-3466	NCBITaxon:33208	denotes	animal
T2300	3507-3512	SO:0000704	denotes	genes
T2301	3588-3595	SO:0000704	denotes	genetic
T2302	3610-3620	GO:0065007	denotes	regulating
T2303	3621-3625	SO:0000704	denotes	gene
T2304	3621-3636	GO:0010467	denotes	gene expression
T2305	3658-3669	GO:0010467	denotes	expressions
T2306	3739-3749	GO:0065007	denotes	regulatory
T2307	3739-3758	SO:0005836	denotes	regulatory elements
T2308	3789-3792	SO:0000771	denotes	QTL
T2309	3835-3840	SO:0000704	denotes	genes
T2310	3874-3885	SO:0000704	denotes	genetically
T2311	3932-3938	SO:0001026	denotes	genome
T2312	3972-3978	SO:0001026	denotes	genome
T2313	4079-4085	SO:0001026	denotes	genome
T2314	4147-4150	SO:0000771	denotes	QTL
T2315	4196-4200	SO:0000704	denotes	gene
T2316	4196-4211	GO:0010467	denotes	gene expression
T2317	4314-4319	SO:0000704	denotes	genes
T2318	4389-4396	SO:0001026	denotes	genomic
T2319	4460-4469	GO:0010467	denotes	expressed
T2320	4526-4535	GO:0010467	denotes	expressed
T3991	4605-4612	NCBITaxon:33208	denotes	Animals
T3992	4676-4680	NCBITaxon:10088	denotes	mice
T3993	4825-4831	NCBITaxon:33208	denotes	animal
T3994	4875-4881	NCBITaxon:33208	denotes	animal
T3995	4925-4931	NCBITaxon:33208	denotes	Animal
T3996	4992-4999	NCBITaxon:33208	denotes	animals
T3997	5168-5172	UBERON:0002415	denotes	tail
T3998	5188-5194	NCBITaxon:27592	denotes	bovine
T3999	5195-5206	PR:000003266	denotes	Collagen II
T4000	5357-5364	NCBITaxon:33208	denotes	animals
T4001	5465-5470	UBERON:0002101	denotes	limbs
T4002	5502-5506	UBERON:0002101	denotes	limb
T4003	5569-5573	NCBITaxon:10088	denotes	mice
T4004	5605-5609	SO:0000704	denotes	gene
T4005	5605-5620	GO:0010467	denotes	gene expression
T4006	5862-5866	NCBITaxon:10088	denotes	mice
T4007	5915-5919	NCBITaxon:10088	denotes	mice
T4008	5986-5990	NCBITaxon:10088	denotes	mice
T4009	6079-6083	NCBITaxon:10088	denotes	mice
T4010	6100-6104	NCBITaxon:10088	denotes	mice
T4011	6221-6225	NCBITaxon:10088	denotes	mice
T4012	6314-6318	NCBITaxon:10088	denotes	mice
T4013	6335-6339	NCBITaxon:10088	denotes	mice
T4617	6499-6505	SO:0001026	denotes	genome
T4618	6579-6583	NCBITaxon:10088	denotes	mice
T4619	6642-6648	SO:0001026	denotes	genome
T4620	6897-6900	SO:0000771	denotes	QTL
T4972	7007-7020	GO:0097617	denotes	hybridisation
T4973	7021-7032	UBERON:0000029	denotes	Lymph nodes
T4974	7034-7037	UBERON:0000029	denotes	LNs
T4975	7144-7150	UBERON:0000479	denotes	tissue
T4976	7265-7269	SO:0000704	denotes	gene
T4977	7265-7280	GO:0010467	denotes	gene expression
T4978	7381-7386	SO:0000704	denotes	genes
T4979	7489-7493	NCBITaxon:10088	denotes	mice
T4980	7499-7509	GO:0097617	denotes	hybridised
T4981	7534-7547	GO:0097617	denotes	Hybridisation
T4982	7563-7567	SO:0000704	denotes	gene
T4983	7680-7684	SO:0000704	denotes	Gene
T5583	9059-9064	SO:0000704	denotes	genes
T5566	7737-7747	GO:0010467	denotes	expression
T5567	7838-7842	SO:0000704	denotes	gene
T5568	7838-7853	GO:0010467	denotes	gene expression
T5569	7891-7901	GO:0010467	denotes	expression
T5570	7969-7978	GO:0010467	denotes	expressed
T5571	7979-7984	SO:0000704	denotes	genes
T5572	8416-8421	SO:0000704	denotes	genes
T5573	8436-8440	SO:0000704	denotes	gene
