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Id Subject Object Predicate Lexical cue
T27371 5407-5418 VB denotes demonstrate
T27370 5404-5406 TO denotes to
T27369 5390-5394 VBD denotes were
T27368 5395-5403 VBN denotes included
T27367 5377-5382 NN denotes Pygo2
T27366 5373-5376 CC denotes and
T27365 5383-5389 NNS denotes probes
T27364 5367-5372 NN denotes Pygo1
T27363 5366-5460 sentence denotes Pygo1 and Pygo2 probes were included to demonstrate significant changes in expression levels.
T27362 5365-5366 . denotes .
T27361 5358-5365 NNS denotes samples
T27360 5350-5355 RBS denotes least
T27359 5356-5357 CD denotes 3
T27358 5347-5349 RB denotes at
T27357 5344-5346 IN denotes in
T27356 5340-5343 CD denotes 100
T27355 5339-5340 SYM denotes >
T27354 5336-5338 VB denotes be
T27353 5333-5335 TO denotes to
T27352 5312-5322 NN denotes expression
T27351 5308-5311 JJ denotes raw
T27350 5323-5332 NN denotes intensity
T27349 5304-5307 DT denotes the
T27348 5294-5303 VBG denotes requiring
T27347 5276-5281 NN denotes level
T27346 5265-5275 NN denotes expression
T27345 5282-5293 NN denotes restriction
T27344 5262-5264 DT denotes an
T27343 5256-5261 VBG denotes using
T27342 5250-5255 NNS denotes genes
T27341 5247-5249 CD denotes 40
T27340 5244-5246 IN denotes of
T27339 5238-5243 NN denotes total
T27338 5236-5237 DT denotes a
T27337 5233-5235 IN denotes to
T27336 5225-5232 VBN denotes reduced
T27335 5220-5224 RB denotes then
T27334 5216-5219 CC denotes and
T27333 5204-5207 VBD denotes was
T27332 5192-5195 NN denotes Wnt
T27331 5196-5203 NNS denotes targets
T27330 5189-5191 CD denotes 82
T27329 5186-5188 IN denotes of
T27328 5208-5215 VBN denotes created
T27327 5176-5180 NN denotes gene
T27326 5168-5175 JJ denotes initial
T27325 5181-5185 NN denotes list
T27324 5165-5167 DT denotes An
T27323 5164-5366 sentence denotes An initial gene list of 82 Wnt targets was created and then reduced to a total of 40 genes using an expression level restriction requiring the raw expression intensity to be >100 in at least 3 samples.
T27322 5163-5164 . denotes .
T27321 5162-5163 -RRB- denotes ]
T27320 5160-5162 CD denotes 39
T27319 5159-5160 -LRB- denotes [
T27318 5156-5158 IN denotes at
T27317 5147-5155 VBN denotes compiled
T27316 5141-5146 DT denotes those
T27589 1444-1449 NN denotes Pygo2
T27588 1438-1443 NN denotes Pygo1
T27587 1461-1467 NN denotes kidney
T27586 1434-1437 DT denotes the
T27585 1431-1433 IN denotes in
T27584 1429-1430 -RRB- denotes )
T27583 1422-1429 JJR denotes greater
T27582 1419-1421 CC denotes or
T27581 1403-1411 JJ denotes two-fold
T27580 1401-1403 , denotes ,
T27579 1395-1396 SYM denotes <
T27578 1397-1401 CD denotes 0.05
T27577 1393-1394 NN denotes p
T27576 1412-1418 NN denotes change
T27575 1392-1393 -LRB- denotes (
T27574 1382-1391 VBN denotes expressed
T27573 1367-1381 RB denotes differentially
T27572 1361-1366 NNS denotes Genes
T27310 5101-5109 JJ denotes Possible
T27309 5100-5164 sentence denotes Possible Wnt targets were selected from those compiled at [39].
T27308 5099-5100 . denotes .
T27307 5086-5091 NN denotes E18.5
T27306 5072-5080 NN denotes compound
T27305 5070-5071 CD denotes 2
T27304 5069-5070 HYPH denotes /
T27303 5081-5085 JJ denotes null
T27302 5064-5069 NN denotes Pygo1
T27301 5060-5063 CC denotes and
T27300 5092-5099 NNS denotes kidneys
T27299 5054-5055 HYPH denotes -
T27298 5055-5059 NN denotes type
T27297 5050-5054 JJ denotes wild
T27296 5047-5049 IN denotes on
T27295 5036-5046 NN denotes triplicate
T27294 5033-5035 IN denotes in
T27293 5019-5022 VBD denotes was
T27292 5023-5032 VBN denotes performed
T27291 5010-5018 NN denotes analysis
T27290 4999-5009 NN denotes Microarray
T27289 4998-5100 sentence denotes Microarray analysis was performed in triplicate on wild-type and Pygo1/2 compound null E18.5 kidneys.
T27288 4997-4998 . denotes .
T27287 4986-4990 JJ denotes null
T27286 4979-4980 HYPH denotes /
T27285 4980-4985 NN denotes Pygo2
T27284 4974-4979 NN denotes Pygo1
T27283 4968-4973 NN denotes E18.5
T27282 4991-4997 NN denotes kidney
T27281 4964-4967 DT denotes the
T27280 4961-4963 IN denotes in
T27279 4943-4952 NN denotes signaling
T27278 4939-4942 NN denotes Wnt
T27277 4953-4960 NNS denotes targets
T27276 4932-4938 JJ denotes common
T27275 4929-4931 IN denotes of
T27274 4921-4928 NNS denotes changes
T27273 4910-4920 NN denotes expression
T27272 4905-4909 NN denotes Gene
T12571 4673-4677 IN denotes with
T12570 4671-4673 , denotes ,
T12569 4650-4663 RB denotes significantly
T12568 4645-4649 VBD denotes were
T12567 4643-4644 -RRB- denotes ]
T12566 4641-4643 CD denotes 30
T12565 4640-4641 -LRB- denotes [
T12564 4634-4639 NN denotes Wisp1
T12563 4630-4633 CC denotes and
T12562 4628-4630 , denotes ,
T12561 4627-4628 -RRB- denotes ]
T12560 4625-4627 CD denotes 29
T12559 4624-4625 -LRB- denotes [
T12558 4614-4620 NN denotes cyclin
T12557 4621-4623 NN denotes D1
T12556 4605-4613 VBG denotes encoding
T12555 4599-4604 NN denotes Ccnd1
T12554 4596-4598 IN denotes of
T12553 4664-4671 VBN denotes changed
T12552 4581-4584 DT denotes the
T12551 4585-4595 NN denotes expression
T12550 4576-4580 RB denotes Only
T12549 4575-4744 sentence denotes Only the expression of Ccnd1 encoding cyclin D1 [29], and Wisp1 [30] were significantly changed, with expression level changes of <1.5-fold in Pygo1/Pygo2 null kidneys.
T12548 4574-4575 . denotes .
T12547 4573-4574 -RRB- denotes )
T12546 4572-4573 CD denotes 8
T12545 4565-4571 NN denotes Figure
T12544 4564-4565 -LRB- denotes (
T12543 4549-4555 NN denotes mutant
T12542 4545-4548 CC denotes and
T12541 4556-4563 NNS denotes kidneys
T12540 4539-4540 HYPH denotes -
T12539 4540-4544 NN denotes type
T12538 4535-4539 JJ denotes wild
T12537 4527-4534 IN denotes between
T12536 4516-4526 NN denotes expression
T12535 4513-4515 IN denotes in
T12534 4501-4512 NNS denotes differences
T12533 4497-4500 JJ denotes few
T12532 4492-4496 RB denotes very
T12531 4472-4478 NN denotes target
T12530 4468-4471 NN denotes Wnt
T12529 4462-4467 VBN denotes known
T12528 4479-4484 NNS denotes genes
T12527 4458-4461 DT denotes the
T12526 4456-4458 , denotes ,
T12525 4485-4491 VBD denotes showed
T12524 4446-4456 RB denotes Remarkably
T12523 4445-4575 sentence denotes Remarkably, the known Wnt target genes showed very few differences in expression between wild-type and mutant kidneys (Figure 8).
T12522 4444-4445 . denotes .
T12521 4429-4433 JJ denotes down
T12520 4434-4444 NN denotes regulation
T12519 4417-4428 JJ denotes significant
T12518 4406-4416 VB denotes illustrate
T12517 4403-4405 TO denotes to
T12516 4392-4402 NNS denotes references
T12515 4389-4391 IN denotes as
T12514 4375-4379 VBD denotes were
T12513 4380-4388 VBN denotes included
T12512 4364-4369 NN denotes probe
T12511 4358-4363 NN denotes Pygo2
T12510 4354-4357 CC denotes and
T12509 4370-4374 NNS denotes sets
T12508 4348-4353 NN denotes Pygo1
T12507 4343-4347 CC denotes Both
T12506 4342-4445 sentence denotes Both Pygo1 and Pygo2 probe sets were included as references to illustrate significant down regulation.
T12505 4341-4342 . denotes .
T12504 4336-4340 IN denotes from
T12503 4323-4326 VBD denotes was
T12502 4311-4314 NN denotes Wnt
T12501 4315-4322 NNS denotes targets
T12500 4305-4310 JJ denotes known
T12499 4302-4304 IN denotes of
T12498 4327-4335 VBN denotes compiled
T12497 4297-4301 NN denotes list
T12496 4295-4296 DT denotes A
T12495 4294-4342 sentence denotes A list of known Wnt targets was compiled from .
T12494 4293-4294 . denotes .
T12493 4277-4278 SYM denotes -
T12492 4276-4277 HYPH denotes /
T12491 4275-4276 SYM denotes -
T12490 4270-4275 NN denotes Pygo2
T12489 4269-4270 HYPH denotes /
T12488 4268-4269 SYM denotes -
T12487 4267-4268 HYPH denotes /
T12486 4266-4267 SYM denotes -
T12485 4279-4285 NN denotes mutant
T12484 4261-4266 NN denotes Pygo1
T12483 4286-4293 NNS denotes kidneys
T12482 4257-4260 DT denotes the
T12481 4254-4256 IN denotes in
T12480 4242-4245 NN denotes Wnt
T12479 4246-4253 NNS denotes targets
T12478 4236-4241 VBN denotes known
T12477 4225-4235 RB denotes previously
T12476 4222-4224 IN denotes of
T12475 4203-4210 VBN denotes altered
T12474 4194-4202 JJ denotes possible
T12473 4211-4221 NN denotes expression
T12472 4190-4193 DT denotes the
T12471 4187-4189 IN denotes in
T12470 4176-4186 JJ denotes interested
T12469 4171-4175 VBD denotes were
T12468 4168-4170 PRP denotes We
T12467 4167-4294 sentence denotes We were interested in the possible altered expression of previously known Wnt targets in the Pygo1-/-/Pygo2-/- mutant kidneys.
T12466 4166-4167 . denotes .
T12465 4165-4166 -RRB- denotes ]
T12464 4163-4165 CD denotes 28
T12463 4162-4163 -LRB- denotes [
T12462 4138-4147 NN denotes branching
T12461 4148-4161 NN denotes morphogenesis
T12460 4129-4137 JJ denotes ureteric
T12459 4120-4128 VB denotes regulate
T12458 4117-4119 TO denotes to
T12457 4106-4110 VBN denotes been
T12456 4101-4105 RB denotes also
T12455 4097-4100 VBZ denotes has
T12454 4095-4097 , denotes ,
T12453 4082-4090 JJ denotes ureteric
T12452 4072-4081 VBG denotes branching
T12451 4091-4095 NNS denotes tips
T12450 4068-4071 DT denotes the
T12449 4065-4067 IN denotes in
T12448 4055-4064 VBN denotes expressed
T12447 4051-4054 CC denotes and
T12446 4049-4051 , denotes ,
T12445 4042-4049 NNS denotes rhythms
T12444 4032-4041 JJ denotes circadian
T12443 4029-4031 IN denotes of
T12442 4018-4028 NN denotes regulation
T12441 4014-4017 DT denotes the
T12440 4011-4013 IN denotes in
T12439 4002-4010 VBN denotes involved
T12438 3981-3994 NN denotes transcription
T12437 3995-4001 NN denotes factor
T12436 3979-3980 DT denotes a
T12435 3977-3979 , denotes ,
T12434 4111-4116 VBN denotes shown
T12398 3790-3792 , denotes ,
T12397 3771-3772 HYPH denotes -
T12396 3772-3783 NN denotes angiotensin
T12395 3766-3771 NN denotes renin
T12394 3784-3790 NN denotes system
T12393 3762-3765 DT denotes the
T12392 3750-3752 , denotes ,
T12391 3749-3750 CD denotes 1
T12390 3743-3748 NN denotes Renin
T12389 3729-3742 NN denotes endopeptidase
T12388 3725-3728 DT denotes the
T12387 3722-3724 IN denotes of
T12386 3714-3721 NN denotes homolog
T12385 3712-3713 DT denotes a
T12384 3710-3712 , denotes ,
T12383 3752-3761 VBZ denotes activates
T12382 3706-3710 NN denotes Ren2
T12381 3705-3823 sentence denotes Ren2, a homolog of the endopeptidase Renin 1, activates the renin-angiotensin system, increasing blood pressure [26].
