| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1014 |
0-7 |
NNS |
denotes |
Results |
| T1015 |
7-141 |
sentence |
denotes |
Each mutation deleted >80% of the coding sequence, including the critical PHD domain, and almost certainly resulted in null function. |
| T1016 |
8-12 |
DT |
denotes |
Each |
| T1017 |
13-21 |
NN |
denotes |
mutation |
| T1018 |
115-123 |
VBD |
denotes |
resulted |
| T1019 |
22-29 |
VBD |
denotes |
deleted |
| T1020 |
30-31 |
SYM |
denotes |
> |
| T1021 |
31-33 |
CD |
denotes |
80 |
| T1022 |
33-34 |
NN |
denotes |
% |
| T1023 |
35-37 |
IN |
denotes |
of |
| T1024 |
38-41 |
DT |
denotes |
the |
| T1025 |
49-57 |
NN |
denotes |
sequence |
| T1026 |
42-48 |
NN |
denotes |
coding |
| T1027 |
57-59 |
, |
denotes |
, |
| T1028 |
59-68 |
VBG |
denotes |
including |
| T1029 |
69-72 |
DT |
denotes |
the |
| T1030 |
86-92 |
NN |
denotes |
domain |
| T1031 |
73-81 |
JJ |
denotes |
critical |
| T1032 |
82-85 |
NN |
denotes |
PHD |
| T1033 |
92-94 |
, |
denotes |
, |
| T1034 |
94-97 |
CC |
denotes |
and |
| T1035 |
98-104 |
RB |
denotes |
almost |
| T1036 |
105-114 |
RB |
denotes |
certainly |
| T1037 |
124-126 |
IN |
denotes |
in |
| T1038 |
127-131 |
JJ |
denotes |
null |
| T1039 |
132-140 |
NN |
denotes |
function |
| T1040 |
140-141 |
. |
denotes |
. |
| T1041 |
141-352 |
sentence |
denotes |
Pygo2 homozygous mutants, with rare exception, died shortly after birth, with a phenotype including lens agenesis, growth retardation, altered kidney development, and in some cases exencephaly and cleft palate. |
| T1042 |
142-147 |
NN |
denotes |
Pygo2 |
| T1043 |
148-158 |
JJ |
denotes |
homozygous |
| T1044 |
159-166 |
NNS |
denotes |
mutants |
| T1045 |
189-193 |
VBD |
denotes |
died |
| T1046 |
166-168 |
, |
denotes |
, |
| T1047 |
168-172 |
IN |
denotes |
with |
| T1048 |
173-177 |
JJ |
denotes |
rare |
| T1049 |
178-187 |
NN |
denotes |
exception |
| T1050 |
187-189 |
, |
denotes |
, |
| T1051 |
194-201 |
RB |
denotes |
shortly |
| T1052 |
202-207 |
IN |
denotes |
after |
| T1053 |
208-213 |
NN |
denotes |
birth |
| T1054 |
213-215 |
, |
denotes |
, |
| T1055 |
215-219 |
IN |
denotes |
with |
| T1056 |
220-221 |
DT |
denotes |
a |
| T1057 |
222-231 |
NN |
denotes |
phenotype |
| T1058 |
232-241 |
VBG |
denotes |
including |
| T1059 |
242-246 |
NN |
denotes |
lens |
| T1060 |
247-255 |
NN |
denotes |
agenesis |
| T1061 |
255-257 |
, |
denotes |
, |
| T1062 |
257-263 |
NN |
denotes |
growth |
| T1063 |
264-275 |
NN |
denotes |
retardation |
| T1064 |
275-277 |
, |
denotes |
, |
| T1065 |
277-284 |
VBN |
denotes |
altered |
| T1066 |
292-303 |
NN |
denotes |
development |
| T1067 |
285-291 |
NN |
denotes |
kidney |
| T1068 |
303-305 |
, |
denotes |
, |
| T1069 |
305-308 |
CC |
denotes |
and |
| T1070 |
309-311 |
IN |
denotes |
in |
| T1071 |
323-334 |
NN |
denotes |
exencephaly |
| T1072 |
312-316 |
DT |
denotes |
some |
| T1073 |
317-322 |
NNS |
denotes |
cases |
| T1074 |
335-338 |
CC |
denotes |
and |
| T1075 |
339-344 |
VBN |
denotes |
cleft |
| T1076 |
345-351 |
NN |
denotes |
palate |
| T1077 |
351-352 |
. |
denotes |
. |
| T1078 |
352-454 |
