PMC:1860061 / 10336-19046 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T7078	9-14	JJ	denotes	Small
T7079	15-21	NN	denotes	effect
T7080	14-15	HYPH	denotes	-
T7081	22-25	NNS	denotes	QTL
T7082	26-28	IN	denotes	of
T7083	29-32	NN	denotes	CIA
T7084	33-35	IN	denotes	in
T7085	36-37	-LRB-	denotes	(
T7086	37-40	NN	denotes	DBA
T7087	55-62	NN	denotes	progeny
T7088	40-41	HYPH	denotes	/
T7089	41-42	CD	denotes	1
T7090	43-44	SYM	denotes	×
T7091	45-48	NN	denotes	FVB
T7092	49-50	NN	denotes	N
T7093	48-49	HYPH	denotes	/
T7094	50-51	-RRB-	denotes	)
T7095	52-54	NN	denotes	F2
T7096	62-192	sentence	denotes	In a previous study, we carried out a genome screen to identify QTL controlling CIA susceptibility in (DBA/1 × FVB/N) F2 progeny.
T7097	63-65	IN	denotes	In
T7098	87-94	VBD	denotes	carried
T7099	66-67	DT	denotes	a
T7100	77-82	NN	denotes	study
T7101	68-76	JJ	denotes	previous
T7102	82-84	,	denotes	,
T7103	84-86	PRP	denotes	we
T7104	95-98	RP	denotes	out
T7105	99-100	DT	denotes	a
T7106	108-114	NN	denotes	screen
T7107	101-107	NN	denotes	genome
T7108	115-117	TO	denotes	to
T7109	118-126	VB	denotes	identify
T7110	127-130	NN	denotes	QTL
T7111	131-142	VBG	denotes	controlling
T7112	143-146	NN	denotes	CIA
T7113	147-161	NN	denotes	susceptibility
T7114	162-164	IN	denotes	in
T7115	165-166	-LRB-	denotes	(
T7116	166-169	NN	denotes	DBA
T7117	184-191	NN	denotes	progeny
T7118	169-170	HYPH	denotes	/
T7119	170-171	CD	denotes	1
T7120	172-173	SYM	denotes	×
T7121	178-179	NN	denotes	N
T7122	174-177	NN	denotes	FVB
T7123	177-178	HYPH	denotes	/
T7124	179-180	-RRB-	denotes	)
T7125	181-183	NN	denotes	F2
T7126	191-192	.	denotes	.
T7127	192-341	sentence	denotes	For the phenotype of arthritis severity, only one QTL, Cia2, was identified, with a highly significant logarithm of the odds (LOD) score of 12 [10].
T7128	193-196	IN	denotes	For
T7129	258-268	VBN	denotes	identified
T7130	197-200	DT	denotes	the
T7131	201-210	NN	denotes	phenotype
T7132	211-213	IN	denotes	of
T7133	214-223	NN	denotes	arthritis
T7134	224-232	NN	denotes	severity
T7135	232-234	,	denotes	,
T7136	234-238	RB	denotes	only
T7137	243-246	NN	denotes	QTL
T7138	239-242	CD	denotes	one
T7139	246-248	,	denotes	,
T7140	248-252	NN	denotes	Cia2
T7141	252-254	,	denotes	,
T7142	254-257	VBD	denotes	was
T7143	268-270	,	denotes	,
T7144	270-274	IN	denotes	with
T7145	275-276	DT	denotes	a
T7146	324-329	NN	denotes	score
T7147	277-283	RB	denotes	highly
T7148	284-295	JJ	denotes	significant
T7149	296-305	NN	denotes	logarithm
T7150	306-308	IN	denotes	of
T7151	309-312	DT	denotes	the
T7152	313-317	NNS	denotes	odds
T7153	318-319	-LRB-	denotes	(
T7154	319-322	NN	denotes	LOD
T7155	322-323	-RRB-	denotes	)
T7156	330-332	IN	denotes	of
T7157	333-335	CD	denotes	12
T7158	336-337	-LRB-	denotes	[
T7159	337-339	CD	denotes	10
T7160	339-340	-RRB-	denotes	]
T7161	340-341	.	denotes	.
T7162	341-562	sentence	denotes	However, Cia2 contributed to only 16% of the phenotype variations, indicating that there should be some small-effect QTL whose contributions to CIA were not big enough to reach the significant threshold value of linkage.
T7163	342-349	RB	denotes	However
T7164	356-367	VBD	denotes	contributed
T7165	349-351	,	denotes	,
T7166	351-355	NN	denotes	Cia2
T7167	368-370	IN	denotes	to
T7168	371-375	RB	denotes	only
T7169	378-379	NN	denotes	%
T7170	376-378	CD	denotes	16
T7171	380-382	IN	denotes	of
T7172	383-386	DT	denotes	the
T7173	397-407	NNS	denotes	variations
T7174	387-396	NN	denotes	phenotype
T7175	407-409	,	denotes	,
T7176	409-419	VBG	denotes	indicating
T7177	420-424	IN	denotes	that
T7178	438-440	VB	denotes	be
T7179	425-430	EX	denotes	there
T7180	431-437	MD	denotes	should
T7181	441-445	DT	denotes	some
T7182	459-462	NNS	denotes	QTL
T7183	446-451	JJ	denotes	small
T7184	452-458	NN	denotes	effect
T7185	451-452	HYPH	denotes	-
T7186	463-468	WP$	denotes	whose
T7187	469-482	NNS	denotes	contributions
T7188	490-494	VBD	denotes	were
T7189	483-485	IN	denotes	to
T7190	486-489	NN	denotes	CIA
T7191	495-498	RB	denotes	not
T7192	499-502	JJ	denotes	big
T7193	503-509	RB	denotes	enough
T7194	510-512	TO	denotes	to
T7195	513-518	VB	denotes	reach
T7196	519-522	DT	denotes	the
T7197	545-550	NN	denotes	value
T7198	523-534	JJ	denotes	significant
T7199	535-544	NN	denotes	threshold
T7200	551-553	IN	denotes	of
T7201	554-561	NN	denotes	linkage
T7202	561-562	.	denotes	.
T7203	562-684	sentence	denotes	To identify these potential small-effect QTL, we reanalyzed the data using a lower threshold value of linkage (P = 0.05).
T7204	563-565	TO	denotes	To
T7205	566-574	VB	denotes	identify
T7206	612-622	VBD	denotes	reanalyzed
T7207	575-580	DT	denotes	these
T7208	604-607	NNS	denotes	QTL
T7209	581-590	JJ	denotes	potential
T7210	591-596	JJ	denotes	small
T7211	597-603	NN	denotes	effect
T7212	596-597	HYPH	denotes	-
T7213	607-609	,	denotes	,
T7214	609-611	PRP	denotes	we
T7215	623-626	DT	denotes	the
T7216	627-631	NNS	denotes	data
T7217	632-637	VBG	denotes	using
T7218	638-639	DT	denotes	a
T7219	656-661	NN	denotes	value
T7220	640-645	JJR	denotes	lower
T7221	646-655	NN	denotes	threshold
T7222	662-664	IN	denotes	of
T7223	665-672	NN	denotes	linkage
T7224	673-674	-LRB-	denotes	(
T7225	678-682	CD	denotes	0.05
T7226	674-675	NN	denotes	P
T7227	676-677	SYM	denotes	=
T7228	682-683	-RRB-	denotes	)
T7229	683-684	.	denotes	.
T7230	684-918	sentence	denotes	We reasoned that since the main candidate gene of Cia2, complement component C5 (Hc), was proven to be essential for CIA development and because the FVB/N strain is C5 deficient [10,25], some small-effect QTL might be masked by Cia2.
T7231	685-687	PRP	denotes	We
T7232	688-696	VBD	denotes	reasoned
T7233	697-701	IN	denotes	that
T7234	903-909	VBN	denotes	masked
T7235	702-707	IN	denotes	since
T7236	775-781	VBN	denotes	proven
T7237	708-711	DT	denotes	the
T7238	727-731	NN	denotes	gene
T7239	712-716	JJ	denotes	main
T7240	717-726	NN	denotes	candidate
T7241	732-734	IN	denotes	of
T7242	735-739	NN	denotes	Cia2
T7243	739-741	,	denotes	,
T7244	741-751	NN	denotes	complement
T7245	762-764	NN	denotes	C5
T7246	752-761	NN	denotes	component
T7247	765-766	-LRB-	denotes	(
T7248	766-768	NN	denotes	Hc
T7249	768-769	-RRB-	denotes	)
T7250	769-771	,	denotes	,
T7251	771-774	VBD	denotes	was
T7252	782-784	TO	denotes	to
T7253	785-787	VB	denotes	be
T7254	788-797	JJ	denotes	essential
T7255	798-801	IN	denotes	for
T7256	802-805	NN	denotes	CIA
T7257	806-817	NN	denotes	development
T7258	818-821	CC	denotes	and
T7259	822-829	IN	denotes	because
T7260	847-849	VBZ	denotes	is
T7261	830-833	DT	denotes	the
T7262	840-846	NN	denotes	strain
T7263	834-837	NN	denotes	FVB
T7264	838-839	NN	denotes	N
T7265	837-838	HYPH	denotes	/
T7266	850-852	NN	denotes	C5
T7267	853-862	JJ	denotes	deficient
T7268	863-864	-LRB-	denotes	[
T7269	867-869	CD	denotes	25
T7270	864-866	CD	denotes	10
T7271	866-867	,	denotes	,
T7272	869-870	-RRB-	denotes	]
T7273	870-872	,	denotes	,
T7274	872-876	DT	denotes	some
T7275	890-893	NNS	denotes	QTL
T7276	877-882	JJ	denotes	small
T7277	883-889	NN	denotes	effect
T7278	882-883	HYPH	denotes	-
T7279	894-899	MD	denotes	might
T7280	900-902	VB	denotes	be
T7281	910-912	IN	denotes	by
T7282	913-917	NN	denotes	Cia2
T7283	917-918	.	denotes	.
T7284	918-1110	sentence	denotes	To exclude the masking effect of C5, we performed linkage analysis with 3 datasets, the first containing all 290 F2 progeny, the second 77 C5+/+ F2 progeny and the third 133 C5+/- F2 progeny.
T7285	919-921	TO	denotes	To
T7286	922-929	VB	denotes	exclude
T7287	959-968	VBD	denotes	performed
T7288	930-933	DT	denotes	the
T7289	942-948	NN	denotes	effect
T7290	934-941	NN	denotes	masking
T7291	949-951	IN	denotes	of
T7292	952-954	NN	denotes	C5
T7293	954-956	,	denotes	,
T7294	956-958	PRP	denotes	we
T7295	969-976	NN	denotes	linkage
T7296	977-985	NN	denotes	analysis
T7297	986-990	IN	denotes	with
T7298	991-992	CD	denotes	3
T7299	993-1001	NNS	denotes	datasets
T7300	1001-1003	,	denotes	,
T7301	1003-1006	DT	denotes	the
T7302	1007-1012	JJ	denotes	first
T7303	1013-1023	VBG	denotes	containing
T7304	1024-1027	DT	denotes	all
T7305	1035-1042	NN	denotes	progeny
T7306	1028-1031	CD	denotes	290
T7307	1032-1034	NN	denotes	F2
T7308	1042-1044	,	denotes	,
T7309	1044-1047	DT	denotes	the
T7310	1048-1054	JJ	denotes	second
T7311	1067-1074	NN	denotes	progeny
T7312	1055-1057	CD	denotes	77
T7313	1058-1061	NN	denotes	C5+
T7314	1061-1062	HYPH	denotes	/
T7315	1062-1063	SYM	denotes	+
T7316	1064-1066	NN	denotes	F2
T7317	1075-1078	CC	denotes	and
T7318	1079-1082	DT	denotes	the
T7319	1083-1088	JJ	denotes	third
T7320	1102-1109	NN	denotes	progeny
T7321	1089-1092	CD	denotes	133
T7322	1093-1096	NN	denotes	C5+
T7323	1096-1097	HYPH	denotes	/
T7324	1097-1098	SYM	denotes	-
T7325	1099-1101	NN	denotes	F2
T7326	1109-1110	.	denotes	.
T7327	1110-1248	sentence	denotes	Eight genomic regions were linked to the phenotype of CIA severity (loci 1 to 8, Table 2), with P values varying between 0.043 and 0.003.
T7328	1111-1116	CD	denotes	Eight
T7329	1125-1132	NNS	denotes	regions
T7330	1117-1124	JJ	denotes	genomic
T7331	1138-1144	VBN	denotes	linked
T7332	1133-1137	VBD	denotes	were
T7333	1145-1147	IN	denotes	to
T7334	1148-1151	DT	denotes	the
T7335	1152-1161	NN	denotes	phenotype
T7336	1162-1164	IN	denotes	of
T7337	1165-1168	NN	denotes	CIA
T7338	1169-1177	NN	denotes	severity
T7339	1178-1179	-LRB-	denotes	(
T7340	1192-1197	NN	denotes	Table
T7341	1179-1183	NNS	denotes	loci
T7342	1184-1185	CD	denotes	1
T7343	1186-1188	IN	denotes	to
T7344	1189-1190	CD	denotes	8
T7345	1190-1192	,	denotes	,
T7346	1198-1199	CD	denotes	2
T7347	1199-1200	-RRB-	denotes	)
T7348	1200-1202	,	denotes	,
T7349	1202-1206	IN	denotes	with
T7350	1216-1223	VBG	denotes	varying
T7351	1207-1208	NN	denotes	P
T7352	1209-1215	NNS	denotes	values
T7353	1224-1231	IN	denotes	between
T7354	1232-1237	CD	denotes	0.043
T7355	1238-1241	CC	denotes	and
T7356	1242-1247	CD	denotes	0.003
T7357	1247-1248	.	denotes	.
T7358	1248-1334	sentence	denotes	These eight small-effect QTL were located on chromosomes 5, 6, 7, 10, 11, 16, and 17.
T7359	1249-1254	DT	denotes	These
T7360	1274-1277	NNS	denotes	QTL
T7361	1255-1260	CD	denotes	eight
T7362	1261-1266	JJ	denotes	small
T7363	1267-1273	NN	denotes	effect
T7364	1266-1267	HYPH	denotes	-
T7365	1283-1290	VBN	denotes	located
T7366	1278-1282	VBD	denotes	were
T7367	1291-1293	IN	denotes	on
T7368	1294-1305	NNS	denotes	chromosomes
T7369	1306-1307	CD	denotes	5
T7370	1307-1309	,	denotes	,
T7371	1309-1310	CD	denotes	6
T7372	1310-1312	,	denotes	,
T7373	1312-1313	CD	denotes	7
T7374	1313-1315	,	denotes	,
T7375	1315-1317	CD	denotes	10
T7376	1317-1319	,	denotes	,
T7377	1319-1321	CD	denotes	11
T7378	1321-1323	,	denotes	,
T7379	1323-1325	CD	denotes	16
T7380	1325-1327	,	denotes	,
T7381	1327-1330	CC	denotes	and
T7382	1331-1333	CD	denotes	17
T7383	1333-1334	.	denotes	.
T7384	1334-1386	sentence	denotes	Five loci were identified in at least two datasets.
T7385	1335-1339	CD	denotes	Five
T7386	1340-1344	NNS	denotes	loci
T7387	1350-1360	VBN	denotes	identified
T7388	1345-1349	VBD	denotes	were
T7389	1361-1363	IN	denotes	in
T7390	1364-1366	RB	denotes	at
T7391	1373-1376	CD	denotes	two
T7392	1367-1372	RBS	denotes	least
T7393	1377-1385	NNS	denotes	datasets
T7394	1385-1386	.	denotes	.
T7395	1386-1500	sentence	denotes	Of the eight loci, five had DBA/1 as the susceptibility allele, and three had FVB/N as the susceptibility allele.
T7396	1387-1389	IN	denotes	Of
T7397	1411-1414	VBD	denotes	had
T7398	1390-1393	DT	denotes	the
T7399	1400-1404	NNS	denotes	loci
T7400	1394-1399	CD	denotes	eight
T7401	1404-1406	,	denotes	,
T7402	1406-1410	CD	denotes	five
T7403	1415-1418	NN	denotes	DBA
T7404	1418-1419	HYPH	denotes	/
T7405	1419-1420	CD	denotes	1
T7406	1421-1423	IN	denotes	as
T7407	1424-1427	DT	denotes	the
T7408	1443-1449	NN	denotes	allele
T7409	1428-1442	NN	denotes	susceptibility
T7410	1449-1451	,	denotes	,
T7411	1451-1454	CC	denotes	and
T7412	1455-1460	CD	denotes	three
T7413	1461-1464	VBD	denotes	had
T7414	1465-1468	NN	denotes	FVB
T7415	1469-1470	NN	denotes	N
T7416	1468-1469	HYPH	denotes	/
T7417	1471-1473	IN	denotes	as
T7418	1474-1477	DT	denotes	the
T7419	1493-1499	NN	denotes	allele
T7420	1478-1492	NN	denotes	susceptibility
T7421	1499-1500	.	denotes	.
T7422	1500-1742	sentence	denotes	Lander and Botstein [26] suggested a LOD score of between 2 and 3 to ensure an overall false positive rate of 5%, which means that using a lower threshold value will prevent false negative QTL at the expense of increasing false positive QTL.
T7423	1501-1507	NNP	denotes	Lander
T7424	1526-1535	VBD	denotes	suggested
T7425	1508-1511	CC	denotes	and
T7426	1512-1520	NNP	denotes	Botstein
T7427	1521-1522	-LRB-	denotes	[
T7428	1522-1524	CD	denotes	26
T7429	1524-1525	-RRB-	denotes	]
T7430	1536-1537	DT	denotes	a
T7431	1542-1547	NN	denotes	score
T7432	1538-1541	NN	denotes	LOD
T7433	1548-1550	IN	denotes	of
T7434	1551-1558	IN	denotes	between
T7435	1559-1560	CD	denotes	2
T7436	1561-1564	CC	denotes	and
T7437	1565-1566	CD	denotes	3
T7438	1567-1569	TO	denotes	to
T7439	1570-1576	VB	denotes	ensure
T7440	1577-1579	DT	denotes	an
T7441	1603-1607	NN	denotes	rate
T7442	1580-1587	JJ	denotes	overall
T7443	1588-1593	JJ	denotes	false
T7444	1594-1602	JJ	denotes	positive
T7445	1608-1610	IN	denotes	of
T7446	1611-1612	CD	denotes	5
T7447	1612-1613	NN	denotes	%
T7448	1613-1615	,	denotes	,
T7449	1615-1620	WDT	denotes	which
T7450	1621-1626	VBZ	denotes	means
T7451	1627-1631	IN	denotes	that
T7452	1667-1674	VB	denotes	prevent
T7453	1632-1637	VBG	denotes	using
T7454	1638-1639	DT	denotes	a
T7455	1656-1661	NN	denotes	value
T7456	1640-1645	JJR	denotes	lower
T7457	1646-1655	NN	denotes	threshold
T7458	1662-1666	MD	denotes	will
T7459	1675-1680	JJ	denotes	false
T7460	1681-1689	JJ	denotes	negative
T7461	1690-1693	NNS	denotes	QTL
T7462	1694-1696	IN	denotes	at
T7463	1697-1700	DT	denotes	the
T7464	1701-1708	NN	denotes	expense
T7465	1709-1711	IN	denotes	of
T7466	1712-1722	VBG	denotes	increasing
T7467	1723-1728	JJ	denotes	false
T7468	1729-1737	JJ	denotes	positive
T7469	1738-1741	NNS	denotes	QTL
T7470	1741-1742	.	denotes	.
T7471	1742-1918	sentence	denotes	Being aware of this, we examined these genomic regions to search whether they, or their syntenic genomic regions on the human genome, have been previously linked to arthritis.
T7472	1743-1748	VBG	denotes	Being
T7473	1767-1775	VBD	denotes	examined
T7474	1749-1754	JJ	denotes	aware
T7475	1755-1757	IN	denotes	of
T7476	1758-1762	DT	denotes	this
T7477	1762-1764	,	denotes	,
T7478	1764-1766	PRP	denotes	we
T7479	1776-1781	DT	denotes	these
T7480	1790-1797	NNS	denotes	regions
T7481	1782-1789	JJ	denotes	genomic
T7482	1798-1800	TO	denotes	to
T7483	1801-1807	VB	denotes	search
T7484	1808-1815	IN	denotes	whether
T7485	1898-1904	VBN	denotes	linked
T7486	1816-1820	PRP	denotes	they
T7487	1820-1822	,	denotes	,
T7488	1822-1824	CC	denotes	or
T7489	1825-1830	PRP$	denotes	their
T7490	1848-1855	NNS	denotes	regions
T7491	1831-1839	JJ	denotes	syntenic
T7492	1840-1847	JJ	denotes	genomic
T7493	1856-1858	IN	denotes	on
T7494	1859-1862	DT	denotes	the
T7495	1869-1875	NN	denotes	genome
T7496	1863-1868	JJ	denotes	human
T7497	1875-1877	,	denotes	,
T7498	1877-1881	VBP	denotes	have
T7499	1882-1886	VBN	denotes	been
T7500	1887-1897	RB	denotes	previously
T7501	1905-1907	IN	denotes	to
T7502	1908-1917	NN	denotes	arthritis
T7503	1917-1918	.	denotes	.
T7504	1918-2013	sentence	denotes	Four small-effect QTL overlapped with arthritis QTL on the mouse genome identified previously.
T7505	1919-1923	CD	denotes	Four
T7506	1937-1940	NNS	denotes	QTL
T7507	1924-1929	JJ	denotes	small
T7508	1930-1936	NN	denotes	effect
T7509	1929-1930	HYPH	denotes	-
T7510	1941-1951	VBD	denotes	overlapped
T7511	1952-1956	IN	denotes	with
T7512	1957-1966	NN	denotes	arthritis
T7513	1967-1970	NNS	denotes	QTL
T7514	1971-1973	IN	denotes	on
T7515	1974-1977	DT	denotes	the
T7516	1984-1990	NN	denotes	genome
T7517	1978-1983	NN	denotes	mouse
T7518	1991-2001	VBN	denotes	identified
T7519	2002-2012	RB	denotes	previously
T7520	2012-2013	.	denotes	.
T7521	2013-2124	sentence	denotes	Locus 1 and 2 overlap with Cia13 and Cia14, which control severity of CIA in (DBA/1 × BALB/C) F2 progeny [27].
T7522	2014-2019	NN	denotes	Locus
T7523	2020-2021	CD	denotes	1
T7524	2028-2035	VBP	denotes	overlap
T7525	2022-2025	CC	denotes	and
T7526	2026-2027	CD	denotes	2
T7527	2036-2040	IN	denotes	with
T7528	2041-2046	NN	denotes	Cia13
T7529	2047-2050	CC	denotes	and
T7530	2051-2056	NN	denotes	Cia14
T7531	2056-2058	,	denotes	,
T7532	2058-2063	WDT	denotes	which
T7533	2064-2071	VBP	denotes	control
T7534	2072-2080	NN	denotes	severity
T7535	2081-2083	IN	denotes	of
T7536	2084-2087	NN	denotes	CIA
T7537	2088-2090	IN	denotes	in
T7538	2091-2092	-LRB-	denotes	(
T7539	2092-2095	NN	denotes	DBA
T7540	2111-2118	NN	denotes	progeny
T7541	2095-2096	HYPH	denotes	/
T7542	2096-2097	CD	denotes	1
T7543	2098-2099	SYM	denotes	×
T7544	2100-2104	NN	denotes	BALB
T7545	2105-2106	NN	denotes	C
T7546	2104-2105	HYPH	denotes	/
T7547	2106-2107	-RRB-	denotes	)
T7548	2108-2110	NN	denotes	F2
T7549	2119-2120	-LRB-	denotes	[
T7550	2120-2122	CD	denotes	27
T7551	2122-2123	-RRB-	denotes	]
T7552	2123-2124	.	denotes	.
T7553	2124-2234	sentence	denotes	Locus 5 located on chromosome 10 overlaps with Cia8, which was identified in (DBA/1 × B10.Q) F2 progeny [28].
T7554	2125-2130	NN	denotes	Locus
T7555	2158-2166	VBZ	denotes	overlaps
T7556	2131-2132	CD	denotes	5
T7557	2133-2140	VBN	denotes	located
T7558	2141-2143	IN	denotes	on
T7559	2144-2154	NN	denotes	chromosome
T7560	2155-2157	CD	denotes	10
T7561	2167-2171	IN	denotes	with
T7562	2172-2176	NN	denotes	Cia8
T7563	2176-2178	,	denotes	,
T7564	2178-2183	WDT	denotes	which
T7565	2188-2198	VBN	denotes	identified
T7566	2184-2187	VBD	denotes	was
T7567	2199-2201	IN	denotes	in
T7568	2202-2203	-LRB-	denotes	(
T7569	2203-2206	NN	denotes	DBA
T7570	2221-2228	NN	denotes	progeny
T7571	2206-2207	HYPH	denotes	/
T7572	2207-2208	CD	denotes	1
T7573	2209-2210	SYM	denotes	×
T7574	2211-2216	NN	denotes	B10.Q
T7575	2216-2217	-RRB-	denotes	)
T7576	2218-2220	NN	denotes	F2
T7577	2229-2230	-LRB-	denotes	[
T7578	2230-2232	CD	denotes	28
T7579	2232-2233	-RRB-	denotes	]
T7580	2233-2234	.	denotes	.
T7581	2234-2390	sentence	denotes	Locus 6 overlaps with Pgia7, which controls susceptibility to proteoglycan-induced arthritis (PGIA) and was identified in (BALB/C × DBA/2) F2 progeny [29].
