Id |
Subject |
Object |
Predicate |
Lexical cue |
T12466 |
794-795 |
. |
denotes |
. |
T12465 |
793-794 |
-RRB- |
denotes |
] |
T12464 |
791-793 |
CD |
denotes |
28 |
T12463 |
790-791 |
-LRB- |
denotes |
[ |
T12462 |
766-775 |
NN |
denotes |
branching |
T12461 |
776-789 |
NN |
denotes |
morphogenesis |
T12460 |
757-765 |
JJ |
denotes |
ureteric |
T12459 |
748-756 |
VB |
denotes |
regulate |
T12458 |
745-747 |
TO |
denotes |
to |
T12457 |
734-738 |
VBN |
denotes |
been |
T12456 |
729-733 |
RB |
denotes |
also |
T12455 |
725-728 |
VBZ |
denotes |
has |
T12454 |
723-725 |
, |
denotes |
, |
T12453 |
710-718 |
JJ |
denotes |
ureteric |
T12452 |
700-709 |
VBG |
denotes |
branching |
T12451 |
719-723 |
NNS |
denotes |
tips |
T12450 |
696-699 |
DT |
denotes |
the |
T12449 |
693-695 |
IN |
denotes |
in |
T12448 |
683-692 |
VBN |
denotes |
expressed |
T12447 |
679-682 |
CC |
denotes |
and |
T12446 |
677-679 |
, |
denotes |
, |
T12445 |
670-677 |
NNS |
denotes |
rhythms |
T12444 |
660-669 |
JJ |
denotes |
circadian |
T12443 |
657-659 |
IN |
denotes |
of |
T12442 |
646-656 |
NN |
denotes |
regulation |
T12441 |
642-645 |
DT |
denotes |
the |
T12440 |
639-641 |
IN |
denotes |
in |
T12439 |
630-638 |
VBN |
denotes |
involved |
T12438 |
609-622 |
NN |
denotes |
transcription |
T12437 |
623-629 |
NN |
denotes |
factor |
T12436 |
607-608 |
DT |
denotes |
a |
T12435 |
605-607 |
, |
denotes |
, |
T12434 |
739-744 |
VBN |
denotes |
shown |
T12398 |
418-420 |
, |
denotes |
, |
T12397 |
399-400 |
HYPH |
denotes |
- |
T12396 |
400-411 |
NN |
denotes |
angiotensin |
T12395 |
394-399 |
NN |
denotes |
renin |
T12394 |
412-418 |
NN |
denotes |
system |
T12393 |
390-393 |
DT |
denotes |
the |
T12392 |
378-380 |
, |
denotes |
, |
T12391 |
377-378 |
CD |
denotes |
1 |
T12390 |
371-376 |
NN |
denotes |
Renin |
T12389 |
357-370 |
NN |
denotes |
endopeptidase |
T12388 |
353-356 |
DT |
denotes |
the |
T12387 |
350-352 |
IN |
denotes |
of |
T12386 |
342-349 |
NN |
denotes |
homolog |
T12385 |
340-341 |
DT |
denotes |
a |
T12384 |
338-340 |
, |
denotes |
, |
T12383 |
380-389 |
VBZ |
denotes |
activates |
T12382 |
334-338 |
NN |
denotes |
Ren2 |
T12381 |
333-451 |
sentence |
denotes |
Ren2, a homolog of the endopeptidase Renin 1, activates the renin-angiotensin system, increasing blood pressure [26]. |
T12380 |
332-333 |
. |
denotes |
. |
T12379 |
331-332 |
-RRB- |
denotes |
] |
T12378 |
329-331 |
CD |
denotes |
25 |
T12377 |
328-329 |
-LRB- |
denotes |
[ |
T12376 |
319-327 |
NN |
denotes |
pressure |
T12375 |
313-318 |
NN |
denotes |
blood |
T12374 |
310-312 |
IN |
denotes |
of |
T12373 |
299-309 |
NN |
denotes |
regulation |
T12372 |
295-298 |
CC |
denotes |
and |
T12371 |
293-295 |
, |
denotes |
, |
T12370 |
283-293 |
NN |
denotes |
remodeling |
T12369 |
276-282 |
NN |
denotes |
tissue |
T12368 |
274-276 |
, |
denotes |
, |
T12367 |
268-274 |
NN |
denotes |
cancer |