sentence |
denotes |
Pygo1 homozygous mutants, however, were viable and fertile, with no detectable developmental defects. |
| T1079 |
353-358 |
NN |
denotes |
Pygo1 |
| T1080 |
359-369 |
JJ |
denotes |
homozygous |
| T1081 |
370-377 |
NNS |
denotes |
mutants |
| T1082 |
388-392 |
VBD |
denotes |
were |
| T1083 |
377-379 |
, |
denotes |
, |
| T1084 |
379-386 |
RB |
denotes |
however |
| T1085 |
386-388 |
, |
denotes |
, |
| T1086 |
393-399 |
JJ |
denotes |
viable |
| T1087 |
400-403 |
CC |
denotes |
and |
| T1088 |
404-411 |
JJ |
denotes |
fertile |
| T1089 |
411-413 |
, |
denotes |
, |
| T1090 |
413-417 |
IN |
denotes |
with |
| T1091 |
418-420 |
DT |
denotes |
no |
| T1092 |
446-453 |
NNS |
denotes |
defects |
| T1093 |
421-431 |
JJ |
denotes |
detectable |
| T1094 |
432-445 |
JJ |
denotes |
developmental |
| T1095 |
453-454 |
. |
denotes |
. |
| T1096 |
454-542 |
sentence |
denotes |
Double Pygo1/Pygo2 homozygous mutants showed no apparent synergy in phenotype severity. |
| T1097 |
455-461 |
JJ |
denotes |
Double |
| T1098 |
468-473 |
NN |
denotes |
Pygo2 |
| T1099 |
462-467 |
NN |
denotes |
Pygo1 |
| T1100 |
467-468 |
HYPH |
denotes |
/ |
| T1101 |
474-484 |
JJ |
denotes |
homozygous |
| T1102 |
485-492 |
NNS |
denotes |
mutants |
| T1103 |
493-499 |
VBD |
denotes |
showed |
| T1104 |
500-502 |
DT |
denotes |
no |
| T1105 |
512-519 |
NN |
denotes |
synergy |
| T1106 |
503-511 |
JJ |
denotes |
apparent |
| T1107 |
520-522 |
IN |
denotes |
in |
| T1108 |
523-532 |
NN |
denotes |
phenotype |
| T1109 |
533-541 |
NN |
denotes |
severity |
| T1110 |
541-542 |
. |
denotes |
. |
| T1111 |
542-722 |
sentence |
denotes |
The BAT-gal transgene reporter of canonical Wnt signaling showed reduced levels of expression in Pygo1-/-/Pygo2-/- mutants, with tissue-specific variation in degree of diminution. |
| T1112 |
543-546 |
DT |
denotes |
The |
| T1113 |
565-573 |
NN |
denotes |
reporter |
| T1114 |
547-550 |
NN |
denotes |
BAT |
| T1115 |
551-554 |
NN |
denotes |
gal |
| T1116 |
550-551 |
HYPH |
denotes |
- |
| T1117 |
555-564 |
NN |
denotes |
transgene |
| T1118 |
601-607 |
VBD |
denotes |
showed |
| T1119 |
574-576 |
IN |
denotes |
of |
| T1120 |
577-586 |
JJ |
denotes |
canonical |
| T1121 |
591-600 |
NN |
denotes |
signaling |
| T1122 |
587-590 |
NN |
denotes |
Wnt |
| T1123 |
608-615 |
VBN |
denotes |
reduced |
| T1124 |
616-622 |
NNS |
denotes |
levels |
| T1125 |
623-625 |
IN |
denotes |
of |
| T1126 |
626-636 |
NN |
denotes |
expression |
| T1127 |
637-639 |
IN |
denotes |
in |
| T1128 |
640-645 |
NN |
denotes |
Pygo1 |
| T1129 |
658-665 |
NNS |
denotes |
mutants |
| T1130 |
645-646 |
SYM |
denotes |
- |
| T1131 |
646-647 |
HYPH |
denotes |
/ |
| T1132 |
647-648 |
SYM |
denotes |
- |
| T1133 |
648-649 |
HYPH |
denotes |
/ |
| T1134 |
649-654 |
NN |
denotes |
Pygo2 |
| T1135 |
654-655 |
SYM |
denotes |
- |
| T1136 |
655-656 |
HYPH |
denotes |
/ |
| T1137 |
656-657 |
SYM |
denotes |
- |
| T1138 |
665-667 |
, |
denotes |
, |
| T1139 |
667-671 |
IN |
denotes |
with |
| T1140 |
672-678 |
NN |
denotes |
tissue |
| T1141 |
679-687 |
JJ |
denotes |
specific |
| T1142 |