T12380 3704-3705 . denotes .
T12379 3703-3704 -RRB- denotes ]
T12378 3701-3703 CD denotes 25
T12377 3700-3701 -LRB- denotes [
T12376 3691-3699 NN denotes pressure
T12375 3685-3690 NN denotes blood
T12374 3682-3684 IN denotes of
T12373 3671-3681 NN denotes regulation
T12372 3667-3670 CC denotes and
T12371 3665-3667 , denotes ,
T12370 3655-3665 NN denotes remodeling
T12369 3648-3654 NN denotes tissue
T12368 3646-3648 , denotes ,
T12367 3640-3646 NN denotes cancer
T12366 3637-3639 IN denotes in
T12365 3627-3636 NNS denotes functions
T12364 3619-3626 JJ denotes diverse
T12363 3614-3618 VBP denotes have
T12361 3601-3705 sentence denotes Kallikreins have diverse functions in cancer, tissue remodeling, and regulation of blood pressure [25].
T12688 5869-5870 . denotes .
T12687 5854-5864 NN denotes microarray
T12686 5865-5869 NNS denotes data
T12685 5850-5853 DT denotes the
T12684 5840-5849 VBG denotes screening
T12683 5837-5839 IN denotes in
T12682 5832-5836 VBN denotes used
T12681 5817-5820 JJ denotes low
T12680 5806-5816 RB denotes relatively
T12679 5821-5831 NN denotes stringency
T12678 5802-5805 DT denotes the
T12677 5790-5801 VBG denotes considering
T12676 5788-5790 , denotes ,
T12675 5776-5778 VB denotes be
T12674 5772-5775 RB denotes not
T12673 5766-5771 MD denotes could
T12672 5755-5759 CD denotes nine
T12671 5760-5765 NNS denotes genes
T12670 5751-5754 DT denotes the
T12669 5748-5750 IN denotes of
T12668 5744-5747 CD denotes two
T12667 5779-5788 VBN denotes validated
T12666 5739-5743 IN denotes that
T12665 5728-5738 JJ denotes surprising
T12664 5724-5727 RB denotes not
T12663 5721-5723 VBZ denotes is
T12662 5718-5720 PRP denotes It
T12661 5717-5870 sentence denotes It is not surprising that two of the nine genes could not be validated, considering the relatively low stringency used in screening the microarray data.
T12660 5716-5717 . denotes .
T12659 5715-5716 -RRB- denotes )
T12658 5714-5715 CD denotes 4
T12657 5708-5713 NN denotes Table
T12656 5707-5708 -LRB- denotes (
T12655 5688-5698 NN denotes microarray
T12654 5699-5706 NNS denotes results
T12653 5684-5687 DT denotes the
T12652 5681-5683 IN denotes by
T12360 3600-3601 . denotes .
T12359 3584-3590 NN denotes serine
T12358 3591-3600 NNS denotes proteases
T12357 3578-3579 HYPH denotes -
T12356 3579-3583 JJ denotes like
T12355 3571-3578 NN denotes trypsin
T12354 3568-3570 IN denotes of
T12353 3550-3560 NN denotes kallikrein
T12352 3561-3567 NN denotes family
T12351 3546-3549 DT denotes the
T12350 3543-3545 IN denotes of
T12349 3535-3542 NNS denotes members
T12348 3526-3530 NN denotes Klk6
T12347 3522-3525 CC denotes and
T12346 3531-3534 VBP denotes are
T12345 3517-3521 NN denotes Klk5
T12344 3516-3601 sentence denotes Klk5 and Klk6 are members of the kallikrein family of trypsin-like serine proteases.
T12343 3515-3516 . denotes .
T12342 3514-3515 -RRB- denotes )
T12341 3506-3514 RB denotes 2.4-fold
T12340 3505-3506 -LRB- denotes (
T12339 3496-3504 NNP denotes Timeless
T12338 3492-3495 CC denotes and
T12337 3490-3492 , denotes ,
T12336 3489-3490 -RRB- denotes )
T12335 3481-3489 RB denotes 2.2-fold
T12334 3480-3481 -LRB- denotes (
T12333 3475-3479 NN denotes Ren2
T12332 3473-3475 , denotes ,
T12331 3472-3473 -RRB- denotes )
T12330 3464-3472 RB denotes 2.7-fold
T12329 3463-3464 -LRB- denotes (
T12328 3458-3462 NN denotes Klk6
T12327 3456-3458 , denotes ,
T12326 3455-3456 -RRB- denotes )
T12325 3447-3455 RB denotes 2.8-fold
T12324 3446-3447 -LRB- denotes (
T12323 3441-3445 NN denotes Klk5
T12322 3420-3424 JJ denotes null
T12321 3413-3414 HYPH denotes /
T12320 3414-3419 NN denotes Pygo2
T12319 3408-3413 NN denotes Pygo1
T12318 3425-3431 NN denotes kidney
T12317 3404-3407 DT denotes the
T12287 1235-1236 -RRB- denotes ]
T12286 1233-1235 CD denotes 24
T12285 1232-1233 -LRB- denotes [
T12284 1219-1224 JJ denotes adult
T12283 1225-1231 NN denotes kidney
T12282 1215-1218 DT denotes the
T12281 1212-1214 IN denotes of
T12280 1204-1211 NNS denotes tubules
T12279 1200-1203 DT denotes the
T12278 1197-1199 IN denotes in
T12277 1178-1186 RB denotes strongly
T12276 1173-1177 RB denotes also
T12275 1170-1172 VBZ denotes is
T12274 1168-1170 , denotes ,
T12273 1161-1168 NN denotes Slco1a4
T12272 1159-1161 , denotes ,
T12271 1187-1196 VBN denotes expressed
T12270 1142-1147 NN denotes anion
T12269 1134-1141 JJ denotes organic
T12268 1148-1159 NN denotes transporter
T12267 1130-1133 DT denotes The
T12266 1129-1237 sentence denotes The organic anion transporter, Slco1a4, is also strongly expressed in the tubules of the adult kidney [24].
T12265 1128-1129 . denotes .
T12264 1127-1128 -RRB- denotes ]
T12263 1125-1127 CD denotes 23
T12262 1124-1125 -LRB- denotes [
T12261 1116-1123 NN denotes nephron
T12260 1112-1115 DT denotes the
T12259 1109-1111 IN denotes by
T12258 1102-1108 NN denotes uptake
T12257 1094-1101 NN denotes glucose
T12256 1091-1093 IN denotes of
T12255 1086-1090 NN denotes loss
T12254 1083-1085 IN denotes by
T12253 1069-1082 VBN denotes characterized
T12252 1067-1069 , denotes ,
T12251 1051-1056 JJ denotes renal
T12250 1057-1067 NN denotes glucosuria
T12249 1041-1050 JJ denotes recessive
T12248 1031-1040 JJ denotes autosomal
T12247 1028-1030 IN denotes in
T12246 1012-1016 VBN denotes been
T12245 1017-1027 VBN denotes implicated
T12244 1008-1011 VBZ denotes has
T12243 1004-1007 CC denotes and
T12242 990-995 JJ denotes adult
T12241 996-1003 NN denotes nephron
T12240 986-989 DT denotes the
T12239 983-985 IN denotes of
T12238 966-974 JJ denotes proximal
T12237 975-982 NNS denotes tubules
T12236 962-965 DT denotes the
T12235 959-961 IN denotes in
T12234 946-948 VBZ denotes is
T12233 949-958 VBN denotes expressed
T12232 939-945 NN denotes Slc5a2
T12231 938-1129 sentence denotes Slc5a2 is expressed in the proximal tubules of the adult nephron and has been implicated in autosomal recessive renal glucosuria, characterized by loss of glucose uptake by the nephron [23].
T12230 937-938 . denotes .
T12229 936-937 -RRB- denotes )
T12228 926-927 SYM denotes -
T12227 928-936 RB denotes 2.1-fold
T12226 925-926 -LRB- denotes (
T12225 917-924 NN denotes Slco1a4
T12224 913-916 CC denotes and
T12223 911-913 , denotes ,
T12222 910-911 -RRB- denotes )
T12221 900-901 SYM denotes -
T12220 902-910 RB denotes 2.8-fold
T12219 899-900 -LRB- denotes (
T12218 892-898 NN denotes Slc5a2
T12217 890-892 , denotes ,
T12216 889-890 -RRB- denotes )
T12214 881-889 RB denotes 2.3-fold
T12213 878-879 -LRB- denotes (
T12212 871-877 NN denotes Cxcl13
T12211 854-861 NNS denotes kidneys
T12210 847-853 NN denotes mutant
T12209 844-846 IN denotes in
T12208 834-843 NNS denotes decreases
T12207 822-833 JJ denotes significant
T12206 817-821 IN denotes with
T12205 862-870 VBD denotes included
T12204 811-816 NNS denotes genes
T12203 805-810 JJ denotes Other
T12202 804-938 sentence denotes Other genes with significant decreases in mutant kidneys included Cxcl13 (- 2.3-fold), Slc5a2 (- 2.8-fold), and Slco1a4 (- 2.1-fold).
T12201 803-804 . denotes .
T12200 789-795 NN denotes mutant
T12199 796-803 NNS denotes kidneys
T12198 785-788 DT denotes the
T12197 782-784 IN denotes in
T12196 780-781 -RRB- denotes )
T12195 766-768 , denotes ,
T12194 758-766 RB denotes 3.9-fold
T12193 756-757 SYM denotes -
T12192 752-755 CC denotes and
T12191 743-751 RB denotes 5.3-fold
T12190 741-742 SYM denotes -
T12189 768-780 RB denotes respectively
T12188 740-741 -LRB- denotes (
T12187 726-739 VBN denotes downregulated
T12186 723-725 IN denotes as
T12185 707-711 VBD denotes were
T12184 701-706 NN denotes Pygo2
T12183 697-700 CC denotes and
T12433 3969-3977 NN denotes Timeless
T12432 3968-4167 sentence denotes Timeless, a transcription factor involved in the regulation of circadian rhythms, and expressed in the branching ureteric tips, has also been shown to regulate ureteric branching morphogenesis [28].
T12431 3967-3968 . denotes .
T12430 3966-3967 -RRB- denotes ]
T12429 3964-3966 CD denotes 27
T12428 3963-3964 -LRB- denotes [
T12427 3956-3962 NN denotes system
T12426 3950-3951 HYPH denotes -
T12425 3951-3955 NN denotes duct
T12424 3940-3950 NN denotes collecting
T12423 3936-3939 CC denotes and
T12422 3929-3935 NN denotes ureter
T12421 3925-3928 DT denotes the
T12420 3922-3924 IN denotes of
T12419 3908-3921 NNS denotes abnormalities
T12418 3897-3907 JJ denotes congenital
T12417 3894-3896 IN denotes in
T12416 3874-3885 NN denotes development
T12415 3867-3873 IN denotes during
T12414 3847-3848 HYPH denotes -
T12413 3848-3859 NN denotes angiotensin
T12412 3842-3847 NN denotes renin
T12411 3860-3866 NN denotes system
T12410 3838-3841 DT denotes the
T12409 3835-3837 IN denotes of
T12408 3886-3893 VBZ denotes results
T12407 3824-3834 NN denotes Disruption
T12406 3823-3968 sentence denotes Disruption of the renin-angiotensin system during development results in congenital abnormalities of the ureter and collecting-duct system [27].