T12366 |
265-267 |
IN |
denotes |
in |
T12365 |
255-264 |
NNS |
denotes |
functions |
T12364 |
247-254 |
JJ |
denotes |
diverse |
T12363 |
242-246 |
VBP |
denotes |
have |
T12361 |
229-333 |
sentence |
denotes |
Kallikreins have diverse functions in cancer, tissue remodeling, and regulation of blood pressure [25]. |
T12360 |
228-229 |
. |
denotes |
. |
T12359 |
212-218 |
NN |
denotes |
serine |
T12358 |
219-228 |
NNS |
denotes |
proteases |
T12357 |
206-207 |
HYPH |
denotes |
- |
T12356 |
207-211 |
JJ |
denotes |
like |
T12355 |
199-206 |
NN |
denotes |
trypsin |
T12354 |
196-198 |
IN |
denotes |
of |
T12353 |
178-188 |
NN |
denotes |
kallikrein |
T12352 |
189-195 |
NN |
denotes |
family |
T12351 |
174-177 |
DT |
denotes |
the |
T12350 |
171-173 |
IN |
denotes |
of |
T12349 |
163-170 |
NNS |
denotes |
members |
T12348 |
154-158 |
NN |
denotes |
Klk6 |
T12347 |
150-153 |
CC |
denotes |
and |
T12346 |
159-162 |
VBP |
denotes |
are |
T12345 |
145-149 |
NN |
denotes |
Klk5 |
T12344 |
144-229 |
sentence |
denotes |
Klk5 and Klk6 are members of the kallikrein family of trypsin-like serine proteases. |
T12343 |
143-144 |
. |
denotes |
. |
T12342 |
142-143 |
-RRB- |
denotes |
) |
T12341 |
134-142 |
RB |
denotes |
2.4-fold |
T12340 |
133-134 |
-LRB- |
denotes |
( |
T12339 |
124-132 |
NNP |
denotes |
Timeless |
T12338 |
120-123 |
CC |
denotes |
and |
T12337 |
118-120 |
, |
denotes |
, |
T12336 |
117-118 |
-RRB- |
denotes |
) |
T12335 |
109-117 |
RB |
denotes |
2.2-fold |
T12334 |
108-109 |
-LRB- |
denotes |
( |
T12333 |
103-107 |
NN |
denotes |
Ren2 |
T12332 |
101-103 |
, |
denotes |
, |
T12331 |
100-101 |
-RRB- |
denotes |
) |
T12330 |
92-100 |
RB |
denotes |
2.7-fold |
T12329 |
91-92 |
-LRB- |
denotes |
( |
T12328 |
86-90 |
NN |
denotes |
Klk6 |
T12327 |
84-86 |
, |
denotes |
, |
T12326 |
83-84 |
-RRB- |
denotes |
) |
T12325 |
75-83 |
RB |
denotes |
2.8-fold |
T12324 |
74-75 |
-LRB- |
denotes |
( |
T12323 |
69-73 |
NN |
denotes |
Klk5 |
T12322 |
48-52 |
JJ |
denotes |
null |
T12321 |
41-42 |
HYPH |
denotes |
/ |
T12320 |
42-47 |
NN |
denotes |
Pygo2 |
T12319 |
36-41 |
NN |
denotes |
Pygo1 |
T12318 |
53-59 |
NN |
denotes |
kidney |
T12317 |
32-35 |
DT |
denotes |
the |
T12433 |
597-605 |
NN |
denotes |
Timeless |
T12432 |
596-795 |
sentence |
denotes |
Timeless, a transcription factor involved in the regulation of circadian rhythms, and expressed in the branching ureteric tips, has also been shown to regulate ureteric branching morphogenesis [28]. |
T12431 |
595-596 |
. |
denotes |
. |
T12430 |
594-595 |
-RRB- |
denotes |
] |
T12429 |
592-594 |
CD |
denotes |
27 |
T12428 |
591-592 |
-LRB- |
denotes |
[ |
T12427 |
584-590 |
NN |
denotes |
system |
T12426 |
578-579 |
HYPH |
denotes |
- |
T12425 |
579-583 |
NN |
denotes |
duct |
T12424 |
568-578 |
NN |
denotes |
collecting |
T12423 |
564-567 |
CC |
denotes |
and |
T12422 |
557-563 |
NN |