678-679 |
HYPH |
denotes |
- |
| T1143 |
688-697 |
NN |
denotes |
variation |
| T1144 |
698-700 |
IN |
denotes |
in |
| T1145 |
701-707 |
NN |
denotes |
degree |
| T1146 |
708-710 |
IN |
denotes |
of |
| T1147 |
711-721 |
NN |
denotes |
diminution |
| T1148 |
721-722 |
. |
denotes |
. |
| T1149 |
722-860 |
sentence |
denotes |
The Pygo1 and Pygo2 genes both showed widespread expression in the developing kidney, with raised levels in the stromal cell compartment. |
| T1150 |
723-726 |
DT |
denotes |
The |
| T1151 |
743-748 |
NNS |
denotes |
genes |
| T1152 |
727-732 |
NN |
denotes |
Pygo1 |
| T1153 |
733-736 |
CC |
denotes |
and |
| T1154 |
737-742 |
NN |
denotes |
Pygo2 |
| T1155 |
754-760 |
VBD |
denotes |
showed |
| T1156 |
749-753 |
RB |
denotes |
both |
| T1157 |
761-771 |
JJ |
denotes |
widespread |
| T1158 |
772-782 |
NN |
denotes |
expression |
| T1159 |
783-785 |
IN |
denotes |
in |
| T1160 |
786-789 |
DT |
denotes |
the |
| T1161 |
801-807 |
NN |
denotes |
kidney |
| T1162 |
790-800 |
VBG |
denotes |
developing |
| T1163 |
807-809 |
, |
denotes |
, |
| T1164 |
809-813 |
IN |
denotes |
with |
| T1165 |
814-820 |
VBN |
denotes |
raised |
| T1166 |
821-827 |
NNS |
denotes |
levels |
| T1167 |
828-830 |
IN |
denotes |
in |
| T1168 |
831-834 |
DT |
denotes |
the |
| T1169 |
848-859 |
NN |
denotes |
compartment |
| T1170 |
835-842 |
JJ |
denotes |
stromal |
| T1171 |
843-847 |
NN |
denotes |
cell |
| T1172 |
859-860 |
. |
denotes |
. |
| T1173 |
860-1000 |
sentence |
denotes |
Confocal analysis of the double mutant kidneys showed disturbance of both the ureteric bud and metanephric mesenchyme-derived compartments. |
| T1174 |
861-869 |
JJ |
denotes |
Confocal |
| T1175 |
870-878 |
NN |
denotes |
analysis |
| T1176 |
908-914 |
VBD |
denotes |
showed |
| T1177 |
879-881 |
IN |
denotes |
of |
| T1178 |
882-885 |
DT |
denotes |
the |
| T1179 |
900-907 |
NNS |
denotes |
kidneys |
| T1180 |
886-892 |
JJ |
denotes |
double |
| T1181 |
893-899 |
NN |
denotes |
mutant |
| T1182 |
915-926 |
NN |
denotes |
disturbance |
| T1183 |
927-929 |
IN |
denotes |
of |
| T1184 |
930-934 |
CC |
denotes |
both |
| T1185 |
987-999 |
NNS |
denotes |
compartments |
| T1186 |
935-938 |
DT |
denotes |
the |
| T1187 |
939-947 |
JJ |
denotes |
ureteric |
| T1188 |
948-951 |
NN |
denotes |
bud |
| T1189 |
979-986 |
VBN |
denotes |
derived |
| T1190 |
952-955 |
CC |
denotes |
and |
| T1191 |
956-967 |
JJ |
denotes |
metanephric |
| T1192 |
968-978 |
NN |
denotes |
mesenchyme |
| T1193 |
978-979 |
HYPH |
denotes |
- |
| T1194 |
999-1000 |
. |
denotes |
. |
| T1195 |
1000-1165 |
sentence |
denotes |
Branching morphogenesis of the ureteric bud was altered, with expanded tips and reduced tip density, probably contributing to the smaller size of the mutant kidney. |
| T1196 |
1001-1010 |
VBG |
denotes |
Branching |
| T1197 |
1011-1024 |
NN |
denotes |
morphogenesis |
| T1198 |
1049-1056 |
VBN |
denotes |
altered |
| T1199 |
1025-1027 |
IN |
denotes |
of |
| T1200 |
1028-1031 |
DT |
denotes |
the |
| T1201 |
1041-1044 |
NN |
denotes |
bud |
| T1202 |
1032-1040 |
JJ |
denotes |
ureteric |
| T1203 |
