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PMC:1858683 / 2460-3431 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T2638 0-3 NN denotes Wnt
T2639 4-13 NN denotes signaling
T2640 14-16 VBZ denotes is
T2641 17-19 IN denotes of
T2642 20-28 JJ denotes critical
T2643 29-39 NN denotes importance
T2644 40-42 IN denotes in
T2645 43-50 JJ denotes several
T2646 51-57 NNS denotes stages
T2647 58-60 IN denotes of
T2648 61-67 NN denotes kidney
T2649 68-79 NN denotes development
T2650 79-80 . denotes .
T2651 80-187 sentence denotes Mutual inductive interactions between the ureteric bud and metanephric mesenchyme drive nephrogenesis [1].
T2652 81-87 JJ denotes Mutual
T2653 98-110 NNS denotes interactions
T2654 88-97 JJ denotes inductive
T2655 163-168 VBP denotes drive
T2656 111-118 IN denotes between
T2657 119-122 DT denotes the
T2658 132-135 NN denotes bud
T2659 123-131 JJ denotes ureteric
T2660 136-139 CC denotes and
T2661 140-151 JJ denotes metanephric
T2662 152-162 NN denotes mesenchyme
T2663 169-182 NN denotes nephrogenesis
T2664 183-184 -LRB- denotes [
T2665 184-185 CD denotes 1
T2666 185-186 -RRB- denotes ]
T2667 186-187 . denotes .
T2668 187-296 sentence denotes The ureteric bud synthesizes Wnt9b, which is essential for induction of the mesenchyme to form nephrons [2].
T2669 188-191 DT denotes The
T2670 201-204 NN denotes bud
T2671 192-200 JJ denotes ureteric
T2672 205-216 VBZ denotes synthesizes
T2673 217-222 NN denotes Wnt9b
T2674 222-224 , denotes ,
T2675 224-229 WDT denotes which
T2676 230-232 VBZ denotes is
T2677 233-242 JJ denotes essential
T2678 243-246 IN denotes for
T2679 247-256 NN denotes induction
T2680 257-259 IN denotes of
T2681 260-263 DT denotes the
T2682 264-274 NN denotes mesenchyme
T2683 275-277 TO denotes to
T2684 278-282 VB denotes form
T2685 283-291 NNS denotes nephrons
T2686 292-293 -LRB- denotes [
T2687 293-294 CD denotes 2
T2688 294-295 -RRB- denotes ]
T2689 295-296 . denotes .
T2690 296-391 sentence denotes Wnt4 is made by the induced metanephric mesenchyme and is also required for nephrogenesis [3].
T2691 297-301 NN denotes Wnt4
T2692 305-309 VBN denotes made
T2693 302-304 VBZ denotes is
T2694 310-312 IN denotes by
T2695 313-316 DT denotes the
T2696 337-347 NN denotes mesenchyme
T2697 317-324 VBN denotes induced
T2698 325-336 JJ denotes metanephric
T2699 348-351 CC denotes and
T2700 352-354 VBZ denotes is
T2701 360-368 VBN denotes required
T2702 355-359 RB denotes also
T2703 369-372 IN denotes for
T2704 373-386 NN denotes nephrogenesis
T2705 387-388 -LRB- denotes [
T2706 388-389 CD denotes 3
T2707 389-390 -RRB- denotes ]
T2708 390-391 . denotes .
T2709 391-594 sentence denotes Furthermore, Wnt11, secreted by the ureteric bud tips, participates in a positive feedback loop promoting glial cell line-derived neurotrophic factor (GDNF) expression by the metanephric mesenchyme [4].
T2710 392-403 RB denotes Furthermore
T2711 447-459 VBZ denotes participates
T2712 403-405 , denotes ,
T2713 405-410 NN denotes Wnt11
T2714 410-412 , denotes ,
T2715 412-420 VBN denotes secreted
T2716 421-423 IN denotes by
T2717 424-427 DT denotes the
T2718 441-445 NNS denotes tips
T2719 428-436 JJ denotes ureteric
T2720 437-440 NN denotes bud
T2721 445-447 , denotes ,
T2722 460-462 IN denotes in
T2723 463-464 DT denotes a
T2724 483-487 NN denotes loop
T2725 465-473 JJ denotes positive
T2726 474-482 NN denotes feedback
T2727 488-497 VBG denotes promoting
T2728 498-503 JJ denotes glial
T2729 509-513 NN denotes line
T2730 504-508 NN denotes cell
T2731 514-521 VBN denotes derived
T2732 513-514 HYPH denotes -
T2733 535-541 NN denotes factor
T2734 522-534 JJ denotes neurotrophic
T2735 549-559 NN denotes expression
T2736 542-543 -LRB- denotes (
T2737 543-547 NN denotes GDNF
T2738 547-548 -RRB- denotes )
T2739 560-562 IN denotes by
T2740 563-566 DT denotes the
T2741 579-589 NN denotes mesenchyme
T2742 567-578 JJ denotes metanephric
T2743 590-591 -LRB- denotes [
T2744 591-592 CD denotes 4
T2745 592-593 -RRB- denotes ]
T2746 593-594 . denotes .
