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Id Subject Object Predicate Lexical cue
T16127 34422-34428 NN denotes mutant
T27371 29025-29036 VB denotes demonstrate
T27370 29022-29024 TO denotes to
T27369 29008-29012 VBD denotes were
T27368 29013-29021 VBN denotes included
T27367 28995-29000 NN denotes Pygo2
T27366 28991-28994 CC denotes and
T27365 29001-29007 NNS denotes probes
T27364 28985-28990 NN denotes Pygo1
T27363 28984-29078 sentence denotes Pygo1 and Pygo2 probes were included to demonstrate significant changes in expression levels.
T27362 28983-28984 . denotes .
T27361 28976-28983 NNS denotes samples
T27360 28968-28973 RBS denotes least
T27359 28974-28975 CD denotes 3
T27358 28965-28967 RB denotes at
T27357 28962-28964 IN denotes in
T27356 28958-28961 CD denotes 100
T27355 28957-28958 SYM denotes >
T27354 28954-28956 VB denotes be
T27353 28951-28953 TO denotes to
T27352 28930-28940 NN denotes expression
T27351 28926-28929 JJ denotes raw
T27350 28941-28950 NN denotes intensity
T27349 28922-28925 DT denotes the
T27348 28912-28921 VBG denotes requiring
T27347 28894-28899 NN denotes level
T27346 28883-28893 NN denotes expression
T27345 28900-28911 NN denotes restriction
T27344 28880-28882 DT denotes an
T27343 28874-28879 VBG denotes using
T27342 28868-28873 NNS denotes genes
T27341 28865-28867 CD denotes 40
T27340 28862-28864 IN denotes of
T27339 28856-28861 NN denotes total
T27338 28854-28855 DT denotes a
T27337 28851-28853 IN denotes to
T27336 28843-28850 VBN denotes reduced
T27335 28838-28842 RB denotes then
T27334 28834-28837 CC denotes and
T27333 28822-28825 VBD denotes was
T27332 28810-28813 NN denotes Wnt
T27331 28814-28821 NNS denotes targets
T27330 28807-28809 CD denotes 82
T27329 28804-28806 IN denotes of
T27328 28826-28833 VBN denotes created
T27327 28794-28798 NN denotes gene
T27326 28786-28793 JJ denotes initial
T27325 28799-28803 NN denotes list
T27324 28783-28785 DT denotes An
T27323 28782-28984 sentence denotes An initial gene list of 82 Wnt targets was created and then reduced to a total of 40 genes using an expression level restriction requiring the raw expression intensity to be >100 in at least 3 samples.
T27322 28781-28782 . denotes .
T27321 28780-28781 -RRB- denotes ]
T27320 28778-28780 CD denotes 39
T27319 28777-28778 -LRB- denotes [
T27318 28774-28776 IN denotes at
T27317 28765-28773 VBN denotes compiled
T27316 28759-28764 DT denotes those
T27589 25062-25067 NN denotes Pygo2
T27588 25056-25061 NN denotes Pygo1
T27587 25079-25085 NN denotes kidney
T27586 25052-25055 DT denotes the
T27585 25049-25051 IN denotes in
T27584 25047-25048 -RRB- denotes )
T27583 25040-25047 JJR denotes greater
T27582 25037-25039 CC denotes or
T27581 25021-25029 JJ denotes two-fold
T27580 25019-25021 , denotes ,
T27579 25013-25014 SYM denotes <
T27578 25015-25019 CD denotes 0.05
T27577 25011-25012 NN denotes p
T27576 25030-25036 NN denotes change
T27575 25010-25011 -LRB- denotes (
T27574 25000-25009 VBN denotes expressed
T27573 24985-24999 RB denotes differentially
T27572 24979-24984 NNS denotes Genes
T26928 21778-21779 HYPH denotes /
T26927 21779-21784 NN denotes Pygo2
T26926 21773-21778 NN denotes Pygo1
T26925 21770-21772 IN denotes in
T26924 21759-21769 NN denotes expression
T26923 21750-21758 NN denotes reporter
T26922 21745-21746 HYPH denotes -
T26921 21746-21749 NN denotes gal
T26920 21742-21745 NN denotes BAT
T26919 21739-21741 IN denotes of
T26918 21730-21738 NN denotes analysis
T26917 21717-21729 JJ denotes Quantitative
T27310 28719-28727 JJ denotes Possible
T27309 28718-28782 sentence denotes Possible Wnt targets were selected from those compiled at [39].
T27308 28717-28718 . denotes .
T27307 28704-28709 NN denotes E18.5
T27306 28690-28698 NN denotes compound
T27305 28688-28689 CD denotes 2
T27304 28687-28688 HYPH denotes /
T27303 28699-28703 JJ denotes null
T27302 28682-28687 NN denotes Pygo1
T27301 28678-28681 CC denotes and
T27300 28710-28717 NNS denotes kidneys
T27299 28672-28673 HYPH denotes -
T27298 28673-28677 NN denotes type
T27297 28668-28672 JJ denotes wild
T27296 28665-28667 IN denotes on
T27295 28654-28664 NN denotes triplicate
T27294 28651-28653 IN denotes in
T27293 28637-28640 VBD denotes was
T27292 28641-28650 VBN denotes performed
T27291 28628-28636 NN denotes analysis
T27290 28617-28627 NN denotes Microarray
T27289 28616-28718 sentence denotes Microarray analysis was performed in triplicate on wild-type and Pygo1/2 compound null E18.5 kidneys.
T27288 28615-28616 . denotes .
T27287 28604-28608 JJ denotes null
T27286 28597-28598 HYPH denotes /
T27285 28598-28603 NN denotes Pygo2
T27284 28592-28597 NN denotes Pygo1
T27283 28586-28591 NN denotes E18.5
T27282 28609-28615 NN denotes kidney
T27281 28582-28585 DT denotes the
T27280 28579-28581 IN denotes in
T27279 28561-28570 NN denotes signaling
T27278 28557-28560 NN denotes Wnt
T27277 28571-28578 NNS denotes targets
T27276 28550-28556 JJ denotes common
T27275 28547-28549 IN denotes of
T27274 28539-28546 NNS denotes changes
T27273 28528-28538 NN denotes expression
T27272 28523-28527 NN denotes Gene
T27007 22103-22104 . denotes .
T27006 22102-22103 NN denotes %
T27005 22100-22102 CD denotes 50
T27004 22094-22099 IN denotes about
T27003 22091-22093 IN denotes by
T27002 22079-22082 VBD denotes was
T27001 22068-22078 NN denotes expression
T27000 22059-22067 NN denotes reporter
T26999 22057-22059 , denotes ,
T26998 22050-22057 RB denotes however
T26997 22048-22050 , denotes ,
T26996 22030-22040 JJ denotes homozygous
T26995 22024-22029 NN denotes Pygo1
T26994 22022-22024 , denotes ,
T26993 22009-22022 NN denotes hetereozygote
T26992 22003-22008 NN denotes Pygo2
T26991 22041-22048 NNS denotes mutants
T26990 21999-22002 DT denotes the
T26989 22083-22090 VBN denotes reduced
T26988 21996-21998 IN denotes In
T26987 21995-22104 sentence denotes In the Pygo2 hetereozygote, Pygo1 homozygous mutants, however, reporter expression was reduced by about 50%.
T26986 21994-21995 . denotes .
T26985 21984-21994 NN denotes expression
T26984 21979-21980 HYPH denotes -
T26983 21980-21983 NN denotes gal
T26982 21976-21979 NN denotes BAT
T26981 21973-21975 IN denotes of
T26980 21966-21972 NNS denotes levels
T26979 21958-21965 JJ denotes similar
T26978 21947-21950 RB denotes all
T26977 21951-21957 VBD denotes showed
T26976 21937-21938 SYM denotes +
T26975 21936-21937 HYPH denotes /
T26974 21935-21936 SYM denotes +
T26973 21930-21935 NN denotes Pygo2
T26972 21929-21930 HYPH denotes /
T26971 21928-21929 SYM denotes -
T26970 21927-21928 HYPH denotes /
T26969 21926-21927 SYM denotes +
T26968 21921-21926 NN denotes Pygo1
T26967 21917-21920 CC denotes and
T26966 21915-21916 SYM denotes -
T26965 21914-21915 HYPH denotes /
T26964 21913-21914 SYM denotes +
T26963 21908-21913 NN denotes Pygo2
T26962 21907-21908 HYPH denotes /
T26961 21906-21907 SYM denotes -
T26960 21905-21906 HYPH denotes /
T26959 21904-21905 SYM denotes +
T26958 21899-21904 NN denotes Pygo1
T26957 21897-21899 , denotes ,
T26956 21896-21897 SYM denotes +
T26955 21895-21896 HYPH denotes /
T26954 21894-21895 SYM denotes +
T26953 21889-21894 NN denotes Pygo2
T26952 21888-21889 HYPH denotes /
T26951 21887-21888 SYM denotes -
T26950 21886-21887 HYPH denotes /
T26949 21885-21886 SYM denotes +
T26948 21939-21946 NNS denotes kidneys
T26947 21880-21885 NN denotes Pygo1
T26946 21879-21995 sentence denotes Pygo1+/-/Pygo2+/+, Pygo1+/-/Pygo2+/- and Pygo1+/-/Pygo2+/+ kidneys all showed similar levels of BAT-gal expression.
T26945 21878-21879 . denotes .
T26944 21870-21878 NN denotes analysis
T26943 21864-21869 NNP denotes ELISA
T26942 21861-21863 IN denotes by
T26941 21846-21849 VBD denotes was
T26940 21850-21860 VBN denotes quantified
T26939 21831-21832 HYPH denotes -
T26938 21827-21831 NN denotes beta
T26937 21832-21845 NN denotes galactosidase
T26936 21817-21818 HYPH denotes -
T26935 21818-21826 JJ denotes specific
T26934 21808-21817 NN denotes Transgene
T26933 21807-21879 sentence denotes Transgene-specific beta-galactosidase was quantified by ELISA analysis.
T26932 21806-21807 . denotes .
T26931 21791-21797 NN denotes kidney
T26930 21785-21790 NN denotes E18.5
T26929 21798-21806 NNS denotes extracts
T26615 18481-18482 -RRB- denotes )
T26614 18480-18481 NN denotes L
T26613 18479-18480 SYM denotes -
T26612 18485-18487 CD denotes 50
T26611 18478-18479 NN denotes J
T26610 18477-18478 -LRB- denotes (
T26609 18475-18477 , denotes ,
T26608 18471-18472 SYM denotes ×
T26607 18469-18470 -RRB- denotes )
T26606 18468-18469 NN denotes I
T26605 18467-18468 SYM denotes -
T26604 18473-18475 CD denotes 40
T26603 18466-18467 NN denotes G
T26602 18465-18466 -LRB- denotes (
T26601 18463-18465 , denotes ,
T26600 18459-18460 SYM denotes ×
T26599 18457-18458 -RRB- denotes )
T26598 18456-18457 NN denotes F
T26597 18455-18456 SYM denotes -
T26596 18461-18463 CD denotes 63
T26595 18454-18455 NN denotes D
T26594 18453-18454 -LRB- denotes (
T26593 18451-18453 , denotes ,
T26592 18447-18448 SYM denotes ×
T26591 18445-18446 -RRB- denotes )
T26590 18444-18445 NN denotes C
T26589 18443-18444 SYM denotes -
T26588 18442-18443 NN denotes A
T26587 18441-18442 -LRB- denotes (
T26586 18439-18441 : denotes :
T26585 18449-18451 CD denotes 32
T26584 18426-18439 NN denotes magnification
T26583 18417-18425 JJ denotes Original
T26582 18416-18517 sentence denotes Original magnification: (A-C) × 32, (D-F) × 63, (G-I) × 40, (J-L) × 50, (M, N) × 10, and (O) × 12.5.
T26581 18415-18416 . denotes .
T26580 18407-18408 -RRB- denotes )
T26579 18402-18407 JJ denotes right
T26578 18401-18402 -LRB- denotes (
T26577 18399-18400 SYM denotes -
T26576 18398-18399 HYPH denotes /
T26575 18397-18398 SYM denotes -
T26574 18392-18397 NN denotes Pygo2
T26573 18391-18392 HYPH denotes /
T26572 18390-18391 SYM denotes -
T26571 18389-18390 HYPH denotes /
T26570 18388-18389 SYM denotes -
T26569 18383-18388 NN denotes Pygo1
T26568 18409-18415 NN denotes kidney
T26567 18379-18382 DT denotes the
T26566 18376-18378 IN denotes in
T26565 18371-18375 JJ denotes lost
T26564 18367-18370 CC denotes but
T26563 18365-18367 , denotes ,
T26562 18356-18357 -RRB- denotes )
T26561 18350-18356 JJ denotes middle
T26560 18349-18350 -LRB- denotes (
T26559 18347-18348 SYM denotes -
T26558 18346-18347 HYPH denotes /
T26557 18345-18346 SYM denotes +
T26556 18340-18345 NN denotes Pygo2
T26555 18339-18340 HYPH denotes /
T26554 18338-18339 SYM denotes -
T26553 18337-18338 HYPH denotes /
T26552 18336-18337 SYM denotes -
T26551 18331-18336 NN denotes Pygo1
T26550 18327-18330 CC denotes and
T26549 18325-18326 -RRB- denotes )
T26548 18321-18325 JJ denotes left
T26547 18320-18321 -LRB- denotes (
T26546 18318-18319 SYM denotes +
T26545 18317-18318 HYPH denotes /
T26544 18316-18317 SYM denotes +
T26543 18311-18316 NN denotes Pygo2
T26542 18310-18311 HYPH denotes /
T26541 18309-18310 SYM denotes -
T26540 18308-18309 HYPH denotes /
T26539 18307-18308 SYM denotes +
T26538 18302-18307 NN denotes Pygo1
T26537 18358-18365 NNS denotes kidneys
T26536 18298-18301 DT denotes the
T26535 18295-18297 IN denotes of
T26534 18273-18281 JJ denotes ureteric
T26533 18282-18294 NNS denotes compartments
T26532 18269-18272 DT denotes the
T26531 18266-18268 IN denotes in
T26530 18258-18265 JJ denotes present
T26529 18254-18257 VBD denotes was
T26528 18245-18253 NN denotes activity
T26527 18236-18244 NN denotes Reporter
T26526 18235-18416 sentence denotes Reporter activity was present in the ureteric compartments of the Pygo1+/-/Pygo2+/+ (left) and Pygo1-/-/Pygo2+/- (middle) kidneys, but lost in the Pygo1-/-/Pygo2-/- (right) kidney.
T26525 18234-18235 . denotes .
T26524 18221-18226 NN denotes E18.5
T26523 18219-18220 -RRB- denotes )
T26522 18214-18219 JJ denotes right
T26521 18213-18214 -LRB- denotes (
T26520 18211-18212 SYM denotes -
T26519 18210-18211 HYPH denotes /
T26518 18209-18210 SYM denotes -
T26517 18204-18209 NN denotes Pygo2
T26516 18203-18204 HYPH denotes /
T26515 18202-18203 SYM denotes -
T26514 18201-18202 HYPH denotes /
T26513 18200-18201 SYM denotes -
T26512 18195-18200 NN denotes Pygo1
T26511 18191-18194 CC denotes and
T26510 18189-18191 , denotes ,
T26509 18188-18189 -RRB- denotes )
T26508 18182-18188 JJ denotes middle
T26507 18181-18182 -LRB- denotes (
T26506 18179-18180 SYM denotes -
T26505 18178-18179 HYPH denotes /
T26504 18177-18178 SYM denotes +
T26503 18172-18177 NN denotes Pygo2
T26502 18171-18172 HYPH denotes /
T26501 18170-18171 SYM denotes -
T26500 18169-18170 HYPH denotes /
T26499 18168-18169 SYM denotes -
T26498 18163-18168 NN denotes Pygo1
T26497 18161-18163 , denotes ,
T26496 18160-18161 -RRB- denotes )
T26495 18156-18160 JJ denotes left
T26494 18155-18156 -LRB- denotes (
T26493 18153-18154 SYM denotes +
T26492 18152-18153 HYPH denotes /
T26491 18151-18152 SYM denotes +
T26490 18146-18151 NN denotes Pygo2
T26489 18145-18146 HYPH denotes /
T26488 18144-18145 SYM denotes -
T26487 18143-18144 HYPH denotes /
T26486 18142-18143 SYM denotes +
T26485 18137-18142 NN denotes Pygo1
T26484 18135-18136 -RRB- denotes )
T26483 18227-18234 NNS denotes kidneys
T26482 18134-18135 LS denotes O
T26481 18133-18134 -LRB- denotes (
T26480 18132-18235 sentence denotes (O) Pygo1+/-/Pygo2+/+ (left), Pygo1-/-/Pygo2+/- (middle), and Pygo1-/-/Pygo2-/- (right) E18.5 kidneys.
T26479 18131-18132 . denotes .
T26478 18112-18113 HYPH denotes -
T26477 18113-18123 JJ denotes homozygous
T26476 18106-18112 JJ denotes double
T26475 18124-18131 NNS denotes mutants
T26474 18102-18105 DT denotes the
T26473 18099-18101 IN denotes in
T26472 18083-18093 RB denotes completely
T26471 18076-18082 RB denotes almost
T26470 18094-18098 VBN denotes lost
T26469 18072-18075 VBD denotes was
T26468 18068-18071 CC denotes but
T26467 18047-18053 JJ denotes double
T26466 18054-18067 NNS denotes heterozygotes
T26465 18043-18046 DT denotes the
T26464 18040-18042 IN denotes of
T26463 18032-18039 NN denotes medulla
T26462 18028-18031 CC denotes and
T26461 18021-18027 NN denotes cortex
T26460 18017-18020 DT denotes the
T26459 18014-18016 IN denotes of
T26458 17998-18002 NN denotes tree
T26457 17989-17997 JJ denotes ureteric
T26456 18003-18013 NNS denotes components
T26455 17985-17988 DT denotes the
T26454 17982-17984 IN denotes in
T26453 17973-17976 VBD denotes was
T26452 17977-17981 VBN denotes seen
T26451 17962-17972 NN denotes expression
T26450 17953-17961 NN denotes reporter
T26449 17948-17949 HYPH denotes -
T26448 17949-17952 NN denotes gal
T26447 17945-17948 NN denotes BAT
T26446 17944-18132 sentence denotes BAT-gal reporter expression was seen in the ureteric tree components of the cortex and medulla of the double heterozygotes but was almost completely lost in the double-homozygous mutants.
T26294 17402-17404 , denotes ,
T26293 17401-17402 -RRB- denotes )
T26292 17386-17391 JJ denotes white
T26291 17392-17401 NN denotes arrowhead
T26290 17385-17386 -LRB- denotes (
T26289 17364-17379 JJ denotes paramesonephric
T26288 17380-17384 NN denotes duct
T26287 17360-17363 DT denotes the
T26286 17357-17359 IN denotes in
T26285 17346-17356 NN denotes expression
T26284 17337-17345 NN denotes reporter
T26283 17329-17336 VBG denotes showing
T26282 17316-17323 JJ denotes ventral
T26281 17314-17315 -RRB- denotes )
T26280 17324-17328 NN denotes view
T26279 17313-17314 LS denotes H
T26278 17312-17313 -LRB- denotes (
T26277 17307-17311 IN denotes with
T26276 17305-17307 , denotes ,
T26275 17304-17305 SYM denotes -
T26274 17303-17304 HYPH denotes /
T26273 17302-17303 SYM denotes +
T26272 17297-17302 NN denotes Pygo2
T26271 17296-17297 HYPH denotes /
T26270 17295-17296 SYM denotes -
T26269 17294-17295 HYPH denotes /
T26268 17293-17294 SYM denotes -
T26267 17286-17287 -RRB- denotes )
T26266 17285-17286 LS denotes I
T26265 17283-17285 , denotes ,
T26264 17288-17293 NN denotes Pygo1
T26263 17282-17283 LS denotes H
T26262 17281-17282 -LRB- denotes (
T26261 17280-17471 sentence denotes (H, I) Pygo1-/-/Pygo2+/-, with (H) ventral view showing reporter expression in the paramesonephric duct (white arrowhead), and (I) dorsal view showing ureteric tree expression in the kidney.
T26260 17279-17280 . denotes .
T26259 17275-17279 NN denotes tree
T26258 17266-17274 JJ denotes ureteric
T26257 17262-17265 CC denotes and
T26256 17260-17261 -RRB- denotes )
T26255 17245-17250 JJ denotes white
T26254 17251-17260 NN denotes arrowhead
T26253 17244-17245 -LRB- denotes (
T26252 17223-17238 JJ denotes paramesonephric
T26251 17239-17243 NN denotes duct
T26250 17219-17222 DT denotes the
T26249 17216-17218 IN denotes in
T26248 17205-17215 NN denotes expression
T26247 17196-17204 NN denotes reporter
T26246 17191-17195 IN denotes with
T26245 17189-17191 , denotes ,
T26244 17188-17189 SYM denotes -
T26243 17187-17188 HYPH denotes /
T26242 17186-17187 SYM denotes +
T26241 17181-17186 NN denotes Pygo2
T26240 17180-17181 HYPH denotes /
T26239 17179-17180 SYM denotes -
T26238 17178-17179 HYPH denotes /
T26237 17177-17178 SYM denotes +
T26236 17170-17171 -RRB- denotes )
T26235 17172-17177 NN denotes Pygo1
T26234 17169-17170 LS denotes G
T26233 17168-17169 -LRB- denotes (
T26232 17167-17280 sentence denotes (G) Pygo1+/-/Pygo2+/-, with reporter expression in the paramesonephric duct (white arrowhead) and ureteric tree.
T26231 17166-17167 . denotes .
T26230 17146-17154 JJ denotes ureteric
T26229 17155-17166 NN denotes compartment
T26228 17142-17145 DT denotes the
T26227 17139-17141 IN denotes in
T26226 17130-17138 NN denotes activity
T26225 17121-17129 NN denotes reporter
T26224 17116-17117 HYPH denotes -
T26223 17117-17120 NN denotes gal
T26222 17113-17116 NN denotes BAT
T26221 17110-17112 IN denotes of
T26220 17100-17109 NN denotes reduction
T26219 17093-17099 JJ denotes marked
T26218 17088-17092 IN denotes with
T26217 17086-17088 , denotes ,
T26216 17085-17086 SYM denotes -
T26215 17084-17085 HYPH denotes /
T26214 17083-17084 SYM denotes -
T26213 17078-17083 NN denotes Pygo2
T26212 17077-17078 HYPH denotes /
T26211 17076-17077 SYM denotes -
T26210 17075-17076 HYPH denotes /
T26209 17074-17075 SYM denotes +
T26208 17067-17068 -RRB- denotes )
T26207 17069-17074 NN denotes Pygo1
T26206 17066-17067 LS denotes F
T26205 17065-17066 -LRB- denotes (
T26204 17064-17167 sentence denotes (F) Pygo1+/-/Pygo2-/-, with marked reduction of BAT-gal reporter activity in the ureteric compartment.
T26203 17063-17064 . denotes .
T26202 17057-17063 NN denotes ureter
T26201 17053-17056 CC denotes and
T26200 17051-17053 , denotes ,
T26199 17047-17051 NN denotes tree
T26198 17038-17046 JJ denotes ureteric
T26197 17036-17038 , denotes ,
T26196 17023-17031 JJ denotes ureteric
T26195 17032-17036 NNS denotes tips
T26194 17019-17022 DT denotes the
T26193 17009-17018 VBG denotes including
T26192 17007-17009 , denotes ,
T26191 16990-17000 VBG denotes developing
T26190 17001-17007 NN denotes kidney
T26189 16986-16989 DT denotes the
T26188 16983-16985 IN denotes of
T26187 16962-16970 JJ denotes ureteric
T26186 16971-16982 NN denotes compartment
T26185 16958-16961 DT denotes the
T26184 16955-16957 IN denotes in
T26183 16946-16954 NN denotes activity
T26182 16937-16945 NN denotes reporter
T26181 16932-16933 HYPH denotes -
T26180 16933-16936 NN denotes gal
T26179 16929-16932 NN denotes BAT
T26178 16924-16928 IN denotes with
T26177 16922-16924 , denotes ,
T26176 16921-16922 SYM denotes +
T26175 16920-16921 HYPH denotes /
T26174 16919-16920 SYM denotes +
T26173 16914-16919 NN denotes Pygo2
T26172 16913-16914 HYPH denotes /
T26171 16912-16913 SYM denotes -
T26170 16911-16912 HYPH denotes /
T26169 16910-16911 SYM denotes +
T26168 16903-16904 -RRB- denotes )
T26167 16905-16910 NN denotes Pygo1
T26166 16902-16903 LS denotes E
T26165 16901-16902 -LRB- denotes (
T26164 16900-17064 sentence denotes (E) Pygo1+/-/Pygo2+/+, with BAT-gal reporter activity in the ureteric compartment of the developing kidney, including the ureteric tips, ureteric tree, and ureter.
T26163 16899-16900 . denotes .
T26162 16876-16877 HYPH denotes -
T26161 16877-16890 NN denotes galactosidase
T26160 16872-16876 NN denotes beta
T26159 16891-16899 NN denotes activity
T26158 16861-16871 JJ denotes endogenous
T26157 16858-16860 IN denotes of
T26156 16850-16857 NN denotes absence
T26155 16842-16849 VBG denotes showing
T26154 16840-16842 , denotes ,
T26153 16839-16840 -RRB- denotes )
T26152 16833-16839 NN denotes Non-Tg
T26151 16832-16833 -LRB- denotes (
T26150 16817-16818 HYPH denotes -
T26149 16818-16821 NN denotes gal
T26148 16814-16817 NN denotes BAT
T26147 16822-16831 NN denotes transgene
T26146 16810-16813 DT denotes the
T26145 16802-16809 IN denotes without
T26144 16789-16794 NN denotes E13.5
T26143 16795-16801 NN denotes embryo
T26142 16786-16788 DT denotes an
T26141 16781-16785 IN denotes from
T26140 16764-16774 JJ denotes urogenital
T26139 16775-16780 NN denotes tract
T26138 16762-16763 DT denotes a
T26137 16759-16761 IN denotes of
T26136 16745-16746 HYPH denotes -
T26135 16746-16749 NN denotes gal
T26134 16744-16745 NN denotes X
T26133 16733-16743 NN denotes background
T26132 16725-16732 NN denotes Control
T26131 16723-16724 -RRB- denotes )
T26130 16750-16758 NN denotes staining
T26129 16722-16723 LS denotes D
T26128 16721-16722 -LRB- denotes (
T26127 16720-16900 sentence denotes (D) Control background X-gal staining of a urogenital tract from an E13.5 embryo without the BAT-gal transgene (Non-Tg), showing absence of endogenous beta-galactosidase activity.
T26126 16719-16720 . denotes .
T26125 16718-16719 -RRB- denotes )
T26124 16707-16712 JJ denotes white
T26123 16713-16718 NN denotes arrow
T26122 16706-16707 -LRB- denotes (
T26121 16693-16701 JJ denotes ureteric
T26120 16702-16705 NN denotes bud
T26119 16689-16692 DT denotes the
T26118 16686-16688 IN denotes in
T26117 16678-16685 VBN denotes reduced
T26116 16674-16677 CC denotes and
T26115 16661-16668 JJ denotes nephric
T26114 16669-16673 NN denotes duct
T26113 16657-16660 DT denotes the
T26112 16654-16656 IN denotes in
T26111 16638-16648 NN denotes expression
T26110 16629-16637 NN denotes reporter
T26109 16649-16653 JJ denotes lost
T26108 16624-16628 IN denotes with
T26107 16622-16624 , denotes ,
T26106 16614-16615 SYM denotes -
T26105 16613-16614 HYPH denotes /
T26104 16612-16613 SYM denotes -
T26103 16608-16612 NN denotes Pygo
T26102 16607-16608 HYPH denotes /
T26101 16606-16607 SYM denotes -
T26100 16605-16606 HYPH denotes /
T26099 16604-16605 SYM denotes -
T26098 16599-16604 NN denotes Pygo1
T26097 16597-16598 -RRB- denotes )
T26096 16616-16622 NN denotes embryo
T26095 16596-16597 LS denotes C
T26094 16595-16596 -LRB- denotes (
T26093 16594-16720 sentence denotes (C) Pygo1-/-/Pygo-/- embryo, with reporter expression lost in the nephric duct and reduced in the ureteric bud (white arrow).
T26092 16593-16594 . denotes .
T26091 16592-16593 -RRB- denotes )
T26090 16581-16586 JJ denotes white
T26089 16587-16592 NN denotes arrow
T26088 16580-16581 -LRB- denotes (
T26087 16576-16579 NN denotes bud
T26086 16567-16575 JJ denotes ureteric
T26085 16563-16566 CC denotes and
T26084 16561-16562 -RRB- denotes )
T26083 16546-16551 JJ denotes black
T26082 16552-16561 NN denotes arrowhead
T26081 16545-16546 -LRB- denotes (
T26080 16532-16539 JJ denotes nephric
T26079 16540-16544 NN denotes duct
T26445 17943-17944 . denotes .
T26444 17930-17934 VBD denotes were
T26443 17928-17929 -RRB- denotes )
T26442 17927-17928 NN denotes N
T26441 17926-17927 -LRB- denotes (
T26440 17923-17925 IN denotes in
T26439 17935-17943 VBN denotes bisected
T26438 17915-17922 NNS denotes kidneys
T26437 17911-17914 DT denotes The
T26436 17910-17944 sentence denotes The kidneys in (N) were bisected.
T26435 17909-17910 . denotes .
T26434 17896-17901 NN denotes E18.5
T26433 17894-17895 -RRB- denotes )
T26432 17889-17894 JJ denotes right
T26431 17888-17889 -LRB- denotes (
T26430 17886-17887 SYM denotes -
T26429 17885-17886 HYPH denotes /
T26428 17884-17885 SYM denotes -
T26427 17879-17884 NN denotes Pygo2
T26426 17878-17879 HYPH denotes /
T26425 17877-17878 SYM denotes -
T26424 17876-17877 HYPH denotes /
T26423 17875-17876 SYM denotes -
T26422 17870-17875 NN denotes Pygo1
T26421 17866-17869 CC denotes and
T26420 17864-17865 -RRB- denotes )
T26419 17860-17864 JJ denotes left
T26418 17859-17860 -LRB- denotes (
T26417 17857-17858 SYM denotes -
T26416 17856-17857 HYPH denotes /
T26415 17855-17856 SYM denotes +
T26414 17850-17855 NN denotes Pygo2
T26413 17849-17850 HYPH denotes /
T26412 17848-17849 SYM denotes -
T26411 17847-17848 HYPH denotes /
T26410 17846-17847 SYM denotes +
T26409 17841-17846 NN denotes Pygo1
T26408 17839-17840 -RRB- denotes )
T26407 17838-17839 LS denotes N
T26406 17836-17838 , denotes ,
T26405 17902-17909 NNS denotes kidneys
T26404 17835-17836 LS denotes M
T26403 17834-17835 -LRB- denotes (
T26402 17833-17910 sentence denotes (M, N) Pygo1+/-/Pygo2+/- (left) and Pygo1-/-/Pygo2-/- (right) E18.5 kidneys.
T26400 17818-17826 VBG denotes staining
T26399 17810-17817 RB denotes faintly
T26398 17806-17809 JJ denotes few
T26397 17804-17805 DT denotes a
T26396 17802-17803 -RRB- denotes )
T26395 17827-17832 NNS denotes cells
T26394 17801-17802 NN denotes K
T26393 17800-17801 -LRB- denotes (
T26392 17796-17799 IN denotes for
T26391 17789-17795 IN denotes except
T26390 17787-17789 , denotes ,
T26389 17786-17787 -RRB- denotes )
T26388 17772-17778 VBN denotes dashed
T26387 17779-17786 NNS denotes circles
T26386 17771-17772 -LRB- denotes (
T26385 17752-17762 VBG denotes developing
T26384 17763-17770 NNS denotes kidneys
T26383 17748-17751 DT denotes the
T26382 17745-17747 IN denotes of
T26381 17733-17744 NN denotes compartment
T26380 17724-17732 JJ denotes ureteric
T26379 17720-17723 CC denotes and
T26378 17713-17719 NN denotes ureter
T26377 17709-17712 DT denotes the
T26376 17706-17708 IN denotes in
T26375 17702-17705 CC denotes and
T26374 17700-17702 , denotes ,
T26373 17699-17700 -RRB- denotes )
T26372 17684-17689 JJ denotes white
T26371 17690-17699 NN denotes arrowhead
T26370 17683-17684 -LRB- denotes (
T26369 17662-17677 JJ denotes paramesonephric
T26368 17678-17682 NN denotes duct
T26367 17658-17661 DT denotes the
T26366 17655-17657 IN denotes in
T26365 17646-17649 VBD denotes was
T26364 17637-17645 NN denotes activity
T26363 17626-17628 , denotes ,
T26362 17625-17626 SYM denotes -
T26361 17624-17625 HYPH denotes /
T26360 17623-17624 SYM denotes -
T26359 17618-17623 NN denotes Pygo2
T26358 17617-17618 HYPH denotes /
T26357 17616-17617 SYM denotes -
T26356 17615-17616 HYPH denotes /
T26355 17614-17615 SYM denotes -
T26354 17628-17636 NN denotes reporter
T26353 17609-17614 NN denotes Pygo1
T26352 17608-17609 -RRB- denotes )
T26351 17607-17608 LS denotes L
T26350 17605-17607 , denotes ,
T26349 17650-17654 VBN denotes lost
T26348 17604-17605 LS denotes K
T26347 17603-17604 -LRB- denotes (
T26346 17602-17833 sentence denotes (K, L)Pygo1-/-/Pygo2-/-, reporter activity was lost in the paramesonephric duct (white arrowhead), and in the ureter and ureteric compartment of the developing kidneys (dashed circles), except for (K) a few faintly staining cells.
T26345 17601-17602 . denotes .
T26344 17597-17601 NN denotes duct
T26343 17581-17596 JJ denotes paramesonephric
T26342 17577-17580 CC denotes and
T26341 17572-17576 NN denotes tree
T26340 17563-17571 JJ denotes ureteric
T26339 17560-17562 IN denotes in
T26338 17549-17559 NN denotes expression
T26337 17544-17548 IN denotes with
T26336 17542-17544 , denotes ,
T26335 17541-17542 -RRB- denotes )
T26334 17540-17541 NN denotes L
T26333 17539-17540 -LRB- denotes (
T26332 17535-17538 CC denotes and
T26331 17533-17534 -RRB- denotes )
T26330 17532-17533 NN denotes K
T26329 17531-17532 -LRB- denotes (
T26328 17526-17530 IN denotes with
T26327 17517-17525 NN denotes parallel
T26326 17514-17516 IN denotes in
T26325 17504-17513 VBN denotes processed
T26324 17496-17503 NN denotes control
T26323 17494-17495 DT denotes a
T26322 17492-17494 , denotes ,
T26321 17491-17492 SYM denotes -
T26320 17490-17491 HYPH denotes /
T26319 17489-17490 SYM denotes +
T26318 17484-17489 NN denotes Pygo2
T26317 17483-17484 HYPH denotes /
T26316 17482-17483 SYM denotes -
T26315 17481-17482 HYPH denotes /
T26314 17480-17481 SYM denotes +
T26313 17474-17475 -RRB- denotes )
T26312 17475-17480 NN denotes Pygo1
T26311 17473-17474 LS denotes J
T26310 17472-17473 -LRB- denotes (
T26309 17471-17602 sentence denotes (J)Pygo1+/-/Pygo2+/-, a control processed in parallel with (K) and (L), with expression in ureteric tree and paramesonephric duct.
T26308 17470-17471 . denotes .
T26307 17464-17470 NN denotes kidney
T26306 17460-17463 DT denotes the
T26305 17457-17459 IN denotes in
T26304 17446-17456 NN denotes expression
T26303 17441-17445 NN denotes tree
T26302 17432-17440 JJ denotes ureteric
T26301 17424-17431 VBG denotes showing
T26300 17412-17418 JJ denotes dorsal
T26299 17410-17411 -RRB- denotes )
T26298 17419-17423 NN denotes view
T26297 17409-17410 LS denotes I
T26296 17408-17409 -LRB- denotes (
T26295 17404-17407 CC denotes and
T26078 16528-16531 DT denotes the
T26077 16525-16527 IN denotes in
T26076 16516-16524 NN denotes activity
T26075 16507-16515 NN denotes reporter
T26074 16502-16503 HYPH denotes -
T26073 16503-16506 NN denotes gal
T26072 16499-16502 NN denotes BAT
T26071 16494-16498 IN denotes with
T26070 16481-16486 NN denotes E10.5
T26069 16479-16480 SYM denotes -
T26068 16478-16479 HYPH denotes /
T26067 16477-16478 SYM denotes +
T26066 16472-16477 NN denotes Pygo2
T26065 16471-16472 HYPH denotes /
T26064 16470-16471 SYM denotes -
T26063 16469-16470 HYPH denotes /
T26062 16468-16469 SYM denotes -
T26061 16463-16468 NN denotes Pygo1
T26060 16461-16462 -RRB- denotes )
T26059 16487-16493 NN denotes embryo
T26058 16460-16461 LS denotes B
T26057 16459-16460 -LRB- denotes (
T26056 16458-16594 sentence denotes (B) Pygo1-/-/Pygo2+/- E10.5 embryo with BAT-gal reporter activity in the nephric duct (black arrowhead) and ureteric bud (white arrow).
T26055 16457-16458 . denotes .
T26054 16456-16457 -RRB- denotes )
T26053 16451-16456 JJ denotes Right
T26052 16450-16451 -LRB- denotes (
T26051 16438-16442 JJ denotes null
T26050 16432-16437 NN denotes Pygo2
T26049 16443-16449 NN denotes embryo
T26048 16428-16431 DT denotes the
T26047 16425-16427 IN denotes of
T26046 16423-16424 -RRB- denotes )
T26045 16412-16417 JJ denotes white
T26044 16418-16423 NN denotes arrow
T26043 16411-16412 -LRB- denotes (
T26042 16398-16406 JJ denotes ureteric
T26041 16407-16410 NN denotes bud
T26040 16394-16397 DT denotes the
T26039 16391-16393 IN denotes in
T26038 16382-16390 NN denotes staining
T26037 16379-16381 IN denotes of
T26036 16369-16378 NN denotes reduction
T26035 16365-16368 CC denotes and
T26034 16363-16364 -RRB- denotes )
T26033 16348-16353 JJ denotes black
T26032 16354-16363 NN denotes arrowhead
T26031 16347-16348 -LRB- denotes (
T26030 16334-16341 JJ denotes nephric
T26029 16342-16346 NN denotes duct
T26028 16330-16333 DT denotes the
T26027 16327-16329 IN denotes in
T26026 16318-16326 NN denotes activity
T26025 16309-16317 NN denotes reporter
T26024 16306-16308 IN denotes of
T26023 16301-16305 NN denotes loss
T26022 16297-16300 DT denotes the
T26021 16292-16296 VB denotes Note
T26020 16291-16458 sentence denotes Note the loss of reporter activity in the nephric duct (black arrowhead) and reduction of staining in the ureteric bud (white arrow) of the Pygo2 null embryo (Right).
T26019 16290-16291 . denotes .
T26018 16289-16290 -RRB- denotes )
T26017 16284-16289 JJ denotes right
T26016 16283-16284 -LRB- denotes (
T26015 16281-16282 SYM denotes -
T26014 16280-16281 HYPH denotes /
T25984 16223-16230 NNS denotes kidneys
T25983 16212-16213 NN denotes M
T25982 16211-16212 -LRB- denotes (
T25981 16207-16210 CC denotes and
T25980 16205-16207 , denotes ,
T25979 16188-16198 JJ denotes urogenital
T25978 16180-16181 -RRB- denotes )
T25977 16179-16180 NN denotes L
T25976 16178-16179 SYM denotes -
T25975 16182-16187 NN denotes E13.5
T25974 16177-16178 NN denotes E
T25973 16176-16177 -LRB- denotes (
T25972 16172-16175 CC denotes and
T25971 16170-16172 , denotes ,
T25970 16163-16164 -RRB- denotes )
T25969 16162-16163 NN denotes C
T25968 16161-16162 SYM denotes -
T25967 16165-16170 NN denotes E10.5
T25966 16160-16161 NN denotes A
T25965 16159-16160 -LRB- denotes (
T25964 16199-16205 NNS denotes tracts
T25963 16148-16158 JJ denotes transgenic
T25962 16143-16144 HYPH denotes -
T25961 16144-16147 NN denotes gal
T25960 16140-16143 NN denotes BAT
T25959 16137-16139 IN denotes of
T25958 16128-16136 NN denotes staining
T25957 16123-16124 HYPH denotes -
T25956 16124-16127 NN denotes Gal
T25955 16122-16123 NN denotes X
T25954 16121-16231 sentence denotes X-Gal staining of BAT-gal transgenic (A-C) E10.5, and (E-L) E13.5 urogenital tracts, and (M-O) E18.5 kidneys.
T25953 16120-16121 . denotes .
T25952 16103-16113 VBG denotes developing
T25951 16114-16120 NN denotes kidney
T25950 16099-16102 DT denotes the
T25949 16096-16098 IN denotes of
T25948 16085-16095 NNS denotes structures
T25947 16076-16077 HYPH denotes -
T25946 16077-16084 VBN denotes derived
T25945 16073-16076 NN denotes bud
T25944 16064-16072 JJ denotes ureteric
T25943 16061-16063 IN denotes in
T25942 16050-16060 NN denotes expression
T25941 16041-16049 NN denotes reporter
T25940 16036-16037 HYPH denotes -
T25939 16037-16040 NN denotes gal
T25938 16033-16036 NN denotes BAT
T25937 16029-16032 IN denotes for
T25936 16017-16019 VBZ denotes is
T25935 16020-16028 VBN denotes required
T25934 16011-16016 NN denotes Pygo2
T26013 16279-16280 SYM denotes -
T26012 16274-16279 NN denotes Pygo2
T26011 16273-16274 HYPH denotes /
T26010 16272-16273 SYM denotes -
T26009 16271-16272 HYPH denotes /
T26008 16270-16271 SYM denotes +
T26007 16265-16270 NN denotes Pygo1
T26006 16261-16264 CC denotes and
T26005 16259-16260 -RRB- denotes )
T26004 16255-16259 JJ denotes left
T26003 16254-16255 -LRB- denotes (
T26002 16252-16253 SYM denotes +
T26001 16251-16252 HYPH denotes /
T26000 16250-16251 SYM denotes +
T25999 16245-16250 NN denotes Pygo2
T25998 16244-16245 HYPH denotes /
T25997 16243-16244 SYM denotes -
T25996 16242-16243 HYPH denotes /
T25995 16241-16242 SYM denotes -
T25994 16234-16235 -RRB- denotes )
T25993 16236-16241 NN denotes Pygo1
T25992 16233-16234 LS denotes A
T25991 16232-16233 -LRB- denotes (
T25990 16231-16291 sentence denotes (A) Pygo1-/-/Pygo2+/+ (left) and Pygo1+/-/Pygo2-/- (right).
T25989 16230-16231 . denotes .
T25988 16217-16222 NN denotes E18.5
T25987 16215-16216 -RRB- denotes )
T25986 16214-16215 NN denotes O
T25985 16213-16214 SYM denotes -
T24498 15397-15398 SYM denotes ×
T24497 15395-15396 -RRB- denotes )
T24496 15399-15401 CD denotes 16
T24495 15392-15394 , denotes ,
T24494 15391-15392 NN denotes C
T24493 15394-15395 NN denotes D
T24492 15390-15391 -LRB- denotes (
T24491 15388-15389 : denotes ;
T24490 15384-15385 SYM denotes ×
T24489 15382-15383 -RRB- denotes )
T24488 15379-15381 , denotes ,
T24487 15378-15379 NN denotes A
T24486 15381-15382 NN denotes B
T24485 15377-15378 -LRB- denotes (
T24484 15386-15388 CD denotes 20
T24483 15363-15376 NN denotes magnification
T24482 15354-15362 JJ denotes Original
T24481 15353-15402 sentence denotes Original magnification (A, B) × 20; (C, D) × 16.
T24480 15352-15353 . denotes .
T24479 15328-15343 RB denotes developmentally
T24478 15344-15352 JJ denotes advanced
T24477 15323-15327 RBR denotes more
T24476 15314-15322 RB denotes slightly
T24475 15309-15313 VBD denotes were
T24474 15305-15308 CC denotes and
T24473 15303-15305 , denotes ,
T24472 15295-15303 NN denotes parallel
T24471 15292-15294 IN denotes in
T24470 15282-15291 VBN denotes processed
T24469 15277-15281 RB denotes also
T24468 15275-15277 , denotes ,
T24467 15260-15268 JJ denotes separate
T24466 15269-15275 NN denotes litter
T24465 15258-15259 DT denotes a
T24464 15253-15257 IN denotes from
T24463 15246-15247 -RRB- denotes )
T24462 15245-15246 NN denotes D
T24461 15244-15245 -LRB- denotes (
T24460 15240-15243 CC denotes and
T24459 15238-15239 -RRB- denotes )
T24458 15237-15238 NN denotes C
T24457 15236-15237 -LRB- denotes (
T24456 15233-15235 IN denotes in
T24455 15225-15232 NNS denotes embryos
T24454 15248-15252 VBD denotes were
T24453 15219-15224 IN denotes while
T24452 15217-15219 , denotes ,
T24451 15209-15217 NN denotes parallel
T24450 15206-15208 IN denotes in
T24449 15196-15205 VBN denotes processed
T24448 15191-15195 VBD denotes were
T24447 15187-15190 CC denotes and
T24446 15175-15179 JJ denotes same
T24445 15180-15186 NN denotes litter
T24444 15171-15174 DT denotes the
T24443 15166-15170 IN denotes from
T24442 15159-15160 -RRB- denotes )
T24441 15158-15159 NN denotes B
T24440 15157-15158 -LRB- denotes (
T24439 15153-15156 CC denotes and
T24438 15151-15152 -RRB- denotes )
T24437 15149-15150 -LRB- denotes (
T24436 15150-15151 NN denotes A
T24435 15142-15148 NNS denotes panels
T24434 15139-15141 IN denotes in
T24433 15161-15165 VBD denotes were
T24432 15131-15138 NNS denotes Embryos
T24431 15130-15353 sentence denotes Embryos in panels (A) and (B) were from the same litter and were processed in parallel, while embryos in (C) and (D) were from a separate litter, also processed in parallel, and were slightly more developmentally advanced.
T24430 15129-15130 . denotes .
T24429 15116-15119 NN denotes Wnt
T24428 15106-15115 JJ denotes canonical
T24427 15120-15129 NN denotes signaling
T24426 15097-15105 JJ denotes residual
T24425 15086-15096 VBG denotes suggesting
T24424 15084-15086 , denotes ,
T24423 15069-15070 HYPH denotes -
T24422 15070-15073 NN denotes gal
T24421 15066-15069 NN denotes BAT
T24420 15056-15065 VBG denotes remaining
T24419 15074-15084 NN denotes expression
T24418 15051-15055 DT denotes some
T24417 15038-15043 RB denotes still
T24416 15028-15029 SYM denotes -
T24415 15027-15028 HYPH denotes /
T24414 15026-15027 SYM denotes -
T24413 15021-15026 NN denotes Pygo2
T24412 15020-15021 HYPH denotes /
T24411 15019-15020 SYM denotes -
T24410 15018-15019 HYPH denotes /
T24409 15017-15018 SYM denotes -
T24408 15012-15017 JJ denotes Pygo1
T24407 15005-15011 NN denotes mutant
T24406 15030-15037 NNS denotes embryos
T24405 14993-14994 HYPH denotes -
T24404 14994-15004 JJ denotes homozygous
T24403 14987-14993 JJ denotes Double
T24402 14985-14986 -RRB- denotes )
T24401 15044-15050 VBD denotes showed
T24400 14984-14985 LS denotes D
T24399 14983-14984 -LRB- denotes (
T24398 14982-15130 sentence denotes (D) Double-homozygous mutant Pygo1-/-/Pygo2-/- embryos still showed some remaining BAT-gal expression, suggesting residual canonical Wnt signaling.
T24397 14981-14982 . denotes .
T24396 14966-14967 HYPH denotes -
T24394 14963-14966 NN denotes BAT
T24393 14971-14981 NN denotes expression
T24392 14956-14962 JJ denotes normal
T24391 14947-14949 , denotes ,
T24390 14935-14940 NN denotes Pygo2
T24389 14929-14930 HYPH denotes -
T24388 14930-14934 NN denotes type
T24387 14925-14929 JJ denotes wild
T24386 14941-14947 NN denotes allele
T24385 14921-14924 CD denotes one
T24384 14917-14920 CC denotes but
T24383 14915-14917 , denotes ,
T24382 14902-14907 NN denotes Pygo1
T24381 14908-14915 NNS denotes alleles
T24380 14897-14901 DT denotes both
T24379 14894-14896 IN denotes of
T24378 14885-14893 NN denotes mutation
T24377 14880-14884 IN denotes with
T24376 14878-14880 , denotes ,
T24375 14870-14871 SYM denotes -
T24374 14869-14870 HYPH denotes /
T24373 14868-14869 SYM denotes +
T24372 14863-14868 NN denotes Pygo2
T24371 14862-14863 HYPH denotes /
T24370 14861-14862 SYM denotes -
T24369 14860-14861 HYPH denotes /
T24368 14859-14860 SYM denotes -
T24367 14872-14878 NN denotes embryo
T24366 14854-14859 NN denotes Pygo1
T24365 14852-14853 -RRB- denotes )
T24364 14949-14955 VBD denotes showed
T24363 14851-14852 LS denotes C
T24362 14850-14851 -LRB- denotes (
T24361 14849-14982 sentence denotes (C) Pygo1-/-/Pygo2+/- embryo, with mutation of both Pygo1 alleles, but one wild-type Pygo2 allele, showed normal BAT-gal expression.
T24360 14848-14849 . denotes .
T24359 14841-14848 NNS denotes somites
T24358 14837-14840 CC denotes and
T24357 14835-14837 , denotes ,
T24356 14828-14835 NN denotes vesicle
T24305 14599-14603 JJ denotes fore
T24304 14618-14622 NNS denotes buds
T24303 14595-14598 DT denotes the
T24302 14592-14594 IN denotes of
T24301 14574-14584 JJ denotes ectodermal
T24300 14585-14591 NNS denotes ridges
T24299 14567-14573 JJ denotes apical
T24298 14565-14567 , denotes ,
T24297 14558-14565 NN denotes vesicle
T24296 14553-14557 JJ denotes otic
T24295 14551-14553 , denotes ,
T24294 14544-14551 NNS denotes pouches
T24293 14533-14543 JJ denotes pharyngeal
T24292 14531-14533 , denotes ,
T24291 14515-14525 VBG denotes developing
T24290 14526-14531 NN denotes brain
T24289 14511-14514 DT denotes the
T24288 14508-14510 IN denotes in
T24287 14494-14495 HYPH denotes -
T24286 14495-14498 NN denotes gal
T24285 14493-14494 NN denotes X
T24284 14499-14507 NN denotes staining
T24283 14486-14492 JJ denotes normal
T24282 14469-14470 SYM denotes -
T24281 14468-14469 HYPH denotes /
T24280 14467-14468 SYM denotes +
T24279 14462-14467 NN denotes Pygo2
T24278 14461-14462 HYPH denotes /
T24277 14460-14461 SYM denotes +
T24276 14459-14460 HYPH denotes /
T24275 14458-14459 SYM denotes +
T24274 14471-14478 NNS denotes embryos
T24273 14453-14458 NN denotes Pygo1
T24272 14451-14452 -RRB- denotes )
T24271 14479-14485 VBD denotes showed
T24270 14450-14451 LS denotes A
T24269 14449-14450 -LRB- denotes (
T24268 14448-14639 sentence denotes (A) Pygo1+/+/Pygo2+/- embryos showed normal X-gal staining in the developing brain, pharyngeal pouches, otic vesicle, apical ectodermal ridges of the fore and hind limb buds, and in somites.
T24267 14447-14448 . denotes .
T24266 14434-14437 NN denotes Wnt
T24265 14438-14447 NN denotes signaling
T24264 14424-14433 JJ denotes canonical
T24263 14421-14423 IN denotes of
T24262 14402-14411 NN denotes transgene
T24261 14397-14398 HYPH denotes -
T24260 14398-14401 NN denotes gal
T24259 14394-14397 NN denotes BAT
T24258 14412-14420 NN denotes reporter
T24257 14390-14393 DT denotes the
T24256 14385-14389 IN denotes with
T24255 14381-14384 DT denotes all
T24254 14379-14381 , denotes ,
T24253 14372-14379 NNS denotes embryos
T24252 14366-14371 NN denotes E10.5
T24251 14365-14448 sentence denotes E10.5 embryos, all with the BAT-gal transgene reporter of canonical Wnt signaling.
T24250 14364-14365 . denotes .
T24249 14357-14364 NNS denotes embryos
T24248 14343-14344 HYPH denotes /
T24247 14344-14349 NN denotes Pygo2
T24246 14338-14343 NN denotes Pygo1
T24245 14334-14337 CC denotes and
T24244 14350-14356 NN denotes mutant
T24243 14328-14333 NN denotes Pygo2
T24242 14325-14327 IN denotes in
T24241 14311-14314 NN denotes Wnt
T24240 14301-14310 JJ denotes canonical
T24239 14315-14324 NN denotes signaling
T24238 14293-14300 VBN denotes Reduced
T24355 14823-14827 JJ denotes otic
T24354 14821-14823 , denotes ,
T24353 14814-14821 NNS denotes pouches
T24352 14803-14813 JJ denotes pharyngeal
T24351 14793-14802 VBG denotes including
T24350 14791-14793 , denotes ,
T24349 14770-14780 VBG denotes developing
T24348 14781-14791 NNS denotes structures
T24347 14765-14769 JJ denotes many
T24346 14762-14764 IN denotes in
T24345 14751-14761 NN denotes expression
T24344 14737-14738 HYPH denotes -
T24343 14738-14741 NN denotes gal
T24342 14734-14737 NN denotes BAT
T24341 14727-14733 JJ denotes absent
T24340 14723-14726 RB denotes not
T24339 14719-14722 CC denotes but
T24338 14742-14750 NN denotes reporter
T24337 14711-14718 JJ denotes reduced
T24336 14702-14704 , denotes ,
T24335 14689-14694 NN denotes Pygo2
T24334 14695-14702 NNS denotes alleles
T24333 14684-14688 DT denotes both
T24332 14681-14683 IN denotes of
T24331 14676-14680 NN denotes loss
T24330 14671-14675 IN denotes with
T24329 14669-14671 , denotes ,
T24328 14660-14661 SYM denotes -
T24327 14659-14660 HYPH denotes /
T24326 14658-14659 SYM denotes -
T24325 14653-14658 NN denotes Pygo2
T24324 14652-14653 HYPH denotes /
T24323 14651-14652 SYM denotes -
T24322 14650-14651 HYPH denotes /
T24321 14649-14650 SYM denotes +
T24320 14662-14669 NNS denotes embryos
T24319 14644-14649 NN denotes Pygo1
T24318 14642-14643 -RRB- denotes )
T24317 14704-14710 VBD denotes showed
T24316 14641-14642 LS denotes B
T24315 14640-14641 -LRB- denotes (
T24314 14639-14849 sentence denotes (B) Pygo1+/-/Pygo2-/- embryos, with loss of both Pygo2 alleles, showed reduced but not absent BAT-gal reporter expression in many developing structures, including pharyngeal pouches, otic vesicle, and somites.
T24313 14638-14639 . denotes .
T24312 14631-14638 NNS denotes somites
T24311 14628-14630 IN denotes in
T24310 14624-14627 CC denotes and
T24309 14622-14624 , denotes ,
T24308 14608-14612 JJ denotes hind
T24307 14604-14607 CC denotes and
T24306 14613-14617 NN denotes limb
T23681 13631-13632 . denotes .
T23680 13627-13628 SYM denotes ×
T23679 13629-13631 CD denotes 32
T23678 13613-13626 NN denotes magnification
T23677 13604-13612 JJ denotes Original
T23676 13603-13632 sentence denotes Original magnification × 32.
T23675 13602-13603 . denotes .
T23674 13597-13602 NN denotes Wnt11
T23673 13594-13596 IN denotes by
T23672 13585-13593 VBN denotes measured
T23671 13582-13584 IN denotes as
T23670 13577-13581 NNS denotes tips
T23669 13568-13576 JJ denotes ureteric
T23668 13565-13567 IN denotes of
T23667 13557-13564 NN denotes density
T23666 13549-13556 VBN denotes reduced
T23665 13545-13548 CC denotes and
T23664 13543-13545 , denotes ,
T23663 13538-13543 NN denotes Wnt9b
T23662 13534-13537 CC denotes and
T23661 13528-13533 NN denotes Wnt7b
T23660 13514-13519 NN denotes stalk
T23659 13505-13513 JJ denotes ureteric
T23658 13520-13527 NNS denotes markers
T23657 13501-13504 DT denotes the
T23656 13497-13500 IN denotes for
T23655 13477-13487 NN denotes expression
T23654 13488-13496 NNS denotes patterns
T23653 13470-13476 JJ denotes normal
T23652 13463-13469 VBD denotes showed
T23651 13448-13454 NN denotes mutant
T23650 13455-13462 NNS denotes kidneys
T23649 13444-13447 DT denotes The
T23648 13443-13603 sentence denotes The mutant kidneys showed normal expression patterns for the ureteric stalk markers Wnt7b and Wnt9b, and reduced density of ureteric tips as measured by Wnt11.
T23647 13442-13443 . denotes .
T23646 13435-13436 -RRB- denotes )
T23645 13437-13442 NN denotes Wnt11
T23644 13432-13434 , denotes ,
T23643 13431-13432 NN denotes C
T23642 13434-13435 NN denotes F
T23641 13430-13431 -LRB- denotes (
T23640 13426-13429 CC denotes and
T23639 13424-13426 , denotes ,
T23638 13417-13418 -RRB- denotes )
T23637 13419-13424 NN denotes Wnt9b
T23636 13414-13416 , denotes ,
T23635 13413-13414 NN denotes B
T23634 13416-13417 NN denotes E
T23633 13412-13413 -LRB- denotes (
T23632 13410-13412 , denotes ,
T23631 13403-13404 -RRB- denotes )
T23630 13405-13410 NN denotes Wnt7b
T23629 13400-13402 , denotes ,
T23628 13399-13400 NN denotes A
T23627 13402-13403 NN denotes D
T23626 13398-13399 -LRB- denotes (
T23625 13396-13398 : denotes :
T23624 13378-13388 JJ denotes derivative
T23623 13374-13377 NN denotes bud
T23622 13365-13373 JJ denotes ureteric
T23621 13389-13396 NNS denotes markers
T23620 13361-13364 DT denotes the
T23619 13356-13360 IN denotes with
T23618 13339-13340 SYM denotes -
T23617 13338-13339 HYPH denotes /
T23616 13337-13338 SYM denotes -
T23615 13332-13337 NN denotes Pygo2
T23614 13331-13332 HYPH denotes /
T23613 13330-13331 SYM denotes -
T23612 13329-13330 HYPH denotes /
T23611 13328-13329 SYM denotes -
T23610 13341-13347 NN denotes mutant
T23609 13323-13328 NN denotes Pygo1
T23608 13321-13322 -RRB- denotes )
T23607 13320-13321 NN denotes F
T23606 13319-13320 SYM denotes -
T23605 13348-13355 NNS denotes kidneys
T23604 13318-13319 NN denotes D
T23603 13317-13318 -LRB- denotes (
T23602 13313-13316 CC denotes and
T23601 13299-13300 HYPH denotes -
T23600 13300-13304 NN denotes type
T23599 13295-13299 JJ denotes wild
T23598 13289-13294 NN denotes E18.5
T23597 13287-13288 -RRB- denotes )
T23596 13286-13287 NN denotes C
T23595 13285-13286 SYM denotes -
T23594 13305-13312 NNS denotes kidneys
T23593 13284-13285 NN denotes A
T23592 13283-13284 -LRB- denotes (
T23591 13280-13282 IN denotes of
T23590 13265-13279 NNS denotes hybridizations
T23577 13207-13212 NN denotes Pygo1
T23576 13233-13240 NNS denotes kidneys
T23575 13201-13206 NN denotes E18.5
T23574 13198-13200 IN denotes in
T23573 13192-13197 NN denotes Wnt11
T23572 13188-13191 CC denotes and
T23571 13186-13188 , denotes ,
T23570 13181-13186 NN denotes Wnt9b
T23569 13179-13181 , denotes ,
T23568 13174-13179 NN denotes Wnt7b
T23567 13171-13173 IN denotes of
T23566 13160-13170 NN denotes Expression
T23292 11046-11049 DT denotes the
T23291 11043-11045 IN denotes in
T23290 11020-11033 RB denotes significantly
T23289 11015-11019 RB denotes also
T23288 11011-11014 VBD denotes was
T23287 10998-11006 JJ denotes ureteric
T23286 11007-11010 NN denotes bud
T23285 10994-10997 DT denotes the
T23284 10982-10993 VBG denotes surrounding
T23283 11034-11042 VBN denotes expanded
T23282 10961-10970 VBN denotes condensed
T23281 10971-10981 NN denotes mesenchyme
T23280 10957-10960 DT denotes The
T23279 10956-11058 sentence denotes The condensed mesenchyme surrounding the ureteric bud was also significantly expanded in the mutants.
T23278 10955-10956 . denotes .
T23277 10947-10955 NNS denotes controls
T23276 10942-10946 IN denotes with
T23275 10933-10941 VBN denotes compared
T23274 10925-10932 NNS denotes mutants
T23273 10918-10919 CD denotes 2
T23272 10917-10918 HYPH denotes /
T23271 10920-10924 JJ denotes null
T23270 10912-10917 NN denotes Pygo1
T23269 10909-10911 IN denotes in
T23268 10901-10908 JJ denotes dilated
T23267 10896-10900 RBR denotes more
T23266 10890-10895 RB denotes often
T23265 10880-10884 NNS denotes tips
T23264 10876-10879 NN denotes bud
T23263 10867-10875 JJ denotes ureteric
T23262 10865-10867 , denotes ,
T23261 10857-10865 NN denotes addition
T23260 10885-10889 VBD denotes were
T23259 10854-10856 IN denotes In
T23258 10853-10956 sentence denotes In addition, ureteric bud tips were often more dilated in Pygo1/2 null mutants compared with controls.