T5574	8497-8501	SO:0000704	denotes	gene
T5575	8497-8512	GO:0010467	denotes	gene expression
T5576	8570-8575	SO:0000704	denotes	genes
T5577	8617-8622	SO:0000704	denotes	genes
T5578	8716-8726	GO:0010467	denotes	expression
T5579	8745-8750	SO:0000704	denotes	genes
T5580	8843-8852	GO:0010467	denotes	expressed
T5581	8853-8858	SO:0000704	denotes	genes
T5582	8860-8864	SO:0000704	denotes	Gene
T6984	9089-9092	SO:0000771	denotes	QTL
T6985	9168-9174	SO:0001026	denotes	genome
T6986	9194-9197	SO:0000771	denotes	QTL
T6987	9198-9209	GO:0065007	denotes	controlling
T6988	9310-9313	SO:0000771	denotes	QTL
T6989	9526-9529	SO:0000771	denotes	QTL
T6990	9671-9674	SO:0000771	denotes	QTL
T6991	9794-9798	SO:0000704	denotes	gene
T6992	9808-9831	PR:000004904	denotes	complement component C5
T6993	9833-9835	PR:000004904	denotes	Hc
T6994	9917-9919	PR:000004904	denotes	C5
T6995	9957-9960	SO:0000771	denotes	QTL
T6996	10019-10021	PR:000004904	denotes	C5
T6997	10125-10127	PR:000004904	denotes	C5
T6998	10160-10162	PR:000004904	denotes	C5
T6999	10184-10191	SO:0001026	denotes	genomic
T7000	10341-10344	SO:0000771	denotes	QTL
T7001	10510-10516	SO:0001023	denotes	allele
T7002	10560-10566	SO:0001023	denotes	allele
T7003	10757-10760	SO:0000771	denotes	QTL
T7004	10805-10808	SO:0000771	denotes	QTL
T7005	10849-10856	SO:0001026	denotes	genomic
T7006	10898-10906	_FRAGMENT	denotes	syntenic
T7007	10915-10922	SO:0005858	denotes	regions
T7008	10907-10914	SO:0001026	denotes	genomic
T7009	10930-10935	NCBITaxon:9606	denotes	human
T7010	10936-10942	SO:0001026	denotes	genome
T7011	11004-11007	SO:0000771	denotes	QTL
T7012	11034-11037	SO:0000771	denotes	QTL
T7013	11045-11050	NCBITaxon:10088	denotes	mouse
T7014	11051-11057	SO:0001026	denotes	genome
T7015	11131-11138	GO:0065007	denotes	control
T7016	11337-11345	GO:0065007	denotes	controls
T7017	11364-11376	CHEBI:37396	denotes	proteoglycan
T7018	11462-11470	_FRAGMENT	denotes	syntenic
T7019	11479-11486	SO:0005858	denotes	regions
T7020	11471-11478	SO:0001026	denotes	genomic
T7021	11508-11511	SO:0000771	denotes	QTL
T7022	11519-11524	NCBITaxon:9606	denotes	human
T7023	11525-11531	SO:0001026	denotes	genome
T7024	11581-11588	SO:0001026	denotes	genomic
T8259	11962-11971	GO:0010467	denotes	expressed
T8260	11972-11977	SO:0000704	denotes	genes
T8261	11994-11998	SO:0000704	denotes	gene
T8262	11994-12009	GO:0010467	denotes	gene expression
T8263	12031-12035	NCBITaxon:10088	denotes	mice
T8264	12220-12224	SO:0000704	denotes	gene
T8265	12511-12520	GO:0010467	denotes	expressed
T8266	12521-12526	SO:0000704	denotes	genes
T8267	12556-12560	SO:0000704	denotes	gene
T8268	12556-12571	GO:0010467	denotes	gene expression
T8269	12678-12682	NCBITaxon:10088	denotes	mice
T8270	12709-12714	SO:0000704	denotes	genes
T8271	12735-12744	GO:0010467	denotes	expressed
T8272	12860-12865	SO:0000704	denotes	genes
T8273	12886-12895	GO:0010467	denotes	expressed
T8274	12909-12913	NCBITaxon:10088	denotes	mice
T8275	12955-12964	GO:0010467	denotes	expressed
T8276	12965-12970	SO:0000704	denotes	genes
T8277	13097-13106	GO:0010467	denotes	expressed
T8278	13107-13112	SO:0000704	denotes	genes