T2747 594-738 sentence denotes Mutations in Wnt9b or Wnt4 result in a dramatic block in nephron formation, while Wnt11 mutants show a significant reduction in nephron number.
T2748 595-604 NNS denotes Mutations
T2749 622-628 VBP denotes result
T2750 605-607 IN denotes in
T2751 608-613 NN denotes Wnt9b
T2752 614-616 CC denotes or
T2753 617-621 NN denotes Wnt4
T2754 629-631 IN denotes in
T2755 632-633 DT denotes a
T2756 643-648 NN denotes block
T2757 634-642 JJ denotes dramatic
T2758 649-651 IN denotes in
T2759 652-659 NN denotes nephron
T2760 660-669 NN denotes formation
T2761 669-671 , denotes ,
T2762 671-676 IN denotes while
T2763 691-695 VBP denotes show
T2764 677-682 NN denotes Wnt11
T2765 683-690 NNS denotes mutants
T2766 696-697 DT denotes a
T2767 710-719 NN denotes reduction
T2768 698-709 JJ denotes significant
T2769 720-722 IN denotes in
T2770 723-730 NN denotes nephron
T2771 731-737 NN denotes number
T2772 737-738 . denotes .
T2773 738-971 sentence denotes It is interesting to note that Wnt4 and Wnt11 have been shown to signal, at least in some cases, through noncanonical pathways [5-7], while there is evidence indicating that Wnt9b activates canonical Wnt signaling in the kidney [2].
T2774 739-741 PRP denotes It
T2775 742-744 VBZ denotes is
T2776 745-756 JJ denotes interesting
T2777 757-759 TO denotes to
T2778 760-764 VB denotes note
T2779 765-769 IN denotes that
T2780 795-800 VBN denotes shown
T2781 770-774 NN denotes Wnt4
T2782 775-778 CC denotes and
T2783 779-784 NN denotes Wnt11
T2784 785-789 VBP denotes have
T2785 790-794 VBN denotes been
T2786 801-803 TO denotes to
T2787 804-810 VB denotes signal
T2788 810-812 , denotes ,
T2789 812-814 RB denotes at
T2790 815-820 RBS denotes least
T2791 821-823 IN denotes in
T2792 824-828 DT denotes some
T2793 829-834 NNS denotes cases
T2794 834-836 , denotes ,
T2795 836-843 IN denotes through
T2796 844-856 JJ denotes noncanonical
T2797 857-865 NNS denotes pathways
T2798 866-867 -LRB- denotes [
T2799 867-868 CD denotes 5
T2800 868-869 SYM denotes -
T2801 869-870 CD denotes 7
T2802 870-871 -RRB- denotes ]
T2803 871-873 , denotes ,
T2804 873-878 IN denotes while
T2805 885-887 VBZ denotes is
T2806 879-884 EX denotes there
T2807 888-896 NN denotes evidence
T2808 897-907 VBG denotes indicating
T2809 908-912 IN denotes that
T2810 919-928 VBZ denotes activates
T2811 913-918 NN denotes Wnt9b
T2812 929-938 JJ denotes canonical
T2813 943-952 NN denotes signaling
T2814 939-942 NN denotes Wnt
T2815 953-955 IN denotes in
T2816 956-959 DT denotes the
T2817 960-966 NN denotes kidney
T2818 967-968 -LRB- denotes [
T2819 968-969 CD denotes 2
T2820 969-970 -RRB- denotes ]
T2821 970-971 . denotes .