T23257 10852-10853 . denotes .
T23256 10833-10840 NN denotes control
T23255 10831-10832 -RRB- denotes )
T23254 10841-10852 NNS denotes littermates
T23253 10828-10830 , denotes ,
T23252 10827-10828 NN denotes A
T23251 10830-10831 NN denotes C
T23250 10826-10827 -LRB- denotes (
T23249 10821-10825 IN denotes with
T23248 10812-10820 VBN denotes compared
T23247 10799-10803 JJ denotes null
T23246 10792-10793 HYPH denotes /
T23245 10793-10798 NN denotes Pygo2
T23244 10787-10792 NN denotes Pygo1
T23243 10783-10786 DT denotes the
T23242 10781-10782 -RRB- denotes )
T23241 10804-10811 NNS denotes kidneys
T23240 10778-10780 , denotes ,
T23239 10777-10778 NN denotes B
T23238 10780-10781 NN denotes D
T23237 10776-10777 -LRB- denotes (
T23236 10773-10775 IN denotes in
T23235 10760-10763 VBD denotes was
T23234 10755-10759 NN denotes area
T23233 10751-10754 IN denotes per
T23232 10746-10750 NNS denotes tips
T23231 10737-10745 JJ denotes ureteric
T23230 10734-10736 IN denotes of
T23229 10764-10772 VBN denotes observed
T23228 10719-10726 VBN denotes reduced
T23227 10727-10733 NN denotes number
T23226 10717-10718 DT denotes A
T23225 10716-10853 sentence denotes A reduced number of ureteric tips per area was observed in (B, D) the Pygo1/Pygo2 null kidneys compared with (A, C) control littermates.
T23224 10715-10716 . denotes .
T23223 10713-10715 NN denotes μm
T23222 10709-10710 SYM denotes –
T23221 10710-10712 CD denotes 80
T23220 10707-10709 CD denotes 75
T23219 10703-10706 IN denotes for
T23218 10698-10699 CD denotes 5
T23217 10700-10702 NN denotes μm
T23216 10692-10697 DT denotes every
T23215 10678-10682 VBD denotes were
T23214 10683-10691 VBN denotes obtained
T23213 10668-10669 HYPH denotes -
T23212 10667-10668 NN denotes Z
T23211 10669-10677 NNS denotes sections
T23210 10658-10666 JJ denotes Confocal
T23209 10657-10716 sentence denotes Confocal Z-sections were obtained every 5 μm for 75–80 μm.
T23208 10656-10657 . denotes .
T23207 10655-10656 -RRB- denotes ]
T23206 10653-10655 CD denotes 16
T23205 10652-10653 -LRB- denotes [
T23204 10638-10646 JJ denotes ureteric
T23203 10647-10651 NN denotes tree
T23202 10634-10637 DT denotes the
T23201 10625-10633 VBG denotes staining
T23200 10618-10624 NN denotes lectin
T23199 10614-10617 NN denotes DBA
T23198 10610-10613 CC denotes and
T23197 10608-10610 , denotes ,
T23196 10607-10608 -RRB- denotes )
T23195 10603-10607 NN denotes blue
T23194 10602-10603 -LRB- denotes (
T23193 10592-10601 NNS denotes epithelia
T23192 10589-10591 IN denotes of
T23191 10574-10581 JJ denotes general
T23190 10582-10588 NN denotes marker
T22730 9404-9408 NN denotes blue
T22729 9391-9395 VBD denotes were
T22728 9389-9391 , denotes ,
T22727 9381-9389 NNS denotes sections
T22726 9375-9380 DT denotes these
T22725 9372-9374 IN denotes in
T22724 9359-9367 JJ denotes ureteric
T22723 9368-9371 NN denotes bud
T22722 9349-9358 RB denotes primarily
T22721 9347-9349 , denotes ,
T22720 9396-9403 VBN denotes labeled
T22719 9342-9347 NNS denotes cells
T22718 9331-9341 JJ denotes Epithelial
T22717 9330-9435 sentence denotes Epithelial cells, primarily ureteric bud in these sections, were labeled blue using E-cadherin antibody.
T22716 9329-9330 . denotes .
T22715 9328-9329 -RRB- denotes )
T22714 9322-9328 NNS denotes arrows
T22713 9321-9322 -LRB- denotes (
T22712 9304-9308 NN denotes cell
T22711 9296-9303 JJ denotes stromal
T22710 9309-9320 NN denotes compartment
T22709 9292-9295 DT denotes the
T22708 9289-9291 IN denotes in
T22707 9282-9288 NNS denotes levels
T22706 9273-9281 VBN denotes elevated
T22705 9268-9272 IN denotes with
T22704 9264-9267 CC denotes but
T22703 9262-9264 , denotes ,
T22702 9245-9255 VBG denotes developing
T22701 9256-9262 NN denotes kidney
T22700 9241-9244 DT denotes the
T22699 9238-9240 IN denotes of
T22698 9227-9237 NNS denotes components
T22697 9223-9226 DT denotes all
T22696 9220-9222 IN denotes in
T22695 9211-9219 VBN denotes detected
T22694 9204-9210 NN denotes signal
T22693 9199-9203 IN denotes with
T22692 9197-9199 , denotes ,
T22691 9187-9197 NN denotes expression
T22690 9176-9186 JJ denotes widespread
T22689 9169-9175 VBD denotes showed
T22688 9163-9168 NNS denotes genes
T22687 9158-9162 DT denotes Both
T22686 9157-9330 sentence denotes Both genes showed widespread expression, with signal detected in all components of the developing kidney, but with elevated levels in the stromal cell compartment (arrows).
T22685 9156-9157 . denotes .
T23189 10572-10573 DT denotes a
T23188 10570-10572 , denotes ,
T23187 10566-10570 NN denotes Cdh1
T23186 10564-10566 , denotes ,
T23185 10561-10564 NN denotes red
T23184 10558-10560 IN denotes as
T23183 10550-10557 VBN denotes colored
T23182 10546-10549 CC denotes and
T23181 10544-10546 , denotes ,
T23180 10522-10533 JJ denotes metanephric
T23179 10511-10521 VBG denotes condensing
T23178 10534-10544 NN denotes mesenchyme
T23177 10507-10510 DT denotes the
T23176 10504-10506 IN denotes in
T23175 10494-10503 VBN denotes expressed
T23174 10489-10493 RB denotes both
T23173 10487-10489 , denotes ,
T23172 10482-10483 -RRB- denotes )
T23171 10484-10487 NN denotes Wt1
T23170 10479-10481 , denotes ,
T23169 10478-10479 NN denotes A
T23168 10481-10482 NN denotes B
T23167 10477-10478 -LRB- denotes (
T23166 10474-10476 CC denotes or
T23165 10465-10466 -RRB- denotes )
T23164 10467-10473 NN denotes Cited1
T23163 10462-10464 , denotes ,
T23162 10461-10462 NN denotes C
T23161 10464-10465 NN denotes D
T23160 10460-10461 -LRB- denotes (
T23159 10457-10459 IN denotes to
T23129 10341-10342 LS denotes B
T23128 10340-10341 -LRB- denotes (
T23127 10339-10657 sentence denotes (B, D) Pygo1-/-/Pygo2-/- mutant E18.5 kidneys and (A, C) kidneys of normal littermates were stained using antibodies to (C, D) Cited1 or (A, B) Wt1, both expressed in the condensing metanephric mesenchyme, and colored as red, Cdh1, a general marker of epithelia (blue), and DBA lectin staining the ureteric tree [16].
T23126 10338-10339 . denotes .
T23125 10325-10330 NN denotes E18.5
T23124 10331-10338 NNS denotes kidneys
T23123 10318-10324 NN denotes mutant
T23122 10311-10312 HYPH denotes /
T23121 10312-10317 NN denotes Pygo2
T23120 10306-10311 NN denotes Pygo1
T23119 10303-10305 IN denotes of
T23118 10294-10302 NN denotes analysis
T23117 10285-10293 JJ denotes Confocal
T22684 9148-9156 VBN denotes expected
T22683 9145-9147 IN denotes as
T22682 9143-9145 , denotes ,
T22681 9136-9143 NN denotes nucleus
T22680 9132-9135 DT denotes the
T22679 9129-9131 IN denotes in
T22678 9114-9118 VBD denotes were
T22677 9112-9113 -RRB- denotes )
T22668 9085-9086 . denotes .
T22667 9073-9078 NN denotes E18.5
T22666 9079-9085 NN denotes kidney
T22665 9069-9072 DT denotes the
T22664 9066-9068 IN denotes of
T22663 9059-9065 NN denotes cortex
T22662 9055-9058 DT denotes the
T22661 9052-9054 IN denotes in
T22660 9037-9042 NN denotes Pygo2
T22659 9033-9036 CC denotes and
T22658 9027-9032 NN denotes Pygo1
T22657 9043-9051 NN denotes proteins
T22656 9023-9026 DT denotes the
T22655 9020-9022 IN denotes of
T22654 9011-9019 NNS denotes patterns
T22653 9000-9010 NN denotes expression
T22652 8990-8999 VB denotes determine
T22651 8987-8989 TO denotes to
T22650 8978-8981 VBD denotes was
T22649 8982-8986 VBN denotes used
T22648 8959-8977 NN denotes Immunofluorescence
T22647 8958-9086 sentence denotes Immunofluorescence was used to determine expression patterns of the Pygo1 and Pygo2 proteins in the cortex of the E18.5 kidney.
T22646 8957-8958 . denotes .
T22645 8940-8950 VBG denotes developing
T22644 8934-8939 NN denotes E18.5
T22643 8951-8957 NN denotes kidney
T22642 8930-8933 DT denotes the
T22641 8927-8929 IN denotes in
T22640 8910-8915 NN denotes Pygo2
T22639 8906-8909 CC denotes and
T22638 8916-8926 NN denotes expression
T22637 8900-8905 NN denotes Pygo1
T22075 45831-45835 NN denotes Actb
T22074 45830-45831 -LRB- denotes (
T22073 45809-45821 NN denotes housekeeping
T22072 45800-45808 JJ denotes internal
T22071 45822-45829 NN denotes control
T22070 45797-45799 DT denotes an
T22069 45794-45796 IN denotes to
T22068 45778-45782 VBD denotes were
T22067 45783-45793 VBN denotes normalized
T22066 45773-45777 NNS denotes data
T22065 45769-45772 DT denotes All
T22064 45768-45893 sentence denotes All data were normalized to an internal housekeeping control (Actb) and analyzed using the 2(-Delta Delta C(T)) method [38].
T22063 45767-45768 . denotes .
T22062 45759-45767 NN denotes amplicon
T22061 45755-45758 DT denotes the
T22060 45752-45754 IN denotes of
T22059 45740-45751 NN denotes specificity
T22058 45733-45739 VB denotes insure
T21924 44879-44887 NNP denotes Carlsbad
T21923 44877-44879 , denotes ,
T21922 44867-44877 NNP denotes Invitrogen
T21921 44866-44867 -LRB- denotes (
T21920 44856-44865 NNS denotes protocols
T21919 44843-44855 JJ denotes conventional
T21918 44840-44842 IN denotes to
T21917 44830-44839 VBG denotes according
T21916 44821-44829 NNS denotes hexamers
T21915 44814-44820 JJ denotes random
T21914 44808-44813 VBG denotes using
T21913 44794-44797 VBD denotes was
T21912 44798-44807 VBN denotes generated
T21911 44789-44793 NN denotes cDNA
T21910 44788-44898 sentence denotes cDNA was generated using random hexamers according to conventional protocols (Invitrogen, Carlsbad, CA, USA).
T21909 44787-44788 . denotes .
T21908 44778-44787 NN denotes treatment
T21907 44771-44777 NN denotes DNAse1
T21906 44761-44770 VBG denotes including
T21905 44759-44760 -RRB- denotes )
T21904 44756-44759 NNP denotes USA
T21903 44753-44755 NNP denotes CA
T21902 44751-44753 , denotes ,
T21901 44746-44751 NNP denotes Jolla
T21900 44743-44745 NNP denotes La
T21899 44741-44743 , denotes ,
T21898 44731-44741 NNP denotes Stratagene
T21897 44729-44730 : denotes ;
T21896 44716-44725 NN denotes Microprep
T21895 44712-44715 NNP denotes RNA
T21894 44726-44729 NN denotes Kit
T21893 44701-44711 NNP denotes Absolutely
T21892 44700-44701 -LRB- denotes (
T21891 44685-44695 JJ denotes commercial
T21890 44696-44699 NN denotes kit
T21889 44683-44684 DT denotes a
T21888 44677-44682 VBG denotes using
T21887 44664-44667 VBD denotes was
T23158 10446-10456 NNS denotes antibodies
T23157 10440-10445 VBG denotes using
T23156 10427-10431 VBD denotes were
T23155 10415-10426 NNS denotes littermates
T23154 10408-10414 JJ denotes normal
T23153 10405-10407 IN denotes of
T23152 10395-10396 -RRB- denotes )
T23151 10397-10404 NNS denotes kidneys
T23150 10392-10394 , denotes ,
T23149 10391-10392 NN denotes A
T23148 10394-10395 NN denotes C
T23147 10390-10391 -LRB- denotes (
T23146 10386-10389 CC denotes and
T23145 10372-10377 NN denotes E18.5
T23144 10378-10385 NNS denotes kidneys
T23143 10363-10364 SYM denotes -
T23142 10362-10363 HYPH denotes /
T23141 10361-10362 SYM denotes -
T23140 10356-10361 NN denotes Pygo2
T23139 10355-10356 HYPH denotes /
T23138 10354-10355 SYM denotes -
T23137 10353-10354 HYPH denotes /
T23136 10352-10353 SYM denotes -
T23135 10365-10371 NN denotes mutant
T23134 10347-10352 NN denotes Pygo1
T23133 10345-10346 -RRB- denotes )
T23132 10344-10345 LS denotes D
T23131 10342-10344 , denotes ,
T23130 10432-10439 VBN denotes stained
T21886 44662-44663 -RRB- denotes )
T21885 44654-44662 NN denotes analysis
T21884 44644-44653 NN denotes microrray
T21883 44640-44643 IN denotes for
T21882 44635-44639 VBN denotes used
T21881 44627-44634 NNS denotes kidneys
T21880 44623-44626 DT denotes the
T21879 44618-44622 IN denotes from
T21878 44609-44617 JJ denotes distinct
T21877 44605-44608 CC denotes and
T21876 44595-44604 NN denotes duplicate
T21875 44592-44594 IN denotes in
T21874 44580-44591 VBN denotes represented
T21873 44575-44579 CC denotes both
T21872 44574-44575 -LRB- denotes (
T21871 44558-44565 NN denotes control
T21870 44554-44557 CC denotes and
T21869 44549-44553 JJ denotes null
T21868 44542-44543 HYPH denotes /
T21867 44543-44548 NN denotes Pygo2
T21866 44537-44542 NN denotes Pygo1
T22057 45730-45732 TO denotes to
T22056 45720-45724 VBD denotes were
T22055 45716-45719 VBN denotes set
T22054 45709-45715 NN denotes primer
T22053 45704-45708 DT denotes each
T22052 45701-45703 IN denotes of
T22051 45725-45729 VBN denotes used
T22050 45687-45688 HYPH denotes -
T22049 45688-45691 NN denotes gel
T22048 45680-45687 NN denotes agarose
T22047 45676-45679 CC denotes and
T22046 45692-45700 NN denotes analysis
T22045 45670-45675 NN denotes curve
T22044 45657-45669 NN denotes Dissociation
T22043 45656-45768 sentence denotes Dissociation curve and agarose-gel analysis of each primer set were used to insure specificity of the amplicon.
T22042 45655-45656 . denotes .
T22041 45654-45655 -RRB- denotes )
T22040 45642-45643 : denotes ;
T22039 45635-45642 NN denotes Mx3000p
T22038 45644-45654 NNP denotes Stratagene
T22037 45634-45635 -LRB- denotes (
T22036 45623-45626 NN denotes PCR
T22035 45610-45622 JJ denotes quantitative
T22034 45627-45633 NN denotes system
T22033 45608-45609 DT denotes a
T22032 45602-45607 VBG denotes using
T22031 45600-45601 -RRB- denotes )
T22030 45590-45600 NNP denotes Stratagene
T22029 45589-45590 -LRB- denotes (
T22028 45574-45579 NNP denotes Green
T22027 45569-45573 NNP denotes SYBR
T22026 45556-45568 JJ denotes conventional
T22025 45580-45588 NN denotes protocol
T22024 45552-45555 DT denotes the
T22023 45549-45551 IN denotes to
T22022 45539-45548 VBG denotes according
T22021 45525-45528 VBD denotes was
T22020 45529-45538 VBN denotes performed
T22019 45508-45520 JJ denotes quantitative
T22018 45521-45524 NN denotes PCR
T22017 45499-45507 JJ denotes Relative
T22016 45498-45656 sentence denotes Relative quantitative PCR was performed according to the conventional SYBR Green protocol (Stratagene) using a quantitative PCR system (Mx3000p; Stratagene).
T22015 45497-45498 . denotes .
T22014 45496-45497 -RRB- denotes ]
T22013 45494-45496 CD denotes 37
T22012 45493-45494 -LRB- denotes [
T22011 45484-45492 NN denotes software
T22010 45476-45483 NN denotes Primer3
T22009 45470-45475 VBG denotes using
T22008 45468-45469 -RRB- denotes )
T22007 45446-45448 , denotes ,
T22006 45422-45446 NN denotes TGATTGAAGGGCTACTAGAGTGGT
T22005 45448-45468 NN denotes AGCCCCAGAGGACAATTTTT
T22004 45421-45422 -LRB- denotes (
T22003 45416-45420 NN denotes Tia1
T22002 45412-45415 CC denotes and
T22001 45410-45411 -RRB- denotes )
T22000 45388-45390 , denotes ,
T21999 45368-45388 NN denotes TTGTGAGCTGTAGCCAGGTG
T21998 45390-45410 NN denotes TGTGCACAGCTTGTCTCTCC
T21997 45367-45368 -LRB- denotes (
T21996 45362-45366 NN denotes Ren2
T21995 45360-45361 : denotes ;
T21994 45359-45360 -RRB- denotes )
T21993 45337-45339 , denotes ,
T21992 45317-45337 NN denotes TTCTGGGAACTTGTGCACTG
T21991 45339-45359 NN denotes AACTTCCTCCAGCCCATTTT
T21990 45316-45317 -LRB- denotes (
T21989 45310-45315 NN denotes Pygo2
T21988 45308-45309 : denotes ;
T21987 45307-45308 -RRB- denotes )
T21986 45286-45288 , denotes ,
T21985 45266-45286 NN denotes GGGAGGGAACAGAAATCCTT
T21984 45288-45307 NN denotes GCACCGATCAACAGTGCAG
T21983 45265-45266 -LRB- denotes (
T21982 45258-45264 NN denotes Picalm
T21981 45256-45257 : denotes ;
T21980 45255-45256 -RRB- denotes )
T21979 45233-45235 , denotes ,
T21978 45213-45233 NN denotes GCAGCATTACACCCGTCATA
T21977 45235-45255 NN denotes TTGCCTCCATCCATATCTCC
T21976 45212-45213 -LRB- denotes (
T21975 45207-45211 NN denotes Klk5
T21974 45205-45206 : denotes ;
T21973 45204-45205 -RRB- denotes )
T21972 45182-45184 , denotes ,
T21971 45162-45182 NN denotes CAGCATAGCCCAGGGTAGAG
T21970 45184-45204 NN denotes TGGGCAAGGTAGTGAAGGTT
T21969 45161-45162 -LRB- denotes (
T21968 45155-45160 NN denotes Csrp1
T21967 45153-45154 : denotes ;
T21966 45152-45153 -RRB- denotes )
T21965 45130-45132 , denotes ,
T21964 45110-45130 NN denotes GCAGACAGGCATCTTCACCT
T21963 45132-45152 NN denotes TGTGTACATCATGGGCTCGT
T21962 45109-45110 -LRB- denotes (
T21961 45102-45108 NN denotes Col8a1
T21960 45100-45101 : denotes ;
T21959 45099-45100 -RRB- denotes )
T21958 45074-45076 , denotes ,
T21957 45054-45074 NN denotes CCAGAAAGTGGTGTTTTGCT
T21956 45076-45099 NN denotes GAGTTACAGAGAGCTTGCACCTT
T21955 45053-45054 -LRB- denotes (
T21954 45045-45052 NN denotes Aldh1a7
T21953 45043-45044 : denotes ;
T21952 45042-45043 -RRB- denotes )
T21951 45020-45022 , denotes ,
T21950 45000-45020 NN denotes TTGCTGACAGGATGCAGAAG
T21949 45022-45042 NN denotes ACATCTGCTGGAAGGTGGAC
T21948 44999-45000 -LRB- denotes (
T21947 44994-44998 NN denotes Actb
T21946 44992-44994 : denotes :
T21945 44978-44986 NNP denotes Illumina
T21944 44987-44992 NN denotes probe
T21943 44974-44977 DT denotes the
T21942 44969-44973 IN denotes from
T21941 44960-44968 VBN denotes obtained
T21940 44951-44959 NN denotes sequence
T21939 44947-44950 DT denotes the
T21938 44939-44946 VB denotes include
T21937 44936-44938 TO denotes to
T21936 44921-44925 VBD denotes were
T21935 44926-44935 VBN denotes generated
T21934 44903-44912 VBG denotes following
T21933 44913-44920 NNS denotes primers
T21932 44899-44902 DT denotes The
T21931 44898-45498 sentence denotes The following primers were generated to include the sequence obtained from the Illumina probe: Actb (TTGCTGACAGGATGCAGAAG, ACATCTGCTGGAAGGTGGAC); Aldh1a7 (CCAGAAAGTGGTGTTTTGCT, GAGTTACAGAGAGCTTGCACCTT); Col8a1 (GCAGACAGGCATCTTCACCT, TGTGTACATCATGGGCTCGT); Csrp1 (CAGCATAGCCCAGGGTAGAG, TGGGCAAGGTAGTGAAGGTT); Klk5 (GCAGCATTACACCCGTCATA, TTGCCTCCATCCATATCTCC); Picalm (GGGAGGGAACAGAAATCCTT, GCACCGATCAACAGTGCAG); Pygo2 (TTCTGGGAACTTGTGCACTG, AACTTCCTCCAGCCCATTTT); Ren2 (TTGTGAGCTGTAGCCAGGTG, TGTGCACAGCTTGTCTCTCC) and Tia1 (TGATTGAAGGGCTACTAGAGTGGT, AGCCCCAGAGGACAATTTTT) using Primer3 software [37].
T21930 44897-44898 . denotes .
T21929 44896-44897 -RRB- denotes )
T21928 44893-44896 NNP denotes USA
T21927 44891-44893 , denotes ,
T21926 44889-44891 NNP denotes CA
T21925 44887-44889 , denotes ,
T21384 44390-44391 HYPH denotes -
T21382 44389-44390 NN denotes p
T21381 44399-44403 CD denotes 0.05
T21380 44388-44389 -LRB- denotes (
T21379 44375-44387 NN denotes significance
T21378 44363-44374 JJ denotes statistical
T21377 44359-44362 CC denotes and
T21376 44347-44351 NN denotes fold
T21375 44339-44346 JJ denotes average
T21374 44352-44358 NN denotes change
T21373 44325-44329 IN denotes than
T21372 44330-44338 RB denotes two-fold
T21371 44317-44324 JJR denotes greater
T21370 44314-44316 IN denotes of
T21369 44308-44313 NN denotes basis
T21368 44304-44307 DT denotes the
T21367 44301-44303 IN denotes on
T21366 44287-44291 VBD denotes were
T21365 44292-44300 VBN denotes selected
T21364 44281-44286 NNS denotes Genes
T21363 44280-44405 sentence denotes Genes were selected on the basis of greater than two-fold average fold change and statistical significance (p-value < 0.05).
T21362 44279-44280 . denotes .
T21361 44278-44279 -RRB- denotes )
T21360 44275-44278 NNP denotes USA
T21359 44273-44275 , denotes ,
T21358 44271-44273 NNP denotes CA
T21357 44269-44271 , denotes ,
T21356 44265-44269 NNP denotes Alto
T21355 44260-44264 NNP denotes Palo
T21354 44258-44260 , denotes ,
T21353 44238-44245 NNP denotes Agilent
T21352 44246-44258 NNP denotes Technologies
T21351 44237-44238 -LRB- denotes (
T21350 44233-44236 CD denotes 7.3
T21349 44230-44232 NNP denotes GX
T21348 44219-44229 NNP denotes GeneSpring
T21347 44214-44218 IN denotes into
T21346 44205-44213 VBN denotes imported
T21345 44201-44204 CC denotes and
T21344 44199-44200 -RRB- denotes )
T21343 44191-44199 NNP denotes Illumina
T21342 44190-44191 : denotes ;
T21341 44179-44189 NNP denotes Beadstudio
T21340 44178-44179 -LRB- denotes (
T21339 44160-44168 NN denotes analysis
T21338 44169-44177 NN denotes software
T21337 44155-44159 NNS denotes data
T21336 44150-44154 IN denotes from
T21335 44136-44140 VBD denotes were
T21334 44130-44135 NN denotes probe
T21333 44125-44129 DT denotes each
T21332 44122-44124 IN denotes of
T21331 44141-44149 VBN denotes obtained
T21330 44103-44109 NN denotes signal
T21329 44110-44121 NNS denotes intensities
T21328 44099-44102 JJ denotes Raw
T21327 44098-44280 sentence denotes Raw signal intensities of each probe were obtained from data analysis software (Beadstudio ;Illumina) and imported into GeneSpring GX 7.3 (Agilent Technologies, Palo Alto, CA, USA).
T21326 44097-44098 . denotes .
T21325 44087-44097 NN denotes triplicate
T21324 44076-44086 JJ denotes biological
T21323 44073-44075 IN denotes in
T21322 44059-44062 VBD denotes was
T21321 44051-44058 NNS denotes kidneys
T21320 44045-44046 HYPH denotes -
T21319 44041-44045 JJ denotes wild
T21318 44046-44050 NN denotes type
T21317 44034-44040 JJ denotes normal
T21316 44030-44033 CC denotes and
T21315 44025-44029 JJ denotes null
T21314 44018-44019 HYPH denotes /
T21313 44019-44024 NN denotes Pygo2
T21312 44013-44018 NN denotes Pygo1
T21311 44010-44012 IN denotes of
T21310 44063-44072 VBN denotes performed
T21309 44001-44009 NN denotes analysis
T21308 43990-44000 NN denotes Microarray
T21307 43989-44098 sentence denotes Microarray analysis of Pygo1/Pygo2 null and normal wild-type kidneys was performed in biological triplicate.
T21306 43988-43989 . denotes .
T21305 43987-43988 -RRB- denotes ]
T21304 43985-43987 CD denotes 36
T21303 43984-43985 -LRB- denotes [
T21302 43963-43973 RB denotes previously
T21301 43974-43983 VBN denotes described
T21300 43960-43962 IN denotes as
T21299 43955-43959 NNS denotes tags
T21298 43946-43954 NN denotes sequence
T21297 43936-43945 VBD denotes expressed
T21296 43932-43935 CC denotes and
T21295 43926-43931 NNS denotes genes
T21294 43920-43925 CD denotes 47000
T21293 43915-43919 IN denotes over
T21292 43912-43914 IN denotes of
T21291 43903-43911 NN denotes coverage
T21290 43893-43902 VBG denotes providing
T21289 43891-43892 -RRB- denotes )
T21288 43889-43891 NNP denotes CA
T21287 43887-43889 , denotes ,
T21286 43882-43887 NNP denotes Diego
T21285 43878-43881 NNP denotes San
T21284 43876-43878 , denotes ,
T21283 43868-43876 NNP denotes Illumina
T21282 43866-43867 : denotes ;
T21281 43847-43857 NN denotes expression
T21280 43845-43846 CD denotes 6
T21279 43844-43845 HYPH denotes -
T21278 43839-43844 NNP denotes Mouse
T21277 43858-43866 NN denotes Beadchip
T21276 43831-43838 NNP denotes Sentrix
T21275 43830-43831 -LRB- denotes (
T21274 43818-43829 NNS denotes microarrays
T21273 43815-43817 IN denotes to
T21272 43800-43803 VBD denotes was
T21271 43804-43814 VBN denotes hybridized
T21270 43796-43799 NN denotes RNA
T21269 43788-43795 VBN denotes Labeled
T21268 43787-43989 sentence denotes Labeled RNA was hybridized to microarrays (Sentrix Mouse-6 expression Beadchip; Illumina, San Diego, CA) providing coverage of over 47000 genes and expressed sequence tags as previously described [36].
T21267 43786-43787 . denotes .
T21266 43785-43786 -RRB- denotes )
T21265 43782-43785 NNP denotes USA
T21264 43780-43782 , denotes ,
T21263 43778-43780 NNP denotes WI
T21262 43776-43778 , denotes ,
T21261 43769-43776 NNP denotes Madison
T21260 43767-43769 , denotes ,
T21259 43758-43767 NNP denotes Epicentre
T21258 43756-43757 : denotes ;
T21257 43748-43749 HYPH denotes -
T21256 43749-43753 NN denotes aRNA
T21255 43738-43748 NN denotes Aminoallyl
T21254 43731-43732 HYPH denotes -
T21253 43732-43737 JJ denotes Round
T21252 43730-43731 CD denotes 1
T21251 43754-43756 NN denotes Ki
T21250 43720-43729 NNP denotes TargetAmp
T21249 43719-43720 -LRB- denotes (
T21248 43704-43714 JJ denotes commercial
T21247 43715-43718 NN denotes kit
T21246 43702-43703 DT denotes a
T21245 43696-43701 VBG denotes using
T21244 43688-43695 VBN denotes labeled
T21243 43684-43687 CC denotes and
T21242 43670-43673 VBD denotes was
T21241 43666-43669 NN denotes RNA
T21240 43660-43665 JJ denotes total
T21239 43657-43659 IN denotes of
T21238 43655-43656 -RRB- denotes )
T21237 43649-43652 CD denotes 300
T21236 43653-43655 NN denotes ng
T21235 43648-43649 -LRB- denotes (
T21234 43674-43683 VBN denotes processed
T21233 43640-43647 NN denotes aliquot
T21232 43637-43639 DT denotes An
T21231 43636-43787 sentence denotes An aliquot (300 ng) of total RNA was processed and labeled using a commercial kit (TargetAmp 1-Round Aminoallyl-aRNA Ki; Epicentre, Madison, WI, USA).
T21230 43635-43636 . denotes .
T21229 43634-43635 -RRB- denotes )
T21228 43629-43631 , denotes ,
T21227 43627-43629 NNP denotes CA
T21226 43625-43627 , denotes ,
T21225 43620-43625 NNP denotes Jolla
T21224 43617-43619 NNP denotes La
T21223 43631-43634 NNP denotes USA
T21222 43615-43616 : denotes ;
T21221 43602-43611 NNP denotes Microprep
T21220 43598-43601 NNP denotes RNA
T21219 43587-43597 NNP denotes Absolutely
T21218 43612-43615 NN denotes Kit
T21217 43576-43586 NNP denotes Stratagene
T21216 43575-43576 -LRB- denotes (
T21215 43560-43570 JJ denotes commercial
T21214 43571-43574 NN denotes kit
T21213 43558-43559 DT denotes a
T21212 43552-43557 VBG denotes using
T21211 43530-43538 NN denotes compound
T21210 43539-43543 JJ denotes null
T21209 43523-43524 HYPH denotes /
T21208 43524-43529 NN denotes Pygo2
T21207 43518-43523 NN denotes Pygo1
T21206 43514-43517 CC denotes and
T21205 43544-43551 NNS denotes embryos
T21204 43507-43513 JJ denotes normal
T21203 43502-43506 IN denotes from
T21202 43492-43501 VBN denotes dissected
T21201 43484-43491 NNS denotes kidneys
T21200 43478-43483 NN denotes E18.5
T21199 43473-43477 IN denotes from
T21198 43460-43463 VBD denotes was
T21197 43464-43472 VBN denotes isolated
T21196 43456-43459 NN denotes RNA
T21195 43450-43455 JJ denotes Total
T21194 43449-43636 sentence denotes Total RNA was isolated from E18.5 kidneys dissected from normal and Pygo1/Pygo2 compound null embryos using a commercial kit (Stratagene Absolutely RNA Microprep Kit; La Jolla, CA, USA).
T21193 43441-43449 NN denotes analysis
T21192 43430-43440 NN denotes Microarray
T20776 43383-43384 SYM denotes =
T20775 43381-43382 NN denotes n
T20774 43385-43386 CD denotes 8
T20773 43380-43381 -LRB- denotes (
T20772 43378-43379 SYM denotes -
T20771 43377-43378 HYPH denotes /
T20770 43376-43377 SYM denotes +
T20769 43371-43376 NN denotes Pygo2
T20768 43369-43370 : denotes ;
T20767 43367-43368 SYM denotes -
T20766 43366-43367 HYPH denotes /
T20765 43365-43366 SYM denotes -
T20764 43360-43365 NN denotes Pygo1
T20763 43358-43360 , denotes ,
T20762 43357-43358 -RRB- denotes )
T20761 43354-43355 SYM denotes =
T20760 43352-43353 NN denotes n
T20759 43356-43357 CD denotes 6
T20758 43351-43352 -LRB- denotes (
T20757 43349-43350 SYM denotes +
T20756 43348-43349 HYPH denotes /
T20755 43347-43348 SYM denotes +
T20754 43342-43347 NN denotes Pygo2
T20753 43340-43341 : denotes ;
T20752 43338-43339 SYM denotes -
T20751 43337-43338 HYPH denotes /
T20750 43336-43337 SYM denotes +
T20749 43331-43336 NN denotes Pygo1
T20748 43329-43331 , denotes ,
T20747 43328-43329 -RRB- denotes )
T20746 43325-43326 SYM denotes =
T20745 43323-43324 NN denotes n
T20744 43327-43328 CD denotes 5
T20743 43322-43323 -LRB- denotes (
T20742 43307-43321 JJ denotes non-transgenic
T20741 43421-43427 NNS denotes groups
T20740 43303-43306 DT denotes the
T20739 43296-43302 IN denotes except
T20738 43294-43295 CD denotes 4
T20737 43291-43293 IN denotes of
T20736 43279-43285 NN denotes sample
T20735 43286-43290 NN denotes size
T20734 43277-43278 DT denotes a
T20733 43274-43276 IN denotes by
T20732 43258-43261 VBD denotes was
T20731 43262-43273 VBN denotes represented
T20730 43249-43257 NN denotes genotype
T20729 43244-43248 DT denotes Each
T20728 43243-43428 sentence denotes Each genotype was represented by a sample size of 4 except the non-transgenic (n = 5), Pygo1+/- ; Pygo2+/+ (n = 6), Pygo1-/- ; Pygo2+/- (n = 8), and Pygo1-/- ; Pygo2-/- (n = 6) groups.
T20727 43242-43243 . denotes .
T20726 43235-43242 NN denotes protein
T20725 43229-43234 JJ denotes total
T20724 43226-43228 IN denotes to
T20723 43216-43225 VBG denotes according
T20722 43204-43215 VBG denotes normalizing
T20721 43202-43204 , denotes ,
T20720 43201-43202 -RRB- denotes )
T20719 43199-43201 NNP denotes IN
T20718 43197-43199 , denotes ,
T20717 43185-43197 NNP denotes Indianapolis
T20716 43183-43185 , denotes ,
T20715 43178-43183 NNP denotes Roche
T20714 43177-43178 -LRB- denotes (
T20713 43171-43172 -RRB- denotes )
T20712 43160-43171 NN denotes immunoassay
T20711 43152-43153 HYPH denotes -
T20710 43153-43159 VBN denotes linked
T20709 43146-43152 NN denotes Enzyme
T20708 43145-43146 -LRB- denotes (
T20707 43139-43144 NNP denotes ELISA
T20706 43134-43135 HYPH denotes -
T20705 43135-43138 NN denotes Gal
T20704 43133-43134 NN denotes β
T20703 43173-43176 NN denotes kit
T20702 43131-43132 DT denotes a
T20701 43125-43130 VBG denotes using
T20700 43108-43112 VBD denotes were
T20699 43097-43107 NN denotes expression
T20698 43092-43093 HYPH denotes -
T20697 43091-43092 NN denotes β
T20696 43093-43096 NN denotes Gal
T20695 43081-43090 NN denotes transgene
T20694 43078-43080 IN denotes in
T20693 43113-43124 VBN denotes quantitated
T20692 43070-43077 NNS denotes Changes
T20691 43069-43243 sentence denotes Changes in transgene β-Gal expression were quantitated using a β-Gal ELISA (Enzyme-linked immunoassay) kit (Roche, Indianapolis, IN), normalizing according to total protein.
T20690 43068-43069 . denotes .
T20689 43065-43068 CD denotes 8.0
T20688 43062-43064 IN denotes to
T20687 43044-43052 NN denotes staining
T20686 43039-43040 HYPH denotes -
T20685 43040-43043 NN denotes gal
T20684 43038-43039 NN denotes X
T20683 43053-43061 NN denotes solution
T20682 43034-43037 DT denotes the
T20681 43031-43033 IN denotes of
T20680 43028-43030 NN denotes pH
T20679 43017-43027 VBG denotes increasing
T20678 43014-43016 IN denotes by
T20677 42996-43006 VBG denotes developing
T20676 43007-43013 NN denotes kidney
T20675 42992-42995 DT denotes the
T20674 42985-42991 IN denotes within
T20673 42961-42962 HYPH denotes -
T20672 42962-42975 NN denotes galactosidase
T20671 42960-42961 NN denotes β
T20670 42976-42984 NN denotes activity
T20669 42949-42959 JJ denotes endogenous
T20668 42942-42948 VB denotes reduce
T20667 42939-42941 TO denotes to
T20666 42929-42932 VBD denotes was
T20665 42933-42938 VBN denotes taken
T20664 42924-42928 NN denotes Care
T20663 42923-43069 sentence denotes Care was taken to reduce endogenous β-galactosidase activity within the developing kidney by increasing pH of the X-gal staining solution to 8.0.
T20662 42922-42923 . denotes .
T20661 42921-42922 -RRB- denotes ]
T20660 42919-42921 CD denotes 21
T20659 42918-42919 -LRB- denotes [
T20658 42897-42907 RB denotes previously
T20657 42908-42917 VBN denotes described
T20656 42894-42896 IN denotes as
T20655 42880-42883 VBD denotes was
T20654 42872-42879 NNS denotes kidneys
T20653 42861-42871 VBG denotes developing
T20652 42857-42860 CC denotes and
T20651 42849-42856 NNS denotes embryos
T20650 42844-42848 CC denotes both
T20649 42841-42843 IN denotes of
T20648 42884-42893 VBN denotes performed
T20647 42832-42840 NN denotes staining
T20646 42827-42828 HYPH denotes -
T20645 42828-42831 NN denotes gal
T20644 42826-42827 NN denotes X
T20643 42825-42923 sentence denotes X-gal staining of both embryos and developing kidneys was performed as previously described [21].
T20642 42812-42815 NN denotes Wnt
T20641 42816-42825 NN denotes signaling
T20640 42802-42811 JJ denotes canonical
T20639 42799-42801 IN denotes of
T20638 42793-42798 NN denotes assay
T20637 42784-42792 NN denotes reporter
T20636 42774-42783 NN denotes transgene
T20635 42769-42770 HYPH denotes -
T20634 42770-42773 NN denotes gal
T20633 42766-42769 NN denotes BAT
T20283 42763-42764 . denotes .
T20282 42760-42763 NN denotes use
T20281 42753-42759 IN denotes before
T20280 42745-42752 NN denotes extract
T20279 42731-42737 NN denotes mutant
T20278 42738-42744 NN denotes embryo
T20277 42719-42720 HYPH denotes -
T20276 42713-42719 JJ denotes double
T20275 42711-42712 CD denotes 2
T20274 42710-42711 HYPH denotes /
T20273 42720-42730 JJ denotes homozygous
T20272 42705-42710 NN denotes Pygo1
T20271 42700-42704 IN denotes with
T20270 42678-42689 RB denotes extensively
T20269 42673-42677 VBD denotes were
T20268 42653-42661 VBN denotes purified
T20267 42662-42672 NNS denotes antibodies
T20266 42649-42652 DT denotes the
T20265 42647-42649 , denotes ,
T20264 42637-42647 NN denotes specficity
T20263 42628-42636 NN denotes antibody
T20262 42690-42699 VBN denotes incubated
T20261 42613-42620 RB denotes further
T20260 42621-42627 VB denotes ensure
T20259 42610-42612 TO denotes To
T20258 42609-42764 sentence denotes To further ensure antibody specficity, the purified antibodies were extensively incubated with Pygo1/2 double-homozygous mutant embryo extract before use.
T20257 42608-42609 . denotes .
T20256 42602-42608 NN denotes buffer
T20255 42594-42601 NN denotes elution
T20254 42589-42593 IN denotes with
T20253 42577-42581 VBD denotes were
T20252 42582-42588 VBN denotes eluted
T20251 42561-42566 VBN denotes bound
T20250 42567-42576 NNS denotes antibodes
T20249 42557-42560 DT denotes The
T20248 42556-42609 sentence denotes The bound antibodes were eluted with elution buffer.
T20247 42555-42556 . denotes .
T20246 42543-42555 RB denotes respectively
T20245 42541-42543 , denotes ,
T20244 42525-42533 NN denotes affinity
T20243 42517-42518 HYPH denotes -
T20242 42518-42524 NN denotes mPygo1
T20241 42514-42517 NN denotes GST
T20240 42511-42513 CC denotes or
T20239 42503-42504 HYPH denotes -
T20238 42504-42510 NN denotes hPygo2
T20237 42500-42503 NN denotes GST
T20236 42534-42541 NNS denotes columns
T20235 42496-42499 DT denotes the
T20234 42493-42495 IN denotes to
T20233 42488-42492 VB denotes bind
T20232 42485-42487 TO denotes to
T20231 42477-42484 VBN denotes allowed
T20230 42473-42476 CC denotes and
T20229 42457-42465 NN denotes affinity
T20228 42453-42456 NN denotes GST
T20227 42466-42472 NN denotes matrix
T20226 42449-42452 DT denotes the
T20225 42444-42448 IN denotes from
T20224 42429-42433 RB denotes then
T20223 42424-42428 VBD denotes were
T20222 42434-42443 VBN denotes separated
T20221 42403-42414 JJ denotes anti-mPygo1
T20220 42399-42402 CC denotes and
T20219 42387-42398 JJ denotes anti-hPygo2
T20218 42415-42423 NNS denotes antisera
T20217 42383-42386 DT denotes The
T20216 42382-42556 sentence denotes The anti-hPygo2 and anti-mPygo1 antisera were then separated from the GST affinity matrix and allowed to bind to the GST-hPygo2 or GST-mPygo1 affinity columns, respectively.
T20215 42381-42382 . denotes .
T20214 42378-42381 NN denotes GST
T20213 42370-42377 IN denotes against
T20212 42359-42369 NNS denotes antibodies
T20211 42355-42358 DT denotes any
T20210 42348-42354 VB denotes remove
T20209 42345-42347 TO denotes to
T20208 42329-42337 NN denotes affinity
T20207 42325-42328 NN denotes GST
T20206 42338-42344 NN denotes matrix
T20205 42321-42324 DT denotes the
T20204 42318-42320 IN denotes to
T20203 42313-42317 VB denotes bind
T20202 42310-42312 TO denotes to
T20201 42292-42301 RB denotes initially
T20200 42287-42291 VBD denotes were
T20199 42275-42286 JJ denotes anti-hPygo2
T20198 42271-42274 CC denotes and
T20197 42259-42270 JJ denotes anti-mPygo1
T20196 42256-42258 IN denotes of
T20195 42302-42309 VBN denotes allowed
T20194 42240-42246 NN denotes rabbit
T20141 41992-41995 CC denotes and
T20140 41990-41991 CD denotes 2
T20139 41984-41989 NN denotes hPygo
T20138 41981-41983 IN denotes of
T20137 42004-42008 VBP denotes lack
T20136 41967-41970 NN denotes PCR
T20135 41971-41980 NNS denotes fragments
T20134 41963-41966 DT denotes The
T20133 41962-42065 sentence denotes The PCR fragments of hPygo 2 and mPygo 1 lack both NHD and PHD conserved regions of hPygo2 and mPygo1.
T20132 41961-41962 . denotes .
T20131 41960-41961 -RRB- denotes )
T20130 41957-41960 NNP denotes USA
T20129 41955-41957 , denotes ,
T20128 41953-41955 NNP denotes NJ
T20127 41951-41953 , denotes ,
T20126 41941-41951 NNP denotes Piscataway
T20125 41939-41941 , denotes ,
T20124 41924-41932 NNP denotes Amersham
T20123 41933-41939 NNP denotes Health
T20122 41923-41924 -LRB- denotes (
T20121 41915-41922 NN denotes pGEX4T1
T20120 41910-41914 IN denotes into
T20119 41904-41909 NN denotes Pygo1
T20118 41898-41903 NN denotes mouse
T20117 41895-41897 IN denotes of
T20116 41891-41894 CD denotes 263
T20115 41890-41891 SYM denotes –
T20114 41879-41887 NNS denotes residues
T20113 41888-41890 CD denotes 76
T20112 41873-41874 HYPH denotes -
T20111 41874-41878 NN denotes acid
T20110 41868-41873 NN denotes amino
T20109 41865-41867 CC denotes or
T20108 41863-41864 CD denotes 2
T20107 41858-41862 NN denotes Pygo
T20106 41852-41857 JJ denotes human
T20105 41849-41851 IN denotes of
T20104 41845-41848 CD denotes 327
T20103 41844-41845 SYM denotes –
T20102 41833-41841 NNS denotes residues
T20101 41842-41844 CD denotes 80
T20100 41827-41828 HYPH denotes -
T20099 41828-41832 NN denotes acid
T20098 41822-41827 NN denotes amino
T20097 41819-41821 IN denotes to
T20096 41805-41818 VBG denotes corresponding
T20095 41801-41804 NN denotes PCR
T20094 41798-41800 IN denotes by
T20093 41793-41797 NN denotes cDNA
T20092 41780-41782 PRP denotes we
T20091 41778-41780 , denotes ,
T20090 41757-41767 JJ denotes polyclonal
T20089 41755-41756 -RRB- denotes )
T20088 41744-41755 JJ denotes anti-mPygo1
T20087 41743-41744 -LRB- denotes (
T20086 41737-41742 NN denotes Pygo1
T20085 41726-41736 JJ denotes anti-mouse
T20084 41722-41725 CC denotes and
T20083 41720-41721 -RRB- denotes )
T20082 41709-41720 JJ denotes anti-hPygo2
T20081 41708-41709 -LRB- denotes (
T20080 41768-41778 NNS denotes antibodies
T20079 41702-41707 NN denotes Pygo2
T20078 41691-41701 JJ denotes anti-human
T20077 41783-41792 VBD denotes subcloned
T20076 41682-41690 VB denotes generate
T20075 41679-41681 TO denotes To
T20074 41678-41962 sentence denotes To generate anti-human Pygo2 (anti-hPygo2) and anti-mouse Pygo1 (anti-mPygo1) polyclonal antibodies, we subcloned cDNA by PCR corresponding to amino-acid residues 80–327 of human Pygo 2 or amino-acid residues 76–263 of mouse Pygo1 into pGEX4T1 (Amersham Health, Piscataway, NJ, USA).
T20073 41668-41678 NN denotes production
T20072 41653-41658 NN denotes Pygo2
T20071 41649-41652 CC denotes and
T20070 41659-41667 NN denotes antibody
T20069 41643-41648 NN denotes Pygo1
T20193 42247-42255 NNS denotes antisera
T20192 42236-42239 DT denotes The
T20191 42235-42382 sentence denotes The rabbit antisera of anti-mPygo1 and anti-hPygo2 were initially allowed to bind to the GST affinity matrix to remove any antibodies against GST.
T20190 42234-42235 . denotes .
T20189 42233-42234 -RRB- denotes )
T20188 42230-42233 NNP denotes USA
T20187 42228-42230 , denotes ,
T20186 42226-42228 NNP denotes IL
T20185 42224-42226 , denotes ,
T20184 42217-42224 NNP denotes Chicago
T20183 42215-42217 , denotes ,
T20182 42205-42210 NNP denotes Group
T20181 42211-42215 NNP denotes Inc.
T20180 42193-42204 NNP denotes Proteintech
T20179 42192-42193 -LRB- denotes (
T20178 42189-42191 IN denotes by
T20177 42178-42188 NN denotes production
T20176 42169-42177 NN denotes antibody
T20175 42165-42168 IN denotes for
T20174 42157-42164 NNS denotes rabbits
T20173 42152-42156 IN denotes into
T20172 42143-42151 VBN denotes injected
T20171 42139-42142 CC denotes and
T20170 42137-42139 , denotes ,
T20169 42129-42137 VBN denotes purified
T20168 42127-42129 , denotes ,
T20167 42119-42127 NNS denotes bacteria
T20166 42116-42118 IN denotes in
T20165 42101-42105 VBD denotes were
T20164 42106-42115 VBN denotes expressed
T20163 42084-42085 HYPH denotes -
T20162 42085-42091 NN denotes mPygo1
T20161 42081-42084 NN denotes GST
T20160 42077-42080 CC denotes and
T20159 42092-42100 NN denotes proteins
T20158 42069-42070 HYPH denotes -
T20157 42070-42076 NN denotes hPygo2
T20156 42066-42069 NN denotes GST
T20155 42065-42235 sentence denotes GST-hPygo2 and GST-mPygo1 proteins were expressed in bacteria, purified, and injected into rabbits for antibody production by (Proteintech Group Inc., Chicago, IL, USA).
T20154 42064-42065 . denotes .
T20153 42058-42064 NN denotes mPygo1
T20152 42054-42057 CC denotes and
T20151 42047-42053 NN denotes hPygo2
T20150 42044-42046 IN denotes of
T20149 42036-42043 NNS denotes regions
T20148 42022-42025 NN denotes PHD
T20147 42018-42021 CC denotes and
T20146 42026-42035 VBN denotes conserved
T20145 42014-42017 NN denotes NHD
T20144 42009-42013 CC denotes both
T20143 42002-42003 CD denotes 1
T20142 41996-42001 NN denotes mPygo
T19252 40792-40803 JJ denotes anti-rabbit
T19251 40780-40781 HYPH denotes -
T19250 40777-40780 CD denotes 555
T19249 40781-40791 VBN denotes conjugated
T19248 40771-40776 NNP denotes Alexa
T19247 40766-40770 VBD denotes were
T19246 40745-40754 JJ denotes secondary
T19245 40755-40765 NNS denotes antibodies
T19244 40741-40744 DT denotes The
T19243 40740-40885 sentence denotes The secondary antibodies were Alexa 555-conjugated anti-rabbit and Alexa 633-conjugated anti-rat antibodies (Molecular Probes, Eugene, OR, USA).
T19242 40739-40740 . denotes .
T19241 40738-40739 -RRB- denotes )
T19240 40735-40738 NNP denotes USA
T19239 40733-40735 , denotes ,
T19238 40731-40733 NNP denotes CA
T19237 40729-40731 , denotes ,
T19236 40722-40729 NNP denotes Fremont
T19235 40720-40722 , denotes ,
T19234 40702-40708 NNP denotes Vision
T19233 40698-40701 NNP denotes Lab
T19232 40697-40698 HYPH denotes -
T19231 40687-40697 NNP denotes Neomarkers
T19230 40709-40720 NNP denotes Corporation
T19229 40686-40687 -LRB- denotes (
T19228 40674-40685 JJ denotes anti-Cited1
T19227 40670-40673 CC denotes and
T19226 40668-40670 , denotes ,
T19225 40667-40668 -RRB- denotes )
T19224 40664-40667 NNP denotes USA
T19223 40662-40664 , denotes ,
T19222 40660-40662 NNP denotes MO
T19221 40658-40660 , denotes ,
T19220 40653-40658 NNP denotes Louis
T19219 40649-40652 NNP denotes St.
T19218 40640-40641 HYPH denotes -
T19217 40635-40640 NNP denotes Sigma
T19216 40641-40648 NNP denotes Aldrich
T19215 40633-40635 , denotes ,
T19214 40629-40633 NN denotes Cdh1
T19213 40627-40629 , denotes ,
T19212 40618-40619 HYPH denotes -
T19211 40619-40627 NN denotes cadherin
T19210 40617-40618 NN denotes e
T19209 40616-40617 -LRB- denotes (
T19208 40600-40615 JJ denotes anti-uvomorulin
T19207 40598-40600 , denotes ,
T19206 40597-40598 -RRB- denotes )
T19205 40594-40597 NNP denotes USA
T19204 40592-40594 , denotes ,
T19203 40590-40592 NNP denotes CA
T19202 40588-40590 , denotes ,
T19201 40584-40588 NNP denotes Cruz
T19200 40578-40583 NNP denotes Santa
T19199 40576-40578 , denotes ,
T19198 40558-40562 NNP denotes Cruz
T19197 40552-40557 NNP denotes Santa
T19196 40550-40551 : denotes ;
T19195 40548-40550 CD denotes 19
T19194 40547-40548 HYPH denotes -
T19193 40546-40547 NN denotes c
T19192 40563-40576 NNP denotes Biotechnology
T19191 40545-40546 -LRB- denotes (
T19190 40536-40544 JJ denotes anti-WT1
T19189 40531-40535 VBD denotes were
T19188 40512-40519 JJ denotes primary
T19187 40520-40530 NNS denotes antibodies
T19186 40508-40511 DT denotes The
T19185 40507-40740 sentence denotes The primary antibodies were anti-WT1 (c-19; Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-uvomorulin (e-cadherin, Cdh1, Sigma-Aldrich St. Louis, MO, USA), and anti-Cited1 (Neomarkers-Lab Vision Corporation, Fremont, CA, USA).
T19184 40506-40507 . denotes .
T19183 40496-40506 NNS denotes antibodies
T19182 40492-40495 DT denotes the
T19181 40487-40491 IN denotes with
T19180 40475-40486 NNS denotes incubations
T19179 40471-40474 IN denotes for
T19178 40462-40465 VBD denotes was
T19177 40451-40455 NN denotes goat
T19176 40456-40461 NN denotes serum
T19175 40449-40450 NN denotes %
T19174 40448-40449 CD denotes 2
T19173 40443-40447 CC denotes plus
T19172 40466-40470 VBN denotes used
T19171 40440-40441 HYPH denotes -
T19170 40441-40442 NN denotes T
T19169 40437-40440 NN denotes PBS
T19168 40433-40436 CC denotes and
T19167 40431-40433 , denotes ,
T19166 40430-40431 -RRB- denotes )
T19165 40427-40430 NNP denotes USA
T19164 40425-40427 , denotes ,
T19163 40415-40425 NNP denotes Burlingame
T19162 40413-40414 : denotes ;
T19161 40407-40413 NNP denotes Vector
T19160 40405-40407 , denotes ,
T19159 40402-40405 NNP denotes DBA
T19158 40401-40402 -LRB- denotes (
T19157 40382-40390 NN denotes biflorus
T19156 40373-40381 NNP denotes Dilichos
T19155 40391-40400 NN denotes aggutinin
T19154 40361-40362 HYPH denotes -
T19153 40362-40372 VBN denotes conjugated
T19152 40350-40361 NN denotes fluoroscein
T19151 40345-40349 IN denotes with
T19150 40337-40344 NNS denotes tissues
T19149 40333-40336 DT denotes the
T19148 40330-40332 IN denotes of
T19147 40318-40329 NNS denotes incubations
T19146 40314-40317 IN denotes for
T19145 40305-40308 VBD denotes was
T19144 40309-40313 VBN denotes used
T19143 40302-40303 HYPH denotes -
T19142 40303-40304 NN denotes T
T19141 40299-40302 NN denotes PBS
T19140 40298-40507 sentence denotes PBS-T was used for incubations of the tissues with fluoroscein-conjugated Dilichos biflorus aggutinin (DBA, Vector; Burlingame, USA), and PBS-T plus 2% goat serum was used for incubations with the antibodies.
T19139 40297-40298 . denotes .
T19138 40287-40297 NNS denotes antibodies
T19137 40283-40286 CC denotes and
T19136 40275-40282 NNS denotes lectins
T19135 40270-40274 IN denotes with
T19134 40260-40269 NN denotes treatment
T19133 40257-40259 IN denotes to
T19132 40251-40256 JJ denotes prior
T19131 40249-40250 -RRB- denotes )
T19130 40247-40248 HYPH denotes -
T19129 40248-40249 NN denotes T
T19128 40244-40247 NN denotes PBS
T19127 40243-40244 -LRB- denotes (
T19126 40240-40242 CD denotes 20
T19125 40239-40240 HYPH denotes -
T19124 40234-40239 NN denotes Tween
T19123 40223-40233 VBG denotes containing
T19122 40219-40222 NN denotes PBS
T19121 40214-40218 IN denotes with
T19120 40207-40213 VBN denotes washed
T19119 40203-40206 CC denotes and
T19118 40201-40203 , denotes ,
T19117 40193-40201 NN denotes methanol
T19116 40188-40192 IN denotes with
T19115 40180-40187 VBN denotes treated
T19114 40178-40180 , denotes ,
T19113 40162-40178 NN denotes paraformaldehyde
T19112 40159-40161 IN denotes in
T19363 41281-41285 DT denotes each
T19362 41276-41280 IN denotes from
T19361 41272-41275 CD denotes one
T19360 41270-41272 , denotes ,
T19359 41257-41261 VBD denotes were
T19358 41262-41270 VBN denotes obtained
T19357 41243-41244 HYPH denotes -
T19356 41244-41249 NN denotes stack
T19355 41242-41243 NN denotes Z
T19354 41250-41256 NNS denotes series
T19353 41238-41241 CD denotes Two
T19352 41237-41320 sentence denotes Two Z-stack series were obtained, one from each of the two kidneys of each embryo.
T19351 41236-41237 . denotes .
T19350 41234-41236 PRP denotes it
T19349 41231-41233 IN denotes to
T19348 41220-41230 JJ denotes tangential
T19347 41214-41219 NN denotes plane
T19346 41212-41213 DT denotes a
T19345 41209-41211 IN denotes on
T19344 41204-41208 VBD denotes were
T19343 41200-41203 CC denotes and
T19342 41193-41199 NN denotes kidney
T19341 41189-41192 DT denotes the
T19340 41186-41188 IN denotes of
T19339 41178-41185 NN denotes surface
T19338 41174-41177 DT denotes the
T19337 41171-41173 IN denotes at
T19336 41165-41170 VBD denotes began
T19335 41156-41164 NNS denotes sections
T19334 41152-41155 DT denotes The
T19333 41151-41237 sentence denotes The sections began at the surface of the kidney and were on a plane tangential to it.
T19332 41150-41151 . denotes .
T19331 41148-41150 NN denotes μm
T19330 41139-41144 RBS denotes least
T19329 41145-41147 CD denotes 65
T19328 41136-41138 RB denotes at
T19327 41133-41135 IN denotes of
T19326 41127-41132 NN denotes depth
T19325 41125-41126 DT denotes a
T19324 41122-41124 IN denotes to
T19323 41117-41118 CD denotes 5
T19322 41119-41121 NN denotes μm
T19321 41111-41116 DT denotes every
T19320 41097-41101 VBD denotes were
T19319 41091-41096 NN denotes thick
T19318 41088-41090 NN denotes μm
T19317 41086-41087 CD denotes 2
T19316 41072-41085 RB denotes approximately
T19315 41102-41110 VBN denotes obtained
T19314 41063-41071 NNS denotes sections
T19313 41055-41062 JJ denotes Optical
T19312 41054-41151 sentence denotes Optical sections approximately 2 μm thick were obtained every 5 μm to a depth of at least 65 μm.
T19311 41053-41054 . denotes .
T19310 41052-41053 -RRB- denotes )
T19309 41050-41052 NN denotes nm
T19308 41046-41049 CD denotes 633
T19307 41042-41045 CC denotes and
T19306 41035-41038 CD denotes 543
T19305 41039-41041 NN denotes nm
T19304 41034-41035 -LRB- denotes (
T19303 41027-41033 NNS denotes lasers
T19302 41022-41026 NN denotes HeNe
T19301 41018-41021 CD denotes two
T19300 41014-41017 CC denotes and
T19299 41012-41013 -RRB- denotes )
T19298 41006-41009 CD denotes 488
T19297 41010-41012 NN denotes nm
T19296 41005-41006 -LRB- denotes (
T19295 40999-41004 NN denotes argon
T19294 40996-40998 CD denotes an
T19293 40991-40995 IN denotes with
T19292 40982-40990 VBN denotes equipped
T19291 40980-40981 -RRB- denotes )
T19290 40977-40980 NNP denotes USA
T19289 40975-40977 , denotes ,
T19288 40971-40975 NNP denotes York
T19287 40967-40970 NNP denotes New
T19286 40965-40967 , denotes ,
T19285 40956-40965 NNP denotes Thornwood
T19284 40954-40956 , denotes ,
T19283 40944-40948 NNP denotes Carl
T19282 40949-40954 NNP denotes Zeiss
T19281 40943-40944 -LRB- denotes (
T19280 40923-40931 NN denotes scanning
T19279 40917-40922 NN denotes laser
T19278 40932-40942 NN denotes microscope
T19277 40915-40916 DT denotes a
T19276 40910-40914 IN denotes with
T19275 40898-40902 VBD denotes were
T19274 40903-40909 VBN denotes imaged
T19273 40890-40897 NNS denotes tissues
T19272 40886-40889 DT denotes The
T19271 40885-41054 sentence denotes The tissues were imaged with a laser scanning microscope (Carl Zeiss, Thornwood, New York, USA) equipped with an argon (488 nm) and two HeNe lasers (543 nm and 633 nm).
T19270 40884-40885 . denotes .