1045-1048 |
VBD |
denotes |
was |
| T1204 |
1056-1058 |
, |
denotes |
, |
| T1205 |
1058-1062 |
IN |
denotes |
with |
| T1206 |
1063-1071 |
VBN |
denotes |
expanded |
| T1207 |
1072-1076 |
NNS |
denotes |
tips |
| T1208 |
1077-1080 |
CC |
denotes |
and |
| T1209 |
1081-1088 |
VBN |
denotes |
reduced |
| T1210 |
1093-1100 |
NN |
denotes |
density |
| T1211 |
1089-1092 |
NN |
denotes |
tip |
| T1212 |
1100-1102 |
, |
denotes |
, |
| T1213 |
1102-1110 |
RB |
denotes |
probably |
| T1214 |
1111-1123 |
VBG |
denotes |
contributing |
| T1215 |
1124-1126 |
IN |
denotes |
to |
| T1216 |
1127-1130 |
DT |
denotes |
the |
| T1217 |
1139-1143 |
NN |
denotes |
size |
| T1218 |
1131-1138 |
JJR |
denotes |
smaller |
| T1219 |
1144-1146 |
IN |
denotes |
of |
| T1220 |
1147-1150 |
DT |
denotes |
the |
| T1221 |
1158-1164 |
NN |
denotes |
kidney |
| T1222 |
1151-1157 |
NN |
denotes |
mutant |
| T1223 |
1164-1165 |
. |
denotes |
. |
| T1224 |
1165-1263 |
sentence |
denotes |
In addition, there was an expansion of the zone of condensed mesenchyme capping the ureteric bud. |
| T1225 |
1166-1168 |
IN |
denotes |
In |
| T1226 |
1185-1188 |
VBD |
denotes |
was |
| T1227 |
1169-1177 |
NN |
denotes |
addition |
| T1228 |
1177-1179 |
, |
denotes |
, |
| T1229 |
1179-1184 |
EX |
denotes |
there |
| T1230 |
1189-1191 |
DT |
denotes |
an |
| T1231 |
1192-1201 |
NN |
denotes |
expansion |
| T1232 |
1202-1204 |
IN |
denotes |
of |
| T1233 |
1205-1208 |
DT |
denotes |
the |
| T1234 |
1209-1213 |
NN |
denotes |
zone |
| T1235 |
1214-1216 |
IN |
denotes |
of |
| T1236 |
1217-1226 |
VBN |
denotes |
condensed |
| T1237 |
1227-1237 |
NN |
denotes |
mesenchyme |
| T1238 |
1238-1245 |
VBG |
denotes |
capping |
| T1239 |
1246-1249 |
DT |
denotes |
the |
| T1240 |
1259-1262 |
NN |
denotes |
bud |
| T1241 |
1250-1258 |
JJ |
denotes |
ureteric |
| T1242 |
1262-1263 |
. |
denotes |
. |
| T1243 |
1263-1311 |
sentence |
denotes |
Nephron formation, however, proceeded normally. |
| T1244 |
1264-1271 |
NN |
denotes |
Nephron |
| T1245 |
1272-1281 |
NN |
denotes |
formation |
| T1246 |
1292-1301 |
VBD |
denotes |
proceeded |
| T1247 |
1281-1283 |
, |
denotes |
, |
| T1248 |
1283-1290 |
RB |
denotes |
however |
| T1249 |
1290-1292 |
, |
denotes |
, |
| T1250 |
1302-1310 |
RB |
denotes |
normally |
| T1251 |
1310-1311 |
. |
denotes |
. |
| T1252 |
1311-1487 |
sentence |
denotes |
Microarray analysis showed changed expression of several genes, including Cxcl13, Slc5a2, Klk5, Ren2 and Timeless, which represent candidate Wnt targets in kidney development. |
| T1253 |
1312-1322 |
NN |
denotes |
Microarray |
| T1254 |
1323-1331 |
NN |
denotes |
analysis |
| T1255 |
1332-1338 |
VBD |
denotes |
showed |
| T1256 |
1339-1346 |
VBN |
denotes |
changed |
| T1257 |
1347-1357 |
NN |
denotes |
expression |
| T1258 |
1358-1360 |
IN |
denotes |
of |
| T1259 |
1361-1368 |
JJ |
denotes |
several |
| T1260 |
1369-1374 |
NNS |
denotes |
genes |
| T1261 |
1374-1376 |
, |
denotes |
, |
| T1262 |
1376-1385 |
VBG |
denotes |
including |
| T1263 |
1386-1392 |
NN |
denotes |
Cxcl13 |
| T1264 |
1392-1394 |
, |
denotes |
, |
| T1265 |
1394-1400 |