R398 T2638 T2639 compound Wnt,signaling
R399 T2639 T2640 nsubj signaling,is
R400 T2641 T2640 prep of,is
R401 T2642 T2643 amod critical,importance
R402 T2643 T2641 pobj importance,of
R403 T2644 T2640 prep in,is
R404 T2645 T2646 amod several,stages
R405 T2646 T2644 pobj stages,in
R406 T2647 T2646 prep of,stages
R407 T2648 T2649 compound kidney,development
R408 T2649 T2647 pobj development,of
R409 T2650 T2640 punct .,is
R410 T2652 T2653 amod Mutual,interactions
R411 T2653 T2655 nsubj interactions,drive
R412 T2654 T2653 amod inductive,interactions
R413 T2656 T2653 prep between,interactions
R414 T2657 T2658 det the,bud
R415 T2658 T2656 pobj bud,between
R416 T2659 T2658 amod ureteric,bud
R417 T2660 T2658 cc and,bud
R418 T2661 T2662 amod metanephric,mesenchyme
R419 T2662 T2658 conj mesenchyme,bud
R420 T2663 T2655 dobj nephrogenesis,drive
R421 T2664 T2665 punct [,1
R422 T2665 T2655 parataxis 1,drive
R423 T2666 T2665 punct ],1
R424 T2667 T2655 punct .,drive
R425 T2669 T2670 det The,bud
R426 T2670 T2672 nsubj bud,synthesizes
R427 T2671 T2670 amod ureteric,bud
R428 T2673 T2672 dobj Wnt9b,synthesizes
R429 T2674 T2673 punct ", ",Wnt9b
R430 T2675 T2676 dep which,is
R431 T2676 T2673 relcl is,Wnt9b
R432 T2677 T2676 acomp essential,is
R433 T2678 T2677 prep for,essential
R434 T2679 T2678 pobj induction,for
R435 T2680 T2679 prep of,induction
R436 T2681 T2682 det the,mesenchyme
R437 T2682 T2680 pobj mesenchyme,of
R438 T2683 T2684 aux to,form
R439 T2684 T2679 acl form,induction
R440 T2685 T2684 dobj nephrons,form
R441 T2686 T2687 punct [,2
R442 T2687 T2672 parataxis 2,synthesizes
R443 T2688 T2687 punct ],2
R444 T2689 T2672 punct .,synthesizes
R445 T2691 T2692 nsubjpass Wnt4,made
R446 T2693 T2692 auxpass is,made
R447 T2694 T2692 agent by,made
R448 T2695 T2696 det the,mesenchyme
R449 T2696 T2694 pobj mesenchyme,by
R450 T2697 T2696 amod induced,mesenchyme
R451 T2698 T2696 amod metanephric,mesenchyme
R452 T2699 T2692 cc and,made
R453 T2700 T2701 auxpass is,required
R454 T2701 T2692 conj required,made
R455 T2702 T2701 advmod also,required
R456 T2703 T2701 prep for,required
R457 T2704 T2703 pobj nephrogenesis,for
R458 T2705 T2706 punct [,3
R459 T2706 T2701 parataxis 3,required
R460 T2707 T2706 punct ],3
R461 T2708 T2692 punct .,made
R462 T2710 T2711 advmod Furthermore,participates
R463 T2712 T2711 punct ", ",participates
R464 T2713 T2711 nsubj Wnt11,participates
R465 T2714 T2713 punct ", ",Wnt11
R466 T2715 T2713 acl secreted,Wnt11
R467 T2716 T2715 agent by,secreted
R468 T2717 T2718 det the,tips
R469 T2718 T2716 pobj tips,by
R470 T2719 T2720 amod ureteric,bud
R471 T2720 T2718 compound bud,tips
R472 T2721 T2711 punct ", ",participates
R473 T2722 T2711 prep in,participates
R474 T2723 T2724 det a,loop
R475 T2724 T2722 pobj loop,in
R476 T2725 T2724 amod positive,loop
R477 T2726 T2724 compound feedback,loop
R478 T2727 T2724 acl promoting,loop
R479 T2728 T2729 amod glial,line
R480 T2729 T2731 npadvmod line,derived
R481 T2730 T2729 compound cell,line
R482 T2731 T2733 amod derived,factor
R483 T2732 T2731 punct -,derived
R484 T2733 T2735 nmod factor,expression
R485 T2734 T2733 amod neurotrophic,factor
R486 T2735 T2727 dobj expression,promoting
R487 T2736 T2733 punct (,factor
R488 T2737 T2733 appos GDNF,factor
R489 T2738 T2735 punct ),expression
R490 T2739 T2735 prep by,expression