T19269 40883-40884 -RRB- denotes )
T19268 40880-40883 NNP denotes USA
T19267 40878-40880 , denotes ,
T19266 40876-40878 NNP denotes OR
T19265 40874-40876 , denotes ,
T19264 40868-40874 NNP denotes Eugene
T19263 40866-40868 , denotes ,
T19262 40850-40859 NNP denotes Molecular
T19261 40860-40866 NNP denotes Probes
T19260 40849-40850 -LRB- denotes (
T19259 40829-40837 JJ denotes anti-rat
T19258 40817-40818 HYPH denotes -
T19257 40814-40817 CD denotes 633
T19256 40818-40828 VBN denotes conjugated
T19255 40808-40813 NNP denotes Alexa
T19254 40804-40807 CC denotes and
T19253 40838-40848 NNS denotes antibodies
T18523 40033-40107 sentence denotes The noon of the day that vaginal plugs were observed was designated E0.5.
T18522 40032-40033 . denotes .
T18521 40010-40032 NN denotes GCCCTCCCCGACGTTTATATTG
T18520 40008-40009 NN denotes R
T18519 40006-40008 , denotes ,
T18518 39980-40006 NN denotes AAGCGTGCCTCATCTCCATCCCTAAG
T18517 39978-39979 NN denotes F
T18516 39976-39978 , denotes ,
T18515 39963-39969 VBN denotes floxed
T18514 39960-39962 CC denotes or
T18513 39957-39959 NN denotes WT
T18512 39970-39976 NN denotes allele
T18511 39951-39956 NN denotes Pygo1
T18510 39949-39950 : denotes ;
T18509 39927-39928 HYPH denotes -
T18508 39926-39927 SYM denotes '
T18507 39928-39949 NN denotes CACTTCTGCCCCTCTCTTTGC
T18506 39925-39926 CD denotes 5
T18505 39923-39924 NN denotes R
T18504 39921-39923 , denotes ,
T18503 39896-39921 NN denotes AGTTTGAAATAGCGACGAGTTTGAG
T18502 39894-39895 NN denotes F
T18501 39892-39894 , denotes ,
T18500 39886-39892 NN denotes allele
T18499 39881-39885 JJ denotes null
T18498 39875-39880 NN denotes Pygo1
T18497 39873-39874 : denotes ;
T18496 39849-39873 NN denotes AGATTCAGTAAGCTGAGCCTGGTG
T18495 39847-39848 NN denotes R
T18494 39845-39847 , denotes ,
T18493 39822-39845 NN denotes TGTCTTGATGACAGCGTTTAGCC
T18492 39820-39821 NN denotes F
T18491 39818-39820 , denotes ,
T18490 39805-39811 VBN denotes floxed
T18489 39802-39804 CC denotes or
T18488 39799-39801 NN denotes WT
T18487 39812-39818 NN denotes allele
T18486 39793-39798 NN denotes Pygo2
T18485 39791-39792 : denotes ;
T18484 39767-39768 -RRB- denotes )
T18483 39766-39767 NN denotes R
T18482 39765-39766 -LRB- denotes (
T18481 39769-39791 NN denotes AAGGTATTTGGTGCTCCGAGGG
T18480 39757-39764 RB denotes reverse
T18479 39755-39756 : denotes ;
T18478 39730-39731 -RRB- denotes )
T18477 39729-39730 NN denotes F
T18476 39728-39729 -LRB- denotes (
T18475 39732-39755 NN denotes CCTGGATTCTTGTTGCTGGTATG
T18474 39720-39727 RB denotes forward
T18473 39718-39720 , denotes ,
T18472 39712-39718 NN denotes allele
T18471 39707-39711 JJ denotes null
T18470 39701-39706 NN denotes Pygo2
T18469 39699-39701 : denotes :
T18468 39691-39694 NN denotes PCR
T18467 39680-39690 VBG denotes genotyping
T18466 39676-39679 IN denotes for
T18465 39671-39675 VBN denotes used
T18464 39663-39670 NNS denotes primers
T18463 39659-39662 DT denotes the
T18462 39656-39658 IN denotes of
T18461 39695-39699 VBD denotes were
T18460 39646-39655 NNS denotes sequences
T18459 39642-39645 DT denotes The
T18458 39641-40033 sentence denotes The sequences of the primers used for genotyping PCR were: Pygo2 null allele, forward (F) CCTGGATTCTTGTTGCTGGTATG; reverse (R) AAGGTATTTGGTGCTCCGAGGG; Pygo2 WT or floxed allele, F TGTCTTGATGACAGCGTTTAGCC, R AGATTCAGTAAGCTGAGCCTGGTG; Pygo1 null allele, F AGTTTGAAATAGCGACGAGTTTGAG, R 5'-CACTTCTGCCCCTCTCTTTGC; Pygo1 WT or floxed allele, F AAGCGTGCCTCATCTCCATCCCTAAG, R GCCCTCCCCGACGTTTATATTG.
T18457 39640-39641 . denotes .
T18456 39639-39640 -RRB- denotes ]
T18455 39637-39639 CD denotes 15
T18454 39636-39637 -LRB- denotes [
T18453 39626-39627 HYPH denotes -
T18452 39627-39630 NN denotes Cre
T18451 39623-39626 NN denotes CMV
T18450 39631-39635 NNS denotes mice
T18449 39619-39622 DT denotes the
T18448 39614-39618 IN denotes with
T18447 39602-39608 VBN denotes floxed
T18446 39609-39613 NNS denotes mice
T18445 39589-39601 JJ denotes heterozygous
T18444 39582-39588 VBG denotes mating
T18443 39579-39581 IN denotes by
T18442 39564-39568 VBD denotes were
T18441 39558-39563 NN denotes Pygo2
T18440 39554-39557 CC denotes and
T18439 39548-39553 NN denotes Pygo1
T18438 39543-39547 CC denotes both
T18437 39540-39542 IN denotes of
T18436 39569-39578 VBN denotes generated
T18435 39527-39531 JJ denotes null
T18434 39532-39539 NNS denotes alleles
T18433 39518-39526 NN denotes Germline
T18432 39517-39641 sentence denotes Germline null alleles of both Pygo1 and Pygo2 were generated by mating heterozygous floxed mice with the CMV-Cre mice [15].
T18431 39516-39517 . denotes .
T18430 39494-39499 NNP denotes Swiss
T18429 39493-39494 HYPH denotes /
T18428 39500-39505 NNP denotes Black
T18427 39490-39493 CD denotes 129
T18426 39484-39489 VBN denotes mixed
T18425 39506-39516 NN denotes background
T18424 39482-39483 DT denotes a
T18423 39479-39481 IN denotes on
T18422 39468-39478 VBN denotes maintained
T18421 39452-39460 VBN denotes targeted
T18420 39461-39467 NNS denotes stocks
T18347 38971-38972 : denotes ;
T18346 38947-38949 , denotes ,
T18345 38949-38971 NN denotes TGTGTAGAACAGAGATTTGGTG
T18344 38938-38939 SYM denotes '
T18343 38940-38947 JJ denotes forward
T18342 38937-38938 CD denotes 3
T18341 38935-38936 : denotes ;
T18340 38911-38913 , denotes ,
T18339 38913-38935 NN denotes TCACCAAATCTCTGTTCTACAC
T18338 38907-38911 JJ denotes back
T18337 38902-38906 NN denotes exon
T18336 38900-38901 : denotes ;
T18335 38878-38880 , denotes ,
T18334 38880-38900 NN denotes GGTTAGGGTCTATGTGCTGG
T18333 38871-38878 JJ denotes forward
T18332 38866-38870 NN denotes exon
T18331 38864-38865 : denotes ;
T18330 38841-38843 , denotes ,
T18329 38843-38864 NN denotes TAGACCCTAACCACCTACAAG
T18328 38835-38836 SYM denotes '
T18327 38837-38841 JJ denotes back
T18326 38834-38835 CD denotes 5
T18325 38832-38833 : denotes ;
T18324 38806-38808 , denotes ,
T18323 38808-38832 NN denotes GTGAAGGAGAGATGGATAAGTATG
T18322 38797-38798 SYM denotes '
T18321 38799-38806 JJ denotes forward
T18320 38796-38797 CD denotes 5
T18319 38794-38796 : denotes :
T18318 38786-38789 NN denotes PCR
T18317 38782-38785 IN denotes for
T18316 38777-38781 VBN denotes used
T18315 38759-38766 JJ denotes genomic
T18314 38767-38776 NNS denotes sequences
T18313 38755-38758 DT denotes the
T18312 38753-38755 , denotes ,
T18311 38748-38753 NN denotes Pygo1
T18310 38790-38794 VBD denotes were
T18309 38744-38747 IN denotes For
T18308 38743-39003 sentence denotes For Pygo1, the genomic sequences used for PCR were: 5' forward, GTGAAGGAGAGATGGATAAGTATG; 5' back, TAGACCCTAACCACCTACAAG; exon forward, GGTTAGGGTCTATGTGCTGG; exon back, TCACCAAATCTCTGTTCTACAC; 3' forward, TGTGTAGAACAGAGATTTGGTG; 3' back, CAGTGAAGAAAGAGGGTCAG.
T18307 38742-38743 . denotes .
T18306 38732-38742 NN denotes sequencing
T18305 38729-38731 IN denotes by
T18304 38714-38718 VBD denotes were
T18303 38719-38728 VBN denotes confirmed
T18302 38693-38702 NN denotes targeting
T18301 38683-38692 VBG denotes resulting
T18300 38703-38713 NNS denotes constructs
T18299 38679-38682 DT denotes The
T18298 38678-38743 sentence denotes The resulting targeting constructs were confirmed by sequencing.
T18297 38677-38678 . denotes .
T18296 38669-38673 NN denotes cell
T18295 38666-38668 NN denotes ES
T18294 38674-38677 NN denotes DNA
T18293 38663-38665 NN denotes RI
T18292 38658-38662 IN denotes from
T18291 38654-38657 NN denotes PCR
T18290 38651-38653 IN denotes by
T18289 38641-38645 VBD denotes were
T18288 38630-38640 NN denotes subcloning
T18287 38626-38629 IN denotes for
T18286 38617-38625 VBN denotes required
T18285 38600-38607 JJ denotes genomic
T18284 38594-38599 CD denotes three
T18283 38608-38616 NNS denotes segments
T18282 38590-38593 DT denotes the
T18281 38588-38590 , denotes ,
T18280 38579-38588 NN denotes construct
T18279 38574-38578 DT denotes each
T18278 38646-38650 VBN denotes made
T18277 38570-38573 IN denotes For
T18276 38569-38678 sentence denotes For each construct, the three genomic segments required for subcloning were made by PCR from RI ES cell DNA.
T18275 38568-38569 . denotes .
T18274 38559-38568 NNS denotes sequences
T18273 38554-38558 NN denotes LoxP
T18272 38551-38553 IN denotes by
T18271 38540-38542 VB denotes be
T18270 38543-38550 VBN denotes flanked
T18269 38537-38539 TO denotes to
T18268 38521-38529 JJ denotes critical
T18267 38530-38536 NN denotes region
T18266 38517-38520 DT denotes the
T18265 38513-38516 CC denotes and
T18264 38511-38513 , denotes ,
T18263 38498-38511 NN denotes recombination
T18262 38490-38497 VBG denotes driving
T18261 38486-38489 IN denotes for
T18260 38477-38485 NN denotes homology
T18259 38474-38476 IN denotes of
T18258 38463-38466 CD denotes two
T18257 38467-38473 NNS denotes blocks
T18256 38459-38462 DT denotes the
T18255 38448-38458 VBG denotes subcloning
T18254 38444-38447 IN denotes for
T18253 38426-38437 NN denotes restriction
T18252 38419-38425 JJ denotes unique
T18251 38438-38443 NNS denotes sites
T18250 38413-38418 CD denotes three
T18249 38409-38412 CC denotes and
T18248 38407-38409 , denotes ,
T18247 38398-38407 NNS denotes sequences
T18246 38394-38397 NN denotes FRT
T18245 38391-38393 IN denotes by
T18244 38383-38390 VBN denotes flanked
T18243 38366-38367 HYPH denotes -
T18242 38367-38377 NN denotes resistance
T18241 38358-38366 NN denotes neomycin
T18240 38378-38382 NN denotes gene
T18239 38356-38357 DT denotes a
T18238 38348-38355 VBZ denotes carries
T18237 38342-38347 WDT denotes which
T18236 38340-38342 , denotes ,
T18235 38339-38340 -RRB- denotes ]
T18234 38337-38339 CD denotes 34
T18233 38336-38337 -LRB- denotes [
T18232 38326-38335 VBN denotes described
T18231 38315-38325 RB denotes previously
T18230 38303-38304 HYPH denotes /
T18229 38304-38307 NN denotes Cre
T18228 38300-38303 NN denotes Flp
T18227 38308-38314 NN denotes vector
T18226 38296-38299 DT denotes the
T18225 38290-38295 VBG denotes using
T18224 38280-38284 VBD denotes were
T18223 38285-38289 VBN denotes made
T18222 38269-38279 NNS denotes constructs
T18221 38259-38268 NN denotes Targeting
T18220 38258-38569 sentence denotes Targeting constructs were made using the Flp/Cre vector previously described [34], which carries a neomycin-resistance gene flanked by FRT sequences, and three unique restriction sites for subcloning the two blocks of homology for driving recombination, and the critical region to be flanked by LoxP sequences.
T18219 38257-38258 . denotes .
T18218 38248-38257 NNS denotes sequences
T18217 38243-38247 NN denotes LoxP
T18216 38238-38242 IN denotes with
T18215 38228-38231 NN denotes PHD
T18214 38232-38237 NN denotes motif
T18213 38224-38227 DT denotes the
T18212 38213-38223 VBG denotes containing
T18211 38202-38207 JJ denotes third
T18210 38208-38212 NN denotes exon
T18209 38198-38201 DT denotes the
T18208 38195-38197 IN denotes of
T18207 38180-38186 NN denotes coding
T18206 38171-38179 JJ denotes critical
T18205 38187-38194 NNS denotes regions
T18204 38167-38170 DT denotes the
T18203 38158-38166 VBG denotes flanking
T18202 38155-38157 IN denotes by
T18201 38141-38145 RB denotes each
T18200 38136-38140 VBD denotes were
T18199 38146-38154 VBN denotes targeted
T18198 38124-38129 NN denotes Pygo2
T18197 38120-38123 CC denotes and
T18196 38130-38135 NNS denotes genes
T18195 38114-38119 NN denotes Pygo1
T18194 38113-38258 sentence denotes Pygo1 and Pygo2 genes were each targeted by flanking the critical coding regions of the third exon containing the PHD motif with LoxP sequences.
T18193 38108-38113 NN denotes Pygo2
T18192 38104-38107 CC denotes and
T18191 38098-38103 NN denotes Pygo1
T18190 38095-38097 IN denotes of
T18189 38085-38094 NN denotes Targeting
T18419 39448-39451 DT denotes the
T18418 39444-39447 CC denotes and
T18417 39442-39444 , denotes ,
T18416 39438-39442 NNS denotes mice
T18415 39432-39437 NNP denotes Black
T18414 39426-39431 NNP denotes Swiss
T18413 39421-39425 IN denotes with
T18412 39410-39414 VBD denotes were
T18411 39415-39420 VBN denotes mated
T18410 39401-39409 NNS denotes chimeras
T18409 39391-39400 VBG denotes Resulting
T18408 39390-39517 sentence denotes Resulting chimeras were mated with Swiss Black mice, and the targeted stocks maintained on a mixed 129/Swiss Black background.
T18407 39389-39390 . denotes .
T18406 39380-39389 NNS denotes protocols
T18405 39371-39379 JJ denotes standard
T18404 39368-39370 IN denotes to
T18403 39358-39367 VBG denotes according
T18402 39336-39346 NN denotes blastocyst
T18401 39347-39357 NNS denotes injections
T18400 39331-39332 HYPH denotes /
T18399 39332-39335 NN denotes Bl6
T18398 39328-39331 NN denotes C57
T18397 39324-39327 IN denotes for
T18396 39319-39323 VBN denotes used
T18395 39310-39312 NN denotes ES
T18394 39301-39309 VBN denotes targeted
T18393 39313-39318 NNS denotes cells
T18392 39291-39300 VBG denotes resulting
T18391 39287-39290 CC denotes and
T18390 39285-39287 , denotes ,
T18389 39277-39279 NN denotes ES
T18388 39280-39285 NNS denotes cells
T18387 39274-39276 NN denotes RI
T18386 39269-39273 IN denotes into
T18385 39249-39253 VBD denotes were
T18384 39254-39268 VBN denotes electroporated
T18383 39238-39248 NNS denotes constructs
T18382 39227-39237 VBN denotes Linearized
T18381 39226-39390 sentence denotes Linearized constructs were electroporated into RI ES cells, and resulting targeted ES cells used for C57/Bl6 blastocyst injections according to standard protocols.
T18380 39225-39226 . denotes .
T18379 39204-39225 NN denotes CAACAACAACAGAAGACAAGC
T18378 39200-39203 CC denotes and
T18377 39180-39199 NN denotes TGGGTGCTGGGAACAGAAC
T18376 39170-39179 NNS denotes sequences
T18375 39165-39169 NN denotes exon
T18374 39161-39164 CC denotes and
T18373 39159-39161 , denotes ,
T18372 39139-39159 NN denotes CCAGTCATACCAGCAACAAG
T18371 39135-39138 CC denotes and
T18370 39113-39134 NN denotes CCAAGTCCCAGCATCTCTTAC
T18369 39111-39113 , denotes ,
T18368 39082-39111 NN denotes CCACCTTACTTGTGTGTGAGGATACATAC
T18367 39078-39081 CC denotes and
T18366 39056-39077 NN denotes GCCTGGGTTGCTTGTCTTCTG
T18365 39054-39056 : denotes :
T18364 39046-39049 NN denotes PCR
T18363 39042-39045 IN denotes for
T18362 39037-39041 VBN denotes used
T18361 39019-39026 JJ denotes genomic
T18360 39027-39036 NNS denotes sequences
T18359 39015-39018 DT denotes the
T18358 39013-39015 , denotes ,
T18357 39008-39013 NN denotes Pygo2
T18356 39050-39054 VBD denotes were
T18355 39004-39007 IN denotes For
T18354 39003-39226 sentence denotes For Pygo2, the genomic sequences used for PCR were: GCCTGGGTTGCTTGTCTTCTG and CCACCTTACTTGTGTGTGAGGATACATAC, CCAAGTCCCAGCATCTCTTAC and CCAGTCATACCAGCAACAAG, and exon sequences TGGGTGCTGGGAACAGAAC and CAACAACAACAGAAGACAAGC.
T18353 39002-39003 . denotes .
T18352 38980-38982 , denotes ,
T18351 38982-39002 NN denotes CAGTGAAGAAAGAGGGTCAG
T18350 38974-38975 SYM denotes '
T18349 38976-38980 JJ denotes back
T18348 38973-38974 CD denotes 3
T17417 38060-38062 VB denotes be
T17416 38063-38073 VBN denotes determined
T17415 38057-38059 TO denotes to
T17414 38034-38043 JJ denotes redundant
T17413 38026-38033 NN denotes Pygopus
T17412 38044-38049 NNS denotes genes
T17411 38020-38025 DT denotes these
T17410 38017-38019 IN denotes of
T17409 38011-38016 NNS denotes roles
T17408 38007-38010 CC denotes and
T17407 38050-38056 VBP denotes remain
T17406 37996-38006 NNS denotes identities
T17405 37992-37995 DT denotes The
T17404 37991-38074 sentence denotes The identities and roles of these Pygopus redundant genes remain to be determined.
T17403 37990-37991 . denotes .
T17402 37983-37990 NNS denotes mammals
T17401 37980-37982 IN denotes in
T17400 37973-37974 HYPH denotes /
T17399 37974-37979 NN denotes Pygo2
T17398 37968-37973 NN denotes Pygo1
T17397 37965-37967 IN denotes of
T17396 37944-37954 NN denotes activation
T17395 37930-37943 NN denotes transcription
T17394 37927-37929 CC denotes or
T17393 37926-37927 HYPH denotes /
T17392 37923-37926 CC denotes and
T17391 37910-37922 NN denotes localization
T17390 37902-37909 JJ denotes nuclear
T17389 37955-37964 NNS denotes functions
T17388 37898-37901 DT denotes the
T17387 37888-37891 MD denotes may
T17382 37872-37874 , denotes ,
T17381 37863-37871 NN denotes proteins
T17380 37860-37862 IN denotes of
T17379 37845-37852 VBG denotes growing
T17378 37841-37844 CC denotes and
T17377 37835-37840 JJ denotes large
T17376 37853-37859 NN denotes number
T17375 37833-37834 DT denotes a
T17374 37824-37832 VBZ denotes includes
T17373 37808-37809 HYPH denotes -
T17372 37809-37815 NN denotes factor
T17371 37795-37808 NN denotes transcription
T17370 37786-37787 HYPH denotes -
T17369 37787-37794 NN denotes catenin
T17368 37785-37786 NN denotes β
T17367 37816-37823 NN denotes complex
T17366 37781-37784 DT denotes The
T17365 37780-37991 sentence denotes The β-catenin transcription-factor complex includes a large and growing number of proteins , some of which may share the nuclear localization and/or transcription activation functions of Pygo1/Pygo2 in mammals.
T17364 37779-37780 . denotes .
T17363 37766-37773 NN denotes Pygopus
T17362 37762-37765 CD denotes two
T17361 37774-37779 NNS denotes genes
T17360 37758-37761 DT denotes the
T17359 37753-37757 IN denotes with
T17358 37731-37741 JJ denotes functional
T17357 37742-37752 NN denotes redundancy
T17356 37723-37730 JJ denotes partial
T17355 37712-37717 NNS denotes genes
T17354 37706-37711 JJ denotes other
T17353 37704-37706 , denotes ,
T17352 37697-37704 NNS denotes mammals
T17351 37694-37696 IN denotes in
T17350 37718-37722 VBP denotes show
T17349 37689-37693 IN denotes that
T17348 37665-37673 JJS denotes simplest
T17347 37674-37685 NN denotes explanation
T17346 37661-37664 DT denotes the
T17345 37686-37688 VBZ denotes is
T17344 37653-37660 RB denotes Perhaps
T17343 37652-37780 sentence denotes Perhaps the simplest explanation is that in mammals, other genes show partial functional redundancy with the two Pygopus genes.
T17342 37651-37652 . denotes .
T17341 37644-37651 NNS denotes mutants
T17340 37636-37643 NNP denotes Pygopus
T17339 37633-37635 IN denotes in
T17338 37626-37632 JJ denotes intact
T17337 37603-37616 NN denotes organogenesis
T17336 37593-37602 JJ denotes mammalian
T17335 37591-37593 , denotes ,
T17334 37584-37591 JJ denotes general
T17333 37617-37625 VBD denotes remained
T17332 37581-37583 IN denotes in
T17331 37577-37580 CC denotes but
T17330 37575-37577 , denotes ,
T17329 37565-37566 HYPH denotes -
T17328 37566-37575 JJ denotes dependent
T17327 37558-37565 NN denotes context
T17326 37544-37553 NN denotes signaling
T17325 37540-37543 NN denotes Wnt
T17324 37537-37539 IN denotes in
T17323 37529-37530 CD denotes 2
T17322 37528-37529 HYPH denotes /
T17321 37524-37528 NN denotes Pyg1
T17320 37531-37536 NNS denotes genes
T17319 37520-37523 DT denotes the
T17318 37517-37519 IN denotes of
T17317 37506-37516 NN denotes importance
T17316 37503-37505 IN denotes of
T17315 37554-37557 VBD denotes was
T17314 37496-37502 NN denotes degree
T17313 37492-37495 DT denotes The
T17312 37491-37652 sentence denotes The degree of importance of the Pyg1/2 genes in Wnt signaling was context-dependent, but in general, mammalian organogenesis remained intact in Pygopus mutants.
T17311 37490-37491 . denotes .
T17310 37480-37490 NNP denotes Drosophila
T17309 37477-37479 IN denotes in
T17308 37472-37476 IN denotes than
T17307 37465-37471 JJR denotes milder
T17306 37460-37464 RB denotes much
T17305 37447-37455 NN denotes mutation
T17304 37439-37446 NN denotes Pygopus
T17303 37436-37438 IN denotes of
T17302 37417-37427 JJ denotes phenotypic
T17301 37428-37435 NNS denotes effects
T17300 37413-37416 DT denotes the
T17299 37411-37413 , denotes ,
T17298 37404-37411 RB denotes however
T17297 37402-37404 , denotes ,
T17296 37395-37402 NNS denotes mammals
T17295 37456-37459 VBP denotes are
T17294 37392-37394 IN denotes In
T17293 37391-37491 sentence denotes In mammals, however, the phenotypic effects of Pygopus mutation are much milder than in Drosophila.
T17292 37390-37391 . denotes .
T17291 37377-37380 NN denotes Wnt
T17290 37381-37390 NN denotes signaling
T17289 37367-37376 JJ denotes canonical
T17288 37364-37366 IN denotes in
T17287 37345-37354 VBN denotes conserved
T17286 37330-37344 RB denotes evolutionarily
T17285 37355-37363 NN denotes function
T17284 37327-37329 DT denotes an
T17283 37316-37318 VBP denotes do
T17282 37314-37316 , denotes ,
T17281 37308-37314 NN denotes report
T17280 37303-37307 DT denotes this
T17279 37300-37302 IN denotes in
T17278 37290-37299 VBN denotes described
T17277 37276-37284 NN denotes knockout
T17276 37269-37270 HYPH denotes /
T17275 37270-37275 NN denotes Pygo2
T17274 37264-37269 NN denotes Pygo1
T17273 37285-37289 NNS denotes mice
T17272 37260-37263 DT denotes the
T17271 37257-37259 IN denotes in
T17270 37237-37245 NN denotes reporter
T17269 37227-37236 NN denotes transgene
T17268 37222-37223 HYPH denotes -
T17267 37223-37226 NN denotes gal
T17266 37219-37222 NN denotes BAT
T17265 37211-37218 VBN denotes reduced
T17264 37246-37256 NN denotes expression
T17263 37207-37210 DT denotes the
T17262 37203-37206 CC denotes and
T17261 37201-37202 -RRB- denotes ]
T17260 37198-37199 , denotes ,
T17259 37196-37198 CD denotes 32
T17258 37199-37201 CD denotes 33
T17257 37195-37196 -LRB- denotes [
T17256 37319-37326 VB denotes confirm
T17255 37179-37186 NN denotes culture
T17254 37174-37178 NN denotes cell
T17253 37187-37194 NNS denotes studies
T17252 37165-37173 JJ denotes Previous
T17251 37164-37391 sentence denotes Previous cell culture studies [32,33] and the reduced BAT-gal transgene reporter expression in the Pygo1/Pygo2 knockout mice described in this report, do confirm an evolutionarily conserved function in canonical Wnt signaling.
T17250 37163-37164 . denotes .
T17249 37154-37163 NN denotes signaling
T17248 37150-37153 NN denotes Wnt
T17247 37147-37149 IN denotes of
T17246 37122-37134 JJ denotes quantitative
T17245 37135-37146 NNS denotes transducers
T17244 37117-37121 RB denotes only
T17243 37115-37117 , denotes ,
T17242 37097-37107 VBG denotes developing
T17241 37108-37115 NNS denotes systems
T17240 37092-37096 JJS denotes most
T17239 37089-37091 IN denotes in
T17238 37087-37089 , denotes ,
T17237 37070-37077 NN denotes Pygopus
T17236 37060-37069 JJ denotes mammalian
T17235 37078-37083 NNS denotes genes
T17234 37056-37059 DT denotes the
T17233 37084-37087 VBP denotes are
T17232 37051-37055 IN denotes that
T17231 37045-37050 VBP denotes argue
T17230 37037-37044 NNS denotes results
T17229 37033-37036 DT denotes The
T17228 37032-37164 sentence denotes The results argue that the mammalian Pygopus genes are, in most developing systems, only quantitative transducers of Wnt signaling.
T17227 37031-37032 . denotes .
T17226 37018-37031 NN denotes nephrogenesis
T17225 37015-37017 IN denotes in
T17224 37001-37004 NN denotes Wnt
T17223 37005-37014 NN denotes signaling
T17222 36991-37000 JJ denotes canonical
T17221 36988-36990 IN denotes of
T17220 36977-36987 NN denotes importance
T17219 36973-36976 DT denotes the
T17218 36969-36972 CC denotes and
T17217 36967-36969 , denotes ,
T17216 36957-36967 NNP denotes Drosophila
T17215 36954-36956 IN denotes in
T17214 36940-36943 NN denotes Wnt
T17213 36944-36953 NN denotes signaling
T17212 36930-36939 JJ denotes canonical
T17211 36927-36929 IN denotes in
T17210 36914-36921 NN denotes Pygopus
T17209 36922-36926 NN denotes gene
T17208 36910-36913 DT denotes the
T17207 36907-36909 IN denotes of
T17206 36896-36906 NN denotes importance
T17205 36892-36895 DT denotes the
T17204 36880-36891 VBG denotes considering
T17203 36869-36879 JJ denotes surprising
T17202 36865-36868 VBD denotes was
T17201 36860-36864 DT denotes This
T17200 36859-37032 sentence denotes This was surprising considering the importance of the Pygopus gene in canonical Wnt signaling in Drosophila, and the importance of canonical Wnt signaling in nephrogenesis.
T17199 36858-36859 . denotes .
T17198 36851-36858 NNS denotes mutants
T17197 36839-36840 HYPH denotes -
T17196 36833-36839 JJ denotes double
T17195 36840-36850 JJ denotes homozygous
T17194 36826-36827 HYPH denotes /
T17193 36827-36832 NN denotes Pygo2
T17192 36821-36826 NN denotes Pygo1
T17191 36818-36820 IN denotes in
T17190 36813-36817 RB denotes even
T17189 36811-36813 , denotes ,
T17188 36803-36811 RB denotes normally
T17187 36792-36802 RB denotes remarkably
T17186 36772-36781 NN denotes formation
T17185 36764-36771 NN denotes nephron
T17184 36762-36764 , denotes ,
T17183 36782-36791 VBD denotes proceeded
T17182 36750-36762 RB denotes Nevertheless
T17181 36749-36859 sentence denotes Nevertheless, nephron formation proceeded remarkably normally, even in Pygo1/Pygo2 double-homozygous mutants.
T17180 36748-36749 . denotes .
T17179 36735-36743 JJ denotes ureteric
T17178 36744-36748 NNS denotes buds
T17177 36731-36734 DT denotes the
T17176 36726-36730 VBZ denotes caps
T17175 36721-36725 WDT denotes that
T17174 36710-36720 NN denotes mesenchyme
T17173 36698-36709 JJ denotes metanephric
T17172 36695-36697 IN denotes of
T17171 36690-36694 NN denotes zone
T17170 36686-36689 DT denotes the
T17169 36683-36685 IN denotes of
T17168 36673-36682 NN denotes expansion
T17167 36670-36672 DT denotes an
T17386 37882-37887 WDT denotes which
T17385 37879-37881 IN denotes of
T17384 37892-37897 VB denotes share
T17383 37874-37878 DT denotes some
T17166 36660-36665 EX denotes there
T17165 36652-36659 NNS denotes mutants
T17164 36646-36651 NN denotes Pygo2
T17163 36643-36645 IN denotes in
T17162 36641-36643 , denotes ,
T17161 36633-36641 NN denotes addition
T17160 36666-36669 VBD denotes was
T17159 36630-36632 IN denotes In
T17158 36629-36749 sentence denotes In addition, in Pygo2 mutants there was an expansion of the zone of metanephric mesenchyme that caps the ureteric buds.
T17157 36628-36629 . denotes .
T17156 36624-36628 NNS denotes tips
T17155 36621-36623 IN denotes of
T17154 36613-36620 NNS denotes numbers
T17153 36605-36612 VBN denotes reduced
T17152 36601-36604 CC denotes and
T17151 36596-36600 NNS denotes tips
T17150 36588-36595 VBN denotes dilated
T17149 36580-36587 VBG denotes showing
T17148 36572-36579 NNS denotes mutants
T17147 36567-36571 IN denotes with
T17146 36565-36567 , denotes ,
T17145 36553-36561 JJ denotes ureteric
T17144 36562-36565 NN denotes bud
T17143 36549-36552 DT denotes the
T17142 36546-36548 IN denotes of
T17141 36522-36531 NN denotes branching
T17140 36532-36545 NN denotes morphogenesis
T17139 36515-36521 JJ denotes normal
T17138 36511-36514 IN denotes for
T17137 36499-36501 VBZ denotes is
T17136 36488-36493 NN denotes Pygo2
T17135 36478-36487 JJ denotes mammalian
T17134 36494-36498 NN denotes gene
T17133 36474-36477 DT denotes the
T17132 36472-36474 , denotes ,
T17131 36462-36472 NN denotes conclusion
T17130 36502-36510 VBN denotes required
T17129 36459-36461 IN denotes In
T16472 36445-36446 . denotes .
T16471 36432-36435 NN denotes Wnt
T16470 36436-36445 NN denotes signaling
T16469 36422-36431 JJ denotes canonical
T16468 36419-36421 IN denotes of
T16467 36402-36410 JJ denotes complete
T16466 36397-36401 RBR denotes more
T16465 36411-36418 NN denotes removal
T16464 36395-36396 DT denotes a
T16463 36390-36394 IN denotes with
T16462 36372-36382 VBG denotes developing
T16461 36383-36389 NN denotes kidney
T16460 36370-36371 DT denotes a
T16459 36367-36369 IN denotes in
T16458 36361-36366 NN denotes level
T16457 36350-36360 NN denotes expression
T16456 36347-36349 IN denotes in
T16455 36339-36346 NNS denotes changes
T16454 36331-36338 JJR denotes greater
T16453 36326-36330 VB denotes show
T16452 36323-36325 TO denotes to
T16451 36317-36322 NNS denotes genes
T16450 36311-36316 DT denotes these
T16449 36297-36302 MD denotes would
T16448 36303-36310 VB denotes predict
T16447 36294-36296 PRP denotes We
T16416 36108-36110 IN denotes to
T16415 36094-36097 VBP denotes are
T16414 36086-36093 NNS denotes mammals
T16413 36083-36085 IN denotes in
T16412 36069-36076 NN denotes Pygopus
T16411 36077-36082 NNS denotes genes
T16410 36065-36068 DT denotes the
T16409 36098-36107 VBN denotes dedicated
T16408 36060-36064 IN denotes that
T16407 36218-36227 VBP denotes represent
T16406 36051-36059 VBG denotes Assuming
T16405 36050-36293 sentence denotes Assuming that the Pygopus genes in mammals are dedicated to canonical Wnt signaling, as has been previously shown in Drosophila, the genes with expression differences represent candidate Wnt targets (direct or indirect) in kidney development.
T16404 36049-36050 . denotes .
T16403 36031-36041 JJ denotes biological
T16402 36042-36049 NNS denotes samples
T16401 36019-36030 JJ denotes independent
T16400 36014-36018 IN denotes with
T16399 36010-36013 NN denotes PCR
T16398 36004-36005 HYPH denotes -
T16397 36005-36009 NN denotes time
T16396 36000-36004 JJ denotes real
T16395 35997-35999 IN denotes by
T16394 35984-35986 VB denotes be
T16393 35978-35983 MD denotes could
T16392 35966-35977 NNS denotes differences
T16391 35960-35965 DT denotes these
T16390 35957-35959 IN denotes of
T16389 35987-35996 VBN denotes validated
T16388 35941-35945 JJ denotes high
T16387 35946-35956 NN denotes percentage
T16386 35939-35940 DT denotes a
T16385 35935-35938 CC denotes and
T16384 35933-35935 , denotes ,
T16383 35922-35933 NNS denotes differences
T16382 35911-35921 NN denotes expression
T16381 35904-35906 , denotes ,
T16380 35897-35904 RB denotes however
T16379 35895-35897 , denotes ,
T16378 35892-35895 VBD denotes did
T16377 35906-35910 VB denotes show
T16376 35886-35891 NNS denotes genes
T16375 35881-35885 DT denotes Some
T16374 35880-36050 sentence denotes Some genes did, however, show expression differences, and a high percentage of these differences could be validated by real-time PCR with independent biological samples.
T16373 35879-35880 . denotes .
T16372 35875-35879 NN denotes type
T16371 35870-35874 JJ denotes wild
T16370 35867-35869 IN denotes to
T16369 35859-35866 JJ denotes similar
T16368 35846-35858 RB denotes surprisingly
T16367 35837-35845 NNS denotes profiles
T16366 35825-35826 HYPH denotes -
T16365 35826-35836 NN denotes expression
T16364 35821-35825 NN denotes gene
T16363 35799-35805 NN denotes mutant
T16362 35806-35813 NNS denotes kidneys
T16361 35795-35798 DT denotes the
T16360 35793-35795 , denotes ,
T16359 35814-35820 VBD denotes showed
T16358 35780-35793 RB denotes Interestingly
T16357 35779-35880 sentence denotes Interestingly, the mutant kidneys showed gene-expression profiles surprisingly similar to wild type.
T16356 35778-35779 . denotes .
T16355 35773-35778 NNS denotes genes
T16354 35769-35772 DT denotes all
T16353 35766-35768 IN denotes of
T16352 35756-35765 NNS denotes promoters
T16351 35753-35755 IN denotes of
T16350 35737-35745 NN denotes activity
T16349 35746-35752 NNS denotes levels
T16348 35733-35736 DT denotes the
T16347 35730-35732 IN denotes of
T16346 35721-35729 NN denotes analysis
T16345 35717-35720 DT denotes the
T16344 35699-35709 NN denotes microarray
T16343 35695-35698 DT denotes the
T16342 35693-35695 , denotes ,
T16254 35161-35163 IN denotes In
T16253 35160-35268 sentence denotes In addition, the kidneys were not unique in showing surprisingly normal development in Pygo1/Pygo2 mutants.
T16252 35159-35160 . denotes .
T16251 35149-35159 NN denotes diminution
T16250 35146-35148 IN denotes of
T16249 35140-35145 NN denotes level
T16248 35137-35139 IN denotes in
T16247 35127-35136 NN denotes variation
T16246 35117-35118 HYPH denotes -
T16245 35118-35126 JJ denotes specific
T16244 35111-35117 NN denotes tissue
T16243 35106-35110 IN denotes with
T16242 35104-35106 , denotes ,
T16241 35090-35096 NN denotes mutant
T16240 35097-35104 NNS denotes embryos
T16239 35083-35084 HYPH denotes /
T16238 35084-35089 NN denotes Pygo2
T16237 35078-35083 NN denotes Pygo1
T16236 35075-35077 IN denotes in
T16235 35061-35067 JJ denotes absent
T16234 35057-35060 RB denotes not
T16233 35047-35056 RB denotes generally
T16232 35043-35046 CC denotes but
T16231 35068-35074 NN denotes signal
T16230 35035-35042 VBN denotes reduced
T16229 35014-35017 NN denotes Wnt
T16228 35018-35027 NN denotes signaling
T16227 35004-35013 JJ denotes canonical
T16226 35001-35003 IN denotes of
T16225 35028-35034 VBD denotes showed
T16224 34982-34991 NN denotes transgene
T16223 34977-34978 HYPH denotes -
T16222 34978-34981 NN denotes gal
T16221 34974-34977 NN denotes BAT
T16220 34992-35000 NN denotes reporter
T16219 34970-34973 DT denotes The
T16218 34969-35160 sentence denotes The BAT-gal transgene reporter of canonical Wnt signaling showed reduced but generally not absent signal in Pygo1/Pygo2 mutant embryos, with tissue-specific variation in level of diminution.
T16217 34968-34969 . denotes .
T16216 34955-34958 NN denotes Wnt
T16215 34959-34968 NN denotes signaling
T16214 34945-34954 JJ denotes canonical
T16213 34942-34944 IN denotes in
T16212 34929-34936 JJR denotes smaller
T16211 34937-34941 NN denotes role
T16210 34927-34928 DT denotes a
T16209 34922-34926 VB denotes play
T16208 34919-34921 TO denotes to
T16207 34899-34900 HYPH denotes /
T16206 34900-34905 NN denotes Pygo2
T16205 34894-34899 NN denotes Pygo1
T16204 34906-34911 NNS denotes genes
T16203 34890-34893 DT denotes the
T16202 34882-34889 NNS denotes mammals
T16201 34879-34881 IN denotes in
T16200 34912-34918 VBP denotes appear
T16199 34873-34878 IN denotes while
T16198 34871-34873 , denotes ,
T16197 34858-34861 NN denotes Wnt
T16196 34862-34871 NN denotes signaling
T16195 34848-34857 JJ denotes canonical
T16194 34844-34847 IN denotes for
T16193 34829-34834 RB denotes often
T16192 34826-34828 VBZ denotes is
T16191 34813-34820 NN denotes Pygopus
T16190 34821-34825 NN denotes gene
T16189 34809-34812 DT denotes the
T16188 34807-34809 , denotes ,
T16187 34797-34807 NNP denotes Drosophila
T16186 34835-34843 VBN denotes required
T16185 34794-34796 IN denotes In
T16184 34793-34969 sentence denotes In Drosophila, the Pygopus gene is often required for canonical Wnt signaling, while in mammals the Pygo1/Pygo2 genes appear to play a smaller role in canonical Wnt signaling.
T16183 34792-34793 . denotes .
T16182 34785-34792 NNS denotes mammals
T16181 34781-34784 CC denotes and
T16180 34770-34780 NNP denotes Drosophila
T16179 34762-34769 IN denotes between
T16178 34753-34761 NN denotes function
T16177 34745-34752 NN denotes Pygopus
T16176 34742-34744 IN denotes of
T16175 34718-34730 JJ denotes evolutionary
T16174 34707-34717 JJ denotes surprising
T16173 34703-34706 CC denotes and
T16172 34694-34702 JJ denotes striking
T16171 34731-34741 NN denotes divergence
T16170 34692-34693 DT denotes a
T16169 34676-34682 NN denotes report
T16168 34671-34675 DT denotes this
T16167 34668-34670 IN denotes in
T16166 34683-34691 VBP denotes indicate
T16165 34660-34667 NNS denotes results
T16164 34656-34659 DT denotes The
T16163 34655-34793 sentence denotes The results in this report indicate a striking and surprising evolutionary divergence of Pygopus function between Drosophila and mammals.
T16162 34654-34655 . denotes .
T16161 34653-34654 -RRB- denotes ]
T16160 34652-34653 CD denotes 2
T16159 34651-34652 -LRB- denotes [
T16158 34637-34640 NN denotes Wnt
T16157 34641-34650 NN denotes signaling
T16156 34627-34636 JJ denotes canonical
T16155 34623-34626 IN denotes via
T16154 34609-34622 NN denotes nephrogenesis
T16153 34602-34608 VB denotes induce
T16152 34599-34601 TO denotes to
T16151 34588-34592 VBN denotes been
T16150 34584-34587 VBZ denotes has
T16149 34561-34572 JJ denotes metanephric
T16148 34573-34583 NN denotes mesenchyme
T16147 34557-34560 DT denotes the
T16146 34554-34556 IN denotes to
T16145 34541-34549 JJ denotes ureteric
T16144 34550-34553 NN denotes bud
T16143 34537-34540 DT denotes the
T16142 34532-34536 IN denotes from
T16141 34522-34531 NN denotes signaling
T16140 34516-34521 NN denotes Wnt9b
T16139 34593-34598 VBN denotes shown
T16138 34513-34515 IN denotes as
T16137 34511-34513 , denotes ,
T16136 34500-34511 JJ denotes interesting
T16135 34487-34499 RB denotes particularly
T16134 34483-34486 VBD denotes was
T16133 34478-34482 DT denotes This
T16132 34477-34655 sentence denotes This was particularly interesting, as Wnt9b signaling from the ureteric bud to the metanephric mesenchyme has been shown to induce nephrogenesis via canonical Wnt signaling [2].
T16131 34476-34477 . denotes .
T16130 34468-34476 RB denotes normally
T16129 34459-34467 NNS denotes nephrons
T16128 34429-34440 JJ denotes metanephric
T16126 34441-34451 NN denotes mesenchyme
T16125 34418-34421 DT denotes the
T16124 34416-34418 , denotes ,
T16123 34452-34458 VBD denotes formed
T16122 34404-34416 RB denotes Nevertheless
T16121 34403-34477 sentence denotes Nevertheless, the mutant metanephric mesenchyme formed nephrons normally.
T16120 34402-34403 . denotes .
T16119 34390-34398 JJ denotes ureteric
T16118 34399-34402 NN denotes bud
T16117 34386-34389 DT denotes the
T16116 34381-34385 VBZ denotes caps
T16115 34376-34380 WDT denotes that
T16114 34365-34375 NN denotes mesenchyme
T16113 34355-34364 VBN denotes thickened
T16112 34352-34354 IN denotes of
T16111 34347-34351 NN denotes zone
T16110 34343-34346 DT denotes the
T16109 34340-34342 IN denotes of
T16108 34330-34339 NN denotes expansion
T16107 34327-34329 DT denotes an
T16106 34315-34319 RB denotes also
T16105 34320-34326 VBD denotes showed
T16104 34305-34306 CD denotes 2
T16103 34304-34305 HYPH denotes /
T16102 34299-34304 NN denotes Pygo1
T16101 34307-34314 NNS denotes mutants
T16100 34295-34298 DT denotes The
T16099 34294-34403 sentence denotes The Pygo1/2 mutants also showed an expansion of the zone of thickened mesenchyme that caps the ureteric bud.
T16098 34293-34294 . denotes .
T16097 34281-34289 JJ denotes ureteric
T16096 34290-34293 NN denotes bud
T16095 34277-34280 DT denotes the
T16094 34274-34276 IN denotes in
T16093 34260-34263 NN denotes Wnt
T16092 34264-34273 NN denotes signaling
T16091 34250-34259 VBN denotes disrupted
T16090 34238-34240 PRP denotes we
T16089 34236-34238 , denotes ,
T16088 34222-34223 HYPH denotes /
T16087 34223-34228 NN denotes Pygo2
T16086 34217-34222 NN denotes Pygo1
T16085 34229-34236 NNS denotes mutants
T16084 34213-34216 DT denotes the
T16083 34210-34212 IN denotes in
T16082 34241-34249 VBD denotes observed
T16081 34202-34209 IN denotes whereas
T16080 34200-34202 , denotes ,
T16079 34197-34200 NN denotes bud
T16078 34193-34196 DT denotes the
T16077 34190-34192 IN denotes to
T16076 34179-34189 NN denotes mesenchyme
T16075 34175-34178 DT denotes the
T16074 34170-34174 IN denotes from
T16073 34160-34169 NN denotes signaling
T16072 34155-34159 NN denotes GDNF
T16071 34151-34154 CC denotes and
T16070 34140-34150 NN denotes mesenchyme
T16069 34136-34139 DT denotes the
T16068 34133-34135 IN denotes to
T16067 34120-34128 JJ denotes ureteric
T16066 34129-34132 NN denotes bud
T16065 34116-34119 DT denotes the
T16064 34111-34115 IN denotes from
T16063 34101-34110 NN denotes signaling
T16062 34097-34100 NN denotes Wnt
T16061 34089-34096 IN denotes between
T16060 34075-34083 NN denotes feedback
T16059 34067-34074 VBN denotes altered
T16058 34084-34088 NN denotes loop
T16057 34064-34066 DT denotes an
T16056 34043-34048 NN denotes Wnt11
T16055 34049-34056 NNS denotes mutants
T16054 34039-34042 DT denotes the
T16053 34037-34039 , denotes ,
T16052 34057-34063 VBD denotes showed
T16051 34030-34037 RB denotes Further
T16050 34029-34294 sentence denotes Further, the Wnt11 mutants showed an altered feedback loop between Wnt signaling from the ureteric bud to the mesenchyme and GDNF signaling from the mesenchyme to the bud, whereas in the Pygo1/Pygo2 mutants, we observed disrupted Wnt signaling in the ureteric bud.
T16049 34028-34029 . denotes .
T16048 34015-34018 NN denotes Wnt
T16047 34019-34028 NN denotes signaling
T16046 34005-34014 JJ denotes canonical
T16045 33983-33990 NN denotes Pygopus
T16044 33991-33996 NNS denotes genes
T16043 33979-33982 DT denotes the
T16042 33997-34004 VBP denotes promote
T16041 33971-33978 IN denotes whereas
T16040 33969-33971 , denotes ,
T16039 33968-33969 -RRB- denotes )
T15864 32972-32975 PRP$ denotes its
T15862 32955-32963 JJ denotes ureteric
T15861 32964-32967 NN denotes bud
T15860 32951-32954 DT denotes the
T15859 32948-32950 IN denotes in
T15858 32934-32937 NN denotes Wnt
T15857 32938-32947 NN denotes signaling
T15856 32924-32933 JJ denotes canonical
T15855 32921-32923 IN denotes of
T15854 32912-32920 NN denotes presence
T15853 32908-32911 DT denotes the
T15852 32898-32907 VBD denotes indicated
T15851 32879-32888 NN denotes transgene
T15850 32874-32875 HYPH denotes -
T15849 32875-32878 NN denotes gal
T15848 32871-32874 NN denotes BAT
T15847 32889-32897 NN denotes reporter
T15846 32867-32870 DT denotes The
T15845 32866-33013 sentence denotes The BAT-gal transgene reporter indicated the presence of canonical Wnt signaling in the ureteric bud and its derivatives in the developing kidney.
T15844 32865-32866 . denotes .
T15843 32854-32865 NN denotes development
T15842 32847-32853 NN denotes kidney
T15841 32844-32846 IN denotes in
T15840 32831-32834 NN denotes Wnt
T15839 32825-32830 JJ denotes novel
T15838 32835-32843 NN denotes function
T15837 32823-32824 DT denotes a
T15836 32811-32813 PRP denotes we
T15835 32804-32810 NN denotes report
T15834 32799-32803 DT denotes this
T15833 32814-32822 VBP denotes describe
T15832 32796-32798 IN denotes In
T15831 32795-32866 sentence denotes In this report we describe a novel Wnt function in kidney development.
T15830 32794-32795 . denotes .
T15829 32793-32794 -RRB- denotes ]
T15828 32792-32793 CD denotes 4
T15827 32791-32792 -LRB- denotes [
T16341 35674-35684 JJ denotes responsive
T16340 35670-35673 NN denotes Wnt
T16339 35685-35693 NN denotes promoter
T16338 35666-35669 CD denotes one
T16337 35661-35665 RB denotes only
T16336 35658-35660 IN denotes of
T16335 35641-35651 NN denotes expression
T16334 35652-35657 NN denotes level
T16333 35637-35640 DT denotes the
T16332 35710-35716 VBZ denotes allows
T16331 35609-35618 NN denotes transgene
T16330 35604-35605 HYPH denotes -
T16329 35605-35608 NN denotes gal
T16328 35601-35604 NN denotes BAT
T16327 35619-35627 NN denotes reporter
T16326 35597-35600 DT denotes the
T16325 35628-35636 VBZ denotes monitors
T16324 35589-35596 IN denotes Whereas
T16323 35588-35779 sentence denotes Whereas the BAT-gal transgene reporter monitors the expression level of only one Wnt responsive promoter, the microarray allows the analysis of the activity levels of promoters of all genes.
T16322 35587-35588 . denotes .
T16321 35577-35587 NN denotes conclusion
T16320 35572-35576 DT denotes this
T16319 35556-35563 RB denotes further
T16318 35564-35571 VBZ denotes support
T16317 35537-35547 NN denotes microarray
T16316 35548-35555 NNS denotes results
T16315 35533-35536 DT denotes The
T16314 35532-35588 sentence denotes The microarray results further support this conclusion.
T16313 35531-35532 . denotes .
T16312 35521-35531 NNS denotes components
T16311 35511-35520 JJ denotes essential
T16310 35507-35510 RB denotes not
T16309 35503-35506 CC denotes and
T16308 35501-35503 , denotes ,
T16307 35492-35501 NN denotes intensity
T16306 35478-35481 NN denotes Wnt
T16305 35482-35491 NN denotes signaling
T16304 35468-35477 JJ denotes canonical
T16303 35465-35467 IN denotes of
T16302 35454-35464 NNS denotes modulators
T16301 35449-35453 JJ denotes mere
T16300 35443-35448 RB denotes often
T16299 35425-35432 NN denotes Pygopus
T16298 35433-35438 NNS denotes genes
T16297 35415-35424 JJ denotes mammalian
T16296 35412-35414 IN denotes by
T16295 35404-35411 VBN denotes encoded
T16294 35395-35403 NN denotes proteins
T16293 35391-35394 DT denotes the
T16292 35439-35442 VBP denotes are
T16291 35386-35390 IN denotes that
T16290 35378-35385 VBP denotes suggest
T16289 35370-35377 NNS denotes results
T16288 35364-35369 DT denotes These
T16287 35363-35532 sentence denotes These results suggest that the proteins encoded by mammalian Pygopus genes are often mere modulators of canonical Wnt signaling intensity, and not essential components.
T16286 35362-35363 . denotes .
T16285 35352-35362 NNS denotes exceptions
T16284 35348-35351 JJ denotes few
T16283 35343-35347 IN denotes with
T16282 35341-35343 , denotes ,
T16281 35330-35341 NN denotes abnormality
T16280 35319-35329 JJ denotes detectable
T16279 35311-35318 IN denotes without
T16278 35291-35300 RB denotes generally
T16277 35277-35290 NN denotes organogenesis
T16276 35275-35277 , denotes ,
T16275 35301-35310 VBD denotes proceeded
T16274 35269-35275 RB denotes Indeed
T16273 35268-35363 sentence denotes Indeed, organogenesis generally proceeded without detectable abnormality, with few exceptions.
T16272 35267-35268 . denotes .
T16271 35260-35267 NNS denotes mutants
T16270 35253-35254 HYPH denotes /
T16269 35254-35259 NN denotes Pygo2
T16268 35248-35253 NN denotes Pygo1
T16267 35245-35247 IN denotes in
T16266 35233-35244 NN denotes development
T16265 35226-35232 JJ denotes normal
T16264 35213-35225 RB denotes surprisingly
T16263 35205-35212 VBG denotes showing
T16262 35202-35204 IN denotes in
T16261 35195-35201 JJ denotes unique
T16260 35191-35194 RB denotes not
T16259 35178-35185 NNS denotes kidneys
T16258 35174-35177 DT denotes the
T16257 35172-35174 , denotes ,
T16256 35164-35172 NN denotes addition
T16255 35186-35190 VBD denotes were
T15826 32768-32779 JJ denotes metanephric
T15825 32780-32790 NN denotes mesenchyme
T15824 32764-32767 DT denotes the
T15823 32761-32763 IN denotes in
T15822 32750-32760 NN denotes expression
T15821 32745-32749 NN denotes GDNF
T15820 32737-32744 VBZ denotes induces
T15819 32733-32736 CC denotes and
T15818 32724-32727 NN denotes bud
T15817 32715-32723 JJ denotes ureteric
T15816 32728-32732 NNS denotes tips
T15815 32711-32714 DT denotes the
T15814 32708-32710 IN denotes by
T15813 32696-32698 VBZ denotes is
T15812 32690-32695 NN denotes Wnt11
T15811 32688-32690 , denotes ,
T15810 32680-32688 NN denotes addition
T15809 32699-32707 VBN denotes produced
T15808 32677-32679 IN denotes In
T15807 32676-32795 sentence denotes In addition, Wnt11 is produced by the ureteric bud tips and induces GDNF expression in the metanephric mesenchyme [4].
T15806 32675-32676 . denotes .
T15805 32674-32675 -RRB- denotes ]
T15804 32673-32674 CD denotes 3
T15803 32672-32673 -LRB- denotes [
T15802 32658-32671 NN denotes nephrogenesis
T15801 32654-32657 IN denotes for
T15800 32640-32644 RB denotes also
T15799 32645-32653 VBN denotes required
T15798 32637-32639 VBZ denotes is
T15797 32633-32636 CC denotes and
T15796 32631-32633 , denotes ,
T15795 32609-32620 JJ denotes metanephric
T15794 32621-32631 NN denotes mesenchyme
T15793 32605-32608 DT denotes the
T15792 32602-32604 IN denotes by
T15791 32594-32596 VBZ denotes is
T15790 32597-32601 VBN denotes made
T15789 32588-32593 WDT denotes which
T15788 32586-32588 , denotes ,
T15787 32585-32586 -RRB- denotes ]
T15786 32584-32585 CD denotes 2
T15785 32583-32584 -LRB- denotes [
T15784 32578-32582 NN denotes Wnt4
T15783 32569-32574 NN denotes Wnt9b
T15782 32566-32568 IN denotes of
T15781 32575-32577 VBZ denotes is
T15780 32555-32565 RB denotes Downstream
T15779 32554-32676 sentence denotes Downstream of Wnt9b is Wnt4 [2], which is made by the metanephric mesenchyme, and is also required for nephrogenesis [3].
T15778 32553-32554 . denotes .
T15777 32552-32553 -RRB- denotes ]
T15776 32551-32552 CD denotes 2
T15775 32550-32551 -LRB- denotes [
T15774 32536-32549 NN denotes nephrogenesis
T15773 32528-32535 VB denotes undergo
T15772 32525-32527 TO denotes to
T15771 32502-32513 JJ denotes metanephric
T15770 32514-32524 NN denotes mesenchyme
T15769 32498-32501 DT denotes the
T15768 32490-32497 VBZ denotes induces
T15767 32486-32489 CC denotes and
T15766 32473-32481 JJ denotes ureteric
T15765 32482-32485 NN denotes bud
T15764 32469-32472 DT denotes the
T15763 32466-32468 IN denotes by
T15762 32458-32460 VBZ denotes is
T15761 32461-32465 VBN denotes made
T15760 32452-32457 NN denotes Wnt9b
T15759 32451-32554 sentence denotes Wnt9b is made by the ureteric bud and induces the metanephric mesenchyme to undergo nephrogenesis [2].
T15758 32450-32451 . denotes .
T15757 32437-32450 NN denotes nephrogenesis
T15756 32434-32436 IN denotes of
T15755 32427-32433 NNS denotes stages
T15754 32419-32426 JJ denotes several
T15753 32416-32418 IN denotes in
T15752 32405-32415 NN denotes importance
T15751 32396-32404 JJ denotes critical
T15750 32393-32395 IN denotes of
T15749 32390-32392 VB denotes be
T15748 32387-32389 TO denotes to
T15747 32376-32380 VBN denotes been
T15746 32372-32375 VBZ denotes has
T15745 32362-32371 NN denotes signaling
T15744 32358-32361 NN denotes Wnt
T15743 32352-32357 WDT denotes which
T15742 32381-32386 VBN denotes shown
T15741 32349-32351 IN denotes in
T15740 32347-32349 , denotes ,
T15739 32330-32340 VBG denotes developing
T15738 32341-32347 NN denotes kidney
T15737 32326-32329 DT denotes the
T15736 32323-32325 IN denotes on
T15735 32314-32322 NN denotes analysis
T15734 32310-32313 PRP$ denotes our
T15733 32302-32309 VBD denotes focused
T15732 32299-32301 PRP denotes We
T15731 32298-32451 sentence denotes We focused our analysis on the developing kidney, in which Wnt signaling has been shown to be of critical importance in several stages of nephrogenesis.
T15730 32297-32298 . denotes .
T15729 32281-32289 VBN denotes targeted
T15728 32290-32297 NNS denotes alleles
T15727 32277-32280 DT denotes the
T15726 32274-32276 IN denotes of
T15725 32265-32273 NN denotes function
T15724 32256-32264 JJ denotes residual
T15723 32253-32255 IN denotes of
T15722 32246-32252 NN denotes result
T15721 32242-32245 DT denotes the
T15720 32228-32236 VBN denotes observed
T15719 32212-32216 JJ denotes mild
T15718 32201-32211 RB denotes relatively
T15717 32217-32227 NNS denotes phenotypes
T15716 32197-32200 DT denotes the
T15715 32237-32241 VBD denotes were
T15714 32192-32196 IN denotes that
T15713 32183-32191 JJ denotes unlikely
T15712 32178-32182 RB denotes very
T15711 32168-32177 RB denotes therefore
T15710 32165-32167 VBZ denotes is
T15709 32162-32164 PRP denotes It
T15708 32161-32298 sentence denotes It is therefore very unlikely that the relatively mild phenotypes observed were the result of residual function of the targeted alleles.
T15707 32160-32161 . denotes .
T15706 32149-32154 NN denotes amino
T15705 32155-32160 NNS denotes acids
T15704 32142-32144 IN denotes of
T15703 32145-32148 CD denotes 405
T15702 32138-32141 CD denotes 354
T15701 32134-32137 IN denotes for
T15700 32127-32133 VBG denotes coding
T15699 32116-32118 PRP denotes we
T15698 32114-32116 , denotes ,
T15697 32104-32109 NN denotes Pygo2
T15696 32110-32114 NN denotes gene
T15695 32100-32103 DT denotes the
T15694 32119-32126 VBD denotes deleted
T15693 32096-32099 IN denotes for
T15692 32092-32095 CC denotes and
T15691 32090-32092 , denotes ,
T15690 32079-32082 VBD denotes was
T15689 32067-32072 NN denotes amino
T15688 32061-32066 JJ denotes total
T15687 32073-32078 NNS denotes acids
T15686 32054-32056 IN denotes of
T15685 32057-32060 CD denotes 417
T15684 32050-32053 CD denotes 372
T15683 32046-32049 IN denotes for
T15682 32032-32038 NN denotes coding
T15681 32039-32045 NN denotes region
T15680 32028-32031 DT denotes the
T15679 32026-32028 , denotes ,
T15678 32016-32021 NN denotes Pygo1
T15677 32022-32026 NN denotes gene
T15676 32012-32015 DT denotes the
T15675 32083-32090 VBN denotes deleted
T15674 32008-32011 IN denotes For
T15673 32007-32161 sentence denotes For the Pygo1 gene, the coding region for 372 of 417 total amino acids was deleted, and for the Pygo2 gene, we deleted coding for 354 of 405 amino acids.
T15672 32006-32007 . denotes .