NN |
denotes |
Slc5a2 |
| T1266 |
1400-1402 |
, |
denotes |
, |
| T1267 |
1402-1406 |
NN |
denotes |
Klk5 |
| T1268 |
1406-1408 |
, |
denotes |
, |
| T1269 |
1408-1412 |
NN |
denotes |
Ren2 |
| T1270 |
1413-1416 |
CC |
denotes |
and |
| T1271 |
1417-1425 |
NN |
denotes |
Timeless |
| T1272 |
1425-1427 |
, |
denotes |
, |
| T1273 |
1427-1432 |
WDT |
denotes |
which |
| T1274 |
1433-1442 |
VBP |
denotes |
represent |
| T1275 |
1443-1452 |
NN |
denotes |
candidate |
| T1276 |
1457-1464 |
NNS |
denotes |
targets |
| T1277 |
1453-1456 |
NN |
denotes |
Wnt |
| T1278 |
1465-1467 |
IN |
denotes |
in |
| T1279 |
1468-1474 |
NN |
denotes |
kidney |
| T1280 |
1475-1486 |
NN |
denotes |
development |
| T1281 |
1486-1487 |
. |
denotes |
. |
| R67 |
T1016 |
T1017 |
det |
Each,mutation |
| R68 |
T1017 |
T1018 |
nsubj |
mutation,resulted |
| R69 |
T1019 |
T1018 |
aux |
deleted,resulted |
| R70 |
T1020 |
T1021 |
punct |
>,80 |
| R71 |
T1021 |
T1022 |
nummod |
80,% |
| R72 |
T1022 |
T1018 |
dobj |
%,resulted |
| R73 |
T1023 |
T1022 |
prep |
of,% |
| R74 |
T1024 |
T1025 |
det |
the,sequence |
| R75 |
T1025 |
T1023 |
pobj |
sequence,of |
| R76 |
T1026 |
T1025 |
compound |
coding,sequence |
| R77 |
T1027 |
T1022 |
punct |
", ",% |
| R78 |
T1028 |
T1022 |
prep |
including,% |
| R79 |
T1029 |
T1030 |
det |
the,domain |
| R80 |
T1030 |
T1028 |
pobj |
domain,including |
| R81 |
T1031 |
T1030 |
amod |
critical,domain |
| R82 |
T1032 |
T1030 |
compound |
PHD,domain |
| R83 |
T1033 |
T1018 |
punct |
", ",resulted |
| R84 |
T1034 |
T1018 |
cc |
and,resulted |
| R85 |
T1035 |
T1036 |
advmod |
almost,certainly |
| R86 |
T1036 |
T1018 |
advmod |
certainly,resulted |
| R87 |
T1037 |
T1018 |
prep |
in,resulted |
| R88 |
T1038 |
T1039 |
amod |
null,function |
| R89 |
T1039 |
T1037 |
pobj |
function,in |
| R90 |
T1040 |
T1018 |
punct |
.,resulted |
| R91 |
T1042 |
T1043 |
npadvmod |
Pygo2,homozygous |
| R92 |
T1043 |
T1044 |
amod |
homozygous,mutants |
| R93 |
T1044 |
T1045 |
nsubj |
mutants,died |
| R94 |
T1046 |
T1045 |
punct |
", ",died |
| R95 |
T1047 |
T1045 |
prep |
with,died |
| R96 |
T1048 |
T1049 |
amod |
rare,exception |
| R97 |
T1049 |
T1047 |
pobj |
exception,with |
| R98 |
T1050 |
T1045 |
punct |
", ",died |
| R99 |
T1051 |
T1052 |
advmod |
shortly,after |
| R100 |
T1052 |
T1045 |
prep |
after,died |
| R101 |
T1053 |
T1052 |
pobj |
birth,after |
| R102 |
T1054 |
T1045 |
punct |
", ",died |
| R103 |
T1055 |
T1045 |
prep |
with,died |
| R104 |
T1056 |
T1057 |
det |
a,phenotype |
| R105 |
T1057 |
T1055 |
pobj |
phenotype,with |
| R106 |
T1058 |
T1057 |
prep |
including,phenotype |
| R107 |
T1059 |
T1060 |
compound |
lens,agenesis |
| R108 |
T1060 |
T1058 |
pobj |
agenesis,including |
| R109 |
T1061 |
T1060 |
punct |
", ",agenesis |
| R110 |
T1062 |
T1063 |
compound |
growth,retardation |
| R111 |
T1063 |
T1060 |
conj |
retardation,agenesis |
| R112 |
T1064 |
T1063 |
punct |
", ",retardation |
| R113 |
T1065 |
T1066 |
amod |
altered,development |
| R114 |
T1066 |
T1063 |
conj |
development,retardation |
| R115 |
T1067 |
T1066 |
compound |
kidney,development |
| R116 |
T1068 |
T1066 |