T7582	2235-2240	NN	denotes	Locus
T7583	2243-2251	VBZ	denotes	overlaps
T7584	2241-2242	CD	denotes	6
T7585	2252-2256	IN	denotes	with
T7586	2257-2262	NN	denotes	Pgia7
T7587	2262-2264	,	denotes	,
T7588	2264-2269	WDT	denotes	which
T7589	2270-2278	VBZ	denotes	controls
T7590	2279-2293	NN	denotes	susceptibility
T7591	2294-2296	IN	denotes	to
T7592	2297-2309	NN	denotes	proteoglycan
T7593	2310-2317	VBN	denotes	induced
T7594	2309-2310	HYPH	denotes	-
T7595	2318-2327	NN	denotes	arthritis
T7596	2328-2329	-LRB-	denotes	(
T7597	2329-2333	NN	denotes	PGIA
T7598	2333-2334	-RRB-	denotes	)
T7599	2335-2338	CC	denotes	and
T7600	2339-2342	VBD	denotes	was
T7601	2343-2353	VBN	denotes	identified
T7602	2354-2356	IN	denotes	in
T7603	2357-2358	-LRB-	denotes	(
T7604	2363-2364	NN	denotes	C
T7605	2358-2362	NN	denotes	BALB
T7606	2362-2363	HYPH	denotes	/
T7607	2377-2384	NN	denotes	progeny
T7608	2365-2366	SYM	denotes	×
T7609	2367-2370	NN	denotes	DBA
T7610	2370-2371	HYPH	denotes	/
T7611	2371-2372	CD	denotes	2
T7612	2372-2373	-RRB-	denotes	)
T7613	2374-2376	NN	denotes	F2
T7614	2385-2386	-LRB-	denotes	[
T7615	2386-2388	CD	denotes	29
T7616	2388-2389	-RRB-	denotes	]
T7617	2389-2390	.	denotes	.
T7618	2390-2503	sentence	denotes	The syntenic genomic regions of five small-effect QTL on the human genome have been reported to be linked to RA.
T7619	2391-2394	DT	denotes	The
T7620	2412-2419	NNS	denotes	regions
T7621	2395-2403	JJ	denotes	syntenic
T7622	2404-2411	JJ	denotes	genomic
T7623	2475-2483	VBN	denotes	reported
T7624	2420-2422	IN	denotes	of
T7625	2423-2427	CD	denotes	five
T7626	2441-2444	NNS	denotes	QTL
T7627	2428-2433	JJ	denotes	small
T7628	2434-2440	NN	denotes	effect
T7629	2433-2434	HYPH	denotes	-
T7630	2445-2447	IN	denotes	on
T7631	2448-2451	DT	denotes	the
T7632	2458-2464	NN	denotes	genome
T7633	2452-2457	JJ	denotes	human
T7634	2465-2469	VBP	denotes	have
T7635	2470-2474	VBN	denotes	been
T7636	2484-2486	TO	denotes	to
T7637	2490-2496	VBN	denotes	linked
T7638	2487-2489	VB	denotes	be
T7639	2497-2499	IN	denotes	to
T7640	2500-2502	NN	denotes	RA
T7641	2502-2503	.	denotes	.
T7642	2503-2862	sentence	denotes	These are genomic regions 22q11 and 12p13-q24 on chromosome 22 and 12 (the counterparts of locus 2), 12p13-pter on chromosome 12 (the counterpart of locus 3), 21q22-qter and 10q22-23 on chromosome 21 and 10 (the counterparts of locus 5), 17q21-25 on chromosome 17 (the counterpart of locus 6) and 3q29-qter on chromosome 3 (the counterpart of locus 7) [2,4].
T7643	2504-2509	DT	denotes	These
T7644	2510-2513	VBP	denotes	are
T7645	2514-2521	JJ	denotes	genomic
T7646	2522-2529	NNS	denotes	regions
T7647	2530-2535	NN	denotes	22q11
T7648	2536-2539	CC	denotes	and
T7649	2540-2545	NN	denotes	12p13
T7650	2546-2549	NN	denotes	q24
T7651	2545-2546	HYPH	denotes	-
T7652	2550-2552	IN	denotes	on
T7653	2553-2563	NN	denotes	chromosome
T7654	2564-2566	CD	denotes	22
T7655	2567-2570	CC	denotes	and
T7656	2571-2573	CD	denotes	12
T7657	2574-2575	-LRB-	denotes	(
T7658	2579-2591	NNS	denotes	counterparts
T7659	2575-2578	DT	denotes	the
T7660	2592-2594	IN	denotes	of
T7661	2595-2600	NN	denotes	locus
T7662	2601-2602	CD	denotes	2
T7663	2602-2603	-RRB-	denotes	)
T7664	2603-2605	,	denotes	,
T7665	2605-2610	NN	denotes	12p13
T7666	2611-2615	NN	denotes	pter
T7667	2610-2611	HYPH	denotes	-
T7668	2616-2618	IN	denotes	on
T7669	2619-2629	NN	denotes	chromosome
T7670	2630-2632	CD	denotes	12
T7671	2633-2634	-LRB-	denotes	(
T7672	2638-2649	NN	denotes	counterpart
T7673	2634-2637	DT	denotes	the
T7674	2650-2652	IN	denotes	of
T7675	2653-2658	NN	denotes	locus
T7676	2659-2660	CD	denotes	3
T7677	2660-2661	-RRB-	denotes	)
T7678	2661-2663	,	denotes	,
T7679	2663-2668	NN	denotes	21q22
T7680	2669-2673	NN	denotes	qter
T7681	2668-2669	HYPH	denotes	-
T7682	2674-2677	CC	denotes	and
T7683	2678-2683	NN	denotes	10q22
T7684	2683-2684	HYPH	denotes	-
T7685	2684-2686	CD	denotes	23
T7686	2687-2689	IN	denotes	on
T7687	2690-2700	NN	denotes	chromosome
T7688	2701-2703	CD	denotes	21
T7689	2704-2707	CC	denotes	and
T7690	2708-2710	CD	denotes	10
T7691	2711-2712	-LRB-	denotes	(
T7692	2716-2728	NNS	denotes	counterparts
T7693	2712-2715	DT	denotes	the
T7694	2729-2731	IN	denotes	of
T7695	2732-2737	NN	denotes	locus
T7696	2738-2739	CD	denotes	5
T7697	2739-2740	-RRB-	denotes	)
T7698	2740-2742	,	denotes	,
T7699	2742-2747	NN	denotes	17q21
T7700	2747-2748	HYPH	denotes	-
T7701	2748-2750	CD	denotes	25
T7702	2751-2753	IN	denotes	on
T7703	2754-2764	NN	denotes	chromosome
T7704	2765-2767	CD	denotes	17
T7705	2768-2769	-LRB-	denotes	(
T7706	2773-2784	NN	denotes	counterpart
T7707	2769-2772	DT	denotes	the
T7708	2785-2787	IN	denotes	of
T7709	2788-2793	NN	denotes	locus
T7710	2794-2795	CD	denotes	6
T7711	2795-2796	-RRB-	denotes	)
T7712	2797-2800	CC	denotes	and
T7713	2801-2805	NN	denotes	3q29
T7714	2806-2810	NN	denotes	qter
T7715	2805-2806	HYPH	denotes	-
T7716	2811-2813	IN	denotes	on
T7717	2814-2824	NN	denotes	chromosome
T7718	2825-2826	CD	denotes	3
T7719	2827-2828	-LRB-	denotes	(
T7720	2832-2843	NN	denotes	counterpart
T7721	2828-2831	DT	denotes	the
T7722	2844-2846	IN	denotes	of
T7723	2847-2852	NN	denotes	locus
T7724	2853-2854	CD	denotes	7
T7725	2854-2855	-RRB-	denotes	)
T7726	2856-2857	-LRB-	denotes	[
T7727	2859-2860	CD	denotes	4
T7728	2857-2858	CD	denotes	2
T7729	2858-2859	,	denotes	,
T7730	2860-2861	-RRB-	denotes	]
T7731	2861-2862	.	denotes	.
T8319	2895-2904	VBN	denotes	expressed
T8320	2910-3004	sentence	denotes	We detected the gene expression profiles using three mice per group, which is a small number.
T8321	2911-2913	PRP	denotes	We
T8322	2914-2922	VBD	denotes	detected
T8314	2864-2870	NN	denotes	Strain
T8315	2871-2879	JJ	denotes	specific
T8316	2870-2871	HYPH	denotes	-
T8317	2905-2910	NNS	denotes	genes
T8318	2880-2894	RB	denotes	differentially
T8323	2923-2926	DT	denotes	the
T8324	2943-2951	NNS	denotes	profiles
T8325	2927-2931	NN	denotes	gene
T8326	2932-2942	NN	denotes	expression
T8327	2952-2957	VBG	denotes	using
T8328	2958-2963	CD	denotes	three
T8329	2964-2968	NNS	denotes	mice
T8330	2969-2972	IN	denotes	per
T8331	2973-2978	NN	denotes	group
T8332	2978-2980	,	denotes	,
T8333	2980-2985	WDT	denotes	which
T8334	2986-2988	VBZ	denotes	is
T8335	2989-2990	DT	denotes	a
T8336	2997-3003	NN	denotes	number
T8337	2991-2996	JJ	denotes	small
T8338	3003-3004	.	denotes	.
T8339	3004-3136	sentence	denotes	Being aware of the importance of data reproducibility, we determined the coefficient of variation (CV) to measure data variability.
T8340	3005-3010	VBG	denotes	Being
T8341	3063-3073	VBD	denotes	determined
T8342	3011-3016	JJ	denotes	aware
T8343	3017-3019	IN	denotes	of
T8344	3020-3023	DT	denotes	the
T8345	3024-3034	NN	denotes	importance
T8346	3035-3037	IN	denotes	of
T8347	3038-3042	NNS	denotes	data
T8348	3043-3058	NN	denotes	reproducibility
T8349	3058-3060	,	denotes	,
T8350	3060-3062	PRP	denotes	we
T8351	3074-3077	DT	denotes	the
T8352	3078-3089	NN	denotes	coefficient
T8353	3090-3092	IN	denotes	of
T8354	3093-3102	NN	denotes	variation
T8355	3103-3104	-LRB-	denotes	(
T8356	3104-3106	NN	denotes	CV
T8357	3106-3107	-RRB-	denotes	)
T8358	3108-3110	TO	denotes	to
T8359	3111-3118	VB	denotes	measure
T8360	3119-3123	NNS	denotes	data
T8361	3124-3135	NN	denotes	variability
T8362	3135-3136	.	denotes	.
T8363	3136-3227	sentence	denotes	The CV for each gene on the chip and the mean CV for the entire probe set were calculated.
T8364	3137-3140	DT	denotes	The
T8365	3141-3143	NN	denotes	CV
T8366	3216-3226	VBN	denotes	calculated
T8367	3144-3147	IN	denotes	for
T8368	3148-3152	DT	denotes	each
T8369	3153-3157	NN	denotes	gene
T8370	3158-3160	IN	denotes	on
T8371	3161-3164	DT	denotes	the
T8372	3165-3169	NN	denotes	chip
T8373	3170-3173	CC	denotes	and
T8374	3174-3177	DT	denotes	the
T8375	3183-3185	NN	denotes	CV
T8376	3178-3182	JJ	denotes	mean
T8377	3186-3189	IN	denotes	for
T8378	3190-3193	DT	denotes	the
T8379	3201-3206	NN	denotes	probe
T8380	3194-3200	JJ	denotes	entire
T8381	3207-3210	VBN	denotes	set
T8382	3211-3215	VBD	denotes	were
T8383	3226-3227	.	denotes	.
T8384	3227-3398	sentence	denotes	The mean CV ranged between 18.4% and 25.8% for all experimental groups, and this relatively low CV indicated that these data could be used for further analysis (Table 1).
T8385	3228-3231	DT	denotes	The
T8386	3237-3239	NN	denotes	CV
T8387	3232-3236	JJ	denotes	mean
T8388	3240-3246	VBD	denotes	ranged
T8389	3247-3254	IN	denotes	between
T8390	3255-3259	CD	denotes	18.4
T8391	3259-3260	NN	denotes	%
T8392	3261-3264	CC	denotes	and
T8393	3265-3269	CD	denotes	25.8
T8394	3269-3270	NN	denotes	%
T8395	3271-3274	IN	denotes	for
T8396	3275-3278	DT	denotes	all
T8397	3292-3298	NNS	denotes	groups
T8398	3279-3291	JJ	denotes	experimental
T8399	3298-3300	,	denotes	,
T8400	3300-3303	CC	denotes	and
T8401	3304-3308	DT	denotes	this
T8402	3324-3326	NN	denotes	CV
T8403	3309-3319	RB	denotes	relatively
T8404	3320-3323	JJ	denotes	low
T8405	3327-3336	VBD	denotes	indicated
T8406	3337-3341	IN	denotes	that
T8407	3362-3366	VBN	denotes	used
T8408	3342-3347	DT	denotes	these
T8409	3348-3352	NNS	denotes	data
T8410	3353-3358	MD	denotes	could
T8411	3359-3361	VB	denotes	be
T8412	3367-3370	IN	denotes	for
T8413	3371-3378	JJ	denotes	further
T8414	3379-3387	NN	denotes	analysis
T8415	3388-3389	-LRB-	denotes	(
T8416	3389-3394	NN	denotes	Table
T8417	3395-3396	CD	denotes	1
T8418	3396-3397	-RRB-	denotes	)
T8419	3397-3398	.	denotes	.
T8420	3398-3596	sentence	denotes	To search for strain-specific differentially expressed genes, we performed comparisons of gene expression between the DBA/1 and FVB/N strains at all four phases of CIA, including NC, PI, OA and CA.
T8421	3399-3401	TO	denotes	To
T8422	3402-3408	VB	denotes	search
T8423	3464-3473	VBD	denotes	performed
T8424	3409-3412	IN	denotes	for
T8425	3413-3419	NN	denotes	strain
T8426	3420-3428	JJ	denotes	specific
T8427	3419-3420	HYPH	denotes	-
T8428	3454-3459	NNS	denotes	genes
T8429	3429-3443	RB	denotes	differentially
T8430	3444-3453	VBN	denotes	expressed
T8431	3459-3461	,	denotes	,
T8432	3461-3463	PRP	denotes	we
T8433	3474-3485	NNS	denotes	comparisons
T8434	3486-3488	IN	denotes	of
T8435	3489-3493	NN	denotes	gene
T8436	3494-3504	NN	denotes	expression
T8437	3505-3512	IN	denotes	between
T8438	3513-3516	DT	denotes	the
T8439	3533-3540	NNS	denotes	strains
T8440	3517-3520	NN	denotes	DBA
T8441	3520-3521	HYPH	denotes	/
T8442	3521-3522	CD	denotes	1
T8443	3523-3526	CC	denotes	and
T8444	3527-3530	NN	denotes	FVB
T8445	3531-3532	NN	denotes	N
T8446	3530-3531	HYPH	denotes	/
T8447	3541-3543	IN	denotes	at
T8448	3544-3547	DT	denotes	all
T8449	3553-3559	NNS	denotes	phases
T8450	3548-3552	CD	denotes	four
T8451	3560-3562	IN	denotes	of
T8452	3563-3566	NN	denotes	CIA
T8453	3566-3568	,	denotes	,
T8454	3568-3577	VBG	denotes	including
T8455	3578-3580	NN	denotes	NC
T8456	3580-3582	,	denotes	,
T8457	3582-3584	NN	denotes	PI
T8458	3584-3586	,	denotes	,
T8459	3586-3588	NN	denotes	OA
T8460	3589-3592	CC	denotes	and
T8461	3593-3595	NN	denotes	CA
T8462	3595-3596	.	denotes	.
T8463	3596-3702	sentence	denotes	For the naive mice without immunisation, 361 genes were differentially expressed between the two strains.
T8464	3597-3600	IN	denotes	For
T8465	3668-3677	VBN	denotes	expressed
T8466	3601-3604	DT	denotes	the
T8467	3611-3615	NNS	denotes	mice
T8468	3605-3610	JJ	denotes	naive
T8469	3616-3623	IN	denotes	without
T8470	3624-3636	NN	denotes	immunisation
T8471	3636-3638	,	denotes	,
T8472	3638-3641	CD	denotes	361
T8473	3642-3647	NNS	denotes	genes
T8474	3648-3652	VBD	denotes	were
T8475	3653-3667	RB	denotes	differentially
T8476	3678-3685	IN	denotes	between
T8477	3686-3689	DT	denotes	the
T8478	3694-3701	NNS	denotes	strains
T8479	3690-3693	CD	denotes	two
T8480	3701-3702	.	denotes	.
T8481	3702-3829	sentence	denotes	On day 10 after immunisation, when both strains did not show any sign of the disease, 141 genes were differentially expressed.
T8482	3703-3705	IN	denotes	On
T8483	3819-3828	VBN	denotes	expressed
T8484	3706-3709	NN	denotes	day
T8485	3710-3712	CD	denotes	10
T8486	3713-3718	IN	denotes	after
T8487	3719-3731	NN	denotes	immunisation
T8488	3731-3733	,	denotes	,
T8489	3733-3737	WRB	denotes	when
T8490	3759-3763	VB	denotes	show
T8491	3738-3742	DT	denotes	both
T8492	3743-3750	NNS	denotes	strains
T8493	3751-3754	VBD	denotes	did
T8494	3755-3758	RB	denotes	not
T8495	3764-3767	DT	denotes	any
T8496	3768-3772	NN	denotes	sign
T8497	3773-3775	IN	denotes	of
T8498	3776-3779	DT	denotes	the
T8499	3780-3787	NN	denotes	disease
T8500	3787-3789	,	denotes	,
T8501	3789-3792	CD	denotes	141
T8502	3793-3798	NNS	denotes	genes
T8503	3799-3803	VBD	denotes	were
T8504	3804-3818	RB	denotes	differentially
T8505	3828-3829	.	denotes	.
T8506	3829-3992	sentence	denotes	After DBA/1 mice developed CIA, 184 and 85 differentially expressed genes were identified between these two strains at the onset and chronic phases, respectively.
T8507	3830-3835	IN	denotes	After
T8508	3847-3856	VBD	denotes	developed
T8509	3836-3839	NN	denotes	DBA
T8510	3842-3846	NNS	denotes	mice
T8511	3839-3840	HYPH	denotes	/
T8512	3840-3841	CD	denotes	1
T8513	3909-3919	VBN	denotes	identified
T8514	3857-3860	NN	denotes	CIA
T8515	3860-3862	,	denotes	,
T8516	3862-3865	CD	denotes	184
T8517	3898-3903	NNS	denotes	genes
T8518	3866-3869	CC	denotes	and
T8519	3870-3872	CD	denotes	85
T8520	3873-3887	RB	denotes	differentially
T8521	3888-3897	VBN	denotes	expressed
T8522	3904-3908	VBD	denotes	were
T8523	3920-3927	IN	denotes	between
T8524	3928-3933	DT	denotes	these
T8525	3938-3945	NNS	denotes	strains
T8526	3934-3937	CD	denotes	two
T8527	3946-3948	IN	denotes	at
T8528	3949-3952	DT	denotes	the
T8529	3971-3977	NNS	denotes	phases
T8530	3953-3958	NN	denotes	onset
T8531	3959-3962	CC	denotes	and
T8532	3963-3970	JJ	denotes	chronic
T8533	3977-3979	,	denotes	,
T8534	3979-3991	RB	denotes	respectively
T8535	3991-3992	.	denotes	.
T8536	3992-4160	sentence	denotes	When the lists of the differentially expressed genes at the four phases were merged and overlapping genes were excluded, 509 genes were identified (Additional file 1).
T8537	3993-3997	WRB	denotes	When
T8538	4070-4076	VBN	denotes	merged
T8539	3998-4001	DT	denotes	the
T8540	4002-4007	NNS	denotes	lists
T8541	4008-4010	IN	denotes	of
T8542	4011-4014	DT	denotes	the
T8543	4040-4045	NNS	denotes	genes
T8544	4015-4029	RB	denotes	differentially
T8545	4030-4039	VBN	denotes	expressed
T8546	4046-4048	IN	denotes	at
T8547	4049-4052	DT	denotes	the
T8548	4058-4064	NNS	denotes	phases
T8549	4053-4057	CD	denotes	four
T8550	4065-4069	VBD	denotes	were
T8551	4129-4139	VBN	denotes	identified
T8552	4077-4080	CC	denotes	and
T8553	4081-4092	VBG	denotes	overlapping
T8554	4093-4098	NNS	denotes	genes
T8555	4104-4112	VBN	denotes	excluded
T8556	4099-4103	VBD	denotes	were
T8557	4112-4114	,	denotes	,
T8558	4114-4117	CD	denotes	509
T8559	4118-4123	NNS	denotes	genes
T8560	4124-4128	VBD	denotes	were
T8561	4140-4141	-LRB-	denotes	(
T8562	4152-4156	NN	denotes	file
T8563	4141-4151	JJ	denotes	Additional
T8564	4157-4158	CD	denotes	1
T8565	4158-4159	-RRB-	denotes	)
T8566	4159-4160	.	denotes	.
T8567	4160-4260	sentence	denotes	Twenty-one genes consistently showed differential expression between the two strains at all phases.
T8568	4161-4167	CD	denotes	Twenty
T8569	4168-4171	CD	denotes	one
T8570	4167-4168	HYPH	denotes	-
T8571	4172-4177	NNS	denotes	genes
T8572	4191-4197	VBD	denotes	showed
T8573	4178-4190	RB	denotes	consistently
T8574	4198-4210	JJ	denotes	differential
T8575	4211-4221	NN	denotes	expression
T8576	4222-4229	IN	denotes	between
T8577	4230-4233	DT	denotes	the
T8578	4238-4245	NNS	denotes	strains
T8579	4234-4237	CD	denotes	two
T8580	4246-4248	IN	denotes	at
T8581	4249-4252	DT	denotes	all
T8582	4253-4259	NNS	denotes	phases
T8583	4259-4260	.	denotes	.
T8584	4260-4421	sentence	denotes	Besides these 21 genes, only 3 additional genes were strain-specific differentially expressed during the 3 phases after CIA induction (PI, OA and CA; Figure 1).
T8585	4261-4268	IN	denotes	Besides
T8586	4345-4354	VBN	denotes	expressed
T8587	4269-4274	DT	denotes	these
T8588	4278-4283	NNS	denotes	genes
T8589	4275-4277	CD	denotes	21
T8590	4283-4285	,	denotes	,
T8591	4285-4289	RB	denotes	only
T8592	4303-4308	NNS	denotes	genes
T8593	4290-4291	CD	denotes	3
T8594	4292-4302	JJ	denotes	additional
T8595	4309-4313	VBD	denotes	were
T8596	4314-4320	NN	denotes	strain
T8597	4321-4329	RB	denotes	specific
T8598	4320-4321	HYPH	denotes	-
T8599	4330-4344	RB	denotes	differentially
T8600	4355-4361	IN	denotes	during
T8601	4362-4365	DT	denotes	the
T8602	4368-4374	NNS	denotes	phases
T8603	4366-4367	CD	denotes	3
T8604	4375-4380	IN	denotes	after
T8605	4381-4384	NN	denotes	CIA
T8606	4385-4394	NN	denotes	induction
T8607	4395-4396	-LRB-	denotes	(
T8608	4411-4417	NN	denotes	Figure
T8609	4396-4398	NN	denotes	PI
T8610	4398-4400	,	denotes	,
T8611	4400-4402	NN	denotes	OA
T8612	4403-4406	CC	denotes	and
T8613	4407-4409	NN	denotes	CA
T8614	4409-4410	:	denotes	;
T8615	4418-4419	CD	denotes	1
T8616	4419-4420	-RRB-	denotes	)
T8617	4420-4421	.	denotes	.
T9552	4423-4430	NN	denotes	Disease
T9553	4431-4439	JJ	denotes	specific
T9554	4430-4431	HYPH	denotes	-
T9555	4465-4470	NNS	denotes	genes
T9556	4440-4454	RB	denotes	differentially
T9557	4455-4464	VBN	denotes	expressed
T9558	4470-4644	sentence	denotes	To identify the disease-specific differentially expressed genes in CIA, we detected the genes that were differentially expressed in LNs during CIA in the susceptible strain.
T9559	4471-4473	TO	denotes	To
T9560	4474-4482	VB	denotes	identify
T9561	4546-4554	VBD	denotes	detected
T9562	4483-4486	DT	denotes	the
T9563	4529-4534	NNS	denotes	genes
T9564	4487-4494	NN	denotes	disease
T9565	4495-4503	JJ	denotes	specific
T9566	4494-4495	HYPH	denotes	-
T9567	4504-4518	RB	denotes	differentially
T9568	4519-4528	VBN	denotes	expressed
T9569	4535-4537	IN	denotes	in
T9570	4538-4541	NN	denotes	CIA
T9571	4541-4543	,	denotes	,
T9572	4543-4545	PRP	denotes	we
T9573	4555-4558	DT	denotes	the
T9574	4559-4564	NNS	denotes	genes
T9575	4565-4569	WDT	denotes	that
T9576	4590-4599	VBN	denotes	expressed
T9577	4570-4574	VBD	denotes	were
T9578	4575-4589	RB	denotes	differentially
T9579	4600-4602	IN	denotes	in
T9580	4603-4606	NNS	denotes	LNs
T9581	4607-4613	IN	denotes	during
T9582	4614-4617	NN	denotes	CIA
T9583	4618-4620	IN	denotes	in
T9584	4621-4624	DT	denotes	the
T9585	4637-4643	NN	denotes	strain
T9586	4625-4636	JJ	denotes	susceptible
T9587	4643-4644	.	denotes	.
T9588	4644-4723	sentence	denotes	Three experimental conditions, PI, OA and CA, were compared with the NC group.