T15671 31990-31996 NN denotes coding
T15670 31984-31989 JJ denotes other
T15669 31997-32006 NNS denotes sequences
T15668 31979-31983 JJS denotes most
T15667 31971-31975 RB denotes well
T15666 31976-31978 IN denotes as
T15665 31968-31970 RB denotes as
T15664 31966-31968 , denotes ,
T15663 31955-31958 NN denotes PHD
T15662 31948-31954 JJ denotes entire
T15661 31959-31966 NNS denotes domains
T15660 31944-31947 DT denotes the
T15659 31941-31943 IN denotes of
T15658 31931-31940 NNS denotes deletions
T15657 31916-31922 NN denotes report
T15656 31911-31915 DT denotes this
T15655 31908-31910 IN denotes in
T15654 31903-31907 VBN denotes made
T15653 31923-31930 VBD denotes carried
T15652 31888-31894 NN denotes mutant
T15651 31881-31882 HYPH denotes /
T15650 31882-31887 NN denotes Pygo2
T15649 31876-31881 NN denotes Pygo1
T15483 30978-30982 RBR denotes more
T15482 30969-30972 VBD denotes did
T15481 30956-30959 NN denotes Wnt
T15480 30951-30952 HYPH denotes -
T15479 30952-30955 NN denotes gal
T15478 30948-30951 NN denotes BAT
T15477 30960-30968 NN denotes reporter
T15476 30944-30947 DT denotes the
T15475 30936-30943 NNS denotes tissues
T15474 30928-30935 JJ denotes several
T15473 30925-30927 IN denotes in
T15472 30973-30977 VB denotes show
T15471 30916-30924 IN denotes although
T15470 30914-30916 , denotes ,
T15469 30901-30902 HYPH denotes /
T15468 30902-30907 NN denotes Pygo2
T15467 30896-30901 NN denotes Pygo1
T15466 30889-30895 JJ denotes double
T15465 30908-30914 NN denotes mutant
T15464 30885-30888 DT denotes the
T15463 30882-30884 IN denotes of
T15462 30872-30881 NN denotes phenotype
T15461 30868-30871 DT denotes the
T15460 30865-30867 IN denotes in
T15459 30846-30854 VBN denotes detected
T15458 30855-30864 NN denotes synergism
T15457 30843-30845 DT denotes no
T15456 30833-30838 EX denotes there
T15455 30831-30833 , denotes ,
T15454 30839-30842 VBD denotes was
T15453 30820-30831 RB denotes Furthermore
T15452 30819-31016 sentence denotes Furthermore, there was no detected synergism in the phenotype of the double Pygo1/Pygo2 mutant, although in several tissues the BAT-gal Wnt reporter did show more a severe reduction in expression.
T15451 30818-30819 . denotes .
T15450 30811-30818 JJ denotes fertile
T15449 30807-30810 CC denotes and
T15448 30800-30806 JJ denotes normal
T15447 30787-30794 NNS denotes mutants
T15446 30776-30786 JJ denotes homozygous
T16038 33967-33968 -RRB- denotes ]
T16037 33965-33967 CD denotes 31
T16036 33964-33965 -LRB- denotes [
T16035 33953-33957 VBN denotes been
T16034 33948-33952 VBP denotes have
T16033 33937-33947 NNS denotes exceptions
T16032 33958-33963 VBN denotes noted
T16031 33928-33936 IN denotes although
T16030 33927-33928 -LRB- denotes (
T16029 33925-33927 , denotes ,
T16028 33905-33917 JJ denotes noncanonical
T16027 33918-33925 NN denotes pathway
T16026 33903-33904 DT denotes a
T16025 33895-33902 IN denotes through
T16024 33891-33894 VB denotes act
T16023 33888-33890 TO denotes to
T16022 33870-33879 RB denotes generally
T16021 33867-33869 VBZ denotes is
T16020 33880-33887 VBN denotes thought
T16019 33861-33866 NN denotes Wnt11
T16018 33860-34029 sentence denotes Wnt11 is generally thought to act through a noncanonical pathway, (although exceptions have been noted [31]), whereas the Pygopus genes promote canonical Wnt signaling.
T16017 33859-33860 . denotes .
T16016 33851-33859 JJ denotes distinct
T16015 33848-33850 VB denotes be
T16014 33845-33847 TO denotes to
T16013 33838-33844 JJ denotes likely
T16012 33832-33834 , denotes ,
T16011 33825-33832 RB denotes however
T16010 33823-33825 , denotes ,
T16009 33834-33837 VBP denotes are
T16008 33802-33812 VBG denotes underlying
T16007 33813-33823 NNS denotes mechanisms
T16006 33798-33801 DT denotes The
T16005 33797-33860 sentence denotes The underlying mechanisms, however, are likely to be distinct.
T16004 33796-33797 . denotes .
T16003 33795-33796 -RRB- denotes ]
T16002 33794-33795 CD denotes 4
T16001 33793-33794 -LRB- denotes [
T16000 33785-33792 NNS denotes mutants
T15999 33779-33784 NN denotes Wnt11
T15998 33775-33778 IN denotes for
T15997 33766-33774 VBN denotes reported
T15996 33755-33765 RB denotes previously
T15995 33750-33754 DT denotes that
T15994 33747-33749 IN denotes to
T15993 33739-33746 JJ denotes similar
T15992 33726-33738 RB denotes surprisingly
T15991 33710-33718 JJ denotes ureteric
T15990 33719-33722 NN denotes bud
T15989 33706-33709 DT denotes the
T15988 33703-33705 IN denotes of
T15987 33679-33688 NN denotes branching
T15986 33689-33702 NN denotes morphogenesis
T15985 33671-33678 VBN denotes reduced
T15984 33668-33670 IN denotes of
T15983 33723-33725 VBZ denotes is
T15982 33651-33657 NN denotes mutant
T15981 33644-33645 HYPH denotes /
T15980 33645-33650 NN denotes Pygo2
T15979 33639-33644 NN denotes Pygo1
T15978 33658-33667 NN denotes phenotype
T15977 33635-33638 DT denotes The
T15976 33634-33797 sentence denotes The Pygo1/Pygo2 mutant phenotype of reduced branching morphogenesis of the ureteric bud is surprisingly similar to that previously reported for Wnt11 mutants [4].
T15975 33633-33634 . denotes .
T15974 33624-33633 NN denotes signaling
T15973 33620-33623 NN denotes bud
T15972 33611-33619 JJ denotes ureteric
T15971 33608-33610 IN denotes to
T15970 33597-33607 NN denotes mesenchyme
T15969 33582-33586 RB denotes then
T15968 33559-33570 JJ denotes metanephric
T15967 33571-33581 NN denotes mesenchyme
T15966 33555-33558 DT denotes the
T15965 33552-33554 IN denotes to
T15964 33587-33596 VBG denotes affecting
T15963 33538-33541 NN denotes Wnt
T15962 33542-33551 NN denotes signaling
T15961 33530-33537 VBN denotes altered
T15960 33525-33529 IN denotes with
T15959 33523-33525 , denotes ,
T15958 33516-33523 NNS denotes effects
T15957 33507-33515 JJ denotes indirect
T15956 33504-33506 IN denotes of
T15955 33497-33503 NN denotes result
T15954 33493-33496 DT denotes the
T15953 33466-33474 VBN denotes observed
T15952 33475-33488 NNS denotes abnormalities
T15951 33462-33465 DT denotes the
T15950 33489-33492 VBP denotes are
T15949 33457-33461 IN denotes that
T15948 33448-33456 JJ denotes possible
T15947 33437-33439 PRP denotes it
T15946 33435-33437 , denotes ,
T15945 33423-33431 JJ denotes ureteric
T15944 33432-33435 NN denotes bud
T15943 33419-33422 DT denotes the
T15942 33416-33418 IN denotes to
T15941 33402-33405 NN denotes Wnt
T15940 33406-33415 NN denotes signaling
T15939 33395-33401 JJ denotes direct
T15938 33440-33447 VBZ denotes remains
T15937 33368-33376 JJS denotes simplest
T15936 33377-33391 NN denotes interpretation
T15935 33364-33367 DT denotes the
T15934 33392-33394 VBZ denotes is
T15933 33358-33363 IN denotes While
T15932 33357-33634 sentence denotes While the simplest interpretation is direct Wnt signaling to the ureteric bud, it remains possible that the observed abnormalities are the result of indirect effects, with altered Wnt signaling to the metanephric mesenchyme then affecting mesenchyme to ureteric bud signaling.
T15931 33356-33357 . denotes .
T15930 33344-33352 JJ denotes ureteric
T15929 33353-33356 NN denotes bud
T15928 33340-33343 DT denotes the
T15927 33337-33339 IN denotes of
T15926 33323-33336 NN denotes morphogenesis
T15925 33313-33322 VBG denotes branching
T15924 33310-33312 IN denotes in
T15923 33296-33299 NN denotes Wnt
T15922 33300-33309 NN denotes signaling
T15921 33286-33295 JJ denotes canonical
T15920 33282-33285 IN denotes for
T15919 33277-33281 NN denotes role
T15918 33275-33276 DT denotes a
T15917 33264-33274 VBG denotes indicating
T15916 33262-33264 , denotes ,
T15915 33255-33262 NNS denotes mutants
T15914 33252-33254 IN denotes in
T15913 33238-33246 JJ denotes ureteric
T15912 33247-33251 NN denotes tree
T15911 33234-33237 DT denotes the
T15910 33231-33233 IN denotes of
T15909 33220-33230 NN denotes morphology
T15908 33212-33219 VBN denotes altered
T15907 33208-33211 CC denotes and
T15906 33196-33202 NN denotes kidney
T15905 33203-33207 NN denotes size
T15904 33188-33195 VBN denotes reduced
T15903 33186-33188 , denotes ,
T15902 33179-33186 NN denotes density
T15901 33175-33178 NN denotes tip
T15900 33166-33174 JJ denotes ureteric
T15899 33163-33165 IN denotes in
T15898 33144-33153 VBG denotes resulting
T15897 33154-33162 NN denotes decrease
T15896 33142-33143 DT denotes a
T15895 33130-33132 PRP denotes we
T15894 33128-33130 , denotes ,
T15893 33120-33128 NN denotes addition
T15892 33133-33141 VBD denotes observed
T15891 33117-33119 IN denotes In
T15890 33116-33357 sentence denotes In addition, we observed a resulting decrease in ureteric tip density, reduced kidney size and altered morphology of the ureteric tree in mutants, indicating a role for canonical Wnt signaling in branching morphogenesis of the ureteric bud.
T15889 33115-33116 . denotes .
T15888 33106-33115 NN denotes signaling
T15887 33102-33105 NN denotes Wnt
T15886 33099-33101 IN denotes of
T15885 33089-33098 NN denotes reduction
T15884 33077-33088 JJ denotes significant
T15883 33066-33076 VBG denotes suggesting
T15882 33064-33066 , denotes ,
T15881 33056-33059 VBD denotes was
T15880 33049-33055 NN denotes signal
T15879 33044-33048 DT denotes this
T15878 33030-33035 NN denotes Pygo2
T15877 33036-33043 NNS denotes mutants
T15876 33026-33029 DT denotes the
T15875 33023-33025 IN denotes in
T15874 33021-33023 , denotes ,
T15873 33060-33064 VBN denotes lost
T15872 33014-33021 RB denotes Further
T15871 33013-33116 sentence denotes Further, in the Pygo2 mutants this signal was lost, suggesting significant reduction of Wnt signaling.
T15870 33012-33013 . denotes .
T15869 32995-33005 VBG denotes developing
T15868 33006-33012 NN denotes kidney
T15867 32991-32994 DT denotes the
T15866 32988-32990 IN denotes in
T15865 32976-32987 NNS denotes derivatives
T15445 30770-30775 NN denotes Pygo1
T15444 30795-30799 VBD denotes were
T15443 30764-30769 IN denotes while
T15442 30762-30764 , denotes ,
T15441 30749-30762 NNS denotes abnormalities
T15440 30741-30748 JJ denotes limited
T15439 30734-30740 VBD denotes showed
T15438 30730-30733 CC denotes and
T15437 30724-30729 NN denotes birth
T15436 30721-30723 IN denotes to
T15435 30711-30720 VBD denotes developed
T15434 30703-30710 NNS denotes mutants
T15433 30697-30702 NN denotes Pygo2
T15432 30696-30819 sentence denotes Pygo2 mutants developed to birth and showed limited abnormalities, while Pygo1 homozygous mutants were normal and fertile.
T15431 30695-30696 . denotes .
T15430 30687-30695 JJ denotes striking
T15429 30665-30666 HYPH denotes /
T15428 30660-30665 NN denotes Pygo1
T15427 30666-30671 NN denotes Pygo2
T15426 30653-30659 JJ denotes double
T15425 30650-30652 CC denotes or
T15424 30648-30650 , denotes ,
T15423 30643-30648 NN denotes Pygo2
T15422 30641-30643 , denotes ,
T15421 30672-30681 NNS denotes mutations
T15420 30636-30641 NN denotes Pygo1
T15419 30627-30635 VBN denotes targeted
T15418 30622-30626 IN denotes with
T15417 30617-30621 NNS denotes mice
T15416 30614-30616 IN denotes of
T15415 30598-30602 JJ denotes mild
T15414 30587-30597 RB denotes relatively
T15413 30603-30613 NNS denotes phenotypes
T15412 30583-30586 DT denotes the
T15411 30581-30583 , denotes ,
T15410 30571-30581 NNP denotes Drosophila
T15409 30568-30570 IN denotes in
T15408 30560-30567 NNS denotes results
T15407 30554-30559 DT denotes these
T15406 30682-30686 VBD denotes were
T15405 30548-30553 VBN denotes Given
T15404 30547-30696 sentence denotes Given these results in Drosophila, the relatively mild phenotypes of mice with targeted Pygo1, Pygo2, or double Pygo1/Pygo2 mutations were striking.
T15403 30546-30547 . denotes .
T15402 30545-30546 -RRB- denotes ]
T15401 30544-30545 CD denotes 8
T15400 30543-30544 -LRB- denotes [
T15399 30541-30542 . denotes .
T15398 30540-30541 '' denotes "
T15397 30520-30532 NN denotes transduction
T15396 30513-30519 NN denotes signal
T15395 30510-30512 NN denotes Wg
T15394 30533-30540 NN denotes pathway
T15393 30506-30509 DT denotes the
T15392 30503-30505 IN denotes in
T15391 30483-30492 JJ denotes essential
T15390 30493-30502 NN denotes component
T15389 30480-30482 DT denotes an
T15388 30472-30476 NN denotes Pygo
T15387 30471-30472 `` denotes "
T15386 30477-30479 VBZ denotes is
T15385 30466-30470 IN denotes that
T15384 30456-30465 VBD denotes concluded
T15383 30452-30455 CC denotes and
T15382 30450-30452 , denotes ,
T15381 30439-30450 NN denotes development
T15380 30431-30438 JJ denotes cardiac
T15379 30427-30430 CC denotes and
T15378 30425-30427 , denotes ,
T15377 30411-30418 JJ denotes nervous
T15376 30419-30425 NN denotes system
T15375 30403-30410 JJ denotes central
T15374 30401-30403 , denotes ,
T15373 30389-30401 NN denotes constriction
T15372 30382-30388 NN denotes midgut
T15371 30380-30382 , denotes ,
T15370 30370-30380 NN denotes patterning
T15369 30362-30369 NN denotes cuticle
T15368 30359-30361 IN denotes on
T15367 30350-30358 NN denotes mutation
T15366 30345-30349 NN denotes Pygo
T15365 30342-30344 IN denotes of
T15364 30334-30341 NNS denotes effects
T15363 30330-30333 DT denotes the
T15362 30310-30320 NNP denotes Drosophila
T15361 30307-30309 IN denotes in
T15360 30321-30329 VBD denotes examined
T15359 30294-30300 JJ denotes second
T15358 30301-30306 NN denotes study
T15357 30292-30293 DT denotes A
T15356 30291-30547 sentence denotes A second study in Drosophila examined the effects of Pygo mutation on cuticle patterning, midgut constriction, central nervous system, and cardiac development, and concluded that "Pygo is an essential component in the Wg signal transduction pathway". [8].
T15355 30290-30291 . denotes .
T15354 30289-30290 -RRB- denotes ]
T15353 30287-30289 CD denotes 10
T15352 30286-30287 -LRB- denotes [
T15351 30271-30279 JJ denotes complete
T15350 30269-30270 DT denotes a
T15349 30263-30268 NNS denotes cases
T15348 30260-30262 CD denotes 10
T15347 30280-30285 NN denotes block
T15346 30257-30259 IN denotes in
T15345 30253-30256 CC denotes and
T15344 30243-30252 NN denotes signaling
T15343 30239-30242 NN denotes Wnt
T15342 30236-30238 IN denotes of
T15341 30214-30225 JJ denotes significant
T15340 30226-30235 NN denotes reduction
T15339 30212-30213 DT denotes a
T15338 30202-30207 EX denotes there
T15337 30196-30201 NNS denotes cases
T15336 30194-30195 CD denotes 2
T15335 30208-30211 VBD denotes was
T15334 30191-30193 IN denotes In
T15333 30190-30291 sentence denotes In 2 cases there was a significant reduction of Wnt signaling and in 10 cases a complete block [10].
T15332 30189-30190 . denotes .
T15331 30184-30189 NNS denotes discs
T15330 30171-30174 NN denotes eye
T15329 30167-30170 CC denotes and
T15328 30165-30167 , denotes ,
T15327 30161-30165 NN denotes wing
T15326 30159-30161 , denotes ,
T15325 30175-30183 JJ denotes imaginal
T15324 30156-30159 NN denotes leg
T15323 30153-30155 IN denotes of
T15322 30144-30152 NN denotes analysis
T15321 30134-30143 VBG denotes including
T15320 30132-30134 , denotes ,
T15319 30118-30122 VBD denotes were
T15318 30110-30117 NNS denotes mutants
T15317 30105-30109 NN denotes Pygo
T15316 30102-30104 IN denotes in
T15315 30092-30101 NN denotes signaling
T15314 30088-30091 NN denotes Wnt
T15313 30085-30087 IN denotes of
T15312 30067-30075 JJ denotes distinct
T15311 30076-30084 NNS denotes measures
T15310 30064-30066 CD denotes 12
T15309 30062-30064 , denotes ,
T15308 30057-30062 NN denotes study
T15307 30053-30056 CD denotes one
T15306 30123-30132 VBN denotes performed
T15305 30050-30052 IN denotes In
T15304 30049-30190 sentence denotes In one study, 12 distinct measures of Wnt signaling in Pygo mutants were performed, including analysis of leg, wing, and eye imaginal discs.
T15303 30048-30049 . denotes .
T15302 30035-30038 NN denotes Wnt
T15301 30039-30048 NN denotes signaling
T15300 30025-30034 JJ denotes canonical
T15299 30022-30024 IN denotes of
T15298 30009-30012 JJ denotes key
T15297 30013-30021 NN denotes mediator
T15296 30007-30008 DT denotes a
T15295 29991-29998 NN denotes Pygopus
T15294 29999-30003 NN denotes gene
T15293 29987-29990 DT denotes the
T15292 29985-29987 , denotes ,
T15291 29975-29985 NNP denotes Drosophila
T15290 30004-30006 VBZ denotes is
T15289 29972-29974 IN denotes In
T15648 31895-31902 NNS denotes alleles
T15647 31872-31875 DT denotes The
T15646 31871-32007 sentence denotes The Pygo1/Pygo2 mutant alleles made in this report carried deletions of the entire PHD domains, as well as most other coding sequences.
T15645 31870-31871 . denotes .
T15644 31869-31870 -RRB- denotes ]
T15643 31868-31869 CD denotes 8
T15642 31867-31868 -LRB- denotes [
T15641 31855-31866 NN denotes development
T15640 31850-31854 NN denotes disc
T15639 31841-31849 JJ denotes imaginal
T15638 31837-31840 CC denotes and
T15637 31823-31836 NN denotes embryogenesis
T15636 31818-31822 CC denotes both
T15635 31815-31817 IN denotes in
T15634 31806-31814 NN denotes function
T15633 31796-31805 NN denotes signaling
T15632 31792-31795 NN denotes Wnt
T15631 31784-31786 , denotes ,
T15630 31776-31784 NN denotes tyrosine
T15629 31773-31775 IN denotes to
T15628 31764-31772 NN denotes cysteine
T15627 31759-31763 IN denotes from
T15626 31748-31751 NN denotes PHD
T15625 31752-31758 NN denotes domain
T15624 31744-31747 DT denotes the
T15623 31741-31743 IN denotes in
T15622 31737-31740 CD denotes 802
T15621 31732-31736 NN denotes acid
T15620 31726-31731 NN denotes amino
T15619 31715-31725 VBG denotes converting
T15618 31697-31705 NN denotes missense
T15617 31690-31696 JJ denotes single
T15616 31706-31714 NN denotes mutation
T15615 31688-31689 DT denotes a
T15614 31683-31687 IN denotes with
T15613 31681-31683 , denotes ,
T15612 31666-31674 NN denotes pygoF107
T15611 31675-31681 NN denotes allele
T15610 31662-31665 DT denotes the
T15609 31651-31661 NNP denotes Drosophila
T15608 31786-31791 VBZ denotes loses
T15607 31648-31650 IN denotes In
T15606 31647-31871 sentence denotes In Drosophila the pygoF107 allele, with a single missense mutation converting amino acid 802 in the PHD domain from cysteine to tyrosine, loses Wnt signaling function in both embryogenesis and imaginal disc development [8].
T15605 31646-31647 . denotes .
T15604 31645-31646 -RRB- denotes ]
T15603 31644-31645 CD denotes 8
T15602 31643-31644 -LRB- denotes [
T15601 31630-31642 NNS denotes interactions
T15600 31621-31622 HYPH denotes -
T15599 31622-31629 NN denotes protein
T15598 31614-31621 NN denotes protein
T15597 31610-31613 CC denotes and
T15596 31599-31609 NN denotes remodeling
T15595 31589-31598 NN denotes chromatin
T15594 31586-31588 IN denotes in
T15593 31570-31574 VBN denotes been
T15592 31575-31585 VBN denotes implicated
T15591 31565-31569 VBP denotes have
T15590 31561-31564 CC denotes and
T15589 31559-31561 , denotes ,
T15588 31552-31559 NNS denotes factors
T15587 31538-31551 NN denotes transcription
T15586 31528-31537 VBG denotes including
T15585 31526-31528 , denotes ,
T15584 31518-31526 NN denotes proteins
T15583 31510-31517 JJ denotes diverse
T15582 31507-31509 IN denotes in
T15581 31497-31500 VBP denotes are
T15580 31501-31506 VBN denotes found
T15579 31489-31496 NNS denotes domains
T15578 31485-31488 NN denotes PHD
T15577 31484-31647 sentence denotes PHD domains are found in diverse proteins, including transcription factors, and have been implicated in chromatin remodeling and protein-protein interactions [8].
T15576 31483-31484 . denotes .
T15575 31474-31478 NN denotes zinc
T15574 31479-31483 NNS denotes ions
T15573 31470-31473 CD denotes two
T15572 31462-31469 VB denotes chelate
T15571 31459-31461 TO denotes to
T15570 31449-31458 VBN denotes predicted
T15569 31447-31449 , denotes ,
T15568 31438-31447 NN denotes histidine
T15567 31436-31437 DT denotes a
T15566 31432-31435 CC denotes and
T15565 31422-31431 NNS denotes cysteines
T15564 31416-31421 CD denotes seven
T15563 31411-31415 IN denotes with
T15562 31399-31404 NN denotes amino
T15561 31405-31410 NNS denotes acids
T15560 31396-31398 CD denotes 60
T15559 31393-31395 VBZ denotes is
T15558 31382-31385 NN denotes PHD
T15557 31386-31392 NN denotes domain
T15556 31378-31381 DT denotes The
T15555 31377-31484 sentence denotes The PHD domain is 60 amino acids with seven cysteines and a histidine, predicted to chelate two zinc ions.
T15554 31376-31377 . denotes .
T15553 31367-31376 NN denotes signaling
T15552 31364-31366 NN denotes Wg
T15551 31361-31363 IN denotes in
T15550 31352-31360 NN denotes function
T15549 31344-31351 NN denotes Pygopus
T15548 31340-31343 IN denotes for
T15547 31330-31339 JJ denotes necessary
T15546 31319-31329 RB denotes absolutely
T15545 31305-31308 NN denotes PHD
T15544 31309-31315 NN denotes domain
T15543 31301-31304 DT denotes the
T15542 31316-31318 VBZ denotes is
T15541 31296-31300 IN denotes that
T15540 31285-31289 VBN denotes been
T15539 31281-31284 VBZ denotes has
T15538 31278-31280 PRP denotes it
T15537 31276-31278 , denotes ,
T15536 31266-31276 NNP denotes Drosophila
T15535 31290-31295 VBN denotes shown
T15534 31263-31265 IN denotes In
T15533 31262-31377 sentence denotes In Drosophila, it has been shown that the PHD domain is absolutely necessary for Pygopus function in Wg signaling.
T15532 31261-31262 . denotes .
T15531 31256-31261 NNS denotes nulls
T15530 31245-31255 JJ denotes functional
T15529 31235-31244 RB denotes certainly
T15528 31228-31234 RB denotes almost
T15527 31222-31224 , denotes ,
T15526 31215-31222 RB denotes however
T15525 31213-31215 , denotes ,
T15524 31207-31213 NN denotes report
T15523 31202-31206 DT denotes this
T15522 31199-31201 IN denotes in
T15521 31189-31198 VBN denotes described
T15520 31224-31227 VBP denotes are
T15519 31172-31180 NN denotes deletion
T15518 31164-31171 NN denotes Pygopus
T15517 31181-31188 NNS denotes alleles
T15516 31160-31163 DT denotes The
T15515 31159-31262 sentence denotes The Pygopus deletion alleles described in this report, however, are almost certainly functional nulls.
T15514 31158-31159 . denotes .
T15513 31147-31152 NN denotes Pygo2
T15512 31143-31146 CC denotes and
T15511 31137-31142 NN denotes Pygo1
T15510 31153-31158 NNS denotes genes
T15509 31133-31136 DT denotes the
T15508 31130-31132 IN denotes of
T15507 31118-31129 NN denotes functioning
T15506 31108-31117 VB denotes eliminate
T15505 31105-31107 TO denotes to
T15504 31095-31104 VBG denotes targeting
T15503 31090-31094 NN denotes gene
T15502 31086-31089 DT denotes the
T15501 31083-31085 IN denotes of
T15500 31075-31082 NN denotes failure
T15499 31073-31074 DT denotes a
T15498 31051-31061 JJ denotes unexpected
T15497 31062-31069 NNS denotes results
T15496 31045-31050 DT denotes these
T15495 31042-31044 IN denotes of
T15494 31070-31072 VBZ denotes is
T15493 31021-31029 JJ denotes possible
T15492 31030-31041 NN denotes explanation
T15491 31017-31020 CD denotes One
T15490 31016-31159 sentence denotes One possible explanation of these unexpected results is a failure of the gene targeting to eliminate functioning of the Pygo1 and Pygo2 genes.
T15489 31015-31016 . denotes .
T15488 31005-31015 NN denotes expression
T15487 31002-31004 IN denotes in
T15486 30985-30991 JJ denotes severe
T15485 30992-31001 NN denotes reduction
T15484 30983-30984 DT denotes a
T12571 28291-28295 IN denotes with
T12570 28289-28291 , denotes ,
T12569 28268-28281 RB denotes significantly
T12568 28263-28267 VBD denotes were
T12567 28261-28262 -RRB- denotes ]
T12566 28259-28261 CD denotes 30
T12565 28258-28259 -LRB- denotes [
T12564 28252-28257 NN denotes Wisp1
T12563 28248-28251 CC denotes and
T12562 28246-28248 , denotes ,
T12561 28245-28246 -RRB- denotes ]
T12560 28243-28245 CD denotes 29
T12559 28242-28243 -LRB- denotes [
T12558 28232-28238 NN denotes cyclin
T12557 28239-28241 NN denotes D1
T12556 28223-28231 VBG denotes encoding
T12555 28217-28222 NN denotes Ccnd1
T12554 28214-28216 IN denotes of
T12553 28282-28289 VBN denotes changed
T12552 28199-28202 DT denotes the
T12551 28203-28213 NN denotes expression
T12550 28194-28198 RB denotes Only
T12549 28193-28362 sentence denotes Only the expression of Ccnd1 encoding cyclin D1 [29], and Wisp1 [30] were significantly changed, with expression level changes of <1.5-fold in Pygo1/Pygo2 null kidneys.
T12548 28192-28193 . denotes .
T12547 28191-28192 -RRB- denotes )
T12546 28190-28191 CD denotes 8
T12545 28183-28189 NN denotes Figure
T12544 28182-28183 -LRB- denotes (
T12543 28167-28173 NN denotes mutant
T12542 28163-28166 CC denotes and
T12541 28174-28181 NNS denotes kidneys
T12540 28157-28158 HYPH denotes -
T12539 28158-28162 NN denotes type
T12538 28153-28157 JJ denotes wild
T12537 28145-28152 IN denotes between
T12536 28134-28144 NN denotes expression
T12535 28131-28133 IN denotes in
T12534 28119-28130 NNS denotes differences
T12533 28115-28118 JJ denotes few
T12532 28110-28114 RB denotes very
T12531 28090-28096 NN denotes target
T12530 28086-28089 NN denotes Wnt
T12529 28080-28085 VBN denotes known
T12528 28097-28102 NNS denotes genes
T12527 28076-28079 DT denotes the
T12526 28074-28076 , denotes ,
T12525 28103-28109 VBD denotes showed
T12524 28064-28074 RB denotes Remarkably
T12523 28063-28193 sentence denotes Remarkably, the known Wnt target genes showed very few differences in expression between wild-type and mutant kidneys (Figure 8).
T12522 28062-28063 . denotes .
T12521 28047-28051 JJ denotes down
T12520 28052-28062 NN denotes regulation
T12519 28035-28046 JJ denotes significant
T12518 28024-28034 VB denotes illustrate
T12517 28021-28023 TO denotes to
T12516 28010-28020 NNS denotes references
T12515 28007-28009 IN denotes as
T12514 27993-27997 VBD denotes were
T12513 27998-28006 VBN denotes included
T12512 27982-27987 NN denotes probe
T12511 27976-27981 NN denotes Pygo2
T12510 27972-27975 CC denotes and
T12509 27988-27992 NNS denotes sets
T12508 27966-27971 NN denotes Pygo1
T12507 27961-27965 CC denotes Both
T12506 27960-28063 sentence denotes Both Pygo1 and Pygo2 probe sets were included as references to illustrate significant down regulation.
T12505 27959-27960 . denotes .
T12504 27954-27958 IN denotes from
T12503 27941-27944 VBD denotes was
T12502 27929-27932 NN denotes Wnt
T12501 27933-27940 NNS denotes targets
T12500 27923-27928 JJ denotes known
T12499 27920-27922 IN denotes of
T12498 27945-27953 VBN denotes compiled
T12497 27915-27919 NN denotes list
T12496 27913-27914 DT denotes A
T12495 27912-27960 sentence denotes A list of known Wnt targets was compiled from .
T12494 27911-27912 . denotes .
T12493 27895-27896 SYM denotes -
T12492 27894-27895 HYPH denotes /
T12491 27893-27894 SYM denotes -
T12490 27888-27893 NN denotes Pygo2
T12489 27887-27888 HYPH denotes /
T12488 27886-27887 SYM denotes -
T12487 27885-27886 HYPH denotes /
T12486 27884-27885 SYM denotes -
T12485 27897-27903 NN denotes mutant
T12484 27879-27884 NN denotes Pygo1
T12483 27904-27911 NNS denotes kidneys
T12482 27875-27878 DT denotes the
T12481 27872-27874 IN denotes in
T12480 27860-27863 NN denotes Wnt
T12479 27864-27871 NNS denotes targets
T12478 27854-27859 VBN denotes known
T12477 27843-27853 RB denotes previously
T12476 27840-27842 IN denotes of
T12475 27821-27828 VBN denotes altered
T12474 27812-27820 JJ denotes possible
T12473 27829-27839 NN denotes expression
T12472 27808-27811 DT denotes the
T12471 27805-27807 IN denotes in
T12470 27794-27804 JJ denotes interested
T12469 27789-27793 VBD denotes were
T12468 27786-27788 PRP denotes We
T12467 27785-27912 sentence denotes We were interested in the possible altered expression of previously known Wnt targets in the Pygo1-/-/Pygo2-/- mutant kidneys.
T12466 27784-27785 . denotes .
T12465 27783-27784 -RRB- denotes ]
T12464 27781-27783 CD denotes 28
T12463 27780-27781 -LRB- denotes [
T12462 27756-27765 NN denotes branching
T12461 27766-27779 NN denotes morphogenesis
T12460 27747-27755 JJ denotes ureteric
T12459 27738-27746 VB denotes regulate
T12458 27735-27737 TO denotes to
T12457 27724-27728 VBN denotes been
T12456 27719-27723 RB denotes also
T12455 27715-27718 VBZ denotes has
T12454 27713-27715 , denotes ,
T12453 27700-27708 JJ denotes ureteric
T12452 27690-27699 VBG denotes branching
T12451 27709-27713 NNS denotes tips
T12450 27686-27689 DT denotes the
T12449 27683-27685 IN denotes in
T12448 27673-27682 VBN denotes expressed
T12447 27669-27672 CC denotes and
T12446 27667-27669 , denotes ,
T12445 27660-27667 NNS denotes rhythms
T12444 27650-27659 JJ denotes circadian
T12443 27647-27649 IN denotes of
T12442 27636-27646 NN denotes regulation
T12441 27632-27635 DT denotes the
T12440 27629-27631 IN denotes in
T12439 27620-27628 VBN denotes involved
T12438 27599-27612 NN denotes transcription
T12437 27613-27619 NN denotes factor
T12436 27597-27598 DT denotes a
T12435 27595-27597 , denotes ,
T12434 27729-27734 VBN denotes shown
T12398 27408-27410 , denotes ,
T12397 27389-27390 HYPH denotes -
T12396 27390-27401 NN denotes angiotensin
T12395 27384-27389 NN denotes renin
T12394 27402-27408 NN denotes system
T12393 27380-27383 DT denotes the
T12392 27368-27370 , denotes ,
T12391 27367-27368 CD denotes 1
T12390 27361-27366 NN denotes Renin
T12389 27347-27360 NN denotes endopeptidase
T12388 27343-27346 DT denotes the
T12387 27340-27342 IN denotes of
T12386 27332-27339 NN denotes homolog
T12385 27330-27331 DT denotes a
T12384 27328-27330 , denotes ,
T12383 27370-27379 VBZ denotes activates
T12382 27324-27328 NN denotes Ren2
T12381 27323-27441 sentence denotes Ren2, a homolog of the endopeptidase Renin 1, activates the renin-angiotensin system, increasing blood pressure [26].
T12380 27322-27323 . denotes .
T12379 27321-27322 -RRB- denotes ]
T12378 27319-27321 CD denotes 25
T12377 27318-27319 -LRB- denotes [
T12376 27309-27317 NN denotes pressure
T12375 27303-27308 NN denotes blood
T12374 27300-27302 IN denotes of
T12373 27289-27299 NN denotes regulation
T12372 27285-27288 CC denotes and
T12371 27283-27285 , denotes ,
T12370 27273-27283 NN denotes remodeling
T12369 27266-27272 NN denotes tissue
T12368 27264-27266 , denotes ,
T12367 27258-27264 NN denotes cancer
T12366 27255-27257 IN denotes in
T12365 27245-27254 NNS denotes functions
T12364 27237-27244 JJ denotes diverse
T12363 27232-27236 VBP denotes have
T12361 27219-27323 sentence denotes Kallikreins have diverse functions in cancer, tissue remodeling, and regulation of blood pressure [25].
T12688 29487-29488 . denotes .
T12687 29472-29482 NN denotes microarray
T12686 29483-29487 NNS denotes data
T12685 29468-29471 DT denotes the
T12684 29458-29467 VBG denotes screening
T12683 29455-29457 IN denotes in
T12682 29450-29454 VBN denotes used
T12681 29435-29438 JJ denotes low
T12680 29424-29434 RB denotes relatively
T12679 29439-29449 NN denotes stringency
T12678 29420-29423 DT denotes the
T12677 29408-29419 VBG denotes considering
T12676 29406-29408 , denotes ,
T12675 29394-29396 VB denotes be
T12674 29390-29393 RB denotes not
T12673 29384-29389 MD denotes could
T12672 29373-29377 CD denotes nine
T12671 29378-29383 NNS denotes genes
T12670 29369-29372 DT denotes the
T12669 29366-29368 IN denotes of
T12668 29362-29365 CD denotes two
T12667 29397-29406 VBN denotes validated
T12666 29357-29361 IN denotes that
T12665 29346-29356 JJ denotes surprising
T12664 29342-29345 RB denotes not
T12663 29339-29341 VBZ denotes is
T12662 29336-29338 PRP denotes It
T12661 29335-29488 sentence denotes It is not surprising that two of the nine genes could not be validated, considering the relatively low stringency used in screening the microarray data.
T12660 29334-29335 . denotes .
T12659 29333-29334 -RRB- denotes )
T12658 29332-29333 CD denotes 4
T12657 29326-29331 NN denotes Table
T12656 29325-29326 -LRB- denotes (
T12655 29306-29316 NN denotes microarray
T12654 29317-29324 NNS denotes results
T12653 29302-29305 DT denotes the
T12652 29299-29301 IN denotes by
T12360 27218-27219 . denotes .
T12359 27202-27208 NN denotes serine
T12358 27209-27218 NNS denotes proteases
T12357 27196-27197 HYPH denotes -
T12356 27197-27201 JJ denotes like
T12355 27189-27196 NN denotes trypsin
T12354 27186-27188 IN denotes of
T12353 27168-27178 NN denotes kallikrein
T12352 27179-27185 NN denotes family
T12351 27164-27167 DT denotes the
T12350 27161-27163 IN denotes of
T12349 27153-27160 NNS denotes members
T12348 27144-27148 NN denotes Klk6
T12347 27140-27143 CC denotes and
T12346 27149-27152 VBP denotes are
T12345 27135-27139 NN denotes Klk5
T12344 27134-27219 sentence denotes Klk5 and Klk6 are members of the kallikrein family of trypsin-like serine proteases.
T12343 27133-27134 . denotes .
T12342 27132-27133 -RRB- denotes )
T12341 27124-27132 RB denotes 2.4-fold
T12340 27123-27124 -LRB- denotes (
T12339 27114-27122 NNP denotes Timeless
T12338 27110-27113 CC denotes and
T12337 27108-27110 , denotes ,
T12336 27107-27108 -RRB- denotes )
T12335 27099-27107 RB denotes 2.2-fold
T12334 27098-27099 -LRB- denotes (
T12333 27093-27097 NN denotes Ren2
T12332 27091-27093 , denotes ,
T12331 27090-27091 -RRB- denotes )
T12330 27082-27090 RB denotes 2.7-fold
T12329 27081-27082 -LRB- denotes (
T12328 27076-27080 NN denotes Klk6
T12327 27074-27076 , denotes ,
T12326 27073-27074 -RRB- denotes )
T12325 27065-27073 RB denotes 2.8-fold
T12324 27064-27065 -LRB- denotes (
T12323 27059-27063 NN denotes Klk5
T12322 27038-27042 JJ denotes null
T12321 27031-27032 HYPH denotes /
T12320 27032-27037 NN denotes Pygo2
T12319 27026-27031 NN denotes Pygo1
T12318 27043-27049 NN denotes kidney
T12317 27022-27025 DT denotes the
T12287 24853-24854 -RRB- denotes ]
T12286 24851-24853 CD denotes 24
T12285 24850-24851 -LRB- denotes [
T12284 24837-24842 JJ denotes adult
T12283 24843-24849 NN denotes kidney
T12282 24833-24836 DT denotes the
T12281 24830-24832 IN denotes of
T12280 24822-24829 NNS denotes tubules
T12279 24818-24821 DT denotes the
T12278 24815-24817 IN denotes in
T12277 24796-24804 RB denotes strongly
T12276 24791-24795 RB denotes also
T12275 24788-24790 VBZ denotes is
T12274 24786-24788 , denotes ,
T12273 24779-24786 NN denotes Slco1a4
T12272 24777-24779 , denotes ,
T12271 24805-24814 VBN denotes expressed
T12270 24760-24765 NN denotes anion
T12269 24752-24759 JJ denotes organic
T12268 24766-24777 NN denotes transporter
T12267 24748-24751 DT denotes The
T12266 24747-24855 sentence denotes The organic anion transporter, Slco1a4, is also strongly expressed in the tubules of the adult kidney [24].
T12265 24746-24747 . denotes .
T12264 24745-24746 -RRB- denotes ]
T12263 24743-24745 CD denotes 23
T12262 24742-24743 -LRB- denotes [
T12261 24734-24741 NN denotes nephron
T12260 24730-24733 DT denotes the
T12259 24727-24729 IN denotes by
T12258 24720-24726 NN denotes uptake
T12257 24712-24719 NN denotes glucose
T12256 24709-24711 IN denotes of
T12255 24704-24708 NN denotes loss
T12254 24701-24703 IN denotes by
T12253 24687-24700 VBN denotes characterized
T12252 24685-24687 , denotes ,
T12251 24669-24674 JJ denotes renal
T12250 24675-24685 NN denotes glucosuria
T12249 24659-24668 JJ denotes recessive
T12248 24649-24658 JJ denotes autosomal
T12247 24646-24648 IN denotes in
T12246 24630-24634 VBN denotes been
T12245 24635-24645 VBN denotes implicated
T12244 24626-24629 VBZ denotes has
T12243 24622-24625 CC denotes and
T12242 24608-24613 JJ denotes adult
T12241 24614-24621 NN denotes nephron
T12240 24604-24607 DT denotes the
T12239 24601-24603 IN denotes of
T12238 24584-24592 JJ denotes proximal
T12237 24593-24600 NNS denotes tubules
T12236 24580-24583 DT denotes the
T12235 24577-24579 IN denotes in
T12234 24564-24566 VBZ denotes is
T12233 24567-24576 VBN denotes expressed
T12232 24557-24563 NN denotes Slc5a2
T12231 24556-24747 sentence denotes Slc5a2 is expressed in the proximal tubules of the adult nephron and has been implicated in autosomal recessive renal glucosuria, characterized by loss of glucose uptake by the nephron [23].
T12230 24555-24556 . denotes .
T12229 24554-24555 -RRB- denotes )
T12228 24544-24545 SYM denotes -
T12227 24546-24554 RB denotes 2.1-fold
T12226 24543-24544 -LRB- denotes (
T12225 24535-24542 NN denotes Slco1a4
T12224 24531-24534 CC denotes and
T12223 24529-24531 , denotes ,
T12222 24528-24529 -RRB- denotes )
T12221 24518-24519 SYM denotes -
T12220 24520-24528 RB denotes 2.8-fold
T12219 24517-24518 -LRB- denotes (
T12218 24510-24516 NN denotes Slc5a2
T12217 24508-24510 , denotes ,
T12216 24507-24508 -RRB- denotes )
T12214 24499-24507 RB denotes 2.3-fold
T12213 24496-24497 -LRB- denotes (
T12212 24489-24495 NN denotes Cxcl13
T12211 24472-24479 NNS denotes kidneys
T12210 24465-24471 NN denotes mutant
T12209 24462-24464 IN denotes in
T12208 24452-24461 NNS denotes decreases
T12207 24440-24451 JJ denotes significant
T12206 24435-24439 IN denotes with
T12205 24480-24488 VBD denotes included
T12204 24429-24434 NNS denotes genes
T12203 24423-24428 JJ denotes Other
T12202 24422-24556 sentence denotes Other genes with significant decreases in mutant kidneys included Cxcl13 (- 2.3-fold), Slc5a2 (- 2.8-fold), and Slco1a4 (- 2.1-fold).
T12201 24421-24422 . denotes .
T12200 24407-24413 NN denotes mutant
T12199 24414-24421 NNS denotes kidneys
T12198 24403-24406 DT denotes the
T12197 24400-24402 IN denotes in
T12196 24398-24399 -RRB- denotes )
T12195 24384-24386 , denotes ,
T12194 24376-24384 RB denotes 3.9-fold
T12193 24374-24375 SYM denotes -
T12192 24370-24373 CC denotes and
T12191 24361-24369 RB denotes 5.3-fold
T12190 24359-24360 SYM denotes -
T12189 24386-24398 RB denotes respectively
T12188 24358-24359 -LRB- denotes (
T12187 24344-24357 VBN denotes downregulated
T12186 24341-24343 IN denotes as
T12185 24325-24329 VBD denotes were
T12184 24319-24324 NN denotes Pygo2
T12183 24315-24318 CC denotes and
T12433 27587-27595 NN denotes Timeless
T12432 27586-27785 sentence denotes Timeless, a transcription factor involved in the regulation of circadian rhythms, and expressed in the branching ureteric tips, has also been shown to regulate ureteric branching morphogenesis [28].
T12431 27585-27586 . denotes .
T12430 27584-27585 -RRB- denotes ]
T12429 27582-27584 CD denotes 27
T12428 27581-27582 -LRB- denotes [
T12427 27574-27580 NN denotes system
T12426 27568-27569 HYPH denotes -
T12425 27569-27573 NN denotes duct
T12424 27558-27568 NN denotes collecting
T12423 27554-27557 CC denotes and
T12422 27547-27553 NN denotes ureter
T12421 27543-27546 DT denotes the
T12420 27540-27542 IN denotes of
T12419 27526-27539 NNS denotes abnormalities
T12418 27515-27525 JJ denotes congenital
T12417 27512-27514 IN denotes in
T12416 27492-27503 NN denotes development
T12415 27485-27491 IN denotes during
T12414 27465-27466 HYPH denotes -
T12413 27466-27477 NN denotes angiotensin
T12412 27460-27465 NN denotes renin
T12411 27478-27484 NN denotes system
T12410 27456-27459 DT denotes the
T12409 27453-27455 IN denotes of
T12408 27504-27511 VBZ denotes results
T12407 27442-27452 NN denotes Disruption
T12406 27441-27586 sentence denotes Disruption of the renin-angiotensin system during development results in congenital abnormalities of the ureter and collecting-duct system [27].
T12405 27440-27441 . denotes .
T12404 27439-27440 -RRB- denotes ]
T12403 27437-27439 CD denotes 26
T12402 27436-27437 -LRB- denotes [
T12401 27427-27435 NN denotes pressure
T12400 27421-27426 NN denotes blood
T12399 27410-27420 VBG denotes increasing
T12167 24265-24268 CC denotes and
T12166 24263-24265 , denotes ,
T12165 24259-24263 CD denotes 0.05
T12164 24258-24259 SYM denotes <
T12163 24255-24257 IN denotes of
T12162 24241-24242 HYPH denotes -
T12161 24242-24247 NN denotes value
T12160 24240-24241 NN denotes p
T12159 24248-24254 NN denotes cutoff
T12158 24238-24239 DT denotes a
T12157 24233-24237 IN denotes with
T12156 24231-24233 , denotes ,
T12155 24227-24231 NNS denotes data
T12154 24223-24226 DT denotes the
T12153 24220-24222 IN denotes of
T12152 24202-24212 NN denotes stringency
T12151 24198-24201 JJ denotes low
T12150 24187-24197 RB denotes relatively
T12149 24213-24219 NN denotes screen
T12148 24185-24186 DT denotes a
T12147 24179-24184 VBG denotes using
T12146 24177-24179 , denotes ,
T12145 24170-24177 VBN denotes changed
T12144 24156-24169 RB denotes significantly
T12143 24153-24155 IN denotes as
T12142 24137-24141 VBD denotes were
T12141 24131-24136 NNS denotes genes
T12140 24128-24130 CD denotes 45
T12139 24126-24128 , denotes ,
T12138 24121-24126 JJ denotes total
T12137 24142-24152 VBN denotes identified
T12136 24118-24120 IN denotes In
T12135 24117-24294 sentence denotes In total, 45 genes were identified as significantly changed, using a relatively low stringency screen of the data, with a p-value cutoff of <0.05, and fold change >2 (Table 3).
T12134 24116-24117 . denotes .
T12133 24106-24116 NN denotes triplicate
T12132 24095-24105 JJ denotes biological
T12131 24092-24094 IN denotes in
T12130 24078-24082 VBD denotes were
T12129 24083-24091 VBN denotes examined
T12128 24068-24069 SYM denotes -
T12127 24067-24068 HYPH denotes /
T12126 24066-24067 SYM denotes -
T12125 24061-24066 NN denotes Pygo2
T12124 24060-24061 HYPH denotes /
T12123 24059-24060 SYM denotes -
T12122 24058-24059 HYPH denotes /
T12121 24057-24058 SYM denotes -
T12120 24052-24057 NN denotes Pygo1
T12119 24048-24051 CC denotes and
T12118 24042-24043 HYPH denotes -
T12117 24043-24047 NN denotes type
T12116 24038-24042 JJ denotes wild
T12115 24070-24077 NNS denotes kidneys
T12114 24032-24037 NN denotes E18.5
T12113 24031-24117 sentence denotes E18.5 wild-type and Pygo1-/-/Pygo2-/- kidneys were examined in biological triplicate.
T12112 24030-24031 . denotes .
T12111 24019-24022 NN denotes Wnt
T12110 24013-24018 VBN denotes known
T12109 24023-24030 NNS denotes targets
T12108 24009-24012 DT denotes all
T12107 23999-24008 VBG denotes including
T12106 23997-23999 , denotes ,
T12105 23992-23997 NNS denotes genes
T12104 23988-23991 DT denotes all
T12103 23985-23987 IN denotes of
T12102 23977-23984 NNS denotes changes
T12101 23966-23976 NN denotes expression
T12100 23959-23965 VB denotes follow
T12099 23956-23958 TO denotes to
T12098 23948-23950 VB denotes be
T12097 23944-23947 MD denotes can
T12096 23932-23943 NNS denotes microarrays
T12095 23930-23932 , denotes ,
T12094 23921-23930 NN denotes signaling
T12093 23917-23920 NN denotes Wnt
T12092 23914-23916 IN denotes to
T12091 23905-23913 NN denotes promoter
T12090 23901-23904 CD denotes one
T12089 23898-23900 IN denotes of
T12088 23889-23897 NN denotes response
T12087 23885-23888 DT denotes the
T12086 23951-23955 VBN denotes used
T12085 23857-23866 NN denotes transgene
T12084 23852-23853 HYPH denotes -
T12083 23853-23856 NN denotes gal
T12082 23849-23852 NN denotes BAT
T12081 23867-23875 NN denotes reporter
T12080 23845-23848 DT denotes the
T12079 23876-23884 VBZ denotes monitors
T12078 23837-23844 IN denotes Whereas
T12077 23836-24031 sentence denotes Whereas the BAT-gal transgene reporter monitors the response of one promoter to Wnt signaling, microarrays can be used to follow expression changes of all genes, including all known Wnt targets.
T12076 23835-23836 . denotes .
T12075 23828-23835 NNS denotes changes
T12074 23817-23827 NN denotes expression
T12073 23812-23816 NN denotes gene
T12072 23809-23811 IN denotes of
T12071 23793-23799 JJ denotes global
T12070 23800-23808 NN denotes analysis
T12069 23791-23792 DT denotes a
T12068 23783-23790 VB denotes perform
T12067 23780-23782 TO denotes to
T12066 23768-23779 NNS denotes microarrays
T12065 23760-23762 PRP denotes we
T12064 23758-23760 , denotes ,
T12063 23744-23750 NN denotes mutant
T12062 23737-23738 HYPH denotes /
T12061 23738-23743 NN denotes Pygo2
T12060 23732-23737 NN denotes Pygo1
T12059 23751-23758 NNS denotes kidneys
T12058 23728-23731 DT denotes the
T12057 23725-23727 IN denotes in
T12056 23714-23724 NN denotes expression
T12055 23709-23713 NN denotes gene
T12054 23706-23708 IN denotes of
T12053 23694-23705 NN denotes disturbance
T12052 23685-23693 JJ denotes possible
T12051 23763-23767 VBD denotes used
T12050 23669-23676 RB denotes further
T12049 23677-23684 VB denotes examine
T12048 23666-23668 TO denotes To
T12047 23665-23836 sentence denotes To further examine possible disturbance of gene expression in the Pygo1/Pygo2 mutant kidneys, we used microarrays to perform a global analysis of gene expression changes.
T12046 23658-23665 NNS denotes kidneys
T12045 23653-23657 JJ denotes null
T12044 23646-23647 HYPH denotes /
T12043 23647-23652 NN denotes Pygo2
T12042 23641-23646 NN denotes Pygo1
T12041 23638-23640 IN denotes of
T12040 23629-23637 NN denotes analysis
T12039 23618-23628 NN denotes Microarray
T12182 24309-24314 NN denotes Pygo1
T12181 24304-24308 CC denotes both
T12180 24302-24304 , denotes ,
T12179 24330-24340 VBN denotes identified
T12178 24295-24302 RB denotes Notably
T12177 24294-24422 sentence denotes Notably, both Pygo1 and Pygo2 were identified as downregulated (- 5.3-fold and - 3.9-fold, respectively) in the mutant kidneys.
T12176 24293-24294 . denotes .
T12175 24292-24293 -RRB- denotes )
T12174 24291-24292 CD denotes 3
T12173 24285-24290 NN denotes Table
T12172 24284-24285 -LRB- denotes (
T12171 24282-24283 CD denotes 2
T12170 24281-24282 SYM denotes >
T12169 24274-24280 NN denotes change
T12168 24269-24273 NN denotes fold
T10604 23615-23616 . denotes .
T10603 23598-23608 VBG denotes developing
T10602 23609-23615 NN denotes kidney
T10601 23594-23597 DT denotes the
T10600 23591-23593 IN denotes of
T10599 23568-23579 JJ denotes metanephric
T10598 23580-23590 NN denotes mesenchyme
T10597 23564-23567 DT denotes the
T10596 23561-23563 IN denotes in
T10595 23547-23550 NN denotes Wnt
T10594 23551-23560 NN denotes signaling
T10593 23537-23546 JJ denotes canonical
T10592 23534-23536 IN denotes of
T10591 23516-23524 JJ denotes accurate
T10590 23525-23533 NN denotes reporter
T10589 23513-23515 DT denotes an
T10588 23509-23512 RB denotes not
T10587 23496-23505 NN denotes transgene
T10586 23491-23495 DT denotes this
T10585 23506-23508 VBZ denotes is
T10584 23486-23490 IN denotes that
T10583 23475-23485 VBG denotes suggesting
T10582 23473-23475 , denotes ,
T10581 23472-23473 -RRB- denotes )
T10580 23463-23466 RB denotes not
T10579 23458-23462 NNS denotes data
T10578 23467-23472 VBN denotes shown
T10577 23457-23458 -LRB- denotes (
T10576 23446-23456 NN denotes expression
T10575 23441-23442 HYPH denotes -
T10574 23442-23445 NN denotes gal
T10573 23438-23441 NN denotes BAT
T10572 23433-23437 VB denotes show
T10571 23430-23432 TO denotes to
T10570 23423-23429 VBD denotes failed
T10569 23419-23422 CC denotes but
T10568 23417-23419 , denotes ,
T10567 23409-23417 VBN denotes expected
T10566 23406-23408 IN denotes as
T10565 23404-23406 , denotes ,
T10564 23391-23404 NN denotes nephrogenesis
T10563 23379-23382 VBD denotes did
T10562 23356-23367 JJ denotes metanephric
T10561 23368-23378 NN denotes mesenchyme
T10560 23347-23348 HYPH denotes -
T10559 23348-23355 VBN denotes treated
T10558 23343-23347 NN denotes LiCl
T10557 23383-23390 VB denotes undergo
T10556 23338-23342 IN denotes that
T10555 23329-23337 VBD denotes observed
T10554 23326-23328 PRP denotes We
T10553 23325-23616 sentence denotes We observed that LiCl-treated metanephric mesenchyme did undergo nephrogenesis, as expected, but failed to show BAT-gal expression (data not shown), suggesting that this transgene is not an accurate reporter of canonical Wnt signaling in the metanephric mesenchyme of the developing kidney.
T10552 23324-23325 . denotes .
T10551 23323-23324 -RRB- denotes ]
T10550 23321-23323 CD denotes 22
T10549 23320-23321 -LRB- denotes [
T10548 23312-23319 NN denotes culture
T10547 23306-23311 NN denotes organ
T10546 23299-23305 NN denotes kidney
T10545 23296-23298 IN denotes in
T10544 23282-23295 NN denotes nephrogenesis
T10543 23279-23281 IN denotes of
T10542 23271-23278 NN denotes inducer
T10541 23268-23270 DT denotes an
T10540 23265-23267 IN denotes as
T10539 23255-23264 VBZ denotes functions
T10538 23250-23254 RB denotes also
T10537 23246-23249 CC denotes and
T10536 23244-23246 , denotes ,
T10535 23240-23244 NN denotes GSK3
T10534 23237-23239 IN denotes of
T10533 23226-23236 NN denotes inhibition
T10532 23218-23225 IN denotes through
T10531 23204-23207 NN denotes Wnt
T10530 23208-23217 NN denotes signaling
T10529 23194-23203 JJ denotes canonical
T10528 23184-23193 VBZ denotes activates
T10527 23178-23183 WDT denotes which
T10526 23176-23178 , denotes ,
T10525 23175-23176 -RRB- denotes )
T10524 23171-23175 NN denotes LiCl
T10523 23170-23171 -LRB- denotes (
T10522 23161-23169 NN denotes chloride
T10521 23153-23160 NN denotes lithium
T10520 23150-23152 IN denotes in
T10519 23127-23138 JJ denotes metanephric
T10518 23139-23149 NN denotes mesenchyme
T10517 23121-23126 NN denotes E11.5
T10516 23108-23110 PRP denotes we
T10515 23106-23108 , denotes ,
T10514 23098-23106 NN denotes question
T10513 23093-23097 DT denotes this
T10512 23111-23120 VBD denotes incubated
T10511 23085-23092 VB denotes address
T10510 23082-23084 TO denotes To
T10509 23081-23325 sentence denotes To address this question, we incubated E11.5 metanephric mesenchyme in lithium chloride (LiCl), which activates canonical Wnt signaling through inhibition of GSK3, and also functions as an inducer of nephrogenesis in kidney organ culture [22].
T10508 23080-23081 . denotes .
T10507 23058-23069 JJ denotes metanephric
T10506 23070-23080 NN denotes mesenchyme
T10505 23054-23057 DT denotes the
T10504 23051-23053 IN denotes in
T10503 23037-23040 NN denotes Wnt
T10502 23041-23050 NN denotes signaling
T10501 23027-23036 JJ denotes canonical
T10500 23009-23019 RB denotes accurately
T10499 23005-23008 RB denotes not
T10498 22999-23004 MD denotes might
T10497 22984-22985 HYPH denotes -
T10496 22985-22988 NN denotes gal
T10495 22981-22984 NN denotes BAT
T10494 22989-22998 NN denotes transgene
T10493 22977-22980 DT denotes the
T10492 23020-23026 VB denotes report
T10491 22972-22976 IN denotes that
T10490 22963-22971 VBZ denotes suggests
T10489 22958-22962 DT denotes This
T10488 22957-23081 sentence denotes This suggests that the BAT-gal transgene might not accurately report canonical Wnt signaling in the metanephric mesenchyme.
T10487 22956-22957 . denotes .
T10486 22955-22956 -RRB- denotes ]
T10485 22954-22955 CD denotes 2
T10484 22953-22954 -LRB- denotes [
T10483 22930-22941 JJ denotes metanephric
T10482 22942-22952 NN denotes mesenchyme
T10481 22926-22929 DT denotes the
T10480 22923-22925 IN denotes of
T10479 22909-22922 NN denotes nephrogenesis
T10478 22902-22908 VB denotes induce
T10477 22898-22901 CC denotes and
T10476 22890-22897 NNS denotes mutants
T10475 22884-22889 NN denotes Wnt9b
T10474 22873-22876 MD denotes can
T10473 22871-22873 , denotes ,
T10472 22858-22861 NN denotes Wnt
T10471 22862-22871 NN denotes signaling
T10470 22848-22857 JJ denotes canonical
T10469 22840-22847 IN denotes through
T10468 22836-22839 VB denotes act
T10467 22833-22835 TO denotes to
T10466 22825-22832 VBN denotes thought
T10465 22823-22825 , denotes ,
T10464 22819-22823 NN denotes Wnt1
T10463 22816-22818 IN denotes of
T10462 22805-22815 NN denotes expression
T10461 22801-22804 NN denotes bud
T10460 22792-22800 JJ denotes ureteric
T10459 22790-22792 , denotes ,
T10458 22783-22790 NN denotes example
T10457 22877-22883 VB denotes rescue
T10456 22779-22782 IN denotes For
T10455 22778-22957 sentence denotes For example, ureteric bud expression of Wnt1, thought to act through canonical Wnt signaling, can rescue Wnt9b mutants and induce nephrogenesis of the metanephric mesenchyme [2].
T10454 22777-22778 . denotes .
T10453 22755-22766 JJ denotes metanephric
T10452 22767-22777 NN denotes mesenchyme
T10451 22751-22754 DT denotes the
T10450 22748-22750 IN denotes in
T10449 22734-22737 NN denotes Wnt
T10448 22738-22747 NN denotes signaling
T10447 22724-22733 JJ denotes canonical
T10446 22721-22723 IN denotes of
T10445 22712-22720 NN denotes presence
T10444 22708-22711 DT denotes the
T10443 22704-22707 IN denotes for
T10442 22696-22698 , denotes ,
T10441 22689-22696 RB denotes however
T10440 22687-22689 , denotes ,
T10439 22680-22687 NNS denotes studies
T10438 22674-22679 JJ denotes other
T10437 22669-22673 IN denotes from
T10436 22698-22703 VBP denotes argue
T10435 22661-22668 NNS denotes Results
T10434 22660-22778 sentence denotes Results from other studies, however, argue for the presence of canonical Wnt signaling in the metanephric mesenchyme.
T10433 22659-22660 . denotes .