denotes |
ureter |
T12421 |
553-556 |
DT |
denotes |
the |
T12420 |
550-552 |
IN |
denotes |
of |
T12419 |
536-549 |
NNS |
denotes |
abnormalities |
T12418 |
525-535 |
JJ |
denotes |
congenital |
T12417 |
522-524 |
IN |
denotes |
in |
T12416 |
502-513 |
NN |
denotes |
development |
T12415 |
495-501 |
IN |
denotes |
during |
T12414 |
475-476 |
HYPH |
denotes |
- |
T12413 |
476-487 |
NN |
denotes |
angiotensin |
T12412 |
470-475 |
NN |
denotes |
renin |
T12411 |
488-494 |
NN |
denotes |
system |
T12410 |
466-469 |
DT |
denotes |
the |
T12409 |
463-465 |
IN |
denotes |
of |
T12408 |
514-521 |
VBZ |
denotes |
results |
T12407 |
452-462 |
NN |
denotes |
Disruption |
T12406 |
451-596 |
sentence |
denotes |
Disruption of the renin-angiotensin system during development results in congenital abnormalities of the ureter and collecting-duct system [27]. |
T12405 |
450-451 |
. |
denotes |
. |
T12404 |
449-450 |
-RRB- |
denotes |
] |
T12403 |
447-449 |
CD |
denotes |
26 |
T12402 |
446-447 |
-LRB- |
denotes |
[ |
T12401 |
437-445 |
NN |
denotes |
pressure |
T12400 |
431-436 |
NN |
denotes |
blood |
T12399 |
420-430 |
VBG |
denotes |
increasing |
T12316 |
29-31 |
IN |
denotes |
in |
T12315 |
17-28 |
VBN |
denotes |
upregulated |
T12314 |
60-68 |
VBN |
denotes |
included |
T12313 |
11-16 |
NNS |
denotes |
genes |
T12312 |
0-10 |
JJ |
denotes |
Noteworthy |
T12311 |
0-144 |
sentence |
denotes |
Noteworthy genes upregulated in the Pygo1/Pygo2 null kidney included Klk5 (2.8-fold), Klk6 (2.7-fold), Ren2 (2.2-fold), and Timeless (2.4-fold). |
T12362 |
230-241 |
NNS |
denotes |
Kallikreins |
R3269 |
T12312 |
T12313 |
amod |
Noteworthy,genes |
R3270 |
T12313 |
T12314 |
nsubj |
genes,included |
R3271 |
T12315 |
T12313 |
acl |
upregulated,genes |
R3272 |
T12316 |
T12315 |
prep |
in,upregulated |
R3273 |
T12317 |
T12318 |
det |
the,kidney |
R3274 |
T12318 |
T12316 |
pobj |
kidney,in |
R3275 |
T12319 |
T12320 |
compound |
Pygo1,Pygo2 |
R3276 |
T12320 |
T12322 |
npadvmod |
Pygo2,null |
R3277 |
T12321 |
T12320 |
punct |
/,Pygo2 |
R3278 |
T12322 |
T12318 |
amod |
null,kidney |
R3279 |
T12323 |
T12314 |
dobj |
Klk5,included |
R3280 |
T12324 |
T12325 |
punct |
(,2.8-fold |
R3281 |
T12325 |
T12323 |
parataxis |
2.8-fold,Klk5 |
R3282 |
T12326 |
T12325 |
punct |
),2.8-fold |
R3283 |
T12327 |
T12323 |
punct |
", ",Klk5 |
R3284 |
T12328 |
T12323 |
conj |
Klk6,Klk5 |
R3285 |
T12329 |
T12330 |
punct |
(,2.7-fold |
R3286 |
T12330 |
T12328 |
parataxis |
2.7-fold,Klk6 |
R3287 |
T12331 |
T12330 |
punct |
),2.7-fold |
R3288 |
T12332 |
T12328 |
punct |
", ",Klk6 |
R3289 |
T12333 |
T12328 |
conj |
Ren2,Klk6 |
R3290 |
T12334 |
T12335 |
punct |
(,2.2-fold |
R3291 |
T12335 |
T12333 |
parataxis |
2.2-fold,Ren2 |
R3292 |
T12336 |
T12335 |
punct |
),2.2-fold |
R3293 |
T12337 |
T12333 |
punct |
", ",Ren2 |
R3294 |
T12338 |
T12333 |
cc |
and,Ren2 |
R3295 |
T12339 |
T12333 |
conj |