T9589	4645-4650	CD	denotes	Three
T9590	4664-4674	NNS	denotes	conditions
T9591	4651-4663	JJ	denotes	experimental
T9592	4696-4704	VBN	denotes	compared
T9593	4674-4676	,	denotes	,
T9594	4676-4678	NN	denotes	PI
T9595	4678-4680	,	denotes	,
T9596	4680-4682	NN	denotes	OA
T9597	4683-4686	CC	denotes	and
T9598	4687-4689	NN	denotes	CA
T9599	4689-4691	,	denotes	,
T9600	4691-4695	VBD	denotes	were
T9601	4705-4709	IN	denotes	with
T9602	4710-4713	DT	denotes	the
T9603	4717-4722	NN	denotes	group
T9604	4714-4716	NN	denotes	NC
T9605	4722-4723	.	denotes	.
T9606	4723-4929	sentence	denotes	On day 10 after immunisation, 102 genes were differentially expressed – most of them were upregulated (78 out of 102) – while at the onset phase of the disease, only 26 genes were differentially expressed.
T9607	4724-4726	IN	denotes	On
T9608	4814-4825	VBN	denotes	upregulated
T9609	4727-4730	NN	denotes	day
T9610	4731-4733	CD	denotes	10
T9611	4734-4739	IN	denotes	after
T9612	4740-4752	NN	denotes	immunisation
T9613	4752-4754	,	denotes	,
T9614	4754-4757	CD	denotes	102
T9615	4758-4763	NNS	denotes	genes
T9616	4784-4793	VBN	denotes	expressed
T9617	4764-4768	VBD	denotes	were
T9618	4769-4783	RB	denotes	differentially
T9619	4794-4795	,	denotes	–
T9620	4796-4800	JJS	denotes	most
T9621	4801-4803	IN	denotes	of
T9622	4804-4808	PRP	denotes	them
T9623	4809-4813	VBD	denotes	were
T9624	4826-4827	-LRB-	denotes	(
T9625	4837-4840	CD	denotes	102
T9626	4827-4829	CD	denotes	78
T9627	4830-4833	IN	denotes	out
T9628	4834-4836	IN	denotes	of
T9629	4840-4841	-RRB-	denotes	)
T9630	4842-4843	,	denotes	–
T9631	4844-4849	IN	denotes	while
T9632	4919-4928	VBN	denotes	expressed
T9633	4850-4852	IN	denotes	at
T9634	4853-4856	DT	denotes	the
T9635	4863-4868	NN	denotes	phase
T9636	4857-4862	NN	denotes	onset
T9637	4869-4871	IN	denotes	of
T9638	4872-4875	DT	denotes	the
T9639	4876-4883	NN	denotes	disease
T9640	4883-4885	,	denotes	,
T9641	4885-4889	RB	denotes	only
T9642	4893-4898	NNS	denotes	genes
T9643	4890-4892	CD	denotes	26
T9644	4899-4903	VBD	denotes	were
T9645	4904-4918	RB	denotes	differentially
T9646	4928-4929	.	denotes	.
T9647	4929-5048	sentence	denotes	At the chronic phase of the disease, 184 differentially expressed genes were identified, with 156 downregulated genes.
T9648	4930-4932	IN	denotes	At
T9649	5007-5017	VBN	denotes	identified
T9650	4933-4936	DT	denotes	the
T9651	4945-4950	NN	denotes	phase
T9652	4937-4944	JJ	denotes	chronic
T9653	4951-4953	IN	denotes	of
T9654	4954-4957	DT	denotes	the
T9655	4958-4965	NN	denotes	disease
T9656	4965-4967	,	denotes	,
T9657	4967-4970	CD	denotes	184
T9658	4996-5001	NNS	denotes	genes
T9659	4971-4985	RB	denotes	differentially
T9660	4986-4995	VBN	denotes	expressed
T9661	5002-5006	VBD	denotes	were
T9662	5017-5019	,	denotes	,
T9663	5019-5023	IN	denotes	with
T9664	5024-5027	CD	denotes	156
T9665	5042-5047	NNS	denotes	genes
T9666	5028-5041	VBN	denotes	downregulated
T9667	5047-5048	.	denotes	.
T9668	5048-5119	sentence	denotes	Only one gene was differentially expressed at all three phases of CIA.
T9669	5049-5053	RB	denotes	Only
T9670	5058-5062	NN	denotes	gene
T9671	5054-5057	CD	denotes	one
T9672	5082-5091	VBN	denotes	expressed
T9673	5063-5066	VBD	denotes	was
T9674	5067-5081	RB	denotes	differentially
T9675	5092-5094	IN	denotes	at
T9676	5095-5098	DT	denotes	all
T9677	5105-5111	NNS	denotes	phases
T9678	5099-5104	CD	denotes	three
T9679	5112-5114	IN	denotes	of
T9680	5115-5118	NN	denotes	CIA
T9681	5118-5119	.	denotes	.
T9682	5119-5267	sentence	denotes	Besides this gene, five, one and six differentially expressed genes were shared by PI with OA, PI with CA and OA with CA, respectively (Figure 2a).
T9683	5120-5127	IN	denotes	Besides
T9684	5193-5199	VBN	denotes	shared
T9685	5128-5132	DT	denotes	this
T9686	5133-5137	NN	denotes	gene
T9687	5137-5139	,	denotes	,
T9688	5139-5143	CD	denotes	five
T9689	5182-5187	NNS	denotes	genes
T9690	5143-5145	,	denotes	,
T9691	5145-5148	CD	denotes	one
T9692	5149-5152	CC	denotes	and
T9693	5153-5156	CD	denotes	six
T9694	5157-5171	RB	denotes	differentially
T9695	5172-5181	VBN	denotes	expressed
T9696	5188-5192	VBD	denotes	were
T9697	5200-5202	IN	denotes	by
T9698	5203-5205	NN	denotes	PI
T9699	5206-5210	IN	denotes	with
T9700	5211-5213	NN	denotes	OA
T9701	5213-5215	,	denotes	,
T9702	5215-5217	NN	denotes	PI
T9703	5218-5222	IN	denotes	with
T9704	5223-5225	NN	denotes	CA
T9705	5226-5229	CC	denotes	and
T9706	5230-5232	NN	denotes	OA
T9707	5233-5237	IN	denotes	with
T9708	5238-5240	NN	denotes	CA
T9709	5240-5242	,	denotes	,
T9710	5242-5254	RB	denotes	respectively
T9711	5255-5256	-LRB-	denotes	(
T9712	5263-5265	NN	denotes	2a
T9713	5256-5262	NN	denotes	Figure
T9714	5265-5266	-RRB-	denotes	)
T9715	5266-5267	.	denotes	.
T9716	5267-5411	sentence	denotes	Taken together, 310 disease-specific differentially expressed genes were differentially regulated during CIA in DBA/1 mice (Additional file 2).
T9717	5268-5273	VBN	denotes	Taken
T9718	5356-5365	VBN	denotes	regulated
T9719	5274-5282	RB	denotes	together
T9720	5282-5284	,	denotes	,
T9721	5284-5287	CD	denotes	310
T9722	5330-5335	NNS	denotes	genes
T9723	5288-5295	NN	denotes	disease
T9724	5296-5304	JJ	denotes	specific
T9725	5295-5296	HYPH	denotes	-
T9726	5305-5319	RB	denotes	differentially
T9727	5320-5329	VBN	denotes	expressed
T9728	5336-5340	VBD	denotes	were
T9729	5341-5355	RB	denotes	differentially
T9730	5366-5372	IN	denotes	during
T9731	5373-5376	NN	denotes	CIA
T9732	5377-5379	IN	denotes	in
T9733	5380-5383	NN	denotes	DBA
T9734	5386-5390	NNS	denotes	mice
T9735	5383-5384	HYPH	denotes	/
T9736	5384-5385	CD	denotes	1
T9737	5391-5392	-LRB-	denotes	(
T9738	5403-5407	NN	denotes	file
T9739	5392-5402	JJ	denotes	Additional
T9740	5408-5409	CD	denotes	2
T9741	5409-5410	-RRB-	denotes	)
T9742	5410-5411	.	denotes	.
T9743	5411-5539	sentence	denotes	To further characterise the gene expression pattern during CIA, we performed hierarchical cluster analysis for these 310 genes.
T9744	5412-5414	TO	denotes	To
T9745	5423-5435	VB	denotes	characterise
T9746	5415-5422	RB	denotes	further
T9747	5479-5488	VBD	denotes	performed
T9748	5436-5439	DT	denotes	the
T9749	5456-5463	NN	denotes	pattern
T9750	5440-5444	NN	denotes	gene
T9751	5445-5455	NN	denotes	expression
T9752	5464-5470	IN	denotes	during
T9753	5471-5474	NN	denotes	CIA
T9754	5474-5476	,	denotes	,
T9755	5476-5478	PRP	denotes	we
T9756	5489-5501	JJ	denotes	hierarchical
T9757	5510-5518	NN	denotes	analysis
T9758	5502-5509	NN	denotes	cluster
T9759	5519-5522	IN	denotes	for
T9760	5523-5528	DT	denotes	these
T9761	5533-5538	NNS	denotes	genes
T9762	5529-5532	CD	denotes	310
T9763	5538-5539	.	denotes	.
T9764	5539-5661	sentence	denotes	Six gene clusters were identified (clusters I to VI, Figure 2b), each with a distinct gene expression pattern during CIA.
T9765	5540-5543	CD	denotes	Six
T9766	5549-5557	NNS	denotes	clusters
T9767	5544-5548	NN	denotes	gene
T9768	5563-5573	VBN	denotes	identified
T9769	5558-5562	VBD	denotes	were
T9770	5574-5575	-LRB-	denotes	(
T9771	5584-5585	CD	denotes	I
T9772	5575-5583	NNS	denotes	clusters
T9773	5586-5588	IN	denotes	to
T9774	5589-5591	CD	denotes	VI
T9775	5591-5593	,	denotes	,
T9776	5593-5599	NN	denotes	Figure
T9777	5600-5602	NN	denotes	2b
T9778	5602-5603	-RRB-	denotes	)
T9779	5603-5605	,	denotes	,
T9780	5605-5609	DT	denotes	each
T9781	5610-5614	IN	denotes	with
T9782	5615-5616	DT	denotes	a
T9783	5642-5649	NN	denotes	pattern
T9784	5617-5625	JJ	denotes	distinct
T9785	5626-5630	NN	denotes	gene
T9786	5631-5641	NN	denotes	expression
T9787	5650-5656	IN	denotes	during
T9788	5657-5660	NN	denotes	CIA
T9789	5660-5661	.	denotes	.
T9790	5661-5755	sentence	denotes	Cluster I contains 16 genes, representing genes that were upregulated after induction of CIA.
T9791	5662-5669	NN	denotes	Cluster
T9792	5672-5680	VBZ	denotes	contains
T9793	5670-5671	CD	denotes	I
T9794	5681-5683	CD	denotes	16
T9795	5684-5689	NNS	denotes	genes
T9796	5689-5691	,	denotes	,
T9797	5691-5703	VBG	denotes	representing
T9798	5704-5709	NNS	denotes	genes
T9799	5710-5714	WDT	denotes	that
T9800	5720-5731	VBN	denotes	upregulated
T9801	5715-5719	VBD	denotes	were
T9802	5732-5737	IN	denotes	after
T9803	5738-5747	NN	denotes	induction
T9804	5748-5750	IN	denotes	of
T9805	5751-5754	NN	denotes	CIA
T9806	5754-5755	.	denotes	.
T9807	5755-5923	sentence	denotes	The expression of these genes reached a peak at the onset phase of the disease and functional clustering results revealed that they are related to the immune response.
T9808	5756-5759	DT	denotes	The
T9809	5760-5770	NN	denotes	expression
T9810	5786-5793	VBD	denotes	reached
T9811	5771-5773	IN	denotes	of
T9812	5774-5779	DT	denotes	these
T9813	5780-5785	NNS	denotes	genes
T9814	5794-5795	DT	denotes	a
T9815	5796-5800	NN	denotes	peak
T9816	5801-5803	IN	denotes	at
T9817	5804-5807	DT	denotes	the
T9818	5814-5819	NN	denotes	phase
T9819	5808-5813	NN	denotes	onset
T9820	5820-5822	IN	denotes	of
T9821	5823-5826	DT	denotes	the
T9822	5827-5834	NN	denotes	disease
T9823	5835-5838	CC	denotes	and
T9824	5839-5849	JJ	denotes	functional
T9825	5861-5868	NNS	denotes	results
T9826	5850-5860	NN	denotes	clustering
T9827	5869-5877	VBD	denotes	revealed
T9828	5878-5882	IN	denotes	that
T9829	5892-5899	VBN	denotes	related
T9830	5883-5887	PRP	denotes	they
T9831	5888-5891	VBP	denotes	are
T9832	5900-5902	IN	denotes	to
T9833	5903-5906	DT	denotes	the
T9834	5914-5922	NN	denotes	response
T9835	5907-5913	JJ	denotes	immune
T9836	5922-5923	.	denotes	.
T9837	5923-6043	sentence	denotes	Cluster II contains 12 genes whose expression was gradually upregulated and reached a peak at the chronic phase of CIA.
T9838	5924-5931	NN	denotes	Cluster
T9839	5935-5943	VBZ	denotes	contains
T9840	5932-5934	CD	denotes	II
T9841	5944-5946	CD	denotes	12
T9842	5947-5952	NNS	denotes	genes
T9843	5953-5958	WP$	denotes	whose
T9844	5959-5969	NN	denotes	expression
T9845	5984-5995	VBN	denotes	upregulated
T9846	5970-5973	VBD	denotes	was
T9847	5974-5983	RB	denotes	gradually
T9848	5996-5999	CC	denotes	and
T9849	6000-6007	VBN	denotes	reached
T9850	6008-6009	DT	denotes	a
T9851	6010-6014	NN	denotes	peak
T9852	6015-6017	IN	denotes	at
T9853	6018-6021	DT	denotes	the
T9854	6030-6035	NN	denotes	phase
T9855	6022-6029	JJ	denotes	chronic
T9856	6036-6038	IN	denotes	of
T9857	6039-6042	NN	denotes	CIA
T9858	6042-6043	.	denotes	.
T9859	6043-6153	sentence	denotes	These genes are mainly related to the immune response, organelle membrane and extracellular region and space.
T9860	6044-6049	DT	denotes	These
T9861	6050-6055	NNS	denotes	genes
T9862	6067-6074	VBN	denotes	related
T9863	6056-6059	VBP	denotes	are
T9864	6060-6066	RB	denotes	mainly
T9865	6075-6077	IN	denotes	to
T9866	6078-6081	DT	denotes	the
T9867	6089-6097	NN	denotes	response
T9868	6082-6088	JJ	denotes	immune
T9869	6097-6099	,	denotes	,
T9870	6099-6108	NN	denotes	organelle
T9871	6109-6117	NN	denotes	membrane
T9872	6118-6121	CC	denotes	and
T9873	6122-6135	JJ	denotes	extracellular
T9874	6136-6142	NN	denotes	region
T9875	6143-6146	CC	denotes	and
T9876	6147-6152	NN	denotes	space
T9877	6152-6153	.	denotes	.
T9878	6153-6227	sentence	denotes	Cluster III contains 78 genes that were only upregulated at the PI phase.
T9879	6154-6161	NN	denotes	Cluster
T9880	6166-6174	VBZ	denotes	contains
T9881	6162-6165	CD	denotes	III
T9882	6175-6177	CD	denotes	78
T9883	6178-6183	NNS	denotes	genes
T9884	6184-6188	WDT	denotes	that
T9885	6199-6210	VBN	denotes	upregulated
T9886	6189-6193	VBD	denotes	were
T9887	6194-6198	RB	denotes	only
T9888	6211-6213	IN	denotes	at
T9889	6214-6217	DT	denotes	the
T9890	6221-6226	NN	denotes	phase
T9891	6218-6220	NN	denotes	PI
T9892	6226-6227	.	denotes	.
T9893	6227-6282	sentence	denotes	These genes are related to the intercellular junction.
T9894	6228-6233	DT	denotes	These
T9895	6234-6239	NNS	denotes	genes
T9896	6244-6251	VBN	denotes	related
T9897	6240-6243	VBP	denotes	are
T9898	6252-6254	IN	denotes	to
T9899	6255-6258	DT	denotes	the
T9900	6273-6281	NN	denotes	junction
T9901	6259-6272	JJ	denotes	intercellular
T9902	6281-6282	.	denotes	.
T9903	6282-6413	sentence	denotes	More than half of the genes (156 of 310) belong to cluster IV and represent genes specifically downregultaed at the chronic phase.
T9904	6283-6287	JJR	denotes	More
T9905	6293-6297	NN	denotes	half
T9906	6288-6292	IN	denotes	than
T9907	6324-6330	VBP	denotes	belong
T9908	6298-6300	IN	denotes	of
T9909	6301-6304	DT	denotes	the
T9910	6305-6310	NNS	denotes	genes
T9911	6311-6312	-LRB-	denotes	(
T9912	6319-6322	CD	denotes	310
T9913	6312-6315	CD	denotes	156
T9914	6316-6318	IN	denotes	of
T9915	6322-6323	-RRB-	denotes	)
T9916	6331-6333	IN	denotes	to
T9917	6334-6341	NN	denotes	cluster
T9918	6342-6344	CD	denotes	IV
T9919	6345-6348	CC	denotes	and
T9920	6349-6358	VBP	denotes	represent
T9921	6359-6364	NNS	denotes	genes
T9922	6365-6377	RB	denotes	specifically
T9923	6378-6391	VBN	denotes	downregultaed
T9924	6392-6394	IN	denotes	at
T9925	6395-6398	DT	denotes	the
T9926	6407-6412	NN	denotes	phase
T9927	6399-6406	JJ	denotes	chronic
T9928	6412-6413	.	denotes	.
T9929	6413-6551	sentence	denotes	These genes are functionally related to lymphocyte proliferation, T cell activation, protein binding as well as the notch signal pathway.
T9930	6414-6419	DT	denotes	These
T9931	6420-6425	NNS	denotes	genes
T9932	6443-6450	VBN	denotes	related
T9933	6426-6429	VBP	denotes	are
T9934	6430-6442	RB	denotes	functionally
T9935	6451-6453	IN	denotes	to
T9936	6454-6464	NN	denotes	lymphocyte
T9937	6465-6478	NN	denotes	proliferation
T9938	6478-6480	,	denotes	,
T9939	6480-6481	NN	denotes	T
T9940	6482-6486	NN	denotes	cell
T9941	6487-6497	NN	denotes	activation
T9942	6497-6499	,	denotes	,
T9943	6499-6506	NN	denotes	protein
T9944	6507-6514	NN	denotes	binding
T9945	6515-6517	RB	denotes	as
T9946	6523-6525	IN	denotes	as
T9947	6518-6522	RB	denotes	well
T9948	6526-6529	DT	denotes	the
T9949	6543-6550	NN	denotes	pathway
T9950	6530-6535	NN	denotes	notch
T9951	6536-6542	NN	denotes	signal
T9952	6550-6551	.	denotes	.
T9953	6551-6613	sentence	denotes	Cluster V contains eight genes downregulated at the PI phase.
T9954	6552-6559	NN	denotes	Cluster
T9955	6562-6570	VBZ	denotes	contains
T9956	6560-6561	CD	denotes	V
T9957	6571-6576	CD	denotes	eight
T9958	6577-6582	NNS	denotes	genes
T9959	6583-6596	VBN	denotes	downregulated
T9960	6597-6599	IN	denotes	at
T9961	6600-6603	DT	denotes	the
T9962	6607-6612	NN	denotes	phase
T9963	6604-6606	NN	denotes	PI
T9964	6612-6613	.	denotes	.
T9965	6613-6673	sentence	denotes	Cluster VI contains 18 genes downregulated at the OA phase.
T9966	6614-6621	NN	denotes	Cluster
T9967	6625-6633	VBZ	denotes	contains
T9968	6622-6624	CD	denotes	VI
T9969	6634-6636	CD	denotes	18
T9970	6637-6642	NNS	denotes	genes
T9971	6643-6656	VBN	denotes	downregulated
T9972	6657-6659	IN	denotes	at
T9973	6660-6663	DT	denotes	the
T9974	6667-6672	NN	denotes	phase
T9975	6664-6666	NN	denotes	OA
T9976	6672-6673	.	denotes	.
T9977	6673-6789	sentence	denotes	The GO term classification showed no functional cluster that was significantly enriched in these two gene clusters.
T9978	6674-6677	DT	denotes	The
T9979	6686-6700	NN	denotes	classification
T9980	6678-6680	NN	denotes	GO
T9981	6681-6685	NN	denotes	term
T9982	6701-6707	VBD	denotes	showed
T9983	6708-6710	DT	denotes	no
T9984	6722-6729	NN	denotes	cluster
T9985	6711-6721	JJ	denotes	functional
T9986	6730-6734	WDT	denotes	that
T9987	6753-6761	VBN	denotes	enriched
T9988	6735-6738	VBD	denotes	was
T9989	6739-6752	RB	denotes	significantly
T9990	6762-6764	IN	denotes	in
T9991	6765-6770	DT	denotes	these
T9992	6780-6788	NNS	denotes	clusters
T9993	6771-6774	CD	denotes	two
T9994	6775-6779	NN	denotes	gene
T9995	6788-6789	.	denotes	.
T10781	6791-6800	NN	denotes	Candidate
T10782	6801-6806	NNS	denotes	genes
T10783	6807-6810	IN	denotes	for
T10784	6811-6814	DT	denotes	the
T10785	6828-6831	NNS	denotes	QTL
T10786	6815-6820	JJ	denotes	small
T10787	6821-6827	NN	denotes	effect
T10788	6820-6821	HYPH	denotes	-
T10789	6832-6834	IN	denotes	of
T10790	6835-6838	NN	denotes	CIA
T10791	6838-7105	sentence	denotes	To identify candidate susceptibility genes for the CIA small-effect QTL, we compared the list of strain-specific differentially expressed genes with the list of disease-specific differentially expressed genes; 117 genes were shared by both lists (Additional file 3).
T10792	6839-6841	TO	denotes	To
T10793	6842-6850	VB	denotes	identify
T10794	6915-6923	VBD	denotes	compared
T10795	6851-6860	NN	denotes	candidate
T10796	6876-6881	NNS	denotes	genes
T10797	6861-6875	NN	denotes	susceptibility
T10798	6882-6885	IN	denotes	for
T10799	6886-6889	DT	denotes	the
T10800	6907-6910	NNS	denotes	QTL
T10801	6890-6893	NN	denotes	CIA
T10802	6894-6899	JJ	denotes	small
T10803	6900-6906	NN	denotes	effect
T10804	6899-6900	HYPH	denotes	-
T10805	6910-6912	,	denotes	,
T10806	6912-6914	PRP	denotes	we
T10807	7064-7070	VBN	denotes	shared
T10808	6924-6927	DT	denotes	the
T10809	6928-6932	NN	denotes	list
T10810	6933-6935	IN	denotes	of
T10811	6936-6942	NN	denotes	strain
T10812	6943-6951	JJ	denotes	specific
T10813	6942-6943	HYPH	denotes	-
T10814	6977-6982	NNS	denotes	genes
T10815	6952-6966	RB	denotes	differentially
T10816	6967-6976	VBN	denotes	expressed
T10817	6983-6987	IN	denotes	with
T10818	6988-6991	DT	denotes	the
T10819	6992-6996	NN	denotes	list
T10820	6997-6999	IN	denotes	of
T10821	7000-7007	NN	denotes	disease
T10822	7008-7016	JJ	denotes	specific
T10823	7007-7008	HYPH	denotes	-
T10824	7042-7047	NNS	denotes	genes
T10825	7017-7031	RB	denotes	differentially
T10826	7032-7041	VBN	denotes	expressed
T10827	7047-7048	:	denotes	;
T10828	7049-7052	CD	denotes	117
T10829	7053-7058	NNS	denotes	genes
T10830	7059-7063	VBD	denotes	were
T10831	7071-7073	IN	denotes	by
T10832	7074-7078	DT	denotes	both
T10833	7079-7084	NNS	denotes	lists
T10834	7085-7086	-LRB-	denotes	(
T10835	7097-7101	NN	denotes	file
T10836	7086-7096	JJ	denotes	Additional
T10837	7102-7103	CD	denotes	3
T10838	7103-7104	-RRB-	denotes	)
T10839	7104-7105	.	denotes	.
T10840	7105-7219	sentence	denotes	Figure 3 visualises positions of the 117 genes retrieved from Ensembl [30] in relation to the 8 small-effect QTL.
T10841	7106-7112	NN	denotes	Figure
T10842	7115-7125	VBZ	denotes	visualises
T10843	7113-7114	CD	denotes	3
T10844	7126-7135	NNS	denotes	positions
T10845	7136-7138	IN	denotes	of
T10846	7139-7142	DT	denotes	the
T10847	7147-7152	NNS	denotes	genes
T10848	7143-7146	CD	denotes	117
T10849	7153-7162	VBN	denotes	retrieved
T10850	7163-7167	IN	denotes	from
T10851	7168-7175	NNP	denotes	Ensembl
T10852	7176-7177	-LRB-	denotes	[
T10853	7177-7179	CD	denotes	30
T10854	7179-7180	-RRB-	denotes	]
T10855	7181-7183	IN	denotes	in
T10856	7184-7192	NN	denotes	relation
T10857	7193-7195	IN	denotes	to
T10858	7196-7199	DT	denotes	the
T10859	7215-7218	NNS	denotes	QTL
T10860	7200-7201	CD	denotes	8
T10861	7202-7207	JJ	denotes	small
T10862	7208-7214	NN	denotes	effect
T10863	7207-7208	HYPH	denotes	-
T10864	7218-7219	.	denotes	.
T10865	7219-7293	sentence	denotes	The eight loci were located on 7 chromosomes, 5, 6, 7, 10, 11, 16 and 17.