T8279	13160-13165	SO:0000704	denotes	genes
T8280	13185-13190	SO:0000704	denotes	genes
T8281	13239-13244	SO:0000704	denotes	genes
T8282	13278-13288	GO:0010467	denotes	expression
T8283	13345-13350	SO:0000704	denotes	genes
T8284	13370-13375	SO:0000704	denotes	genes
T8285	13412-13421	GO:0010467	denotes	expressed
T9422	13522-13531	GO:0010467	denotes	expressed
T9423	13532-13537	SO:0000704	denotes	genes
T9424	13586-13595	GO:0010467	denotes	expressed
T9425	13596-13601	SO:0000704	denotes	genes
T9426	13626-13631	SO:0000704	denotes	genes
T9427	13657-13666	GO:0010467	denotes	expressed
T9428	13670-13673	UBERON:0000029	denotes	LNs
T9429	13825-13830	SO:0000704	denotes	genes
T9430	13851-13860	GO:0010467	denotes	expressed
T9431	13960-13965	SO:0000704	denotes	genes
T9432	13986-13995	GO:0010467	denotes	expressed
T9433	14053-14062	GO:0010467	denotes	expressed
T9434	14063-14068	SO:0000704	denotes	genes
T9435	14109-14114	SO:0000704	denotes	genes
T9436	14125-14129	SO:0000704	denotes	gene
T9437	14149-14158	GO:0010467	denotes	expressed
T9438	14200-14204	SO:0000704	denotes	gene
T9439	14239-14248	GO:0010467	denotes	expressed
T9440	14249-14254	SO:0000704	denotes	genes
T9441	14387-14396	GO:0010467	denotes	expressed
T9442	14397-14402	SO:0000704	denotes	genes
T9443	14423-14432	GO:0065007	denotes	regulated
T9444	14453-14457	NCBITaxon:10088	denotes	mice
T9445	14507-14511	SO:0000704	denotes	gene
T9446	14507-14522	GO:0010467	denotes	gene expression
T9447	14600-14605	SO:0000704	denotes	genes
T9448	14611-14615	SO:0000704	denotes	gene
T9449	14693-14697	SO:0000704	denotes	gene
T9450	14693-14708	GO:0010467	denotes	gene expression
T9451	14751-14756	SO:0000704	denotes	genes
T9452	14771-14776	SO:0000704	denotes	genes
T9453	14827-14837	GO:0010467	denotes	expression
T9454	14847-14852	SO:0000704	denotes	genes
T9455	14974-14980	UBERON:0002405	denotes	immune
T9456	14974-14989	GO:0006955	denotes	immune response
T9457	15014-15019	SO:0000704	denotes	genes
T9458	15026-15036	GO:0010467	denotes	expression
T9459	15117-15122	SO:0000704	denotes	genes
T9460	15149-15155	UBERON:0002405	denotes	immune
T9461	15149-15164	GO:0006955	denotes	immune response
T9462	15166-15184	GO:0031090	denotes	organelle membrane
T9463	15189-15209	GO:0005576	denotes	extracellular region
T9464	15189-15202	_FRAGMENT	denotes	extracellular
T9465	15214-15219	GO:0005615	denotes	space
T9466	15245-15250	SO:0000704	denotes	genes
T9467	15301-15306	SO:0000704	denotes	genes
T9468	15326-15348	GO:0005911	denotes	intercellular junction
T9469	15372-15377	SO:0000704	denotes	genes
T9470	15426-15431	SO:0000704	denotes	genes
T9471	15487-15492	SO:0000704	denotes	genes
T9472	15521-15531	CL:0000542	denotes	lymphocyte
T9473	15521-15545	GO:0046651	denotes	lymphocyte proliferation
T9474	15547-15553	CL:0000084	denotes	T cell
T9475	15547-15564	GO:0042110	denotes	T cell activation
T9476	15597-15617	GO:0007219	denotes	notch signal pathway
T9477	15644-15649	SO:0000704	denotes	genes
T9478	15704-15709	SO:0000704	denotes	genes
T9479	15842-15846	SO:0000704	denotes	gene
T10686	15868-15873	SO:0000704	denotes	genes
T10687	15895-15898	SO:0000771	denotes	QTL
T10688	15974-15977	SO:0000771	denotes	QTL