T10432 22658-22659 -RRB- denotes ]
T10431 22656-22658 CD denotes 21
T10430 22655-22656 -LRB- denotes [
T10429 22632-22643 JJ denotes metanephric
T10428 22644-22654 NN denotes mesenchyme
T10427 22628-22631 DT denotes the
T10426 22625-22627 IN denotes in
T10425 22611-22614 NN denotes Wnt
T10424 22615-22624 NN denotes signaling
T10423 22601-22610 JJ denotes canonical
T10422 22598-22600 IN denotes of
T10421 22590-22597 NN denotes absence
T10420 22586-22589 DT denotes the
T10419 22577-22585 VB denotes indicate
T10418 22574-22576 TO denotes to
T10417 22562-22573 VBN denotes interpreted
T10416 22558-22561 VBD denotes was
T10415 22554-22557 CC denotes and
T10414 22552-22554 , denotes ,
T10353 21671-21673 IN denotes of
T10352 21659-21670 NN denotes development
T10351 21652-21658 IN denotes during
T10350 21638-21641 NN denotes Wnt
T10349 21642-21651 NN denotes signaling
T10348 21628-21637 JJ denotes canonical
T10347 21625-21627 IN denotes in
T10346 21613-21618 NN denotes Pygo2
T10345 21609-21612 CC denotes and
T10344 21603-21608 NN denotes Pygo1
T10343 21619-21624 NNS denotes genes
T10342 21599-21602 DT denotes the
T10341 21595-21598 IN denotes for
T10340 21578-21589 JJ denotes significant
T10339 21590-21594 NN denotes role
T10338 21576-21577 DT denotes a
T10337 21551-21559 NN denotes reporter
T10336 21546-21547 HYPH denotes -
T10335 21547-21550 NN denotes gal
T10334 21543-21546 NN denotes BAT
T10333 21560-21567 NNS denotes results
T10332 21537-21542 DT denotes these
T10331 21535-21537 , denotes ,
T10330 21568-21575 VBP denotes suggest
T10329 21523-21535 RB denotes Collectively
T10328 21522-21706 sentence denotes Collectively, these BAT-gal reporter results suggest a significant role for the Pygo1 and Pygo2 genes in canonical Wnt signaling during development of the ureteric tree of the kidney.
T10327 21521-21522 . denotes .
T10326 21520-21521 -RRB- denotes )
T10325 21511-21514 RB denotes not
T10324 21506-21510 NNS denotes data
T10323 21515-21520 VBN denotes shown
T10322 21505-21506 -LRB- denotes (
T10321 21495-21496 SYM denotes +
T10320 21494-21495 HYPH denotes /
T10319 21493-21494 SYM denotes +
T10318 21488-21493 NN denotes Pygo2
T10317 21487-21488 HYPH denotes /
T10316 21486-21487 SYM denotes -
T10315 21485-21486 HYPH denotes /
T10314 21484-21485 SYM denotes -
T10313 21497-21504 NNS denotes kidneys
T10312 21479-21484 NN denotes Pygo1
T10311 21474-21478 IN denotes with
T10310 21465-21473 VBN denotes compared
T10309 21460-21464 NN denotes area
T10308 21456-21459 IN denotes per
T10307 21449-21455 NN denotes number
T10306 21445-21448 NN denotes tip
T10305 21436-21444 JJ denotes ureteric
T10304 21433-21435 IN denotes in
T10303 21425-21432 NNS denotes changes
T10302 21413-21424 JJ denotes significant
T10301 21410-21412 CC denotes or
T10300 21396-21404 JJ denotes ureteric
T10299 21388-21395 JJ denotes dilated
T10298 21405-21409 NNS denotes tips
T10297 21385-21387 DT denotes no
T10296 21367-21375 NN denotes genotype
T10295 21362-21366 DT denotes this
T10294 21357-21361 IN denotes with
T10293 21349-21356 NNS denotes kidneys
T10292 21346-21348 IN denotes of
T10291 21337-21345 NN denotes analysis
T10290 21328-21336 JJ denotes confocal
T10272 21259-21260 HYPH denotes -
T10271 21260-21263 NN denotes gal
T10270 21256-21259 NN denotes BAT
T10269 21279-21288 VBN denotes decreased
T10268 21247-21255 IN denotes Although
T10267 21246-21522 sentence denotes Although BAT-gal expression was decreased in the E18.5 Pygo1-/-/Pygo2+/- kidney, confocal analysis of kidneys with this genotype revealed no dilated ureteric tips or significant changes in ureteric tip number per area compared with Pygo1-/-/Pygo2+/+ kidneys (data not shown).
T10266 21245-21246 . denotes .
T10265 21232-21235 NN denotes Wnt
T10264 21236-21245 NN denotes signaling
T10263 21222-21231 JJ denotes canonical
T10262 21219-21221 IN denotes in
T10261 21213-21218 NN denotes Pygo1
T10260 21210-21212 IN denotes by
T10259 21191-21196 JJ denotes minor
T10258 21197-21209 NN denotes contribution
T10257 21189-21190 DT denotes a
T10256 21178-21188 VBG denotes suggesting
T10255 21176-21178 , denotes ,
T10254 21161-21162 HYPH denotes -
T10253 21162-21165 NN denotes gal
T10252 21158-21161 NN denotes BAT
T10251 21166-21176 NN denotes expression
T10250 21152-21153 HYPH denotes -
T10249 21153-21157 NN denotes type
T10248 21148-21152 JJ denotes wild
T10247 21145-21147 IN denotes of
T10246 21143-21144 NN denotes %
T10245 21141-21143 CD denotes 50
T10244 21136-21140 RB denotes only
T10243 21127-21128 SYM denotes -
T10242 21126-21127 HYPH denotes /
T10241 21125-21126 SYM denotes +
T10240 21120-21125 NN denotes Pygo2
T10239 21119-21120 HYPH denotes /
T10238 21118-21119 SYM denotes -
T10237 21117-21118 HYPH denotes /
T10236 21116-21117 SYM denotes -
T10235 21111-21116 NN denotes Pygo1
T10234 21107-21110 DT denotes the
T10233 21105-21107 , denotes ,
T10232 21098-21105 RB denotes however
T10231 21096-21098 , denotes ,
T10230 21129-21135 VBD denotes showed
T10229 21083-21096 RB denotes Interestingly
T10228 21082-21246 sentence denotes Interestingly, however, the Pygo1-/-/Pygo2+/- showed only 50% of wild-type BAT-gal expression, suggesting a minor contribution by Pygo1 in canonical Wnt signaling.
T10227 21081-21082 . denotes .
T10226 21063-21074 JJ denotes significant
T10225 21075-21081 NN denotes change
T10224 21061-21062 DT denotes a
T10223 21058-21060 IN denotes in
T10222 21047-21050 RB denotes not
T10221 21043-21046 VBD denotes did
T10220 21041-21042 -RRB- denotes )
T10219 21040-21041 SYM denotes +
T10218 21039-21040 HYPH denotes /
T10217 21038-21039 SYM denotes +
T10216 21033-21038 NN denotes Pygo2
T10215 21032-21033 HYPH denotes /
T10214 21031-21032 SYM denotes -
T10213 21030-21031 HYPH denotes /
T10212 21029-21030 SYM denotes -
T10211 21024-21029 NN denotes Pygo1
T10210 21023-21024 -LRB- denotes (
T10209 21017-21022 RB denotes alone
T10208 21011-21016 NN denotes Pygo1
T10207 21008-21010 IN denotes of
T10206 21051-21057 VB denotes result
T10205 21003-21007 NN denotes Loss
T10204 21002-21082 sentence denotes Loss of Pygo1 alone (Pygo1-/-/Pygo2+/+) did not result in a significant change.
T10203 21001-21002 . denotes .
T10202 20991-21001 NN denotes expression
T10201 20986-20987 HYPH denotes -
T10200 20987-20990 NN denotes gal
T10199 20983-20986 NN denotes BAT
T10198 20980-20982 IN denotes in
T10197 20970-20979 NN denotes reduction
T10196 20968-20969 NN denotes %
T10195 20961-20965 IN denotes than
T10194 20966-20968 CD denotes 90
T10193 20953-20960 JJR denotes greater
T10192 20946-20947 -RRB- denotes )
T10191 20945-20946 SYM denotes -
T10190 20944-20945 HYPH denotes /
T10189 20943-20944 SYM denotes -
T10188 20938-20943 NN denotes Pygo2
T10187 20937-20938 HYPH denotes /
T10186 20936-20937 SYM denotes -
T10185 20935-20936 HYPH denotes /
T10184 20934-20935 SYM denotes -
T10183 20929-20934 NN denotes Pygo1
T10182 20925-20928 CC denotes and
T10181 20923-20924 SYM denotes -
T10180 20922-20923 HYPH denotes /
T10179 20921-20922 SYM denotes -
T10178 20916-20921 NN denotes Pygo2
T10177 20915-20916 HYPH denotes /
T10176 20914-20915 SYM denotes -
T10175 20913-20914 HYPH denotes /
T10174 20912-20913 SYM denotes +
T10173 20907-20912 NN denotes Pygo1
T10172 20906-20907 -LRB- denotes (
T10171 20895-20900 NN denotes Pygo2
T10170 20901-20905 NN denotes gene
T10169 20891-20894 DT denotes the
T10168 20888-20890 IN denotes of
T10167 20948-20952 VBD denotes gave
T10166 20883-20887 NN denotes Loss
T10165 20882-21002 sentence denotes Loss of the Pygo2 gene (Pygo1+/-/Pygo2-/- and Pygo1-/-/Pygo2-/-) gave greater than 90% reduction in BAT-gal expression.
T10164 20881-20882 . denotes .
T10163 20880-20881 -RRB- denotes )
T10162 20879-20880 CD denotes 7
T10161 20872-20878 NN denotes Figure
T10160 20871-20872 -LRB- denotes (
T10159 20863-20870 NNS denotes kidneys
T10158 20857-20862 NN denotes E18.5
T10157 20854-20856 IN denotes in
T10156 20832-20833 HYPH denotes -
T10155 20833-20846 NN denotes galactosidase
T10154 20831-20832 NN denotes β
T10153 20847-20853 NNS denotes levels
T10152 20822-20830 JJ denotes specific
T10151 20812-20821 NN denotes transgene
T10150 20809-20811 IN denotes of
T10149 20796-20808 NNS denotes measurements
T10148 20790-20795 NN denotes ELISA
T10147 20777-20779 PRP denotes we
T10146 20775-20777 , denotes ,
T10145 20770-20775 NNS denotes nulls
T10144 20763-20764 HYPH denotes /
T10143 20764-20769 NN denotes Pygo2
T10142 20758-20763 NN denotes Pygo1
T10141 20754-20757 CC denotes and
T10140 20743-20748 NN denotes Pygo2
T10139 20749-20753 NN denotes null
T10138 20739-20742 DT denotes the
T10136 20717-20727 NN denotes expression
T10135 20708-20716 NN denotes reporter
T10134 20703-20704 HYPH denotes -
T10133 20704-20707 NN denotes gal
T10132 20700-20703 NN denotes BAT
T10131 20728-20735 NNS denotes changes
T10130 20696-20699 DT denotes the
T10129 20687-20695 VB denotes quantify
T10128 20683-20686 CC denotes and
T10127 20674-20682 VB denotes validate
T10126 20671-20673 TO denotes to
T10125 20665-20670 NN denotes order
T10124 20780-20789 VBD denotes performed
T10123 20662-20664 IN denotes In
T10122 20661-20882 sentence denotes In order to validate and quantify the BAT-gal reporter expression changes in the Pygo2 null and Pygo1/Pygo2 nulls, we performed ELISA measurements of transgene specific β-galactosidase levels in E18.5 kidneys (Figure 7).
T10121 20660-20661 . denotes .
T10120 20649-20660 NNS denotes derivatives
T10119 20645-20648 PRP$ denotes its
T10118 20641-20644 CC denotes and
T10117 20627-20635 JJ denotes ureteric
T10116 20636-20640 NN denotes tree
T10115 20623-20626 DT denotes the
T10114 20620-20622 IN denotes in
T10113 20606-20609 NN denotes Wnt
T10112 20610-20619 NN denotes signaling
T10111 20596-20605 JJ denotes canonical
T10110 20593-20595 IN denotes in
T10109 20582-20587 NN denotes Pygo2
T10108 20588-20592 NN denotes gene
T10107 20578-20581 DT denotes the
T10106 20574-20577 IN denotes for
T10105 20557-20568 JJ denotes significant
T10104 20569-20573 NN denotes role
T10103 20555-20556 DT denotes a
T10102 20531-20536 NN denotes E18.5
T10101 20529-20530 -RRB- denotes )
T10100 20522-20524 , denotes ,
T10099 20520-20522 NN denotes 6O
T10413 22542-22552 RB denotes previously
T10412 22528-22532 VBN denotes been
T10411 22524-22527 VBZ denotes has
T10410 22533-22541 VBN denotes reported
T10409 22519-22523 DT denotes This
T10408 22518-22660 sentence denotes This has been reported previously, and was interpreted to indicate the absence of canonical Wnt signaling in the metanephric mesenchyme [21].
T10407 22517-22518 . denotes .
T10406 22508-22517 NNS denotes glomeruli
T10405 22504-22507 CC denotes and
T10404 22502-22504 , denotes ,
T10403 22495-22502 NNS denotes tubules
T10402 22493-22495 , denotes ,
T10401 22487-22493 NNS denotes bodies
T10400 22479-22480 HYPH denotes -
T10399 22480-22486 VBN denotes shaped
T10398 22478-22479 NN denotes S
T10397 22476-22478 , denotes ,
T10396 22468-22476 NNS denotes vesicles
T10395 22462-22467 JJ denotes renal
T10394 22459-22461 IN denotes as
T10393 22454-22458 JJ denotes such
T10392 22452-22454 , denotes ,
T10391 22442-22452 NNS denotes structures
T10390 22433-22434 HYPH denotes -
T10389 22434-22441 VBN denotes derived
T10388 22423-22433 NN denotes mesenchyme
T10387 22411-22422 JJ denotes metanephric
T10386 22408-22410 CC denotes or
T10385 22406-22408 , denotes ,
T10384 22384-22395 JJ denotes metanephric
T10383 22373-22383 VBG denotes developing
T10382 22396-22406 NN denotes mesenchyme
T10381 22369-22372 DT denotes the
T10380 22366-22368 IN denotes in
T10379 22355-22365 NN denotes expression
T10378 22352-22354 DT denotes no
T10377 22331-22332 HYPH denotes -
T10376 22332-22335 NN denotes gal
T10375 22328-22331 NN denotes BAT
T10374 22336-22344 NN denotes reporter
T10373 22324-22327 DT denotes the
T10372 22319-22323 NNS denotes mice
T10371 22313-22314 HYPH denotes -
T10370 22314-22318 NN denotes type
T10369 22309-22313 JJ denotes wild
T10368 22306-22308 IN denotes in
T10367 22301-22305 RB denotes even
T10360 21705-21706 . denotes .
T10359 21699-21705 NN denotes kidney
T10358 21695-21698 DT denotes the
T10357 21692-21694 IN denotes of
T10356 21678-21686 JJ denotes ureteric
T10355 21687-21691 NN denotes tree
T10354 21674-21677 DT denotes the
T10098 20513-20519 NN denotes Figure
T10097 20524-20529 JJ denotes right
T10096 20512-20513 -LRB- denotes (
T10095 20510-20511 SYM denotes -
T10094 20509-20510 HYPH denotes /
T10093 20508-20509 SYM denotes -
T10092 20503-20508 NN denotes Pygo2
T10091 20502-20503 HYPH denotes /
T10090 20501-20502 SYM denotes -
T10089 20500-20501 HYPH denotes /
T10088 20499-20500 SYM denotes -
T10087 20494-20499 NN denotes Pygo1
T10086 20490-20493 CC denotes and
T10085 20488-20490 , denotes ,
T10084 20487-20488 -RRB- denotes )
T10083 20479-20481 , denotes ,
T10082 20477-20479 NN denotes 6O
T10081 20470-20476 NN denotes Figure
T10080 20481-20487 JJ denotes middle
T10079 20469-20470 -LRB- denotes (
T10078 20467-20468 SYM denotes -
T10077 20466-20467 HYPH denotes /
T10076 20465-20466 SYM denotes +
T10075 20460-20465 NN denotes Pygo2
T10074 20459-20460 HYPH denotes /
T10073 20458-20459 SYM denotes -
T10072 20457-20458 HYPH denotes /
T10071 20456-20457 SYM denotes -
T10070 20451-20456 NN denotes Pygo1
T10069 20449-20451 , denotes ,
T10068 20448-20449 -RRB- denotes )
T10067 20442-20444 , denotes ,
T10066 20440-20442 NN denotes 6O
T10065 20433-20439 NN denotes Figure
T10064 20444-20448 JJ denotes left
T10063 20432-20433 -LRB- denotes (
T10062 20430-20431 SYM denotes -
T10061 20429-20430 HYPH denotes /
T10060 20428-20429 SYM denotes +
T10059 20423-20428 NN denotes Pygo2
T10058 20422-20423 HYPH denotes /
T10057 20421-20422 SYM denotes +
T10056 20420-20421 HYPH denotes /
T10055 20419-20420 SYM denotes +
T10054 20537-20544 NNS denotes kidneys
T10053 20414-20419 NN denotes Pygo1
T10052 20411-20413 IN denotes of
T10051 20545-20554 VBD denotes suggested
T10050 20395-20399 NN denotes side
T10049 20392-20394 IN denotes by
T10048 20400-20410 NN denotes comparison
T10047 20387-20391 NN denotes Side
T10046 20386-20661 sentence denotes Side by side comparison of Pygo1+/+/Pygo2+/- (Figure 6O, left), Pygo1-/-/Pygo2+/- (Figure 6O, middle), and Pygo1-/-/Pygo2-/- (Figure 6O, right) E18.5 kidneys suggested a significant role for the Pygo2 gene in canonical Wnt signaling in the ureteric tree and its derivatives.
T10045 20385-20386 . denotes .
T10044 20384-20385 -RRB- denotes )
T10043 20375-20381 NN denotes Figure
T10042 20382-20384 NN denotes 6N
T10041 20374-20375 -LRB- denotes (
T10040 20362-20373 NNS denotes littermates
T10039 20354-20361 NN denotes control
T10038 20349-20353 IN denotes with
T10037 20340-20348 VBN denotes compared
T10036 20328-20332 JJ denotes null
T10035 20322-20327 NN denotes Pygo2
T10034 20333-20339 NN denotes kidney
T10033 20318-20321 DT denotes the
T10032 20315-20317 IN denotes of
T10031 20308-20314 NN denotes pelvis
T10030 20302-20307 JJ denotes renal
T10029 20298-20301 CC denotes and
T10028 20281-20291 VBG denotes collecting
T10027 20292-20297 NNS denotes ducts
T10026 20277-20280 DT denotes the
T10025 20274-20276 IN denotes in
T10024 20268-20273 NNS denotes cells
T10023 20259-20267 VBG denotes staining
T10022 20254-20255 HYPH denotes -
T10021 20255-20258 NN denotes gal
T10020 20253-20254 NN denotes X
T10019 20250-20252 IN denotes of
T10018 20233-20244 JJ denotes significant
T10017 20245-20249 NN denotes loss
T10016 20231-20232 DT denotes a
T10015 20222-20230 VBD denotes revealed
T10014 20212-20221 NN denotes Bisection
T10013 20211-20386 sentence denotes Bisection revealed a significant loss of X-gal staining cells in the collecting ducts and renal pelvis of the Pygo2 null kidney compared with control littermates (Figure 6N).
T10012 20210-20211 . denotes .
T10011 20209-20210 -RRB- denotes )
T10010 20202-20204 , denotes ,
T10009 20200-20202 NN denotes 6M
T10008 20193-20199 NN denotes Figure
T10007 20204-20209 JJ denotes right
T10006 20192-20193 -LRB- denotes (
T10005 20183-20184 SYM denotes -
T10004 20182-20183 HYPH denotes /
T10003 20181-20182 SYM denotes -
T10002 20176-20181 NN denotes Pygo2
T10001 20175-20176 HYPH denotes /
T10000 20174-20175 SYM denotes -
T9999 20173-20174 HYPH denotes /
T9998 20172-20173 SYM denotes +
T9997 20167-20172 NN denotes Pygo1
T9996 20185-20191 NN denotes kidney
T9995 20165-20166 DT denotes a
T9994 20162-20164 IN denotes of
T9993 20155-20161 NN denotes cortex
T9992 20151-20154 DT denotes the
T9991 20148-20150 IN denotes in
T9990 20141-20147 JJ denotes absent
T9989 20130-20140 RB denotes completely
T9988 20126-20129 VBD denotes was
T9987 20122-20125 CC denotes but
T9986 20120-20122 , denotes ,
T9985 20119-20120 -RRB- denotes )
T9984 20113-20115 , denotes ,
T9983 20111-20113 NN denotes 6M
T9982 20104-20110 NN denotes Figure
T9981 20115-20119 JJ denotes left
T9980 20103-20104 -LRB- denotes (
T9979 20094-20095 SYM denotes -
T9978 20093-20094 HYPH denotes /
T9977 20092-20093 SYM denotes +
T9976 20087-20092 NN denotes Pygo2
T9975 20086-20087 HYPH denotes /
T9974 20085-20086 SYM denotes -
T9973 20084-20085 HYPH denotes /
T9972 20083-20084 SYM denotes +
T9971 20078-20083 NN denotes Pygo1
T9970 20096-20102 NN denotes kidney
T9969 20076-20077 DT denotes a
T9968 20073-20075 IN denotes of
T9967 20055-20063 JJ denotes ureteric
T9966 20064-20072 NNS denotes branches
T9965 20051-20054 DT denotes the
T9964 20048-20050 IN denotes in
T9963 20039-20042 VBD denotes was
T9962 20043-20047 VBN denotes seen
T9961 20025-20026 HYPH denotes -
T9960 20026-20029 NN denotes gal
T9959 20024-20025 NN denotes X
T9958 20030-20038 NN denotes staining
T9957 20015-20023 JJ denotes Cortical
T9956 20014-20211 sentence denotes Cortical X-gal staining was seen in the ureteric branches of a Pygo1+/-/Pygo2+/- kidney (Figure 6M, left), but was completely absent in the cortex of a Pygo1+/-/Pygo2-/- kidney (Figure 6M, right).
T9955 20013-20014 . denotes .
T9954 20012-20013 -RRB- denotes )
T9953 20011-20012 NN denotes O
T9952 20010-20011 SYM denotes –
T9951 20001-20007 NN denotes Figure
T9950 20008-20010 NN denotes 6M
T9949 20000-20001 -LRB- denotes (
T9948 19982-19992 VBG denotes developing
T9947 19993-19999 NN denotes kidney
T9946 19978-19981 DT denotes the
T9945 19975-19977 IN denotes of
T9944 19968-19974 NN denotes pelvis
T9943 19962-19967 JJ denotes renal
T9942 19958-19961 CC denotes and
T9941 19940-19948 JJ denotes ureteric
T9940 19931-19939 JJ denotes cortical
T9939 19949-19957 NNS denotes branches
T9938 19927-19930 DT denotes the
T9937 19924-19926 IN denotes in
T9936 19910-19913 NN denotes Wnt
T9935 19914-19923 NN denotes signaling
T9934 19900-19909 JJ denotes canonical
T9933 19897-19899 IN denotes in
T9932 19876-19887 JJ denotes significant
T9931 19888-19896 NN denotes decrease
T9930 19874-19875 DT denotes a
T9929 19858-19862 RB denotes also
T9928 19856-19858 , denotes ,
T9927 19851-19856 NN denotes E18.5
T9926 19849-19851 , denotes ,
T9925 19830-19843 JJ denotes developmental
T9924 19824-19829 RB denotes later
T9923 19844-19849 NN denotes stage
T9922 19822-19823 DT denotes a
T9921 19819-19821 IN denotes at
T9856 19586-19592 VBD denotes showed
T9855 19578-19585 NNS denotes mutants
T9854 19566-19567 HYPH denotes -
T9853 19567-19577 JJ denotes homozygous
T9852 19560-19566 JJ denotes double
T9851 19556-19559 CC denotes and
T9850 19554-19556 , denotes ,
T9849 19553-19554 -RRB- denotes )
T9848 19544-19547 RB denotes not
T9847 19539-19543 NNS denotes data
T9846 19548-19553 VBN denotes shown
T9845 19538-19539 -LRB- denotes (
T9844 19527-19537 NN denotes expression
T9843 19518-19526 NN denotes reporter
T9842 19515-19517 IN denotes of
T9841 19498-19509 JJ denotes significant
T9840 19510-19514 NN denotes loss
T9839 19496-19497 DT denotes a
T9838 19486-19491 EX denotes there
T9837 19484-19486 , denotes ,
T9836 19478-19479 SYM denotes -
T9835 19477-19478 HYPH denotes /
T9834 19476-19477 SYM denotes -
T9833 19480-19484 NNS denotes mice
T9832 19471-19476 NN denotes Pygo2
T9831 19492-19495 VBD denotes was
T9830 19468-19470 IN denotes In
T9829 19467-19772 sentence denotes In Pygo2-/- mice, there was a significant loss of reporter expression (data not shown), and double-homozygous mutants showed loss of X-gal staining in the paramesonephric ducts (Figure 6K), whereas Pygo1-/-/Pygo2+/- and Pygo1+/-/Pygo2+/- mice showed normal levels of BAT-gal expression (Figure 6G, H, J).
T9828 19466-19467 . denotes .
T9827 19459-19460 -RRB- denotes )
T9826 19450-19459 JJ denotes Mullerian
T9825 19449-19450 -LRB- denotes (
T9824 19433-19448 JJ denotes paramesonephric
T9823 19461-19466 NNS denotes ducts
T9822 19429-19432 DT denotes the
T9821 19426-19428 IN denotes in
T9820 19415-19425 NN denotes expression
T9819 19406-19414 NN denotes reporter
T10137 20736-20738 IN denotes in
T9818 19401-19402 HYPH denotes -
T9817 19402-19405 NN denotes gal
T9816 19398-19401 NN denotes BAT
T9815 19394-19397 IN denotes for
T9814 19380-19384 RB denotes also
T9813 19375-19379 VBD denotes were
T9812 19385-19393 VBN denotes required
T9811 19363-19368 NN denotes Pygo2
T9810 19359-19362 CC denotes and
T9809 19353-19358 NN denotes Pygo1
T9808 19369-19374 NNS denotes genes
T9807 19349-19352 DT denotes The
T9806 19348-19467 sentence denotes The Pygo1 and Pygo2 genes were also required for BAT-gal reporter expression in the paramesonephric (Mullerian) ducts.
T9805 19347-19348 . denotes .
T9804 19346-19347 -RRB- denotes )
T9803 19343-19345 , denotes ,
T9802 19341-19343 NN denotes 6F
T9801 19334-19340 NN denotes Figure
T9800 19345-19346 NN denotes L
T9799 19333-19334 -LRB- denotes (
T9798 19327-19332 RB denotes alone
T9797 19321-19326 NN denotes Pygo2
T9796 19318-19320 IN denotes of
T9795 19313-19317 NN denotes loss
T9794 19308-19312 IN denotes than
T9793 19297-19307 NN denotes expression
T9792 19292-19293 HYPH denotes -
T9791 19293-19296 NN denotes gal
T9790 19289-19292 NN denotes BAT
T9789 19286-19288 IN denotes of
T9788 19267-19275 JJ denotes dramatic
T9787 19262-19266 RBR denotes more
T9786 19276-19285 NN denotes reduction
T9785 19260-19261 DT denotes a
T9784 19243-19248 NN denotes Pygo2
T9783 19239-19242 CC denotes and
T9782 19233-19238 NN denotes Pygo1
T9781 19229-19232 DT denotes the
T9780 19249-19254 NNS denotes genes
T9779 19224-19228 CC denotes both
T9778 19221-19223 IN denotes of
T9777 19255-19259 VBD denotes gave
T9776 19212-19220 NN denotes mutation
T9775 19201-19211 JJ denotes Homozygous
T9774 19200-19348 sentence denotes Homozygous mutation of both the Pygo1 and Pygo2 genes gave a more dramatic reduction of BAT-gal expression than loss of Pygo2 alone (Figure 6F, L).
T9773 19199-19200 . denotes .
T9772 19198-19199 -RRB- denotes )
T9771 19197-19198 NN denotes H
T9770 19196-19197 SYM denotes –
T9769 19187-19193 NN denotes Figure
T9768 19194-19196 NN denotes 6G
T9767 19186-19187 -LRB- denotes (
T9766 19175-19185 NN denotes expression
T9765 19166-19174 NN denotes reporter
T9764 19163-19165 IN denotes on
T9763 19150-19155 JJ denotes small
T9762 19156-19162 NN denotes effect
T9761 19148-19149 DT denotes a
T9760 19142-19144 , denotes ,
T9759 19135-19142 RB denotes however
T9758 19133-19135 , denotes ,
T9757 19128-19133 RB denotes alone
T9756 19117-19122 NN denotes Pygo1
T9755 19123-19127 NN denotes gene
T9754 19113-19116 DT denotes the
T9753 19110-19112 IN denotes of
T9752 19144-19147 VBD denotes had
T9751 19105-19109 NN denotes loss
T9750 19094-19104 JJ denotes Homozygous
T9749 19093-19200 sentence denotes Homozygous loss of the Pygo1 gene alone, however, had a small effect on reporter expression (Figure 6G–H).
T9748 19092-19093 . denotes .
T9747 19079-19082 NN denotes Wnt
T9746 19083-19092 NN denotes signaling
T9745 19069-19078 JJ denotes canonical
T9744 19066-19068 IN denotes of
T9743 19049-19060 JJ denotes significant
T9742 19061-19065 NN denotes loss
T9741 19047-19048 DT denotes a
T9740 19036-19046 VBG denotes suggesting
T9739 19034-19036 , denotes ,
T9738 19033-19034 -RRB- denotes )
T9737 19024-19030 NN denotes Figure
T9736 19031-19033 NN denotes 6F
T9735 19023-19024 -LRB- denotes (
T9734 19003-19011 NN denotes reporter
T9733 19012-19022 NN denotes expression
T9732 18998-19002 JJ denotes weak
T9731 18993-18997 RB denotes very
T9730 18972-18977 NN denotes E13.5
T9729 18970-18971 SYM denotes -
T9728 18969-18970 HYPH denotes /
T9727 18968-18969 SYM denotes -
T9726 18963-18968 NN denotes Pygo2
T9725 18962-18963 HYPH denotes /
T9724 18961-18962 SYM denotes -
T9723 18960-18961 HYPH denotes /
T9722 18959-18960 SYM denotes +
T9721 18978-18985 NNS denotes kidneys
T9720 18954-18959 NN denotes Pygo1
T9719 18952-18954 , denotes ,
T9718 18944-18952 NN denotes contrast
T9717 18986-18992 VBD denotes showed
T9716 18941-18943 IN denotes In
T9715 18940-19093 sentence denotes In contrast, Pygo1+/-/Pygo2-/- E13.5 kidneys showed very weak reporter expression (Figure 6F), suggesting a significant loss of canonical Wnt signaling.
T9714 18939-18940 . denotes .
T9713 18938-18939 -RRB- denotes )
T9712 18929-18935 NN denotes Figure
T9711 18936-18938 NN denotes 6E
T9710 18928-18929 -LRB- denotes (
T9709 18914-18922 JJ denotes ureteric
T9708 18923-18927 NN denotes tree
T9707 18910-18913 DT denotes the
T9706 18907-18909 IN denotes in
T9705 18893-18894 HYPH denotes -
T9704 18894-18897 NN denotes gal
T9703 18892-18893 NN denotes X
T9702 18898-18906 NN denotes staining
T9701 18885-18891 JJ denotes strong
T9700 18867-18872 NN denotes Pygo2
T9699 18861-18862 HYPH denotes -
T9698 18862-18866 NN denotes type
T9697 18857-18861 JJ denotes wild
T9696 18873-18877 NN denotes gene
T9695 18847-18852 RBS denotes least
T9694 18853-18856 CD denotes one
T9693 18844-18846 RB denotes at
T9692 18839-18843 IN denotes with
T9691 18821-18831 JJ denotes transgenic
T9690 18816-18817 HYPH denotes -
T9689 18817-18820 NN denotes gal
T9688 18813-18816 NN denotes BAT
T9687 18832-18838 NN denotes kidney
T9686 18811-18812 DT denotes a
T9685 18878-18884 VBD denotes showed
T9684 18803-18810 IN denotes whereas
T9683 18801-18803 , denotes ,
T9682 18800-18801 -RRB- denotes )
T9681 18791-18797 NN denotes Figure
T9680 18798-18800 NN denotes 6D
T9679 18790-18791 -LRB- denotes (
T9678 18776-18777 HYPH denotes -
T9677 18777-18780 NN denotes gal
T9676 18775-18776 NN denotes X
T9675 18781-18789 NN denotes staining
T9674 18764-18774 NN denotes background
T9673 18756-18763 JJ denotes minimal
T9672 18747-18749 , denotes ,
T9671 18733-18734 HYPH denotes -
T9670 18734-18737 NN denotes gal
T9669 18730-18733 NN denotes BAT
T9668 18738-18747 NN denotes transgene
T9667 18726-18729 DT denotes the
T9666 18718-18725 IN denotes without
T9665 18716-18718 , denotes ,
T9664 18749-18755 VBD denotes showed
T9663 18702-18709 NN denotes control
T9662 18693-18701 JJ denotes negative
T9661 18710-18716 NN denotes kidney
T9660 18691-18692 DT denotes A
T9659 18690-18940 sentence denotes A negative control kidney, without the BAT-gal transgene, showed minimal background X-gal staining (Figure 6D), whereas a BAT-gal transgenic kidney with at least one wild-type Pygo2 gene showed strong X-gal staining in the ureteric tree (Figure 6E).
T9658 18689-18690 . denotes .
T9657 18679-18689 NN denotes expression
T9656 18674-18675 HYPH denotes -
T9655 18675-18678 NN denotes gal
T9654 18671-18674 NN denotes BAT
T9653 18668-18670 IN denotes by
T9652 18659-18667 VBN denotes measured
T9651 18656-18658 IN denotes as
T9650 18654-18656 , denotes ,
T9649 18641-18649 JJ denotes ureteric
T9648 18650-18654 NN denotes tree
T9647 18637-18640 DT denotes the
T9646 18634-18636 IN denotes in
T9645 18620-18623 NN denotes Wnt
T9644 18624-18633 NN denotes signaling
T9643 18610-18619 JJ denotes canonical
T9920 19806-19810 NN denotes Pygo
T9919 19811-19818 NNS denotes mutants
T9918 19802-19805 DT denotes the
T9917 19799-19801 IN denotes of
T9916 19863-19873 VBD denotes identified
T9915 19790-19798 NN denotes analysis
T9914 19781-19789 NN denotes reporter
T9913 19776-19777 HYPH denotes -
T9912 19777-19780 NN denotes gal
T9911 19773-19776 NN denotes BAT
T9910 19772-20014 sentence denotes BAT-gal reporter analysis of the Pygo mutants at a later developmental stage, E18.5, also identified a significant decrease in canonical Wnt signaling in the cortical ureteric branches and renal pelvis of the developing kidney (Figure 6M–O).
T9909 19771-19772 . denotes .
T9908 19770-19771 -RRB- denotes )
T9907 19767-19769 , denotes ,
T9906 19766-19767 NN denotes H
T9905 19764-19766 , denotes ,
T9904 19762-19764 NN denotes 6G
T9903 19755-19761 NN denotes Figure
T9902 19769-19770 NN denotes J
T9901 19754-19755 -LRB- denotes (
T9900 19743-19753 NN denotes expression
T9899 19738-19739 HYPH denotes -
T9898 19739-19742 NN denotes gal
T9897 19735-19738 NN denotes BAT
T9896 19732-19734 IN denotes of
T9895 19725-19731 NNS denotes levels
T9894 19718-19724 JJ denotes normal
T9893 19704-19705 SYM denotes -
T9892 19703-19704 HYPH denotes /
T9891 19702-19703 SYM denotes +
T9890 19697-19702 NN denotes Pygo2
T9889 19696-19697 HYPH denotes /
T9888 19695-19696 SYM denotes -
T9887 19694-19695 HYPH denotes /
T9886 19693-19694 SYM denotes +
T9885 19688-19693 NN denotes Pygo1
T9884 19684-19687 CC denotes and
T9883 19682-19683 SYM denotes -
T9882 19681-19682 HYPH denotes /
T9881 19680-19681 SYM denotes +
T9880 19675-19680 NN denotes Pygo2
T9879 19674-19675 HYPH denotes /
T9878 19673-19674 SYM denotes -
T9877 19672-19673 HYPH denotes /
T9876 19671-19672 SYM denotes -
T9875 19706-19710 NNS denotes mice
T9874 19666-19671 NN denotes Pygo1
T9873 19711-19717 VBD denotes showed
T9872 19658-19665 IN denotes whereas
T9871 19656-19658 , denotes ,
T9870 19655-19656 -RRB- denotes )
T9869 19646-19652 NN denotes Figure
T9868 19653-19655 NN denotes 6K
T9867 19645-19646 -LRB- denotes (
T9866 19623-19638 JJ denotes paramesonephric
T9865 19639-19644 NNS denotes ducts
T9864 19619-19622 DT denotes the
T9863 19616-19618 IN denotes in
T9862 19607-19615 NN denotes staining
T9861 19602-19603 HYPH denotes -
T9860 19603-19606 NN denotes gal
T9859 19601-19602 NN denotes X
T9858 19598-19600 IN denotes of
T9857 19593-19597 NN denotes loss
T9590 15997-15998 NN denotes C
T9589 15996-15997 SYM denotes –
T9588 15987-15993 NN denotes Figure
T9587 15994-15996 NN denotes 6A
T9586 15986-15987 -LRB- denotes (
T9585 15966-15974 NN denotes reporter
T9584 15961-15962 HYPH denotes -
T9583 15962-15965 NN denotes gal
T9582 15958-15961 NN denotes BAT
T9581 15951-15957 JJ denotes absent
T9580 15947-15950 RB denotes not
T9579 15943-15946 CC denotes but
T9578 15975-15985 NN denotes expression
T9577 15935-15942 VBN denotes reduced
T9576 15928-15934 VBD denotes showed
T9575 15922-15927 WDT denotes which
T9574 15920-15922 , denotes ,
T9573 15907-15910 NN denotes bud
T9572 15898-15906 JJ denotes ureteric
T9571 15911-15920 NN denotes outgrowth
T9570 15894-15897 DT denotes the
T9569 15891-15893 IN denotes to
T9568 15886-15890 NN denotes rise
T9567 15881-15885 VB denotes give
T9566 15877-15880 CC denotes and
T9565 15875-15877 , denotes ,
T9564 15868-15875 RB denotes however
T9563 15866-15868 , denotes ,
T9562 15858-15861 VBD denotes did
T9561 15845-15852 JJ denotes nephric
T9560 15853-15857 NN denotes duct
T9559 15841-15844 DT denotes the
T9558 15839-15841 , denotes ,
T9557 15832-15839 NNS denotes mutants
T9556 15826-15827 HYPH denotes -
T9555 15820-15826 JJ denotes double
T9554 15827-15831 JJ denotes null
T9553 15813-15814 HYPH denotes /
T9552 15814-15819 NN denotes Pygo2
T9551 15808-15813 NN denotes Pygo1
T9550 15862-15866 VB denotes form
T9549 15805-15807 IN denotes In
T9548 15804-16000 sentence denotes In Pygo1/Pygo2 double-null mutants, the nephric duct did form, however, and give rise to the ureteric bud outgrowth, which showed reduced but not absent BAT-gal reporter expression (Figure 6A–C).
T9547 15803-15804 . denotes .
T9546 15802-15803 -RRB- denotes )
T9545 15801-15802 NN denotes C
T9544 15800-15801 SYM denotes –
T9543 15791-15797 NN denotes Figure
T9542 15798-15800 NN denotes 6A
T9541 15790-15791 -LRB- denotes (
T9540 15779-15789 NN denotes expression
T9539 15772-15778 JJ denotes strong
T9538 15753-15764 NNS denotes littermates
T9537 15745-15752 NN denotes control
T9536 15765-15771 VBD denotes showed
T9535 15739-15744 IN denotes while
T9534 15737-15739 , denotes ,
T9533 15725-15732 JJ denotes nephric
T9532 15733-15737 NN denotes duct
T9531 15721-15724 DT denotes the
T9530 15718-15720 IN denotes in
T9529 15707-15717 NN denotes expression
T9528 15698-15706 NN denotes reporter
T9527 15695-15697 IN denotes of
T9526 15687-15694 NN denotes absence
T9525 15684-15686 DT denotes an
T9524 15677-15683 VBD denotes showed
T9523 15663-15668 NN denotes E10.5
T9522 15657-15658 HYPH denotes -
T9521 15651-15657 JJ denotes double
T9520 15658-15662 JJ denotes null
T9519 15644-15645 HYPH denotes /
T9518 15645-15650 NN denotes Pygo2
T9517 15639-15644 NN denotes Pygo1
T9516 15635-15638 CC denotes and
T9515 15669-15676 NNS denotes embryos
T9514 15624-15629 NN denotes Pygo2
T9513 15630-15634 JJ denotes null
T9512 15619-15623 CC denotes Both
T9511 15618-15804 sentence denotes Both Pygo2 null and Pygo1/Pygo2 double-null E10.5 embryos showed an absence of reporter expression in the nephric duct, while control littermates showed strong expression (Figure 6A–C).
T9510 15617-15618 . denotes .
T9509 15605-15612 JJ denotes nephric
T9508 15613-15617 NN denotes duct
T9507 15601-15604 DT denotes the
T9506 15598-15600 IN denotes in
T9505 15584-15587 NN denotes Wnt
T9504 15588-15597 NN denotes signaling
T9503 15574-15583 JJ denotes canonical
T9502 15570-15573 IN denotes for
T9501 15558-15560 VBZ denotes is
T9500 15547-15552 NN denotes Pygo2
T9499 15553-15557 NN denotes gene
T9498 15543-15546 DT denotes the
T9497 15561-15569 VBN denotes required
T9496 15538-15542 IN denotes that
T9495 15528-15537 VBD denotes suggested
T9494 15520-15527 NNS denotes results
T9493 15516-15519 DT denotes The
T9492 15515-15618 sentence denotes The results suggested that the Pygo2 gene is required for canonical Wnt signaling in the nephric duct.
T9491 15514-15515 . denotes .
T9490 15507-15514 NNS denotes mutants
T9489 15502-15506 NN denotes Pygo
T9488 15499-15501 IN denotes of
T9487 15481-15491 JJ denotes urogenital
T9486 15470-15480 VBG denotes developing
T9485 15492-15498 NN denotes system
T9335 13705-13714 NN denotes transgene
T9334 13700-13701 HYPH denotes -
T9333 13701-13704 NN denotes gal
T9332 13697-13700 NN denotes BAT
T9331 13715-13723 NN denotes reporter
T9330 13693-13696 DT denotes The
T9329 13692-13820 sentence denotes The BAT-gal transgene reporter of canonical Wnt signaling [21] was used to examine changes in Wnt signaling in the mutant mice.
T9328 13688-13692 NNS denotes mice
T9327 13681-13687 NN denotes mutant
T9326 13674-13675 HYPH denotes /
T9325 13675-13680 NN denotes Pygo2
T9324 13669-13674 NN denotes Pygo1
T9323 13666-13668 IN denotes in
T9322 13652-13655 NN denotes Wnt
T9321 13642-13651 JJ denotes canonical
T9320 13656-13665 NN denotes signaling
T9319 13634-13641 VBN denotes Reduced
T9409 14065-14067 , denotes ,
T9408 14056-14065 NN denotes reduction
T9407 14049-14055 JJ denotes strong
T9406 14039-14041 , denotes ,
T9405 14032-14039 NN denotes example
T9404 14028-14031 IN denotes for
T9403 14026-14028 , denotes ,
T9402 14041-14048 VBG denotes showing
T9401 14019-14026 NNS denotes somites
T9400 14015-14018 DT denotes the
T9399 14010-14014 IN denotes with
T9398 14008-14010 , denotes ,
T9397 13999-14008 NN denotes reduction
T9396 13996-13998 IN denotes of
T9395 13989-13995 NN denotes degree
T9394 13985-13988 DT denotes the
T9393 13982-13984 IN denotes in
T9392 13970-13981 NN denotes variability
T9391 13960-13961 HYPH denotes -
T9390 13961-13969 JJ denotes specific
T9389 13954-13960 NN denotes tissue
T9388 13952-13954 , denotes ,
T9387 13945-13952 RB denotes however
T9386 13943-13945 , denotes ,
T9385 13940-13943 VBD denotes was
T9384 13934-13939 EX denotes There
T9383 13933-14132 sentence denotes There was, however, tissue-specific variability in the degree of reduction, with the somites, for example, showing strong reduction, while the mutant telencephalon still showed robust Wnt signaling.
T9382 13932-13933 . denotes .
T9381 13931-13932 -RRB- denotes )
T9380 13930-13931 CD denotes 5
T9379 13923-13929 NN denotes Figure
T9378 13922-13923 -LRB- denotes (
T9377 13908-13911 NN denotes Wnt
T9376 13912-13921 NN denotes signaling
T9375 13898-13907 JJ denotes canonical
T9374 13895-13897 IN denotes in
T9373 13886-13894 NN denotes decrease
T9372 13884-13885 DT denotes a
T9371 13877-13883 VBD denotes showed
T9370 13863-13868 NN denotes E10.5
T9369 13869-13876 NNS denotes embryos
T9368 13857-13858 HYPH denotes -
T9367 13851-13857 JJ denotes double
T9366 13844-13845 HYPH denotes /
T9365 13845-13850 NN denotes Pygo2
T9364 13839-13844 NN denotes Pygo1
T9363 13835-13838 CC denotes and
T9362 13833-13834 SYM denotes -
T9361 13832-13833 HYPH denotes /
T9360 13831-13832 SYM denotes -
T9359 13858-13862 JJ denotes null
T9358 13826-13831 NN denotes Pygo2
T9357 13821-13825 CC denotes Both
T9356 13820-13933 sentence denotes Both Pygo2-/- and Pygo1/Pygo2 double-null E10.5 embryos showed a decrease in canonical Wnt signaling (Figure 5).
T9355 13819-13820 . denotes .
T9354 13808-13814 NN denotes mutant
T9353 13815-13819 NNS denotes mice
T9352 13804-13807 DT denotes the
T9351 13801-13803 IN denotes in
T9350 13791-13800 NN denotes signaling
T9349 13787-13790 NN denotes Wnt
T9348 13784-13786 IN denotes in
T9347 13776-13783 NNS denotes changes
T9346 13768-13775 VB denotes examine
T9345 13765-13767 TO denotes to
T9344 13756-13759 VBD denotes was
T9343 13754-13755 -RRB- denotes ]
T9342 13752-13754 CD denotes 21
T9341 13751-13752 -LRB- denotes [
T9340 13737-13740 NN denotes Wnt
T9339 13741-13750 NN denotes signaling
T9338 13727-13736 JJ denotes canonical
T9337 13724-13726 IN denotes of
T9336 13760-13764 VBN denotes used
T6354 12762-12765 DT denotes the
T6433 13129-13130 HYPH denotes -
T6432 13123-13129 JJ denotes double
T6431 13130-13140 JJ denotes homozygous
T6430 13116-13117 HYPH denotes /
T6429 13117-13122 NN denotes Pygo2
T6428 13111-13116 NN denotes Pygo1
T6427 13141-13148 NNS denotes mutants
T6426 13107-13110 DT denotes the
T6425 13104-13106 IN denotes in
T6424 13099-13103 NN denotes area
T6423 13091-13098 NN denotes surface
T6422 13087-13090 IN denotes per
T6421 13085-13086 -RRB- denotes )
T6420 13076-13077 HYPH denotes -
T6419 13077-13085 JJ denotes positive
T6418 13071-13076 NN denotes Wnt11
T6417 13070-13071 -LRB- denotes (
T6416 13065-13069 NNS denotes tips
T6415 13062-13064 IN denotes of
T6414 13047-13054 VBN denotes reduced
T6413 13055-13061 NN denotes number
T6412 13045-13046 DT denotes a
T6411 13037-13044 VBG denotes showing
T6410 13035-13037 , denotes ,
T6409 13017-13027 NN denotes microscopy
T6408 13008-13016 JJ denotes confocal
T6407 13028-13035 NNS denotes results
T6406 13004-13007 DT denotes the
T6405 12971-12984 NN denotes hybridization
T6404 12966-12970 FW denotes situ
T6403 12963-12965 FW denotes in
T6402 12985-12993 NNS denotes patterns
T6401 12957-12962 DT denotes these
T6400 12955-12957 , denotes ,
T6399 12947-12955 NN denotes addition
T6398 12994-13003 VBD denotes confirmed
T6397 12944-12946 IN denotes In
T6396 12943-13149 sentence denotes In addition, these in situ hybridization patterns confirmed the confocal microscopy results, showing a reduced number of tips (Wnt11-positive) per surface area in the Pygo1/Pygo2 double-homozygous mutants.
T6395 12942-12943 . denotes .
T6394 12941-12942 -RRB- denotes )
T6393 12940-12941 CD denotes 4
T6392 12933-12939 NN denotes Figure
T6391 12932-12933 -LRB- denotes (
T6390 12916-12917 HYPH denotes -
T6389 12910-12916 JJ denotes double
T6388 12917-12923 NN denotes mutant
T6387 12903-12904 HYPH denotes /
T6386 12904-12909 NN denotes Pygo2
T6385 12898-12903 NN denotes Pygo1
T6384 12894-12897 CC denotes and
T6383 12892-12893 SYM denotes +
T6382 12891-12892 HYPH denotes /
T6381 12890-12891 SYM denotes +
T6380 12924-12931 NNS denotes kidneys
T6379 12885-12890 NN denotes Pygo2
T6378 12882-12884 IN denotes in
T6377 12862-12872 NN denotes expression
T6376 12873-12881 NNS denotes patterns
T6375 12854-12861 JJ denotes similar
T6374 12847-12853 VBD denotes showed
T6373 12835-12840 CD denotes three
T6372 12841-12846 NNS denotes genes
T6371 12831-12834 DT denotes All
T6370 12830-12943 sentence denotes All three genes showed similar expression patterns in Pygo2+/+ and Pygo1/Pygo2 double-mutant kidneys (Figure 4).
T6369 12829-12830 . denotes .
T6368 12828-12829 -RRB- denotes ]
T6367 12827-12828 CD denotes 2
T6366 12826-12827 -LRB- denotes [
T6365 12813-12821 JJ denotes ureteric
T6364 12803-12812 NN denotes branching
T6363 12822-12825 NN denotes bud
T6362 12799-12802 DT denotes the
T6361 12796-12798 IN denotes of
T6360 12791-12795 NNS denotes tips
T6359 12787-12790 DT denotes the
T6358 12784-12786 IN denotes in
T6357 12777-12783 RB denotes weakly
T6356 12773-12776 CC denotes and
T6355 12766-12772 NNS denotes stalks
T6353 12759-12761 IN denotes in
T6352 12753-12758 NN denotes Wnt9b
T6351 12749-12752 CC denotes and
T6350 12747-12749 , denotes ,
T6349 12746-12747 -RRB- denotes ]
T6348 12745-12746 CD denotes 4
T6347 12744-12745 -LRB- denotes [
T6346 12739-12743 NNS denotes tips
T6345 12735-12738 DT denotes the
T6344 12732-12734 IN denotes in
T6343 12726-12731 NN denotes Wnt11
T6342 12724-12726 , denotes ,
T6341 12723-12724 -RRB- denotes ]
T6340 12721-12723 CD denotes 20
T6339 12720-12721 -LRB- denotes [
T6338 12713-12719 NNS denotes stalks
T6337 12709-12712 DT denotes the
T6336 12706-12708 IN denotes in
T6335 12693-12695 VBZ denotes is
T6334 12696-12705 VBN denotes expressed
T6333 12687-12692 NN denotes Wnt7b
T6332 12686-12830 sentence denotes Wnt7b is expressed in the stalks [20], Wnt11 in the tips [4], and Wnt9b in the stalks and weakly in the tips of the branching ureteric bud [2].
T6331 12685-12686 . denotes .
T6330 12678-12685 NNS denotes mutants
T6329 12673-12677 NN denotes Pygo
T6328 12670-12672 IN denotes in
T6327 12660-12663 NN denotes Wnt
T6326 12664-12669 NNS denotes genes
T6325 12654-12659 CD denotes three
T6324 12651-12653 IN denotes of
T6323 12640-12650 NN denotes expression
T6028 12491-12604 sentence denotes No significant difference in ureteric bud-tip density was seen between Pygo2+/- and Pygo2+/+ embryos (P = 0.33).
T6027 12490-12491 . denotes .
T6026 12489-12490 -RRB- denotes )
T6025 12488-12489 CD denotes 2
T6024 12482-12487 NN denotes Table
T6023 12481-12482 -LRB- denotes (
T6022 12475-12480 NN denotes Pygo2
T6021 12472-12474 IN denotes of
T6020 12461-12462 HYPH denotes -
T6019 12462-12466 NN denotes type
T6018 12457-12461 JJ denotes wild
T6017 12467-12471 NN denotes copy
T6016 12447-12452 RBS denotes least
T6015 12453-12456 CD denotes one
T6014 12444-12446 RB denotes at
T6013 12439-12443 IN denotes with
T6012 12427-12438 NNS denotes littermates
T6011 12422-12426 IN denotes with
T6010 12413-12421 VBN denotes compared
T6009 12408-12412 NN denotes area
T6008 12404-12407 IN denotes per
T5812 10274-10275 sentence denotes
T5811 10273-10274 . denotes .
T5810 10272-10273 -RRB- denotes ]
T5809 10270-10272 CD denotes 19
T5808 10269-10270 -LRB- denotes [
T5807 10258-10268 NNS denotes structures
T5806 10249-10250 HYPH denotes -
T5805 10250-10257 VBN denotes derived
T5804 10246-10249 NN denotes bud
T5803 10237-10245 JJ denotes ureteric
T5802 10219-10230 RB denotes selectively
T5801 10231-10236 VB denotes stain
T5800 10216-10218 TO denotes to
T5799 10207-10210 VBD denotes was
T5798 10205-10206 -RRB- denotes ]
T5797 10203-10205 CD denotes 16
T5796 10202-10203 -LRB- denotes [
T5795 10211-10215 VBN denotes used
T5794 10193-10194 -RRB- denotes )
T5793 10190-10193 NN denotes DBA
T5792 10189-10190 -LRB- denotes (
T5791 10195-10201 NN denotes lectin
T5790 10180-10188 NN denotes biflorus
T5789 10171-10179 NN denotes Dolichos
T5788 10170-10274 sentence denotes Dolichos biflorus (DBA) lectin [16] was used to selectively stain ureteric bud-derived structures [19].
T5787 10169-10170 . denotes .
T5786 10168-10169 -RRB- denotes ]
T5785 10166-10168 CD denotes 18
T5784 10165-10166 -LRB- denotes [
T5783 10147-10157 VBG denotes developing
T5782 10158-10164 NN denotes kidney
T5781 10143-10146 DT denotes the
T5780 10140-10142 IN denotes of
T5779 10131-10139 NNS denotes nephrons
T5778 10123-10130 JJ denotes nascent
T5777 10119-10122 CC denotes and
T5776 10106-10114 JJ denotes ureteric
T5775 10096-10105 VBG denotes branching
T5774 10115-10118 NN denotes bud
T5773 10092-10095 DT denotes the
T5772 10082-10091 VBG denotes including
T5771 10080-10082 , denotes ,
T5770 10070-10080 NNS denotes structures
T5769 10059-10069 JJ denotes epithelial
T5768 10050-10058 VB denotes identify
T5767 10047-10049 TO denotes to
T5766 10037-10041 VBD denotes were
T5765 10035-10037 , denotes ,
T5764 10034-10035 -RRB- denotes )
T5763 10030-10034 NN denotes blue
T5762 10029-10030 -LRB- denotes (
T5761 10019-10020 HYPH denotes -
T5760 10020-10028 NN denotes cadherin
T5759 10018-10019 NN denotes E
T5758 10015-10017 IN denotes as
T5757 10009-10014 VBN denotes known
T5756 10004-10008 RB denotes also
T5755 10002-10004 , denotes ,
T5754 9998-10002 NN denotes Cdh1
T5753 9995-9997 IN denotes to
T5752 10042-10046 VBN denotes used
T5751 9984-9994 NNS denotes Antibodies
T5750 9983-10170 sentence denotes Antibodies to Cdh1, also known as E-cadherin (blue), were used to identify epithelial structures, including the branching ureteric bud and nascent nephrons of the developing kidney [18].
T5749 9982-9983 . denotes .
T5748 9976-9982 NN denotes anlage
T5747 9965-9975 JJ denotes glomerular
T5746 9961-9964 CC denotes and
T5745 9952-9960 NNS denotes vesicles
T5744 9946-9951 JJ denotes renal
T5743 9934-9938 RB denotes also
T5742 9939-9945 VBZ denotes stains
T5741 9925-9933 NN denotes antibody
T5740 9921-9924 NN denotes WT1
T5739 9920-9983 sentence denotes WT1 antibody also stains renal vesicles and glomerular anlage.
T5738 9919-9920 . denotes .
T5737 9918-9919 -RRB- denotes ]
T5736 9916-9918 CD denotes 17
T5735 9915-9916 -LRB- denotes [
T5734 9906-9909 NN denotes bud
T5733 9897-9905 JJ denotes ureteric
T5732 9910-9914 NNS denotes tips
T5731 9893-9896 DT denotes the
T5719 9812-9815 CC denotes and
T5718 9810-9811 -RRB- denotes )
T5717 9807-9810 NN denotes red
T5716 9806-9807 -LRB- denotes (
T5715 9829-9839 NNS denotes antibodies
T5714 9802-9805 NN denotes Wt1
T5713 9801-9920 sentence denotes Wt1 (red) and Cited1 (red) antibodies both stain the capping metanephric mesenchyme around the ureteric bud tips [17].
T5712 9800-9801 . denotes .
T5711 9799-9800 -RRB- denotes )
T5710 9798-9799 CD denotes 3
T5709 9791-9797 NN denotes Figure
T5708 9790-9791 -LRB- denotes (
T5707 9780-9789 RB denotes precisely
T5706 9775-9779 RBR denotes more
T5705 9762-9766 JJ denotes null
T5704 9755-9756 HYPH denotes /
T5703 9756-9761 NN denotes Pygo2
T5702 9750-9755 NN denotes Pygo1
T5701 9767-9774 NNS denotes kidneys
T5700 9744-9749 NN denotes E18.5
T5699 9741-9743 IN denotes in
T5698 9729-9740 NN denotes development
T5697 9723-9728 JJ denotes renal
T5696 9710-9722 VB denotes characterize
T5695 9707-9709 TO denotes to
T5694 9687-9696 RB denotes therefore
T5693 9683-9686 VBD denotes was
T5692 9697-9706 VBN denotes performed
T5691 9674-9682 NN denotes analysis
T5690 9665-9673 JJ denotes Confocal
T5689 9664-9801 sentence denotes Confocal analysis was therefore performed to characterize renal development in E18.5 Pygo1/Pygo2 null kidneys more precisely (Figure 3).
T5688 9663-9664 . denotes .
T5687 9662-9663 -RRB- denotes )
T5686 9653-9656 RB denotes not
T5685 9648-9652 NNS denotes data
T5684 9657-9662 VBN denotes shown
T5683 9647-9648 -LRB- denotes (
T5682 9633-9646 NN denotes nephrogenesis
T5681 9630-9632 IN denotes in
T5680 9616-9629 NNS denotes abnormalities
T5679 9612-9615 DT denotes any
T5678 9601-9604 RB denotes not
T5677 9597-9600 VBD denotes did
T5676 9582-9588 NN denotes mutant
T5675 9576-9577 HYPH denotes -
T5674 9570-9576 JJ denotes double
T5673 9577-9581 JJ denotes null
T5672 9563-9564 HYPH denotes /
T5671 9564-9569 NN denotes Pygo2
T5670 9558-9563 NN denotes Pygo1
T5669 9554-9557 CC denotes and
T5668 9589-9596 NNS denotes kidneys
T5667 9549-9553 JJ denotes null
T5666 9543-9548 NN denotes Pygo2
T5665 9540-9542 IN denotes of
T5664 9605-9611 VB denotes reveal
T5663 9528-9539 NN denotes examination
T5662 9515-9527 JJ denotes Histological
T5661 9514-9664 sentence denotes Histological examination of Pygo2 null and Pygo1/Pygo2 double-null mutant kidneys did not reveal any abnormalities in nephrogenesis (data not shown).
T5660 9507-9514 NNS denotes kidneys
T5659 9500-9506 NN denotes mutant
T5658 9493-9494 HYPH denotes /
T5657 9494-9499 NN denotes Pygo2
T5656 9488-9493 NN denotes Pygo1
T5655 9485-9487 IN denotes of
T5654 9476-9484 NN denotes analysis
T5653 9467-9475 JJ denotes Confocal
T6007 12399-12403 NNS denotes tips
T6006 12395-12398 NN denotes bud
T6005 12386-12394 JJ denotes ureteric
T6004 12383-12385 IN denotes of
T6003 12376-12382 NN denotes number
T6002 12372-12375 DT denotes the
T6001 12369-12371 IN denotes in
T6000 12367-12368 NN denotes %
T5999 12365-12367 CD denotes 25
T5998 12351-12364 RB denotes approximately
T5997 12348-12350 IN denotes of
T5996 12339-12347 NN denotes decrease
T5995 12337-12338 DT denotes a
T5994 12328-12332 RB denotes also
T5993 12313-12319 NN denotes mutant
T5992 12301-12302 HYPH denotes -
T5991 12295-12301 JJ denotes double
T5990 12302-12312 JJ denotes homozygous
T5989 12288-12289 HYPH denotes /
T5988 12289-12294 NN denotes Pygo2
T5987 12283-12288 NN denotes Pygo1
T5986 12320-12327 NNS denotes kidneys
T5985 12279-12282 DT denotes the
T5984 12277-12279 , denotes ,
T5983 12269-12277 NN denotes addition
T5982 12333-12336 VBD denotes had
T5981 12266-12268 IN denotes In
T5980 12265-12491 sentence denotes In addition, the Pygo1/Pygo2 double-homozygous mutant kidneys also had a decrease of approximately 25% in the number of ureteric bud tips per area compared with littermates with at least one wild-type copy of Pygo2 (Table 2).
T5979 12264-12265 . denotes .