punct |
", ",development |
| R117 |
T1069 |
T1066 |
cc |
and,development |
| R118 |
T1070 |
T1071 |
prep |
in,exencephaly |
| R119 |
T1071 |
T1066 |
conj |
exencephaly,development |
| R120 |
T1072 |
T1073 |
det |
some,cases |
| R121 |
T1073 |
T1070 |
pobj |
cases,in |
| R122 |
T1074 |
T1071 |
cc |
and,exencephaly |
| R123 |
T1075 |
T1076 |
amod |
cleft,palate |
| R124 |
T1076 |
T1071 |
conj |
palate,exencephaly |
| R125 |
T1077 |
T1045 |
punct |
.,died |
| R126 |
T1079 |
T1080 |
npadvmod |
Pygo1,homozygous |
| R127 |
T1080 |
T1081 |
amod |
homozygous,mutants |
| R128 |
T1081 |
T1082 |
nsubj |
mutants,were |
| R129 |
T1083 |
T1082 |
punct |
", ",were |
| R130 |
T1084 |
T1082 |
advmod |
however,were |
| R131 |
T1085 |
T1082 |
punct |
", ",were |
| R132 |
T1086 |
T1082 |
acomp |
viable,were |
| R133 |
T1087 |
T1086 |
cc |
and,viable |
| R134 |
T1088 |
T1086 |
conj |
fertile,viable |
| R135 |
T1089 |
T1082 |
punct |
", ",were |
| R136 |
T1090 |
T1082 |
prep |
with,were |
| R137 |
T1091 |
T1092 |
det |
no,defects |
| R138 |
T1092 |
T1090 |
pobj |
defects,with |
| R139 |
T1093 |
T1092 |
amod |
detectable,defects |
| R140 |
T1094 |
T1092 |
amod |
developmental,defects |
| R141 |
T1095 |
T1082 |
punct |
.,were |
| R142 |
T1097 |
T1098 |
amod |
Double,Pygo2 |
| R143 |
T1098 |
T1101 |
npadvmod |
Pygo2,homozygous |
| R144 |
T1099 |
T1098 |
compound |
Pygo1,Pygo2 |
| R145 |
T1100 |
T1098 |
punct |
/,Pygo2 |
| R146 |
T1101 |
T1102 |
amod |
homozygous,mutants |
| R147 |
T1102 |
T1103 |
nsubj |
mutants,showed |
| R148 |
T1104 |
T1105 |
det |
no,synergy |
| R149 |
T1105 |
T1103 |
dobj |
synergy,showed |
| R150 |
T1106 |
T1105 |
amod |
apparent,synergy |
| R151 |
T1107 |
T1105 |
prep |
in,synergy |
| R152 |
T1108 |
T1109 |
compound |
phenotype,severity |
| R153 |
T1109 |
T1107 |
pobj |
severity,in |
| R154 |
T1110 |
T1103 |
punct |
.,showed |
| R155 |
T1112 |
T1113 |
det |
The,reporter |
| R156 |
T1113 |
T1118 |
nsubj |
reporter,showed |
| R157 |
T1114 |
T1115 |
compound |
BAT,gal |
| R158 |
T1115 |
T1117 |
compound |
gal,transgene |
| R159 |
T1116 |
T1115 |
punct |
-,gal |
| R160 |
T1117 |
T1113 |
compound |
transgene,reporter |
| R161 |
T1119 |
T1113 |
prep |
of,reporter |
| R162 |
T1120 |
T1121 |
amod |
canonical,signaling |
| R163 |
T1121 |
T1119 |
pobj |
signaling,of |
| R164 |
T1122 |
T1121 |
compound |
Wnt,signaling |
| R165 |
T1123 |
T1124 |
amod |
reduced,levels |
| R166 |
T1124 |
T1118 |
dobj |
levels,showed |
| R167 |
T1125 |
T1124 |
prep |
of,levels |
| R168 |
T1126 |
T1125 |
pobj |
expression,of |
| R169 |
T1127 |
T1124 |
prep |
in,levels |
| R170 |
T1128 |
T1129 |
nmod |
Pygo1,mutants |
| R171 |
T1129 |
T1127 |
pobj |
mutants,in |
| R172 |
T1130 |
T1128 |
punct |
-,Pygo1 |
| R173 |
T1131 |
T1128 |
punct |
/,Pygo1 |
| R174 |
T1132 |
T1128 |
punct |
-,Pygo1 |
| R175 |
T1133 |
T1128 |
punct |
/,Pygo1 |
| R176 |
T1134 |
T1128 |
appos |
Pygo2,Pygo1 |
| R177 |
T1135 |
T1134 |
punct |
-,Pygo2 |
| R178 |
T1136 |
T1134 |
punct |
/,Pygo2 |
| R179 |
T1137 |
T1134 |
punct |
-,Pygo2 |
| R180 |
T1138 |
T1118 |
punct |
", ",showed |
| R181 |
T1139 |
T1118 |
prep |
with,showed |
| R182 |