T10689	16034-16043	GO:0010467	denotes	expressed
T10690	16044-16049	SO:0000704	denotes	genes
T10691	16099-16108	GO:0010467	denotes	expressed
T10692	16109-16114	SO:0000704	denotes	genes
T10693	16120-16125	SO:0000704	denotes	genes
T10694	16214-16219	SO:0000704	denotes	genes
T10695	16282-16285	SO:0000771	denotes	QTL
T10696	16395-16398	SO:0000771	denotes	QTL
T10697	16503-16508	SO:0000704	denotes	genes
T10698	16570-16573	SO:0000771	denotes	QTL
T10699	16626-16631	SO:0000704	denotes	genes
T10700	16726-16730	SO:0000704	denotes	gene
T10701	16800-16805	SO:0000704	denotes	genes
T10702	16836-16841	SO:0000704	denotes	genes
T10703	16843-16849	PR:000008871	denotes	hspa1a
T10704	16854-16859	PR:000012101	denotes	Oas1a
T10705	16905-16910	PR:000012101	denotes	Oas1a
T10706	16970-16975	SO:0000704	denotes	genes
T10707	16990-16995	SO:0000704	denotes	genes
T10708	17048-17053	SO:0000704	denotes	genes
T10709	17062-17068	PR:000008871	denotes	hspa1a
T10710	17077-17087	GO:0010467	denotes	expression
T10711	17146-17151	SO:0000704	denotes	genes
T10712	17172-17181	GO:0010467	denotes	expressed
T10713	17214-17220	PR:000008409	denotes	H2-Q10
T10714	17222-17228	PR:000003107	denotes	Mapk14
T10715	17230-17235	PR:000006153	denotes	Pscd1
T10716	17237-17242	PR:000009439	denotes	Kpnb1
T10717	17247-17251	PR:000017387	denotes	Wdr1
T10718	17270-17275	SO:0000704	denotes	genes
T10719	17277-17283	PR:000008409	denotes	H2-Q10
T10720	17310-17320	GO:0010467	denotes	expression
T10721	17396-17401	SO:0000704	denotes	genes
T10722	17415-17425	GO:0010467	denotes	expression
T10723	17504-17514	GO:0010467	denotes	expression
T10724	17679-17684	SO:0000704	denotes	genes
T10725	17725-17730	SO:0000704	denotes	genes
T10726	17742-17748	PR:000003107	denotes	Mapk14
T10727	17750-17758	PR:000010162	denotes	Mapk8ip3
T10728	17760-17766	PR:000002091	denotes	Stat5a
T10729	17771-17776	PR:000008081	denotes	Gna12
T13213	19043-19046	SO:0000771	denotes	QTL
T13214	19125-19132	SO:0001026	denotes	genomic
T13215	19152-19155	SO:0000771	denotes	QTL
T13216	19156-19167	GO:0065007	denotes	controlling
T13217	19174-19182	GO:0042571	denotes	antibody
T13218	19193-19204	PR:000003266	denotes	collagen II
T13219	19237-19240	SO:0000771	denotes	QTL
T13220	19255-19262	SO:0001026	denotes	genomic
T13221	19288-19292	SO:0000704	denotes	gene
T13222	19312-19321	GO:0065007	denotes	regulates
T13223	19338-19349	GO:0065007	denotes	controlling
T13224	19360-19368	GO:0042571	denotes	antibody
T13225	19379-19390	PR:000003266	denotes	collagen II
T13226	19447-19455	GO:0065007	denotes	controls
T13227	19456-19466	CL:0000542	denotes	lymphocyte
T13228	19456-19480	GO:0046651	denotes	lymphocyte proliferation
T13229	19554-19562	GO:0065007	denotes	controls
T13230	19563-19573	CL:0000542	denotes	lymphocyte
T13191	17862-17865	SO:0000771	denotes	QTL
T13192	17897-17900	SO:0000771	denotes	QTL
T13193	18137-18140	SO:0000771	denotes	QTL
T13194	18171-18176	SO:0000704	denotes	genes
T13195	18278-18280	PR:000004904	denotes	C5
T13196	18303-18305	PR:000004904	denotes	C5
T13197	18352-18355	SO:0000771	denotes	QTL
T13198	18420-18423	SO:0000771	denotes	QTL
T13199	18455-18458	SO:0000771	denotes	QTL