T5978 12263-12264 -RRB- denotes )
T5977 12262-12263 CD denotes 3
T5976 12255-12261 NN denotes Figure
T5975 12254-12255 -LRB- denotes (
T5974 12241-12246 NN denotes Pygo2
T5973 12235-12236 HYPH denotes -
T5972 12236-12240 NN denotes type
T5971 12231-12235 JJ denotes wild
T5970 12247-12253 NN denotes allele
T5969 12221-12226 RBS denotes least
T5968 12227-12230 CD denotes one
T5967 12218-12220 RB denotes at
T5966 12213-12217 IN denotes with
T5965 12201-12212 NNS denotes littermates
T5964 12198-12200 IN denotes of
T5963 12192-12197 DT denotes those
T5962 12187-12191 IN denotes with
T5961 12178-12186 VBN denotes compared
T5960 12168-12177 JJ denotes misshaped
T5959 12164-12167 CC denotes and
T5958 12156-12163 JJ denotes dilated
T5957 12143-12150 NNS denotes kidneys
T5956 12138-12142 JJ denotes null
T5955 12131-12132 HYPH denotes /
T5954 12132-12137 NN denotes Pygo2
T5953 12126-12131 NN denotes Pygo1
T5952 12123-12125 IN denotes of
T5951 12121-12122 -RRB- denotes ]
T5940 12084-12085 NNS denotes s
T5939 12084-12085 sentence denotes s
T5938 12082-12083 IN denotes o
T5937 12080-12081 JJ denotes l
T5936 12079-12080 CC denotes a
T5935 12081-12082 NNS denotes s
T5934 11641-11649 NN denotes analysis
T5933 11632-11640 JJ denotes Confocal
T5932 11632-12084 sentence denotes Confocal analysis of Pygo2 wild-type, heterozygous, and null E18.5 kidneys on the Pygo1 null background. Genotype Ureteric tip Condensing mesenchyme Ureteric tips/mm2 SD n Mesenchyme condensate size (μm) SD n Pygo2 +/+ 196 8.36 3 16.2 1.09 3 Pygo2 +/- 191 11.6 7 15.6 1.18 5 Pygo2 -/- 147* 12.2 7 20.9 * 1.12 5 *Significant change (P < 0.01) between the three groups. SD, Standard deviation; n, number Confocal analysis also
T5931 11622-11623 sentence denotes
T5930 11621-11622 . denotes .
T5929 11615-11621 JJ denotes normal
T5928 11599-11605 NNS denotes bodies
T5927 11591-11592 HYPH denotes -
T5926 11592-11598 VBN denotes shaped
T5925 11590-11591 NN denotes S
T5924 11586-11589 CC denotes and
T5923 11584-11586 , denotes ,
T5922 11578-11584 NNS denotes bodies
T5921 11570-11571 HYPH denotes -
T5920 11571-11577 VBN denotes shaped
T5919 11565-11570 NN denotes comma
T5918 11563-11565 , denotes ,
T5917 11555-11563 NNS denotes vesicles
T5916 11549-11554 JJ denotes renal
T5915 11539-11548 VBG denotes including
T5914 11537-11539 , denotes ,
T5913 11524-11537 NN denotes nephrogenesis
T5912 11521-11523 IN denotes of
T5911 11606-11614 VBD denotes appeared
T5910 11510-11520 NNS denotes structures
T5909 11497-11509 JJ denotes Intermediate
T5908 11496-11622 sentence denotes Intermediate structures of nephrogenesis, including renal vesicles, comma-shaped bodies, and S-shaped bodies appeared normal.
T5907 11495-11496 . denotes .
T5906 11489-11495 JJ denotes normal
T5905 11486-11488 IN denotes as
T5904 11484-11486 , denotes ,
T5903 11478-11484 NN denotes kidney
T5902 11474-11477 DT denotes the
T5901 11471-11473 IN denotes of
T5900 11463-11470 NN denotes medulla
T5899 11459-11462 DT denotes the
T5898 11454-11458 IN denotes into
T5897 11444-11453 VBG denotes extending
T5896 11440-11443 CC denotes and
T5895 11438-11439 -RRB- denotes ]
T5894 11436-11438 CD denotes 16
T5893 11435-11436 -LRB- denotes [
T4761 8875-8879 DT denotes both
T4760 8871-8874 IN denotes for
T4759 8853-8863 VBG denotes developing
T4758 8864-8870 NN denotes kidney
T4757 8849-8852 DT denotes the
T4756 8846-8848 IN denotes of
T4755 8836-8839 DT denotes all
T4754 8840-8845 NNS denotes cells
T4753 8824-8835 RB denotes essentially
T4752 8821-8823 IN denotes in
T4751 8808-8811 VBD denotes was
T4750 8812-8820 VBN denotes detected
T4749 8791-8798 JJ denotes nuclear
T4748 8799-8807 NN denotes staining
T4747 8779-8790 JJ denotes significant
T4746 8775-8778 CC denotes and
T4745 8773-8775 , denotes ,
T4744 8768-8773 NNS denotes cells
T4743 8760-8767 JJ denotes stromal
T4742 8757-8759 IN denotes in
T4741 8748-8751 VBD denotes was
T4740 8746-8748 , denotes ,
T4739 8741-8746 NN denotes Pygo2
T4738 8724-8730 JJR denotes lesser
T4737 8731-8737 NN denotes degree
T4736 8722-8723 DT denotes a
T4735 8738-8740 IN denotes of
T4734 8719-8721 IN denotes to
T4733 8715-8718 CC denotes and
T4732 8713-8715 , denotes ,
T4731 8708-8713 NN denotes Pygo1
T4730 8705-8707 IN denotes of
T4729 8752-8756 VBN denotes seen
T4728 8694-8704 NN denotes expression
T4727 8687-8693 VBN denotes Raised
T4726 8686-8889 sentence denotes Raised expression of Pygo1, and to a lesser degree of Pygo2, was seen in stromal cells, and significant nuclear staining was detected in essentially all cells of the developing kidney for both proteins.
T4725 8685-8686 . denotes .
T4724 8684-8685 -RRB- denotes )
T4723 8683-8684 CD denotes 2
T4722 8676-8682 NN denotes Figure
T4721 8675-8676 -LRB- denotes (
T4720 8669-8674 NNS denotes cells
T4719 8661-8668 JJ denotes stromal
T4718 8657-8660 CC denotes and
T4717 8655-8657 , denotes ,
T4716 8645-8655 NN denotes mesenchyme
T4715 8637-8644 NN denotes capping
T4714 8635-8637 , denotes ,
T4713 8623-8631 JJ denotes ureteric
T4712 8632-8635 NN denotes bud
T4711 8619-8622 DT denotes the
T4710 8616-8618 IN denotes in
T4709 8607-8615 NN denotes proteins
T4708 8599-8606 VBN denotes encoded
T4707 8596-8598 IN denotes of
T4706 8583-8595 NN denotes localization
T4705 8575-8582 JJ denotes nuclear
T4704 8567-8574 VBG denotes showing
T4703 8565-8567 , denotes ,
T4702 8549-8555 RB denotes widely
T4701 8544-8548 VBD denotes were
T4700 8556-8565 VBN denotes expressed
T4699 8538-8543 NNS denotes genes
T4698 8533-8537 DT denotes Both
T4697 8532-8686 sentence denotes Both genes were widely expressed, showing nuclear localization of encoded proteins in the ureteric bud, capping mesenchyme, and stromal cells (Figure 2).
T4696 8531-8532 . denotes .
T4695 8514-8524 VBG denotes developing
T4694 8525-8531 NN denotes kidney
T4693 8510-8513 DT denotes the
T4692 8507-8509 IN denotes in
T4691 8495-8500 NN denotes Pygo2
T4690 8491-8494 CC denotes and
T4689 8485-8490 NN denotes Pygo1
T4688 8501-8506 NNS denotes genes
T4687 8481-8484 DT denotes the
T4686 8478-8480 IN denotes of
T4685 8458-8468 NN denotes expression
T4684 8469-8477 NNS denotes patterns
T4683 8454-8457 DT denotes the
T4682 8440-8446 RBR denotes better
T4681 8447-8453 VB denotes define
T4680 8437-8439 TO denotes to
T4679 8418-8436 NN denotes immunofluorescence
T4678 8410-8412 PRP denotes we
T4677 8408-8410 , denotes ,
T4676 8402-8408 NN denotes report
T4675 8397-8401 DT denotes this
T4674 8413-8417 VBD denotes used
T4673 8394-8396 IN denotes In
T4672 8393-8532 sentence denotes In this report, we used immunofluorescence to better define the expression patterns of the Pygo1 and Pygo2 genes in the developing kidney.
T4671 8392-8393 . denotes .
T4670 8391-8392 -RRB- denotes )
T4669 8389-8391 , denotes ,
T4668 8383-8389 NN denotes GUDMAP
T4667 8380-8382 IN denotes to
T4666 8367-8379 NN denotes contribution
T4665 8365-8367 , denotes ,
T4664 8363-8365 NNP denotes AP
T4663 8355-8362 NNP denotes McMahon
T4662 8353-8355 , denotes ,
T4661 8351-8353 NNP denotes MT
T4660 8342-8350 NNP denotes Valerius
T4659 8340-8342 , denotes ,
T4658 8339-8340 NNP denotes J
T4657 8336-8338 NNP denotes Yu
T4656 8335-8336 -LRB- denotes (
T4655 8334-8335 -RRB- denotes ]
T4654 8331-8332 , denotes ,
T4653 8329-8331 CD denotes 14
T4652 8332-8334 CD denotes 16
T4651 8328-8329 -LRB- denotes [
T4650 8322-8327 NN denotes Pygo1
T4649 8319-8321 IN denotes of
T4648 8308-8318 NN denotes expression
T4647 8295-8307 VB denotes characterize
T4646 8292-8294 TO denotes to
T4645 8281-8291 RB denotes previously
T4644 8271-8275 VBN denotes been
T4643 8267-8270 VBZ denotes has
T4642 8276-8280 VBN denotes used
T4641 8253-8266 NN denotes hybridization
T4640 8248-8252 FW denotes situ
T4639 8245-8247 FW denotes In
T4638 8244-8393 sentence denotes In situ hybridization has been used previously to characterize expression of Pygo1 [14,16](Yu J, Valerius MT, McMahon AP, contribution to GUDMAP, ).
T4637 8227-8237 VBG denotes developing
T4636 8238-8244 NN denotes kidney
T4635 8223-8226 DT denotes the
T4634 8220-8222 IN denotes in
T4633 8214-8219 NN denotes Pygo2
T4632 8210-8213 CC denotes and
T4631 8204-8209 NN denotes Pygo1
T4630 8201-8203 IN denotes of
T4629 8190-8200 NN denotes Expression
T944 6-9 CC denotes and
T945 10-15 NN denotes Pygo2
T946 22-24 IN denotes in
T947 25-28 NN denotes Wnt
T948 29-38 NN denotes signaling
T949 39-41 IN denotes in
T950 42-51 JJ denotes mammalian
T951 52-58 NN denotes kidney
T952 59-70 NN denotes development
T953 70-71 sentence denotes
T954 81-91 sentence denotes Background
T955 81-91 NN denotes Background
T956 91-239 sentence denotes The pygopus gene of Drosophila encodes an essential component of the Armadillo (β-catenin) transcription factor complex of canonical Wnt signaling.
T957 92-95 DT denotes The
T958 104-108 NN denotes gene
T959 96-103 NN denotes pygopus
T960 123-130 VBZ denotes encodes
T961 109-111 IN denotes of
T962 112-122 NNP denotes Drosophila
T963 131-133 DT denotes an
T964 144-153 NN denotes component
T965 134-143 JJ denotes essential
T966 154-156 IN denotes of
T967 157-160 DT denotes the
T968 204-211 NN denotes complex
T969 161-170 NN denotes Armadillo
T970 197-203 NN denotes factor
T971 171-172 -LRB- denotes (
T972 174-181 NN denotes catenin
T973 172-173 NN denotes β
T974 173-174 HYPH denotes -
T975 181-182 -RRB- denotes )
T976 183-196 NN denotes transcription
T977 212-214 IN denotes of
T978 215-224 JJ denotes canonical
T979 229-238 NN denotes signaling
T980 225-228 NN denotes Wnt
T981 238-239 . denotes .
T982 239-419 sentence denotes To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2.
T983 240-242 TO denotes To
T984 250-260 VB denotes understand
T985 243-249 RBR denotes better
T986 366-370 VBN denotes made
T987 261-264 DT denotes the
T988 265-274 NNS denotes functions
T989 275-277 IN denotes of
T990 278-285 NN denotes Pygopus
T991 286-294 VBN denotes mediated
T992 285-286 HYPH denotes -
T993 309-318 NN denotes signaling
T994 295-304 JJ denotes canonical
T995 305-308 NN denotes Wnt
T996 319-321 IN denotes in
T997 322-328 NN denotes kidney
T998 329-340 NN denotes development
T999 340-342 , denotes ,
T1000 342-350 VBN denotes targeted
T1001 351-360 NNS denotes mutations
T1002 361-365 VBD denotes were
T1003 371-373 IN denotes in
T1004 374-377 DT denotes the
T1005 392-401 NNS denotes orthologs
T1006 378-381 CD denotes two
T1007 382-391 JJ denotes mammalian
T1008 401-403 , denotes ,
T1009 403-408 NN denotes Pygo1
T1010 409-412 CC denotes and
T1011 413-418 NN denotes Pygo2
T1012 418-419 . denotes .
T1013 419-428 sentence denotes Results
T1014 421-428 NNS denotes Results
T1015 428-562 sentence denotes Each mutation deleted >80% of the coding sequence, including the critical PHD domain, and almost certainly resulted in null function.
T1016 429-433 DT denotes Each
T1017 434-442 NN denotes mutation
T1018 536-544 VBD denotes resulted
T1019 443-450 VBD denotes deleted
T1020 451-452 SYM denotes >
T1021 452-454 CD denotes 80
T1022 454-455 NN denotes %
T1023 456-458 IN denotes of
T1024 459-462 DT denotes the
T1025 470-478 NN denotes sequence
T1026 463-469 NN denotes coding
T1027 478-480 , denotes ,
T1028 480-489 VBG denotes including
T1029 490-493 DT denotes the
T1030 507-513 NN denotes domain
T1031 494-502 JJ denotes critical
T1032 503-506 NN denotes PHD
T1033 513-515 , denotes ,
T1034 515-518 CC denotes and
T1035 519-525 RB denotes almost
T1036 526-535 RB denotes certainly
T1037 545-547 IN denotes in
T1038 548-552 JJ denotes null
T1039 553-561 NN denotes function
T1040 561-562 . denotes .
T1041 562-773 sentence denotes Pygo2 homozygous mutants, with rare exception, died shortly after birth, with a phenotype including lens agenesis, growth retardation, altered kidney development, and in some cases exencephaly and cleft palate.
T1042 563-568 NN denotes Pygo2
T1043 569-579 JJ denotes homozygous
T1044 580-587 NNS denotes mutants
T1045 610-614 VBD denotes died
T1046 587-589 , denotes ,
T1047 589-593 IN denotes with
T1048 594-598 JJ denotes rare
T1049 599-608 NN denotes exception
T1050 608-610 , denotes ,
T1051 615-622 RB denotes shortly
T1052 623-628 IN denotes after
T1053 629-634 NN denotes birth
T1054 634-636 , denotes ,
T1055 636-640 IN denotes with
T1056 641-642 DT denotes a
T1057 643-652 NN denotes phenotype
T1058 653-662 VBG denotes including
T1059 663-667 NN denotes lens
T1060 668-676 NN denotes agenesis
T1061 676-678 , denotes ,
T1062 678-684 NN denotes growth
T1063 685-696 NN denotes retardation
T1064 696-698 , denotes ,
T1065 698-705 VBN denotes altered
T1066 713-724 NN denotes development
T1067 706-712 NN denotes kidney
T1068 724-726 , denotes ,
T1069 726-729 CC denotes and
T1070 730-732 IN denotes in
T1071 744-755 NN denotes exencephaly
T1072 733-737 DT denotes some
T1073 738-743 NNS denotes cases
T1074 756-759 CC denotes and
T1075 760-765 VBN denotes cleft
T1076 766-772 NN denotes palate
T1077 772-773 . denotes .
T1078 773-875 sentence denotes Pygo1 homozygous mutants, however, were viable and fertile, with no detectable developmental defects.
T1079 774-779 NN denotes Pygo1
T1080 780-790 JJ denotes homozygous
T1081 791-798 NNS denotes mutants
T1082 809-813 VBD denotes were
T1083 798-800 , denotes ,
T1084 800-807 RB denotes however
T1085 807-809 , denotes ,
T1086 814-820 JJ denotes viable
T1087 821-824 CC denotes and
T1088 825-832 JJ denotes fertile
T1089 832-834 , denotes ,
T1090 834-838 IN denotes with
T1091 839-841 DT denotes no
T1092 867-874 NNS denotes defects
T1093 842-852 JJ denotes detectable
T1094 853-866 JJ denotes developmental
T1095 874-875 . denotes .
T1096 875-963 sentence denotes Double Pygo1/Pygo2 homozygous mutants showed no apparent synergy in phenotype severity.
T1097 876-882 JJ denotes Double
T1098 889-894 NN denotes Pygo2
T1099 883-888 NN denotes Pygo1
T1100 888-889 HYPH denotes /
T1101 895-905 JJ denotes homozygous
T1102 906-913 NNS denotes mutants
T1103 914-920 VBD denotes showed
T1104 921-923 DT denotes no
T1105 933-940 NN denotes synergy
T1106 924-932 JJ denotes apparent
T1107 941-943 IN denotes in
T1108 944-953 NN denotes phenotype
T1109 954-962 NN denotes severity
T1110 962-963 . denotes .
T1111 963-1143 sentence denotes The BAT-gal transgene reporter of canonical Wnt signaling showed reduced levels of expression in Pygo1-/-/Pygo2-/- mutants, with tissue-specific variation in degree of diminution.
T1112 964-967 DT denotes The
T1113 986-994 NN denotes reporter
T1114 968-971 NN denotes BAT
T1115 972-975 NN denotes gal
T1116 971-972 HYPH denotes -
T1117 976-985 NN denotes transgene
T1118 1022-1028 VBD denotes showed
T1119 995-997 IN denotes of
T1120 998-1007 JJ denotes canonical
T1121 1012-1021 NN denotes signaling
T1122 1008-1011 NN denotes Wnt
T1123 1029-1036 VBN denotes reduced
T1124 1037-1043 NNS denotes levels
T1125 1044-1046 IN denotes of
T1126 1047-1057 NN denotes expression
T1127 1058-1060 IN denotes in
T1128 1061-1066 NN denotes Pygo1
T1129 1079-1086 NNS denotes mutants
T1130 1066-1067 SYM denotes -
T1131 1067-1068 HYPH denotes /
T1132 1068-1069 SYM denotes -
T1133 1069-1070 HYPH denotes /
T1134 1070-1075 NN denotes Pygo2
T1135 1075-1076 SYM denotes -
T1136 1076-1077 HYPH denotes /
T1137 1077-1078 SYM denotes -
T1138 1086-1088 , denotes ,
T1139 1088-1092 IN denotes with
T1140 1093-1099 NN denotes tissue
T1141 1100-1108 JJ denotes specific
T1142 1099-1100 HYPH denotes -
T1143 1109-1118 NN denotes variation
T1144 1119-1121 IN denotes in
T1145 1122-1128 NN denotes degree
T1146 1129-1131 IN denotes of
T1147 1132-1142 NN denotes diminution
T1148 1142-1143 . denotes .
T1149 1143-1281 sentence denotes The Pygo1 and Pygo2 genes both showed widespread expression in the developing kidney, with raised levels in the stromal cell compartment.
T1150 1144-1147 DT denotes The
T1151 1164-1169 NNS denotes genes
T1152 1148-1153 NN denotes Pygo1
T1153 1154-1157 CC denotes and
T1154 1158-1163 NN denotes Pygo2
T1155 1175-1181 VBD denotes showed
T1156 1170-1174 RB denotes both
T1157 1182-1192 JJ denotes widespread
T1158 1193-1203 NN denotes expression
T1159 1204-1206 IN denotes in
T1160 1207-1210 DT denotes the
T1161 1222-1228 NN denotes kidney
T1162 1211-1221 VBG denotes developing
T1163 1228-1230 , denotes ,
T1164 1230-1234 IN denotes with
T1165 1235-1241 VBN denotes raised
T1166 1242-1248 NNS denotes levels
T1167 1249-1251 IN denotes in
T1168 1252-1255 DT denotes the
T1169 1269-1280 NN denotes compartment
T1170 1256-1263 JJ denotes stromal
T1171 1264-1268 NN denotes cell
T1172 1280-1281 . denotes .
T1173 1281-1421 sentence denotes Confocal analysis of the double mutant kidneys showed disturbance of both the ureteric bud and metanephric mesenchyme-derived compartments.
T1174 1282-1290 JJ denotes Confocal
T1175 1291-1299 NN denotes analysis
T1176 1329-1335 VBD denotes showed
T1177 1300-1302 IN denotes of
T1178 1303-1306 DT denotes the
T1179 1321-1328 NNS denotes kidneys
T1180 1307-1313 JJ denotes double
T1181 1314-1320 NN denotes mutant
T1182 1336-1347 NN denotes disturbance
T1183 1348-1350 IN denotes of
T1184 1351-1355 CC denotes both
T1185 1408-1420 NNS denotes compartments
T1186 1356-1359 DT denotes the
T1187 1360-1368 JJ denotes ureteric
T1188 1369-1372 NN denotes bud
T1189 1400-1407 VBN denotes derived
T1190 1373-1376 CC denotes and
T1191 1377-1388 JJ denotes metanephric
T1192 1389-1399 NN denotes mesenchyme
T1193 1399-1400 HYPH denotes -
T1194 1420-1421 . denotes .
T1195 1421-1586 sentence denotes Branching morphogenesis of the ureteric bud was altered, with expanded tips and reduced tip density, probably contributing to the smaller size of the mutant kidney.
T1196 1422-1431 VBG denotes Branching
T1197 1432-1445 NN denotes morphogenesis
T1198 1470-1477 VBN denotes altered
T1199 1446-1448 IN denotes of
T1200 1449-1452 DT denotes the
T1201 1462-1465 NN denotes bud
T1202 1453-1461 JJ denotes ureteric
T1203 1466-1469 VBD denotes was
T1204 1477-1479 , denotes ,
T1205 1479-1483 IN denotes with
T1206 1484-1492 VBN denotes expanded
T1207 1493-1497 NNS denotes tips
T1208 1498-1501 CC denotes and
T1209 1502-1509 VBN denotes reduced
T1210 1514-1521 NN denotes density
T1211 1510-1513 NN denotes tip
T1212 1521-1523 , denotes ,
T1213 1523-1531 RB denotes probably
T1214 1532-1544 VBG denotes contributing
T1215 1545-1547 IN denotes to
T1216 1548-1551 DT denotes the
T1217 1560-1564 NN denotes size
T1218 1552-1559 JJR denotes smaller
T1219 1565-1567 IN denotes of
T1220 1568-1571 DT denotes the
T1221 1579-1585 NN denotes kidney
T1222 1572-1578 NN denotes mutant
T1223 1585-1586 . denotes .
T1224 1586-1684 sentence denotes In addition, there was an expansion of the zone of condensed mesenchyme capping the ureteric bud.
T1225 1587-1589 IN denotes In
T1226 1606-1609 VBD denotes was
T1227 1590-1598 NN denotes addition
T1228 1598-1600 , denotes ,
T1229 1600-1605 EX denotes there
T1230 1610-1612 DT denotes an
T1231 1613-1622 NN denotes expansion
T1232 1623-1625 IN denotes of
T1233 1626-1629 DT denotes the
T1234 1630-1634 NN denotes zone
T1235 1635-1637 IN denotes of
T1236 1638-1647 VBN denotes condensed
T1237 1648-1658 NN denotes mesenchyme
T1238 1659-1666 VBG denotes capping
T1239 1667-1670 DT denotes the
T1240 1680-1683 NN denotes bud
T1241 1671-1679 JJ denotes ureteric
T1242 1683-1684 . denotes .
T1243 1684-1732 sentence denotes Nephron formation, however, proceeded normally.
T1244 1685-1692 NN denotes Nephron
T1245 1693-1702 NN denotes formation
T1246 1713-1722 VBD denotes proceeded
T1247 1702-1704 , denotes ,
T1248 1704-1711 RB denotes however
T1249 1711-1713 , denotes ,
T1250 1723-1731 RB denotes normally
T1251 1731-1732 . denotes .
T1252 1732-1908 sentence denotes Microarray analysis showed changed expression of several genes, including Cxcl13, Slc5a2, Klk5, Ren2 and Timeless, which represent candidate Wnt targets in kidney development.
T1253 1733-1743 NN denotes Microarray
T1254 1744-1752 NN denotes analysis
T1255 1753-1759 VBD denotes showed
T1256 1760-1767 VBN denotes changed
T1257 1768-1778 NN denotes expression
T1258 1779-1781 IN denotes of
T1259 1782-1789 JJ denotes several
T1260 1790-1795 NNS denotes genes
T1261 1795-1797 , denotes ,
T1262 1797-1806 VBG denotes including
T1263 1807-1813 NN denotes Cxcl13
T1264 1813-1815 , denotes ,
T1265 1815-1821 NN denotes Slc5a2
T1266 1821-1823 , denotes ,
T1267 1823-1827 NN denotes Klk5
T1268 1827-1829 , denotes ,
T1269 1829-1833 NN denotes Ren2
T1270 1834-1837 CC denotes and
T1271 1838-1846 NN denotes Timeless
T1272 1846-1848 , denotes ,
T1273 1848-1853 WDT denotes which
T1274 1854-1863 VBP denotes represent
T1275 1864-1873 NN denotes candidate
T1276 1878-1885 NNS denotes targets
T1277 1874-1877 NN denotes Wnt
T1278 1886-1888 IN denotes in
T1279 1889-1895 NN denotes kidney
T1280 1896-1907 NN denotes development
T1281 1907-1908 . denotes .
T1282 1908-1920 sentence denotes Conclusion
T1283 1910-1920 NN denotes Conclusion
T1284 1920-2043 sentence denotes The mammalian Pygopus genes are required for normal branching morphogenesis of the ureteric bud during kidney development.
T1285 1921-1924 DT denotes The
T1286 1943-1948 NNS denotes genes
T1287 1925-1934 JJ denotes mammalian
T1288 1935-1942 NN denotes Pygopus
T1289 1953-1961 VBN denotes required
T1290 1949-1952 VBP denotes are
T1291 1962-1965 IN denotes for
T1292 1966-1972 JJ denotes normal
T1293 1983-1996 NN denotes morphogenesis
T1294 1973-1982 NN denotes branching
T1295 1997-1999 IN denotes of
T1296 2000-2003 DT denotes the
T1297 2013-2016 NN denotes bud
T1298 2004-2012 JJ denotes ureteric
T1299 2017-2023 IN denotes during
T1300 2024-2030 NN denotes kidney
T1301 2031-2042 NN denotes development
T1302 2042-2043 . denotes .
T1303 2043-2240 sentence denotes Nevertheless, the relatively mild phenotype observed in the kidney, as well as other organ systems, indicates a striking evolutionary divergence of Pygopus function between mammals and Drosophila.
T1304 2044-2056 RB denotes Nevertheless
T1305 2144-2153 VBZ denotes indicates
T1306 2056-2058 , denotes ,
T1307 2058-2061 DT denotes the
T1308 2078-2087 NN denotes phenotype
T1309 2062-2072 RB denotes relatively
T1310 2073-2077 JJ denotes mild
T1311 2088-2096 VBN denotes observed
T1312 2097-2099 IN denotes in
T1313 2100-2103 DT denotes the
T1314 2104-2110 NN denotes kidney
T1315 2110-2112 , denotes ,
T1316 2112-2114 RB denotes as
T1317 2120-2122 IN denotes as
T1318 2115-2119 RB denotes well
T1319 2123-2128 JJ denotes other
T1320 2135-2142 NNS denotes systems
T1321 2129-2134 NN denotes organ
T1322 2142-2144 , denotes ,
T1323 2154-2155 DT denotes a
T1324 2178-2188 NN denotes divergence
T1325 2156-2164 JJ denotes striking
T1326 2165-2177 JJ denotes evolutionary
T1327 2189-2191 IN denotes of
T1328 2192-2199 NN denotes Pygopus
T1329 2200-2208 NN denotes function
T1330 2209-2216 IN denotes between
T1331 2217-2224 NNS denotes mammals
T1332 2225-2228 CC denotes and
T1333 2229-2239 NNP denotes Drosophila
T1334 2239-2240 . denotes .
T1335 2240-2447 sentence denotes In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity.
T1336 2241-2243 IN denotes In
T1337 2294-2302 VBN denotes required
T1338 2244-2251 NNS denotes mammals
T1339 2251-2253 , denotes ,
T1340 2253-2256 DT denotes the
T1341 2269-2274 NNS denotes genes
T1342 2257-2262 NN denotes Pygo1
T1343 2263-2268 NN denotes Pygo2
T1344 2262-2263 HYPH denotes /
T1345 2275-2278 VBP denotes are
T1346 2279-2282 RB denotes not
T1347 2283-2293 RB denotes absolutely
T1348 2303-2306 IN denotes for
T1349 2307-2316 JJ denotes canonical
T1350 2321-2330 NN denotes signaling
T1351 2317-2320 NN denotes Wnt
T1352 2331-2333 IN denotes in
T1353 2334-2338 JJS denotes most
T1354 2350-2357 NNS denotes systems
T1355 2339-2349 VBG denotes developing
T1356 2357-2359 , denotes ,
T1357 2359-2362 CC denotes but
T1358 2363-2369 RB denotes rather
T1359 2370-2378 VBP denotes function
T1360 2379-2381 IN denotes as
T1361 2382-2394 JJ denotes quantitative
T1362 2395-2406 NNS denotes transducers
T1363 2406-2408 , denotes ,
T1364 2408-2410 CC denotes or
T1365 2411-2421 NNS denotes modulators
T1366 2421-2423 , denotes ,
T1367 2423-2425 IN denotes of
T1368 2426-2429 NN denotes Wnt
T1369 2430-2436 NN denotes signal
T1370 2437-2446 NN denotes intensity
T1371 2446-2447 . denotes .
T2638 2460-2463 NN denotes Wnt
T2639 2464-2473 NN denotes signaling
T2640 2474-2476 VBZ denotes is
T2641 2477-2479 IN denotes of
T2642 2480-2488 JJ denotes critical
T2643 2489-2499 NN denotes importance
T2644 2500-2502 IN denotes in
T2645 2503-2510 JJ denotes several
T2646 2511-2517 NNS denotes stages
T2647 2518-2520 IN denotes of
T2648 2521-2527 NN denotes kidney
T2649 2528-2539 NN denotes development
T2650 2539-2540 . denotes .
T2651 2540-2647 sentence denotes Mutual inductive interactions between the ureteric bud and metanephric mesenchyme drive nephrogenesis [1].
T2652 2541-2547 JJ denotes Mutual
T2653 2558-2570 NNS denotes interactions
T2654 2548-2557 JJ denotes inductive
T2655 2623-2628 VBP denotes drive
T2656 2571-2578 IN denotes between
T2657 2579-2582 DT denotes the
T2658 2592-2595 NN denotes bud
T2659 2583-2591 JJ denotes ureteric
T2660 2596-2599 CC denotes and
T2661 2600-2611 JJ denotes metanephric
T2662 2612-2622 NN denotes mesenchyme
T2663 2629-2642 NN denotes nephrogenesis
T2664 2643-2644 -LRB- denotes [
T2665 2644-2645 CD denotes 1
T2666 2645-2646 -RRB- denotes ]
T2667 2646-2647 . denotes .
T2668 2647-2756 sentence denotes The ureteric bud synthesizes Wnt9b, which is essential for induction of the mesenchyme to form nephrons [2].
T2669 2648-2651 DT denotes The
T2670 2661-2664 NN denotes bud
T2671 2652-2660 JJ denotes ureteric
T2672 2665-2676 VBZ denotes synthesizes
T2673 2677-2682 NN denotes Wnt9b
T2674 2682-2684 , denotes ,
T2675 2684-2689 WDT denotes which
T2676 2690-2692 VBZ denotes is
T2677 2693-2702 JJ denotes essential
T2678 2703-2706 IN denotes for
T2679 2707-2716 NN denotes induction
T2680 2717-2719 IN denotes of
T2681 2720-2723 DT denotes the
T2682 2724-2734 NN denotes mesenchyme
T2683 2735-2737 TO denotes to
T2684 2738-2742 VB denotes form
T2685 2743-2751 NNS denotes nephrons
T2686 2752-2753 -LRB- denotes [
T2687 2753-2754 CD denotes 2
T2688 2754-2755 -RRB- denotes ]
T2689 2755-2756 . denotes .
T2690 2756-2851 sentence denotes Wnt4 is made by the induced metanephric mesenchyme and is also required for nephrogenesis [3].
T2691 2757-2761 NN denotes Wnt4
T2692 2765-2769 VBN denotes made
T2693 2762-2764 VBZ denotes is
T2694 2770-2772 IN denotes by
T2695 2773-2776 DT denotes the
T2696 2797-2807 NN denotes mesenchyme
T2697 2777-2784 VBN denotes induced
T2698 2785-2796 JJ denotes metanephric
T2699 2808-2811 CC denotes and
T2700 2812-2814 VBZ denotes is
T2701 2820-2828 VBN denotes required
T2702 2815-2819 RB denotes also
T2703 2829-2832 IN denotes for
T2704 2833-2846 NN denotes nephrogenesis
T2705 2847-2848 -LRB- denotes [
T2706 2848-2849 CD denotes 3
T2707 2849-2850 -RRB- denotes ]
T2708 2850-2851 . denotes .
T2709 2851-3054 sentence denotes Furthermore, Wnt11, secreted by the ureteric bud tips, participates in a positive feedback loop promoting glial cell line-derived neurotrophic factor (GDNF) expression by the metanephric mesenchyme [4].
T2710 2852-2863 RB denotes Furthermore
T2711 2907-2919 VBZ denotes participates
T2712 2863-2865 , denotes ,
T2713 2865-2870 NN denotes Wnt11
T2714 2870-2872 , denotes ,
T2715 2872-2880 VBN denotes secreted
T2716 2881-2883 IN denotes by
T2717 2884-2887 DT denotes the
T2718 2901-2905 NNS denotes tips
T2719 2888-2896 JJ denotes ureteric
T2720 2897-2900 NN denotes bud
T2721 2905-2907 , denotes ,
T2722 2920-2922 IN denotes in
T2723 2923-2924 DT denotes a
T2724 2943-2947 NN denotes loop
T2725 2925-2933 JJ denotes positive
T2726 2934-2942 NN denotes feedback
T2727 2948-2957 VBG denotes promoting
T2728 2958-2963 JJ denotes glial
T2729 2969-2973 NN denotes line
T2730 2964-2968 NN denotes cell
T2731 2974-2981 VBN denotes derived
T2732 2973-2974 HYPH denotes -
T2733 2995-3001 NN denotes factor
T2734 2982-2994 JJ denotes neurotrophic
T2735 3009-3019 NN denotes expression
T2736 3002-3003 -LRB- denotes (
T2737 3003-3007 NN denotes GDNF
T2738 3007-3008 -RRB- denotes )
T2739 3020-3022 IN denotes by
T2740 3023-3026 DT denotes the
T2741 3039-3049 NN denotes mesenchyme
T2742 3027-3038 JJ denotes metanephric
T2743 3050-3051 -LRB- denotes [
T2744 3051-3052 CD denotes 4
T2745 3052-3053 -RRB- denotes ]
T2746 3053-3054 . denotes .
T2747 3054-3198 sentence denotes Mutations in Wnt9b or Wnt4 result in a dramatic block in nephron formation, while Wnt11 mutants show a significant reduction in nephron number.
T2748 3055-3064 NNS denotes Mutations
T2749 3082-3088 VBP denotes result
T2750 3065-3067 IN denotes in
T2751 3068-3073 NN denotes Wnt9b
T2752 3074-3076 CC denotes or
T2753 3077-3081 NN denotes Wnt4
T2754 3089-3091 IN denotes in
T2755 3092-3093 DT denotes a
T2756 3103-3108 NN denotes block
T2757 3094-3102 JJ denotes dramatic
T2758 3109-3111 IN denotes in
T2759 3112-3119 NN denotes nephron
T2760 3120-3129 NN denotes formation
T2761 3129-3131 , denotes ,
T2762 3131-3136 IN denotes while
T2763 3151-3155 VBP denotes show
T2764 3137-3142 NN denotes Wnt11
T2765 3143-3150 NNS denotes mutants
T2766 3156-3157 DT denotes a
T2767 3170-3179 NN denotes reduction
T2768 3158-3169 JJ denotes significant
T2769 3180-3182 IN denotes in
T2770 3183-3190 NN denotes nephron
T2771 3191-3197 NN denotes number
T2772 3197-3198 . denotes .
T2773 3198-3431 sentence denotes It is interesting to note that Wnt4 and Wnt11 have been shown to signal, at least in some cases, through noncanonical pathways [5-7], while there is evidence indicating that Wnt9b activates canonical Wnt signaling in the kidney [2].
T2774 3199-3201 PRP denotes It
T2775 3202-3204 VBZ denotes is
T2776 3205-3216 JJ denotes interesting
T2777 3217-3219 TO denotes to
T2778 3220-3224 VB denotes note
T2779 3225-3229 IN denotes that
T2780 3255-3260 VBN denotes shown
T2781 3230-3234 NN denotes Wnt4
T2782 3235-3238 CC denotes and
T2783 3239-3244 NN denotes Wnt11
T2784 3245-3249 VBP denotes have
T2785 3250-3254 VBN denotes been
T2786 3261-3263 TO denotes to
T2787 3264-3270 VB denotes signal
T2788 3270-3272 , denotes ,
T2789 3272-3274 RB denotes at
T2790 3275-3280 RBS denotes least
T2791 3281-3283 IN denotes in
T2792 3284-3288 DT denotes some
T2793 3289-3294 NNS denotes cases
T2794 3294-3296 , denotes ,
T2795 3296-3303 IN denotes through
T2796 3304-3316 JJ denotes noncanonical
T2797 3317-3325 NNS denotes pathways
T2798 3326-3327 -LRB- denotes [
T2799 3327-3328 CD denotes 5
T2800 3328-3329 SYM denotes -
T2801 3329-3330 CD denotes 7
T2802 3330-3331 -RRB- denotes ]
T2803 3331-3333 , denotes ,
T2804 3333-3338 IN denotes while
T2805 3345-3347 VBZ denotes is
T2806 3339-3344 EX denotes there
T2807 3348-3356 NN denotes evidence
T2808 3357-3367 VBG denotes indicating
T2809 3368-3372 IN denotes that
T2810 3379-3388 VBZ denotes activates
T2811 3373-3378 NN denotes Wnt9b
T2812 3389-3398 JJ denotes canonical
T2813 3403-3412 NN denotes signaling
T2814 3399-3402 NN denotes Wnt
T2815 3413-3415 IN denotes in
T2816 3416-3419 DT denotes the
T2817 3420-3426 NN denotes kidney
T2818 3427-3428 -LRB- denotes [
T2819 3428-3429 CD denotes 2
T2820 3429-3430 -RRB- denotes ]
T2821 3430-3431 . denotes .
T2822 3431-3560 sentence denotes Genetic studies in Drosophila have identified the Pygopus (Pygo) gene as a critical component of canonical Wnt signaling [8-11].
T2823 3432-3439 JJ denotes Genetic
T2824 3440-3447 NNS denotes studies
T2825 3467-3477 VBN denotes identified
T2826 3448-3450 IN denotes in
T2827 3451-3461 NNP denotes Drosophila
T2828 3462-3466 VBP denotes have
T2829 3478-3481 DT denotes the
T2830 3497-3501 NN denotes gene
T2831 3482-3489 NN denotes Pygopus
T2832 3490-3491 -LRB- denotes (
T2833 3491-3495 NN denotes Pygo
T2834 3495-3496 -RRB- denotes )
T2835 3502-3504 IN denotes as
T2836 3505-3506 DT denotes a
T2837 3516-3525 NN denotes component
T2838 3507-3515 JJ denotes critical
T2839 3526-3528 IN denotes of
T2840 3529-3538 JJ denotes canonical
T2841 3543-3552 NN denotes signaling
T2842 3539-3542 NN denotes Wnt
T2843 3553-3554 -LRB- denotes [
T2844 3554-3555 CD denotes 8
T2845 3555-3556 SYM denotes -
T2846 3556-3558 CD denotes 11
T2847 3558-3559 -RRB- denotes ]
T2848 3559-3560 . denotes .
T2849 3560-3727 sentence denotes Pygo and Lgs interact with β-catenin during the formation of the canonical transcriptional complex and are required for accumulation of β-catenin in the nucleus [12].
T2850 3561-3565 NN denotes Pygo
T2851 3574-3582 VBP denotes interact
T2852 3566-3569 CC denotes and
T2853 3570-3573 NN denotes Lgs
T2854 3583-3587 IN denotes with
T2855 3588-3589 NN denotes β
T2856 3590-3597 NN denotes catenin
T2857 3589-3590 HYPH denotes -
T2858 3598-3604 IN denotes during
T2859 3605-3608 DT denotes the
T2860 3609-3618 NN denotes formation
T2861 3619-3621 IN denotes of
T2862 3622-3625 DT denotes the
T2863 3652-3659 NN denotes complex
T2864 3626-3635 JJ denotes canonical
T2865 3636-3651 JJ denotes transcriptional
T2866 3660-3663 CC denotes and
T2867 3664-3667 VBP denotes are
T2868 3668-3676 VBN denotes required
T2869 3677-3680 IN denotes for
T2870 3681-3693 NN denotes accumulation
T2871 3694-3696 IN denotes of
T2872 3697-3698 NN denotes β
T2873 3699-3706 NN denotes catenin
T2874 3698-3699 HYPH denotes -
T2875 3707-3709 IN denotes in
T2876 3710-3713 DT denotes the
T2877 3714-3721 NN denotes nucleus
T2878 3722-3723 -LRB- denotes [
T2879 3723-3725 CD denotes 12
T2880 3725-3726 -RRB- denotes ]
T2881 3726-3727 . denotes .
T2882 3727-3856 sentence denotes Lgs binds the central armadillo repeats of β-catenin, while Pygo interacts with Lgs, mediating activation of Wnt targets [9,13].
T2883 3728-3731 NN denotes Lgs
T2884 3732-3737 VBZ denotes binds
T2885 3738-3741 DT denotes the
T2886 3760-3767 NNS denotes repeats
T2887 3742-3749 JJ denotes central
T2888 3750-3759 NN denotes armadillo
T2889 3768-3770 IN denotes of
T2890 3771-3772 NN denotes β
T2891 3773-3780 NN denotes catenin
T2892 3772-3773 HYPH denotes -
T2893 3780-3782 , denotes ,
T2894 3782-3787 IN denotes while
T2895 3793-3802 VBZ denotes interacts
T2896 3788-3792 NN denotes Pygo
T2897 3803-3807 IN denotes with
T2898 3808-3811 NN denotes Lgs
T2899 3811-3813 , denotes ,
T2900 3813-3822 VBG denotes mediating
T2901 3823-3833 NN denotes activation
T2902 3834-3836 IN denotes of
T2903 3837-3840 NN denotes Wnt
T2904 3841-3848 NNS denotes targets
T2905 3849-3850 -LRB- denotes [
T2906 3852-3854 CD denotes 13
T2907 3850-3851 CD denotes 9
T2908 3851-3852 , denotes ,
T2909 3854-3855 -RRB- denotes ]
T2910 3855-3856 . denotes .
T2911 3856-4011 sentence denotes The N-terminal domain of Pygo is required for Wnt transcriptional activation, while the PHD motif is required for the association of Pygo with Lgs [9,13].
T2912 3857-3860 DT denotes The
T2913 3872-3878 NN denotes domain
T2914 3861-3862 NN denotes N
T2915 3863-3871 JJ denotes terminal
T2916 3862-3863 HYPH denotes -
T2917 3890-3898 VBN denotes required
T2918 3879-3881 IN denotes of
T2919 3882-3886 NN denotes Pygo
T2920 3887-3889 VBZ denotes is
T2921 3899-3902 IN denotes for
T2922 3903-3906 NN denotes Wnt
T2923 3923-3933 NN denotes activation
T2924 3907-3922 JJ denotes transcriptional
T2925 3933-3935 , denotes ,
T2926 3935-3940 IN denotes while
T2927 3958-3966 VBN denotes required
T2928 3941-3944 DT denotes the
T2929 3949-3954 NN denotes motif
T2930 3945-3948 NN denotes PHD
T2931 3955-3957 VBZ denotes is
T2932 3967-3970 IN denotes for
T2933 3971-3974 DT denotes the
T2934 3975-3986 NN denotes association
T2935 3987-3989 IN denotes of
T2936 3990-3994 NN denotes Pygo
T2937 3995-3999 IN denotes with
T2938 4000-4003 NN denotes Lgs
T2939 4004-4005 -LRB- denotes [
T2940 4007-4009 CD denotes 13
T2941 4005-4006 CD denotes 9
T2942 4006-4007 , denotes ,
T2943 4009-4010 -RRB- denotes ]
T2944 4010-4011 . denotes .
T2945 4011-4194 sentence denotes Additionally, a putative nuclear localization signal (NLS) was identified within the N-terminal domain of Pygo, suggesting a possible role of nuclear importation of β-catenin [8,11].
T2946 4012-4024 RB denotes Additionally
T2947 4075-4085 VBN denotes identified
T2948 4024-4026 , denotes ,
T2949 4026-4027 DT denotes a
T2950 4058-4064 NN denotes signal
T2951 4028-4036 JJ denotes putative
T2952 4037-4044 JJ denotes nuclear
T2953 4045-4057 NN denotes localization
T2954 4065-4066 -LRB- denotes (
T2955 4066-4069 NN denotes NLS
T2956 4069-4070 -RRB- denotes )
T2957 4071-4074 VBD denotes was
T2958 4086-4092 IN denotes within
T2959 4093-4096 DT denotes the
T2960 4108-4114 NN denotes domain
T2961 4097-4098 NN denotes N
T2962 4099-4107 JJ denotes terminal
T2963 4098-4099 HYPH denotes -
T2964 4115-4117 IN denotes of
T2965 4118-4122 NN denotes Pygo
T2966 4122-4124 , denotes ,
T2967 4124-4134 VBG denotes suggesting
T2968 4135-4136 DT denotes a
T2969 4146-4150 NN denotes role
T2970 4137-4145 JJ denotes possible
T2971 4151-4153 IN denotes of
T2972 4154-4161 JJ denotes nuclear
T2973 4162-4173 NN denotes importation
T2974 4174-4176 IN denotes of
T2975 4177-4178 NN denotes β
T2976 4179-4186 NN denotes catenin
T2977 4178-4179 HYPH denotes -
T2978 4187-4188 -LRB- denotes [
T2979 4190-4192 CD denotes 11
T2980 4188-4189 CD denotes 8
T2981 4189-4190 , denotes ,
T2982 4192-4193 -RRB- denotes ]
T2983 4193-4194 . denotes .
T2984 4194-4373 sentence denotes Analyses of multiple aspects of the pygopus mutant phenotype indicate that this gene is dedicated to, and required for, canonical Wnt signaling during Drosophila development [9].
T2985 4195-4203 NNS denotes Analyses
T2986 4256-4264 VBP denotes indicate
T2987 4204-4206 IN denotes of
T2988 4207-4215 JJ denotes multiple
T2989 4216-4223 NNS denotes aspects
T2990 4224-4226 IN denotes of
T2991 4227-4230 DT denotes the
T2992 4246-4255 NN denotes phenotype
T2993 4231-4238 NN denotes pygopus
T2994 4239-4245 NN denotes mutant
T2995 4265-4269 IN denotes that
T2996 4283-4292 VBN denotes dedicated
T2997 4270-4274 DT denotes this
T2998 4275-4279 NN denotes gene
T2999 4280-4282 VBZ denotes is
T3000 4293-4295 IN denotes to
T3001 4295-4297 , denotes ,
T3002 4297-4300 CC denotes and
T3003 4301-4309 VBN denotes required
T3004 4310-4313 IN denotes for
T3005 4313-4315 , denotes ,
T3006 4315-4324 JJ denotes canonical
T3007 4329-4338 NN denotes signaling
T3008 4325-4328 NN denotes Wnt
T3009 4339-4345 IN denotes during
T3010 4346-4356 NNP denotes Drosophila
T3011 4357-4368 NN denotes development
T3012 4369-4370 -LRB- denotes [
T3013 4370-4371 CD denotes 9
T3014 4371-4372 -RRB- denotes ]
T3015 4372-4373 . denotes .
T3016 4373-4477 sentence denotes The mammalian genome carries two, and only two, orthologs of Drosophila Pygo, Pygo1 and Pygo2 [8,9,14].
T3017 4374-4377 DT denotes The
T3018 4388-4394 NN denotes genome
T3019 4378-4387 JJ denotes mammalian
T3020 4395-4402 VBZ denotes carries
T3021 4403-4406 CD denotes two
T3022 4422-4431 NNS denotes orthologs
T3023 4406-4408 , denotes ,
T3024 4408-4411 CC denotes and
T3025 4412-4416 RB denotes only
T3026 4417-4420 CD denotes two
T3027 4420-4422 , denotes ,
T3028 4432-4434 IN denotes of
T3029 4435-4445 NNP denotes Drosophila
T3030 4446-4450 NN denotes Pygo
T3031 4450-4452 , denotes ,
T3032 4452-4457 NN denotes Pygo1
T3033 4458-4461 CC denotes and
T3034 4462-4467 NN denotes Pygo2
T3035 4468-4469 -LRB- denotes [
T3036 4473-4475 CD denotes 14
T3037 4469-4470 CD denotes 8
T3038 4470-4471 , denotes ,
T3039 4471-4472 CD denotes 9
T3040 4472-4473 , denotes ,
T3041 4475-4476 -RRB- denotes ]
T3042 4476-4477 . denotes .
T3043 4477-4691 sentence denotes In this report, we generated targeted mutations of Pygo1 and Pygo2 to determine their functions, with a particular interest in the contributions of these genes to canonical Wnt signaling during kidney development.
T3044 4478-4480 IN denotes In
T3045 4497-4506 VBD denotes generated
T3046 4481-4485 DT denotes this
T3047 4486-4492 NN denotes report
T3048 4492-4494 , denotes ,
T3049 4494-4496 PRP denotes we
T3050 4507-4515 VBN denotes targeted
T3051 4516-4525 NNS denotes mutations
T3052 4526-4528 IN denotes of
T3053 4529-4534 NN denotes Pygo1
T3054 4535-4538 CC denotes and
T3055 4539-4544 NN denotes Pygo2
T3056 4545-4547 TO denotes to
T3057 4548-4557 VB denotes determine
T3058 4558-4563 PRP$ denotes their
T3059 4564-4573 NNS denotes functions
T3060 4573-4575 , denotes ,
T3061 4575-4579 IN denotes with
T3062 4580-4581 DT denotes a
T3063 4593-4601 NN denotes interest
T3064 4582-4592 JJ denotes particular
T3065 4602-4604 IN denotes in
T3066 4605-4608 DT denotes the
T3067 4609-4622 NNS denotes contributions
T3068 4623-4625 IN denotes of
T3069 4626-4631 DT denotes these
T3070 4632-4637 NNS denotes genes
T3071 4638-4640 IN denotes to
T3072 4641-4650 JJ denotes canonical
T3073 4655-4664 NN denotes signaling
T3074 4651-4654 NN denotes Wnt
T3075 4665-4671 IN denotes during
T3076 4672-4678 NN denotes kidney
T3077 4679-4690 NN denotes development
T3078 4690-4691 . denotes .
T3079 4691-4852 sentence denotes The resulting double-homozygous mutant embryos showed a context-dependent reduction in canonical Wnt signaling as measured by Wnt reporter transgene expression.
T3080 4692-4695 DT denotes The
T3081 4731-4738 NNS denotes embryos
T3082 4696-4705 VBG denotes resulting
T3083 4706-4712 JJ denotes double
T3084 4713-4723 JJ denotes homozygous
T3085 4712-4713 HYPH denotes -
T3086 4724-4730 NN denotes mutant
T3087 4739-4745 VBD denotes showed
T3088 4746-4747 DT denotes a
T3089 4766-4775 NN denotes reduction
T3090 4748-4755 NN denotes context
T3091 4756-4765 JJ denotes dependent
T3092 4755-4756 HYPH denotes -
T3093 4776-4778 IN denotes in
T3094 4779-4788 JJ denotes canonical
T3095 4793-4802 NN denotes signaling
T3096 4789-4792 NN denotes Wnt
T3097 4803-4805 IN denotes as
T3098 4806-4814 VBN denotes measured
T3099 4815-4817 IN denotes by
T3100 4818-4821 NN denotes Wnt
T3101 4822-4830 NN denotes reporter
T3102 4831-4840 NN denotes transgene
T3103 4841-4851 NN denotes expression
T3104 4851-4852 . denotes .
T3105 4852-4975 sentence denotes Development remained, however, surprisingly normal, with survival to birth and few apparent defects in most organ systems.
T3106 4853-4864 NN denotes Development
T3107 4865-4873 VBD denotes remained
T3108 4873-4875 , denotes ,
T3109 4875-4882 RB denotes however
T3110 4882-4884 , denotes ,
T3111 4884-4896 RB denotes surprisingly
T3112 4897-4903 JJ denotes normal
T3113 4903-4905 , denotes ,
T3114 4905-4909 IN denotes with
T3115 4910-4918 NN denotes survival
T3116 4919-4921 IN denotes to
T3117 4922-4927 NN denotes birth
T3118 4928-4931 CC denotes and
T3119 4932-4935 JJ denotes few
T3120 4945-4952 NNS denotes defects
T3121 4936-4944 JJ denotes apparent
T3122 4953-4955 IN denotes in
T3123 4956-4960 JJS denotes most
T3124 4967-4974 NNS denotes systems
T3125 4961-4966 NN denotes organ
T3126 4974-4975 . denotes .
T3127 4975-5301 sentence denotes Our phenotypic analysis focused on the kidney, which showed altered branching morphogenesis of the ureteric bud, and expansion of the zone of condensed mesenchyme surrounding the ureteric bud, yet relatively normal nephron formation, as measured by histology, confocal analysis, in situ hybridization and microarray analysis.
T3128 4976-4979 PRP$ denotes Our
T3129 4991-4999 NN denotes analysis
T3130 4980-4990 JJ denotes phenotypic
T3131 5000-5007 VBD denotes focused
T3132 5008-5010 IN denotes on
T3133 5011-5014 DT denotes the
T3134 5015-5021 NN denotes kidney
T3135 5021-5023 , denotes ,
T3136 5023-5028 WDT denotes which
T3137 5029-5035 VBD denotes showed
T3138 5036-5043 VBN denotes altered
T3139 5054-5067 NN denotes morphogenesis
T3140 5044-5053 NN denotes branching
T3141 5068-5070 IN denotes of
T3142 5071-5074 DT denotes the
T3143 5084-5087 NN denotes bud
T3144 5075-5083 JJ denotes ureteric
T3145 5087-5089 , denotes ,
T3146 5089-5092 CC denotes and
T3147 5093-5102 NN denotes expansion
T3148 5103-5105 IN denotes of
T3149 5106-5109 DT denotes the
T3150 5110-5114 NN denotes zone
T3151 5115-5117 IN denotes of
T3152 5118-5127 VBN denotes condensed
T3153 5128-5138 NN denotes mesenchyme
T3154 5139-5150 VBG denotes surrounding
T3155 5151-5154 DT denotes the
T3156 5164-5167 NN denotes bud
T3157 5155-5163 JJ denotes ureteric
T3158 5167-5169 , denotes ,
T3159 5169-5172 CC denotes yet
T3160 5173-5183 RB denotes relatively
T3161 5184-5190 JJ denotes normal
T3162 5199-5208 NN denotes formation
T3163 5191-5198 NN denotes nephron
T3164 5208-5210 , denotes ,
T3165 5210-5212 IN denotes as
T3166 5213-5221 VBN denotes measured
T3167 5222-5224 IN denotes by
T3168 5225-5234 NN denotes histology
T3169 5234-5236 , denotes ,
T3170 5236-5244 JJ denotes confocal
T3171 5245-5253 NN denotes analysis
T3172 5253-5255 , denotes ,
T3173 5255-5257 FW denotes in
T3174 5258-5262 FW denotes situ
T3175 5263-5276 NN denotes hybridization
T3176 5277-5280 CC denotes and
T3177 5281-5291 NN denotes microarray
T3178 5292-5300 NN denotes analysis
T3179 5300-5301 . denotes .
T3180 5301-5466 sentence denotes The obvious conclusion is that in mammals, unlike Drosophila, Pygopus-mediated canonical Wnt signaling is not absolutely necessary in most developing organ systems.
T3181 5302-5305 DT denotes The
T3182 5314-5324 NN denotes conclusion
T3183 5306-5313 JJ denotes obvious
T3184 5325-5327 VBZ denotes is
T3185 5328-5332 IN denotes that
T3186 5405-5407 VBZ denotes is
T3187 5333-5335 IN denotes in
T3188 5336-5343 NNS denotes mammals
T3189 5343-5345 , denotes ,
T3190 5345-5351 IN denotes unlike
T3191 5352-5362 NNP denotes Drosophila
T3192 5362-5364 , denotes ,
T3193 5364-5371 NN denotes Pygopus
T3194 5372-5380 VBN denotes mediated
T3195 5371-5372 HYPH denotes -
T3196 5395-5404 NN denotes signaling
T3197 5381-5390 JJ denotes canonical
T3198 5391-5394 NN denotes Wnt
T3199 5408-5411 RB denotes not
T3200 5412-5422 RB denotes absolutely
T3201 5423-5432 JJ denotes necessary
T3202 5433-5435 IN denotes in
T3203 5436-5440 JJS denotes most
T3204 5458-5465 NNS denotes systems
T3205 5441-5451 VBG denotes developing
T3206 5452-5457 NN denotes organ
T3207 5465-5466 . denotes .
T3498 5477-5482 NN denotes Pygo1
T3499 5493-5501 VBN denotes targeted
T3500 5483-5486 CC denotes and
T3501 5487-5492 NN denotes Pygo2
T3502 5502-5511 NNS denotes mutations
T3503 5511-5642 sentence denotes We targeted both the Pygo1 and Pygo2 genes by inserting LoxP sequences to flank critical coding regions including the PHD domains.
T3504 5512-5514 PRP denotes We
T3505 5515-5523 VBD denotes targeted
T3506 5524-5528 CC denotes both
T3507 5549-5554 NNS denotes genes
T3508 5529-5532 DT denotes the
T3509 5533-5538 NN denotes Pygo1
T3510 5539-5542 CC denotes and
T3511 5543-5548 NN denotes Pygo2
T3512 5555-5557 IN denotes by
T3513 5558-5567 VBG denotes inserting
T3514 5568-5572 NN denotes LoxP
T3515 5573-5582 NNS denotes sequences
T3516 5583-5585 TO denotes to
T3517 5586-5591 VB denotes flank
T3518 5592-5600 JJ denotes critical
T3519 5608-5615 NNS denotes regions
T3520 5601-5607 VBG denotes coding
T3521 5616-5625 VBG denotes including
T3522 5626-5629 DT denotes the
T3523 5634-5641 NNS denotes domains
T3524 5630-5633 NN denotes PHD
T3525 5641-5642 . denotes .
T3526 5642-5821 sentence denotes The resulting targeted mice were mated with transgenic CMV-Cre mice [15] to drive germline LoxP recombination, resulting in the null mutant alleles that were used for this study.
T3527 5643-5646 DT denotes The
T3528 5666-5670 NNS denotes mice
T3529 5647-5656 VBG denotes resulting
T3530 5657-5665 VBN denotes targeted
T3531 5676-5681 VBN denotes mated
T3532 5671-5675 VBD denotes were
T3533 5682-5686 IN denotes with
T3534 5687-5697 JJ denotes transgenic
T3535 5706-5710 NNS denotes mice
T3536 5698-5701 NN denotes CMV
T3537 5702-5705 NN denotes Cre
T3538 5701-5702 HYPH denotes -
T3539 5711-5712 -LRB- denotes [
T3540 5712-5714 CD denotes 15
T3541 5714-5715 -RRB- denotes ]
T3542 5716-5718 TO denotes to
T3543 5719-5724 VB denotes drive
T3544 5725-5733 NN denotes germline
T3545 5734-5738 NN denotes LoxP
T3546 5739-5752 NN denotes recombination
T3547 5752-5754 , denotes ,
T3548 5754-5763 VBG denotes resulting
T3549 5764-5766 IN denotes in
T3550 5767-5770 DT denotes the
T3551 5783-5790 NNS denotes alleles
T3552 5771-5775 JJ denotes null
T3553 5776-5782 NN denotes mutant
T3554 5791-5795 WDT denotes that
T3555 5801-5805 VBN denotes used
T3556 5796-5800 VBD denotes were
T3557 5806-5809 IN denotes for
T3558 5810-5814 DT denotes this
T3559 5815-5820 NN denotes study
T3560 5820-5821 . denotes .
T3561 5821-5981 sentence denotes PCR confirmed the deletion of the bulk of the coding sequences for both genes, including 89% of coding sequence for Pygo1 and 87% of coding sequence for Pygo2.
T3562 5822-5825 NN denotes PCR
T3563 5826-5835 VBD denotes confirmed
T3564 5836-5839 DT denotes the
T3565 5840-5848 NN denotes deletion
T3566 5849-5851 IN denotes of
T3567 5852-5855 DT denotes the
T3568 5856-5860 NN denotes bulk
T3569 5861-5863 IN denotes of
T3570 5864-5867 DT denotes the
T3571 5875-5884 NNS denotes sequences
T3572 5868-5874 VBG denotes coding
T3573 5885-5888 IN denotes for
T3574 5889-5893 DT denotes both
T3575 5894-5899 NNS denotes genes
T3576 5899-5901 , denotes ,
T3577 5901-5910 VBG denotes including
T3578 5911-5913 CD denotes 89
T3579 5913-5914 NN denotes %
T3580 5915-5917 IN denotes of
T3581 5918-5924 NN denotes coding
T3582 5925-5933 NN denotes sequence
T3583 5934-5937 IN denotes for
T3584 5938-5943 NN denotes Pygo1
T3585 5944-5947 CC denotes and
T3586 5948-5950 CD denotes 87
T3587 5950-5951 NN denotes %
T3588 5952-5954 IN denotes of
T3589 5955-5961 NN denotes coding
T3590 5962-5970 NN denotes sequence
T3591 5971-5974 IN denotes for
T3592 5975-5980 NN denotes Pygo2
T3593 5980-5981 . denotes .