R491 T2740 T2741 det the,mesenchyme
R492 T2741 T2739 pobj mesenchyme,by
R493 T2742 T2741 amod metanephric,mesenchyme
R494 T2743 T2744 punct [,4
R495 T2744 T2711 parataxis 4,participates
R496 T2745 T2744 punct ],4
R497 T2746 T2711 punct .,participates
R498 T2748 T2749 nsubj Mutations,result
R499 T2750 T2748 prep in,Mutations
R500 T2751 T2750 pobj Wnt9b,in
R501 T2752 T2751 cc or,Wnt9b
R502 T2753 T2751 conj Wnt4,Wnt9b
R503 T2754 T2749 prep in,result
R504 T2755 T2756 det a,block
R505 T2756 T2754 pobj block,in
R506 T2757 T2756 amod dramatic,block
R507 T2758 T2756 prep in,block
R508 T2759 T2760 compound nephron,formation
R509 T2760 T2758 pobj formation,in
R510 T2761 T2749 punct ", ",result
R511 T2762 T2763 mark while,show
R512 T2763 T2749 advcl show,result
R513 T2764 T2765 compound Wnt11,mutants
R514 T2765 T2763 nsubj mutants,show
R515 T2766 T2767 det a,reduction
R516 T2767 T2763 dobj reduction,show
R517 T2768 T2767 amod significant,reduction
R518 T2769 T2767 prep in,reduction
R519 T2770 T2771 compound nephron,number
R520 T2771 T2769 pobj number,in
R521 T2772 T2749 punct .,result
R522 T2774 T2775 nsubj It,is
R523 T2776 T2775 acomp interesting,is
R524 T2777 T2778 aux to,note
R525 T2778 T2775 xcomp note,is
R526 T2779 T2780 mark that,shown
R527 T2780 T2778 ccomp shown,note
R528 T2781 T2780 nsubjpass Wnt4,shown
R529 T2782 T2781 cc and,Wnt4
R530 T2783 T2781 conj Wnt11,Wnt4
R531 T2784 T2780 aux have,shown
R532 T2785 T2780 auxpass been,shown
R533 T2786 T2787 aux to,signal
R534 T2787 T2780 xcomp signal,shown
R535 T2788 T2787 punct ", ",signal
R536 T2789 T2790 advmod at,least
R537 T2790 T2791 advmod least,in
R538 T2791 T2787 prep in,signal
R539 T2792 T2793 det some,cases
R540 T2793 T2791 pobj cases,in
R541 T2794 T2787 punct ", ",signal
R542 T2795 T2787 prep through,signal
R543 T2796 T2797 amod noncanonical,pathways
R544 T2797 T2795 pobj pathways,through
R545 T2798 T2799 punct [,5
R546 T2799 T2787 parataxis 5,signal
R547 T2800 T2801 punct -,7
R548 T2801 T2799 prep 7,5
R549 T2802 T2799 punct ],5
R550 T2803 T2778 punct ", ",note
R551 T2804 T2805 mark while,is
R552 T2805 T2778 advcl is,note
R553 T2806 T2805 expl there,is
R554 T2807 T2805 attr evidence,is
R555 T2808 T2807 acl indicating,evidence
R556 T2809 T2810 mark that,activates
R557 T2810 T2808 ccomp activates,indicating
R558 T2811 T2810 nsubj Wnt9b,activates
R559 T2812 T2813 amod canonical,signaling
R560 T2813 T2810 dobj signaling,activates
R561 T2814 T2813 compound Wnt,signaling
R562 T2815 T2810 prep in,activates
R563 T2816 T2817 det the,kidney
R564 T2817 T2815 pobj kidney,in
R565 T2818 T2819 punct [,2
R566 T2819 T2810 parataxis 2,activates
R567 T2820 T2819 punct ],2
R568 T2821 T2775 punct .,is

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T2522 0-13 GO:0016055 denotes Wnt signaling
T2523 61-67 UBERON:0002113 denotes kidney
T2524 61-79 GO:0001822 denotes kidney development
T2525 123-135 UBERON:0000084 denotes ureteric bud
T2526 140-162 UBERON:0003220 denotes metanephric mesenchyme
T2527 169-182 GO:0001822 denotes nephrogenesis
T2528 192-204 UBERON:0000084 denotes ureteric bud
T2529 217-222 PR_EXT:000017453 denotes Wnt9b
T2530 264-274 UBERON:0003104 denotes mesenchyme
T2531 283-291 UBERON:0001285 denotes nephrons
T2532 297-301 PR_EXT:000017444 denotes Wnt4
T2533 325-347 UBERON:0003220 denotes metanephric mesenchyme