T10866	7220-7223	DT	denotes	The
T10867	7230-7234	NNS	denotes	loci
T10868	7224-7229	CD	denotes	eight
T10869	7240-7247	VBN	denotes	located
T10870	7235-7239	VBD	denotes	were
T10871	7248-7250	IN	denotes	on
T10872	7251-7252	CD	denotes	7
T10873	7253-7264	NNS	denotes	chromosomes
T10874	7264-7266	,	denotes	,
T10875	7266-7267	CD	denotes	5
T10876	7267-7269	,	denotes	,
T10877	7269-7270	CD	denotes	6
T10878	7270-7272	,	denotes	,
T10879	7272-7273	CD	denotes	7
T10880	7273-7275	,	denotes	,
T10881	7275-7277	CD	denotes	10
T10882	7277-7279	,	denotes	,
T10883	7279-7281	CD	denotes	11
T10884	7281-7283	,	denotes	,
T10885	7283-7285	CD	denotes	16
T10886	7286-7289	CC	denotes	and
T10887	7290-7292	CD	denotes	17
T10888	7292-7293	.	denotes	.
T10889	7293-7424	sentence	denotes	Since the confidence intervals of QTL in F2 progeny are around 20 cM [26], we used 40 Mb as the confidence intervals for all loci.
T10890	7294-7299	IN	denotes	Since
T10891	7346-7349	VBP	denotes	are
T10892	7300-7303	DT	denotes	the
T10893	7315-7324	NNS	denotes	intervals
T10894	7304-7314	NN	denotes	confidence
T10895	7325-7327	IN	denotes	of
T10896	7328-7331	NNS	denotes	QTL
T10897	7332-7334	IN	denotes	in
T10898	7335-7337	NN	denotes	F2
T10899	7338-7345	NN	denotes	progeny
T10900	7372-7376	VBD	denotes	used
T10901	7350-7356	IN	denotes	around
T10902	7357-7359	CD	denotes	20
T10903	7360-7362	NN	denotes	cM
T10904	7363-7364	-LRB-	denotes	[
T10905	7364-7366	CD	denotes	26
T10906	7366-7367	-RRB-	denotes	]
T10907	7367-7369	,	denotes	,
T10908	7369-7371	PRP	denotes	we
T10909	7377-7379	CD	denotes	40
T10910	7380-7382	NN	denotes	Mb
T10911	7383-7385	IN	denotes	as
T10912	7386-7389	DT	denotes	the
T10913	7401-7410	NNS	denotes	intervals
T10914	7390-7400	NN	denotes	confidence
T10915	7411-7414	IN	denotes	for
T10916	7415-7418	DT	denotes	all
T10917	7419-7423	NNS	denotes	loci
T10918	7423-7424	.	denotes	.
T10919	7424-7507	sentence	denotes	Twenty-one genes were located in the confidence intervals of six of the eight QTL.
T10920	7425-7431	CD	denotes	Twenty
T10921	7432-7435	CD	denotes	one
T10922	7431-7432	HYPH	denotes	-
T10923	7436-7441	NNS	denotes	genes
T10924	7447-7454	VBN	denotes	located
T10925	7442-7446	VBD	denotes	were
T10926	7455-7457	IN	denotes	in
T10927	7458-7461	DT	denotes	the
T10928	7473-7482	NNS	denotes	intervals
T10929	7462-7472	NN	denotes	confidence
T10930	7483-7485	IN	denotes	of
T10931	7486-7489	CD	denotes	six
T10932	7497-7502	CD	denotes	eight
T10933	7490-7492	IN	denotes	of
T10934	7493-7496	DT	denotes	the
T10935	7503-7506	NNS	denotes	QTL
T10936	7506-7507	.	denotes	.
T10937	7507-7696	sentence	denotes	We located 5, 4, 2, 1, 3 and 6 potential candidate genes within the confidence intervals of loci 1, 2, 3, 5, 6 and 8, respectively, while no candidate gene was identified for loci 4 and 7.
T10938	7508-7510	PRP	denotes	We
T10939	7511-7518	VBD	denotes	located
T10940	7519-7520	CD	denotes	5
T10941	7559-7564	NNS	denotes	genes
T10942	7520-7522	,	denotes	,
T10943	7522-7523	CD	denotes	4
T10944	7523-7525	,	denotes	,
T10945	7525-7526	CD	denotes	2
T10946	7526-7528	,	denotes	,
T10947	7528-7529	CD	denotes	1
T10948	7529-7531	,	denotes	,
T10949	7531-7532	CD	denotes	3
T10950	7533-7536	CC	denotes	and
T10951	7537-7538	CD	denotes	6
T10952	7539-7548	JJ	denotes	potential
T10953	7549-7558	NN	denotes	candidate
T10954	7565-7571	IN	denotes	within
T10955	7572-7575	DT	denotes	the
T10956	7587-7596	NNS	denotes	intervals
T10957	7576-7586	NN	denotes	confidence
T10958	7597-7599	IN	denotes	of
T10959	7600-7604	NNS	denotes	loci
T10960	7605-7606	CD	denotes	1
T10961	7606-7608	,	denotes	,
T10962	7608-7609	CD	denotes	2
T10963	7609-7611	,	denotes	,
T10964	7611-7612	CD	denotes	3
T10965	7612-7614	,	denotes	,
T10966	7614-7615	CD	denotes	5
T10967	7615-7617	,	denotes	,
T10968	7617-7618	CD	denotes	6
T10969	7619-7622	CC	denotes	and
T10970	7623-7624	CD	denotes	8
T10971	7624-7626	,	denotes	,
T10972	7626-7638	RB	denotes	respectively
T10973	7638-7640	,	denotes	,
T10974	7640-7645	IN	denotes	while
T10975	7668-7678	VBN	denotes	identified
T10976	7646-7648	DT	denotes	no
T10977	7659-7663	NN	denotes	gene
T10978	7649-7658	NN	denotes	candidate
T10979	7664-7667	VBD	denotes	was
T10980	7679-7682	IN	denotes	for
T10981	7683-7687	NNS	denotes	loci
T10982	7688-7689	CD	denotes	4
T10983	7690-7693	CC	denotes	and
T10984	7694-7695	CD	denotes	7
T10985	7695-7696	.	denotes	.
T10986	7696-7764	sentence	denotes	Table 3 summarises the 21 candidate genes identified in this study.
T10987	7697-7702	NN	denotes	Table
T10988	7705-7715	VBZ	denotes	summarises
T10989	7703-7704	CD	denotes	3
T10990	7716-7719	DT	denotes	the
T10991	7733-7738	NNS	denotes	genes
T10992	7720-7722	CD	denotes	21
T10993	7723-7732	NN	denotes	candidate
T10994	7739-7749	VBN	denotes	identified
T10995	7750-7752	IN	denotes	in
T10996	7753-7757	DT	denotes	this
T10997	7758-7763	NN	denotes	study
T10998	7763-7764	.	denotes	.
T10999	7764-7881	sentence	denotes	Two genes, hspa1a and Oas1a, were upregulated at the OA phase of CIA and Oas1a was also upregulated at the PI phase.
T11000	7765-7768	CD	denotes	Two
T11001	7769-7774	NNS	denotes	genes
T11002	7799-7810	VBN	denotes	upregulated
T11003	7774-7776	,	denotes	,
T11004	7776-7782	NN	denotes	hspa1a
T11005	7783-7786	CC	denotes	and
T11006	7787-7792	NN	denotes	Oas1a
T11007	7792-7794	,	denotes	,
T11008	7794-7798	VBD	denotes	were
T11009	7811-7813	IN	denotes	at
T11010	7814-7817	DT	denotes	the
T11011	7821-7826	NN	denotes	phase
T11012	7818-7820	NN	denotes	OA
T11013	7827-7829	IN	denotes	of
T11014	7830-7833	NN	denotes	CIA
T11015	7834-7837	CC	denotes	and
T11016	7838-7843	NN	denotes	Oas1a
T11017	7853-7864	VBN	denotes	upregulated
T11018	7844-7847	VBD	denotes	was
T11019	7848-7852	RB	denotes	also
T11020	7865-7867	IN	denotes	at
T11021	7868-7871	DT	denotes	the
T11022	7875-7880	NN	denotes	phase
T11023	7872-7874	NN	denotes	PI
T11024	7880-7881	.	denotes	.
T11025	7881-7976	sentence	denotes	Except for these two genes, all other 19 genes were downregulated at the chronic phase of CIA.
T11026	7882-7888	IN	denotes	Except
T11027	7934-7947	VBN	denotes	downregulated
T11028	7889-7892	IN	denotes	for
T11029	7893-7898	DT	denotes	these
T11030	7903-7908	NNS	denotes	genes
T11031	7899-7902	CD	denotes	two
T11032	7908-7910	,	denotes	,
T11033	7910-7913	DT	denotes	all
T11034	7923-7928	NNS	denotes	genes
T11035	7914-7919	JJ	denotes	other
T11036	7920-7922	CD	denotes	19
T11037	7929-7933	VBD	denotes	were
T11038	7948-7950	IN	denotes	at
T11039	7951-7954	DT	denotes	the
T11040	7963-7968	NN	denotes	phase
T11041	7955-7962	JJ	denotes	chronic
T11042	7969-7971	IN	denotes	of
T11043	7972-7975	NN	denotes	CIA
T11044	7975-7976	.	denotes	.
T11045	7976-8073	sentence	denotes	All genes, except hspa1a, showed expression differences between the two strains at the NC phase.
T11046	7977-7980	DT	denotes	All
T11047	7981-7986	NNS	denotes	genes
T11048	8003-8009	VBD	denotes	showed
T11049	7986-7988	,	denotes	,
T11050	7988-7994	IN	denotes	except
T11051	7995-8001	NN	denotes	hspa1a
T11052	8001-8003	,	denotes	,
T11053	8010-8020	NN	denotes	expression
T11054	8021-8032	NNS	denotes	differences
T11055	8033-8040	IN	denotes	between
T11056	8041-8044	DT	denotes	the
T11057	8049-8056	NNS	denotes	strains
T11058	8045-8048	CD	denotes	two
T11059	8057-8059	IN	denotes	at
T11060	8060-8063	DT	denotes	the
T11061	8067-8072	NN	denotes	phase
T11062	8064-8066	NN	denotes	NC
T11063	8072-8073	.	denotes	.
T11064	8073-8185	sentence	denotes	Five genes were differentially expressed at all phases of CIA, including H2-Q10, Mapk14, Pscd1, Kpnb1 and Wdr1.
T11065	8074-8078	CD	denotes	Five
T11066	8079-8084	NNS	denotes	genes
T11067	8105-8114	VBN	denotes	expressed
T11068	8085-8089	VBD	denotes	were
T11069	8090-8104	RB	denotes	differentially
T11070	8115-8117	IN	denotes	at
T11071	8118-8121	DT	denotes	all
T11072	8122-8128	NNS	denotes	phases
T11073	8129-8131	IN	denotes	of
T11074	8132-8135	NN	denotes	CIA
T11075	8135-8137	,	denotes	,
T11076	8137-8146	VBG	denotes	including
T11077	8147-8149	NN	denotes	H2
T11078	8150-8153	NN	denotes	Q10
T11079	8149-8150	HYPH	denotes	-
T11080	8153-8155	,	denotes	,
T11081	8155-8161	NN	denotes	Mapk14
T11082	8161-8163	,	denotes	,
T11083	8163-8168	NN	denotes	Pscd1
T11084	8168-8170	,	denotes	,
T11085	8170-8175	NN	denotes	Kpnb1
T11086	8176-8179	CC	denotes	and
T11087	8180-8184	NN	denotes	Wdr1
T11088	8184-8185	.	denotes	.
T11089	8185-8469	sentence	denotes	Among these five genes, H2-Q10 had a consistently higher expression in the DBA/1 than the FVB/N strain in all CIA phases, while the other four genes had a higher expression in the DBA/1 strain at the early stages, including NC, PI and OA, but a lower expression at the chronic phase.
T11090	8186-8191	IN	denotes	Among
T11091	8217-8220	VBD	denotes	had
T11092	8192-8197	DT	denotes	these
T11093	8203-8208	NNS	denotes	genes
T11094	8198-8202	CD	denotes	five
T11095	8208-8210	,	denotes	,
T11096	8210-8212	NN	denotes	H2
T11097	8213-8216	NN	denotes	Q10
T11098	8212-8213	HYPH	denotes	-
T11099	8221-8222	DT	denotes	a
T11100	8243-8253	NN	denotes	expression
T11101	8223-8235	RB	denotes	consistently
T11102	8236-8242	JJR	denotes	higher
T11103	8254-8256	IN	denotes	in
T11104	8257-8260	DT	denotes	the
T11105	8261-8264	NN	denotes	DBA
T11106	8264-8265	HYPH	denotes	/
T11107	8265-8266	CD	denotes	1
T11108	8267-8271	IN	denotes	than
T11109	8272-8275	DT	denotes	the
T11110	8282-8288	NN	denotes	strain
T11111	8276-8279	NN	denotes	FVB
T11112	8280-8281	NN	denotes	N
T11113	8279-8280	HYPH	denotes	/
T11114	8289-8291	IN	denotes	in
T11115	8292-8295	DT	denotes	all
T11116	8300-8306	NNS	denotes	phases
T11117	8296-8299	NN	denotes	CIA
T11118	8306-8308	,	denotes	,
T11119	8308-8313	IN	denotes	while
T11120	8335-8338	VBD	denotes	had
T11121	8314-8317	DT	denotes	the
T11122	8329-8334	NNS	denotes	genes
T11123	8318-8323	JJ	denotes	other
T11124	8324-8328	CD	denotes	four
T11125	8339-8340	DT	denotes	a
T11126	8348-8358	NN	denotes	expression
T11127	8341-8347	JJR	denotes	higher
T11128	8359-8361	IN	denotes	in
T11129	8362-8365	DT	denotes	the
T11130	8372-8378	NN	denotes	strain
T11131	8366-8369	NN	denotes	DBA
T11132	8369-8370	HYPH	denotes	/
T11133	8370-8371	CD	denotes	1
T11134	8379-8381	IN	denotes	at
T11135	8382-8385	DT	denotes	the
T11136	8392-8398	NNS	denotes	stages
T11137	8386-8391	JJ	denotes	early
T11138	8398-8400	,	denotes	,
T11139	8400-8409	VBG	denotes	including
T11140	8410-8412	NN	denotes	NC
T11141	8412-8414	,	denotes	,
T11142	8414-8416	NN	denotes	PI
T11143	8417-8420	CC	denotes	and
T11144	8421-8423	NN	denotes	OA
T11145	8423-8425	,	denotes	,
T11146	8425-8428	CC	denotes	but
T11147	8429-8430	DT	denotes	a
T11148	8437-8447	NN	denotes	expression
T11149	8431-8436	JJR	denotes	lower
T11150	8448-8450	IN	denotes	at
T11151	8451-8454	DT	denotes	the
T11152	8463-8468	NN	denotes	phase
T11153	8455-8462	JJ	denotes	chronic
T11154	8468-8469	.	denotes	.
T11155	8469-8618	sentence	denotes	GO term classification analysis revealed that the functional cluster of protein kinase cascade was significantly enriched in the 21 candidate genes.
T11156	8470-8472	NN	denotes	GO
T11157	8493-8501	NN	denotes	analysis
T11158	8473-8477	NN	denotes	term
T11159	8478-8492	NN	denotes	classification
T11160	8502-8510	VBD	denotes	revealed
T11161	8511-8515	IN	denotes	that
T11162	8583-8591	VBN	denotes	enriched
T11163	8516-8519	DT	denotes	the
T11164	8531-8538	NN	denotes	cluster
T11165	8520-8530	JJ	denotes	functional
T11166	8539-8541	IN	denotes	of
T11167	8542-8549	NN	denotes	protein
T11168	8557-8564	NN	denotes	cascade
T11169	8550-8556	NN	denotes	kinase
T11170	8565-8568	VBD	denotes	was
T11171	8569-8582	RB	denotes	significantly
T11172	8592-8594	IN	denotes	in
T11173	8595-8598	DT	denotes	the
T11174	8612-8617	NNS	denotes	genes
T11175	8599-8601	CD	denotes	21
T11176	8602-8611	NN	denotes	candidate
T11177	8617-8618	.	denotes	.
T11178	8618-8710	sentence	denotes	This functional cluster contained four genes, including Mapk14, Mapk8ip3, Stat5a and Gna12.
T11179	8619-8623	DT	denotes	This
T11180	8635-8642	NN	denotes	cluster
T11181	8624-8634	JJ	denotes	functional
T11182	8643-8652	VBD	denotes	contained
T11183	8653-8657	CD	denotes	four
T11184	8658-8663	NNS	denotes	genes
T11185	8663-8665	,	denotes	,
T11186	8665-8674	VBG	denotes	including
T11187	8675-8681	NN	denotes	Mapk14
T11188	8681-8683	,	denotes	,
T11189	8683-8691	NN	denotes	Mapk8ip3
T11190	8691-8693	,	denotes	,
T11191	8693-8699	NN	denotes	Stat5a
T11192	8700-8703	CC	denotes	and
T11193	8704-8709	NN	denotes	Gna12
T11194	8709-8710	.	denotes	.
R1824	T7078	T7079	amod	Small,effect
R1825	T7079	T7081	compound	effect,QTL
R1826	T7080	T7079	punct	-,effect
R1827	T7082	T7081	prep	of,QTL
R1828	T7083	T7082	pobj	CIA,of
R1829	T7084	T7081	prep	in,QTL
R1830	T7085	T7086	punct	(,DBA
R1831	T7086	T7087	nmod	DBA,progeny
R1832	T7087	T7084	pobj	progeny,in
R1833	T7088	T7086	punct	/,DBA
R1834	T7089	T7086	nummod	1,DBA
R1835	T7090	T7086	punct	×,DBA
R1836	T7091	T7092	compound	FVB,N
R1837	T7092	T7086	appos	N,DBA
R1838	T7093	T7092	punct	/,N
R1839	T7094	T7086	punct	),DBA
R1840	T7095	T7087	compound	F2,progeny
R1841	T7097	T7098	prep	In,carried
R1842	T7099	T7100	det	a,study
R1843	T7100	T7097	pobj	study,In
R1844	T7101	T7100	amod	previous,study
R1845	T7102	T7098	punct	", ",carried
R1846	T7103	T7098	nsubj	we,carried
R1847	T7104	T7098	prt	out,carried
R1848	T7105	T7106	det	a,screen
R1849	T7106	T7098	dobj	screen,carried
R1850	T7107	T7106	compound	genome,screen
R1851	T7108	T7109	aux	to,identify
R1852	T7109	T7098	advcl	identify,carried
R1853	T7110	T7109	dobj	QTL,identify
R1854	T7111	T7110	acl	controlling,QTL
R1855	T7112	T7113	compound	CIA,susceptibility
R1856	T7113	T7111	dobj	susceptibility,controlling
R1857	T7114	T7111	prep	in,controlling
R1858	T7115	T7116	punct	(,DBA
R1859	T7116	T7117	nmod	DBA,progeny
R1860	T7117	T7114	pobj	progeny,in
R1861	T7118	T7116	punct	/,DBA
R1862	T7119	T7116	nummod	1,DBA
R1863	T7120	T7121	punct	×,N
R1864	T7121	T7116	prep	N,DBA
R1865	T7122	T7121	compound	FVB,N
R1866	T7123	T7121	punct	/,N
R1867	T7124	T7116	punct	),DBA
R1868	T7125	T7117	compound	F2,progeny
R1869	T7126	T7098	punct	.,carried
R1870	T7128	T7129	prep	For,identified
R1871	T7130	T7131	det	the,phenotype
R1872	T7131	T7128	pobj	phenotype,For
R1873	T7132	T7131	prep	of,phenotype
R1874	T7133	T7134	compound	arthritis,severity
R1875	T7134	T7132	pobj	severity,of
R1876	T7135	T7129	punct	", ",identified
R1877	T7136	T7137	advmod	only,QTL
R1878	T7137	T7129	nsubjpass	QTL,identified
R1879	T7138	T7137	nummod	one,QTL
R1880	T7139	T7137	punct	", ",QTL
R1881	T7140	T7137	appos	Cia2,QTL
R1882	T7141	T7129	punct	", ",identified
R1883	T7142	T7129	auxpass	was,identified
R1884	T7143	T7129	punct	", ",identified
R1885	T7144	T7129	prep	with,identified
R1886	T7145	T7146	det	a,score
R1887	T7146	T7144	pobj	score,with
R1888	T7147	T7148	advmod	highly,significant
R1889	T7148	T7146	amod	significant,score
R1890	T7149	T7146	nmod	logarithm,score
R1891	T7150	T7149	prep	of,logarithm
R1892	T7151	T7152	det	the,odds
R1893	T7152	T7150	pobj	odds,of
R1894	T7153	T7149	punct	(,logarithm
R1895	T7154	T7149	appos	LOD,logarithm
R1896	T7155	T7146	punct	),score
R1897	T7156	T7146	prep	of,score
R1898	T7157	T7156	pobj	12,of
R1899	T7158	T7159	punct	[,10
R1900	T7159	T7129	parataxis	10,identified
R1901	T7160	T7159	punct	],10
R1902	T7161	T7129	punct	.,identified
R1903	T7163	T7164	advmod	However,contributed
R1904	T7165	T7164	punct	", ",contributed
R1905	T7166	T7164	nsubj	Cia2,contributed
R1906	T7167	T7164	prep	to,contributed
R1907	T7168	T7169	advmod	only,%
R1908	T7169	T7167	pobj	%,to
R1909	T7170	T7169	nummod	16,%
R1910	T7171	T7169	prep	of,%
R1911	T7172	T7173	det	the,variations
R1912	T7173	T7171	pobj	variations,of
R1913	T7174	T7173	compound	phenotype,variations
R1914	T7175	T7164	punct	", ",contributed
R1915	T7176	T7164	advcl	indicating,contributed
R1916	T7177	T7178	mark	that,be
R1918	T7179	T7178	expl	there,be
R1919	T7180	T7178	aux	should,be
R1920	T7181	T7182	det	some,QTL
R1921	T7182	T7178	attr	QTL,be
R1922	T7183	T7184	amod	small,effect
R1923	T7184	T7182	compound	effect,QTL
R1924	T7185	T7184	punct	-,effect
R1925	T7186	T7187	poss	whose,contributions
R1926	T7187	T7188	dep	contributions,were
R1928	T7189	T7187	prep	to,contributions
R1929	T7190	T7189	pobj	CIA,to
R1930	T7191	T7188	neg	not,were
R1931	T7192	T7188	acomp	big,were
R1932	T7193	T7192	advmod	enough,big
R1933	T7194	T7195	aux	to,reach
R1934	T7195	T7192	xcomp	reach,big
R1935	T7196	T7197	det	the,value
R1937	T7198	T7199	amod	significant,threshold
R1938	T7199	T7197	compound	threshold,value
R1939	T7200	T7197	prep	of,value
R1940	T7201	T7200	pobj	linkage,of
R1941	T7202	T7164	punct	.,contributed
R1942	T7204	T7205	aux	To,identify
R1943	T7205	T7206	advcl	identify,reanalyzed
R1944	T7207	T7208	det	these,QTL
R1945	T7208	T7205	dobj	QTL,identify
R1946	T7209	T7208	amod	potential,QTL
R1947	T7210	T7211	amod	small,effect
R1948	T7211	T7208	compound	effect,QTL
R1949	T7212	T7211	punct	-,effect
R1950	T7213	T7206	punct	", ",reanalyzed
R1951	T7214	T7206	nsubj	we,reanalyzed
R1952	T7215	T7216	det	the,data
R1953	T7216	T7206	dobj	data,reanalyzed
R1954	T7217	T7206	advcl	using,reanalyzed
R1955	T7218	T7219	det	a,value
R1957	T7220	T7221	amod	lower,threshold
R1958	T7221	T7219	compound	threshold,value
R1959	T7222	T7219	prep	of,value
R1960	T7223	T7222	pobj	linkage,of
R1961	T7224	T7225	punct	(,0.05
R1963	T7226	T7225	nsubj	P,0.05
R1964	T7227	T7225	punct	=,0.05
R1965	T7228	T7225	punct	),0.05
R1966	T7229	T7206	punct	.,reanalyzed
R1967	T7231	T7232	nsubj	We,reasoned
R1968	T7233	T7234	mark	that,masked
R1969	T7234	T7232	ccomp	masked,reasoned
R1970	T7235	T7236	mark	since,proven
R1971	T7236	T7234	advcl	proven,masked
R1972	T7237	T7238	det	the,gene
R1973	T7238	T7236	nsubjpass	gene,proven
R1974	T7239	T7238	amod	main,gene
R1975	T7240	T7238	compound	candidate,gene
R1976	T7241	T7238	prep	of,gene
R1977	T7242	T7241	pobj	Cia2,of
R1978	T7243	T7238	punct	", ",gene
R1979	T7244	T7245	compound	complement,C5
R1980	T7245	T7238	appos	C5,gene
R1981	T7246	T7245	compound	component,C5
R1982	T7247	T7248	punct	(,Hc
R1983	T7248	T7245	parataxis	Hc,C5
R1984	T7249	T7248	punct	),Hc
R1985	T7250	T7236	punct	", ",proven
R1986	T7251	T7236	auxpass	was,proven
R1987	T7252	T7253	aux	to,be
R1988	T7253	T7236	xcomp	be,proven
R1989	T7254	T7253	acomp	essential,be
R1990	T7255	T7254	prep	for,essential
R1991	T7256	T7257	compound	CIA,development
R1992	T7257	T7255	pobj	development,for
R1993	T7258	T7236	cc	and,proven
R1994	T7259	T7260	mark	because,is
R1995	T7260	T7236	conj	is,proven
R1996	T7261	T7262	det	the,strain
R1997	T7262	T7260	nsubj	strain,is
R1998	T7263	T7264	compound	FVB,N
R1999	T7264	T7262	compound	N,strain
R2000	T7265	T7264	punct	/,N
R2001	T7266	T7267	npadvmod	C5,deficient