T3594 5981-6128 sentence denotes Previous studies in Drosophila have shown that even a single missense mutation in the PHD domain can eliminate Pygo function in Wnt signaling [8].
T3595 5982-5990 JJ denotes Previous
T3596 5991-5998 NNS denotes studies
T3597 6018-6023 VBN denotes shown
T3598 5999-6001 IN denotes in
T3599 6002-6012 NNP denotes Drosophila
T3600 6013-6017 VBP denotes have
T3601 6024-6028 IN denotes that
T3602 6083-6092 VB denotes eliminate
T3603 6029-6033 RB denotes even
T3604 6052-6060 NN denotes mutation
T3605 6034-6035 DT denotes a
T3606 6036-6042 JJ denotes single
T3607 6043-6051 NN denotes missense
T3608 6061-6063 IN denotes in
T3609 6064-6067 DT denotes the
T3610 6072-6078 NN denotes domain
T3611 6068-6071 NN denotes PHD
T3612 6079-6082 MD denotes can
T3613 6093-6097 NN denotes Pygo
T3614 6098-6106 NN denotes function
T3615 6107-6109 IN denotes in
T3616 6110-6113 NN denotes Wnt
T3617 6114-6123 NN denotes signaling
T3618 6124-6125 -LRB- denotes [
T3619 6125-6126 CD denotes 8
T3620 6126-6127 -RRB- denotes ]
T3621 6127-6128 . denotes .
T4091 6130-6135 NN denotes Pygo1
T4092 6146-6152 NN denotes mutant
T4093 6136-6139 CC denotes and
T4094 6140-6145 NN denotes Pygo2
T4095 6153-6163 NNS denotes phenotypes
T4096 6163-6256 sentence denotes Pygo1 homozygous null mice were viable and fertile with no developmental defects detectable.
T4097 6164-6169 NN denotes Pygo1
T4098 6181-6185 JJ denotes null
T4099 6170-6180 JJ denotes homozygous
T4100 6186-6190 NNS denotes mice
T4101 6191-6195 VBD denotes were
T4102 6196-6202 JJ denotes viable
T4103 6203-6206 CC denotes and
T4104 6207-6214 JJ denotes fertile
T4105 6215-6219 IN denotes with
T4106 6245-6255 JJ denotes detectable
T4107 6220-6222 DT denotes no
T4108 6237-6244 NNS denotes defects
T4109 6223-6236 JJ denotes developmental
T4110 6255-6256 . denotes .
T4111 6256-6550 sentence denotes This was surprising given the importance of the pygopus gene in Wnt signaling in Drosophila, and the reported expression during development of the mouse Pygo1 gene in, for example, the brain, limbs, kidney and branchial arches [14,16] (Yu J, Valerius MT, McMahon AP, contribution to GUDMAP, ).
T4112 6257-6261 DT denotes This
T4113 6262-6265 VBD denotes was
T4114 6266-6276 JJ denotes surprising
T4115 6277-6282 VBN denotes given
T4116 6283-6286 DT denotes the
T4117 6287-6297 NN denotes importance
T4118 6298-6300 IN denotes of
T4119 6301-6304 DT denotes the
T4120 6313-6317 NN denotes gene
T4121 6305-6312 NN denotes pygopus
T4122 6318-6320 IN denotes in
T4123 6321-6324 NN denotes Wnt
T4124 6325-6334 NN denotes signaling
T4125 6335-6337 IN denotes in
T4126 6338-6348 NNP denotes Drosophila
T4127 6348-6350 , denotes ,
T4128 6350-6353 CC denotes and
T4129 6354-6357 DT denotes the
T4130 6367-6377 NN denotes expression
T4131 6358-6366 VBN denotes reported
T4132 6378-6384 IN denotes during
T4133 6385-6396 NN denotes development
T4134 6397-6399 IN denotes of
T4135 6400-6403 DT denotes the
T4136 6416-6420 NN denotes gene
T4137 6404-6409 NN denotes mouse
T4138 6410-6415 NN denotes Pygo1
T4139 6421-6423 IN denotes in
T4140 6423-6425 , denotes ,
T4141 6425-6428 IN denotes for
T4142 6429-6436 NN denotes example
T4143 6436-6438 , denotes ,
T4144 6438-6441 DT denotes the
T4145 6442-6447 NN denotes brain
T4146 6447-6449 , denotes ,
T4147 6449-6454 NNS denotes limbs
T4148 6454-6456 , denotes ,
T4149 6456-6462 NN denotes kidney
T4150 6463-6466 CC denotes and
T4151 6467-6476 JJ denotes branchial
T4152 6477-6483 NNS denotes arches
T4153 6484-6485 -LRB- denotes [
T4154 6488-6490 CD denotes 16
T4155 6485-6487 CD denotes 14
T4156 6487-6488 , denotes ,
T4157 6490-6491 -RRB- denotes ]
T4158 6492-6493 -LRB- denotes (
T4159 6493-6495 NNP denotes Yu
T4160 6496-6497 NNP denotes J
T4161 6497-6499 , denotes ,
T4162 6499-6507 NNP denotes Valerius
T4163 6508-6510 NNP denotes MT
T4164 6510-6512 , denotes ,
T4165 6512-6519 NNP denotes McMahon
T4166 6520-6522 NNP denotes AP
T4167 6522-6524 , denotes ,
T4168 6524-6536 NN denotes contribution
T4169 6537-6539 IN denotes to
T4170 6540-6546 NN denotes GUDMAP
T4171 6546-6548 , denotes ,
T4172 6548-6549 -RRB- denotes )
T4173 6549-6550 . denotes .
T4174 6550-6651 sentence denotes The Pygo2 homozygous null mice survived to birth, but with rare exceptions, died shortly afterwards.
T4175 6551-6554 DT denotes The
T4176 6577-6581 NNS denotes mice
T4177 6555-6560 NN denotes Pygo2
T4178 6572-6576 JJ denotes null
T4179 6561-6571 JJ denotes homozygous
T4180 6582-6590 VBD denotes survived
T4181 6591-6593 IN denotes to
T4182 6594-6599 NN denotes birth
T4183 6599-6601 , denotes ,
T4184 6601-6604 CC denotes but
T4185 6605-6609 IN denotes with
T4186 6627-6631 VBD denotes died
T4187 6610-6614 JJ denotes rare
T4188 6615-6625 NNS denotes exceptions
T4189 6625-6627 , denotes ,
T4190 6632-6639 RB denotes shortly
T4191 6640-6650 RB denotes afterwards
T4192 6650-6651 . denotes .
T4193 6651-6780 sentence denotes The gut, heart and limbs developed without detectable abnormality (data not shown) despite known requirements for Wnt signaling.
T4194 6652-6655 DT denotes The
T4195 6656-6659 NN denotes gut
T4196 6677-6686 VBD denotes developed
T4197 6659-6661 , denotes ,
T4198 6661-6666 NN denotes heart
T4199 6667-6670 CC denotes and
T4200 6671-6676 NNS denotes limbs
T4201 6687-6694 IN denotes without
T4202 6695-6705 JJ denotes detectable
T4203 6706-6717 NN denotes abnormality
T4204 6718-6719 -LRB- denotes (
T4205 6728-6733 VBN denotes shown
T4206 6719-6723 NNS denotes data
T4207 6724-6727 RB denotes not
T4208 6733-6734 -RRB- denotes )
T4209 6735-6742 IN denotes despite
T4210 6743-6748 JJ denotes known
T4211 6749-6761 NNS denotes requirements
T4212 6762-6765 IN denotes for
T4213 6766-6769 NN denotes Wnt
T4214 6770-6779 NN denotes signaling
T4215 6779-6780 . denotes .
T4216 6780-6954 sentence denotes The Pygo2 mutants did, however, show growth retardation, lens agenesis and a kidney phenotype with high penetrance, exencephaly, and cleft palate with incomplete penetrance.
T4217 6781-6784 DT denotes The
T4218 6791-6798 NNS denotes mutants
T4219 6785-6790 NN denotes Pygo2
T4220 6813-6817 VB denotes show
T4221 6799-6802 VBD denotes did
T4222 6802-6804 , denotes ,
T4223 6804-6811 RB denotes however
T4224 6811-6813 , denotes ,
T4225 6818-6824 NN denotes growth
T4226 6825-6836 NN denotes retardation
T4227 6836-6838 , denotes ,
T4228 6838-6842 NN denotes lens
T4229 6843-6851 NN denotes agenesis
T4230 6852-6855 CC denotes and
T4231 6856-6857 DT denotes a
T4232 6865-6874 NN denotes phenotype
T4233 6858-6864 NN denotes kidney
T4234 6875-6879 IN denotes with
T4235 6880-6884 JJ denotes high
T4236 6885-6895 NN denotes penetrance
T4237 6895-6897 , denotes ,
T4238 6897-6908 NN denotes exencephaly
T4239 6908-6910 , denotes ,
T4240 6910-6913 CC denotes and
T4241 6914-6919 VBN denotes cleft
T4242 6920-6926 NN denotes palate
T4243 6927-6931 IN denotes with
T4244 6932-6942 JJ denotes incomplete
T4245 6943-6953 NN denotes penetrance
T4246 6953-6954 . denotes .
T4247 6954-7075 sentence denotes Double-homozygous mutant Pygo1 and Pygo2 mice had a phenotype similar to that of single Pygo2 nulls (Figure 1, Table 1).
T4248 6955-6961 JJ denotes Double
T4249 6962-6972 JJ denotes homozygous
T4250 6961-6962 HYPH denotes -
T4251 6996-7000 NNS denotes mice
T4252 6973-6979 NN denotes mutant
T4253 6980-6985 NN denotes Pygo1
T4254 6986-6989 CC denotes and
T4255 6990-6995 NN denotes Pygo2
T4256 7001-7004 VBD denotes had
T4257 7005-7006 DT denotes a
T4258 7007-7016 NN denotes phenotype
T4259 7017-7024 JJ denotes similar
T4260 7025-7027 IN denotes to
T4261 7028-7032 DT denotes that
T4262 7033-7035 IN denotes of
T4263 7036-7042 JJ denotes single
T4264 7049-7054 NNS denotes nulls
T4265 7043-7048 NN denotes Pygo2
T4266 7055-7056 -LRB- denotes (
T4267 7066-7071 NN denotes Table
T4268 7056-7062 NN denotes Figure
T4269 7063-7064 CD denotes 1
T4270 7064-7066 , denotes ,
T4271 7072-7073 CD denotes 1
T4272 7073-7074 -RRB- denotes )
T4273 7074-7075 . denotes .
T4274 7075-7164 sentence denotes There was no significant synergism of developmental abnormalities in the double mutants.
T4275 7076-7081 EX denotes There
T4276 7082-7085 VBD denotes was
T4277 7086-7088 DT denotes no
T4278 7101-7110 NN denotes synergism
T4279 7089-7100 JJ denotes significant
T4280 7111-7113 IN denotes of
T4281 7114-7127 JJ denotes developmental
T4282 7128-7141 NNS denotes abnormalities
T4283 7142-7144 IN denotes in
T4284 7145-7148 DT denotes the
T4285 7156-7163 NNS denotes mutants
T4286 7149-7155 JJ denotes double
T4287 7163-7164 . denotes .
T4288 7164-7335 sentence denotes Together these results suggest that Pygo2 is required for the proper development of a limited number of structures, whereas Pygo1 is not necessary for normal development.
T4289 7165-7173 RB denotes Together
T4290 7188-7195 VBP denotes suggest
T4291 7174-7179 DT denotes these
T4292 7180-7187 NNS denotes results
T4293 7196-7200 IN denotes that
T4294 7210-7218 VBN denotes required
T4295 7201-7206 NN denotes Pygo2
T4296 7207-7209 VBZ denotes is
T4297 7219-7222 IN denotes for
T4298 7223-7226 DT denotes the
T4299 7234-7245 NN denotes development
T4300 7227-7233 JJ denotes proper
T4301 7246-7248 IN denotes of
T4302 7249-7250 DT denotes a
T4303 7259-7265 NN denotes number
T4304 7251-7258 JJ denotes limited
T4305 7266-7268 IN denotes of
T4306 7269-7279 NNS denotes structures
T4307 7279-7281 , denotes ,
T4308 7281-7288 IN denotes whereas
T4309 7295-7297 VBZ denotes is
T4310 7289-7294 NN denotes Pygo1
T4311 7298-7301 RB denotes not
T4312 7302-7311 JJ denotes necessary
T4313 7312-7315 IN denotes for
T4314 7316-7322 JJ denotes normal
T4315 7323-7334 NN denotes development
T4316 7334-7335 . denotes .
T4763 8888-8889 . denotes .
T4762 8880-8888 NN denotes proteins
T6056 12603-12604 . denotes .
T6055 12602-12603 -RRB- denotes )
T6054 12596-12597 SYM denotes =
T6053 12594-12595 NN denotes P
T6052 12598-12602 CD denotes 0.33
T6051 12593-12594 -LRB- denotes (
T6050 12583-12584 SYM denotes +
T6049 12582-12583 HYPH denotes /
T6048 12581-12582 SYM denotes +
T6047 12576-12581 NN denotes Pygo2
T6046 12572-12575 CC denotes and
T6045 12570-12571 SYM denotes -
T6044 12569-12570 HYPH denotes /
T6043 12568-12569 SYM denotes +
T6042 12585-12592 NNS denotes embryos
T6041 12563-12568 NN denotes Pygo2
T6040 12555-12562 IN denotes between
T6039 12546-12549 VBD denotes was
T6038 12538-12545 NN denotes density
T6037 12533-12534 HYPH denotes -
T6036 12534-12537 NN denotes tip
T6035 12530-12533 NN denotes bud
T6034 12521-12529 JJ denotes ureteric
T6033 12518-12520 IN denotes in
T6032 12550-12554 VBN denotes seen
T6031 12495-12506 JJ denotes significant
T6030 12507-12517 NN denotes difference
T6029 12492-12494 DT denotes No
T6322 12631-12639 VBD denotes examined
T6321 12628-12630 PRP denotes We
T6320 12627-12686 sentence denotes We examined expression of three Wnt genes in Pygo mutants.
T6319 12614-12627 NN denotes hybridization
T6318 12609-12613 FW denotes situ
T6317 12606-12608 FW denotes In
T6434 13148-13149 . denotes .
T12215 24497-24498 SYM denotes -
T15863 32968-32971 CC denotes and
T17418 38073-38074 . denotes .
T18537 40106-40107 . denotes .
T18536 40102-40106 NN denotes E0.5
T18535 40087-40090 VBD denotes was
T18534 40073-40077 VBD denotes were
T18533 40067-40072 NNS denotes plugs
T18532 40059-40066 JJ denotes vaginal
T18531 40078-40086 VBN denotes observed
T18530 40054-40058 IN denotes that
T18529 40050-40053 NN denotes day
T18528 40046-40049 DT denotes the
T18527 40043-40045 IN denotes of
T18526 40091-40101 VBN denotes designated
T18525 40038-40042 NN denotes noon
T18524 40034-40037 DT denotes The
T19488 41436-41449 NN denotes hybridization
T19487 41431-41435 FW denotes situ
T19486 41428-41430 FW denotes In
T19111 40153-40158 VBN denotes fixed
T19110 40151-40153 , denotes ,
T19109 40137-40141 VBD denotes were
T19108 40142-40151 VBN denotes dissected
T19107 40129-40136 NNS denotes Kidneys
T19106 40128-40298 sentence denotes Kidneys were dissected, fixed in paraformaldehyde, treated with methanol, and washed with PBS containing Tween-20 (PBS-T) prior to treatment with lectins and antibodies.
T19105 40118-40128 NN denotes microscopy
T19104 40109-40117 JJ denotes Confocal
T19390 41425-41426 . denotes .
T19389 41411-41419 JJ denotes confocal
T19388 41420-41425 NN denotes image
T19387 41407-41410 DT denotes the
T19386 41404-41406 IN denotes of
T19385 41391-41398 VBN denotes defined
T19384 41399-41403 NN denotes area
T19383 41389-41390 DT denotes a
T19382 41382-41388 IN denotes within
T19381 41369-41373 VBD denotes were
T19380 41361-41368 NN denotes tracing
T19379 41353-41360 NN denotes section
T19378 41350-41352 IN denotes by
T19377 41339-41349 VBN denotes identified
T19376 41374-41381 VBN denotes counted
T19375 41334-41338 NNS denotes tips
T19374 41330-41333 NN denotes bud
T19373 41321-41329 JJ denotes Ureteric
T19372 41320-41426 sentence denotes Ureteric bud tips identified by section tracing were counted within a defined area of the confocal image.
T19371 41319-41320 . denotes .
T19370 41313-41319 NN denotes embryo
T19369 41308-41312 DT denotes each
T19368 41305-41307 IN denotes of
T19367 41293-41296 CD denotes two
T19366 41297-41304 NNS denotes kidneys
T19365 41289-41292 DT denotes the
T19364 41286-41288 IN denotes of
T19529 41639-41640 -RRB- denotes ]
T19528 41638-41639 CD denotes 2
T19527 41637-41638 -LRB- denotes [
T19526 41629-41636 NNP denotes Carroll
T19525 41626-41628 NNP denotes T.
T19524 41623-41625 IN denotes by
T19523 41610-41613 VBD denotes was
T19522 41614-41622 VBN denotes provided
T19521 41594-41599 NN denotes Wnt9b
T19520 41600-41609 NN denotes riboprobe
T19519 41590-41593 DT denotes The
T19518 41589-41641 sentence denotes The Wnt9b riboprobe was provided by T. Carroll [2].
T19517 41588-41589 . denotes .
T19516 41587-41588 -RRB- denotes ]
T19515 41585-41587 CD denotes 35
T19514 41584-41585 -LRB- denotes [
T19513 41573-41583 RB denotes previously
T19512 41558-41562 VBD denotes were
T19511 41552-41557 NN denotes Wnt7b
T19510 41548-41551 CC denotes and
T19509 41542-41547 NN denotes Wnt11
T19508 41539-41541 IN denotes to
T19507 41563-41572 VBN denotes described
T19506 41528-41538 NNS denotes Riboprobes
T19505 41527-41589 sentence denotes Riboprobes to Wnt11 and Wnt7b were described previously [35].
T19504 41526-41527 . denotes .
T19503 41525-41526 -RRB- denotes ]
T19502 41523-41525 CD denotes 35
T19501 41522-41523 -LRB- denotes [
T19500 41501-41511 RB denotes previously
T19499 41512-41521 VBN denotes described
T19498 41498-41500 IN denotes as
T19497 41484-41487 VBD denotes was
T19496 41488-41497 VBN denotes performed
T19495 41465-41469 FW denotes situ
T19494 41462-41464 FW denotes in
T19493 41470-41483 NN denotes hybridization
T19492 41455-41456 HYPH denotes -
T19491 41456-41461 NN denotes mount
T19490 41450-41455 JJ denotes Whole
T19489 41449-41527 sentence denotes Whole-mount in situ hybridization was performed as previously described [35].
T19530 41640-41641 . denotes .
T20785 43404-43409 NN denotes Pygo2
T20784 43402-43403 : denotes ;
T20783 43400-43401 SYM denotes -
T20782 43399-43400 HYPH denotes /
T20794 43427-43428 . denotes .
T20793 43419-43420 -RRB- denotes )
T20792 43416-43417 SYM denotes =
T20791 43414-43415 NN denotes n
T20790 43418-43419 CD denotes 6
T20789 43413-43414 -LRB- denotes (
T20788 43411-43412 SYM denotes -
T20787 43410-43411 HYPH denotes /
T20786 43409-43410 SYM denotes -
T20781 43398-43399 SYM denotes -
T20780 43393-43398 NN denotes Pygo1
T20779 43389-43392 CC denotes and
T20778 43387-43389 , denotes ,
T20777 43386-43387 -RRB- denotes )
T21397 44463-44464 . denotes .
T21396 44458-44462 IN denotes from
T21395 44444-44448 VBD denotes were
T21394 44449-44457 VBN denotes obtained
T21393 44431-44437 NN denotes target
T21392 44427-44430 NN denotes Wnt
T21391 44438-44443 NNS denotes genes
T21390 44417-44426 VBN denotes described
T21389 44406-44416 RB denotes Previously
T21388 44405-44464 sentence denotes Previously described Wnt target genes were obtained from .
T21387 44404-44405 . denotes .
T21386 44403-44404 -RRB- denotes )
T21385 44397-44398 SYM denotes <
T21383 44391-44396 NN denotes value
T21865 44566-44573 NNS denotes kidneys
T21864 44531-44536 NN denotes E18.5
T21863 44526-44530 IN denotes from
T21862 44668-44676 VBN denotes purified
T21861 44522-44525 NN denotes RNA
T21860 44516-44521 JJ denotes Total
T21859 44515-44788 sentence denotes Total RNA from E18.5 Pygo1/Pygo2 null and control kidneys (both represented in duplicate and distinct from the kidneys used for microrray analysis) was purified using a commercial kit (Absolutely RNA Microprep Kit; Stratagene, La Jolla, CA USA) including DNAse1 treatment.
T21858 44508-44515 NNS denotes results
T21857 44497-44507 NN denotes microarray
T21856 44494-44496 IN denotes of
T21855 44479-44482 NN denotes PCR
T21854 44483-44493 NN denotes validation
T21853 44466-44478 JJ denotes Quantitative
T22081 45881-45887 NN denotes method
T22080 45856-45859 DT denotes the
T22095 45892-45893 . denotes .
T22094 45891-45892 -RRB- denotes ]
T22093 45889-45891 CD denotes 38
T22092 45888-45889 -LRB- denotes [
T22091 45879-45880 -RRB- denotes )
T22090 45878-45879 -RRB- denotes )
T22089 45876-45877 -LRB- denotes (
T22088 45875-45876 NN denotes C
T22087 45869-45874 NN denotes Delta
T22086 45863-45868 NN denotes Delta
T22085 45862-45863 HYPH denotes -
T22084 45861-45862 -LRB- denotes (
T22083 45877-45878 NN denotes T
T22082 45860-45861 CD denotes 2
T22079 45850-45855 VBG denotes using
T22078 45841-45849 VBN denotes analyzed
T22077 45837-45840 CC denotes and
T22076 45835-45836 -RRB- denotes )
T22293 7346-7351 NN denotes Pygo1
T22294 7352-7357 NN denotes Pygo2
T22295 7351-7352 HYPH denotes /
T22296 7358-7364 NN denotes mutant
T22297 7365-7372 NNS denotes embryos
T22298 7372-7373 . denotes .
T22299 7373-7465 sentence denotes (A) E18.5 Pygo1-/-/Pygo2+/- embryos, with only one wild-type Pygo2 allele, appeared normal.
T22300 7374-7375 -LRB- denotes (
T22301 7375-7376 LS denotes A
T22302 7449-7457 VBD denotes appeared
T22303 7376-7377 -RRB- denotes )
T22304 7378-7383 NN denotes E18.5
T22305 7402-7409 NNS denotes embryos
T22306 7384-7389 NN denotes Pygo1
T22307 7389-7390 SYM denotes -
T22308 7390-7391 HYPH denotes /
T22309 7391-7392 SYM denotes -
T22310 7392-7393 HYPH denotes /
T22311 7393-7398 NN denotes Pygo2
T22312 7398-7399 SYM denotes +
T22313 7399-7400 HYPH denotes /
T22314 7400-7401 SYM denotes -
T22315 7409-7411 , denotes ,
T22316 7411-7415 IN denotes with
T22317 7416-7420 RB denotes only
T22318 7441-7447 NN denotes allele
T22319 7421-7424 CD denotes one
T22320 7425-7429 JJ denotes wild
T22321 7430-7434 NN denotes type
T22322 7429-7430 HYPH denotes -
T22323 7435-7440 NN denotes Pygo2
T22324 7447-7449 , denotes ,
T22325 7458-7464 JJ denotes normal
T22326 7464-7465 . denotes .
T22327 7465-7629 sentence denotes (B, C) Double homozygous mutant Pygo1-/-/Pygo2-/- embryos were smaller, with eye defects including absent or rudimentary lens and folded pigmented retina (arrows).
T22328 7466-7467 -LRB- denotes (
T22329 7467-7468 LS denotes B
T22330 7524-7528 VBD denotes were
T22331 7468-7470 , denotes ,
T22332 7470-7471 LS denotes C
T22333 7471-7472 -RRB- denotes )
T22334 7473-7479 JJ denotes Double
T22335 7480-7490 JJ denotes homozygous
T22336 7491-7497 NN denotes mutant
T22337 7516-7523 NNS denotes embryos
T22338 7498-7503 NN denotes Pygo1
T22339 7503-7504 SYM denotes -
T22340 7504-7505 HYPH denotes /
T22341 7505-7506 SYM denotes -
T22342 7506-7507 HYPH denotes /
T22343 7507-7512 NN denotes Pygo2
T22344 7512-7513 SYM denotes -
T22345 7513-7514 HYPH denotes /
T22346 7514-7515 SYM denotes -
T22347 7529-7536 JJR denotes smaller
T22348 7536-7538 , denotes ,
T22349 7538-7542 IN denotes with
T22350 7543-7546 NN denotes eye
T22351 7547-7554 NNS denotes defects
T22352 7555-7564 VBG denotes including
T22353 7565-7571 JJ denotes absent
T22354 7587-7591 NN denotes lens
T22355 7572-7574 CC denotes or
T22356 7575-7586 JJ denotes rudimentary
T22357 7592-7595 CC denotes and
T22358 7596-7602 VBN denotes folded
T22359 7613-7619 NN denotes retina
T22360 7603-7612 VBN denotes pigmented
T22361 7620-7621 -LRB- denotes (
T22362 7621-7627 NNS denotes arrows
T22363 7627-7628 -RRB- denotes )
T22364 7628-7629 . denotes .
T22365 7629-7708 sentence denotes (C) A small percentage of Pygo1/Pygo2 null embryos also displayed exencephaly.
T22366 7630-7631 -LRB- denotes (
T22367 7631-7632 LS denotes C
T22368 7686-7695 VBD denotes displayed
T22369 7632-7633 -RRB- denotes )
T22370 7634-7635 DT denotes A
T22371 7642-7652 NN denotes percentage
T22372 7636-7641 JJ denotes small
T22373 7653-7655 IN denotes of
T22374 7656-7661 NN denotes Pygo1
T22375 7662-7667 NN denotes Pygo2
T22376 7661-7662 HYPH denotes /
T22377 7668-7672 JJ denotes null
T22378 7673-7680 NNS denotes embryos
T22379 7681-7685 RB denotes also
T22380 7696-7707 NN denotes exencephaly
T22381 7707-7708 . denotes .
T22742 9464-9465 . denotes .
T22741 9459-9460 SYM denotes ×
T22676 9109-9112 JJ denotes red
T22675 9108-9109 -LRB- denotes (
T22674 9102-9107 NN denotes Pygo2
T22673 9098-9101 CC denotes and
T22672 9119-9128 VBN denotes localized
T22671 9092-9097 NN denotes Pygo1
T22670 9087-9091 CC denotes Both
T22669 9086-9157 sentence denotes Both Pygo1 and Pygo2 (red) were localized in the nucleus, as expected.
T22740 9461-9464 CD denotes 200
T22739 9445-9458 NN denotes magnification
T22738 9436-9444 JJ denotes Original
T22737 9435-9465 sentence denotes Original magnification × 200.
T22736 9434-9435 . denotes .
T22735 9426-9434 NN denotes antibody
T22734 9416-9417 HYPH denotes -
T22733 9417-9425 NN denotes cadherin
T22732 9415-9416 NN denotes E
T22731 9409-9414 VBG denotes using
T23300 11087-11088 . denotes .
T23299 11082-11083 SYM denotes ×
T23298 11084-11087 CD denotes 200
T23297 11068-11081 NN denotes magnification
T23296 11059-11067 JJ denotes Original
T23295 11058-11088 sentence denotes Original magnification × 200.
T23294 11057-11058 . denotes .
T23293 11050-11057 NNS denotes mutants
T23589 13262-13264 IN denotes of
T23588 13257-13261 FW denotes situ
T23587 13254-13256 FW denotes in
T23586 13247-13248 HYPH denotes -
T23585 13248-13253 NN denotes mount
T23584 13242-13247 JJ denotes Whole
T23583 13241-13443 sentence denotes Whole-mount in situ of hybridizations of (A-C) E18.5 wild-type kidneys and (D-F) Pygo1-/-/Pygo2-/- mutant kidneys with the ureteric bud derivative markers: (A, D) Wnt7b, (B, E) Wnt9b, and (C, F) Wnt11.
T23582 13240-13241 . denotes .
T23581 13219-13227 NN denotes compound
T23580 13228-13232 JJ denotes null
T23579 13212-13213 HYPH denotes /
T23578 13213-13218 NN denotes Pygo2
T24395 14967-14970 NN denotes gal
T24499 15401-15402 . denotes .
T26401 17832-17833 . denotes .
T26632 18516-18517 . denotes .
T26631 18510-18511 SYM denotes ×
T26630 18508-18509 -RRB- denotes )
T26629 18512-18516 CD denotes 12.5
T26628 18507-18508 NN denotes O
T26627 18506-18507 -LRB- denotes (
T26626 18502-18505 CC denotes and
T26625 18500-18502 , denotes ,
T26624 18496-18497 SYM denotes ×
T26623 18494-18495 -RRB- denotes )
T26622 18498-18500 CD denotes 10
T26621 18491-18493 , denotes ,
T26620 18490-18491 NN denotes M
T26619 18493-18494 NN denotes N
T26618 18489-18490 -LRB- denotes (
T26617 18487-18489 , denotes ,
T26616 18483-18484 SYM denotes ×
T27042 22275-22276 . denotes .
T27041 22265-22270 RBS denotes least
T27040 22271-22275 CD denotes four
T27039 22262-22264 RB denotes at
T27038 22259-22261 IN denotes of
T27037 22247-22253 NN denotes sample
T27036 22254-22258 NN denotes size
T27035 22245-22246 DT denotes a
T27034 22236-22244 VBD denotes included
T27033 22217-22229 JJ denotes experimental
T27032 22230-22235 NN denotes group
T27031 22212-22216 DT denotes Each
T27030 22211-22276 sentence denotes Each experimental group included a sample size of at least four.
T27029 22210-22211 . denotes .
T27028 22197-22202 NN denotes Pygo1
T27027 22203-22210 NNS denotes alleles
T27026 22191-22192 HYPH denotes -
T27025 22192-22196 NN denotes type
T27024 22187-22191 JJ denotes wild
T27023 22179-22186 IN denotes without
T27022 22176-22178 CC denotes or
T27021 22171-22175 IN denotes with
T27020 22169-22171 , denotes ,
T27019 22166-22169 JJ denotes low
T27018 22156-22165 RB denotes uniformly
T27017 22141-22151 NN denotes expression
T27016 22136-22137 HYPH denotes -
T27015 22137-22140 NN denotes gal
T27014 22133-22136 NN denotes BAT
T27013 22125-22132 NNS denotes mutants
T27012 22114-22124 JJ denotes homozygous
T27011 22108-22113 NN denotes Pygo2
T27010 22152-22155 VBD denotes was
T27009 22105-22107 IN denotes In
T27008 22104-22211 sentence denotes In Pygo2 homozygous mutants BAT-gal expression was uniformly low, with or without wild-type Pygo1 alleles.
T27315 28754-28758 IN denotes from
T27314 28740-28744 VBD denotes were
T27313 28745-28753 VBN denotes selected
T27312 28728-28731 NN denotes Wnt
T27311 28732-28739 NNS denotes targets
T27423 7718-7728 NNS denotes Phenotypes
T27424 7729-7731 IN denotes of
T27425 7732-7737 NN denotes Pygo2
T27426 7743-7747 NN denotes type
T27427 7738-7742 JJ denotes wild
T27428 7742-7743 HYPH denotes -
T27429 7779-7786 NNS denotes embryos
T27430 7747-7749 , denotes ,
T27431 7749-7762 JJ denotes heterozyogous
T27432 7762-7764 , denotes ,
T27433 7764-7767 CC denotes and
T27434 7768-7772 JJ denotes null
T27435 7773-7778 NN denotes E18.5
T27436 7787-7789 IN denotes on
T27437 7790-7791 DT denotes a
T27438 7803-7813 NN denotes background
T27439 7792-7797 NN denotes Pygo1
T27440 7798-7802 JJ denotes null
T27441 7813-7814 . denotes .
T27377 29077-29078 . denotes .
T27376 29071-29077 NNS denotes levels
T27375 29060-29070 NN denotes expression
T27374 29057-29059 IN denotes in
T27373 29049-29056 NNS denotes changes
T27372 29037-29048 JJ denotes significant
T27506 11735-11736 . denotes .
T27505 11720-11724 JJ denotes null
T27504 11714-11719 NN denotes Pygo1
T27503 11725-11735 NN denotes background
T27502 11710-11713 DT denotes the
T27501 11707-11709 IN denotes on
T27500 11693-11698 NN denotes E18.5
T27499 11688-11692 JJ denotes null
T27498 11684-11687 CC denotes and
T27497 11682-11684 , denotes ,
T27496 11670-11682 JJ denotes heterozygous
T27495 11668-11670 , denotes ,
T27494 11699-11706 NNS denotes kidneys
T27493 11663-11664 HYPH denotes -
T27492 11659-11663 JJ denotes wild
T27491 11664-11668 NN denotes type
T27490 11653-11658 NN denotes Pygo2
T27489 11650-11652 IN denotes of
T27488 11641-11649 NN denotes analysis
T27487 11632-11640 JJ denotes Confocal
T27661 29539-29542 DT denotes the
T27660 29536-29538 IN denotes in
T27659 29528-29535 NNS denotes changes
T27658 29517-29527 NN denotes expression
T27657 29512-29516 NN denotes gene
T27656 29509-29511 IN denotes of
T27655 29498-29508 NN denotes Validation
T27599 25117-25118 . denotes .
T27598 25110-25117 NNS denotes samples
T27597 25104-25105 HYPH denotes -
T27596 25105-25109 NN denotes type
T27595 25100-25104 JJ denotes wild
T27594 25097-25099 IN denotes to
T27593 25086-25096 VBN denotes normalized
T27592 25073-25078 NN denotes E18.5
T27591 25068-25072 JJ denotes null
T27590 25061-25062 HYPH denotes /
T27675 29611-29612 . denotes .
T27674 29598-29599 HYPH denotes -
T27673 29599-29603 NN denotes type
T27672 29594-29598 JJ denotes wild
T27671 29604-29611 NNS denotes kidneys
T27670 29588-29593 NN denotes E18.5
T27669 29585-29587 IN denotes to
T27668 29574-29584 VBN denotes normalized
T27667 29561-29565 JJ denotes null
T27666 29554-29555 HYPH denotes /
T27665 29555-29560 NN denotes Pygo2
T27664 29549-29554 NN denotes Pygo1
T27663 29543-29548 NN denotes E18.5
T27662 29566-29573 NNS denotes kidneys
T12301 24916-24917 DT denotes a
T12300 24905-24910 MD denotes might
T12299 24892-24893 HYPH denotes /
T12298 24893-24898 NN denotes Pygo2
T12297 24887-24892 NN denotes Pygo1
T12296 24899-24904 NNS denotes genes
T12295 24883-24886 DT denotes the
T12294 24911-24915 VB denotes play
T12293 24878-24882 IN denotes that
T12292 24870-24877 VBP denotes suggest
T12291 24862-24869 NNS denotes results
T12290 24856-24861 DT denotes These
T12289 24855-24969 sentence denotes These results suggest that the Pygo1/Pygo2 genes might play a role in nephron maturation and subsequent function.
T12288 24854-24855 . denotes .
T12596 28431-28433 IN denotes of
T12595 28420-28430 NN denotes expression
T12594 28417-28419 IN denotes in
T12593 28409-28416 NNS denotes changes
T12592 28400-28408 JJ denotes dramatic
T12591 28397-28399 IN denotes of
T12590 28389-28396 NN denotes absence
T12589 28386-28388 DT denotes an
T12588 28377-28385 VBP denotes indicate
T12587 28369-28376 NNS denotes results
T12586 28363-28368 DT denotes These
T12585 28362-28512 sentence denotes These results indicate an absence of dramatic changes in expression of previously known Wnt signaling target genes in the Pygo1/Pygo2 mutant kidneys.
T12584 28361-28362 . denotes .
T12583 28354-28361 NNS denotes kidneys
T12582 28349-28353 JJ denotes null
T12581 28342-28343 HYPH denotes /
T12580 28343-28348 NN denotes Pygo2
T12579 28337-28342 NN denotes Pygo1
T12578 28334-28336 IN denotes in
T12577 28325-28333 RB denotes 1.5-fold
T12576 28324-28325 SYM denotes <
T12575 28321-28323 IN denotes of
T12574 28313-28320 NNS denotes changes
T12573 28307-28312 NN denotes level
T12572 28296-28306 NN denotes expression
T12614 29087-29099 JJ denotes quantitative
T12613 29082-29086 VBD denotes used
T12612 29079-29081 PRP denotes We
T12611 28512-29187 sentence denotes Figure 8 Gene expression changes of common Wnt signaling targets in the E18.5 Pygo1/Pygo2 null kidney. Microarray analysis was performed in triplicate on wild-type and Pygo1/2 compound null E18.5 kidneys. Possible Wnt targets were selected from those compiled at [39]. An initial gene list of 82 Wnt targets was created and then reduced to a total of 40 genes using an expression level restriction requiring the raw expression intensity to be >100 in at least 3 samples. Pygo1 and Pygo2 probes were included to demonstrate significant changes in expression levels. We used quantitative real-time PCR, with independent biological samples, to validate the microarray results.
T12651 29289-29298 VBN denotes predicted
T12650 29274-29278 JJ denotes same
T9423 14147-14154 VBP denotes suggest
T9422 14139-14146 NNS denotes results
T9421 14133-14138 DT denotes These
T9420 14132-14282 sentence denotes These results suggest that the mammalian Pygo genes are significant modulators of canonical Wnt signaling in some, but not in all developing systems.
T9419 14131-14132 . denotes .
T9418 14118-14121 NN denotes Wnt
T9417 14122-14131 NN denotes signaling
T9416 14111-14117 JJ denotes robust
T9415 14098-14103 RB denotes still
T9414 14077-14083 NN denotes mutant
T9413 14084-14097 NN denotes telencephalon
T9412 14073-14076 DT denotes the
T9411 14104-14110 VBD denotes showed
T9410 14067-14072 IN denotes while
T5730 9886-9892 IN denotes around
T5729 9863-9874 JJ denotes metanephric
T5728 9855-9862 VBG denotes capping
T5727 9875-9885 NN denotes mesenchyme
T5726 9851-9854 DT denotes the
T5725 9840-9844 DT denotes both
T5724 9845-9850 VBP denotes stain
T5723 9827-9828 -RRB- denotes )
T5722 9824-9827 NN denotes red
T5721 9823-9824 -LRB- denotes (
T5720 9816-9822 NN denotes Cited1
T5823 11104-11111 sentence denotes (red) s
T5822 11103-11104 sentence denotes
T5821 11102-11103 CD denotes 1
T5820 11101-11102 CC denotes d
T5819 11098-11101 NNS denotes ite
T5818 11097-11098 NN denotes C
T5817 11095-11096 CC denotes d
T5816 11093-11095 JJ denotes an
T5815 11092-11093 , denotes
T5814 11089-11092 NN denotes Wt1
T5813 11089-11103 sentence denotes Wt1 and Cited1
T5864 11260-11261 . denotes .
T5863 11259-11260 -RRB- denotes )
T5862 11258-11259 CD denotes 2
T5861 11250-11252 , denotes ,
T5860 11249-11250 CD denotes 3
T5859 11242-11248 NN denotes Figure
T5858 11252-11257 NN denotes Table
T5857 11241-11242 -LRB- denotes (
T5856 11227-11235 JJ denotes ureteric
T5855 11220-11226 NN denotes mutant
T5854 11236-11240 NNS denotes buds
T5853 11216-11219 DT denotes the
T5852 11204-11215 VBG denotes surrounding
T5851 11185-11192 VBG denotes capping
T5850 11193-11203 NN denotes mesenchyme
T5849 11181-11184 DT denotes the
T5848 11178-11180 IN denotes of
T5847 11168-11177 NN denotes thickness
T5846 11164-11167 DT denotes the
T5845 11161-11163 IN denotes in
T5844 11159-11160 NN denotes %
T5843 11157-11159 CD denotes 30
T5842 11143-11156 RB denotes approximately
T5841 11140-11142 IN denotes of
T5840 11131-11139 NN denotes increase
T5839 11128-11130 DT denotes an
T5838 11121-11127 VBD denotes vealed
T5837 11121-11261 sentence denotes vealed an increase of approximately 30% in the thickness of the capping mesenchyme surrounding the mutant ureteric buds (Figure 3, Table 2).
T5836 11119-11121 JJ denotes re
T5835 11117-11118 VBG denotes g
T5834 11117-11121 sentence denotes g re
T5833 11116-11117 NNS denotes n
T5832 11115-11116 IN denotes i
T5831 11113-11115 IN denotes in
T5830 11112-11113 JJ denotes a
T5829 11111-11112 NN denotes t
T5828 11111-11117 sentence denotes tainin
T5827 11108-11109 -RRB- denotes )
T5826 11110-11111 NNS denotes s
T5825 11105-11108 VBN denotes red
T5824 11104-11105 -LRB- denotes (
T5866 11262-11274 RB denotes Nevertheless
T5865 11261-11352 sentence denotes Nevertheless, the mutant metanephric mesenchyme underwent relatively normal nephrogenesis.
T5892 11426-11429 NN denotes bud
T5891 11417-11425 JJ denotes ureteric
T5890 11430-11434 NNS denotes tips
T5889 11413-11416 DT denotes the
T5888 11410-11412 IN denotes to
T5887 11399-11409 VBG denotes connecting
T5886 11383-11387 VBD denotes were
T5885 11381-11382 -RRB- denotes )
T5884 11377-11381 NN denotes blue
T5883 11376-11377 -LRB- denotes (
T5882 11388-11398 VBN denotes identified
T5881 11367-11375 NNS denotes nephrons
T5880 11357-11358 HYPH denotes -
T5879 11358-11366 VBG denotes staining
T5878 11353-11357 NN denotes Cdh1
T5877 11352-11496 sentence denotes Cdh1-staining nephrons (blue) were identified connecting to the ureteric bud tips [16] and extending into the medulla of the kidney, as normal.
T5876 11351-11352 . denotes .
T5875 11338-11351 NN denotes nephrogenesis
T5874 11331-11337 JJ denotes normal
T5873 11320-11330 RB denotes relatively
T5872 11287-11298 JJ denotes metanephric
T5871 11280-11286 NN denotes mutant
T5870 11299-11309 NN denotes mesenchyme
T5869 11276-11279 DT denotes the
T5868 11274-11276 , denotes ,
T5867 11310-11319 VBD denotes underwent
T5950 12119-12121 CD denotes 16
T5949 12118-12119 -LRB- denotes [
T5948 12109-12112 NN denotes bud
T5947 12100-12108 JJ denotes ureteric
T5946 12113-12117 NNS denotes tips
T5945 12096-12099 DT denotes the
T5944 12151-12155 VBD denotes were
T5943 12091-12095 IN denotes that
T5942 12085-12090 VBD denotes howed
T5941 12085-12265 sentence denotes howed that the ureteric bud tips [16] of Pygo1/Pygo2 null kidneys were dilated and misshaped compared with those of littermates with at least one wild-type Pygo2 allele (Figure 3).
T943 16-21 NNS denotes roles
T12316 27019-27021 IN denotes in
T12315 27007-27018 VBN denotes upregulated
T12314 27050-27058 VBN denotes included
T12313 27001-27006 NNS denotes genes
T12312 26990-27000 JJ denotes Noteworthy
T12311 26990-27134 sentence denotes Noteworthy genes upregulated in the Pygo1/Pygo2 null kidney included Klk5 (2.8-fold), Klk6 (2.7-fold), Ren2 (2.2-fold), and Timeless (2.4-fold).
T12310 24969-24970 sentence denotes
T12309 24968-24969 . denotes .
T12308 24960-24968 NN denotes function
T12307 24949-24959 JJ denotes subsequent
T12306 24945-24948 CC denotes and
T12305 24934-24944 NN denotes maturation
T12304 24926-24933 NN denotes nephron
T12303 24923-24925 IN denotes in
T12302 24918-24922 NN denotes role
T12362 27220-27231 NNS denotes Kallikreins
T12610 28511-28512 . denotes .
T12609 28497-28503 NN denotes mutant
T12608 28490-28491 HYPH denotes /
T12607 28491-28496 NN denotes Pygo2
T12606 28485-28490 NN denotes Pygo1
T12605 28504-28511 NNS denotes kidneys
T12604 28481-28484 DT denotes the
T12603 28478-28480 IN denotes in
T12602 28465-28471 NN denotes target
T12601 28455-28464 NN denotes signaling
T12600 28451-28454 NN denotes Wnt
T12599 28472-28477 NNS denotes genes
T12598 28445-28450 VBN denotes known
T12597 28434-28444 RB denotes previously
T12649 29279-29288 NN denotes direction
T12648 29270-29273 DT denotes the
T12647 29267-29269 IN denotes in
T12646 29255-29259 NN denotes fold
T12645 29243-29254 JJ denotes significant
T12644 29260-29266 NN denotes change
T12643 29241-29242 DT denotes a
T12642 29229-29232 VBD denotes did
T12641 29226-29228 PRP denotes we
T12640 29220-29225 CD denotes seven
T12639 29233-29240 VB denotes observe
T12638 29216-29219 IN denotes for
T12637 29212-29215 CC denotes and
T12636 29210-29212 , denotes ,
T12635 29199-29203 VBD denotes were
T12634 29204-29210 VBN denotes tested
T12633 29193-29198 NNS denotes genes
T12632 29188-29192 CD denotes Nine
T12631 29187-29335 sentence denotes Nine genes were tested, and for seven we did observe a significant fold change in the same direction predicted by the microarray results (Table 4).
T12630 29186-29187 . denotes .
T12629 29168-29178 NN denotes microarray
T12628 29179-29186 NNS denotes results
T12627 29164-29167 DT denotes the
T12626 29155-29163 VB denotes validate
T12625 29152-29154 TO denotes to
T12624 29150-29152 , denotes ,
T12623 29132-29142 JJ denotes biological
T12622 29143-29150 NNS denotes samples
T12621 29120-29131 JJ denotes independent
T12620 29115-29119 IN denotes with
T12619 29113-29115 , denotes ,
T12618 29104-29105 HYPH denotes -
T12617 29105-29109 NN denotes time
T12616 29100-29104 JJ denotes real
T12615 29110-29113 NN denotes PCR
T9455 15411-15412 NNS denotes e
T9454 15411-15412 sentence denotes e
T9453 15408-15409 NN denotes s
T9452 15409-15410 NN denotes o
T9451 15406-15408 DT denotes al
T9450 15405-15411 sentence denotes also
T9449 15404-15405 NNS denotes e
T9448 15403-15404 NN denotes W
T9447 15403-15405 sentence denotes We
T9446 14282-14283 sentence denotes
T9445 14281-14282 . denotes .
T9444 14274-14281 NNS denotes systems
T9443 14263-14273 VBG denotes developing
T9442 14259-14262 DT denotes all
T9441 14256-14258 IN denotes in
T9440 14252-14255 RB denotes not
T9439 14248-14251 CC denotes but
T9438 14246-14248 , denotes ,
T9437 14242-14246 DT denotes some
T9436 14239-14241 IN denotes in
T9435 14225-14228 NN denotes Wnt
T9434 14229-14238 NN denotes signaling
T9433 14215-14224 JJ denotes canonical
T9432 14212-14214 IN denotes of
T9431 14201-14211 NNS denotes modulators
T9430 14189-14200 JJ denotes significant
T9429 14174-14178 NN denotes Pygo
T9428 14164-14173 JJ denotes mammalian
T9427 14179-14184 NNS denotes genes
T9426 14160-14163 DT denotes the
T9425 14185-14188 VBP denotes are
T9424 14155-14159 IN denotes that
T9468 15430-15434 sentence denotes port
T9467 15423-15424 HYPH denotes -
T9466 15424-15427 NN denotes gal
T9465 15420-15423 NN denotes BAT
T9464 15428-15430 NN denotes re
T9463 15418-15419 JJ denotes d
T9462 15417-15418 NNS denotes e
T9461 15416-15417 NN denotes n
T9460 15416-15430 sentence denotes ned BAT-gal re
T9459 15414-15416 NNS denotes mi
T9458 15413-15414 JJ denotes a
T9457 15412-15413 NN denotes x
T9456 15412-15416 sentence denotes xami
T9484 15466-15469 DT denotes the
T9483 15463-15465 IN denotes in
T9482 15456-15462 NN denotes detail
T9481 15451-15455 JJR denotes more
T9480 15448-15450 IN denotes in
T9479 15442-15447 NN denotes ssion
T9478 15439-15442 NN denotes pre
T9477 15438-15439 VBD denotes x
T9476 15438-15515 sentence denotes xpression in more detail in the developing urogenital system of Pygo mutants.
T9475 15437-15438 DT denotes e
T9474 15434-15435 NNS denotes e
T9473 15435-15436 VBD denotes r
T9472 15434-15438 sentence denotes er e
T9471 15433-15434 NN denotes t
T9470 15432-15433 JJ denotes r
T9469 15430-15432 NN denotes po
T9605 18530-18531 VB denotes e
T9604 18530-18539 sentence denotes e Pygo2 g
T9603 18529-18530 JJ denotes h
T9602 18528-18529 JJ denotes t
T9601 18528-18530 sentence denotes th
T9600 18526-18528 , denotes ,
T9599 18523-18526 NN denotes 3.5
T9598 18521-18523 NN denotes E1
T9597 18521-18528 sentence denotes E13.5,
T9596 18519-18520 NN denotes t
T9595 18518-18519 NN denotes A
T9594 18518-18521 sentence denotes At
T9593 16000-16001 sentence denotes
T9592 15999-16000 . denotes .
T9591 15998-15999 -RRB- denotes )
T9620 18554-18555 sentence denotes
T9619 18553-18554 NN denotes o
T9618 18552-18553 DT denotes t
T9617 18548-18551 VBN denotes red
T9616 18547-18548 CC denotes a
T9615 18545-18547 NN denotes pe
T9614 18544-18545 NN denotes p
T9613 18544-18554 sentence denotes ppeared to
T9612 18543-18544 JJ denotes a
T9611 18541-18542 DT denotes e
T9610 18540-18541 IN denotes n
T9609 18539-18540 NN denotes e
T9608 18539-18544 sentence denotes ene a
T9607 18538-18539 JJ denotes g
T9606 18532-18537 NN denotes Pygo2
T9629 18562-18564 NN denotes ma
T9628 18560-18561 JJ denotes a
T9627 18559-18560 , denotes
T9626 18558-18559 NN denotes y
T9625 18558-18564 sentence denotes y a ma
T9624 18557-18558 CC denotes a
T9623 18556-18557 VBG denotes l
T9622 18555-18556 NN denotes p
T9621 18555-18558 sentence denotes pla
T9642 18607-18609 IN denotes in
T9641 18605-18607 , denotes ,
T9631 18568-18572 NN denotes role
T9630 18564-18690 sentence denotes jor role, and the Pygo1 gene a minor role, in canonical Wnt signaling in the ureteric tree, as measured by BAT-gal expression.
T9640 18595-18600 JJ denotes minor
T9639 18593-18594 DT denotes a
T9638 18601-18605 NN denotes role
T9637 18582-18587 NN denotes Pygo1
T9636 18588-18592 NN denotes gene
T9635 18578-18581 DT denotes the
T9634 18574-18577 CC denotes and
T9633 18572-18574 , denotes ,
T9632 18564-18567 JJ denotes jor
T10289 21326-21328 , denotes ,
T10288 21318-21319 SYM denotes -
T10287 21317-21318 HYPH denotes /
T10286 21316-21317 SYM denotes +
T10285 21311-21316 NN denotes Pygo2
T10284 21310-21311 HYPH denotes /
T10283 21309-21310 SYM denotes -
T10282 21308-21309 HYPH denotes /
T10281 21307-21308 SYM denotes -
T10280 21302-21307 NN denotes Pygo1
T10279 21296-21301 NN denotes E18.5
T10278 21320-21326 NN denotes kidney
T10277 21292-21295 DT denotes the
T10276 21289-21291 IN denotes in
T10275 21376-21384 VBD denotes revealed
T10274 21275-21278 VBD denotes was
T10273 21264-21274 NN denotes expression
T10366 22299-22301 , denotes ,
T10365 22292-22299 RB denotes however
T10364 22290-22292 , denotes ,
T10363 22345-22351 VBD denotes showed
T10362 22277-22290 RB denotes Interestingly
T10361 21706-22518 sentence denotes Figure 7 Quantitative analysis of BAT-gal reporter expression in Pygo1/Pygo2 E18.5 kidney extracts. Transgene-specific beta-galactosidase was quantified by ELISA analysis. Pygo1+/-/Pygo2+/+, Pygo1+/-/Pygo2+/- and Pygo1+/-/Pygo2+/+ kidneys all showed similar levels of BAT-gal expression. In the Pygo2 hetereozygote, Pygo1 homozygous mutants, however, reporter expression was reduced by about 50%. In Pygo2 homozygous mutants BAT-gal expression was uniformly low, with or without wild-type Pygo1 alleles. Each experimental group included a sample size of at least four. Interestingly, however, even in wild-type mice the BAT-gal reporter showed no expression in the developing metanephric mesenchyme, or metanephric mesenchyme-derived structures, such as renal vesicles, S-shaped bodies, tubules, and glomeruli.
T16446 36293-36446 sentence denotes We would predict these genes to show greater changes in expression level in a developing kidney with a more complete removal of canonical Wnt signaling.
T16445 36292-36293 . denotes .