T12405 3822-3823 . denotes .
T12404 3821-3822 -RRB- denotes ]
T12403 3819-3821 CD denotes 26
T12402 3818-3819 -LRB- denotes [
T12401 3809-3817 NN denotes pressure
T12400 3803-3808 NN denotes blood
T12399 3792-3802 VBG denotes increasing
T12167 647-650 CC denotes and
T12166 645-647 , denotes ,
T12165 641-645 CD denotes 0.05
T12164 640-641 SYM denotes <
T12163 637-639 IN denotes of
T12162 623-624 HYPH denotes -
T12161 624-629 NN denotes value
T12160 622-623 NN denotes p
T12159 630-636 NN denotes cutoff
T12158 620-621 DT denotes a
T12157 615-619 IN denotes with
T12156 613-615 , denotes ,
T12155 609-613 NNS denotes data
T12154 605-608 DT denotes the
T12153 602-604 IN denotes of
T12152 584-594 NN denotes stringency
T12151 580-583 JJ denotes low
T12150 569-579 RB denotes relatively
T12149 595-601 NN denotes screen
T12148 567-568 DT denotes a
T12147 561-566 VBG denotes using
T12146 559-561 , denotes ,
T12145 552-559 VBN denotes changed
T12144 538-551 RB denotes significantly
T12143 535-537 IN denotes as
T12142 519-523 VBD denotes were
T12141 513-518 NNS denotes genes
T12140 510-512 CD denotes 45
T12139 508-510 , denotes ,
T12138 503-508 JJ denotes total
T12137 524-534 VBN denotes identified
T12136 500-502 IN denotes In
T12135 499-676 sentence denotes In total, 45 genes were identified as significantly changed, using a relatively low stringency screen of the data, with a p-value cutoff of <0.05, and fold change >2 (Table 3).
T12134 498-499 . denotes .
T12133 488-498 NN denotes triplicate
T12132 477-487 JJ denotes biological
T12131 474-476 IN denotes in
T12130 460-464 VBD denotes were
T12129 465-473 VBN denotes examined
T12128 450-451 SYM denotes -
T12127 449-450 HYPH denotes /
T12126 448-449 SYM denotes -
T12125 443-448 NN denotes Pygo2
T12124 442-443 HYPH denotes /
T12123 441-442 SYM denotes -
T12122 440-441 HYPH denotes /
T12121 439-440 SYM denotes -
T12120 434-439 NN denotes Pygo1
T12119 430-433 CC denotes and
T12118 424-425 HYPH denotes -
T12117 425-429 NN denotes type
T12116 420-424 JJ denotes wild
T12115 452-459 NNS denotes kidneys
T12114 414-419 NN denotes E18.5
T12113 413-499 sentence denotes E18.5 wild-type and Pygo1-/-/Pygo2-/- kidneys were examined in biological triplicate.
T12112 412-413 . denotes .
T12111 401-404 NN denotes Wnt
T12110 395-400 VBN denotes known
T12109 405-412 NNS denotes targets
T12108 391-394 DT denotes all
T12107 381-390 VBG denotes including
T12106 379-381 , denotes ,
T12105 374-379 NNS denotes genes
T12104 370-373 DT denotes all
T12103 367-369 IN denotes of
T12102 359-366 NNS denotes changes
T12101 348-358 NN denotes expression
T12100 341-347 VB denotes follow
T12099 338-340 TO denotes to
T12098 330-332 VB denotes be
T12097 326-329 MD denotes can
T12096 314-325 NNS denotes microarrays
T12095 312-314 , denotes ,
T12094 303-312 NN denotes signaling
T12093 299-302 NN denotes Wnt
T12092 296-298 IN denotes to
T12091 287-295 NN denotes promoter
T12090 283-286 CD denotes one
T12089 280-282 IN denotes of
T12088 271-279 NN denotes response
T12087 267-270 DT denotes the
T12086 333-337 VBN denotes used
T12085 239-248 NN denotes transgene
T12084 234-235 HYPH denotes -
T12083 235-238 NN denotes gal
T12082 231-234 NN denotes BAT
T12081 249-257 NN denotes reporter
T12080 227-230 DT denotes the
T12079 258-266 VBZ denotes monitors
T12078 219-226 IN denotes Whereas
T12077 218-413 sentence denotes Whereas the BAT-gal transgene reporter monitors the response of one promoter to Wnt signaling, microarrays can be used to follow expression changes of all genes, including all known Wnt targets.
T12076 217-218 . denotes .
T12075 210-217 NNS denotes changes
T12074 199-209 NN denotes expression
T12073 194-198 NN denotes gene
T12072 191-193 IN denotes of
T12071 175-181 JJ denotes global
T12070 182-190 NN denotes analysis
T12069 173-174 DT denotes a
T12068 165-172 VB denotes perform
T12067 162-164 TO denotes to
T12066 150-161 NNS denotes microarrays
T12065 142-144 PRP denotes we
T12064 140-142 , denotes ,
T12063 126-132 NN denotes mutant
T12062 119-120 HYPH denotes /
T12061 120-125 NN denotes Pygo2
T12060 114-119 NN denotes Pygo1
T12059 133-140 NNS denotes kidneys
T12058 110-113 DT denotes the
T12057 107-109 IN denotes in
T12056 96-106 NN denotes expression
T12055 91-95 NN denotes gene
T12054 88-90 IN denotes of
T12053 76-87 NN denotes disturbance
T12052 67-75 JJ denotes possible
T12051 145-149 VBD denotes used
T12050 51-58 RB denotes further
T12049 59-66 VB denotes examine
T12048 48-50 TO denotes To
T12047 47-218 sentence denotes To further examine possible disturbance of gene expression in the Pygo1/Pygo2 mutant kidneys, we used microarrays to perform a global analysis of gene expression changes.
T12046 40-47 NNS denotes kidneys
T12045 35-39 JJ denotes null
T12044 28-29 HYPH denotes /
T12043 29-34 NN denotes Pygo2
T12042 23-28 NN denotes Pygo1
T12041 20-22 IN denotes of
T12040 11-19 NN denotes analysis
T12039 0-10 NN denotes Microarray
T12182 691-696 NN denotes Pygo1
T12181 686-690 CC denotes both
T12180 684-686 , denotes ,
T12179 712-722 VBN denotes identified
T12178 677-684 RB denotes Notably
T12177 676-804 sentence denotes Notably, both Pygo1 and Pygo2 were identified as downregulated (- 5.3-fold and - 3.9-fold, respectively) in the mutant kidneys.
T12176 675-676 . denotes .
T12175 674-675 -RRB- denotes )
T12174 673-674 CD denotes 3
T12173 667-672 NN denotes Table
T12172 666-667 -LRB- denotes (
T12171 664-665 CD denotes 2
T12170 663-664 SYM denotes >
T12169 656-662 NN denotes change
T12168 651-655 NN denotes fold
T12215 879-880 SYM denotes -
T27315 5136-5140 IN denotes from
T27314 5122-5126 VBD denotes were
T27313 5127-5135 VBN denotes selected
T27312 5110-5113 NN denotes Wnt
T27311 5114-5121 NNS denotes targets
T27377 5459-5460 . denotes .
T27376 5453-5459 NNS denotes levels
T27375 5442-5452 NN denotes expression
T27374 5439-5441 IN denotes in
T27373 5431-5438 NNS denotes changes
T27372 5419-5430 JJ denotes significant
T27661 5921-5924 DT denotes the
T27660 5918-5920 IN denotes in
T27659 5910-5917 NNS denotes changes
T27658 5899-5909 NN denotes expression
T27657 5894-5898 NN denotes gene
T27656 5891-5893 IN denotes of
T27655 5880-5890 NN denotes Validation
T27599 1499-1500 . denotes .
T27598 1492-1499 NNS denotes samples
T27597 1486-1487 HYPH denotes -
T27596 1487-1491 NN denotes type
T27595 1482-1486 JJ denotes wild
T27594 1479-1481 IN denotes to
T27593 1468-1478 VBN denotes normalized
T27592 1455-1460 NN denotes E18.5
T27591 1450-1454 JJ denotes null
T27590 1443-1444 HYPH denotes /
T27675 5993-5994 . denotes .
T27674 5980-5981 HYPH denotes -
T27673 5981-5985 NN denotes type
T27672 5976-5980 JJ denotes wild
T27671 5986-5993 NNS denotes kidneys
T27670 5970-5975 NN denotes E18.5
T27669 5967-5969 IN denotes to
T27668 5956-5966 VBN denotes normalized
T27667 5943-5947 JJ denotes null
T27666 5936-5937 HYPH denotes /
T27665 5937-5942 NN denotes Pygo2
T27664 5931-5936 NN denotes Pygo1
T27663 5925-5930 NN denotes E18.5
T27662 5948-5955 NNS denotes kidneys
T12301 1298-1299 DT denotes a
T12300 1287-1292 MD denotes might
T12299 1274-1275 HYPH denotes /
T12298 1275-1280 NN denotes Pygo2
T12297 1269-1274 NN denotes Pygo1
T12296 1281-1286 NNS denotes genes
T12295 1265-1268 DT denotes the
T12294 1293-1297 VB denotes play
T12293 1260-1264 IN denotes that
T12292 1252-1259 VBP denotes suggest
T12291 1244-1251 NNS denotes results
T12290 1238-1243 DT denotes These
T12289 1237-1351 sentence denotes These results suggest that the Pygo1/Pygo2 genes might play a role in nephron maturation and subsequent function.
T12288 1236-1237 . denotes .
T12596 4813-4815 IN denotes of
T12595 4802-4812 NN denotes expression
T12594 4799-4801 IN denotes in
T12593 4791-4798 NNS denotes changes
T12592 4782-4790 JJ denotes dramatic
T12591 4779-4781 IN denotes of
T12590 4771-4778 NN denotes absence
T12589 4768-4770 DT denotes an
T12588 4759-4767 VBP denotes indicate
T12587 4751-4758 NNS denotes results
T12586 4745-4750 DT denotes These
T12585 4744-4894 sentence denotes These results indicate an absence of dramatic changes in expression of previously known Wnt signaling target genes in the Pygo1/Pygo2 mutant kidneys.
T12584 4743-4744 . denotes .
T12583 4736-4743 NNS denotes kidneys
T12582 4731-4735 JJ denotes null
T12581 4724-4725 HYPH denotes /
T12580 4725-4730 NN denotes Pygo2
T12579 4719-4724 NN denotes Pygo1
T12578 4716-4718 IN denotes in
T12577 4707-4715 RB denotes 1.5-fold
T12576 4706-4707 SYM denotes <
T12575 4703-4705 IN denotes of
T12574 4695-4702 NNS denotes changes
T12573 4689-4694 NN denotes level
T12572 4678-4688 NN denotes expression
T12614 5469-5481 JJ denotes quantitative
T12613 5464-5468 VBD denotes used
T12612 5461-5463 PRP denotes We
T12611 4894-5569 sentence denotes Figure 8 Gene expression changes of common Wnt signaling targets in the E18.5 Pygo1/Pygo2 null kidney. Microarray analysis was performed in triplicate on wild-type and Pygo1/2 compound null E18.5 kidneys. Possible Wnt targets were selected from those compiled at [39]. An initial gene list of 82 Wnt targets was created and then reduced to a total of 40 genes using an expression level restriction requiring the raw expression intensity to be >100 in at least 3 samples. Pygo1 and Pygo2 probes were included to demonstrate significant changes in expression levels. We used quantitative real-time PCR, with independent biological samples, to validate the microarray results.
T12651 5671-5680 VBN denotes predicted
T12650 5656-5660 JJ denotes same
T12316 3401-3403 IN denotes in
T12315 3389-3400 VBN denotes upregulated
T12314 3432-3440 VBN denotes included
T12313 3383-3388 NNS denotes genes
T12312 3372-3382 JJ denotes Noteworthy
T12311 3372-3516 sentence denotes Noteworthy genes upregulated in the Pygo1/Pygo2 null kidney included Klk5 (2.8-fold), Klk6 (2.7-fold), Ren2 (2.2-fold), and Timeless (2.4-fold).
T12310 1351-1352 sentence denotes
T12309 1350-1351 . denotes .