Timeless,Ren2 |
R3296 |
T12340 |
T12341 |
punct |
(,2.4-fold |
R3297 |
T12341 |
T12339 |
parataxis |
2.4-fold,Timeless |
R3298 |
T12342 |
T12341 |
punct |
),2.4-fold |
R3299 |
T12343 |
T12314 |
punct |
.,included |
R3300 |
T12345 |
T12346 |
nsubj |
Klk5,are |
R3301 |
T12347 |
T12345 |
cc |
and,Klk5 |
R3302 |
T12348 |
T12345 |
conj |
Klk6,Klk5 |
R3303 |
T12349 |
T12346 |
attr |
members,are |
R3304 |
T12350 |
T12349 |
prep |
of,members |
R3305 |
T12351 |
T12352 |
det |
the,family |
R3306 |
T12352 |
T12350 |
pobj |
family,of |
R3307 |
T12353 |
T12352 |
compound |
kallikrein,family |
R3308 |
T12354 |
T12352 |
prep |
of,family |
R3309 |
T12355 |
T12356 |
npadvmod |
trypsin,like |
R3310 |
T12356 |
T12358 |
amod |
like,proteases |
R3311 |
T12357 |
T12356 |
punct |
-,like |
R3312 |
T12358 |
T12354 |
pobj |
proteases,of |
R3313 |
T12359 |
T12358 |
compound |
serine,proteases |
R3314 |
T12360 |
T12346 |
punct |
.,are |
R3315 |
T12362 |
T12363 |
nsubj |
Kallikreins,have |
R3316 |
T12364 |
T12365 |
amod |
diverse,functions |
R3317 |
T12365 |
T12363 |
dobj |
functions,have |
R3318 |
T12366 |
T12363 |
prep |
in,have |
R3319 |
T12367 |
T12366 |
pobj |
cancer,in |
R3320 |
T12368 |
T12367 |
punct |
", ",cancer |
R3321 |
T12369 |
T12370 |
compound |
tissue,remodeling |
R3322 |
T12370 |
T12367 |
conj |
remodeling,cancer |
R3323 |
T12371 |
T12370 |
punct |
", ",remodeling |
R3324 |
T12372 |
T12370 |
cc |
and,remodeling |
R3325 |
T12373 |
T12370 |
conj |
regulation,remodeling |
R3326 |
T12374 |
T12373 |
prep |
of,regulation |
R3327 |
T12375 |
T12376 |
compound |
blood,pressure |
R3328 |
T12376 |
T12374 |
pobj |
pressure,of |
R3329 |
T12377 |
T12378 |
punct |
[,25 |
R3330 |
T12378 |
T12363 |
parataxis |
25,have |
R3331 |
T12379 |
T12378 |
punct |
],25 |
R3332 |
T12380 |
T12363 |
punct |
.,have |
R3333 |
T12382 |
T12383 |
nsubj |
Ren2,activates |
R3334 |
T12384 |
T12382 |
punct |
", ",Ren2 |
R3335 |
T12385 |
T12386 |
det |
a,homolog |
R3336 |
T12386 |
T12382 |
appos |
homolog,Ren2 |
R3337 |
T12387 |
T12386 |
prep |
of,homolog |
R3338 |
T12388 |
T12389 |
det |
the,endopeptidase |
R3339 |
T12389 |
T12387 |
pobj |
endopeptidase,of |
R3340 |
T12390 |
T12389 |
appos |
Renin,endopeptidase |
R3341 |
T12391 |
T12390 |
nummod |
1,Renin |
R3342 |
T12392 |
T12383 |
punct |
", ",activates |
R3343 |
T12393 |
T12394 |
det |
the,system |
R3344 |
T12394 |
T12383 |
dobj |
system,activates |
R3345 |
T12395 |
T12396 |
compound |
renin,angiotensin |
R3346 |
T12396 |
T12394 |
compound |
angiotensin,system |
R3347 |
T12397 |
T12396 |
punct |
-,angiotensin |
R3348 |
T12398 |
T12383 |
punct |
", ",activates |
R3349 |
T12399 |
T12383 |
advcl |
increasing,activates |
R3350 |
T12400 |
T12401 |
compound |
blood,pressure |
R3351 |
T12401 |
T12399 |
dobj |
pressure,increasing |
R3352 |
T12402 |
T12403 |
punct |
[,26 |
R3353 |
T12403 |
T12383 |
parataxis |
26,activates |
R3354 |
T12404 |