R2002	T7267	T7260	acomp	deficient,is
R2003	T7268	T7269	punct	[,25
R2004	T7269	T7260	parataxis	25,is
R2005	T7270	T7269	nummod	10,25
R2006	T7271	T7269	punct	",",25
R2007	T7272	T7269	punct	],25
R2008	T7273	T7234	punct	", ",masked
R2009	T7274	T7275	det	some,QTL
R2011	T7276	T7277	amod	small,effect
R2012	T7277	T7275	compound	effect,QTL
R2013	T7278	T7277	punct	-,effect
R2014	T7279	T7234	aux	might,masked
R2015	T7280	T7234	auxpass	be,masked
R2016	T7281	T7234	agent	by,masked
R2017	T7282	T7281	pobj	Cia2,by
R2018	T7283	T7232	punct	.,reasoned
R2019	T7285	T7286	aux	To,exclude
R2020	T7286	T7287	advcl	exclude,performed
R2021	T7288	T7289	det	the,effect
R2022	T7289	T7286	dobj	effect,exclude
R2023	T7290	T7289	compound	masking,effect
R2024	T7291	T7289	prep	of,effect
R2025	T7292	T7291	pobj	C5,of
R2026	T7293	T7287	punct	", ",performed
R2027	T7294	T7287	nsubj	we,performed
R2028	T7295	T7296	compound	linkage,analysis
R2029	T7296	T7287	dobj	analysis,performed
R2030	T7297	T7287	prep	with,performed
R2031	T7298	T7299	nummod	3,datasets
R2032	T7299	T7297	pobj	datasets,with
R2033	T7300	T7287	punct	", ",performed
R2034	T7301	T7302	det	the,first
R2035	T7302	T7303	nsubj	first,containing
R2036	T7303	T7287	advcl	containing,performed
R2037	T7304	T7305	det	all,progeny
R2039	T7306	T7305	nummod	290,progeny
R2040	T7307	T7305	compound	F2,progeny
R2041	T7308	T7303	punct	", ",containing
R2042	T7309	T7310	det	the,second
R2043	T7310	T7311	nsubj	second,progeny
R2044	T7311	T7303	conj	progeny,containing
R2045	T7312	T7311	nummod	77,progeny
R2046	T7313	T7311	nmod	C5+,progeny
R2047	T7314	T7313	punct	/,C5+
R2048	T7315	T7313	punct	+,C5+
R2049	T7316	T7311	compound	F2,progeny
R2050	T7317	T7311	cc	and,progeny
R2051	T7318	T7319	det	the,third
R2052	T7319	T7320	nsubj	third,progeny
R2053	T7320	T7311	conj	progeny,progeny
R2054	T7321	T7320	nummod	133,progeny
R2055	T7322	T7320	nmod	C5+,progeny
R2056	T7323	T7322	punct	/,C5+
R2057	T7324	T7322	punct	-,C5+
R2058	T7325	T7320	compound	F2,progeny
R2059	T7326	T7287	punct	.,performed
R2060	T7328	T7329	nummod	Eight,regions
R2061	T7329	T7331	nsubjpass	regions,linked
R2062	T7330	T7329	amod	genomic,regions
R2063	T7332	T7331	auxpass	were,linked
R2064	T7333	T7331	prep	to,linked
R2065	T7334	T7335	det	the,phenotype
R2066	T7335	T7333	pobj	phenotype,to
R2067	T7336	T7335	prep	of,phenotype
R2068	T7337	T7338	compound	CIA,severity
R2069	T7338	T7336	pobj	severity,of
R2070	T7339	T7340	punct	(,Table
R2071	T7340	T7331	parataxis	Table,linked
R2072	T7341	T7342	nmod	loci,1
R2073	T7342	T7340	dep	1,Table
R2074	T7343	T7342	prep	to,1
R2075	T7344	T7343	pobj	8,to
R2076	T7345	T7340	punct	", ",Table
R2077	T7346	T7340	nummod	2,Table
R2078	T7347	T7340	punct	),Table
R2079	T7348	T7331	punct	", ",linked
R2080	T7349	T7350	mark	with,varying
R2082	T7351	T7352	compound	P,values
R2083	T7352	T7350	nsubj	values,varying
R2084	T7353	T7350	prep	between,varying
R2085	T7354	T7353	pobj	0.043,between
R2086	T7355	T7354	cc	and,0.043
R2087	T7356	T7354	conj	0.003,0.043
R2088	T7357	T7331	punct	.,linked
R2089	T7359	T7360	det	These,QTL
R2090	T7360	T7365	nsubjpass	QTL,located
R2091	T7361	T7360	nummod	eight,QTL
R2092	T7362	T7363	amod	small,effect
R2093	T7363	T7360	compound	effect,QTL
R2094	T7364	T7363	punct	-,effect
R2095	T7366	T7365	auxpass	were,located
R2096	T7367	T7365	prep	on,located
R2097	T7368	T7369	nmod	chromosomes,5
R2098	T7369	T7367	pobj	5,on
R2099	T7370	T7369	punct	", ",5
R2100	T7371	T7369	conj	6,5
R2101	T7372	T7371	punct	", ",6
R2102	T7373	T7371	conj	7,6
R2103	T7374	T7373	punct	", ",7
R2104	T7375	T7373	conj	10,7
R2105	T7376	T7375	punct	", ",10
R2106	T7377	T7375	conj	11,10
R2107	T7378	T7377	punct	", ",11
R2108	T7379	T7377	conj	16,11
R2109	T7380	T7379	punct	", ",16
R2110	T7381	T7379	cc	and,16
R2111	T7382	T7379	conj	17,16
R2112	T7383	T7365	punct	.,located
R2113	T7385	T7386	nummod	Five,loci
R2114	T7386	T7387	nsubjpass	loci,identified
R2115	T7388	T7387	auxpass	were,identified
R2116	T7389	T7387	prep	in,identified
R2117	T7390	T7391	advmod	at,two
R2118	T7391	T7393	nummod	two,datasets
R2119	T7392	T7391	advmod	least,two
R2120	T7393	T7389	pobj	datasets,in
R2121	T7394	T7387	punct	.,identified
R2122	T7396	T7397	prep	Of,had
R2123	T7398	T7399	det	the,loci
R2124	T7399	T7396	pobj	loci,Of
R2125	T7400	T7399	nummod	eight,loci
R2126	T7401	T7397	punct	", ",had
R2127	T7402	T7397	nsubj	five,had
R2128	T7403	T7397	dobj	DBA,had
R2129	T7404	T7403	punct	/,DBA
R2130	T7405	T7403	nummod	1,DBA
R2131	T7406	T7397	prep	as,had
R2132	T7407	T7408	det	the,allele
R2133	T7408	T7406	pobj	allele,as
R2134	T7409	T7408	compound	susceptibility,allele
R2135	T7410	T7397	punct	", ",had
R2136	T7411	T7397	cc	and,had
R2137	T7412	T7413	nsubj	three,had
R2138	T7413	T7397	conj	had,had
R2139	T7414	T7415	compound	FVB,N
R2140	T7415	T7413	dobj	N,had
R2141	T7416	T7415	punct	/,N
R2142	T7417	T7413	prep	as,had
R2143	T7418	T7419	det	the,allele
R2144	T7419	T7417	pobj	allele,as
R2145	T7420	T7419	compound	susceptibility,allele
R2146	T7421	T7397	punct	.,had
R2147	T7423	T7424	nsubj	Lander,suggested
R2148	T7425	T7423	cc	and,Lander
R2149	T7426	T7423	conj	Botstein,Lander
R2150	T7427	T7428	punct	[,26
R2151	T7428	T7426	parataxis	26,Botstein
R2152	T7429	T7428	punct	],26
R2153	T7430	T7431	det	a,score
R2154	T7431	T7424	dobj	score,suggested
R2155	T7432	T7431	compound	LOD,score
R2156	T7433	T7431	prep	of,score
R2157	T7434	T7435	quantmod	between,2
R2158	T7435	T7433	pobj	2,of
R2159	T7436	T7435	cc	and,2
R2160	T7437	T7435	conj	3,2
R2161	T7438	T7439	aux	to,ensure
R2162	T7439	T7424	advcl	ensure,suggested
R2163	T7440	T7441	det	an,rate
R2164	T7441	T7439	dobj	rate,ensure
R2165	T7442	T7441	amod	overall,rate
R2166	T7443	T7444	amod	false,positive
R2167	T7444	T7441	amod	positive,rate
R2168	T7445	T7441	prep	of,rate
R2169	T7446	T7447	nummod	5,%
R2170	T7447	T7445	pobj	%,of
R2171	T7448	T7424	punct	", ",suggested
R2172	T7449	T7450	dep	which,means
R2173	T7450	T7424	advcl	means,suggested
R2174	T7451	T7452	mark	that,prevent
R2175	T7452	T7450	ccomp	prevent,means
R2176	T7453	T7452	csubj	using,prevent
R2177	T7454	T7455	det	a,value
R2178	T7455	T7453	dobj	value,using
R2179	T7456	T7455	amod	lower,value
R2180	T7457	T7455	compound	threshold,value
R2181	T7458	T7452	aux	will,prevent
R2182	T7459	T7460	amod	false,negative
R2183	T7460	T7461	amod	negative,QTL
R2184	T7461	T7452	dobj	QTL,prevent
R2185	T7462	T7452	prep	at,prevent
R2186	T7463	T7464	det	the,expense
R2187	T7464	T7462	pobj	expense,at
R2188	T7465	T7464	prep	of,expense
R2189	T7466	T7465	pcomp	increasing,of
R2190	T7467	T7468	amod	false,positive
R2191	T7468	T7469	amod	positive,QTL
R2192	T7469	T7466	dobj	QTL,increasing
R2193	T7470	T7424	punct	.,suggested
R2194	T7472	T7473	advcl	Being,examined
R2195	T7474	T7472	acomp	aware,Being
R2196	T7475	T7474	prep	of,aware
R2197	T7476	T7475	pobj	this,of
R2198	T7477	T7473	punct	", ",examined
R2199	T7478	T7473	nsubj	we,examined
R2200	T7479	T7480	det	these,regions
R2201	T7480	T7473	dobj	regions,examined
R2202	T7481	T7480	amod	genomic,regions
R2203	T7482	T7483	aux	to,search
R2204	T7483	T7473	advcl	search,examined
R2205	T7484	T7485	mark	whether,linked
R2206	T7485	T7483	ccomp	linked,search
R2207	T7486	T7485	nsubjpass	they,linked
R2208	T7487	T7486	punct	", ",they
R2209	T7488	T7486	cc	or,they
R2210	T7489	T7490	poss	their,regions
R2211	T7490	T7486	conj	regions,they
R2212	T7491	T7490	amod	syntenic,regions
R2213	T7492	T7490	amod	genomic,regions
R2214	T7493	T7490	prep	on,regions
R2215	T7494	T7495	det	the,genome
R2216	T7495	T7493	pobj	genome,on
R2217	T7496	T7495	amod	human,genome
R2218	T7497	T7485	punct	", ",linked
R2219	T7498	T7485	aux	have,linked
R2220	T7499	T7485	auxpass	been,linked
R2221	T7500	T7485	advmod	previously,linked
R2222	T7501	T7485	prep	to,linked
R2223	T7502	T7501	pobj	arthritis,to
R2224	T7503	T7473	punct	.,examined
R2225	T7505	T7506	nummod	Four,QTL
R2226	T7506	T7510	nsubj	QTL,overlapped
R2227	T7507	T7508	amod	small,effect
R2228	T7508	T7506	compound	effect,QTL
R2229	T7509	T7508	punct	-,effect
R2230	T7511	T7510	prep	with,overlapped
R2231	T7512	T7513	compound	arthritis,QTL
R2232	T7513	T7511	pobj	QTL,with
R2233	T7514	T7510	prep	on,overlapped
R2234	T7515	T7516	det	the,genome
R2235	T7516	T7514	pobj	genome,on
R2236	T7517	T7516	compound	mouse,genome
R2237	T7518	T7516	acl	identified,genome
R2238	T7519	T7518	advmod	previously,identified
R2239	T7520	T7510	punct	.,overlapped
R2240	T7522	T7523	nmod	Locus,1
R2241	T7523	T7524	nsubj	1,overlap
R2242	T7525	T7523	cc	and,1
R2243	T7526	T7523	conj	2,1
R2244	T7527	T7524	prep	with,overlap
R2245	T7528	T7527	pobj	Cia13,with
R2246	T7529	T7528	cc	and,Cia13
R2247	T7530	T7528	conj	Cia14,Cia13
R2248	T7531	T7528	punct	", ",Cia13
R2249	T7532	T7533	dep	which,control
R2250	T7533	T7528	relcl	control,Cia13
R2251	T7534	T7533	dobj	severity,control
R2252	T7535	T7534	prep	of,severity
R2253	T7536	T7535	pobj	CIA,of
R2254	T7537	T7533	prep	in,control
R2255	T7538	T7539	punct	(,DBA
R2256	T7539	T7540	nmod	DBA,progeny
R2257	T7540	T7537	pobj	progeny,in
R2258	T7541	T7539	punct	/,DBA
R2259	T7542	T7539	nummod	1,DBA
R2260	T7543	T7539	punct	×,DBA
R2261	T7544	T7545	compound	BALB,C
R2262	T7545	T7539	appos	C,DBA
R2263	T7546	T7545	punct	/,C
R2264	T7547	T7539	punct	),DBA
R2265	T7548	T7540	compound	F2,progeny
R2266	T7549	T7550	punct	[,27
R2267	T7550	T7524	parataxis	27,overlap
R2268	T7551	T7550	punct	],27
R2269	T7552	T7524	punct	.,overlap
R2270	T7554	T7555	nsubj	Locus,overlaps
R2271	T7556	T7554	nummod	5,Locus
R2272	T7557	T7554	acl	located,Locus
R2273	T7558	T7557	prep	on,located
R2274	T7559	T7558	pobj	chromosome,on
R2275	T7560	T7559	nummod	10,chromosome
R2276	T7561	T7555	prep	with,overlaps
R2277	T7562	T7561	pobj	Cia8,with
R2278	T7563	T7562	punct	", ",Cia8
R2279	T7564	T7565	dep	which,identified
R2280	T7565	T7562	relcl	identified,Cia8
R2281	T7566	T7565	auxpass	was,identified
R2282	T7567	T7565	prep	in,identified
R2283	T7568	T7569	punct	(,DBA
R2284	T7569	T7570	nmod	DBA,progeny
R2285	T7570	T7567	pobj	progeny,in
R2286	T7571	T7569	punct	/,DBA
R2287	T7572	T7569	nummod	1,DBA
R2288	T7573	T7569	punct	×,DBA
R2289	T7574	T7569	appos	B10.Q,DBA
R2290	T7575	T7570	punct	),progeny
R2291	T7576	T7570	compound	F2,progeny
R2292	T7577	T7578	punct	[,28
R2293	T7578	T7555	parataxis	28,overlaps
R2294	T7579	T7578	punct	],28
R2295	T7580	T7555	punct	.,overlaps
R2296	T7582	T7583	nsubj	Locus,overlaps
R2297	T7584	T7582	nummod	6,Locus
R2298	T7585	T7583	prep	with,overlaps
R2299	T7586	T7585	pobj	Pgia7,with
R2300	T7587	T7586	punct	", ",Pgia7
R2301	T7588	T7589	dep	which,controls
R2302	T7589	T7586	relcl	controls,Pgia7
R2303	T7590	T7589	dobj	susceptibility,controls
R2304	T7591	T7590	prep	to,susceptibility
R2305	T7592	T7593	npadvmod	proteoglycan,induced
R2306	T7593	T7595	amod	induced,arthritis
R2307	T7594	T7593	punct	-,induced
R2308	T7595	T7591	pobj	arthritis,to
R2309	T7596	T7595	punct	(,arthritis
R2310	T7597	T7595	appos	PGIA,arthritis
R2311	T7598	T7589	punct	),controls
R2312	T7599	T7589	cc	and,controls
R2313	T7600	T7601	auxpass	was,identified
R2314	T7601	T7589	conj	identified,controls
R2315	T7602	T7601	prep	in,identified
R2316	T7603	T7604	punct	(,C
R2318	T7605	T7604	nmod	BALB,C
R2319	T7606	T7604	punct	/,C
R2320	T7607	T7602	pobj	progeny,in
R2321	T7608	T7604	punct	×,C
R2322	T7609	T7604	appos	DBA,C
R2323	T7610	T7609	punct	/,DBA
R2324	T7611	T7609	nummod	2,DBA
R2325	T7612	T7604	punct	),C
R2326	T7613	T7607	compound	F2,progeny
R2327	T7614	T7615	punct	[,29
R2328	T7615	T7583	parataxis	29,overlaps
R2329	T7616	T7615	punct	],29
R2330	T7617	T7583	punct	.,overlaps
R2331	T7619	T7620	det	The,regions
R2333	T7621	T7620	amod	syntenic,regions
R2334	T7622	T7620	amod	genomic,regions
R2335	T7624	T7620	prep	of,regions
R2336	T7625	T7626	nummod	five,QTL
R2337	T7626	T7624	pobj	QTL,of
R2338	T7627	T7628	amod	small,effect
R2339	T7628	T7626	compound	effect,QTL
R2340	T7629	T7628	punct	-,effect
R2341	T7630	T7626	prep	on,QTL
R2342	T7631	T7632	det	the,genome
R2343	T7632	T7630	pobj	genome,on
R2344	T7633	T7632	amod	human,genome
R2345	T7634	T7623	aux	have,reported
R2346	T7635	T7623	auxpass	been,reported
R2347	T7636	T7637	aux	to,linked
R2348	T7637	T7623	xcomp	linked,reported
R2349	T7638	T7637	auxpass	be,linked
R2350	T7639	T7637	prep	to,linked
R2351	T7640	T7639	pobj	RA,to
R2352	T7641	T7623	punct	.,reported
R2353	T7643	T7644	nsubj	These,are
R2354	T7645	T7646	amod	genomic,regions
R2355	T7646	T7644	attr	regions,are
R2356	T7647	T7646	appos	22q11,regions
R2357	T7648	T7647	cc	and,22q11
R2358	T7649	T7650	compound	12p13,q24
R2359	T7650	T7647	conj	q24,22q11
R2360	T7651	T7650	punct	-,q24
R2361	T7652	T7646	prep	on,regions
R2362	T7653	T7654	nmod	chromosome,22
R2363	T7654	T7652	pobj	22,on
R2364	T7655	T7654	cc	and,22
R2365	T7656	T7654	conj	12,22
R2366	T7657	T7658	punct	(,counterparts
R2367	T7658	T7646	parataxis	counterparts,regions
R2368	T7659	T7658	det	the,counterparts
R2369	T7660	T7658	prep	of,counterparts
R2370	T7661	T7660	pobj	locus,of
R2371	T7662	T7661	nummod	2,locus
R2372	T7663	T7658	punct	),counterparts
R2373	T7664	T7646	punct	", ",regions
R2374	T7665	T7666	compound	12p13,pter
R2375	T7666	T7646	conj	pter,regions
R2376	T7667	T7666	punct	-,pter
R2377	T7668	T7666	prep	on,pter
R2378	T7669	T7668	pobj	chromosome,on
R2379	T7670	T7669	nummod	12,chromosome
R2380	T7671	T7672	punct	(,counterpart
R2381	T7672	T7666	parataxis	counterpart,pter
R2382	T7673	T7672	det	the,counterpart
R2383	T7674	T7672	prep	of,counterpart
R2384	T7675	T7674	pobj	locus,of
R2385	T7676	T7675	nummod	3,locus
R2386	T7677	T7672	punct	),counterpart
R2387	T7678	T7666	punct	", ",pter
R2388	T7679	T7680	compound	21q22,qter
R2389	T7680	T7666	conj	qter,pter
R2390	T7681	T7680	punct	-,qter
R2391	T7682	T7680	cc	and,qter
R2392	T7683	T7680	conj	10q22,qter
R2393	T7684	T7683	punct	-,10q22
R2394	T7685	T7683	nummod	23,10q22
R2395	T7686	T7680	prep	on,qter
R2396	T7687	T7688	nmod	chromosome,21
R2397	T7688	T7686	pobj	21,on
R2398	T7689	T7688	cc	and,21
R2399	T7690	T7688	conj	10,21
R2400	T7691	T7692	punct	(,counterparts
R2401	T7692	T7680	parataxis	counterparts,qter
R2402	T7693	T7692	det	the,counterparts
R2403	T7694	T7692	prep	of,counterparts
R2404	T7695	T7694	pobj	locus,of
R2405	T7696	T7695	nummod	5,locus
R2406	T7697	T7692	punct	),counterparts
R2407	T7698	T7680	punct	", ",qter
R2408	T7699	T7680	conj	17q21,qter
R2409	T7700	T7699	punct	-,17q21
R2410	T7701	T7699	nummod	25,17q21
R2411	T7702	T7699	prep	on,17q21
R2412	T7703	T7702	pobj	chromosome,on
R2413	T7704	T7703	nummod	17,chromosome
R2414	T7705	T7706	punct	(,counterpart
R2415	T7706	T7699	parataxis	counterpart,17q21
R2416	T7707	T7706	det	the,counterpart
R2417	T7708	T7706	prep	of,counterpart
R2418	T7709	T7708	pobj	locus,of
R2419	T7710	T7709	nummod	6,locus
R2420	T7711	T7706	punct	),counterpart
R2421	T7712	T7699	cc	and,17q21
R2422	T7713	T7714	compound	3q29,qter
R2423	T7714	T7699	conj	qter,17q21
R2424	T7715	T7714	punct	-,qter
R2425	T7716	T7714	prep	on,qter
R2426	T7717	T7716	pobj	chromosome,on
R2427	T7718	T7717	nummod	3,chromosome
R2428	T7719	T7720	punct	(,counterpart
R2429	T7720	T7714	parataxis	counterpart,qter
R2430	T7721	T7720	det	the,counterpart
R2431	T7722	T7720	prep	of,counterpart
R2432	T7723	T7722	pobj	locus,of
R2433	T7724	T7723	nummod	7,locus
R2434	T7725	T7720	punct	),counterpart
R2435	T7726	T7727	punct	[,4
R2437	T7728	T7727	nummod	2,4
R2438	T7729	T7727	punct	",",4
R2439	T7730	T7727	punct	],4
R2440	T7731	T7644	punct	.,are
R2441	T8314	T8315	npadvmod	Strain,specific
R2442	T8315	T8317	amod	specific,genes
R2443	T8316	T8315	punct	-,specific
R2444	T8318	T8319	advmod	differentially,expressed
R2445	T8319	T8317	amod	expressed,genes
R2446	T8321	T8322	nsubj	We,detected
R2447	T8323	T8324	det	the,profiles
R2449	T8325	T8326	compound	gene,expression
R2450	T8326	T8324	compound	expression,profiles
R2451	T8327	T8322	advcl	using,detected
R2452	T8328	T8329	nummod	three,mice
R2453	T8329	T8327	dobj	mice,using
R2454	T8330	T8329	prep	per,mice
R2455	T8331	T8330	pobj	group,per
R2456	T8332	T8329	punct	", ",mice
R2457	T8333	T8334	dep	which,is
R2458	T8334	T8329	relcl	is,mice
R2459	T8335	T8336	det	a,number
R2460	T8336	T8334	attr	number,is
R2461	T8337	T8336	amod	small,number
R2462	T8338	T8322	punct	.,detected
R2463	T8340	T8341	advcl	Being,determined
R2464	T8342	T8340	acomp	aware,Being
R2465	T8343	T8342	prep	of,aware
R2466	T8344	T8345	det	the,importance
R2467	T8345	T8343	pobj	importance,of
R2468	T8346	T8345	prep	of,importance
R2469	T8347	T8348	compound	data,reproducibility
R2470	T8348	T8346	pobj	reproducibility,of
R2471	T8349	T8341	punct	", ",determined
R2472	T8350	T8341	nsubj	we,determined
R2473	T8351	T8352	det	the,coefficient
R2474	T8352	T8341	dobj	coefficient,determined
R2475	T8353	T8352	prep	of,coefficient
R2476	T8354	T8353	pobj	variation,of
R2477	T8355	T8352	punct	(,coefficient
R2478	T8356	T8352	appos	CV,coefficient
R2479	T8357	T8341	punct	),determined
R2480	T8358	T8359	aux	to,measure
R2481	T8359	T8341	advcl	measure,determined
R2482	T8360	T8361	compound	data,variability
R2483	T8361	T8359	dobj	variability,measure
R2484	T8362	T8341	punct	.,determined
R2485	T8364	T8365	det	The,CV
R2486	T8365	T8366	nsubjpass	CV,calculated
R2487	T8367	T8365	prep	for,CV
R2488	T8368	T8369	det	each,gene
R2489	T8369	T8367	pobj	gene,for
R2490	T8370	T8369	prep	on,gene
R2491	T8371	T8372	det	the,chip
R2492	T8372	T8370	pobj	chip,on
R2493	T8373	T8365	cc	and,CV
R2494	T8374	T8375	det	the,CV
R2495	T8375	T8365	conj	CV,CV
R2496	T8376	T8375	amod	mean,CV
R2497	T8377	T8375	prep	for,CV
R2498	T8378	T8379	det	the,probe
R2499	T8379	T8377	pobj	probe,for
R2500	T8380	T8379	amod	entire,probe
R2501	T8381	T8379	amod	set,probe
R2502	T8382	T8366	auxpass	were,calculated
R2503	T8383	T8366	punct	.,calculated
R2504	T8385	T8386	det	The,CV
R2505	T8386	T8388	nsubj	CV,ranged
R2506	T8387	T8386	amod	mean,CV
R2507	T8389	T8388	prep	between,ranged
R2508	T8390	T8391	nummod	18.4,%
R2509	T8391	T8389	pobj	%,between
R2510	T8392	T8391	cc	and,%
R2511	T8393	T8394	nummod	25.8,%
R2512	T8394	T8391	conj	%,%
R2513	T8395	T8388	prep	for,ranged
R2514	T8396	T8397	det	all,groups
R2515	T8397	T8395	pobj	groups,for
R2516	T8398	T8397	amod	experimental,groups
R2517	T8399	T8388	punct	", ",ranged
R2518	T8400	T8388	cc	and,ranged
R2519	T8401	T8402	det	this,CV
R2521	T8403	T8404	advmod	relatively,low
R2522	T8404	T8402	amod	low,CV
R2523	T8405	T8388	conj	indicated,ranged
R2524	T8406	T8407	mark	that,used
R2525	T8407	T8405	ccomp	used,indicated
R2526	T8408	T8409	det	these,data
R2527	T8409	T8407	nsubjpass	data,used
R2528	T8410	T8407	aux	could,used
R2529	T8411	T8407	auxpass	be,used
R2530	T8412	T8407	prep	for,used
R2531	T8413	T8414	amod	further,analysis
R2532	T8414	T8412	pobj	analysis,for
R2533	T8415	T8416	punct	(,Table
R2534	T8416	T8405	parataxis	Table,indicated