T2534 373-386 GO:0001822 denotes nephrogenesis
T2535 405-410 PR_EXT:000017438 denotes Wnt11
T2536 412-420 GO:0046903 denotes secreted
T2537 428-445 UBERON:0006364 denotes ureteric bud tips
T2538 498-508 CL:0000125 denotes glial cell
T2539 498-541 PR_EXT:000007928 denotes glial cell line-derived neurotrophic factor
T2540 504-508 CL_GO_EXT:cell denotes cell
T2541 522-534 GO_EXT:neuron_development_or_generation denotes neurotrophic
T2542 543-547 PR_EXT:000007928 denotes GDNF
T2543 549-559 GO:0010467 denotes expression
T2544 567-589 UBERON:0003220 denotes metanephric mesenchyme
T2545 595-604 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T2546 608-613 PR_EXT:000017453 denotes Wnt9b
T2547 617-621 PR_EXT:000017444 denotes Wnt4
T2548 652-659 UBERON:0001285 denotes nephron
T2549 652-669 GO:0072006 denotes nephron formation
T2550 677-682 PR_EXT:000017438 denotes Wnt11
T2551 683-690 SO_EXT:sequence_altered_entity denotes mutants
T2552 723-730 UBERON:0001285 denotes nephron
T2553 770-774 PR_EXT:000017444 denotes Wnt4
T2554 779-784 PR_EXT:000017438 denotes Wnt11
T2555 804-810 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signal
T2556 913-918 PR_EXT:000017453 denotes Wnt9b
T2557 929-952 GO:0060070 denotes canonical Wnt signaling
T2558 960-966 UBERON:0002113 denotes kidney

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T2429 0-13 GO:0016055 denotes Wnt signaling
T2430 61-67 UBERON:0002113 denotes kidney
T2431 61-79 GO:0001822 denotes kidney development
T2432 123-135 UBERON:0000084 denotes ureteric bud
T2433 140-162 UBERON:0003220 denotes metanephric mesenchyme
T2434 169-182 GO:0001822 denotes nephrogenesis
T2435 192-204 UBERON:0000084 denotes ureteric bud
T2436 217-222 PR:000017453 denotes Wnt9b
T2437 264-274 UBERON:0003104 denotes mesenchyme
T2438 283-291 UBERON:0001285 denotes nephrons
T2439 297-301 PR:000017444 denotes Wnt4
T2440 325-347 UBERON:0003220 denotes metanephric mesenchyme
T2441 373-386 GO:0001822 denotes nephrogenesis
T2442 405-410 PR:000017438 denotes Wnt11
T2443 412-420 GO:0046903 denotes secreted
T2444 428-445 UBERON:0006364 denotes ureteric bud tips
T2445 498-508 CL:0000125 denotes glial cell
T2446 498-541 PR:000007928 denotes glial cell line-derived neurotrophic factor
T2447 543-547 PR:000007928 denotes GDNF
T2448 549-559 GO:0010467 denotes expression
T2449 567-589 UBERON:0003220 denotes metanephric mesenchyme
T2450 608-613 PR:000017453 denotes Wnt9b
T2451 617-621 PR:000017444 denotes Wnt4
T2452 652-659 UBERON:0001285 denotes nephron
T2453 652-669 GO:0072006 denotes nephron formation
T2454 677-682 PR:000017438 denotes Wnt11
T2455 723-730 UBERON:0001285 denotes nephron
T2456 770-774 PR:000017444 denotes Wnt4
T2457 779-784 PR:000017438 denotes Wnt11
T2458 913-918 PR:000017453 denotes Wnt9b
T2459 929-952 GO:0060070 denotes canonical Wnt signaling
T2460 960-966 UBERON:0002113 denotes kidney

2_test

Id Subject Object Predicate Lexical cue
17425782-3153305-8469427 184-185 3153305 denotes 1
17425782-16054034-8469428 293-294 16054034 denotes 2
17425782-7990960-8469429 388-389 7990960 denotes 3
17425782-12783789-8469430 591-592 12783789 denotes 4
17425782-7739543-8469431 867-868 7739543 denotes 5
17425782-15775981-8469431 867-868 15775981 denotes 5
17425782-12167861-8469431 867-868 12167861 denotes 5
17425782-16054034-8469432 968-969 16054034 denotes 2