T12308 1342-1350 NN denotes function
T12307 1331-1341 JJ denotes subsequent
T12306 1327-1330 CC denotes and
T12305 1316-1326 NN denotes maturation
T12304 1308-1315 NN denotes nephron
T12303 1305-1307 IN denotes in
T12302 1300-1304 NN denotes role
T12362 3602-3613 NNS denotes Kallikreins
T12610 4893-4894 . denotes .
T12609 4879-4885 NN denotes mutant
T12608 4872-4873 HYPH denotes /
T12607 4873-4878 NN denotes Pygo2
T12606 4867-4872 NN denotes Pygo1
T12605 4886-4893 NNS denotes kidneys
T12604 4863-4866 DT denotes the
T12603 4860-4862 IN denotes in
T12602 4847-4853 NN denotes target
T12601 4837-4846 NN denotes signaling
T12600 4833-4836 NN denotes Wnt
T12599 4854-4859 NNS denotes genes
T12598 4827-4832 VBN denotes known
T12597 4816-4826 RB denotes previously
T12649 5661-5670 NN denotes direction
T12648 5652-5655 DT denotes the
T12647 5649-5651 IN denotes in
T12646 5637-5641 NN denotes fold
T12645 5625-5636 JJ denotes significant
T12644 5642-5648 NN denotes change
T12643 5623-5624 DT denotes a
T12642 5611-5614 VBD denotes did
T12641 5608-5610 PRP denotes we
T12640 5602-5607 CD denotes seven
T12639 5615-5622 VB denotes observe
T12638 5598-5601 IN denotes for
T12637 5594-5597 CC denotes and
T12636 5592-5594 , denotes ,
T12635 5581-5585 VBD denotes were
T12634 5586-5592 VBN denotes tested
T12633 5575-5580 NNS denotes genes
T12632 5570-5574 CD denotes Nine
T12631 5569-5717 sentence denotes Nine genes were tested, and for seven we did observe a significant fold change in the same direction predicted by the microarray results (Table 4).
T12630 5568-5569 . denotes .
T12629 5550-5560 NN denotes microarray
T12628 5561-5568 NNS denotes results
T12627 5546-5549 DT denotes the
T12626 5537-5545 VB denotes validate
T12625 5534-5536 TO denotes to
T12624 5532-5534 , denotes ,
T12623 5514-5524 JJ denotes biological
T12622 5525-5532 NNS denotes samples
T12621 5502-5513 JJ denotes independent
T12620 5497-5501 IN denotes with
T12619 5495-5497 , denotes ,
T12618 5486-5487 HYPH denotes -
T12617 5487-5491 NN denotes time
T12616 5482-5486 JJ denotes real
T12615 5492-5495 NN denotes PCR
R3017 T12039 T12040 compound Microarray,analysis
R3018 T12041 T12040 prep of,analysis
R3019 T12042 T12043 compound Pygo1,Pygo2
R3020 T12043 T12045 npadvmod Pygo2,null
R3021 T12044 T12043 punct /,Pygo2
R3022 T12045 T12046 amod null,kidneys
R3023 T12046 T12041 pobj kidneys,of
R3024 T12048 T12049 aux To,examine
R3025 T12049 T12051 advcl examine,used
R3026 T12050 T12049 advmod further,examine
R3027 T12052 T12053 amod possible,disturbance
R3028 T12053 T12049 dobj disturbance,examine
R3029 T12054 T12053 prep of,disturbance
R3030 T12055 T12056 compound gene,expression
R3031 T12056 T12054 pobj expression,of
R3032 T12057 T12049 prep in,examine
R3033 T12058 T12059 det the,kidneys
R3034 T12059 T12057 pobj kidneys,in
R3035 T12060 T12061 compound Pygo1,Pygo2
R3036 T12061 T12059 compound Pygo2,kidneys
R3037 T12062 T12061 punct /,Pygo2
R3038 T12063 T12059 compound mutant,kidneys
R3039 T12064 T12051 punct ", ",used
R3040 T12065 T12051 nsubj we,used
R3041 T12066 T12051 dobj microarrays,used
R3042 T12067 T12068 aux to,perform
R3043 T12068 T12051 advcl perform,used
R3044 T12069 T12070 det a,analysis
R3045 T12070 T12068 dobj analysis,perform
R3046 T12071 T12070 amod global,analysis
R3047 T12072 T12070 prep of,analysis
R3048 T12073 T12074 compound gene,expression
R3049 T12074 T12075 compound expression,changes
R3050 T12075 T12072 pobj changes,of
R3051 T12076 T12051 punct .,used
R3052 T12078 T12079 mark Whereas,monitors
R3053 T12079 T12086 advcl monitors,used
R3054 T12080 T12081 det the,reporter
R3055 T12081 T12079 nsubj reporter,monitors
R3056 T12082 T12083 compound BAT,gal
R3057 T12083 T12085 compound gal,transgene
R3058 T12084 T12083 punct -,gal
R3059 T12085 T12081 compound transgene,reporter
R3060 T12087 T12088 det the,response
R3061 T12088 T12079 dobj response,monitors
R3062 T12089 T12088 prep of,response
R3063 T12090 T12091 nummod one,promoter
R3064 T12091 T12089 pobj promoter,of
R3065 T12092 T12088 prep to,response
R3066 T12093 T12094 compound Wnt,signaling
R3067 T12094 T12092 pobj signaling,to
R3068 T12095 T12086 punct ", ",used
R3069 T12096 T12086 nsubjpass microarrays,used
R3070 T12097 T12086 aux can,used
R3071 T12098 T12086 auxpass be,used
R3072 T12099 T12100 aux to,follow
R3073 T12100 T12086 advcl follow,used
R3074 T12101 T12102 compound expression,changes
R3075 T12102 T12100 dobj changes,follow
R3076 T12103 T12102 prep of,changes
R3077 T12104 T12105 det all,genes
R3078 T12105 T12103 pobj genes,of
R3079 T12106 T12105 punct ", ",genes
R3080 T12107 T12105 prep including,genes
R3081 T12108 T12109 det all,targets
R3082 T12109 T12107 pobj targets,including
R3083 T12110 T12109 amod known,targets
R3084 T12111 T12109 compound Wnt,targets
R3085 T12112 T12086 punct .,used
R3086 T12114 T12115 nmod E18.5,kidneys
R3087 T12115 T12129 nsubjpass kidneys,examined
R3088 T12116 T12117 amod wild,type
R3089 T12117 T12115 nmod type,kidneys
R3090 T12118 T12117 punct -,type
R3091 T12119 T12117 cc and,type
R3092 T12120 T12117 conj Pygo1,type
R3093 T12121 T12120 punct -,Pygo1
R3094 T12122 T12120 punct /,Pygo1
R3095 T12123 T12120 punct -,Pygo1
R3096 T12124 T12120 punct /,Pygo1
R3097 T12125 T12120 appos Pygo2,Pygo1
R3098 T12126 T12125 punct -,Pygo2
R3099 T12127 T12125 punct /,Pygo2
R3100 T12128 T12125 punct -,Pygo2
R3101 T12130 T12129 auxpass were,examined
R3102 T12131 T12129 prep in,examined
R3103 T12132 T12133 amod biological,triplicate
R3104 T12133 T12131 pobj triplicate,in
R3105 T12134 T12129 punct .,examined
R3106 T12136 T12137 prep In,identified
R3107 T12138 T12136 amod total,In
R3108 T12139 T12137 punct ", ",identified
R3109 T12140 T12141 nummod 45,genes
R3110 T12141 T12137 nsubjpass genes,identified
R3111 T12142 T12137 auxpass were,identified
R3112 T12143 T12137 prep as,identified
R3113 T12144 T12145 advmod significantly,changed
R3114 T12145 T12143 amod changed,as
R3115 T12146 T12137 punct ", ",identified
R3116 T12147 T12137 advcl using,identified
R3117 T12148 T12149 det a,screen
R3118 T12149 T12147 dobj screen,using
R3119 T12150 T12151 advmod relatively,low
R3120 T12151 T12149 amod low,screen
R3121 T12152 T12149 compound stringency,screen
R3122 T12153 T12149 prep of,screen
R3123 T12154 T12155 det the,data
R3124 T12155 T12153 pobj data,of
R3125 T12156 T12137 punct ", ",identified
R3126 T12157 T12137 prep with,identified
R3127 T12158 T12159 det a,cutoff
R3128 T12159 T12157 pobj cutoff,with
R3129 T12160 T12161 compound p,value
R3130 T12161 T12159 compound value,cutoff
R3131 T12162 T12161 punct -,value
R3132 T12163 T12159 prep of,cutoff
R3133 T12164 T12165 punct <,0.05
R3134 T12165 T12163 pobj 0.05,of
R3135 T12166 T12159 punct ", ",cutoff
R3136 T12167 T12159 cc and,cutoff
R3137 T12168 T12169 compound fold,change
R3138 T12169 T12159 conj change,cutoff
R3139 T12170 T12171 punct >,2
R3140 T12171 T12169 appos 2,change
R3141 T12172 T12173 punct (,Table
R3142 T12173 T12137 parataxis Table,identified
R3143 T12174 T12173 nummod 3,Table
R3144 T12175 T12173 punct ),Table
R3145 T12176 T12137 punct .,identified
R3146 T12178 T12179 advmod Notably,identified
R3147 T12180 T12179 punct ", ",identified
R3148 T12181 T12182 preconj both,Pygo1
R3149 T12182 T12179 nsubjpass Pygo1,identified
R3150 T12183 T12182 cc and,Pygo1
R3151 T12184 T12182 conj Pygo2,Pygo1
R3152 T12185 T12179 auxpass were,identified
R3153 T12186 T12179 prep as,identified
R3154 T12187 T12186 amod downregulated,as
R3155 T12188 T12189 punct (,respectively
R3156 T12189 T12187 parataxis respectively,downregulated
R3157 T12190 T12191 punct -,5.3-fold
R3158 T12191 T12189 advmod 5.3-fold,respectively
R3159 T12192 T12191 cc and,5.3-fold
R3160 T12193 T12194 punct -,3.9-fold
R3161 T12194 T12191 conj 3.9-fold,5.3-fold
R3162 T12195 T12189 punct ", ",respectively
R3163 T12196 T12189 punct ),respectively
R3164 T12197 T12179 prep in,identified
R3165 T12198 T12199 det the,kidneys
R3166 T12199 T12197 pobj kidneys,in
R3167 T12200 T12199 compound mutant,kidneys
R3168 T12201 T12179 punct .,identified
R3169 T12203 T12204 amod Other,genes
R3170 T12204 T12205 nsubj genes,included
R3171 T12206 T12204 prep with,genes
R3172 T12207 T12208 amod significant,decreases
R3173 T12208 T12206 pobj decreases,with
R3174 T12209 T12208 prep in,decreases
R3175 T12210 T12211 compound mutant,kidneys
R3176 T12211 T12209 pobj kidneys,in
R3177 T12212 T12205 dobj Cxcl13,included
R3178 T12213 T12214 punct (,2.3-fold
R3179 T12214 T12212 parataxis 2.3-fold,Cxcl13
R3180 T12215 T12214 punct -,2.3-fold
R3181 T12216 T12214 punct ),2.3-fold
R3182 T12217 T12212 punct ", ",Cxcl13
R3183 T12218 T12212 conj Slc5a2,Cxcl13
R3184 T12219 T12220 punct (,2.8-fold
R3185 T12220 T12218 parataxis 2.8-fold,Slc5a2
R3186 T12221 T12220 punct -,2.8-fold
R3187 T12222 T12220 punct ),2.8-fold
R3188 T12223 T12218 punct ", ",Slc5a2
R3189 T12224 T12218 cc and,Slc5a2
R3190 T12225 T12218 conj Slco1a4,Slc5a2
R3191 T12226 T12227 punct (,2.1-fold
R3192 T12227 T12225 parataxis 2.1-fold,Slco1a4
R3193 T12228 T12227 punct -,2.1-fold
R3194 T12229 T12227 punct ),2.1-fold
R3195 T12230 T12205 punct .,included
R3196 T12232 T12233 nsubjpass Slc5a2,expressed
R3197 T12234 T12233 auxpass is,expressed
R3198 T12235 T12233 prep in,expressed
R3199 T12236 T12237 det the,tubules
R3200 T12237 T12235 pobj tubules,in
R3201 T12238 T12237 amod proximal,tubules