R2535	T8417	T8416	nummod	1,Table
R2536	T8418	T8416	punct	),Table
R2537	T8419	T8405	punct	.,indicated
R2538	T8421	T8422	aux	To,search
R2539	T8422	T8423	advcl	search,performed
R2540	T8424	T8422	prep	for,search
R2541	T8425	T8426	npadvmod	strain,specific
R2542	T8426	T8428	amod	specific,genes
R2543	T8427	T8426	punct	-,specific
R2545	T8429	T8430	advmod	differentially,expressed
R2546	T8430	T8428	amod	expressed,genes
R2547	T8431	T8423	punct	", ",performed
R2548	T8432	T8423	nsubj	we,performed
R2549	T8433	T8423	dobj	comparisons,performed
R2550	T8434	T8433	prep	of,comparisons
R2551	T8435	T8436	compound	gene,expression
R2552	T8436	T8434	pobj	expression,of
R2553	T8437	T8433	prep	between,comparisons
R2554	T8438	T8439	det	the,strains
R2555	T8439	T8437	pobj	strains,between
R2556	T8440	T8439	nmod	DBA,strains
R2557	T8441	T8440	punct	/,DBA
R2558	T8442	T8440	nummod	1,DBA
R2559	T8443	T8440	cc	and,DBA
R2560	T8444	T8445	compound	FVB,N
R2561	T8445	T8440	conj	N,DBA
R2562	T8446	T8445	punct	/,N
R2563	T8447	T8423	prep	at,performed
R2564	T8448	T8449	det	all,phases
R2565	T8449	T8447	pobj	phases,at
R2566	T8450	T8449	nummod	four,phases
R2567	T8451	T8449	prep	of,phases
R2568	T8452	T8451	pobj	CIA,of
R2569	T8453	T8449	punct	", ",phases
R2570	T8454	T8449	prep	including,phases
R2571	T8455	T8454	pobj	NC,including
R2572	T8456	T8455	punct	", ",NC
R2573	T8457	T8455	conj	PI,NC
R2574	T8458	T8457	punct	", ",PI
R2575	T8459	T8457	conj	OA,PI
R2576	T8460	T8459	cc	and,OA
R2577	T8461	T8459	conj	CA,OA
R2578	T8462	T8423	punct	.,performed
R2579	T8464	T8465	prep	For,expressed
R2580	T8466	T8467	det	the,mice
R2581	T8467	T8464	pobj	mice,For
R2582	T8468	T8467	amod	naive,mice
R2583	T8469	T8467	prep	without,mice
R2584	T8470	T8469	pobj	immunisation,without
R2585	T8471	T8465	punct	", ",expressed
R2586	T8472	T8473	nummod	361,genes
R2587	T8473	T8465	nsubjpass	genes,expressed
R2588	T8474	T8465	auxpass	were,expressed
R2589	T8475	T8465	advmod	differentially,expressed
R2590	T8476	T8465	prep	between,expressed
R2591	T8477	T8478	det	the,strains
R2592	T8478	T8476	pobj	strains,between
R2593	T8479	T8478	nummod	two,strains
R2594	T8480	T8465	punct	.,expressed
R2595	T8482	T8483	prep	On,expressed
R2596	T8484	T8482	pobj	day,On
R2597	T8485	T8484	nummod	10,day
R2598	T8486	T8484	prep	after,day
R2599	T8487	T8486	pobj	immunisation,after
R2600	T8488	T8484	punct	", ",day
R2601	T8489	T8490	advmod	when,show
R2602	T8490	T8484	relcl	show,day
R2603	T8491	T8492	det	both,strains
R2604	T8492	T8490	nsubj	strains,show
R2605	T8493	T8490	aux	did,show
R2606	T8494	T8490	neg	not,show
R2607	T8495	T8496	det	any,sign
R2608	T8496	T8490	dobj	sign,show
R2609	T8497	T8496	prep	of,sign
R2610	T8498	T8499	det	the,disease
R2611	T8499	T8497	pobj	disease,of
R2612	T8500	T8483	punct	", ",expressed
R2613	T8501	T8502	nummod	141,genes
R2614	T8502	T8483	nsubjpass	genes,expressed
R2615	T8503	T8483	auxpass	were,expressed
R2616	T8504	T8483	advmod	differentially,expressed
R2617	T8505	T8483	punct	.,expressed
R2618	T8507	T8508	mark	After,developed
R2619	T8508	T8513	advcl	developed,identified
R2620	T8509	T8510	nmod	DBA,mice
R2621	T8510	T8508	nsubj	mice,developed
R2622	T8511	T8509	punct	/,DBA
R2623	T8512	T8509	nummod	1,DBA
R2624	T8514	T8508	dobj	CIA,developed
R2625	T8515	T8513	punct	", ",identified
R2626	T8516	T8517	nummod	184,genes
R2627	T8517	T8513	nsubjpass	genes,identified
R2628	T8518	T8516	cc	and,184
R2629	T8519	T8516	conj	85,184
R2630	T8520	T8521	advmod	differentially,expressed
R2631	T8521	T8517	amod	expressed,genes
R2632	T8522	T8513	auxpass	were,identified
R2633	T8523	T8513	prep	between,identified
R2634	T8524	T8525	det	these,strains
R2635	T8525	T8523	pobj	strains,between
R2636	T8526	T8525	nummod	two,strains
R2637	T8527	T8513	prep	at,identified
R2638	T8528	T8529	det	the,phases
R2639	T8529	T8527	pobj	phases,at
R2640	T8530	T8529	nmod	onset,phases
R2641	T8531	T8530	cc	and,onset
R2642	T8532	T8530	conj	chronic,onset
R2643	T8533	T8513	punct	", ",identified
R2644	T8534	T8513	advmod	respectively,identified
R2645	T8535	T8513	punct	.,identified
R2646	T8537	T8538	advmod	When,merged
R2647	T8538	T8551	advcl	merged,identified
R2648	T8539	T8540	det	the,lists
R2649	T8540	T8538	nsubjpass	lists,merged
R2650	T8541	T8540	prep	of,lists
R2651	T8542	T8543	det	the,genes
R2652	T8543	T8541	pobj	genes,of
R2653	T8544	T8545	advmod	differentially,expressed
R2654	T8545	T8543	amod	expressed,genes
R2655	T8546	T8540	prep	at,lists
R2656	T8547	T8548	det	the,phases
R2657	T8548	T8546	pobj	phases,at
R2658	T8549	T8548	nummod	four,phases
R2659	T8550	T8538	auxpass	were,merged
R2660	T8552	T8538	cc	and,merged
R2661	T8553	T8554	amod	overlapping,genes
R2662	T8554	T8555	nsubjpass	genes,excluded
R2663	T8555	T8538	conj	excluded,merged
R2664	T8556	T8555	auxpass	were,excluded
R2665	T8557	T8551	punct	", ",identified
R2666	T8558	T8559	nummod	509,genes
R2667	T8559	T8551	nsubjpass	genes,identified
R2668	T8560	T8551	auxpass	were,identified
R2669	T8561	T8562	punct	(,file
R2670	T8562	T8551	parataxis	file,identified
R2671	T8563	T8562	amod	Additional,file
R2672	T8564	T8562	nummod	1,file
R2673	T8565	T8562	punct	),file
R2674	T8566	T8551	punct	.,identified
R2675	T8568	T8569	compound	Twenty,one
R2676	T8569	T8571	nummod	one,genes
R2677	T8570	T8569	punct	-,one
R2678	T8571	T8572	nsubj	genes,showed
R2679	T8573	T8572	advmod	consistently,showed
R2680	T8574	T8575	amod	differential,expression
R2681	T8575	T8572	dobj	expression,showed
R2682	T8576	T8572	prep	between,showed
R2683	T8577	T8578	det	the,strains
R2684	T8578	T8576	pobj	strains,between
R2685	T8579	T8578	nummod	two,strains
R2686	T8580	T8572	prep	at,showed
R2687	T8581	T8582	det	all,phases
R2688	T8582	T8580	pobj	phases,at
R2689	T8583	T8572	punct	.,showed
R2690	T8585	T8586	prep	Besides,expressed
R2691	T8587	T8588	det	these,genes
R2692	T8588	T8585	pobj	genes,Besides
R2693	T8589	T8588	nummod	21,genes
R2694	T8590	T8586	punct	", ",expressed
R2695	T8591	T8592	advmod	only,genes
R2697	T8593	T8592	nummod	3,genes
R2698	T8594	T8592	amod	additional,genes
R2699	T8595	T8586	auxpass	were,expressed
R2700	T8596	T8597	npadvmod	strain,specific
R2701	T8597	T8586	advmod	specific,expressed
R2702	T8598	T8597	punct	-,specific
R2703	T8599	T8586	advmod	differentially,expressed
R2704	T8600	T8586	prep	during,expressed
R2705	T8601	T8602	det	the,phases
R2706	T8602	T8600	pobj	phases,during
R2707	T8603	T8602	nummod	3,phases
R2708	T8604	T8602	prep	after,phases
R2709	T8605	T8606	compound	CIA,induction
R2710	T8606	T8604	pobj	induction,after
R2711	T8607	T8608	punct	(,Figure
R2712	T8608	T8586	parataxis	Figure,expressed
R2713	T8609	T8608	dep	PI,Figure
R2714	T8610	T8609	punct	", ",PI
R2715	T8611	T8609	conj	OA,PI
R2716	T8612	T8611	cc	and,OA
R2717	T8613	T8611	conj	CA,OA
R2718	T8614	T8608	punct	;,Figure
R2719	T8615	T8608	nummod	1,Figure
R2720	T8616	T8608	punct	),Figure
R2721	T8617	T8586	punct	.,expressed
R2724	T9552	T9553	npadvmod	Disease,specific
R2725	T9553	T9555	amod	specific,genes
R2726	T9554	T9553	punct	-,specific
R2727	T9556	T9557	advmod	differentially,expressed
R2728	T9557	T9555	amod	expressed,genes
R2729	T9559	T9560	aux	To,identify
R2730	T9560	T9561	advcl	identify,detected
R2731	T9562	T9563	det	the,genes
R2732	T9563	T9560	dobj	genes,identify
R2733	T9564	T9565	npadvmod	disease,specific
R2734	T9565	T9563	amod	specific,genes
R2735	T9566	T9565	punct	-,specific
R2736	T9567	T9568	advmod	differentially,expressed
R2737	T9568	T9563	amod	expressed,genes
R2738	T9569	T9560	prep	in,identify
R2739	T9570	T9569	pobj	CIA,in
R2740	T9571	T9561	punct	", ",detected
R2741	T9572	T9561	nsubj	we,detected
R2742	T9573	T9574	det	the,genes
R2743	T9574	T9561	dobj	genes,detected
R2744	T9575	T9576	dep	that,expressed
R2745	T9576	T9574	relcl	expressed,genes
R2746	T9577	T9576	auxpass	were,expressed
R2747	T9578	T9576	advmod	differentially,expressed
R2748	T9579	T9576	prep	in,expressed
R2749	T9580	T9579	pobj	LNs,in
R2750	T9581	T9576	prep	during,expressed
R2751	T9582	T9581	pobj	CIA,during
R2752	T9583	T9576	prep	in,expressed
R2753	T9584	T9585	det	the,strain
R2754	T9585	T9583	pobj	strain,in
R2755	T9586	T9585	amod	susceptible,strain
R2756	T9587	T9561	punct	.,detected
R2757	T9589	T9590	nummod	Three,conditions
R2758	T9590	T9592	nsubjpass	conditions,compared
R2759	T9591	T9590	amod	experimental,conditions
R2760	T9593	T9590	punct	", ",conditions
R2761	T9594	T9590	appos	PI,conditions
R2762	T9595	T9594	punct	", ",PI
R2763	T9596	T9594	conj	OA,PI
R2764	T9597	T9596	cc	and,OA
R2765	T9598	T9596	conj	CA,OA
R2766	T9599	T9592	punct	", ",compared
R2767	T9600	T9592	auxpass	were,compared
R2768	T9601	T9592	prep	with,compared
R2769	T9602	T9603	det	the,group
R2770	T9603	T9601	pobj	group,with
R2771	T9604	T9603	compound	NC,group
R2772	T9605	T9592	punct	.,compared
R2773	T9607	T9608	prep	On,upregulated
R2774	T9609	T9607	pobj	day,On
R2775	T9610	T9609	nummod	10,day
R2776	T9611	T9609	prep	after,day
R2777	T9612	T9611	pobj	immunisation,after
R2778	T9613	T9608	punct	", ",upregulated
R2779	T9614	T9615	nummod	102,genes
R2780	T9615	T9616	nsubjpass	genes,expressed
R2781	T9616	T9608	ccomp	expressed,upregulated
R2782	T9617	T9616	auxpass	were,expressed
R2783	T9618	T9616	advmod	differentially,expressed
R2784	T9619	T9608	punct	–,upregulated
R2785	T9620	T9608	nsubjpass	most,upregulated
R2786	T9621	T9620	prep	of,most
R2787	T9622	T9621	pobj	them,of
R2788	T9623	T9608	auxpass	were,upregulated
R2789	T9624	T9625	punct	(,102
R2790	T9625	T9608	parataxis	102,upregulated
R2791	T9626	T9625	quantmod	78,102
R2792	T9627	T9625	quantmod	out,102
R2793	T9628	T9625	quantmod	of,102
R2794	T9629	T9625	punct	),102
R2795	T9630	T9608	punct	–,upregulated
R2796	T9631	T9632	mark	while,expressed
R2797	T9632	T9608	advcl	expressed,upregulated
R2798	T9633	T9632	prep	at,expressed
R2799	T9634	T9635	det	the,phase
R2800	T9635	T9633	pobj	phase,at
R2801	T9636	T9635	compound	onset,phase
R2802	T9637	T9635	prep	of,phase
R2803	T9638	T9639	det	the,disease
R2804	T9639	T9637	pobj	disease,of
R2805	T9640	T9632	punct	", ",expressed
R2806	T9641	T9642	advmod	only,genes
R2807	T9642	T9632	nsubjpass	genes,expressed
R2808	T9643	T9642	nummod	26,genes
R2809	T9644	T9632	auxpass	were,expressed
R2810	T9645	T9632	advmod	differentially,expressed
R2811	T9646	T9608	punct	.,upregulated
R2812	T9648	T9649	prep	At,identified
R2813	T9650	T9651	det	the,phase
R2814	T9651	T9648	pobj	phase,At
R2815	T9652	T9651	amod	chronic,phase
R2816	T9653	T9651	prep	of,phase
R2817	T9654	T9655	det	the,disease
R2818	T9655	T9653	pobj	disease,of
R2819	T9656	T9649	punct	", ",identified
R2820	T9657	T9658	nummod	184,genes
R2821	T9658	T9649	nsubjpass	genes,identified
R2822	T9659	T9660	advmod	differentially,expressed
R2823	T9660	T9658	amod	expressed,genes
R2824	T9661	T9649	auxpass	were,identified
R2825	T9662	T9649	punct	", ",identified
R2826	T9663	T9649	prep	with,identified
R2827	T9664	T9665	nummod	156,genes
R2828	T9665	T9663	pobj	genes,with
R2829	T9666	T9665	amod	downregulated,genes
R2830	T9667	T9649	punct	.,identified
R2831	T9669	T9670	advmod	Only,gene
R2832	T9670	T9672	nsubjpass	gene,expressed
R2833	T9671	T9670	nummod	one,gene
R2834	T9673	T9672	auxpass	was,expressed
R2835	T9674	T9672	advmod	differentially,expressed
R2836	T9675	T9672	prep	at,expressed
R2837	T9676	T9677	det	all,phases
R2838	T9677	T9675	pobj	phases,at
R2839	T9678	T9677	nummod	three,phases
R2840	T9679	T9677	prep	of,phases
R2841	T9680	T9679	pobj	CIA,of
R2842	T9681	T9672	punct	.,expressed
R2843	T9683	T9684	prep	Besides,shared
R2844	T9685	T9686	det	this,gene
R2845	T9686	T9683	pobj	gene,Besides
R2846	T9687	T9684	punct	", ",shared
R2847	T9688	T9689	nummod	five,genes
R2848	T9689	T9684	nsubjpass	genes,shared
R2849	T9690	T9688	punct	", ",five
R2850	T9691	T9688	conj	one,five
R2851	T9692	T9691	cc	and,one
R2852	T9693	T9691	conj	six,one
R2853	T9694	T9695	advmod	differentially,expressed
R2854	T9695	T9689	amod	expressed,genes
R2855	T9696	T9684	auxpass	were,shared
R2856	T9697	T9684	agent	by,shared
R2857	T9698	T9697	pobj	PI,by
R2858	T9699	T9698	prep	with,PI
R2859	T9700	T9699	pobj	OA,with
R2860	T9701	T9698	punct	", ",PI
R2861	T9702	T9698	conj	PI,PI
R2862	T9703	T9702	prep	with,PI
R2863	T9704	T9703	pobj	CA,with
R2864	T9705	T9702	cc	and,PI
R2865	T9706	T9702	conj	OA,PI
R2866	T9707	T9706	prep	with,OA
R2867	T9708	T9707	pobj	CA,with
R2868	T9709	T9684	punct	", ",shared
R2869	T9710	T9684	advmod	respectively,shared
R2870	T9711	T9712	punct	(,2a
R2871	T9712	T9684	parataxis	2a,shared
R2872	T9713	T9712	compound	Figure,2a
R2873	T9714	T9712	punct	),2a
R2874	T9715	T9684	punct	.,shared
R2875	T9717	T9718	advcl	Taken,regulated
R2876	T9719	T9717	advmod	together,Taken
R2877	T9720	T9718	punct	", ",regulated
R2878	T9721	T9722	nummod	310,genes
R2879	T9722	T9718	nsubjpass	genes,regulated
R2880	T9723	T9724	npadvmod	disease,specific
R2881	T9724	T9722	amod	specific,genes
R2882	T9725	T9724	punct	-,specific
R2883	T9726	T9727	advmod	differentially,expressed
R2884	T9727	T9722	amod	expressed,genes
R2885	T9728	T9718	auxpass	were,regulated
R2886	T9729	T9718	advmod	differentially,regulated
R2887	T9730	T9718	prep	during,regulated
R2888	T9731	T9730	pobj	CIA,during
R2889	T9732	T9718	prep	in,regulated
R2890	T9733	T9734	nmod	DBA,mice
R2891	T9734	T9732	pobj	mice,in
R2892	T9735	T9733	punct	/,DBA
R2893	T9736	T9733	nummod	1,DBA
R2894	T9737	T9738	punct	(,file
R2895	T9738	T9718	parataxis	file,regulated
R2896	T9739	T9738	amod	Additional,file
R2897	T9740	T9738	nummod	2,file
R2898	T9741	T9738	punct	),file
R2899	T9742	T9718	punct	.,regulated
R2900	T9744	T9745	aux	To,characterise
R2901	T9745	T9747	advcl	characterise,performed
R2902	T9746	T9745	advmod	further,characterise
R2903	T9748	T9749	det	the,pattern
R2904	T9749	T9745	dobj	pattern,characterise
R2905	T9750	T9751	compound	gene,expression
R2906	T9751	T9749	compound	expression,pattern
R2907	T9752	T9745	prep	during,characterise
R2908	T9753	T9752	pobj	CIA,during
R2909	T9754	T9747	punct	", ",performed
R2910	T9755	T9747	nsubj	we,performed
R2911	T9756	T9757	amod	hierarchical,analysis
R2912	T9757	T9747	dobj	analysis,performed
R2913	T9758	T9757	compound	cluster,analysis
R2914	T9759	T9747	prep	for,performed
R2915	T9760	T9761	det	these,genes
R2916	T9761	T9759	pobj	genes,for
R2917	T9762	T9761	nummod	310,genes
R2918	T9763	T9747	punct	.,performed
R2919	T9765	T9766	nummod	Six,clusters
R2920	T9766	T9768	nsubjpass	clusters,identified
R2921	T9767	T9766	compound	gene,clusters
R2922	T9769	T9768	auxpass	were,identified
R2923	T9770	T9771	punct	(,I
R2924	T9771	T9768	parataxis	I,identified
R2925	T9772	T9771	nmod	clusters,I
R2926	T9773	T9771	prep	to,I
R2927	T9774	T9773	pobj	VI,to
R2928	T9775	T9771	punct	", ",I
R2929	T9776	T9777	compound	Figure,2b
R2930	T9777	T9771	appos	2b,I
R2931	T9778	T9771	punct	),I
R2932	T9779	T9768	punct	", ",identified
R2933	T9780	T9768	npadvmod	each,identified
R2934	T9781	T9780	prep	with,each
R2935	T9782	T9783	det	a,pattern
R2936	T9783	T9781	pobj	pattern,with
R2937	T9784	T9783	amod	distinct,pattern
R2938	T9785	T9786	compound	gene,expression
R2939	T9786	T9783	compound	expression,pattern
R2940	T9787	T9768	prep	during,identified
R2941	T9788	T9787	pobj	CIA,during
R2942	T9789	T9768	punct	.,identified
R2943	T9791	T9792	nsubj	Cluster,contains
R2944	T9793	T9791	nummod	I,Cluster
R2945	T9794	T9795	nummod	16,genes
R2946	T9795	T9792	dobj	genes,contains
R2947	T9796	T9795	punct	", ",genes
R2948	T9797	T9795	acl	representing,genes
R2949	T9798	T9797	dobj	genes,representing
R2950	T9799	T9800	dep	that,upregulated
R2951	T9800	T9798	relcl	upregulated,genes
R2952	T9801	T9800	auxpass	were,upregulated
R2953	T9802	T9800	prep	after,upregulated
R2954	T9803	T9802	pobj	induction,after
R2955	T9804	T9803	prep	of,induction
R2956	T9805	T9804	pobj	CIA,of
R2957	T9806	T9792	punct	.,contains
R2958	T9808	T9809	det	The,expression
R2959	T9809	T9810	nsubj	expression,reached
R2960	T9811	T9809	prep	of,expression
R2961	T9812	T9813	det	these,genes
R2962	T9813	T9811	pobj	genes,of
R2963	T9814	T9815	det	a,peak
R2964	T9815	T9810	dobj	peak,reached
R2965	T9816	T9810	prep	at,reached
R2966	T9817	T9818	det	the,phase
R2967	T9818	T9816	pobj	phase,at
R2968	T9819	T9818	compound	onset,phase
R2969	T9820	T9818	prep	of,phase
R2970	T9821	T9822	det	the,disease
R2971	T9822	T9820	pobj	disease,of
R2972	T9823	T9810	cc	and,reached
R2973	T9824	T9825	amod	functional,results
R2974	T9825	T9827	nsubj	results,revealed
R2975	T9826	T9825	compound	clustering,results
R2976	T9827	T9810	conj	revealed,reached
R2977	T9828	T9829	mark	that,related
R2978	T9829	T9827	ccomp	related,revealed
R2979	T9830	T9829	nsubjpass	they,related
R2980	T9831	T9829	auxpass	are,related
R2981	T9832	T9829	prep	to,related
R2982	T9833	T9834	det	the,response
R2983	T9834	T9832	pobj	response,to
R2984	T9835	T9834	amod	immune,response
R2985	T9836	T9827	punct	.,revealed
R2986	T9838	T9839	nsubj	Cluster,contains
R2987	T9840	T9838	nummod	II,Cluster
R2988	T9841	T9842	nummod	12,genes
R2989	T9842	T9839	dobj	genes,contains
R2990	T9843	T9844	poss	whose,expression
R2991	T9844	T9845	dep	expression,upregulated
R2992	T9845	T9842	relcl	upregulated,genes
R2993	T9846	T9845	auxpass	was,upregulated
R2994	T9847	T9845	advmod	gradually,upregulated
R2995	T9848	T9845	cc	and,upregulated
R2996	T9849	T9845	conj	reached,upregulated
R2997	T9850	T9851	det	a,peak
R2998	T9851	T9849	dobj	peak,reached
R2999	T9852	T9849	prep	at,reached
R3000	T9853	T9854	det	the,phase
R3001	T9854	T9852	pobj	phase,at
R3002	T9855	T9854	amod	chronic,phase
R3003	T9856	T9854	prep	of,phase
R3004	T9857	T9856	pobj	CIA,of
R3005	T9858	T9839	punct	.,contains
R3006	T9860	T9861	det	These,genes
R3007	T9861	T9862	nsubjpass	genes,related
R3008	T9863	T9862	auxpass	are,related
R3009	T9864	T9862	advmod	mainly,related
R3010	T9865	T9862	prep	to,related
R3011	T9866	T9867	det	the,response
R3012	T9867	T9865	pobj	response,to
R3013	T9868	T9867	amod	immune,response
R3014	T9869	T9867	punct	", ",response
R3015	T9870	T9871	compound	organelle,membrane
R3016	T9871	T9867	conj	membrane,response
R3017	T9872	T9871	cc	and,membrane
R3018	T9873	T9874	amod	extracellular,region
R3019	T9874	T9871	conj	region,membrane
R3020	T9875	T9874	cc	and,region
R3021	T9876	T9874	conj	space,region
R3022	T9877	T9862	punct	.,related
R3023	T9879	T9880	nsubj	Cluster,contains
R3024	T9881	T9879	nummod	III,Cluster
R3025	T9882	T9883	nummod	78,genes
R3026	T9883	T9880	dobj	genes,contains
R3027	T9884	T9885	dep	that,upregulated
R3028	T9885	T9883	relcl	upregulated,genes
R3029	T9886	T9885	auxpass	were,upregulated
R3030	T9887	T9885	advmod	only,upregulated
R3031	T9888	T9885	prep	at,upregulated
R3032	T9889	T9890	det	the,phase
R3033	T9890	T9888	pobj	phase,at
R3034	T9891	T9890	compound	PI,phase
R3035	T9892	T9880	punct	.,contains