T13200	18514-18517	SO:0000771	denotes	QTL
T13201	18584-18592	SO:0000860	denotes	syntenic
T13202	18632-18639	SO:0001026	denotes	genomic
T13203	18655-18660	NCBITaxon:9606	denotes	human
T13204	18661-18667	SO:0001026	denotes	genome
T13205	18691-18694	SO:0000771	denotes	QTL
T13206	18748-18751	SO:0000771	denotes	QTL
T13207	18762-18769	SO:0001023	denotes	alleles
T13208	18798-18805	SO:0001023	denotes	alleles
T13209	18822-18829	SO:0001023	denotes	alleles
T13210	18858-18865	SO:0001023	denotes	alleles
T13211	18885-18888	SO:0000771	denotes	QTL
T13212	18926-18931	SO:0000704	denotes	genes
T13231	19626-19630	SO:0000704	denotes	gene
T13232	19655-19658	SO:0000771	denotes	QTL
T13233	19693-19704	GO:0065007	denotes	controlling
T13234	19783-19787	SO:0000704	denotes	gene
T13235	19783-19798	GO:0010467	denotes	gene expression
T13236	19829-19835	UBERON:0004905	denotes	joints
T13237	19850-19856	UBERON:0000479	denotes	tissue
T13238	19913-19917	SO:0000704	denotes	gene
T13239	19913-19928	GO:0010467	denotes	gene expression
T13240	19932-19935	UBERON:0000029	denotes	LNs
T13241	19981-19985	SO:0000704	denotes	gene
T13242	19981-19996	GO:0010467	denotes	gene expression
T13243	20009-20012	UBERON:0000029	denotes	LNs
T13244	20021-20032	SO:0000704	denotes	genetically
T13245	20132-20141	GO:0065007	denotes	regulated
T13246	20142-20147	SO:0000704	denotes	genes
T13247	20225-20230	SO:0000704	denotes	genes
T13248	20251-20260	GO:0010467	denotes	expressed
T13249	20329-20332	UBERON:0000029	denotes	LNs
T13250	20554-20559	SO:0000704	denotes	genes
T13251	20590-20595	SO:0000704	denotes	genes
T13252	20609-20619	GO:0010467	denotes	expression
T13253	20703-20713	GO:0010467	denotes	expression
T13254	20782-20787	SO:0000704	denotes	genes
T13255	20804-20814	CL:0000542	denotes	lymphocyte
T13256	20804-20828	GO:0046651	denotes	lymphocyte proliferation
T13257	20804-20814	_FRAGMENT	denotes	lymphocyte
T13258	20833-20843	GO:0046649	denotes	activation
T13259	20861-20872	CL:0000542	denotes	lymphocytes
T13260	21001-21011	GO:0010467	denotes	expression
T13261	21058-21062	NCBITaxon:10088	denotes	mice
T13262	21104-21109	SO:0000704	denotes	genes
T13263	21125-21131	UBERON:0002405	denotes	immune
T13264	21125-21140	GO:0006955	denotes	immune response
T13265	21263-21271	GO:0042571	denotes	antibody
T13266	21263-21280	GO:0016064	denotes	antibody response
T13267	21284-21295	PR:000003266	denotes	collagen II
T13268	21460-21465	SO:0000704	denotes	genes
T13269	21505-21510	SO:0000704	denotes	genes
T13270	21545-21548	SO:0000771	denotes	QTL
T13271	21568-21572	SO:0000704	denotes	gene
T13272	21568-21583	GO:0010467	denotes	gene expression
T13273	21614-21621	SO:0001026	denotes	genomic
T13274	21646-21651	SO:0000704	denotes	genes
T13275	21668-21671	SO:0000771	denotes	QTL
T13276	21737-21742	SO:0000704	denotes	genes
T13277	21760-21763	SO:0000771	denotes	QTL
T13278	21798-21808	GO:0065007	denotes	regulating
T13279	21809-21813	SO:0000704	denotes	gene
T13280	21809-21824	GO:0010467	denotes	gene expression
T13281	21850-21855	SO:0000704	denotes	genes
T13282	21899-21905	PR:000003107	denotes	Mapk14
T13283	21919-21923	SO:0000704	denotes	gene