R3202 T12239 T12237 prep of,tubules
R3203 T12240 T12241 det the,nephron
R3204 T12241 T12239 pobj nephron,of
R3205 T12242 T12241 amod adult,nephron
R3206 T12243 T12233 cc and,expressed
R3207 T12244 T12245 aux has,implicated
R3208 T12245 T12233 conj implicated,expressed
R3209 T12246 T12245 auxpass been,implicated
R3210 T12247 T12245 prep in,implicated
R3211 T12248 T12249 amod autosomal,recessive
R3212 T12249 T12250 amod recessive,glucosuria
R3213 T12250 T12247 pobj glucosuria,in
R3214 T12251 T12250 amod renal,glucosuria
R3215 T12252 T12250 punct ", ",glucosuria
R3216 T12253 T12250 acl characterized,glucosuria
R3217 T12254 T12253 agent by,characterized
R3218 T12255 T12254 pobj loss,by
R3219 T12256 T12255 prep of,loss
R3220 T12257 T12258 compound glucose,uptake
R3221 T12258 T12256 pobj uptake,of
R3222 T12259 T12258 prep by,uptake
R3223 T12260 T12261 det the,nephron
R3224 T12261 T12259 pobj nephron,by
R3225 T12262 T12263 punct [,23
R3226 T12263 T12253 parataxis 23,characterized
R3227 T12264 T12263 punct ],23
R3228 T12265 T12233 punct .,expressed
R3229 T12267 T12268 det The,transporter
R3230 T12268 T12271 nsubjpass transporter,expressed
R3231 T12269 T12268 amod organic,transporter
R3232 T12270 T12268 compound anion,transporter
R3233 T12272 T12268 punct ", ",transporter
R3234 T12273 T12268 appos Slco1a4,transporter
R3235 T12274 T12271 punct ", ",expressed
R3236 T12275 T12271 auxpass is,expressed
R3237 T12276 T12271 advmod also,expressed
R3266 T12307 T12308 amod subsequent,function
R3267 T12308 T12305 conj function,maturation
R3268 T12309 T12292 punct .,suggest
R3269 T12312 T12313 amod Noteworthy,genes
R3270 T12313 T12314 nsubj genes,included
R3271 T12315 T12313 acl upregulated,genes
R3272 T12316 T12315 prep in,upregulated
R3273 T12317 T12318 det the,kidney
R3274 T12318 T12316 pobj kidney,in
R3275 T12319 T12320 compound Pygo1,Pygo2
R3276 T12320 T12322 npadvmod Pygo2,null
R3277 T12321 T12320 punct /,Pygo2
R3278 T12322 T12318 amod null,kidney
R3279 T12323 T12314 dobj Klk5,included
R3280 T12324 T12325 punct (,2.8-fold
R3281 T12325 T12323 parataxis 2.8-fold,Klk5
R3282 T12326 T12325 punct ),2.8-fold
R3283 T12327 T12323 punct ", ",Klk5
R3284 T12328 T12323 conj Klk6,Klk5
R3285 T12329 T12330 punct (,2.7-fold
R3286 T12330 T12328 parataxis 2.7-fold,Klk6
R3287 T12331 T12330 punct ),2.7-fold
R3288 T12332 T12328 punct ", ",Klk6
R3289 T12333 T12328 conj Ren2,Klk6
R3290 T12334 T12335 punct (,2.2-fold
R3291 T12335 T12333 parataxis 2.2-fold,Ren2
R3292 T12336 T12335 punct ),2.2-fold
R3293 T12337 T12333 punct ", ",Ren2
R3294 T12338 T12333 cc and,Ren2
R3295 T12339 T12333 conj Timeless,Ren2
R3296 T12340 T12341 punct (,2.4-fold
R3297 T12341 T12339 parataxis 2.4-fold,Timeless
R3298 T12342 T12341 punct ),2.4-fold
R3299 T12343 T12314 punct .,included
R3300 T12345 T12346 nsubj Klk5,are
R3301 T12347 T12345 cc and,Klk5
R3302 T12348 T12345 conj Klk6,Klk5
R3303 T12349 T12346 attr members,are
R3304 T12350 T12349 prep of,members
R3305 T12351 T12352 det the,family
R3306 T12352 T12350 pobj family,of
R3307 T12353 T12352 compound kallikrein,family
R3308 T12354 T12352 prep of,family
R3309 T12355 T12356 npadvmod trypsin,like
R3310 T12356 T12358 amod like,proteases
R3311 T12357 T12356 punct -,like
R3312 T12358 T12354 pobj proteases,of
R3313 T12359 T12358 compound serine,proteases
R3314 T12360 T12346 punct .,are
R3315 T12362 T12363 nsubj Kallikreins,have
R3316 T12364 T12365 amod diverse,functions
R3317 T12365 T12363 dobj functions,have
R3318 T12366 T12363 prep in,have
R3319 T12367 T12366 pobj cancer,in
R3320 T12368 T12367 punct ", ",cancer
R3321 T12369 T12370 compound tissue,remodeling
R3322 T12370 T12367 conj remodeling,cancer
R3323 T12371 T12370 punct ", ",remodeling
R3324 T12372 T12370 cc and,remodeling
R3325 T12373 T12370 conj regulation,remodeling
R3326 T12374 T12373 prep of,regulation
R3327 T12375 T12376 compound blood,pressure
R3328 T12376 T12374 pobj pressure,of
R3329 T12377 T12378 punct [,25
R3330 T12378 T12363 parataxis 25,have
R3331 T12379 T12378 punct ],25
R3332 T12380 T12363 punct .,have
R3333 T12382 T12383 nsubj Ren2,activates
R3334 T12384 T12382 punct ", ",Ren2
R3335 T12385 T12386 det a,homolog
R3336 T12386 T12382 appos homolog,Ren2
R3337 T12387 T12386 prep of,homolog
R3338 T12388 T12389 det the,endopeptidase
R3339 T12389 T12387 pobj endopeptidase,of
R3340 T12390 T12389 appos Renin,endopeptidase
R3341 T12391 T12390 nummod 1,Renin
R3342 T12392 T12383 punct ", ",activates
R3343 T12393 T12394 det the,system
R3344 T12394 T12383 dobj system,activates
R3345 T12395 T12396 compound renin,angiotensin
R3346 T12396 T12394 compound angiotensin,system
R3347 T12397 T12396 punct -,angiotensin
R3348 T12398 T12383 punct ", ",activates
R3349 T12399 T12383 advcl increasing,activates
R3350 T12400 T12401 compound blood,pressure
R3351 T12401 T12399 dobj pressure,increasing
R3352 T12402 T12403 punct [,26
R3353 T12403 T12383 parataxis 26,activates
R3354 T12404 T12403 punct ],26
R3355 T12405 T12383 punct .,activates
R3356 T12407 T12408 nsubj Disruption,results
R3357 T12409 T12407 prep of,Disruption
R3358 T12410 T12411 det the,system
R3359 T12411 T12409 pobj system,of
R3360 T12412 T12413 compound renin,angiotensin
R3361 T12413 T12411 compound angiotensin,system
R3362 T12414 T12413 punct -,angiotensin
R3363 T12415 T12407 prep during,Disruption
R3364 T12416 T12415 pobj development,during
R3365 T12417 T12408 prep in,results
R3366 T12418 T12419 amod congenital,abnormalities
R3367 T12419 T12417 pobj abnormalities,in
R3368 T12420 T12419 prep of,abnormalities
R3369 T12421 T12422 det the,ureter
R3370 T12422 T12420 pobj ureter,of
R3371 T12423 T12422 cc and,ureter
R3372 T12424 T12425 compound collecting,duct
R3373 T12425 T12427 compound duct,system
R3374 T12426 T12425 punct -,duct
R3375 T12427 T12422 conj system,ureter
R3376 T12428 T12429 punct [,27
R3377 T12429 T12408 parataxis 27,results
R3378 T12430 T12429 punct ],27
R3379 T12431 T12408 punct .,results
R3380 T12433 T12434 nsubjpass Timeless,shown
R3381 T12435 T12433 punct ", ",Timeless
R3382 T12436 T12437 det a,factor
R3383 T12437 T12433 appos factor,Timeless
R3384 T12438 T12437 compound transcription,factor
R3385 T12439 T12437 acl involved,factor
R3386 T12440 T12439 prep in,involved
R3387 T12441 T12442 det the,regulation
R3388 T12442 T12440 pobj regulation,in
R3389 T12443 T12442 prep of,regulation
R3390 T12444 T12445 amod circadian,rhythms
R3391 T12445 T12443 pobj rhythms,of
R3392 T12446 T12439 punct ", ",involved
R3393 T12447 T12439 cc and,involved
R3394 T12448 T12439 conj expressed,involved
R3395 T12449 T12448 prep in,expressed
R3396 T12450 T12451 det the,tips
R3397 T12451 T12449 pobj tips,in
R3398 T12452 T12451 amod branching,tips
R3399 T12453 T12451 amod ureteric,tips
R3400 T12454 T12434 punct ", ",shown
R3401 T12455 T12434 aux has,shown
R3402 T12456 T12434 advmod also,shown
R3403 T12457 T12434 auxpass been,shown
R3404 T12458 T12459 aux to,regulate
R3405 T12459 T12434 xcomp regulate,shown
R3406 T12460 T12461 amod ureteric,morphogenesis
R3407 T12461 T12459 dobj morphogenesis,regulate
R3408 T12462 T12461 compound branching,morphogenesis
R3409 T12463 T12464 punct [,28
R3410 T12464 T12434 parataxis 28,shown
R3411 T12465 T12464 punct ],28
R3412 T12466 T12434 punct .,shown
R3413 T12468 T12469 nsubj We,were
R3414 T12470 T12469 acomp interested,were
R3415 T12471 T12470 prep in,interested
R3416 T12472 T12473 det the,expression
R3417 T12473 T12471 pobj expression,in
R3418 T12474 T12473 amod possible,expression
R3419 T12475 T12473 amod altered,expression
R3420 T12476 T12473 prep of,expression
R3421 T12477 T12478 advmod previously,known
R3422 T12478 T12479 amod known,targets
R3423 T12479 T12476 pobj targets,of
R3424 T12480 T12479 compound Wnt,targets
R3425 T12481 T12469 prep in,were
R3426 T12482 T12483 det the,kidneys
R3427 T12483 T12481 pobj kidneys,in
R3428 T12484 T12485 nmod Pygo1,mutant
R3429 T12485 T12483 compound mutant,kidneys
R3430 T12486 T12484 punct -,Pygo1
R3431 T12487 T12484 punct /,Pygo1
R3432 T12488 T12484 punct -,Pygo1
R3433 T12489 T12484 punct /,Pygo1
R3434 T12490 T12484 appos Pygo2,Pygo1
R3435 T12491 T12490 punct -,Pygo2
R3436 T12492 T12490 punct /,Pygo2
R3437 T12493 T12490 punct -,Pygo2
R3438 T12494 T12469 punct .,were
R3439 T12496 T12497 det A,list
R3440 T12497 T12498 nsubjpass list,compiled
R3441 T12499 T12497 prep of,list
R3442 T12500 T12501 amod known,targets
R3443 T12501 T12499 pobj targets,of
R3444 T12502 T12501 compound Wnt,targets
R3445 T12503 T12498 auxpass was,compiled
R3446 T12504 T12498 prep from,compiled
R3447 T12505 T12498 punct .,compiled
R3448 T12507 T12508 preconj Both,Pygo1
R3449 T12508 T12509 nmod Pygo1,sets
R3450 T12509 T12513 nsubjpass sets,included
R3451 T12510 T12508 cc and,Pygo1
R3452 T12511 T12508 conj Pygo2,Pygo1
R3453 T12512 T12509 compound probe,sets
R3454 T12514 T12513 auxpass were,included
R3455 T12515 T12513 prep as,included
R3456 T12516 T12515 pobj references,as
R3457 T12517 T12518 aux to,illustrate
R3458 T12518 T12513 advcl illustrate,included
R3459 T12519 T12520 amod significant,regulation
R3460 T12520 T12518 dobj regulation,illustrate
R3461 T12521 T12520 amod down,regulation
R3462 T12522 T12513 punct .,included
R3463 T12524 T12525 advmod Remarkably,showed
R3464 T12526 T12525 punct ", ",showed
R3465 T12527 T12528 det the,genes
R3466 T12528 T12525 nsubj genes,showed
R3467 T12529 T12528 amod known,genes