R3036	T9894	T9895	det	These,genes
R3037	T9895	T9896	nsubjpass	genes,related
R3038	T9897	T9896	auxpass	are,related
R3039	T9898	T9896	prep	to,related
R3040	T9899	T9900	det	the,junction
R3041	T9900	T9898	pobj	junction,to
R3042	T9901	T9900	amod	intercellular,junction
R3043	T9902	T9896	punct	.,related
R3044	T9904	T9905	amod	More,half
R3045	T9905	T9907	nsubj	half,belong
R3046	T9906	T9905	quantmod	than,half
R3047	T9908	T9905	prep	of,half
R3048	T9909	T9910	det	the,genes
R3049	T9910	T9908	pobj	genes,of
R3050	T9911	T9912	punct	(,310
R3051	T9912	T9905	parataxis	310,half
R3052	T9913	T9912	quantmod	156,310
R3053	T9914	T9912	quantmod	of,310
R3054	T9915	T9912	punct	),310
R3055	T9916	T9907	prep	to,belong
R3056	T9917	T9916	pobj	cluster,to
R3057	T9918	T9917	nummod	IV,cluster
R3058	T9919	T9907	cc	and,belong
R3059	T9920	T9907	conj	represent,belong
R3060	T9921	T9920	dobj	genes,represent
R3061	T9922	T9923	advmod	specifically,downregultaed
R3062	T9923	T9921	acl	downregultaed,genes
R3063	T9924	T9923	prep	at,downregultaed
R3064	T9925	T9926	det	the,phase
R3065	T9926	T9924	pobj	phase,at
R3066	T9927	T9926	amod	chronic,phase
R3067	T9928	T9907	punct	.,belong
R3068	T9930	T9931	det	These,genes
R3069	T9931	T9932	nsubjpass	genes,related
R3070	T9933	T9932	auxpass	are,related
R3071	T9934	T9932	advmod	functionally,related
R3072	T9935	T9932	prep	to,related
R3073	T9936	T9937	compound	lymphocyte,proliferation
R3074	T9937	T9935	pobj	proliferation,to
R3075	T9938	T9937	punct	", ",proliferation
R3076	T9939	T9940	compound	T,cell
R3077	T9940	T9941	compound	cell,activation
R3078	T9941	T9937	appos	activation,proliferation
R3079	T9942	T9937	punct	", ",proliferation
R3080	T9943	T9944	compound	protein,binding
R3081	T9944	T9937	appos	binding,proliferation
R3082	T9945	T9946	advmod	as,as
R3083	T9946	T9937	cc	as,proliferation
R3084	T9947	T9946	advmod	well,as
R3085	T9948	T9949	det	the,pathway
R3086	T9949	T9937	conj	pathway,proliferation
R3087	T9950	T9949	compound	notch,pathway
R3088	T9951	T9949	compound	signal,pathway
R3089	T9952	T9932	punct	.,related
R3090	T9954	T9955	nsubj	Cluster,contains
R3091	T9956	T9954	nummod	V,Cluster
R3092	T9957	T9958	nummod	eight,genes
R3093	T9958	T9955	dobj	genes,contains
R3094	T9959	T9958	acl	downregulated,genes
R3095	T9960	T9959	prep	at,downregulated
R3096	T9961	T9962	det	the,phase
R3097	T9962	T9960	pobj	phase,at
R3098	T9963	T9962	compound	PI,phase
R3099	T9964	T9955	punct	.,contains
R3100	T9966	T9967	nsubj	Cluster,contains
R3101	T9968	T9966	nummod	VI,Cluster
R3102	T9969	T9970	nummod	18,genes
R3103	T9970	T9967	dobj	genes,contains
R3104	T9971	T9970	acl	downregulated,genes
R3105	T9972	T9971	prep	at,downregulated
R3106	T9973	T9974	det	the,phase
R3107	T9974	T9972	pobj	phase,at
R3108	T9975	T9974	compound	OA,phase
R3109	T9976	T9967	punct	.,contains
R3110	T9978	T9979	det	The,classification
R3111	T9979	T9982	nsubj	classification,showed
R3112	T9980	T9979	compound	GO,classification
R3113	T9981	T9979	compound	term,classification
R3114	T9983	T9984	det	no,cluster
R3115	T9984	T9982	dobj	cluster,showed
R3116	T9985	T9984	amod	functional,cluster
R3117	T9986	T9987	dep	that,enriched
R3118	T9987	T9984	relcl	enriched,cluster
R3119	T9988	T9987	auxpass	was,enriched
R3120	T9989	T9987	advmod	significantly,enriched
R3121	T9990	T9987	prep	in,enriched
R3122	T9991	T9992	det	these,clusters
R3123	T9992	T9990	pobj	clusters,in
R3124	T9993	T9992	nummod	two,clusters
R3125	T9994	T9992	compound	gene,clusters
R3126	T9995	T9982	punct	.,showed
R3127	T10781	T10782	compound	Candidate,genes
R3128	T10783	T10782	prep	for,genes
R3129	T10784	T10785	det	the,QTL
R3130	T10785	T10783	pobj	QTL,for
R3131	T10786	T10787	amod	small,effect
R3132	T10787	T10785	compound	effect,QTL
R3133	T10788	T10787	punct	-,effect
R3134	T10789	T10785	prep	of,QTL
R3135	T10790	T10789	pobj	CIA,of
R3136	T10792	T10793	aux	To,identify
R3137	T10793	T10794	advcl	identify,compared
R3138	T10794	T10807	ccomp	compared,shared
R3139	T10795	T10796	compound	candidate,genes
R3140	T10796	T10793	dobj	genes,identify
R3141	T10797	T10796	compound	susceptibility,genes
R3142	T10798	T10796	prep	for,genes
R3143	T10799	T10800	det	the,QTL
R3144	T10800	T10798	pobj	QTL,for
R3145	T10801	T10800	nmod	CIA,QTL
R3146	T10802	T10803	amod	small,effect
R3147	T10803	T10800	compound	effect,QTL
R3148	T10804	T10803	punct	-,effect
R3149	T10805	T10794	punct	", ",compared
R3150	T10806	T10794	nsubj	we,compared
R3151	T10808	T10809	det	the,list
R3152	T10809	T10794	dobj	list,compared
R3153	T10810	T10809	prep	of,list
R3154	T10811	T10812	npadvmod	strain,specific
R3155	T10812	T10814	amod	specific,genes
R3156	T10813	T10812	punct	-,specific
R3157	T10814	T10810	pobj	genes,of
R3158	T10815	T10816	advmod	differentially,expressed
R3159	T10816	T10814	amod	expressed,genes
R3160	T10817	T10794	prep	with,compared
R3161	T10818	T10819	det	the,list
R3162	T10819	T10817	pobj	list,with
R3163	T10820	T10819	prep	of,list
R3164	T10821	T10822	npadvmod	disease,specific
R3165	T10822	T10824	amod	specific,genes
R3166	T10823	T10822	punct	-,specific
R3167	T10824	T10820	pobj	genes,of
R3168	T10825	T10826	advmod	differentially,expressed
R3169	T10826	T10824	amod	expressed,genes
R3170	T10827	T10807	punct	;,shared
R3171	T10828	T10829	nummod	117,genes
R3172	T10829	T10807	nsubjpass	genes,shared
R3173	T10830	T10807	auxpass	were,shared
R3174	T10831	T10807	agent	by,shared
R3175	T10832	T10833	det	both,lists
R3176	T10833	T10831	pobj	lists,by
R3177	T10834	T10835	punct	(,file
R3178	T10835	T10807	parataxis	file,shared
R3179	T10836	T10835	amod	Additional,file
R3180	T10837	T10835	nummod	3,file
R3181	T10838	T10835	punct	),file
R3182	T10839	T10807	punct	.,shared
R3183	T10841	T10842	nsubj	Figure,visualises
R3184	T10843	T10841	nummod	3,Figure
R3185	T10844	T10842	dobj	positions,visualises
R3186	T10845	T10844	prep	of,positions
R3187	T10846	T10847	det	the,genes
R3188	T10847	T10845	pobj	genes,of
R3189	T10848	T10847	nummod	117,genes
R3190	T10849	T10847	acl	retrieved,genes
R3191	T10850	T10849	prep	from,retrieved
R3192	T10851	T10850	pobj	Ensembl,from
R3193	T10852	T10853	punct	[,30
R3194	T10853	T10849	parataxis	30,retrieved
R3195	T10854	T10853	punct	],30
R3196	T10855	T10842	prep	in,visualises
R3197	T10856	T10855	pobj	relation,in
R3198	T10857	T10856	prep	to,relation
R3199	T10858	T10859	det	the,QTL
R3201	T10860	T10859	nummod	8,QTL
R3202	T10861	T10862	amod	small,effect
R3203	T10862	T10859	compound	effect,QTL
R3204	T10863	T10862	punct	-,effect
R3205	T10864	T10842	punct	.,visualises
R3206	T10866	T10867	det	The,loci
R3207	T10867	T10869	nsubjpass	loci,located
R3208	T10868	T10867	nummod	eight,loci
R3209	T10870	T10869	auxpass	were,located
R3210	T10871	T10869	prep	on,located
R3211	T10872	T10873	nummod	7,chromosomes
R3212	T10873	T10871	pobj	chromosomes,on
R3213	T10874	T10873	punct	", ",chromosomes
R3214	T10875	T10873	appos	5,chromosomes
R3215	T10876	T10875	punct	", ",5
R3216	T10877	T10875	conj	6,5
R3217	T10878	T10877	punct	", ",6
R3218	T10879	T10877	conj	7,6
R3219	T10880	T10879	punct	", ",7
R3220	T10881	T10879	conj	10,7
R3221	T10882	T10881	punct	", ",10
R3222	T10883	T10881	conj	11,10
R3223	T10884	T10883	punct	", ",11
R3224	T10885	T10883	conj	16,11
R3225	T10886	T10885	cc	and,16
R3226	T10887	T10885	conj	17,16
R3227	T10888	T10869	punct	.,located
R3228	T10890	T10891	mark	Since,are
R3229	T10891	T10900	advcl	are,used
R3230	T10892	T10893	det	the,intervals
R3231	T10893	T10891	nsubj	intervals,are
R3232	T10894	T10893	compound	confidence,intervals
R3233	T10895	T10893	prep	of,intervals
R3234	T10896	T10895	pobj	QTL,of
R3235	T10897	T10893	prep	in,intervals
R3236	T10898	T10899	compound	F2,progeny
R3237	T10899	T10897	pobj	progeny,in
R3238	T10901	T10902	quantmod	around,20
R3239	T10902	T10903	nummod	20,cM
R3240	T10903	T10891	attr	cM,are
R3241	T10904	T10905	punct	[,26
R3242	T10905	T10891	parataxis	26,are
R3243	T10906	T10905	punct	],26
R3244	T10907	T10900	punct	", ",used
R3245	T10908	T10900	nsubj	we,used
R3246	T10909	T10910	nummod	40,Mb
R3247	T10910	T10900	dobj	Mb,used
R3248	T10911	T10900	prep	as,used
R3249	T10912	T10913	det	the,intervals
R3250	T10913	T10911	pobj	intervals,as
R3251	T10914	T10913	compound	confidence,intervals
R3252	T10915	T10913	prep	for,intervals
R3253	T10916	T10917	det	all,loci
R3254	T10917	T10915	pobj	loci,for
R3255	T10918	T10900	punct	.,used
R3256	T10920	T10921	compound	Twenty,one
R3257	T10921	T10923	nummod	one,genes
R3258	T10922	T10921	punct	-,one
R3259	T10923	T10924	nsubjpass	genes,located
R3260	T10925	T10924	auxpass	were,located
R3261	T10926	T10924	prep	in,located
R3262	T10927	T10928	det	the,intervals
R3263	T10928	T10926	pobj	intervals,in
R3264	T10929	T10928	compound	confidence,intervals
R3265	T10930	T10928	prep	of,intervals
R3266	T10931	T10932	quantmod	six,eight
R3267	T10932	T10935	nummod	eight,QTL
R3268	T10933	T10932	quantmod	of,eight
R3269	T10934	T10932	quantmod	the,eight
R3270	T10935	T10930	pobj	QTL,of
R3271	T10936	T10924	punct	.,located
R3272	T10938	T10939	nsubj	We,located
R3273	T10940	T10941	nummod	5,genes
R3274	T10941	T10939	dobj	genes,located
R3275	T10942	T10940	punct	", ",5
R3276	T10943	T10940	conj	4,5
R3277	T10944	T10943	punct	", ",4
R3278	T10945	T10943	conj	2,4
R3279	T10946	T10945	punct	", ",2
R3280	T10947	T10945	conj	1,2
R3281	T10948	T10947	punct	", ",1
R3282	T10949	T10947	conj	3,1
R3283	T10950	T10949	cc	and,3
R3284	T10951	T10949	conj	6,3
R3285	T10952	T10941	amod	potential,genes
R3286	T10953	T10941	compound	candidate,genes
R3287	T10954	T10939	prep	within,located
R3288	T10955	T10956	det	the,intervals
R3289	T10956	T10954	pobj	intervals,within
R3290	T10957	T10956	compound	confidence,intervals
R3291	T10958	T10956	prep	of,intervals
R3292	T10959	T10960	nmod	loci,1
R3293	T10960	T10958	pobj	1,of
R3294	T10961	T10960	punct	", ",1
R3295	T10962	T10960	conj	2,1
R3296	T10963	T10962	punct	", ",2
R3297	T10964	T10962	conj	3,2
R3298	T10965	T10964	punct	", ",3
R3299	T10966	T10964	conj	5,3
R3300	T10967	T10966	punct	", ",5
R3301	T10968	T10966	conj	6,5
R3302	T10969	T10968	cc	and,6
R3303	T10970	T10968	conj	8,6
R3304	T10971	T10939	punct	", ",located
R3305	T10972	T10939	advmod	respectively,located
R3306	T10973	T10939	punct	", ",located
R3307	T10974	T10975	mark	while,identified
R3309	T10976	T10977	det	no,gene
R3310	T10977	T10975	nsubjpass	gene,identified
R3311	T10978	T10977	compound	candidate,gene
R3312	T10979	T10975	auxpass	was,identified
R3313	T10980	T10975	prep	for,identified
R3314	T10981	T10982	nmod	loci,4
R3315	T10982	T10980	pobj	4,for
R3316	T10983	T10982	cc	and,4
R3317	T10984	T10982	conj	7,4
R3318	T10985	T10939	punct	.,located
R3319	T10987	T10988	nsubj	Table,summarises
R3320	T10989	T10987	nummod	3,Table
R3321	T10990	T10991	det	the,genes
R3322	T10991	T10988	dobj	genes,summarises
R3323	T10992	T10991	nummod	21,genes
R3324	T10993	T10991	compound	candidate,genes
R3325	T10994	T10991	acl	identified,genes
R3326	T10995	T10994	prep	in,identified
R3327	T10996	T10997	det	this,study
R3328	T10997	T10995	pobj	study,in
R3329	T10998	T10988	punct	.,summarises
R3330	T11000	T11001	nummod	Two,genes
R3331	T11001	T11002	nsubjpass	genes,upregulated
R3332	T11003	T11001	punct	", ",genes
R3333	T11004	T11001	appos	hspa1a,genes
R3334	T11005	T11004	cc	and,hspa1a
R3335	T11006	T11004	conj	Oas1a,hspa1a
R3336	T11007	T11002	punct	", ",upregulated
R3337	T11008	T11002	auxpass	were,upregulated
R3338	T11009	T11002	prep	at,upregulated
R3339	T11010	T11011	det	the,phase
R3340	T11011	T11009	pobj	phase,at
R3341	T11012	T11011	compound	OA,phase
R3342	T11013	T11011	prep	of,phase
R3343	T11014	T11013	pobj	CIA,of
R3344	T11015	T11002	cc	and,upregulated
R3345	T11016	T11017	nsubjpass	Oas1a,upregulated
R3346	T11017	T11002	conj	upregulated,upregulated
R3347	T11018	T11017	auxpass	was,upregulated
R3348	T11019	T11017	advmod	also,upregulated
R3349	T11020	T11017	prep	at,upregulated
R3350	T11021	T11022	det	the,phase
R3351	T11022	T11020	pobj	phase,at
R3352	T11023	T11022	compound	PI,phase
R3353	T11024	T11017	punct	.,upregulated
R3354	T11026	T11027	prep	Except,downregulated
R3355	T11028	T11026	prep	for,Except
R3356	T11029	T11030	det	these,genes
R3357	T11030	T11028	pobj	genes,for
R3358	T11031	T11030	nummod	two,genes
R3359	T11032	T11027	punct	", ",downregulated
R3360	T11033	T11034	det	all,genes
R3361	T11034	T11027	nsubjpass	genes,downregulated
R3362	T11035	T11034	amod	other,genes
R3363	T11036	T11034	nummod	19,genes
R3364	T11037	T11027	auxpass	were,downregulated
R3365	T11038	T11027	prep	at,downregulated
R3366	T11039	T11040	det	the,phase
R3367	T11040	T11038	pobj	phase,at
R3368	T11041	T11040	amod	chronic,phase
R3369	T11042	T11040	prep	of,phase
R3370	T11043	T11042	pobj	CIA,of
R3371	T11044	T11027	punct	.,downregulated
R3372	T11046	T11047	det	All,genes
R3373	T11047	T11048	nsubj	genes,showed
R3374	T11049	T11047	punct	", ",genes
R3375	T11050	T11047	prep	except,genes
R3376	T11051	T11050	pobj	hspa1a,except
R3377	T11052	T11048	punct	", ",showed
R3378	T11053	T11054	compound	expression,differences
R3379	T11054	T11048	dobj	differences,showed
R3380	T11055	T11054	prep	between,differences
R3381	T11056	T11057	det	the,strains
R3382	T11057	T11055	pobj	strains,between
R3383	T11058	T11057	nummod	two,strains
R3384	T11059	T11048	prep	at,showed
R3385	T11060	T11061	det	the,phase
R3386	T11061	T11059	pobj	phase,at
R3387	T11062	T11061	compound	NC,phase
R3388	T11063	T11048	punct	.,showed
R3389	T11065	T11066	nummod	Five,genes
R3390	T11066	T11067	nsubjpass	genes,expressed
R3391	T11068	T11067	auxpass	were,expressed
R3392	T11069	T11067	advmod	differentially,expressed
R3393	T11070	T11067	prep	at,expressed
R3394	T11071	T11072	det	all,phases
R3395	T11072	T11070	pobj	phases,at
R3396	T11073	T11072	prep	of,phases
R3397	T11074	T11073	pobj	CIA,of
R3398	T11075	T11067	punct	", ",expressed
R3399	T11076	T11067	prep	including,expressed
R3400	T11077	T11078	compound	H2,Q10
R3401	T11078	T11076	pobj	Q10,including
R3402	T11079	T11078	punct	-,Q10
R3403	T11080	T11078	punct	", ",Q10
R3404	T11081	T11078	conj	Mapk14,Q10
R3405	T11082	T11081	punct	", ",Mapk14
R3406	T11083	T11081	conj	Pscd1,Mapk14
R3407	T11084	T11083	punct	", ",Pscd1
R3408	T11085	T11083	conj	Kpnb1,Pscd1
R3409	T11086	T11085	cc	and,Kpnb1
R3410	T11087	T11085	conj	Wdr1,Kpnb1
R3411	T11088	T11067	punct	.,expressed
R3412	T11090	T11091	prep	Among,had
R3413	T11092	T11093	det	these,genes
R3414	T11093	T11090	pobj	genes,Among
R3415	T11094	T11093	nummod	five,genes
R3416	T11095	T11091	punct	", ",had
R3417	T11096	T11097	compound	H2,Q10
R3418	T11097	T11091	nsubj	Q10,had
R3419	T11098	T11097	punct	-,Q10
R3420	T11099	T11100	det	a,expression
R3421	T11100	T11091	dobj	expression,had
R3422	T11101	T11102	advmod	consistently,higher
R3423	T11102	T11100	amod	higher,expression
R3424	T11103	T11091	prep	in,had
R3425	T11104	T11105	det	the,DBA
R3426	T11105	T11103	pobj	DBA,in
R3427	T11106	T11105	punct	/,DBA
R3428	T11107	T11105	nummod	1,DBA
R3429	T11108	T11091	prep	than,had
R3430	T11109	T11110	det	the,strain
R3431	T11110	T11108	pobj	strain,than
R3432	T11111	T11112	compound	FVB,N
R3433	T11112	T11110	compound	N,strain
R3434	T11113	T11112	punct	/,N
R3435	T11114	T11091	prep	in,had
R3436	T11115	T11116	det	all,phases
R3437	T11116	T11114	pobj	phases,in
R3438	T11117	T11116	compound	CIA,phases
R3439	T11118	T11091	punct	", ",had
R3440	T11119	T11120	mark	while,had
R3442	T11121	T11122	det	the,genes
R3443	T11122	T11120	nsubj	genes,had
R3444	T11123	T11122	amod	other,genes
R3445	T11124	T11122	nummod	four,genes
R3446	T11125	T11126	det	a,expression
R3447	T11126	T11120	dobj	expression,had
R3448	T11127	T11126	amod	higher,expression
R3449	T11128	T11120	prep	in,had
R3450	T11129	T11130	det	the,strain
R3451	T11130	T11128	pobj	strain,in
R3452	T11131	T11130	nmod	DBA,strain
R3453	T11132	T11131	punct	/,DBA
R3454	T11133	T11131	nummod	1,DBA
R3455	T11134	T11120	prep	at,had
R3456	T11135	T11136	det	the,stages
R3457	T11136	T11134	pobj	stages,at
R3458	T11137	T11136	amod	early,stages
R3459	T11138	T11120	punct	", ",had
R3460	T11139	T11120	prep	including,had
R3461	T11140	T11139	pobj	NC,including
R3462	T11141	T11140	punct	", ",NC
R3463	T11142	T11140	conj	PI,NC
R3464	T11143	T11142	cc	and,PI
R3465	T11144	T11142	conj	OA,PI
R3466	T11145	T11120	punct	", ",had
R3467	T11146	T11120	cc	but,had
R3468	T11147	T11148	det	a,expression
R3469	T11148	T11120	conj	expression,had
R3470	T11149	T11148	amod	lower,expression
R3471	T11150	T11148	prep	at,expression
R3472	T11151	T11152	det	the,phase
R3473	T11152	T11150	pobj	phase,at
R3474	T11153	T11152	amod	chronic,phase
R3475	T11154	T11091	punct	.,had
R3476	T11156	T11157	compound	GO,analysis
R3477	T11157	T11160	nsubj	analysis,revealed
R3478	T11158	T11157	compound	term,analysis
R3479	T11159	T11157	compound	classification,analysis
R3480	T11161	T11162	mark	that,enriched
R3481	T11162	T11160	ccomp	enriched,revealed
R3482	T11163	T11164	det	the,cluster
R3483	T11164	T11162	nsubjpass	cluster,enriched
R3484	T11165	T11164	amod	functional,cluster
R3485	T11166	T11164	prep	of,cluster
R3486	T11167	T11168	compound	protein,cascade
R3487	T11168	T11166	pobj	cascade,of
R3488	T11169	T11168	compound	kinase,cascade
R3489	T11170	T11162	auxpass	was,enriched
R3490	T11171	T11162	advmod	significantly,enriched
R3491	T11172	T11162	prep	in,enriched
R3492	T11173	T11174	det	the,genes
R3493	T11174	T11172	pobj	genes,in
R3494	T11175	T11174	nummod	21,genes
R3495	T11176	T11174	compound	candidate,genes
R3496	T11177	T11160	punct	.,revealed
R3497	T11179	T11180	det	This,cluster
R3498	T11180	T11182	nsubj	cluster,contained
R3499	T11181	T11180	amod	functional,cluster
R3500	T11183	T11184	nummod	four,genes
R3501	T11184	T11182	dobj	genes,contained
R3502	T11185	T11184	punct	", ",genes
R3503	T11186	T11184	prep	including,genes
R3504	T11187	T11186	pobj	Mapk14,including
R3505	T11188	T11187	punct	", ",Mapk14
R3506	T11189	T11187	conj	Mapk8ip3,Mapk14
R3507	T11190	T11189	punct	", ",Mapk8ip3
R3508	T11191	T11189	conj	Stat5a,Mapk8ip3
R3509	T11192	T11191	cc	and,Stat5a
R3510	T11193	T11191	conj	Gna12,Stat5a
R3511	T11194	T11182	punct	.,contained
R2448	T8324	T8322	dobj	profiles,detected
R2520	T8402	T8405	nsubj	CV,indicated
R2544	T8428	T8424	pobj	genes,for
R2696	T8592	T8586	nsubjpass	genes,expressed
R3200	T10859	T10857	pobj	QTL,to
R3308	T10975	T10939	advcl	identified,located
R3441	T11120	T11091	advcl	had,had
R1917	T7178	T7176	ccomp	be,indicating
R1927	T7188	T7182	relcl	were,QTL
R1936	T7197	T7195	dobj	value,reach
R1956	T7219	T7217	dobj	value,using
R1962	T7225	T7219	parataxis	0.05,value
R2010	T7275	T7234	nsubjpass	QTL,masked
R2038	T7305	T7303	dobj	progeny,containing
R2081	T7350	T7331	advcl	varying,linked
R2317	T7604	T7607	nmod	C,progeny
R2332	T7620	T7623	nsubjpass	regions,reported
R2436	T7727	T7644	parataxis	4,are