T1140 |
T1141 |
npadvmod |
tissue,specific |
| R183 |
T1141 |
T1143 |
amod |
specific,variation |
| R184 |
T1142 |
T1141 |
punct |
-,specific |
| R185 |
T1143 |
T1139 |
pobj |
variation,with |
| R186 |
T1144 |
T1143 |
prep |
in,variation |
| R187 |
T1145 |
T1144 |
pobj |
degree,in |
| R188 |
T1146 |
T1145 |
prep |
of,degree |
| R189 |
T1147 |
T1146 |
pobj |
diminution,of |
| R190 |
T1148 |
T1118 |
punct |
.,showed |
| R191 |
T1150 |
T1151 |
det |
The,genes |
| R193 |
T1152 |
T1151 |
nmod |
Pygo1,genes |
| R194 |
T1153 |
T1152 |
cc |
and,Pygo1 |
| R195 |
T1154 |
T1152 |
conj |
Pygo2,Pygo1 |
| R196 |
T1156 |
T1151 |
appos |
both,genes |
| R197 |
T1157 |
T1158 |
amod |
widespread,expression |
| R198 |
T1158 |
T1155 |
dobj |
expression,showed |
| R199 |
T1159 |
T1158 |
prep |
in,expression |
| R200 |
T1160 |
T1161 |
det |
the,kidney |
| R201 |
T1161 |
T1159 |
pobj |
kidney,in |
| R202 |
T1162 |
T1161 |
amod |
developing,kidney |
| R203 |
T1163 |
T1155 |
punct |
", ",showed |
| R204 |
T1164 |
T1155 |
prep |
with,showed |
| R205 |
T1165 |
T1166 |
amod |
raised,levels |
| R206 |
T1166 |
T1164 |
pobj |
levels,with |
| R207 |
T1167 |
T1166 |
prep |
in,levels |
| R208 |
T1168 |
T1169 |
det |
the,compartment |
| R209 |
T1169 |
T1167 |
pobj |
compartment,in |
| R210 |
T1170 |
T1171 |
amod |
stromal,cell |
| R211 |
T1171 |
T1169 |
compound |
cell,compartment |
| R212 |
T1172 |
T1155 |
punct |
.,showed |
| R213 |
T1174 |
T1175 |
amod |
Confocal,analysis |
| R214 |
T1175 |
T1176 |
nsubj |
analysis,showed |
| R215 |
T1177 |
T1175 |
prep |
of,analysis |
| R216 |
T1178 |
T1179 |
det |
the,kidneys |
| R217 |
T1179 |
T1177 |
pobj |
kidneys,of |
| R218 |
T1180 |
T1181 |
amod |
double,mutant |
| R219 |
T1181 |
T1179 |
compound |
mutant,kidneys |
| R220 |
T1182 |
T1176 |
dobj |
disturbance,showed |
| R221 |
T1183 |
T1182 |
prep |
of,disturbance |
| R222 |
T1184 |
T1185 |
preconj |
both,compartments |
| R223 |
T1185 |
T1183 |
pobj |
compartments,of |
| R224 |
T1186 |
T1185 |
det |
the,compartments |
| R225 |
T1187 |
T1188 |
amod |
ureteric,bud |
| R226 |
T1188 |
T1189 |
npadvmod |
bud,derived |
| R228 |
T1190 |
T1188 |
cc |
and,bud |
| R229 |
T1191 |
T1192 |
amod |
metanephric,mesenchyme |
| R230 |
T1192 |
T1188 |
conj |
mesenchyme,bud |
| R231 |
T1193 |
T1189 |
punct |
-,derived |
| R232 |
T1194 |
T1176 |
punct |
.,showed |
| R233 |
T1196 |
T1197 |
amod |
Branching,morphogenesis |
| R234 |
T1197 |
T1198 |
nsubjpass |
morphogenesis,altered |
| R235 |
T1199 |
T1197 |
prep |
of,morphogenesis |
| R236 |
T1200 |
T1201 |
det |
the,bud |
| R237 |
T1201 |
T1199 |
pobj |
bud,of |
| R238 |
T1202 |
T1201 |
amod |
ureteric,bud |
| R239 |
T1203 |
T1198 |
auxpass |
was,altered |
| R240 |
T1204 |
T1198 |
punct |
", ",altered |
| R241 |
T1205 |
T1198 |
prep |
with,altered |
| R242 |
T1206 |
T1207 |
amod |
expanded,tips |
| R243 |
T1207 |
T1205 |
pobj |
tips,with |
| R244 |
T1208 |
T1207 |
cc |
and,tips |
| R245 |
T1209 |
T1210 |
amod |
reduced,density |
| R246 |
T1210 |
T1207 |
conj |
density,tips |
| R247 |
T1211 |
T1210 |
compound |
tip,density |
| R248 |
T1212 |
T1198 |
punct |
", ",altered |