R3468 T12530 T12531 compound Wnt,target
R3469 T12531 T12528 compound target,genes
R3470 T12532 T12533 advmod very,few
R3471 T12533 T12534 amod few,differences
R3472 T12534 T12525 dobj differences,showed
R3473 T12535 T12534 prep in,differences
R3474 T12536 T12535 pobj expression,in
R3475 T12537 T12534 prep between,differences
R3476 T12538 T12539 amod wild,type
R3477 T12539 T12541 nmod type,kidneys
R3478 T12540 T12539 punct -,type
R3479 T12541 T12537 pobj kidneys,between
R3480 T12542 T12539 cc and,type
R3481 T12543 T12539 conj mutant,type
R3482 T12544 T12545 punct (,Figure
R3483 T12545 T12525 parataxis Figure,showed
R3484 T12546 T12545 nummod 8,Figure
R3485 T12547 T12545 punct ),Figure
R3486 T12548 T12525 punct .,showed
R3487 T12550 T12551 advmod Only,expression
R3488 T12551 T12553 nsubjpass expression,changed
R3489 T12552 T12551 det the,expression
R3490 T12554 T12551 prep of,expression
R3491 T12555 T12556 npadvmod Ccnd1,encoding
R3492 T12556 T12557 amod encoding,D1
R3493 T12557 T12554 pobj D1,of
R3494 T12558 T12557 compound cyclin,D1
R3495 T12559 T12560 punct [,29
R3496 T12560 T12557 parataxis 29,D1
R3497 T12561 T12560 punct ],29
R3498 T12562 T12557 punct ", ",D1
R3499 T12563 T12557 cc and,D1
R3500 T12564 T12557 conj Wisp1,D1
R3501 T12565 T12566 punct [,30
R3502 T12566 T12564 parataxis 30,Wisp1
R3503 T12567 T12566 punct ],30
R3504 T12568 T12553 auxpass were,changed
R3505 T12569 T12553 advmod significantly,changed
R3506 T12570 T12553 punct ", ",changed
R3507 T12571 T12553 prep with,changed
R3508 T12572 T12573 compound expression,level
R3509 T12573 T12574 compound level,changes
R3510 T12574 T12571 pobj changes,with
R3511 T12575 T12574 prep of,changes
R3512 T12576 T12577 punct <,1.5-fold
R3513 T12577 T12575 pobj 1.5-fold,of
R3514 T12578 T12574 prep in,changes
R3515 T12579 T12580 compound Pygo1,Pygo2
R3516 T12580 T12582 npadvmod Pygo2,null
R3517 T12581 T12580 punct /,Pygo2
R3518 T12582 T12583 amod null,kidneys
R3519 T12583 T12578 pobj kidneys,in
R3520 T12584 T12553 punct .,changed
R3521 T12586 T12587 det These,results
R3522 T12587 T12588 nsubj results,indicate
R3523 T12589 T12590 det an,absence
R3524 T12590 T12588 dobj absence,indicate
R3525 T12591 T12590 prep of,absence
R3526 T12592 T12593 amod dramatic,changes
R3527 T12593 T12591 pobj changes,of
R3528 T12594 T12593 prep in,changes
R3529 T12595 T12594 pobj expression,in
R3530 T12596 T12595 prep of,expression
R3531 T12597 T12598 advmod previously,known
R3532 T12598 T12599 amod known,genes
R3534 T12600 T12601 compound Wnt,signaling
R3573 T12643 T12644 det a,change
R3574 T12644 T12639 dobj change,observe
R3575 T12645 T12644 amod significant,change
R3576 T12646 T12644 compound fold,change
R3577 T12647 T12644 prep in,change
R3578 T12648 T12649 det the,direction
R3579 T12649 T12647 pobj direction,in
R3580 T12650 T12649 amod same,direction
R3581 T12651 T12649 acl predicted,direction
R3582 T12652 T12651 agent by,predicted
R3583 T12653 T12654 det the,results
R3584 T12654 T12652 pobj results,by
R3585 T12655 T12654 compound microarray,results
R3586 T12656 T12657 punct (,Table
R3587 T12657 T12639 parataxis Table,observe
R3588 T12658 T12657 nummod 4,Table
R3589 T12659 T12657 punct ),Table
R3590 T12660 T12639 punct .,observe
R3591 T12662 T12663 nsubj It,is
R3592 T12664 T12665 neg not,surprising
R3593 T12665 T12663 acomp surprising,is
R3594 T12666 T12667 mark that,validated
R3595 T12667 T12663 ccomp validated,is
R3596 T12668 T12667 nsubjpass two,validated
R3597 T12669 T12668 prep of,two
R3598 T12670 T12671 det the,genes
R3599 T12671 T12669 pobj genes,of
R3600 T12672 T12671 nummod nine,genes
R3601 T12673 T12667 aux could,validated
R3602 T12674 T12667 neg not,validated
R3603 T12675 T12667 auxpass be,validated
R3604 T12676 T12663 punct ", ",is
R3605 T12677 T12663 advcl considering,is
R3606 T12678 T12679 det the,stringency
R3607 T12679 T12677 dobj stringency,considering
R3608 T12680 T12681 advmod relatively,low
R3609 T12681 T12679 amod low,stringency
R3610 T12682 T12679 acl used,stringency
R3611 T12683 T12682 prep in,used
R3612 T12684 T12683 pcomp screening,in
R3613 T12685 T12686 det the,data
R3614 T12686 T12684 dobj data,screening
R3615 T12687 T12686 compound microarray,data
R3616 T12688 T12663 punct .,is
R7885 T27272 T27273 compound Gene,expression
R7886 T27273 T27274 compound expression,changes
R7887 T27275 T27274 prep of,changes
R7888 T27276 T27277 amod common,targets
R7889 T27277 T27275 pobj targets,of
R7890 T27278 T27277 compound Wnt,targets
R7891 T27279 T27277 compound signaling,targets
R7892 T27280 T27274 prep in,changes
R7893 T27281 T27282 det the,kidney
R7894 T27282 T27280 pobj kidney,in
R7895 T27283 T27282 nmod E18.5,kidney
R7896 T27284 T27285 compound Pygo1,Pygo2
R7897 T27285 T27287 npadvmod Pygo2,null
R7898 T27286 T27285 punct /,Pygo2
R7899 T27287 T27282 amod null,kidney
R7900 T27288 T27274 punct .,changes
R7901 T27290 T27291 compound Microarray,analysis
R7902 T27291 T27292 nsubjpass analysis,performed
R7903 T27293 T27292 auxpass was,performed
R7904 T27294 T27292 prep in,performed
R7905 T27295 T27294 pobj triplicate,in
R7906 T27296 T27292 prep on,performed
R7907 T27297 T27298 amod wild,type
R7908 T27298 T27300 nmod type,kidneys
R7909 T27299 T27298 punct -,type
R7910 T27300 T27296 pobj kidneys,on
R7911 T27301 T27298 cc and,type
R7912 T27302 T27303 npadvmod Pygo1,null
R7913 T27303 T27298 conj null,type
R7914 T27304 T27302 punct /,Pygo1
R7915 T27305 T27302 nummod 2,Pygo1
R7916 T27306 T27303 npadvmod compound,null
R7917 T27307 T27300 compound E18.5,kidneys
R7918 T27308 T27292 punct .,performed
R7919 T27310 T27311 amod Possible,targets
R7920 T27311 T27313 nsubjpass targets,selected
R7921 T27312 T27311 compound Wnt,targets
R7922 T27314 T27313 auxpass were,selected
R7923 T27315 T27313 prep from,selected
R7924 T27316 T27315 pobj those,from
R7925 T27317 T27316 acl compiled,those
R7926 T27318 T27317 prep at,compiled
R7927 T27319 T27318 punct [,at
R7928 T27320 T27318 pobj 39,at
R7929 T27321 T27313 punct ],selected
R7930 T27322 T27313 punct .,selected
R7931 T27324 T27325 det An,list
R7932 T27325 T27328 nsubjpass list,created
R7933 T27326 T27325 amod initial,list
R7934 T27327 T27325 compound gene,list
R7935 T27329 T27325 prep of,list
R7936 T27330 T27331 nummod 82,targets
R7937 T27331 T27329 pobj targets,of
R7938 T27332 T27331 compound Wnt,targets
R7939 T27333 T27328 auxpass was,created
R7940 T27334 T27328 cc and,created
R7941 T27335 T27336 advmod then,reduced
R7942 T27336 T27328 conj reduced,created
R7943 T27337 T27336 prep to,reduced
R7944 T27338 T27339 det a,total
R7945 T27339 T27337 pobj total,to
R7946 T27340 T27339 prep of,total
R7947 T27341 T27342 nummod 40,genes
R7948 T27342 T27340 pobj genes,of
R7949 T27343 T27336 advcl using,reduced
R7950 T27344 T27345 det an,restriction
R7951 T27345 T27343 dobj restriction,using
R7952 T27346 T27347 compound expression,level
R7953 T27347 T27345 compound level,restriction
R7954 T27348 T27345 acl requiring,restriction
R7955 T27349 T27350 det the,intensity
R7956 T27350 T27348 dobj intensity,requiring
R7957 T27351 T27350 amod raw,intensity
R7958 T27352 T27350 compound expression,intensity
R7959 T27353 T27354 aux to,be
R7960 T27354 T27348 xcomp be,requiring
R7961 T27355 T27356 punct >,100
R7962 T27356 T27354 attr 100,be
R7963 T27357 T27354 prep in,be
R7964 T27358 T27359 advmod at,3
R7965 T27359 T27361 nummod 3,samples
R7966 T27360 T27359 advmod least,3
R7967 T27361 T27357 pobj samples,in
R7968 T27362 T27328 punct .,created
R7969 T27364 T27365 nmod Pygo1,probes
R7970 T27365 T27368 nsubjpass probes,included
R7971 T27366 T27364 cc and,Pygo1
R7972 T27367 T27364 conj Pygo2,Pygo1
R7973 T27369 T27368 auxpass were,included
R7974 T27370 T27371 aux to,demonstrate
R7975 T27371 T27368 advcl demonstrate,included
R7976 T27372 T27373 amod significant,changes
R7977 T27373 T27371 dobj changes,demonstrate
R7978 T27374 T27373 prep in,changes
R7979 T27375 T27376 compound expression,levels
R7980 T27376 T27374 pobj levels,in
R7981 T27377 T27368 punct .,included
R8019 T27573 T27574 advmod differentially,expressed
R8020 T27574 T27572 acl expressed,Genes
R8021 T27575 T27576 punct (,change
R8022 T27576 T27574 parataxis change,expressed
R8023 T27577 T27578 nsubj p,0.05
R8024 T27578 T27576 ccomp 0.05,change
R8025 T27579 T27578 punct <,0.05
R8026 T27580 T27576 punct ", ",change
R8027 T27581 T27576 amod two-fold,change
R8028 T27582 T27583 cc or,greater
R8029 T27583 T27576 nummod greater,change
R8030 T27584 T27576 punct ),change
R8031 T27585 T27574 prep in,expressed
R8032 T27586 T27587 det the,kidney
R8033 T27587 T27585 pobj kidney,in
R8034 T27588 T27589 compound Pygo1,Pygo2
R8035 T27589 T27591 npadvmod Pygo2,null
R8036 T27590 T27589 punct /,Pygo2
R8037 T27591 T27587 amod null,kidney
R8038 T27592 T27587 compound E18.5,kidney
R8039 T27593 T27587 acl normalized,kidney
R8040 T27594 T27593 prep to,normalized
R8041 T27595 T27596 amod wild,type
R8042 T27596 T27598 compound type,samples
R8043 T27597 T27596 punct -,type
R8044 T27598 T27594 pobj samples,to
R8045 T27599 T27572 punct .,Genes
R8046 T27656 T27655 prep of,Validation
R8047 T27657 T27658 compound gene,expression
R8048 T27658 T27659 compound expression,changes
R8049 T27659 T27656 pobj changes,of
R8050 T27660 T27659 prep in,changes
R8051 T27661 T27662 det the,kidneys
R8052 T27662 T27660 pobj kidneys,in
R8053 T27663 T27662 nmod E18.5,kidneys