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7051	1782-1789	SO_EXT:0001026	denotes	genomic
T7052	1831-1839	_FRAGMENT	denotes	syntenic
T7053	1848-1855	SO_EXT:0005858	denotes	regions
T7054	1840-1847	SO_EXT:0001026	denotes	genomic
T7055	1863-1868	NCBITaxon:9606	denotes	human
T7056	1869-1875	SO_EXT:0001026	denotes	genome
T7057	1937-1940	SO_EXT:0000771	denotes	QTL
T7058	1967-1970	SO_EXT:0000771	denotes	QTL
T7059	1978-1983	NCBITaxon:10088	denotes	mouse
T7060	1984-1990	SO_EXT:0001026	denotes	genome
T7026	101-107	SO_EXT:0001026	denotes	genome
T7027	127-130	SO_EXT:0000771	denotes	QTL
T7028	131-142	GO:0065007	denotes	controlling
T7029	243-246	SO_EXT:0000771	denotes	QTL
T7030	459-462	SO_EXT:0000771	denotes	QTL
T7031	604-607	SO_EXT:0000771	denotes	QTL
T7032	727-731	SO_EXT:0000704	denotes	gene
T7033	741-764	PR_EXT:000004904	denotes	complement component C5
T7034	766-768	PR_EXT:000004904	denotes	Hc
T7035	850-852	PR_EXT:000004904	denotes	C5
T7036	890-893	SO_EXT:0000771	denotes	QTL
T7037	952-954	PR_EXT:000004904	denotes	C5
T7038	1058-1060	PR_EXT:000004904	denotes	C5
T7039	1060-1061	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7040	1062-1063	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7041	1093-1095	PR_EXT:000004904	denotes	C5
T7042	1095-1096	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7043	1097-1098	SO_EXT:sequence_nullness_or_absence	denotes	-
T7044	1117-1124	SO_EXT:0001026	denotes	genomic
T7045	1274-1277	SO_EXT:0000771	denotes	QTL
T7046	1294-1305	GO_SO_EXT:chromosome	denotes	chromosomes
T7047	1443-1449	SO_EXT:0001023	denotes	allele
T7048	1493-1499	SO_EXT:0001023	denotes	allele
T7049	1690-1693	SO_EXT:0000771	denotes	QTL
T7050	1738-1741	SO_EXT:0000771	denotes	QTL
T7061	2064-2071	GO:0065007	denotes	control
T7062	2144-2154	GO_SO_EXT:chromosome	denotes	chromosome
T7063	2270-2278	GO:0065007	denotes	controls
T7064	2297-2309	CHEBI:37396	denotes	proteoglycan
T7065	2395-2403	_FRAGMENT	denotes	syntenic
T7066	2412-2419	SO_EXT:0005858	denotes	regions
T7067	2404-2411	SO_EXT:0001026	denotes	genomic
T7068	2441-2444	SO_EXT:0000771	denotes	QTL
T7069	2452-2457	NCBITaxon:9606	denotes	human
T7070	2458-2464	SO_EXT:0001026	denotes	genome
T7071	2514-2521	SO_EXT:0001026	denotes	genomic
T7072	2553-2563	GO_SO_EXT:chromosome	denotes	chromosome
T7073	2619-2629	GO_SO_EXT:chromosome	denotes	chromosome
T7074	2690-2700	GO_SO_EXT:chromosome	denotes	chromosome
T7075	2754-2764	GO_SO_EXT:chromosome	denotes	chromosome
T7076	2814-2824	GO_SO_EXT:chromosome	denotes	chromosome
T7077	2814-2826	GO_SO_EXT:chromosome	denotes	chromosome 3
T8286	2895-2904	GO:0010467	denotes	expressed
T8287	2905-2910	SO_EXT:0000704	denotes	genes
T8288	2927-2931	SO_EXT:0000704	denotes	gene
T8289	2927-2942	GO:0010467	denotes	gene expression
T8290	2964-2968	NCBITaxon:10088	denotes	mice
T8291	3153-3157	SO_EXT:0000704	denotes	gene
T8292	3201-3206	CHEBI_SO_EXT:molecular_probe	denotes	probe
T8293	3444-3453	GO:0010467	denotes	expressed
T8294	3454-3459	SO_EXT:0000704	denotes	genes
T8295	3489-3493	SO_EXT:0000704	denotes	gene
T8296	3489-3504	GO:0010467	denotes	gene expression
T8297	3611-3615	NCBITaxon:10088	denotes	mice
T8298	3642-3647	SO_EXT:0000704	denotes	genes
T8299	3668-3677	GO:0010467	denotes	expressed
T8300	3793-3798	SO_EXT:0000704	denotes	genes
T8301	3819-3828	GO:0010467	denotes	expressed
T8302	3842-3846	NCBITaxon:10088	denotes	mice
T8303	3888-3897	GO:0010467	denotes	expressed
T8304	3898-3903	SO_EXT:0000704	denotes	genes
T8305	4030-4039	GO:0010467	denotes	expressed
T8306	4040-4045	SO_EXT:0000704	denotes	genes
T8307	4093-4098	SO_EXT:0000704	denotes	genes
T8308	4118-4123	SO_EXT:0000704	denotes	genes
T8309	4172-4177	SO_EXT:0000704	denotes	genes
T8310	4211-4221	GO:0010467	denotes	expression
T8311	4278-4283	SO_EXT:0000704	denotes	genes
T8312	4303-4308	SO_EXT:0000704	denotes	genes
T8313	4345-4354	GO:0010467	denotes	expressed
T9495	5042-5047	SO_EXT:0000704	denotes	genes
T9496	5058-5062	SO_EXT:0000704	denotes	gene
T9497	5082-5091	GO:0010467	denotes	expressed
T9498	5133-5137	SO_EXT:0000704	denotes	gene
T9499	5172-5181	GO:0010467	denotes	expressed
T9500	5182-5187	SO_EXT:0000704	denotes	genes
T9480	4455-4464	GO:0010467	denotes	expressed
T9481	4465-4470	SO_EXT:0000704	denotes	genes
T9482	4519-4528	GO:0010467	denotes	expressed
T9483	4529-4534	SO_EXT:0000704	denotes	genes
T9484	4559-4564	SO_EXT:0000704	denotes	genes
T9485	4590-4599	GO:0010467	denotes	expressed
T9486	4603-4606	UBERON:0000029	denotes	LNs
T9487	4758-4763	SO_EXT:0000704	denotes	genes
T9488	4784-4793	GO:0010467	denotes	expressed
T9489	4814-4825	GO_EXT:positive_regulation	denotes	upregulated
T9490	4893-4898	SO_EXT:0000704	denotes	genes
T9491	4919-4928	GO:0010467	denotes	expressed
T9492	4986-4995	GO:0010467	denotes	expressed
T9493	4996-5001	SO_EXT:0000704	denotes	genes
T9494	5028-5041	GO_EXT:negative_regulation	denotes	downregulated
T9501	5320-5329	GO:0010467	denotes	expressed
T9502	5330-5335	SO_EXT:0000704	denotes	genes
T9503	5356-5365	GO:0065007	denotes	regulated
T9504	5386-5390	NCBITaxon:10088	denotes	mice
T9505	5440-5444	SO_EXT:0000704	denotes	gene
T9506	5440-5455	GO:0010467	denotes	gene expression
T9507	5533-5538	SO_EXT:0000704	denotes	genes
T9508	5544-5548	SO_EXT:0000704	denotes	gene
T9509	5626-5630	SO_EXT:0000704	denotes	gene
T9510	5626-5641	GO:0010467	denotes	gene expression
T9511	5684-5689	SO_EXT:0000704	denotes	genes
T9512	5704-5709	SO_EXT:0000704	denotes	genes
T9513	5720-5731	GO_EXT:positive_regulation	denotes	upregulated
T9514	5760-5770	GO:0010467	denotes	expression
T9515	5780-5785	SO_EXT:0000704	denotes	genes
T9516	5907-5913	UBERON:0002405	denotes	immune
T9517	5907-5922	GO:0006955	denotes	immune response
T9518	5947-5952	SO_EXT:0000704	denotes	genes
T9519	5959-5969	GO:0010467	denotes	expression
T9520	5984-5995	GO_EXT:positive_regulation	denotes	upregulated
T9521	6050-6055	SO_EXT:0000704	denotes	genes
T9522	6082-6088	UBERON:0002405	denotes	immune
T9523	6082-6097	GO:0006955	denotes	immune response
T9524	6099-6117	GO:0031090	denotes	organelle membrane
T9525	6122-6142	GO:0005576	denotes	extracellular region
T9526	6122-6135	_FRAGMENT	denotes	extracellular
T9527	6147-6152	GO:0005615	denotes	space
T9528	6127-6135	CL_GO_EXT:cell	denotes	cellular
T9529	6178-6183	SO_EXT:0000704	denotes	genes
T9530	6199-6210	GO_EXT:positive_regulation	denotes	upregulated
T9531	6234-6239	SO_EXT:0000704	denotes	genes
T9532	6259-6281	GO:0005911	denotes	intercellular junction
T9533	6264-6272	CL_GO_EXT:cell	denotes	cellular
T9534	6305-6310	SO_EXT:0000704	denotes	genes
T9535	6359-6364	SO_EXT:0000704	denotes	genes
T9536	6378-6391	GO_EXT:negative_regulation	denotes	downregultaed
T9537	6420-6425	SO_EXT:0000704	denotes	genes
T9538	6454-6464	CL:0000542	denotes	lymphocyte
T9539	6454-6478	GO:0046651	denotes	lymphocyte proliferation
T9540	6480-6486	CL:0000084	denotes	T cell
T9541	6480-6497	GO:0042110	denotes	T cell activation
T9542	6482-6486	CL_GO_EXT:cell	denotes	cell
T9543	6499-6506	CHEBI_PR_EXT:protein	denotes	protein
T9544	6507-6514	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9545	6530-6535	PR_EXT:Notch	denotes	notch
T9546	6530-6550	GO:0007219	denotes	notch signal pathway
T9547	6577-6582	SO_EXT:0000704	denotes	genes
T9548	6583-6596	GO_EXT:negative_regulation	denotes	downregulated
T9549	6637-6642	SO_EXT:0000704	denotes	genes
T9550	6643-6656	GO_EXT:negative_regulation	denotes	downregulated
T9551	6775-6779	SO_EXT:0000704	denotes	gene
T10760	8079-8084	SO_EXT:0000704	denotes	genes
T10761	8105-8114	GO:0010467	denotes	expressed
T10762	8147-8153	PR_EXT:000008409	denotes	H2-Q10
T10763	8155-8161	PR_EXT:000003107	denotes	Mapk14
T10764	8163-8168	PR_EXT:000006153	denotes	Pscd1
T10765	8170-8175	PR_EXT:000009439	denotes	Kpnb1
T10730	6801-6806	SO_EXT:0000704	denotes	genes
T10731	6828-6831	SO_EXT:0000771	denotes	QTL
T10732	6907-6910	SO_EXT:0000771	denotes	QTL
T10733	6967-6976	GO:0010467	denotes	expressed
T10734	6977-6982	SO_EXT:0000704	denotes	genes
T10735	7032-7041	GO:0010467	denotes	expressed
T10736	7042-7047	SO_EXT:0000704	denotes	genes
T10737	7053-7058	SO_EXT:0000704	denotes	genes
T10738	7147-7152	SO_EXT:0000704	denotes	genes
T10739	7215-7218	SO_EXT:0000771	denotes	QTL
T10740	7253-7264	GO_SO_EXT:chromosome	denotes	chromosomes
T10741	7328-7331	SO_EXT:0000771	denotes	QTL
T10742	7381-7382	CHEBI_SO_EXT:base	denotes	b
T10743	7436-7441	SO_EXT:0000704	denotes	genes
T10744	7503-7506	SO_EXT:0000771	denotes	QTL
T10745	7559-7564	SO_EXT:0000704	denotes	genes
T10746	7659-7663	SO_EXT:0000704	denotes	gene
T10747	7733-7738	SO_EXT:0000704	denotes	genes
T10748	7769-7774	SO_EXT:0000704	denotes	genes
T10749	7776-7782	PR_EXT:000008871	denotes	hspa1a
T10750	7787-7792	PR_EXT:000012101	denotes	Oas1a
T10751	7799-7810	GO_EXT:positive_regulation	denotes	upregulated
T10752	7838-7843	PR_EXT:000012101	denotes	Oas1a
T10753	7853-7864	GO_EXT:positive_regulation	denotes	upregulated
T10754	7903-7908	SO_EXT:0000704	denotes	genes
T10755	7923-7928	SO_EXT:0000704	denotes	genes
T10756	7934-7947	GO_EXT:negative_regulation	denotes	downregulated
T10757	7981-7986	SO_EXT:0000704	denotes	genes
T10758	7995-8001	PR_EXT:000008871	denotes	hspa1a
T10759	8010-8020	GO:0010467	denotes	expression
T10766	8180-8184	PR_EXT:000017387	denotes	Wdr1
T10767	8203-8208	SO_EXT:0000704	denotes	genes
T10768	8210-8216	PR_EXT:000008409	denotes	H2-Q10
T10769	8243-8253	GO:0010467	denotes	expression
T10770	8329-8334	SO_EXT:0000704	denotes	genes
T10771	8348-8358	GO:0010467	denotes	expression
T10772	8437-8447	GO:0010467	denotes	expression
T10773	8542-8549	CHEBI_PR_EXT:protein	denotes	protein
T10774	8542-8556	GO_EXT:0004672	denotes	protein kinase
T10775	8612-8617	SO_EXT:0000704	denotes	genes
T10776	8658-8663	SO_EXT:0000704	denotes	genes
T10777	8675-8681	PR_EXT:000003107	denotes	Mapk14
T10778	8683-8691	PR_EXT:000010162	denotes	Mapk8ip3
T10779	8693-8699	PR_EXT:000002091	denotes	Stat5a
T10780	8704-8709	PR_EXT:000008081	denotes	Gna12
T7025	22-25	SO_EXT:0000771	denotes	QTL
R1822	T7053	T7052	_lexicallyChainedTo	regions,syntenic
R1823	T7066	T7065	_lexicallyChainedTo	regions,syntenic
R2723	T9527	T9526	_lexicallyChainedTo	space,extracellular

2_test

Id	Subject	Object	Predicate	Lexical cue
17244351-15529344-4361130	337-339	15529344	denotes	10
17244351-15529344-4361131	864-866	15529344	denotes	10
17244351-10754334-4361132	867-869	10754334	denotes	25
17244351-2563713-4361133	1522-1524	2563713	denotes	26
17244351-12594249-4361134	2120-2122	12594249	denotes	27
17244351-10453039-4361135	2230-2232	10453039	denotes	28
17244351-11046062-4361136	2386-2388	11046062	denotes	29
17244351-9724775-4361137	2857-2858	9724775	denotes	2
17244351-12687532-4361138	2859-2860	12687532	denotes	4
17244351-2563713-4361139	7364-7366	2563713	denotes	26

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T6984	22-25	SO:0000771	denotes	QTL
T6985	101-107	SO:0001026	denotes	genome
T6986	127-130	SO:0000771	denotes	QTL
T6987	131-142	GO:0065007	denotes	controlling
T6988	243-246	SO:0000771	denotes	QTL
T6989	459-462	SO:0000771	denotes	QTL
T6990	604-607	SO:0000771	denotes	QTL
T6991	727-731	SO:0000704	denotes	gene
T6992	741-764	PR:000004904	denotes	complement component C5
T6993	766-768	PR:000004904	denotes	Hc
T6994	850-852	PR:000004904	denotes	C5
T6995	890-893	SO:0000771	denotes	QTL
T6996	952-954	PR:000004904	denotes	C5
T6997	1058-1060	PR:000004904	denotes	C5
T6998	1093-1095	PR:000004904	denotes	C5
T6999	1117-1124	SO:0001026	denotes	genomic
T7000	1274-1277	SO:0000771	denotes	QTL
T7001	1443-1449	SO:0001023	denotes	allele
T7002	1493-1499	SO:0001023	denotes	allele
T7003	1690-1693	SO:0000771	denotes	QTL
T7004	1738-1741	SO:0000771	denotes	QTL
T7005	1782-1789	SO:0001026	denotes	genomic
T7006	1831-1839	_FRAGMENT	denotes	syntenic
T7007	1848-1855	SO:0005858	denotes	regions
T7008	1840-1847	SO:0001026	denotes	genomic
T7009	1863-1868	NCBITaxon:9606	denotes	human
T7010	1869-1875	SO:0001026	denotes	genome
T7011	1937-1940	SO:0000771	denotes	QTL
T7012	1967-1970	SO:0000771	denotes	QTL
T7013	1978-1983	NCBITaxon:10088	denotes	mouse
T7014	1984-1990	SO:0001026	denotes	genome
T7015	2064-2071	GO:0065007	denotes	control
T7016	2270-2278	GO:0065007	denotes	controls
T7017	2297-2309	CHEBI:37396	denotes	proteoglycan
T7018	2395-2403	_FRAGMENT	denotes	syntenic
T7019	2412-2419	SO:0005858	denotes	regions
T7020	2404-2411	SO:0001026	denotes	genomic
T7021	2441-2444	SO:0000771	denotes	QTL
T7022	2452-2457	NCBITaxon:9606	denotes	human
T7023	2458-2464	SO:0001026	denotes	genome
T7024	2514-2521	SO:0001026	denotes	genomic
T8259	2895-2904	GO:0010467	denotes	expressed
T8260	2905-2910	SO:0000704	denotes	genes
T8261	2927-2931	SO:0000704	denotes	gene
T8262	2927-2942	GO:0010467	denotes	gene expression
T8263	2964-2968	NCBITaxon:10088	denotes	mice
T8264	3153-3157	SO:0000704	denotes	gene
T8265	3444-3453	GO:0010467	denotes	expressed
T8266	3454-3459	SO:0000704	denotes	genes
T8267	3489-3493	SO:0000704	denotes	gene
T8268	3489-3504	GO:0010467	denotes	gene expression
T8269	3611-3615	NCBITaxon:10088	denotes	mice
T8270	3642-3647	SO:0000704	denotes	genes
T8271	3668-3677	GO:0010467	denotes	expressed
T8272	3793-3798	SO:0000704	denotes	genes
T8273	3819-3828	GO:0010467	denotes	expressed
T8274	3842-3846	NCBITaxon:10088	denotes	mice
T8275	3888-3897	GO:0010467	denotes	expressed
T8276	3898-3903	SO:0000704	denotes	genes
T8277	4030-4039	GO:0010467	denotes	expressed
T8278	4040-4045	SO:0000704	denotes	genes
T8279	4093-4098	SO:0000704	denotes	genes
T8280	4118-4123	SO:0000704	denotes	genes
T8281	4172-4177	SO:0000704	denotes	genes
T8282	4211-4221	GO:0010467	denotes	expression
T8283	4278-4283	SO:0000704	denotes	genes
T8284	4303-4308	SO:0000704	denotes	genes
T8285	4345-4354	GO:0010467	denotes	expressed
T9422	4455-4464	GO:0010467	denotes	expressed
T9423	4465-4470	SO:0000704	denotes	genes
T9424	4519-4528	GO:0010467	denotes	expressed
T9425	4529-4534	SO:0000704	denotes	genes
T9426	4559-4564	SO:0000704	denotes	genes
T9427	4590-4599	GO:0010467	denotes	expressed
T9428	4603-4606	UBERON:0000029	denotes	LNs
T9429	4758-4763	SO:0000704	denotes	genes
T9430	4784-4793	GO:0010467	denotes	expressed
T9431	4893-4898	SO:0000704	denotes	genes
T9432	4919-4928	GO:0010467	denotes	expressed
T9433	4986-4995	GO:0010467	denotes	expressed
T9434	4996-5001	SO:0000704	denotes	genes
T9435	5042-5047	SO:0000704	denotes	genes
T9436	5058-5062	SO:0000704	denotes	gene
T9437	5082-5091	GO:0010467	denotes	expressed
T9438	5133-5137	SO:0000704	denotes	gene
T9439	5172-5181	GO:0010467	denotes	expressed
T9440	5182-5187	SO:0000704	denotes	genes
T9441	5320-5329	GO:0010467	denotes	expressed
T9442	5330-5335	SO:0000704	denotes	genes
T9443	5356-5365	GO:0065007	denotes	regulated
T9444	5386-5390	NCBITaxon:10088	denotes	mice
T9445	5440-5444	SO:0000704	denotes	gene
T9446	5440-5455	GO:0010467	denotes	gene expression
T9447	5533-5538	SO:0000704	denotes	genes
T9448	5544-5548	SO:0000704	denotes	gene
T9449	5626-5630	SO:0000704	denotes	gene
T9450	5626-5641	GO:0010467	denotes	gene expression
T9451	5684-5689	SO:0000704	denotes	genes
T9452	5704-5709	SO:0000704	denotes	genes
T9453	5760-5770	GO:0010467	denotes	expression
T9454	5780-5785	SO:0000704	denotes	genes
T9455	5907-5913	UBERON:0002405	denotes	immune
T9456	5907-5922	GO:0006955	denotes	immune response
T9457	5947-5952	SO:0000704	denotes	genes
T9458	5959-5969	GO:0010467	denotes	expression
T9459	6050-6055	SO:0000704	denotes	genes
T9460	6082-6088	UBERON:0002405	denotes	immune
T9461	6082-6097	GO:0006955	denotes	immune response
T9462	6099-6117	GO:0031090	denotes	organelle membrane
T9463	6122-6142	GO:0005576	denotes	extracellular region
T9464	6122-6135	_FRAGMENT	denotes	extracellular
T9465	6147-6152	GO:0005615	denotes	space
T9466	6178-6183	SO:0000704	denotes	genes
T9467	6234-6239	SO:0000704	denotes	genes
T9468	6259-6281	GO:0005911	denotes	intercellular junction
T9469	6305-6310	SO:0000704	denotes	genes
T9470	6359-6364	SO:0000704	denotes	genes
T9471	6420-6425	SO:0000704	denotes	genes
T9472	6454-6464	CL:0000542	denotes	lymphocyte
T9473	6454-6478	GO:0046651	denotes	lymphocyte proliferation
T9474	6480-6486	CL:0000084	denotes	T cell
T9475	6480-6497	GO:0042110	denotes	T cell activation
T9476	6530-6550	GO:0007219	denotes	notch signal pathway
T9477	6577-6582	SO:0000704	denotes	genes
T9478	6637-6642	SO:0000704	denotes	genes
T9479	6775-6779	SO:0000704	denotes	gene
T10686	6801-6806	SO:0000704	denotes	genes
T10687	6828-6831	SO:0000771	denotes	QTL
T10688	6907-6910	SO:0000771	denotes	QTL
T10689	6967-6976	GO:0010467	denotes	expressed
T10690	6977-6982	SO:0000704	denotes	genes
T10691	7032-7041	GO:0010467	denotes	expressed
T10692	7042-7047	SO:0000704	denotes	genes
T10693	7053-7058	SO:0000704	denotes	genes
T10694	7147-7152	SO:0000704	denotes	genes
T10695	7215-7218	SO:0000771	denotes	QTL
T10696	7328-7331	SO:0000771	denotes	QTL
T10697	7436-7441	SO:0000704	denotes	genes
T10698	7503-7506	SO:0000771	denotes	QTL
T10699	7559-7564	SO:0000704	denotes	genes
T10700	7659-7663	SO:0000704	denotes	gene
T10701	7733-7738	SO:0000704	denotes	genes
T10702	7769-7774	SO:0000704	denotes	genes
T10703	7776-7782	PR:000008871	denotes	hspa1a
T10704	7787-7792	PR:000012101	denotes	Oas1a
T10705	7838-7843	PR:000012101	denotes	Oas1a
T10706	7903-7908	SO:0000704	denotes	genes
T10707	7923-7928	SO:0000704	denotes	genes
T10708	7981-7986	SO:0000704	denotes	genes
T10709	7995-8001	PR:000008871	denotes	hspa1a
T10710	8010-8020	GO:0010467	denotes	expression
T10711	8079-8084	SO:0000704	denotes	genes
T10712	8105-8114	GO:0010467	denotes	expressed
T10713	8147-8153	PR:000008409	denotes	H2-Q10
T10714	8155-8161	PR:000003107	denotes	Mapk14
T10715	8163-8168	PR:000006153	denotes	Pscd1
T10716	8170-8175	PR:000009439	denotes	Kpnb1
T10717	8180-8184	PR:000017387	denotes	Wdr1
T10718	8203-8208	SO:0000704	denotes	genes
T10719	8210-8216	PR:000008409	denotes	H2-Q10
T10720	8243-8253	GO:0010467	denotes	expression
T10721	8329-8334	SO:0000704	denotes	genes
T10722	8348-8358	GO:0010467	denotes	expression
T10723	8437-8447	GO:0010467	denotes	expression
T10724	8612-8617	SO:0000704	denotes	genes
T10725	8658-8663	SO:0000704	denotes	genes
T10726	8675-8681	PR:000003107	denotes	Mapk14
T10727	8683-8691	PR:000010162	denotes	Mapk8ip3
T10728	8693-8699	PR:000002091	denotes	Stat5a
T10729	8704-8709	PR:000008081	denotes	Gna12
R1820	T7007	T7006	_lexicallyChainedTo	regions,syntenic
R1821	T7019	T7018	_lexicallyChainedTo	regions,syntenic
R2722	T9465	T9464	_lexicallyChainedTo	space,extracellular

PMC:1860061 / 10336-19046 JSONTXT

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craft-sa-dev

craft-ca-core-ex-dev

2_test

craft-ca-core-dev

PMC:1860061 / 10336-19046 JSON TXT