| R249 |
T1213 |
T1214 |
advmod |
probably,contributing |
| R250 |
T1214 |
T1198 |
advcl |
contributing,altered |
| R251 |
T1215 |
T1214 |
prep |
to,contributing |
| R252 |
T1216 |
T1217 |
det |
the,size |
| R253 |
T1217 |
T1215 |
pobj |
size,to |
| R254 |
T1218 |
T1217 |
amod |
smaller,size |
| R255 |
T1219 |
T1217 |
prep |
of,size |
| R256 |
T1220 |
T1221 |
det |
the,kidney |
| R257 |
T1221 |
T1219 |
pobj |
kidney,of |
| R258 |
T1222 |
T1221 |
compound |
mutant,kidney |
| R259 |
T1223 |
T1198 |
punct |
.,altered |
| R260 |
T1225 |
T1226 |
prep |
In,was |
| R261 |
T1227 |
T1225 |
pobj |
addition,In |
| R262 |
T1228 |
T1226 |
punct |
", ",was |
| R263 |
T1229 |
T1226 |
expl |
there,was |
| R264 |
T1230 |
T1231 |
det |
an,expansion |
| R265 |
T1231 |
T1226 |
attr |
expansion,was |
| R266 |
T1232 |
T1231 |
prep |
of,expansion |
| R267 |
T1233 |
T1234 |
det |
the,zone |
| R268 |
T1234 |
T1232 |
pobj |
zone,of |
| R269 |
T1235 |
T1234 |
prep |
of,zone |
| R270 |
T1236 |
T1237 |
amod |
condensed,mesenchyme |
| R271 |
T1237 |
T1235 |
pobj |
mesenchyme,of |
| R272 |
T1238 |
T1234 |
acl |
capping,zone |
| R273 |
T1239 |
T1240 |
det |
the,bud |
| R274 |
T1240 |
T1238 |
dobj |
bud,capping |
| R275 |
T1241 |
T1240 |
amod |
ureteric,bud |
| R276 |
T1242 |
T1226 |
punct |
.,was |
| R277 |
T1244 |
T1245 |
compound |
Nephron,formation |
| R278 |
T1245 |
T1246 |
nsubj |
formation,proceeded |
| R279 |
T1247 |
T1246 |
punct |
", ",proceeded |
| R280 |
T1248 |
T1246 |
advmod |
however,proceeded |
| R281 |
T1249 |
T1246 |
punct |
", ",proceeded |
| R282 |
T1250 |
T1246 |
advmod |
normally,proceeded |
| R283 |
T1251 |
T1246 |
punct |
.,proceeded |
| R284 |
T1253 |
T1254 |
compound |
Microarray,analysis |
| R285 |
T1254 |
T1255 |
nsubj |
analysis,showed |
| R286 |
T1256 |
T1257 |
amod |
changed,expression |
| R287 |
T1257 |
T1255 |
dobj |
expression,showed |
| R288 |
T1258 |
T1257 |
prep |
of,expression |
| R289 |
T1259 |
T1260 |
amod |
several,genes |
| R290 |
T1260 |
T1258 |
pobj |
genes,of |
| R291 |
T1261 |
T1260 |
punct |
", ",genes |
| R292 |
T1262 |
T1260 |
prep |
including,genes |
| R293 |
T1263 |
T1262 |
pobj |
Cxcl13,including |
| R294 |
T1264 |
T1263 |
punct |
", ",Cxcl13 |
| R295 |
T1265 |
T1263 |
conj |
Slc5a2,Cxcl13 |
| R296 |
T1266 |
T1265 |
punct |
", ",Slc5a2 |
| R297 |
T1267 |
T1265 |
conj |
Klk5,Slc5a2 |
| R298 |
T1268 |
T1267 |
punct |
", ",Klk5 |
| R299 |
T1269 |
T1267 |
conj |
Ren2,Klk5 |
| R300 |
T1270 |
T1269 |
cc |
and,Ren2 |
| R301 |
T1271 |
T1269 |
conj |
Timeless,Ren2 |
| R302 |
T1272 |
T1260 |
punct |
", ",genes |
| R303 |
T1273 |
T1274 |
dep |
which,represent |
| R304 |
T1274 |
T1260 |
relcl |
represent,genes |
| R305 |
T1275 |
T1276 |
compound |
candidate,targets |
| R306 |
T1276 |
T1274 |
dobj |
targets,represent |
| R307 |
T1277 |
T1276 |
compound |
Wnt,targets |
| R308 |
T1278 |
T1276 |
prep |
in,targets |
| R309 |
T1279 |
T1280 |
compound |
kidney,development |
| R310 |
T1280 |
T1278 |
pobj |
development,in |
| R311 |
T1281 |
T1255 |
punct |
.,showed |
| R192 |
T1151 |
T1155 |
nsubj |
genes,showed |
| R227 |
T1189 |
T1185 |
amod |
derived,compartments |