T13284	21952-21988	_FRAGMENT	denotes	p38 mitogen-activated protein kinase
T13285	21996-22001	PR:000003107	denotes	alpha
T13286	21952-21955	_FRAGMENT	denotes	p38
T13287	21990-21994	_FRAGMENT	denotes	MAPK
T13288	21956-21963	CHEBI:52290	denotes	mitogen
T13289	22003-22012	GO:0065007	denotes	regulates
T13290	22097-22110	PR:000001091	denotes	interleukin-1
T13291	22127-22140	_FRAGMENT	denotes	inhibitors of
T13292	22145-22149	CHEBI:79091	denotes	MAPK
T13293	22141-22149	PR:000003106	denotes	p38 MAPK
T13294	22173-22177	NCBITaxon:10114	denotes	rats
T13295	22188-22196	PR:000003106	denotes	p38 MAPK
T13296	22252-22258	PR:000002091	denotes	Stat5a
T13297	22272-22276	SO:0000704	denotes	gene
T13298	22305-22313	CHEBI:36357	denotes	molecule
T13299	22365-22371	PR:000002091	denotes	Stat5a
T13300	22382-22386	NCBITaxon:10088	denotes	mice
T13301	22456-22462	UBERON:0002405	denotes	immune
T13302	22473-22479	PR:000002091	denotes	Stat5a
T13303	22547-22550	PR:000001004	denotes	CD4
T13304	22551-22555	PR:000001380	denotes	CD25
T13305	22557-22567	GO:0065007	denotes	regulatory
T13306	22557-22574	CL:0000815	denotes	regulatory T cell
T13307	22657-22660	SO:0000771	denotes	QTL
T14887	23574-23579	SO:0000704	denotes	genes
T14888	23597-23600	SO:0000771	denotes	QTL
T14889	23649-23654	SO:0000704	denotes	genes
T14890	23674-23677	SO:0000771	denotes	QTL
T14891	23678-23688	GO:0065007	denotes	regulating
T14892	23803-23810	NCBITaxon:33208	denotes	animals
T14893	23838-23841	SO:0000771	denotes	QTL
T14894	23926-23929	SO:0000771	denotes	QTL
T14895	23978-23983	SO:0000704	denotes	genes
T14896	23995-24000	NCBITaxon:10088	denotes	mouse
T14897	24005-24010	NCBITaxon:9606	denotes	human
T14898	24030-24035	SO:0000704	denotes	genes
T14899	24162-24166	NCBITaxon:10088	denotes	mice
T14900	24198-24203	SO:0000704	denotes	genes
T14901	24251-24256	NCBITaxon:9606	denotes	human
T14902	24257-24263	SO:0001026	denotes	genome
T14903	24316-24321	SO:0000704	denotes	genes
T13308	22696-22701	SO:0000704	denotes	genes
T13309	22796-22803	NCBITaxon:33208	denotes	animals
T13310	22864-22870	SO:0001026	denotes	genome
T13311	22909-22912	SO:0000771	denotes	QTL
T13312	23111-23114	SO:0000771	denotes	QTL
T13313	23164-23171	NCBITaxon:33208	denotes	animals
T13314	23219-23223	SO:0000704	denotes	gene
T13315	23219-23234	GO:0010467	denotes	gene expression
T13316	23294-23303	GO:0010467	denotes	expressed
T13317	23304-23309	SO:0000704	denotes	genes
T13318	23341-23351	GO:0010467	denotes	expression
T13319	23357-23361	SO:0000704	denotes	gene
T13320	23389-23395	SO:0001023	denotes	allele
R1820	T7007	T7006	_lexicallyChainedTo	regions,syntenic
R1821	T7019	T7018	_lexicallyChainedTo	regions,syntenic
R2722	T9465	T9464	_lexicallyChainedTo	space,extracellular
R3512	T13258	T13257	_lexicallyChainedTo	activation,lymphocyte
R3513	T13285	T13284	_lexicallyChainedTo	alpha,p38 mitogen-activated protein kinase
R3514	T13285	T13287	_lexicallyChainedTo	alpha,MAPK
R3515	T13287	T13286	_lexicallyChainedTo	MAPK,p38
R3516	T13292	T13291	_lexicallyChainedTo	MAPK,inhibitors of

PMC:1860061 / 1269-27666 JSONTXT

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PMC:1860061 / 1269-27666 JSON TXT