T12403 |
punct |
],26 |
R3355 |
T12405 |
T12383 |
punct |
.,activates |
R3356 |
T12407 |
T12408 |
nsubj |
Disruption,results |
R3357 |
T12409 |
T12407 |
prep |
of,Disruption |
R3358 |
T12410 |
T12411 |
det |
the,system |
R3359 |
T12411 |
T12409 |
pobj |
system,of |
R3360 |
T12412 |
T12413 |
compound |
renin,angiotensin |
R3361 |
T12413 |
T12411 |
compound |
angiotensin,system |
R3362 |
T12414 |
T12413 |
punct |
-,angiotensin |
R3363 |
T12415 |
T12407 |
prep |
during,Disruption |
R3364 |
T12416 |
T12415 |
pobj |
development,during |
R3365 |
T12417 |
T12408 |
prep |
in,results |
R3366 |
T12418 |
T12419 |
amod |
congenital,abnormalities |
R3367 |
T12419 |
T12417 |
pobj |
abnormalities,in |
R3368 |
T12420 |
T12419 |
prep |
of,abnormalities |
R3369 |
T12421 |
T12422 |
det |
the,ureter |
R3370 |
T12422 |
T12420 |
pobj |
ureter,of |
R3371 |
T12423 |
T12422 |
cc |
and,ureter |
R3372 |
T12424 |
T12425 |
compound |
collecting,duct |
R3373 |
T12425 |
T12427 |
compound |
duct,system |
R3374 |
T12426 |
T12425 |
punct |
-,duct |
R3375 |
T12427 |
T12422 |
conj |
system,ureter |
R3376 |
T12428 |
T12429 |
punct |
[,27 |
R3377 |
T12429 |
T12408 |
parataxis |
27,results |
R3378 |
T12430 |
T12429 |
punct |
],27 |
R3379 |
T12431 |
T12408 |
punct |
.,results |
R3380 |
T12433 |
T12434 |
nsubjpass |
Timeless,shown |
R3381 |
T12435 |
T12433 |
punct |
", ",Timeless |
R3382 |
T12436 |
T12437 |
det |
a,factor |
R3383 |
T12437 |
T12433 |
appos |
factor,Timeless |
R3384 |
T12438 |
T12437 |
compound |
transcription,factor |
R3385 |
T12439 |
T12437 |
acl |
involved,factor |
R3386 |
T12440 |
T12439 |
prep |
in,involved |
R3387 |
T12441 |
T12442 |
det |
the,regulation |
R3388 |
T12442 |
T12440 |
pobj |
regulation,in |
R3389 |
T12443 |
T12442 |
prep |
of,regulation |
R3390 |
T12444 |
T12445 |
amod |
circadian,rhythms |
R3391 |
T12445 |
T12443 |
pobj |
rhythms,of |
R3392 |
T12446 |
T12439 |
punct |
", ",involved |
R3393 |
T12447 |
T12439 |
cc |
and,involved |
R3394 |
T12448 |
T12439 |
conj |
expressed,involved |
R3395 |
T12449 |
T12448 |
prep |
in,expressed |
R3396 |
T12450 |
T12451 |
det |
the,tips |
R3397 |
T12451 |
T12449 |
pobj |
tips,in |
R3398 |
T12452 |
T12451 |
amod |
branching,tips |
R3399 |
T12453 |
T12451 |
amod |
ureteric,tips |
R3400 |
T12454 |
T12434 |
punct |
", ",shown |
R3401 |
T12455 |
T12434 |
aux |
has,shown |
R3402 |
T12456 |
T12434 |
advmod |
also,shown |
R3403 |
T12457 |
T12434 |
auxpass |
been,shown |
R3404 |
T12458 |
T12459 |
aux |
to,regulate |
R3405 |
T12459 |
T12434 |
xcomp |
regulate,shown |
R3406 |
T12460 |
T12461 |
amod |
ureteric,morphogenesis |
R3407 |
T12461 |
T12459 |
dobj |
morphogenesis,regulate |
R3408 |
T12462 |
T12461 |
compound |
branching,morphogenesis |
R3409 |
T12463 |
T12464 |
punct |
[,28 |
R3410 |
T12464 |
T12434 |
parataxis |
28,shown |
R3411 |
T12465 |
T12464 |
punct |
],28 |
R3412 |
T12466 |
T12434 |
punct |
.,shown |