R8054 T27664 T27665 compound Pygo1,Pygo2
R8055 T27665 T27667 npadvmod Pygo2,null
R8056 T27666 T27665 punct /,Pygo2
R8057 T27667 T27662 amod null,kidneys
R8058 T27668 T27659 acl normalized,changes
R8059 T27669 T27668 prep to,normalized
R8060 T27670 T27671 nmod E18.5,kidneys
R8061 T27671 T27669 pobj kidneys,to
R8062 T27672 T27673 amod wild,type
R8063 T27673 T27671 compound type,kidneys
R8064 T27674 T27673 punct -,type
R8065 T27675 T27655 punct .,Validation
R3238 T12277 T12271 advmod strongly,expressed
R3239 T12278 T12271 prep in,expressed
R3240 T12279 T12280 det the,tubules
R3241 T12280 T12278 pobj tubules,in
R3242 T12281 T12280 prep of,tubules
R3243 T12282 T12283 det the,kidney
R3244 T12283 T12281 pobj kidney,of
R3245 T12284 T12283 amod adult,kidney
R3246 T12285 T12286 punct [,24
R3247 T12286 T12271 parataxis 24,expressed
R3248 T12287 T12286 punct ],24
R3249 T12288 T12271 punct .,expressed
R3250 T12290 T12291 det These,results
R3251 T12291 T12292 nsubj results,suggest
R3252 T12293 T12294 mark that,play
R3253 T12294 T12292 ccomp play,suggest
R3254 T12295 T12296 det the,genes
R3255 T12296 T12294 nsubj genes,play
R3256 T12297 T12298 compound Pygo1,Pygo2
R3257 T12298 T12296 compound Pygo2,genes
R3258 T12299 T12298 punct /,Pygo2
R3259 T12300 T12294 aux might,play
R3260 T12301 T12302 det a,role
R3261 T12302 T12294 dobj role,play
R3262 T12303 T12294 prep in,play
R3263 T12304 T12305 compound nephron,maturation
R3264 T12305 T12303 pobj maturation,in
R3265 T12306 T12305 cc and,maturation
R3533 T12599 T12596 pobj genes,of
R3535 T12601 T12599 compound signaling,genes
R3536 T12602 T12599 compound target,genes
R3537 T12603 T12595 prep in,expression
R3538 T12604 T12605 det the,kidneys
R3539 T12605 T12603 pobj kidneys,in
R3540 T12606 T12607 compound Pygo1,Pygo2
R3541 T12607 T12609 compound Pygo2,mutant
R3542 T12608 T12607 punct /,Pygo2
R3543 T12609 T12605 compound mutant,kidneys
R3544 T12610 T12588 punct .,indicate
R3545 T12612 T12613 nsubj We,used
R3546 T12614 T12615 amod quantitative,PCR
R3547 T12615 T12613 dobj PCR,used
R3548 T12616 T12617 amod real,time
R3549 T12617 T12615 compound time,PCR
R3550 T12618 T12617 punct -,time
R3551 T12619 T12615 punct ", ",PCR
R3552 T12620 T12615 prep with,PCR
R3553 T12621 T12622 amod independent,samples
R3554 T12622 T12620 pobj samples,with
R3555 T12623 T12622 amod biological,samples
R3556 T12624 T12613 punct ", ",used
R3557 T12625 T12626 aux to,validate
R3558 T12626 T12613 advcl validate,used
R3559 T12627 T12628 det the,results
R3560 T12628 T12626 dobj results,validate
R3561 T12629 T12628 compound microarray,results
R3562 T12630 T12613 punct .,used
R3563 T12632 T12633 nummod Nine,genes
R3564 T12633 T12634 nsubjpass genes,tested
R3565 T12635 T12634 auxpass were,tested
R3566 T12636 T12634 punct ", ",tested
R3567 T12637 T12634 cc and,tested
R3568 T12638 T12639 prep for,observe
R3569 T12639 T12634 conj observe,tested
R3570 T12640 T12638 pobj seven,for
R3571 T12641 T12639 nsubj we,observe
R3572 T12642 T12639 aux did,observe

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T27571 1482-1491 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27570 1461-1467 UBERON:0002113 denotes kidney
T27569 1450-1454 SO_EXT:sequence_nullness denotes null
T27568 1444-1449 PR_EXT:000013524 denotes Pygo2
T27567 1438-1443 PR_EXT:000013523 denotes Pygo1
T27566 1382-1391 GO:0010467 denotes expressed
T27565 1361-1366 SO_EXT:0000704 denotes Genes
T27271 5442-5452 GO:0010467 denotes expression
T27270 5383-5389 CHEBI_SO_EXT:molecular_probe denotes probes
T27269 5377-5382 PR_EXT:000013524 denotes Pygo2
T27268 5367-5372 PR_EXT:000013523 denotes Pygo1
T27267 5312-5322 GO:0010467 denotes expression
T27266 5250-5255 SO_EXT:0000704 denotes genes
T27265 5176-5180 SO_EXT:0000704 denotes gene
T27264 5092-5099 UBERON:0002113 denotes kidneys
T27263 5081-5085 SO_EXT:sequence_nullness denotes null
T27262 5064-5069 PR_EXT:000013523 denotes Pygo1
T27261 5050-5059 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27260 4991-4997 UBERON:0002113 denotes kidney
T27259 4986-4990 SO_EXT:sequence_nullness denotes null
T27258 4980-4985 PR_EXT:000013524 denotes Pygo2
T27257 4974-4979 PR_EXT:000013523 denotes Pygo1
T11977 3648-3654 UBERON:0000479 denotes tissue
T11976 3584-3600 GO_EXT:0008236 denotes serine proteases
T11975 3584-3590 CHEBI_SO_EXT:serine denotes serine
T11974 3571-3578 PR_EXT:000027795 denotes trypsin
T11973 3526-3530 PR_EXT:000009416 denotes Klk6
T11972 3517-3521 PR_EXT:000009415 denotes Klk5
T11971 3496-3504 PR_EXT:000016340 denotes Timeless
T11970 3475-3479 PR_EXT:000014395 denotes Ren2
T11969 3458-3462 PR_EXT:000009416 denotes Klk6
T11968 3441-3445 PR_EXT:000009415 denotes Klk5
T11967 3425-3431 UBERON:0002113 denotes kidney
T11966 3420-3424 SO_EXT:sequence_nullness denotes null
T11965 3414-3419 PR_EXT:000013524 denotes Pygo2
T11964 3408-3413 PR_EXT:000013523 denotes Pygo1
T11963 3389-3400 GO_EXT:positive_regulation denotes upregulated
T11962 3383-3388 SO_EXT:0000704 denotes genes
T11961 1316-1326 GO_PATO_EXT:biological_maturation denotes maturation
T11953 1187-1196 GO:0010467 denotes expressed
T11952 1161-1168 PR_EXT:000015966 denotes Slco1a4
T11951 1148-1159 GO_EXT:biological_mover_or_transporter denotes transporter
T11950 1134-1147 CHEBI:25696 denotes organic anion
T11949 1116-1123 UBERON:0001285 denotes nephron
T11948 1094-1108 GO:0046323 denotes glucose uptake
T11947 1094-1101 CHEBI:17234 denotes glucose
T11946 1051-1056 UBERON:0002113 denotes renal
T11945 1031-1040 GO:0030849 denotes autosomal
T11944 996-1003 UBERON:0001285 denotes nephron
T11943 990-995 UBERON:0007023 denotes adult
T11942 966-982 UBERON:0004134 denotes proximal tubules
T11941 949-958 GO:0010467 denotes expressed
T11940 939-945 PR_EXT:000015169 denotes Slc5a2
T11939 917-924 PR_EXT:000015966 denotes Slco1a4
T11938 892-898 PR_EXT:000015169 denotes Slc5a2
T11937 871-877 PR_EXT:000006067 denotes Cxcl13
T11936 854-861 UBERON:0002113 denotes kidneys
T11935 847-853 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11934 811-816 SO_EXT:0000704 denotes genes
T11933 796-803 UBERON:0002113 denotes kidneys
T11932 789-795 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11931 726-739 GO_EXT:negative_regulation denotes downregulated
T11930 701-706 PR_EXT:000013524 denotes Pygo2
T11929 691-696 PR_EXT:000013523 denotes Pygo1
T11928 513-518 SO_EXT:0000704 denotes genes
T11927 477-487 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T11926 452-459 UBERON:0002113 denotes kidneys
T11925 450-451 SO_EXT:sequence_nullness_or_absence denotes -
T11924 448-449 SO_EXT:sequence_nullness_or_absence denotes -
T11923 443-448 PR_EXT:000013524 denotes Pygo2
T11922 441-442 SO_EXT:sequence_nullness_or_absence denotes -
T11921 439-440 SO_EXT:sequence_nullness_or_absence denotes -
T11920 434-439 PR_EXT:000013523 denotes Pygo1
T11919 420-429 SO_EXT:wild_type_entity_or_quality denotes wild-type
T11918 374-379 SO_EXT:0000704 denotes genes
T11917 348-358 GO:0010467 denotes expression
T11916 299-312 GO:0016055 denotes Wnt signaling
T11915 287-295 SO_EXT:0000167 denotes promoter
T11914 271-279 GO_EXT:reaction_or_response denotes response
T11913 258-266 GO:0065007 denotes monitors
T11912 239-248 SO_EXT:0000902 denotes transgene
T11911 235-238 GO_EXT:0015925 denotes gal
T11910 194-209 GO:0010467 denotes gene expression
T11909 194-198 SO_EXT:0000704 denotes gene
T11908 133-140 UBERON:0002113 denotes kidneys
T11907 126-132 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11906 120-125 PR_EXT:000013524 denotes Pygo2
T11905 114-119 PR_EXT:000013523 denotes Pygo1
T11904 91-106 GO:0010467 denotes gene expression
T11903 91-95 SO_EXT:0000704 denotes gene
T11902 40-47 UBERON:0002113 denotes kidneys
T11901 35-39 SO_EXT:sequence_nullness denotes null
T11900 29-34 PR_EXT:000013524 denotes Pygo2
T11899 23-28 PR_EXT:000013523 denotes Pygo1
T12032 4867-4872 PR_EXT:000013523 denotes Pygo1
T12031 4854-4859 SO_EXT:0000704 denotes genes
T12030 4833-4846 GO:0016055 denotes Wnt signaling
T12029 4802-4812 GO:0010467 denotes expression
T12028 4736-4743 UBERON:0002113 denotes kidneys
T12027 4731-4735 SO_EXT:sequence_nullness denotes null
T12026 4725-4730 PR_EXT:000013524 denotes Pygo2
T12025 4719-4724 PR_EXT:000013523 denotes Pygo1
T12024 4678-4688 GO:0010467 denotes expression
T12023 4634-4639 PR_EXT:000017426 denotes Wisp1
T12022 4614-4623 PR_EXT:000005121 denotes cyclin D1
T12021 4605-4613 SO_EXT:sequence_coding_function denotes encoding
T12020 4599-4604 PR_EXT:000005121 denotes Ccnd1
T12019 4585-4595 GO:0010467 denotes expression
T12018 4556-4563 UBERON:0002113 denotes kidneys
T12017 4549-4555 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T12016 4535-4544 SO_EXT:wild_type_entity_or_quality denotes wild-type
T12015 4516-4526 GO:0010467 denotes expression
T12014 4479-4484 SO_EXT:0000704 denotes genes
T12013 4429-4444 GO_EXT:negative_regulation denotes down regulation
T12012 4364-4369 CHEBI_SO_EXT:molecular_probe denotes probe
T12011 4358-4363 PR_EXT:000013524 denotes Pygo2
T12010 4348-4353 PR_EXT:000013523 denotes Pygo1
T12009 4286-4293 UBERON:0002113 denotes kidneys
T12008 4279-4285 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T12007 4277-4278 SO_EXT:sequence_nullness_or_absence denotes -
T12006 4275-4276 SO_EXT:sequence_nullness_or_absence denotes -
T12005 4270-4275 PR_EXT:000013524 denotes Pygo2
T12004 4268-4269 SO_EXT:sequence_nullness_or_absence denotes -
T12003 4266-4267 SO_EXT:sequence_nullness_or_absence denotes -
T12002 4261-4266 PR_EXT:000013523 denotes Pygo1
T12001 4211-4221 GO:0010467 denotes expression
T12000 4138-4161 GO:0001763 denotes branching morphogenesis
T11999 4129-4137 UBERON:0000056 denotes ureteric
T11998 4120-4128 GO:0065007 denotes regulate
T11997 4082-4095 UBERON:0006364 denotes ureteric tips
T11996 4055-4064 GO:0010467 denotes expressed
T11995 4018-4049 GO:0042752 denotes regulation of circadian rhythms
T11994 3981-4001 GO_EXT:transcription_factor denotes transcription factor
T11993 3981-3994 GO_EXT:transcription denotes transcription
T11992 3969-3977 PR_EXT:000016340 denotes Timeless
T11991 3940-3962 UBERON:0004100 denotes collecting-duct system
T11990 3929-3935 UBERON:0000056 denotes ureter
T11989 3848-3859 CHEBI_PR_EXT:angiotensin denotes angiotensin
T11988 3842-3847 PR_EXT:000013883 denotes renin
T11987 3803-3808 UBERON:0000178 denotes blood
T11986 3772-3783 CHEBI_PR_EXT:angiotensin denotes angiotensin
T11985 3766-3771 PR_EXT:000013883 denotes renin
T11984 3743-3750 PR_EXT:000014394 denotes Renin 1
T11983 3729-3742 GO_EXT:0004175 denotes endopeptidase
T11982 3714-3721 SO_EXT:0000853 denotes homolog
T11981 3706-3710 PR_EXT:000014395 denotes Ren2
T11980 3685-3690 UBERON:0000178 denotes blood
T11979 3671-3699 GO:0008217 denotes regulation of blood pressure
T11978 3648-3665 GO:0048771 denotes tissue remodeling
T27256 4939-4952 GO:0016055 denotes Wnt signaling
T27255 4905-4920 GO:0010467 denotes Gene expression
T27254 4905-4909 SO_EXT:0000704 denotes Gene
T27253 5265-5275 GO:0010467 denotes expression
T27654 5986-5993 UBERON:0002113 denotes kidneys
T27653 5976-5985 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27652 5948-5955 UBERON:0002113 denotes kidneys
T27651 5943-5947 SO_EXT:sequence_nullness denotes null
T27650 5937-5942 PR_EXT:000013524 denotes Pygo2
T27649 5931-5936 PR_EXT:000013523 denotes Pygo1
T27648 5894-5909 GO:0010467 denotes gene expression
T27647 5894-5898 SO_EXT:0000704 denotes gene
T11955 1225-1231 UBERON:0009773 denotes kidney
T11954 1204-1214 _FRAGMENT denotes tubules of
T11960 1308-1315 UBERON:0001285 denotes nephron
T11959 1281-1286 SO_EXT:0000704 denotes genes
T11958 1275-1280 PR_EXT:000013524 denotes Pygo2
T11957 1269-1274 PR_EXT:000013523 denotes Pygo1
T11956 1219-1224 UBERON:0007023 denotes adult
T12038 5760-5765 SO_EXT:0000704 denotes genes
T12037 5575-5580 SO_EXT:0000704 denotes genes
T12036 5514-5524 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T12035 4886-4893 UBERON:0002113 denotes kidneys
T12034 4879-4885 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T12033 4873-4878 PR_EXT:000013524 denotes Pygo2
R3016 T11955 T11954 _lexicallyChainedTo kidney,tubules of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T27241 4974-4979 PR:000013523 denotes Pygo1
T27240 4939-4952 GO:0016055 denotes Wnt signaling
T27239 4905-4920 GO:0010467 denotes Gene expression
T27238 4905-4909 SO:0000704 denotes Gene
T27564 1461-1467 UBERON:0002113 denotes kidney
T27563 1444-1449 PR:000013524 denotes Pygo2
T27562 1438-1443 PR:000013523 denotes Pygo1
T11898 5760-5765 SO:0000704 denotes genes
T11897 5575-5580 SO:0000704 denotes genes
T11896 4886-4893 UBERON:0002113 denotes kidneys
T11895 4873-4878 PR:000013524 denotes Pygo2
T11894 4867-4872 PR:000013523 denotes Pygo1
T11893 4854-4859 SO:0000704 denotes genes
T11892 4833-4846 GO:0016055 denotes Wnt signaling
T11891 4802-4812 GO:0010467 denotes expression
T11890 4736-4743 UBERON:0002113 denotes kidneys
T11889 4725-4730 PR:000013524 denotes Pygo2
T11888 4719-4724 PR:000013523 denotes Pygo1
T11887 4678-4688 GO:0010467 denotes expression
T11886 4634-4639 PR:000017426 denotes Wisp1
T11885 4614-4623 PR:000005121 denotes cyclin D1
T11884 4599-4604 PR:000005121 denotes Ccnd1
T11883 4585-4595 GO:0010467 denotes expression
T11882 4556-4563 UBERON:0002113 denotes kidneys
T11881 4516-4526 GO:0010467 denotes expression
T11880 4479-4484 SO:0000704 denotes genes
T11879 4358-4363 PR:000013524 denotes Pygo2
T11878 4348-4353 PR:000013523 denotes Pygo1
T11877 4286-4293 UBERON:0002113 denotes kidneys
T11876 4270-4275 PR:000013524 denotes Pygo2
T11875 4261-4266 PR:000013523 denotes Pygo1
T11874 4211-4221 GO:0010467 denotes expression
T11873 4138-4161 GO:0001763 denotes branching morphogenesis
T11872 4129-4137 UBERON:0000056 denotes ureteric
T11871 4120-4128 GO:0065007 denotes regulate
T11870 4082-4095 UBERON:0006364 denotes ureteric tips
T11869 4055-4064 GO:0010467 denotes expressed
T11868 4018-4049 GO:0042752 denotes regulation of circadian rhythms
T11867 3969-3977 PR:000016340 denotes Timeless
T11866 3940-3962 UBERON:0004100 denotes collecting-duct system
T11865 3929-3935 UBERON:0000056 denotes ureter
T11864 3842-3847 PR:000013883 denotes renin
T11863 3803-3808 UBERON:0000178 denotes blood
T11862 3766-3771 PR:000013883 denotes renin
T11861 3743-3750 PR:000014394 denotes Renin 1
T11860 3714-3721 SO:0000853 denotes homolog
T11859 3706-3710 PR:000014395 denotes Ren2
T11858 3685-3690 UBERON:0000178 denotes blood
T11857 3671-3699 GO:0008217 denotes regulation of blood pressure
T11856 3648-3665 GO:0048771 denotes tissue remodeling
T11855 3648-3654 UBERON:0000479 denotes tissue
T11854 3571-3578 PR:000027795 denotes trypsin
T11853 3526-3530 PR:000009416 denotes Klk6
T11852 3517-3521 PR:000009415 denotes Klk5
T11851 3496-3504 PR:000016340 denotes Timeless
T11850 3475-3479 PR:000014395 denotes Ren2
T11849 3458-3462 PR:000009416 denotes Klk6
T11848 3441-3445 PR:000009415 denotes Klk5
T11847 3425-3431 UBERON:0002113 denotes kidney
T11846 3414-3419 PR:000013524 denotes Pygo2
T11845 3408-3413 PR:000013523 denotes Pygo1
T11844 3383-3388 SO:0000704 denotes genes
T11843 1308-1315 UBERON:0001285 denotes nephron
T11842 1281-1286 SO:0000704 denotes genes
T11841 1275-1280 PR:000013524 denotes Pygo2
T11840 1269-1274 PR:000013523 denotes Pygo1
T11839 1219-1224 UBERON:0007023 denotes adult
T11838 1225-1231 UBERON:0009773 denotes kidney
T11837 1204-1214 _FRAGMENT denotes tubules of
T11836 1187-1196 GO:0010467 denotes expressed
T11835 1161-1168 PR:000015966 denotes Slco1a4
T11834 1134-1147 CHEBI:25696 denotes organic anion
T11833 1116-1123 UBERON:0001285 denotes nephron
T11832 1094-1108 GO:0046323 denotes glucose uptake
T11831 1094-1101 CHEBI:17234 denotes glucose
T11830 1051-1056 UBERON:0002113 denotes renal
T11829 1031-1040 GO:0030849 denotes autosomal
T11817 701-706 PR:000013524 denotes Pygo2
T11816 691-696 PR:000013523 denotes Pygo1
T11815 513-518 SO:0000704 denotes genes
T11814 452-459 UBERON:0002113 denotes kidneys
T11813 443-448 PR:000013524 denotes Pygo2
T11812 434-439 PR:000013523 denotes Pygo1
T11811 374-379 SO:0000704 denotes genes
T11810 348-358 GO:0010467 denotes expression
T11809 299-312 GO:0016055 denotes Wnt signaling
T11808 287-295 SO:0000167 denotes promoter
T11807 258-266 GO:0065007 denotes monitors
T11806 239-248 SO:0000902 denotes transgene
T11805 194-209 GO:0010467 denotes gene expression
T11804 194-198 SO:0000704 denotes gene
T11803 133-140 UBERON:0002113 denotes kidneys
T11802 120-125 PR:000013524 denotes Pygo2
T11801 114-119 PR:000013523 denotes Pygo1
T11800 91-106 GO:0010467 denotes gene expression
T11799 91-95 SO:0000704 denotes gene
T11798 40-47 UBERON:0002113 denotes kidneys
T11797 29-34 PR:000013524 denotes Pygo2
T11796 23-28 PR:000013523 denotes Pygo1
T27646 5986-5993 UBERON:0002113 denotes kidneys
T27645 5948-5955 UBERON:0002113 denotes kidneys
T27644 5937-5942 PR:000013524 denotes Pygo2
T27643 5931-5936 PR:000013523 denotes Pygo1
T27642 5894-5909 GO:0010467 denotes gene expression
T27641 5894-5898 SO:0000704 denotes gene
T27252 5442-5452 GO:0010467 denotes expression
T27251 5377-5382 PR:000013524 denotes Pygo2
T27250 5367-5372 PR:000013523 denotes Pygo1
T27249 5312-5322 GO:0010467 denotes expression
T27248 5265-5275 GO:0010467 denotes expression
T27247 5250-5255 SO:0000704 denotes genes
T27246 5176-5180 SO:0000704 denotes gene
T27245 5092-5099 UBERON:0002113 denotes kidneys
T27244 5064-5069 PR:000013523 denotes Pygo1
T27243 4991-4997 UBERON:0002113 denotes kidney
T27242 4980-4985 PR:000013524 denotes Pygo2
T27561 1382-1391 GO:0010467 denotes expressed
T27560 1361-1366 SO:0000704 denotes Genes
T11828 996-1003 UBERON:0001285 denotes nephron
T11827 990-995 UBERON:0007023 denotes adult
T11826 966-982 UBERON:0004134 denotes proximal tubules
T11825 949-958 GO:0010467 denotes expressed
T11824 939-945 PR:000015169 denotes Slc5a2
T11823 917-924 PR:000015966 denotes Slco1a4
T11822 892-898 PR:000015169 denotes Slc5a2
T11821 871-877 PR:000006067 denotes Cxcl13
T11820 854-861 UBERON:0002113 denotes kidneys
T11819 811-816 SO:0000704 denotes genes
T11818 796-803 UBERON:0002113 denotes kidneys
R3015 T11838 T11837 _lexicallyChainedTo kidney,tubules of

2_test

Id Subject Object Predicate Lexical cue
17425782-12436245-8469464 1125-1127 12436245 denotes 23
17425782-12101011-8469465 1233-1235 12101011 denotes 24
17425782-15192120-8469466 3701-3703 15192120 denotes 25
17425782-12512695-8469467 3819-3821 12512695 denotes 26
17425782-16601496-8469468 3964-3966 16601496 denotes 27
17425782-10963667-8469469 4163-4165 10963667 denotes 28
17425782-10318916-8469470 4625-4627 10318916 denotes 29
17425782-10716946-8469471 4641-4643 10716946 denotes 30