T16444 36281-36292 NN denotes development
T16443 36274-36280 NN denotes kidney
T16442 36271-36273 IN denotes in
T16441 36269-36270 -RRB- denotes )
T16440 36261-36269 JJ denotes indirect
T16439 36258-36260 CC denotes or
T16438 36251-36257 JJ denotes direct
T16437 36250-36251 -LRB- denotes (
T16436 36238-36241 NN denotes Wnt
T16435 36242-36249 NNS denotes targets
T16434 36228-36237 NN denotes candidate
T16433 36206-36217 NNS denotes differences
T16432 36195-36205 NN denotes expression
T16431 36190-36194 IN denotes with
T16430 36184-36189 NNS denotes genes
T16429 36180-36183 DT denotes the
T16428 36178-36180 , denotes ,
T16427 36168-36178 NNP denotes Drosophila
T16426 36165-36167 IN denotes in
T16425 36148-36158 RB denotes previously
T16424 36143-36147 VBN denotes been
T16423 36139-36142 VBZ denotes has
T16422 36159-36164 VBN denotes shown
T16421 36136-36138 IN denotes as
T16420 36134-36136 , denotes ,
T16419 36121-36124 NN denotes Wnt
T16418 36125-36134 NN denotes signaling
T16417 36111-36120 JJ denotes canonical
R7 T946 T943 prep in,roles
R8 T947 T948 compound Wnt,signaling
R9 T948 T946 pobj signaling,in
R10 T949 T943 prep in,roles
R11 T950 T951 amod mammalian,kidney
R12 T951 T952 compound kidney,development
R13 T952 T949 pobj development,in
R14 T957 T958 det The,gene
R15 T958 T960 nsubj gene,encodes
R16 T959 T958 compound pygopus,gene
R17 T961 T958 prep of,gene
R18 T962 T961 pobj Drosophila,of
R19 T963 T964 det an,component
R20 T964 T960 dobj component,encodes
R21 T965 T964 amod essential,component
R22 T966 T964 prep of,component
R23 T967 T968 det the,complex
R24 T968 T966 pobj complex,of
R25 T969 T970 nmod Armadillo,factor
R26 T970 T968 compound factor,complex
R27 T971 T972 punct (,catenin
R28 T972 T969 parataxis catenin,Armadillo
R29 T973 T972 compound β,catenin
R30 T974 T972 punct -,catenin
R31 T975 T972 punct ),catenin
R32 T976 T970 compound transcription,factor
R33 T977 T968 prep of,complex
R34 T978 T979 amod canonical,signaling
R35 T979 T977 pobj signaling,of
R36 T980 T979 compound Wnt,signaling
R37 T981 T960 punct .,encodes
R38 T983 T984 aux To,understand
R39 T984 T986 advcl understand,made
R40 T985 T984 advmod better,understand
R41 T987 T988 det the,functions
R42 T988 T984 dobj functions,understand
R43 T989 T988 prep of,functions
R44 T990 T991 npadvmod Pygopus,mediated
R45 T991 T993 amod mediated,signaling
R46 T992 T991 punct -,mediated
R47 T993 T989 pobj signaling,of
R48 T994 T993 amod canonical,signaling
R49 T995 T993 compound Wnt,signaling
R50 T996 T988 prep in,functions
R51 T997 T998 compound kidney,development
R52 T998 T996 pobj development,in
R53 T999 T986 punct ", ",made
R54 T1000 T1001 amod targeted,mutations
R55 T1001 T986 nsubjpass mutations,made
R56 T1002 T986 auxpass were,made
R57 T1003 T986 prep in,made
R58 T1004 T1005 det the,orthologs
R59 T1005 T1003 pobj orthologs,in
R60 T1006 T1005 nummod two,orthologs
R61 T1007 T1005 amod mammalian,orthologs
R62 T1008 T1005 punct ", ",orthologs
R63 T1009 T1005 appos Pygo1,orthologs
R64 T1010 T1009 cc and,Pygo1
R65 T1011 T1009 conj Pygo2,Pygo1
R66 T1012 T986 punct .,made
R67 T1016 T1017 det Each,mutation
R68 T1017 T1018 nsubj mutation,resulted
R69 T1019 T1018 aux deleted,resulted
R70 T1020 T1021 punct >,80
R71 T1021 T1022 nummod 80,%
R72 T1022 T1018 dobj %,resulted
R73 T1023 T1022 prep of,%
R74 T1024 T1025 det the,sequence
R75 T1025 T1023 pobj sequence,of
R76 T1026 T1025 compound coding,sequence
R77 T1027 T1022 punct ", ",%
R78 T1028 T1022 prep including,%
R79 T1029 T1030 det the,domain
R80 T1030 T1028 pobj domain,including
R81 T1031 T1030 amod critical,domain
R82 T1032 T1030 compound PHD,domain
R83 T1033 T1018 punct ", ",resulted
R84 T1034 T1018 cc and,resulted
R85 T1035 T1036 advmod almost,certainly
R86 T1036 T1018 advmod certainly,resulted
R87 T1037 T1018 prep in,resulted
R88 T1038 T1039 amod null,function
R89 T1039 T1037 pobj function,in
R90 T1040 T1018 punct .,resulted
R91 T1042 T1043 npadvmod Pygo2,homozygous
R92 T1043 T1044 amod homozygous,mutants
R93 T1044 T1045 nsubj mutants,died
R94 T1046 T1045 punct ", ",died
R95 T1047 T1045 prep with,died
R96 T1048 T1049 amod rare,exception
R97 T1049 T1047 pobj exception,with
R98 T1050 T1045 punct ", ",died
R99 T1051 T1052 advmod shortly,after
R100 T1052 T1045 prep after,died
R101 T1053 T1052 pobj birth,after
R102 T1054 T1045 punct ", ",died
R103 T1055 T1045 prep with,died
R104 T1056 T1057 det a,phenotype
R105 T1057 T1055 pobj phenotype,with
R106 T1058 T1057 prep including,phenotype
R107 T1059 T1060 compound lens,agenesis
R108 T1060 T1058 pobj agenesis,including
R109 T1061 T1060 punct ", ",agenesis
R110 T1062 T1063 compound growth,retardation
R111 T1063 T1060 conj retardation,agenesis
R112 T1064 T1063 punct ", ",retardation
R113 T1065 T1066 amod altered,development
R114 T1066 T1063 conj development,retardation
R115 T1067 T1066 compound kidney,development
R116 T1068 T1066 punct ", ",development
R117 T1069 T1066 cc and,development
R118 T1070 T1071 prep in,exencephaly
R119 T1071 T1066 conj exencephaly,development
R120 T1072 T1073 det some,cases
R121 T1073 T1070 pobj cases,in
R122 T1074 T1071 cc and,exencephaly
R123 T1075 T1076 amod cleft,palate
R124 T1076 T1071 conj palate,exencephaly
R125 T1077 T1045 punct .,died
R126 T1079 T1080 npadvmod Pygo1,homozygous
R127 T1080 T1081 amod homozygous,mutants
R128 T1081 T1082 nsubj mutants,were
R129 T1083 T1082 punct ", ",were
R130 T1084 T1082 advmod however,were
R131 T1085 T1082 punct ", ",were
R132 T1086 T1082 acomp viable,were
R133 T1087 T1086 cc and,viable
R134 T1088 T1086 conj fertile,viable
R135 T1089 T1082 punct ", ",were
R136 T1090 T1082 prep with,were
R137 T1091 T1092 det no,defects
R138 T1092 T1090 pobj defects,with
R139 T1093 T1092 amod detectable,defects
R140 T1094 T1092 amod developmental,defects
R141 T1095 T1082 punct .,were
R142 T1097 T1098 amod Double,Pygo2
R143 T1098 T1101 npadvmod Pygo2,homozygous
R144 T1099 T1098 compound Pygo1,Pygo2
R145 T1100 T1098 punct /,Pygo2
R146 T1101 T1102 amod homozygous,mutants
R147 T1102 T1103 nsubj mutants,showed
R148 T1104 T1105 det no,synergy
R149 T1105 T1103 dobj synergy,showed
R150 T1106 T1105 amod apparent,synergy
R151 T1107 T1105 prep in,synergy
R152 T1108 T1109 compound phenotype,severity
R153 T1109 T1107 pobj severity,in
R154 T1110 T1103 punct .,showed
R155 T1112 T1113 det The,reporter
R156 T1113 T1118 nsubj reporter,showed
R157 T1114 T1115 compound BAT,gal
R158 T1115 T1117 compound gal,transgene
R159 T1116 T1115 punct -,gal
R160 T1117 T1113 compound transgene,reporter
R161 T1119 T1113 prep of,reporter
R162 T1120 T1121 amod canonical,signaling
R163 T1121 T1119 pobj signaling,of
R164 T1122 T1121 compound Wnt,signaling
R165 T1123 T1124 amod reduced,levels
R166 T1124 T1118 dobj levels,showed
R167 T1125 T1124 prep of,levels
R168 T1126 T1125 pobj expression,of
R169 T1127 T1124 prep in,levels
R170 T1128 T1129 nmod Pygo1,mutants
R171 T1129 T1127 pobj mutants,in
R172 T1130 T1128 punct -,Pygo1
R173 T1131 T1128 punct /,Pygo1
R174 T1132 T1128 punct -,Pygo1
R175 T1133 T1128 punct /,Pygo1
R176 T1134 T1128 appos Pygo2,Pygo1
R177 T1135 T1134 punct -,Pygo2
R178 T1136 T1134 punct /,Pygo2
R179 T1137 T1134 punct -,Pygo2
R180 T1138 T1118 punct ", ",showed
R181 T1139 T1118 prep with,showed
R182 T1140 T1141 npadvmod tissue,specific
R183 T1141 T1143 amod specific,variation
R184 T1142 T1141 punct -,specific
R185 T1143 T1139 pobj variation,with
R186 T1144 T1143 prep in,variation
R187 T1145 T1144 pobj degree,in
R188 T1146 T1145 prep of,degree
R189 T1147 T1146 pobj diminution,of
R190 T1148 T1118 punct .,showed
R191 T1150 T1151 det The,genes
R193 T1152 T1151 nmod Pygo1,genes
R194 T1153 T1152 cc and,Pygo1
R195 T1154 T1152 conj Pygo2,Pygo1
R196 T1156 T1151 appos both,genes
R197 T1157 T1158 amod widespread,expression
R198 T1158 T1155 dobj expression,showed
R199 T1159 T1158 prep in,expression
R200 T1160 T1161 det the,kidney
R201 T1161 T1159 pobj kidney,in
R202 T1162 T1161 amod developing,kidney
R203 T1163 T1155 punct ", ",showed
R204 T1164 T1155 prep with,showed
R205 T1165 T1166 amod raised,levels
R206 T1166 T1164 pobj levels,with
R207 T1167 T1166 prep in,levels
R208 T1168 T1169 det the,compartment
R209 T1169 T1167 pobj compartment,in
R210 T1170 T1171 amod stromal,cell
R211 T1171 T1169 compound cell,compartment
R212 T1172 T1155 punct .,showed
R213 T1174 T1175 amod Confocal,analysis
R214 T1175 T1176 nsubj analysis,showed
R215 T1177 T1175 prep of,analysis
R216 T1178 T1179 det the,kidneys
R217 T1179 T1177 pobj kidneys,of
R218 T1180 T1181 amod double,mutant
R219 T1181 T1179 compound mutant,kidneys
R220 T1182 T1176 dobj disturbance,showed
R221 T1183 T1182 prep of,disturbance
R222 T1184 T1185 preconj both,compartments
R223 T1185 T1183 pobj compartments,of
R224 T1186 T1185 det the,compartments
R225 T1187 T1188 amod ureteric,bud
R226 T1188 T1189 npadvmod bud,derived
R228 T1190 T1188 cc and,bud
R229 T1191 T1192 amod metanephric,mesenchyme
R230 T1192 T1188 conj mesenchyme,bud
R231 T1193 T1189 punct -,derived
R232 T1194 T1176 punct .,showed
R233 T1196 T1197 amod Branching,morphogenesis
R234 T1197 T1198 nsubjpass morphogenesis,altered
R235 T1199 T1197 prep of,morphogenesis
R236 T1200 T1201 det the,bud
R237 T1201 T1199 pobj bud,of
R238 T1202 T1201 amod ureteric,bud
R239 T1203 T1198 auxpass was,altered
R240 T1204 T1198 punct ", ",altered
R241 T1205 T1198 prep with,altered
R242 T1206 T1207 amod expanded,tips
R243 T1207 T1205 pobj tips,with
R244 T1208 T1207 cc and,tips
R245 T1209 T1210 amod reduced,density
R246 T1210 T1207 conj density,tips
R247 T1211 T1210 compound tip,density
R248 T1212 T1198 punct ", ",altered
R249 T1213 T1214 advmod probably,contributing
R250 T1214 T1198 advcl contributing,altered
R251 T1215 T1214 prep to,contributing
R252 T1216 T1217 det the,size
R253 T1217 T1215 pobj size,to
R254 T1218 T1217 amod smaller,size
R255 T1219 T1217 prep of,size
R256 T1220 T1221 det the,kidney
R257 T1221 T1219 pobj kidney,of
R258 T1222 T1221 compound mutant,kidney
R259 T1223 T1198 punct .,altered
R260 T1225 T1226 prep In,was
R261 T1227 T1225 pobj addition,In
R262 T1228 T1226 punct ", ",was
R263 T1229 T1226 expl there,was
R264 T1230 T1231 det an,expansion
R265 T1231 T1226 attr expansion,was
R266 T1232 T1231 prep of,expansion
R267 T1233 T1234 det the,zone
R268 T1234 T1232 pobj zone,of
R269 T1235 T1234 prep of,zone
R270 T1236 T1237 amod condensed,mesenchyme
R271 T1237 T1235 pobj mesenchyme,of
R272 T1238 T1234 acl capping,zone
R273 T1239 T1240 det the,bud
R274 T1240 T1238 dobj bud,capping
R275 T1241 T1240 amod ureteric,bud
R276 T1242 T1226 punct .,was
R277 T1244 T1245 compound Nephron,formation
R278 T1245 T1246 nsubj formation,proceeded
R279 T1247 T1246 punct ", ",proceeded
R280 T1248 T1246 advmod however,proceeded
R281 T1249 T1246 punct ", ",proceeded
R282 T1250 T1246 advmod normally,proceeded
R283 T1251 T1246 punct .,proceeded
R284 T1253 T1254 compound Microarray,analysis
R285 T1254 T1255 nsubj analysis,showed
R286 T1256 T1257 amod changed,expression
R287 T1257 T1255 dobj expression,showed
R288 T1258 T1257 prep of,expression
R289 T1259 T1260 amod several,genes
R290 T1260 T1258 pobj genes,of
R291 T1261 T1260 punct ", ",genes
R292 T1262 T1260 prep including,genes
R293 T1263 T1262 pobj Cxcl13,including
R294 T1264 T1263 punct ", ",Cxcl13
R295 T1265 T1263 conj Slc5a2,Cxcl13
R296 T1266 T1265 punct ", ",Slc5a2
R297 T1267 T1265 conj Klk5,Slc5a2
R298 T1268 T1267 punct ", ",Klk5
R299 T1269 T1267 conj Ren2,Klk5
R300 T1270 T1269 cc and,Ren2
R301 T1271 T1269 conj Timeless,Ren2
R302 T1272 T1260 punct ", ",genes
R303 T1273 T1274 dep which,represent
R304 T1274 T1260 relcl represent,genes
R305 T1275 T1276 compound candidate,targets
R306 T1276 T1274 dobj targets,represent
R307 T1277 T1276 compound Wnt,targets
R308 T1278 T1276 prep in,targets
R309 T1279 T1280 compound kidney,development
R310 T1280 T1278 pobj development,in
R311 T1281 T1255 punct .,showed
R312 T1285 T1286 det The,genes
R313 T1286 T1289 nsubjpass genes,required
R314 T1287 T1286 amod mammalian,genes
R315 T1288 T1286 compound Pygopus,genes
R316 T1290 T1289 auxpass are,required
R317 T1291 T1289 prep for,required
R318 T1292 T1293 amod normal,morphogenesis
R319 T1293 T1291 pobj morphogenesis,for
R320 T1294 T1293 compound branching,morphogenesis
R321 T1295 T1293 prep of,morphogenesis
R322 T1296 T1297 det the,bud
R323 T1297 T1295 pobj bud,of
R324 T1298 T1297 amod ureteric,bud
R325 T1299 T1293 prep during,morphogenesis
R326 T1300 T1301 compound kidney,development
R327 T1301 T1299 pobj development,during
R328 T1302 T1289 punct .,required
R329 T1304 T1305 advmod Nevertheless,indicates
R330 T1306 T1305 punct ", ",indicates
R331 T1307 T1308 det the,phenotype
R332 T1308 T1305 nsubj phenotype,indicates
R333 T1309 T1310 advmod relatively,mild
R334 T1310 T1308 amod mild,phenotype
R335 T1311 T1308 acl observed,phenotype
R336 T1312 T1311 prep in,observed
R337 T1313 T1314 det the,kidney
R338 T1314 T1312 pobj kidney,in
R339 T1315 T1314 punct ", ",kidney
R340 T1316 T1317 advmod as,as
R341 T1317 T1314 cc as,kidney
R342 T1318 T1317 advmod well,as
R343 T1319 T1320 amod other,systems
R344 T1320 T1314 conj systems,kidney
R345 T1321 T1320 compound organ,systems
R346 T1322 T1305 punct ", ",indicates
R347 T1323 T1324 det a,divergence
R348 T1324 T1305 dobj divergence,indicates
R349 T1325 T1324 amod striking,divergence
R350 T1326 T1324 amod evolutionary,divergence
R351 T1327 T1324 prep of,divergence
R352 T1328 T1329 compound Pygopus,function
R353 T1329 T1327 pobj function,of
R354 T1330 T1324 prep between,divergence
R355 T1331 T1330 pobj mammals,between
R356 T1332 T1331 cc and,mammals
R357 T1333 T1331 conj Drosophila,mammals
R358 T1334 T1305 punct .,indicates
R359 T1336 T1337 prep In,required
R360 T1338 T1336 pobj mammals,In
R361 T1339 T1337 punct ", ",required
R362 T1340 T1341 det the,genes
R364 T1342 T1343 compound Pygo1,Pygo2
R365 T1343 T1341 compound Pygo2,genes
R366 T1344 T1343 punct /,Pygo2
R367 T1345 T1337 auxpass are,required
R368 T1346 T1337 neg not,required
R369 T1347 T1337 advmod absolutely,required
R370 T1348 T1337 prep for,required
R371 T1349 T1350 amod canonical,signaling
R372 T1350 T1348 pobj signaling,for
R373 T1351 T1350 compound Wnt,signaling
R374 T1352 T1337 prep in,required
R375 T1353 T1354 amod most,systems
R376 T1354 T1352 pobj systems,in
R377 T1355 T1354 amod developing,systems
R378 T1356 T1337 punct ", ",required
R379 T1357 T1337 cc but,required
R380 T1358 T1357 advmod rather,but
R381 T1359 T1337 conj function,required
R382 T1360 T1359 prep as,function
R383 T1361 T1362 amod quantitative,transducers
R384 T1362 T1360 pobj transducers,as
R385 T1363 T1362 punct ", ",transducers
R386 T1364 T1362 cc or,transducers
R387 T1365 T1362 conj modulators,transducers
R388 T1366 T1362 punct ", ",transducers
R389 T1367 T1362 prep of,transducers
R390 T1368 T1369 compound Wnt,signal
R391 T1369 T1370 compound signal,intensity
R392 T1370 T1367 pobj intensity,of
R393 T1371 T1337 punct .,required
R398 T2638 T2639 compound Wnt,signaling
R399 T2639 T2640 nsubj signaling,is
R400 T2641 T2640 prep of,is
R401 T2642 T2643 amod critical,importance
R402 T2643 T2641 pobj importance,of
R403 T2644 T2640 prep in,is
R404 T2645 T2646 amod several,stages
R405 T2646 T2644 pobj stages,in
R406 T2647 T2646 prep of,stages
R407 T2648 T2649 compound kidney,development
R408 T2649 T2647 pobj development,of
R409 T2650 T2640 punct .,is
R410 T2652 T2653 amod Mutual,interactions
R411 T2653 T2655 nsubj interactions,drive
R412 T2654 T2653 amod inductive,interactions
R413 T2656 T2653 prep between,interactions
R414 T2657 T2658 det the,bud
R415 T2658 T2656 pobj bud,between
R416 T2659 T2658 amod ureteric,bud
R417 T2660 T2658 cc and,bud
R418 T2661 T2662 amod metanephric,mesenchyme
R419 T2662 T2658 conj mesenchyme,bud
R420 T2663 T2655 dobj nephrogenesis,drive
R421 T2664 T2665 punct [,1
R422 T2665 T2655 parataxis 1,drive
R423 T2666 T2665 punct ],1
R424 T2667 T2655 punct .,drive
R425 T2669 T2670 det The,bud
R426 T2670 T2672 nsubj bud,synthesizes
R427 T2671 T2670 amod ureteric,bud
R428 T2673 T2672 dobj Wnt9b,synthesizes
R429 T2674 T2673 punct ", ",Wnt9b
R430 T2675 T2676 dep which,is
R431 T2676 T2673 relcl is,Wnt9b
R432 T2677 T2676 acomp essential,is
R433 T2678 T2677 prep for,essential
R434 T2679 T2678 pobj induction,for
R435 T2680 T2679 prep of,induction
R436 T2681 T2682 det the,mesenchyme
R437 T2682 T2680 pobj mesenchyme,of
R438 T2683 T2684 aux to,form
R439 T2684 T2679 acl form,induction
R440 T2685 T2684 dobj nephrons,form
R441 T2686 T2687 punct [,2
R442 T2687 T2672 parataxis 2,synthesizes
R443 T2688 T2687 punct ],2
R444 T2689 T2672 punct .,synthesizes
R445 T2691 T2692 nsubjpass Wnt4,made
R446 T2693 T2692 auxpass is,made
R447 T2694 T2692 agent by,made
R448 T2695 T2696 det the,mesenchyme
R449 T2696 T2694 pobj mesenchyme,by
R450 T2697 T2696 amod induced,mesenchyme
R451 T2698 T2696 amod metanephric,mesenchyme
R452 T2699 T2692 cc and,made
R453 T2700 T2701 auxpass is,required
R454 T2701 T2692 conj required,made
R455 T2702 T2701 advmod also,required
R456 T2703 T2701 prep for,required
R457 T2704 T2703 pobj nephrogenesis,for
R458 T2705 T2706 punct [,3
R459 T2706 T2701 parataxis 3,required
R460 T2707 T2706 punct ],3
R461 T2708 T2692 punct .,made
R462 T2710 T2711 advmod Furthermore,participates
R463 T2712 T2711 punct ", ",participates
R464 T2713 T2711 nsubj Wnt11,participates
R465 T2714 T2713 punct ", ",Wnt11
R466 T2715 T2713 acl secreted,Wnt11
R467 T2716 T2715 agent by,secreted
R468 T2717 T2718 det the,tips
R469 T2718 T2716 pobj tips,by
R470 T2719 T2720 amod ureteric,bud
R471 T2720 T2718 compound bud,tips
R472 T2721 T2711 punct ", ",participates
R473 T2722 T2711 prep in,participates
R474 T2723 T2724 det a,loop
R475 T2724 T2722 pobj loop,in
R476 T2725 T2724 amod positive,loop
R477 T2726 T2724 compound feedback,loop
R478 T2727 T2724 acl promoting,loop
R479 T2728 T2729 amod glial,line
R480 T2729 T2731 npadvmod line,derived
R481 T2730 T2729 compound cell,line
R482 T2731 T2733 amod derived,factor
R483 T2732 T2731 punct -,derived
R484 T2733 T2735 nmod factor,expression
R485 T2734 T2733 amod neurotrophic,factor
R486 T2735 T2727 dobj expression,promoting
R487 T2736 T2733 punct (,factor
R488 T2737 T2733 appos GDNF,factor
R489 T2738 T2735 punct ),expression
R490 T2739 T2735 prep by,expression
R491 T2740 T2741 det the,mesenchyme
R492 T2741 T2739 pobj mesenchyme,by
R493 T2742 T2741 amod metanephric,mesenchyme
R494 T2743 T2744 punct [,4
R495 T2744 T2711 parataxis 4,participates
R496 T2745 T2744 punct ],4
R497 T2746 T2711 punct .,participates
R498 T2748 T2749 nsubj Mutations,result
R499 T2750 T2748 prep in,Mutations
R500 T2751 T2750 pobj Wnt9b,in
R501 T2752 T2751 cc or,Wnt9b
R502 T2753 T2751 conj Wnt4,Wnt9b
R503 T2754 T2749 prep in,result
R504 T2755 T2756 det a,block
R505 T2756 T2754 pobj block,in
R506 T2757 T2756 amod dramatic,block
R507 T2758 T2756 prep in,block
R508 T2759 T2760 compound nephron,formation
R509 T2760 T2758 pobj formation,in
R510 T2761 T2749 punct ", ",result
R511 T2762 T2763 mark while,show
R512 T2763 T2749 advcl show,result
R513 T2764 T2765 compound Wnt11,mutants
R514 T2765 T2763 nsubj mutants,show
R515 T2766 T2767 det a,reduction
R516 T2767 T2763 dobj reduction,show
R517 T2768 T2767 amod significant,reduction
R518 T2769 T2767 prep in,reduction
R519 T2770 T2771 compound nephron,number
R520 T2771 T2769 pobj number,in
R521 T2772 T2749 punct .,result
R522 T2774 T2775 nsubj It,is
R523 T2776 T2775 acomp interesting,is
R524 T2777 T2778 aux to,note
R525 T2778 T2775 xcomp note,is
R526 T2779 T2780 mark that,shown
R527 T2780 T2778 ccomp shown,note
R528 T2781 T2780 nsubjpass Wnt4,shown
R529 T2782 T2781 cc and,Wnt4
R530 T2783 T2781 conj Wnt11,Wnt4
R531 T2784 T2780 aux have,shown
R532 T2785 T2780 auxpass been,shown
R533 T2786 T2787 aux to,signal
R534 T2787 T2780 xcomp signal,shown
R535 T2788 T2787 punct ", ",signal
R536 T2789 T2790 advmod at,least
R537 T2790 T2791 advmod least,in
R538 T2791 T2787 prep in,signal
R539 T2792 T2793 det some,cases
R540 T2793 T2791 pobj cases,in
R541 T2794 T2787 punct ", ",signal
R542 T2795 T2787 prep through,signal
R543 T2796 T2797 amod noncanonical,pathways
R544 T2797 T2795 pobj pathways,through
R545 T2798 T2799 punct [,5
R546 T2799 T2787 parataxis 5,signal
R547 T2800 T2801 punct -,7
R548 T2801 T2799 prep 7,5
R549 T2802 T2799 punct ],5
R550 T2803 T2778 punct ", ",note
R551 T2804 T2805 mark while,is
R552 T2805 T2778 advcl is,note
R553 T2806 T2805 expl there,is
R554 T2807 T2805 attr evidence,is
R555 T2808 T2807 acl indicating,evidence
R556 T2809 T2810 mark that,activates
R557 T2810 T2808 ccomp activates,indicating
R558 T2811 T2810 nsubj Wnt9b,activates
R559 T2812 T2813 amod canonical,signaling
R560 T2813 T2810 dobj signaling,activates
R561 T2814 T2813 compound Wnt,signaling
R562 T2815 T2810 prep in,activates
R563 T2816 T2817 det the,kidney
R564 T2817 T2815 pobj kidney,in
R565 T2818 T2819 punct [,2
R566 T2819 T2810 parataxis 2,activates
R567 T2820 T2819 punct ],2
R568 T2821 T2775 punct .,is
R569 T2823 T2824 amod Genetic,studies
R570 T2824 T2825 nsubj studies,identified
R571 T2826 T2824 prep in,studies
R572 T2827 T2826 pobj Drosophila,in
R573 T2828 T2825 aux have,identified
R574 T2829 T2830 det the,gene
R575 T2830 T2825 dobj gene,identified
R576 T2831 T2830 nmod Pygopus,gene
R577 T2832 T2831 punct (,Pygopus
R578 T2833 T2831 appos Pygo,Pygopus
R579 T2834 T2830 punct ),gene
R580 T2835 T2825 prep as,identified
R581 T2836 T2837 det a,component
R582 T2837 T2835 pobj component,as
R583 T2838 T2837 amod critical,component
R584 T2839 T2837 prep of,component
R585 T2840 T2841 amod canonical,signaling
R586 T2841 T2839 pobj signaling,of
R587 T2842 T2841 compound Wnt,signaling
R588 T2843 T2844 punct [,8
R589 T2844 T2825 parataxis 8,identified
R590 T2845 T2846 punct -,11
R591 T2846 T2844 prep 11,8
R592 T2847 T2844 punct ],8
R593 T2848 T2825 punct .,identified
R594 T2850 T2851 nsubj Pygo,interact
R595 T2852 T2850 cc and,Pygo
R596 T2853 T2850 conj Lgs,Pygo
R597 T2854 T2851 prep with,interact
R598 T2855 T2856 compound β,catenin
R599 T2856 T2854 pobj catenin,with
R600 T2857 T2856 punct -,catenin
R601 T2858 T2851 prep during,interact
R602 T2859 T2860 det the,formation
R603 T2860 T2858 pobj formation,during
R604 T2861 T2860 prep of,formation
R605 T2862 T2863 det the,complex
R606 T2863 T2861 pobj complex,of
R607 T2864 T2863 amod canonical,complex
R608 T2865 T2863 amod transcriptional,complex
R609 T2866 T2851 cc and,interact
R610 T2867 T2868 auxpass are,required
R611 T2868 T2851 conj required,interact
R612 T2869 T2868 prep for,required
R613 T2870 T2869 pobj accumulation,for
R614 T2871 T2870 prep of,accumulation
R615 T2872 T2873 compound β,catenin
R616 T2873 T2871 pobj catenin,of
R617 T2874 T2873 punct -,catenin
R618 T2875 T2870 prep in,accumulation
R619 T2876 T2877 det the,nucleus
R620 T2877 T2875 pobj nucleus,in
R621 T2878 T2879 punct [,12
R622 T2879 T2868 parataxis 12,required
R623 T2880 T2879 punct ],12
R624 T2881 T2851 punct .,interact
R625 T2883 T2884 nsubj Lgs,binds
R626 T2885 T2886 det the,repeats
R627 T2886 T2884 dobj repeats,binds
R628 T2887 T2886 amod central,repeats
R629 T2888 T2886 compound armadillo,repeats
R630 T2889 T2886 prep of,repeats
R631 T2890 T2891 compound β,catenin
R632 T2891 T2889 pobj catenin,of
R633 T2892 T2891 punct -,catenin
R634 T2893 T2884 punct ", ",binds
R635 T2894 T2895 mark while,interacts
R636 T2895 T2884 advcl interacts,binds
R637 T2896 T2895 nsubj Pygo,interacts
R638 T2897 T2895 prep with,interacts
R639 T2898 T2897 pobj Lgs,with
R640 T2899 T2895 punct ", ",interacts
R641 T2900 T2895 advcl mediating,interacts
R642 T2901 T2900 dobj activation,mediating
R643 T2902 T2901 prep of,activation
R644 T2903 T2904 compound Wnt,targets
R645 T2904 T2902 pobj targets,of
R646 T2905 T2906 punct [,13
R647 T2906 T2895 parataxis 13,interacts
R648 T2907 T2906 nummod 9,13
R649 T2908 T2906 punct ",",13
R650 T2909 T2906 punct ],13
R651 T2910 T2884 punct .,binds
R652 T2912 T2913 det The,domain
R653 T2913 T2917 nsubjpass domain,required
R654 T2914 T2915 npadvmod N,terminal
R655 T2915 T2913 amod terminal,domain
R656 T2916 T2915 punct -,terminal
R657 T2918 T2913 prep of,domain
R658 T2919 T2918 pobj Pygo,of
R659 T2920 T2917 auxpass is,required
R660 T2921 T2917 prep for,required
R661 T2922 T2923 nmod Wnt,activation
R662 T2923 T2921 pobj activation,for
R663 T2924 T2923 amod transcriptional,activation
R664 T2925 T2917 punct ", ",required
R665 T2926 T2927 mark while,required
R666 T2927 T2917 advcl required,required
R667 T2928 T2929 det the,motif
R668 T2929 T2927 nsubjpass motif,required
R669 T2930 T2929 compound PHD,motif
R670 T2931 T2927 auxpass is,required
R671 T2932 T2927 prep for,required
R672 T2933 T2934 det the,association
R673 T2934 T2932 pobj association,for
R674 T2935 T2934 prep of,association
R675 T2936 T2935 pobj Pygo,of
R676 T2937 T2934 prep with,association
R677 T2938 T2937 pobj Lgs,with
R678 T2939 T2940 punct [,13
R679 T2940 T2927 parataxis 13,required
R680 T2941 T2940 nummod 9,13
R681 T2942 T2940 punct ",",13
R682 T2943 T2940 punct ],13
R683 T2944 T2917 punct .,required
R684 T2946 T2947 advmod Additionally,identified
R685 T2948 T2947 punct ", ",identified
R686 T2949 T2950 det a,signal
R687 T2950 T2947 nsubjpass signal,identified
R688 T2951 T2950 amod putative,signal
R689 T2952 T2950 amod nuclear,signal
R690 T2953 T2950 compound localization,signal
R691 T2954 T2950 punct (,signal
R692 T2955 T2950 appos NLS,signal
R693 T2956 T2947 punct ),identified
R694 T2957 T2947 auxpass was,identified
R695 T2958 T2947 prep within,identified
R696 T2959 T2960 det the,domain
R697 T2960 T2958 pobj domain,within
R698 T2961 T2962 npadvmod N,terminal
R699 T2962 T2960 amod terminal,domain
R700 T2963 T2962 punct -,terminal
R701 T2964 T2960 prep of,domain
R702 T2965 T2964 pobj Pygo,of
R703 T2966 T2947 punct ", ",identified
R704 T2967 T2947 advcl suggesting,identified
R705 T2968 T2969 det a,role
R706 T2969 T2967 dobj role,suggesting
R707 T2970 T2969 amod possible,role
R708 T2971 T2969 prep of,role
R709 T2972 T2973 amod nuclear,importation
R710 T2973 T2971 pobj importation,of
R711 T2974 T2973 prep of,importation
R712 T2975 T2976 compound β,catenin
R713 T2976 T2974 pobj catenin,of
R714 T2977 T2976 punct -,catenin
R715 T2978 T2979 punct [,11
R716 T2979 T2947 parataxis 11,identified
R717 T2980 T2979 nummod 8,11
R718 T2981 T2979 punct ",",11
R719 T2982 T2979 punct ],11
R720 T2983 T2947 punct .,identified
R721 T2985 T2986 nsubj Analyses,indicate
R722 T2987 T2985 prep of,Analyses
R723 T2988 T2989 amod multiple,aspects
R724 T2989 T2987 pobj aspects,of
R725 T2990 T2989 prep of,aspects
R726 T2991 T2992 det the,phenotype
R727 T2992 T2990 pobj phenotype,of
R728 T2993 T2994 compound pygopus,mutant
R729 T2994 T2992 compound mutant,phenotype
R730 T2995 T2996 mark that,dedicated
R731 T2996 T2986 ccomp dedicated,indicate
R732 T2997 T2998 det this,gene
R733 T2998 T2996 nsubjpass gene,dedicated
R734 T2999 T2996 auxpass is,dedicated
R735 T3000 T2996 prep to,dedicated
R736 T3001 T2996 punct ", ",dedicated
R737 T3002 T2996 cc and,dedicated
R738 T3003 T2996 conj required,dedicated
R739 T3004 T3003 prep for,required
R740 T3005 T3003 punct ", ",required
R741 T3006 T3007 amod canonical,signaling
R742 T3007 T3003 conj signaling,required
R743 T3008 T3007 compound Wnt,signaling
R744 T3009 T2996 prep during,dedicated
R745 T3010 T3011 compound Drosophila,development
R746 T3011 T3009 pobj development,during
R747 T3012 T3013 punct [,9
R748 T3013 T2986 parataxis 9,indicate
R749 T3014 T3013 punct ],9
R750 T3015 T2986 punct .,indicate
R751 T3017 T3018 det The,genome
R752 T3018 T3020 nsubj genome,carries
R753 T3019 T3018 amod mammalian,genome
R754 T3021 T3022 nummod two,orthologs
R755 T3022 T3020 dobj orthologs,carries
R756 T3023 T3021 punct ", ",two
R757 T3024 T3021 cc and,two
R758 T3025 T3026 advmod only,two
R759 T3026 T3021 conj two,two
R760 T3027 T3022 punct ", ",orthologs
R761 T3028 T3022 prep of,orthologs
R762 T3029 T3030 compound Drosophila,Pygo
R763 T3030 T3028 pobj Pygo,of
R764 T3031 T3022 punct ", ",orthologs
R765 T3032 T3022 appos Pygo1,orthologs
R766 T3033 T3032 cc and,Pygo1
R767 T3140 T3139 compound branching,morphogenesis
R768 T3141 T3139 prep of,morphogenesis
R769 T3142 T3143 det the,bud
R770 T3143 T3141 pobj bud,of
R771 T3144 T3143 amod ureteric,bud
R772 T3145 T3139 punct ", ",morphogenesis
R773 T3146 T3139 cc and,morphogenesis
R774 T3147 T3139 conj expansion,morphogenesis
R775 T3148 T3147 prep of,expansion
R776 T3149 T3150 det the,zone
R777 T3150 T3148 pobj zone,of
R778 T3151 T3150 prep of,zone
R779 T3152 T3153 amod condensed,mesenchyme
R780 T3153 T3151 pobj mesenchyme,of
R781 T3034 T3032 conj Pygo2,Pygo1
R782 T3154 T3150 acl surrounding,zone
R783 T3035 T3036 punct [,14
R784 T3155 T3156 det the,bud
R785 T3036 T3020 parataxis 14,carries
R786 T3037 T3036 nummod 8,14
R787 T3156 T3154 dobj bud,surrounding
R788 T3038 T3036 punct ",",14
R789 T3039 T3036 nummod 9,14
R790 T3040 T3036 punct ",",14
R791 T3157 T3156 amod ureteric,bud
R792 T3041 T3036 punct ],14
R793 T3042 T3020 punct .,carries
R794 T3158 T3139 punct ", ",morphogenesis
R795 T3044 T3045 prep In,generated
R796 T3159 T3139 cc yet,morphogenesis
R797 T3046 T3047 det this,report
R798 T3047 T3044 pobj report,In
R799 T3160 T3161 advmod relatively,normal
R800 T3048 T3045 punct ", ",generated
R801 T3049 T3045 nsubj we,generated
R802 T3050 T3051 amod targeted,mutations
R803 T3051 T3045 dobj mutations,generated
R804 T3161 T3162 amod normal,formation
R805 T3052 T3051 prep of,mutations
R806 T3053 T3052 pobj Pygo1,of
R807 T3054 T3053 cc and,Pygo1
R808 T3162 T3139 conj formation,morphogenesis
R809 T3055 T3053 conj Pygo2,Pygo1
R810 T3056 T3057 aux to,determine
R811 T3163 T3162 compound nephron,formation
R812 T3057 T3045 advcl determine,generated
R813 T3058 T3059 poss their,functions
R814 T3059 T3057 dobj functions,determine
R815 T3060 T3057 punct ", ",determine
R816 T3061 T3057 prep with,determine
R817 T3062 T3063 det a,interest
R818 T3164 T3137 punct ", ",showed
R819 T3063 T3061 pobj interest,with
R820 T3064 T3063 amod particular,interest
R821 T3065 T3063 prep in,interest
R822 T3165 T3166 mark as,measured
R823 T3066 T3067 det the,contributions
R824 T3067 T3065 pobj contributions,in
R825 T3166 T3137 advcl measured,showed
R826 T3068 T3067 prep of,contributions
R827 T3069 T3070 det these,genes
R828 T3167 T3166 prep by,measured
R829 T3070 T3068 pobj genes,of
R830 T3071 T3067 prep to,contributions
R831 T3072 T3073 amod canonical,signaling
R832 T3168 T3167 pobj histology,by
R833 T3073 T3071 pobj signaling,to
R834 T3074 T3073 compound Wnt,signaling
R835 T3075 T3073 prep during,signaling
R836 T3169 T3168 punct ", ",histology
R837 T3076 T3077 compound kidney,development
R838 T3077 T3075 pobj development,during
R839 T3078 T3045 punct .,generated
R840 T3170 T3171 amod confocal,analysis
R841 T3080 T3081 det The,embryos
R842 T3081 T3087 nsubj embryos,showed
R843 T3171 T3168 conj analysis,histology
R844 T3082 T3081 amod resulting,embryos
R845 T3083 T3084 amod double,homozygous
R846 T3084 T3081 amod homozygous,embryos
R847 T3172 T3171 punct ", ",analysis
R848 T3085 T3084 punct -,homozygous
R849 T3086 T3081 compound mutant,embryos
R850 T3173 T3174 advmod in,situ
R851 T3088 T3089 det a,reduction
R852 T3089 T3087 dobj reduction,showed
R853 T3174 T3175 amod situ,hybridization
R854 T3090 T3091 npadvmod context,dependent
R855 T3091 T3089 amod dependent,reduction
R856 T3092 T3091 punct -,dependent
R857 T3093 T3089 prep in,reduction
R858 T3175 T3171 conj hybridization,analysis
R859 T3094 T3095 amod canonical,signaling
R860 T3095 T3093 pobj signaling,in
R861 T3176 T3175 cc and,hybridization
R862 T3096 T3095 compound Wnt,signaling
R863 T3097 T3098 mark as,measured
R864 T3098 T3087 advcl measured,showed
R865 T3177 T3178 compound microarray,analysis
R866 T3099 T3098 agent by,measured
R867 T3100 T3101 compound Wnt,reporter
R868 T3178 T3175 conj analysis,hybridization
R869 T3101 T3102 compound reporter,transgene
R870 T3102 T3103 compound transgene,expression
R871 T3103 T3099 pobj expression,by
R872 T3179 T3131 punct .,focused
R873 T3104 T3087 punct .,showed
R874 T3181 T3182 det The,conclusion
R875 T3106 T3107 nsubj Development,remained
R876 T3108 T3107 punct ", ",remained
R877 T3182 T3184 nsubj conclusion,is
R878 T3109 T3107 advmod however,remained
R879 T3110 T3107 punct ", ",remained
R880 T3111 T3112 advmod surprisingly,normal
R881 T3183 T3182 amod obvious,conclusion
R882 T3112 T3107 acomp normal,remained
R883 T3113 T3107 punct ", ",remained
R884 T3114 T3107 prep with,remained
R885 T3185 T3186 mark that,is
R886 T3115 T3114 pobj survival,with
R887 T3116 T3115 prep to,survival
R888 T3117 T3116 pobj birth,to
R889 T3118 T3115 cc and,survival
R890 T3186 T3184 ccomp is,is
R891 T3119 T3120 amod few,defects
R892 T3120 T3115 conj defects,survival
R893 T3121 T3120 amod apparent,defects
R894 T3122 T3120 prep in,defects
R895 T3123 T3124 amod most,systems
R896 T3187 T3186 prep in,is
R897 T3124 T3122 pobj systems,in
R898 T3125 T3124 compound organ,systems
R899 T3126 T3107 punct .,remained
R900 T3128 T3129 poss Our,analysis
R901 T3188 T3187 pobj mammals,in
R902 T3129 T3131 nsubj analysis,focused
R903 T3130 T3129 amod phenotypic,analysis
R905 T3132 T3131 prep on,focused
R906 T3133 T3134 det the,kidney
R907 T3190 T3188 prep unlike,mammals
R908 T3134 T3132 pobj kidney,on
R909 T3135 T3134 punct ", ",kidney
R910 T3136 T3137 dep which,showed
R911 T3137 T3134 relcl showed,kidney
R912 T3191 T3190 pobj Drosophila,unlike
R913 T3138 T3139 amod altered,morphogenesis
R914 T3139 T3137 dobj morphogenesis,showed
R915 T3192 T3186 punct ", ",is
R916 T3193 T3194 npadvmod Pygopus,mediated
R917 T3194 T3196 amod mediated,signaling
R918 T3195 T3194 punct -,mediated
R919 T3196 T3186 nsubj signaling,is
R920 T3197 T3196 amod canonical,signaling
R921 T3198 T3196 compound Wnt,signaling
R922 T3199 T3186 neg not,is
R923 T3200 T3201 advmod absolutely,necessary
R924 T3201 T3186 acomp necessary,is
R925 T3202 T3186 prep in,is
R926 T3203 T3204 amod most,systems
R927 T3204 T3202 pobj systems,in
R928 T3205 T3204 amod developing,systems
R929 T3206 T3204 compound organ,systems
R930 T3207 T3184 punct .,is
R931 T3498 T3499 npadvmod Pygo1,targeted
R932 T3499 T3502 amod targeted,mutations
R933 T3500 T3498 cc and,Pygo1
R934 T3501 T3498 conj Pygo2,Pygo1
R935 T3504 T3505 nsubj We,targeted
R936 T3506 T3507 preconj both,genes
R937 T3507 T3505 dobj genes,targeted
R938 T3508 T3507 det the,genes
R939 T3509 T3507 nmod Pygo1,genes
R940 T3510 T3509 cc and,Pygo1
R941 T3511 T3509 conj Pygo2,Pygo1
R942 T3512 T3505 prep by,targeted
R943 T3513 T3512 pcomp inserting,by
R944 T3514 T3515 compound LoxP,sequences
R945 T3515 T3513 dobj sequences,inserting
R946 T3516 T3517 aux to,flank
R947 T3517 T3513 advcl flank,inserting
R948 T3518 T3519 amod critical,regions
R949 T3519 T3517 dobj regions,flank
R950 T3520 T3519 amod coding,regions
R951 T3521 T3519 prep including,regions
R952 T3522 T3523 det the,domains
R953 T3523 T3521 pobj domains,including
R954 T3524 T3523 compound PHD,domains
R955 T3525 T3505 punct .,targeted
R956 T3527 T3528 det The,mice
R957 T3528 T3531 nsubjpass mice,mated
R958 T3529 T3528 amod resulting,mice
R959 T3530 T3528 amod targeted,mice
R960 T3532 T3531 auxpass were,mated
R961 T3533 T3531 prep with,mated
R962 T3534 T3535 amod transgenic,mice
R963 T3535 T3533 pobj mice,with
R964 T3536 T3537 compound CMV,Cre
R965 T3537 T3535 compound Cre,mice
R966 T3538 T3537 punct -,Cre
R967 T3539 T3540 punct [,15
R968 T3540 T3535 parataxis 15,mice
R969 T3541 T3540 punct ],15
R970 T3542 T3543 aux to,drive
R971 T3543 T3531 advcl drive,mated
R972 T3544 T3545 compound germline,LoxP
R973 T3545 T3546 compound LoxP,recombination
R974 T3546 T3543 dobj recombination,drive
R975 T3547 T3531 punct ", ",mated
R976 T3548 T3531 advcl resulting,mated
R977 T3549 T3548 prep in,resulting
R978 T3550 T3551 det the,alleles
R979 T3551 T3549 pobj alleles,in
R980 T3552 T3551 amod null,alleles
R981 T3553 T3551 compound mutant,alleles
R982 T3554 T3555 dep that,used
R983 T3555 T3551 relcl used,alleles
R984 T3556 T3555 auxpass were,used
R985 T3557 T3555 prep for,used
R986 T3558 T3559 det this,study
R987 T3559 T3557 pobj study,for
R988 T3560 T3531 punct .,mated
R989 T3562 T3563 nsubj PCR,confirmed
R990 T3564 T3565 det the,deletion
R991 T3565 T3563 dobj deletion,confirmed
R992 T3566 T3565 prep of,deletion
R993 T3567 T3568 det the,bulk
R994 T3568 T3566 pobj bulk,of
R995 T3569 T3568 prep of,bulk
R996 T3570 T3571 det the,sequences
R997 T3571 T3569 pobj sequences,of
R998 T3572 T3571 amod coding,sequences
R999 T3573 T3571 prep for,sequences
R1000 T3574 T3575 det both,genes
R1001 T3575 T3573 pobj genes,for
R1002 T3576 T3571 punct ", ",sequences
R1003 T3577 T3571 prep including,sequences
R1004 T3578 T3579 nummod 89,%
R1005 T3579 T3577 pobj %,including
R1006 T3580 T3579 prep of,%
R1007 T3581 T3582 compound coding,sequence
R1008 T3582 T3580 pobj sequence,of
R1009 T3583 T3582 prep for,sequence
R1010 T3584 T3583 pobj Pygo1,for
R1011 T3585 T3579 cc and,%
R1012 T3586 T3587 nummod 87,%
R1013 T3587 T3579 conj %,%
R1014 T3588 T3587 prep of,%
R1015 T3589 T3590 compound coding,sequence
R1016 T3590 T3588 pobj sequence,of
R1017 T3591 T3590 prep for,sequence
R1018 T3592 T3591 pobj Pygo2,for
R1019 T3593 T3563 punct .,confirmed
R1020 T3595 T3596 amod Previous,studies
R1021 T3596 T3597 nsubj studies,shown
R1022 T3598 T3596 prep in,studies
R1023 T3599 T3598 pobj Drosophila,in
R1024 T3600 T3597 aux have,shown
R1025 T3601 T3602 mark that,eliminate
R1026 T3602 T3597 ccomp eliminate,shown
R1027 T3603 T3604 advmod even,mutation
R1028 T3604 T3602 nsubj mutation,eliminate
R1029 T3605 T3604 det a,mutation
R1030 T3606 T3604 amod single,mutation
R1031 T3607 T3604 compound missense,mutation
R1032 T3608 T3604 prep in,mutation
R1033 T3609 T3610 det the,domain
R1034 T3610 T3608 pobj domain,in
R1035 T3611 T3610 compound PHD,domain
R1036 T3612 T3602 aux can,eliminate
R1037 T3613 T3614 compound Pygo,function
R1038 T3614 T3602 dobj function,eliminate
R1039 T3615 T3602 prep in,eliminate
R1040 T3616 T3617 compound Wnt,signaling
R1041 T3617 T3615 pobj signaling,in
R1042 T3618 T3619 punct [,8
R1043 T3619 T3597 parataxis 8,shown
R1044 T3620 T3619 punct ],8
R1045 T3621 T3597 punct .,shown
R1046 T4091 T4092 nmod Pygo1,mutant
R1047 T4092 T4095 compound mutant,phenotypes
R1048 T4093 T4091 cc and,Pygo1
R1049 T4094 T4091 conj Pygo2,Pygo1
R1050 T4097 T4098 npadvmod Pygo1,null
R1051 T4098 T4100 amod null,mice
R1052 T4099 T4098 amod homozygous,null
R1053 T4100 T4101 nsubj mice,were
R1054 T4102 T4101 acomp viable,were
R1055 T4103 T4102 cc and,viable
R1056 T4104 T4102 conj fertile,viable
R1057 T4105 T4106 mark with,detectable
R1058 T4106 T4101 advcl detectable,were
R1059 T4107 T4108 det no,defects
R1060 T4108 T4106 nsubj defects,detectable
R1061 T4109 T4108 amod developmental,defects
R1062 T4110 T4101 punct .,were
R1063 T4112 T4113 nsubj This,was
R1064 T4114 T4113 acomp surprising,was
R1065 T4115 T4113 prep given,was
R1066 T4116 T4117 det the,importance
R1067 T4117 T4115 pobj importance,given
R1068 T4118 T4117 prep of,importance
R1069 T4119 T4120 det the,gene
R1070 T4120 T4118 pobj gene,of
R1071 T4121 T4120 compound pygopus,gene
R1072 T4122 T4117 prep in,importance
R1073 T4123 T4124 compound Wnt,signaling
R1074 T4124 T4122 pobj signaling,in
R1075 T4125 T4117 prep in,importance
R1076 T4126 T4125 pobj Drosophila,in
R1077 T4127 T4117 punct ", ",importance
R1078 T4128 T4117 cc and,importance
R1079 T4129 T4130 det the,expression
R1080 T4130 T4117 conj expression,importance
R1081 T4131 T4130 amod reported,expression
R1082 T4132 T4130 prep during,expression
R1083 T4133 T4132 pobj development,during
R1084 T4134 T4133 prep of,development
R1085 T4135 T4136 det the,gene
R1086 T4136 T4134 pobj gene,of
R1087 T4137 T4136 compound mouse,gene
R1088 T4138 T4136 compound Pygo1,gene
R1089 T4139 T4130 prep in,expression
R1090 T4140 T4139 punct ", ",in
R1091 T4141 T4139 prep for,in
R1092 T4142 T4141 pobj example,for
R1093 T4143 T4139 punct ", ",in
R1094 T4144 T4145 det the,brain
R1095 T4145 T4139 pobj brain,in
R1096 T4146 T4145 punct ", ",brain
R1097 T4147 T4145 conj limbs,brain
R1098 T4148 T4147 punct ", ",limbs
R1099 T4149 T4147 conj kidney,limbs
R1100 T4150 T4149 cc and,kidney
R1101 T4151 T4152 amod branchial,arches
R1102 T4152 T4149 conj arches,kidney
R1103 T4153 T4154 punct [,16
R1104 T4154 T4145 parataxis 16,brain
R1105 T4155 T4154 nummod 14,16
R1106 T4156 T4154 punct ",",16
R1107 T4157 T4154 punct ],16
R1108 T4158 T4159 punct (,Yu
R1109 T4159 T4113 meta Yu,was
R1110 T4160 T4159 nmod J,Yu
R1111 T4161 T4159 punct ", ",Yu
R1112 T4162 T4159 nmod Valerius,Yu
R1113 T4163 T4159 nmod MT,Yu
R1114 T4164 T4159 punct ", ",Yu
R1115 T4165 T4159 nmod McMahon,Yu
R1116 T4166 T4159 nmod AP,Yu
R1117 T4167 T4159 punct ", ",Yu
R1118 T4168 T4159 nmod contribution,Yu
R1119 T4169 T4159 nmod to,Yu
R1120 T4170 T4159 nmod GUDMAP,Yu
R1121 T4171 T4159 punct ", ",Yu
R1122 T4172 T4159 punct ),Yu
R1123 T4173 T4113 punct .,was
R1124 T4175 T4176 det The,mice
R1125 T4176 T4180 nsubj mice,survived
R1126 T4177 T4178 npadvmod Pygo2,null
R1127 T4178 T4176 amod null,mice
R1128 T4179 T4178 amod homozygous,null
R1129 T4181 T4180 prep to,survived
R1130 T4182 T4181 pobj birth,to
R1131 T4183 T4180 punct ", ",survived
R1132 T4184 T4180 cc but,survived
R1133 T4185 T4186 prep with,died
R1134 T4186 T4180 conj died,survived
R1135 T4187 T4188 amod rare,exceptions
R1136 T4188 T4185 pobj exceptions,with
R1137 T4189 T4186 punct ", ",died
R1138 T4190 T4191 advmod shortly,afterwards
R1139 T4191 T4186 advmod afterwards,died
R1140 T4192 T4180 punct .,survived
R1141 T4194 T4195 det The,gut
R1142 T4195 T4196 nsubj gut,developed
R1143 T4197 T4195 punct ", ",gut
R1144 T4198 T4195 conj heart,gut
R1145 T4199 T4198 cc and,heart
R1146 T4200 T4198 conj limbs,heart
R1147 T4201 T4196 prep without,developed
R1148 T4202 T4203 amod detectable,abnormality
R1149 T4203 T4201 pobj abnormality,without
R1150 T4204 T4205 punct (,shown
R1151 T4205 T4203 parataxis shown,abnormality
R1152 T4206 T4205 nsubj data,shown
R1153 T4207 T4205 neg not,shown
R1154 T4208 T4205 punct ),shown
R1155 T4209 T4196 prep despite,developed
R1156 T4210 T4211 amod known,requirements
R1157 T4211 T4209 pobj requirements,despite
R1158 T4212 T4211 prep for,requirements
R1159 T4213 T4214 compound Wnt,signaling
R1160 T4214 T4212 pobj signaling,for
R1161 T4215 T4196 punct .,developed
R1162 T4217 T4218 det The,mutants
R1163 T4218 T4220 nsubj mutants,show
R1164 T4219 T4218 compound Pygo2,mutants
R1165 T4221 T4220 aux did,show
R1166 T4222 T4220 punct ", ",show
R1167 T4223 T4220 advmod however,show
R1168 T4224 T4220 punct ", ",show
R1169 T4225 T4226 compound growth,retardation
R1170 T4226 T4220 dobj retardation,show
R1171 T4227 T4226 punct ", ",retardation
R1172 T4228 T4229 compound lens,agenesis
R1173 T4229 T4226 conj agenesis,retardation
R1174 T4230 T4229 cc and,agenesis
R1175 T4231 T4232 det a,phenotype
R1176 T4232 T4229 conj phenotype,agenesis
R1177 T4233 T4232 compound kidney,phenotype
R1178 T4234 T4232 prep with,phenotype
R1179 T4235 T4236 amod high,penetrance
R1180 T4236 T4234 pobj penetrance,with
R1181 T4237 T4232 punct ", ",phenotype
R1182 T4238 T4232 conj exencephaly,phenotype
R1183 T4239 T4238 punct ", ",exencephaly
R1184 T4240 T4238 cc and,exencephaly
R1185 T4241 T4242 amod cleft,palate
R1186 T4242 T4238 conj palate,exencephaly
R1187 T4243 T4242 prep with,palate
R1188 T4244 T4245 amod incomplete,penetrance
R1189 T4245 T4243 pobj penetrance,with
R1190 T4246 T4220 punct .,show
R1191 T4248 T4249 amod Double,homozygous
R1192 T4249 T4251 amod homozygous,mice
R1193 T4250 T4249 punct -,homozygous
R1194 T4251 T4256 nsubj mice,had
R1195 T4252 T4251 nmod mutant,mice
R1196 T4253 T4251 nmod Pygo1,mice
R1197 T4254 T4253 cc and,Pygo1
R1198 T4255 T4253 conj Pygo2,Pygo1
R1199 T4257 T4258 det a,phenotype
R1200 T4258 T4256 dobj phenotype,had
R1201 T4259 T4258 amod similar,phenotype
R1202 T4260 T4259 prep to,similar
R1203 T4261 T4260 pobj that,to
R1204 T4262 T4261 prep of,that
R1205 T4263 T4264 amod single,nulls
R1206 T4264 T4262 pobj nulls,of
R1207 T4265 T4264 compound Pygo2,nulls
R1208 T4266 T4267 punct (,Table
R1209 T4267 T4256 parataxis Table,had
R1210 T4268 T4267 dep Figure,Table
R1211 T4269 T4268 nummod 1,Figure
R1212 T4270 T4267 punct ", ",Table
R1213 T4271 T4267 nummod 1,Table
R1214 T4272 T4267 punct ),Table
R1215 T4273 T4256 punct .,had
R1216 T4275 T4276 expl There,was
R1217 T4277 T4278 det no,synergism
R1218 T4278 T4276 attr synergism,was
R1219 T4279 T4278 amod significant,synergism
R1220 T4280 T4278 prep of,synergism
R1221 T4281 T4282 amod developmental,abnormalities
R1222 T4282 T4280 pobj abnormalities,of
R1223 T4283 T4278 prep in,synergism
R1224 T4284 T4285 det the,mutants
R1225 T4285 T4283 pobj mutants,in
R1226 T4286 T4285 amod double,mutants
R1227 T4287 T4276 punct .,was
R1228 T4289 T4290 advmod Together,suggest
R1229 T4291 T4292 det these,results
R1230 T4292 T4290 nsubj results,suggest
R1231 T4293 T4294 mark that,required
R1232 T4294 T4290 ccomp required,suggest
R1233 T4295 T4294 nsubjpass Pygo2,required
R1234 T4296 T4294 auxpass is,required
R1235 T4297 T4294 prep for,required
R1236 T4298 T4299 det the,development
R1237 T4299 T4297 pobj development,for
R1238 T4300 T4299 amod proper,development
R1239 T4301 T4299 prep of,development
R1240 T4302 T4303 det a,number
R1241 T4303 T4301 pobj number,of
R1242 T4304 T4303 amod limited,number
R1243 T4305 T4303 prep of,number
R1244 T4306 T4305 pobj structures,of
R1245 T4307 T4294 punct ", ",required
R1246 T4308 T4309 mark whereas,is
R1247 T4309 T4294 advcl is,required
R1248 T4310 T4309 nsubj Pygo1,is
R1249 T4311 T4309 neg not,is
R1250 T4312 T4309 acomp necessary,is
R1251 T4313 T4312 prep for,necessary
R1252 T4314 T4315 amod normal,development
R1253 T4315 T4313 pobj development,for
R1254 T4316 T4290 punct .,suggest
R1257 T4630 T4629 prep of,Expression
R1258 T4631 T4630 pobj Pygo1,of
R1259 T4632 T4631 cc and,Pygo1
R1260 T4633 T4631 conj Pygo2,Pygo1
R1261 T4634 T4629 prep in,Expression
R1262 T4635 T4636 det the,kidney
R1263 T4636 T4634 pobj kidney,in
R1264 T4637 T4636 amod developing,kidney
R1265 T4639 T4640 advmod In,situ
R1266 T4640 T4641 amod situ,hybridization
R1267 T4641 T4642 nsubjpass hybridization,used
R1268 T4643 T4642 aux has,used
R1269 T4644 T4642 auxpass been,used
R1270 T4645 T4642 advmod previously,used
R1271 T4646 T4647 aux to,characterize
R1272 T4647 T4642 advcl characterize,used
R1273 T4648 T4647 dobj expression,characterize
R1274 T4649 T4648 prep of,expression
R1275 T4650 T4649 pobj Pygo1,of
R1276 T4651 T4652 punct [,16
R1277 T4652 T4642 parataxis 16,used
R1278 T4653 T4652 nummod 14,16
R1279 T4654 T4652 punct ",",16
R1280 T4655 T4652 punct ],16
R1281 T4656 T4657 punct (,Yu
R1282 T4657 T4642 meta Yu,used
R1283 T4658 T4657 nmod J,Yu
R1284 T4659 T4657 punct ", ",Yu
R1285 T4660 T4657 nmod Valerius,Yu
R1286 T4661 T4657 nmod MT,Yu
R1287 T4662 T4657 punct ", ",Yu
R1288 T4663 T4657 nmod McMahon,Yu
R1289 T4664 T4657 nmod AP,Yu
R1290 T4665 T4657 punct ", ",Yu
R1291 T4666 T4657 nmod contribution,Yu
R1292 T4667 T4657 nmod to,Yu
R1293 T4668 T4657 nmod GUDMAP,Yu
R1294 T4669 T4657 punct ", ",Yu
R1295 T4670 T4657 punct ),Yu
R1296 T4671 T4642 punct .,used
R1297 T4673 T4674 prep In,used
R1298 T4675 T4676 det this,report
R1299 T4676 T4673 pobj report,In
R1300 T4677 T4674 punct ", ",used
R1301 T4678 T4674 nsubj we,used
R1302 T4679 T4674 dobj immunofluorescence,used
R1303 T4680 T4681 aux to,define
R1304 T4681 T4674 advcl define,used
R1305 T4682 T4681 advmod better,define
R1306 T4683 T4684 det the,patterns
R1307 T4684 T4681 dobj patterns,define
R1308 T4685 T4684 compound expression,patterns
R1309 T4686 T4684 prep of,patterns
R1310 T4687 T4688 det the,genes
R1311 T4688 T4686 pobj genes,of
R1312 T4689 T4688 nmod Pygo1,genes
R1313 T4690 T4689 cc and,Pygo1
R1314 T4691 T4689 conj Pygo2,Pygo1
R1315 T4692 T4684 prep in,patterns
R1316 T4693 T4694 det the,kidney
R1317 T4694 T4692 pobj kidney,in
R1318 T4695 T4694 amod developing,kidney
R1319 T4696 T4674 punct .,used
R1320 T4698 T4699 det Both,genes
R1321 T4699 T4700 nsubjpass genes,expressed
R1322 T4701 T4700 auxpass were,expressed
R1323 T4702 T4700 advmod widely,expressed
R1324 T4703 T4700 punct ", ",expressed
R1325 T4704 T4700 advcl showing,expressed
R1326 T4705 T4706 amod nuclear,localization
R1327 T4706 T4704 dobj localization,showing
R1328 T4707 T4706 prep of,localization
R1329 T4708 T4709 amod encoded,proteins
R1330 T4709 T4707 pobj proteins,of
R1331 T4710 T4706 prep in,localization
R1332 T4711 T4712 det the,bud
R1333 T4712 T4710 pobj bud,in
R1334 T4713 T4712 amod ureteric,bud
R1335 T4714 T4712 punct ", ",bud
R1336 T4715 T4716 compound capping,mesenchyme
R1337 T4716 T4712 conj mesenchyme,bud
R1338 T4717 T4716 punct ", ",mesenchyme
R1339 T4718 T4716 cc and,mesenchyme
R1340 T4719 T4720 amod stromal,cells
R1341 T4720 T4716 conj cells,mesenchyme
R1342 T4721 T4722 punct (,Figure
R1343 T4722 T4700 parataxis Figure,expressed
R1344 T4723 T4722 nummod 2,Figure
R1345 T4724 T4722 punct ),Figure
R1346 T4725 T4700 punct .,expressed
R1347 T4727 T4728 amod Raised,expression
R1348 T4728 T4729 nsubjpass expression,seen
R1349 T4730 T4728 prep of,expression
R1350 T4731 T4730 pobj Pygo1,of
R1351 T4732 T4730 punct ", ",of
R1352 T4733 T4730 cc and,of
R1353 T4734 T4735 prep to,of
R1354 T4735 T4730 conj of,of
R1355 T4736 T4737 det a,degree
R1356 T4737 T4734 pobj degree,to
R1357 T4738 T4737 amod lesser,degree
R1358 T4739 T4735 pobj Pygo2,of
R1359 T4740 T4729 punct ", ",seen
R1360 T4741 T4729 auxpass was,seen
R1361 T4742 T4729 prep in,seen
R1362 T4743 T4744 amod stromal,cells
R1363 T4744 T4742 pobj cells,in
R1364 T4745 T4729 punct ", ",seen
R1365 T4746 T4729 cc and,seen
R1366 T4747 T4748 amod significant,staining
R1367 T4748 T4750 nsubjpass staining,detected
R1368 T4749 T4748 amod nuclear,staining
R1369 T4750 T4729 conj detected,seen
R1370 T4751 T4750 auxpass was,detected
R1371 T4752 T4750 prep in,detected
R1372 T4753 T4754 advmod essentially,cells
R1373 T4754 T4752 pobj cells,in
R1374 T4755 T4754 det all,cells
R1375 T4756 T4754 prep of,cells
R1376 T4757 T4758 det the,kidney
R1377 T4758 T4756 pobj kidney,of
R1378 T4759 T4758 amod developing,kidney
R1379 T4760 T4750 prep for,detected
R1380 T4761 T4762 det both,proteins
R1381 T4762 T4760 pobj proteins,for
R1382 T4763 T4750 punct .,detected
R1387 T5653 T5654 amod Confocal,analysis
R1388 T5655 T5654 prep of,analysis
R1389 T5656 T5657 compound Pygo1,Pygo2
R1390 T5657 T5659 compound Pygo2,mutant
R1391 T5658 T5657 punct /,Pygo2
R1392 T5659 T5660 compound mutant,kidneys
R1393 T5660 T5655 pobj kidneys,of
R1394 T5662 T5663 amod Histological,examination
R1395 T5663 T5664 nsubj examination,reveal
R1396 T5665 T5663 prep of,examination
R1397 T5666 T5667 npadvmod Pygo2,null
R1398 T5667 T5668 amod null,kidneys
R1399 T5668 T5665 pobj kidneys,of
R1400 T5669 T5667 cc and,null
R1401 T5670 T5671 compound Pygo1,Pygo2
R1402 T5671 T5673 npadvmod Pygo2,null
R1403 T5672 T5671 punct /,Pygo2
R1404 T5673 T5667 conj null,null
R1405 T5674 T5673 amod double,null
R1406 T5675 T5673 punct -,null
R1407 T5676 T5668 compound mutant,kidneys
R1408 T5677 T5664 aux did,reveal
R1409 T5678 T5664 neg not,reveal
R1410 T5679 T5680 det any,abnormalities
R1411 T5680 T5664 dobj abnormalities,reveal
R1412 T5681 T5680 prep in,abnormalities
R1413 T5682 T5681 pobj nephrogenesis,in
R1414 T5683 T5684 punct (,shown
R1415 T5684 T5664 parataxis shown,reveal
R1416 T5685 T5684 nsubj data,shown
R1417 T5686 T5684 neg not,shown
R1418 T5687 T5684 punct ),shown
R1419 T5688 T5664 punct .,reveal
R1420 T5690 T5691 amod Confocal,analysis
R1421 T5691 T5692 nsubjpass analysis,performed
R1422 T5693 T5692 auxpass was,performed
R1423 T5694 T5692 advmod therefore,performed
R1424 T5695 T5696 aux to,characterize
R1425 T5696 T5692 advcl characterize,performed
R1426 T5697 T5698 amod renal,development
R1427 T5698 T5696 dobj development,characterize
R1428 T5699 T5698 prep in,development
R1429 T5700 T5701 nmod E18.5,kidneys
R1430 T5701 T5699 pobj kidneys,in
R1431 T5702 T5703 compound Pygo1,Pygo2
R1432 T5703 T5705 npadvmod Pygo2,null
R1433 T5704 T5703 punct /,Pygo2
R1434 T5705 T5701 amod null,kidneys
R1435 T5706 T5707 advmod more,precisely
R1436 T5707 T5696 advmod precisely,characterize
R1437 T5708 T5709 punct (,Figure
R1438 T5709 T5696 parataxis Figure,characterize
R1439 T5710 T5709 nummod 3,Figure
R1440 T5711 T5709 punct ),Figure
R1441 T5712 T5692 punct .,performed
R1442 T5714 T5715 nmod Wt1,antibodies
R1443 T5715 T5724 nsubj antibodies,stain
R1444 T5716 T5717 punct (,red
R1445 T5717 T5714 parataxis red,Wt1
R1446 T5718 T5717 punct ),red
R1447 T5719 T5714 cc and,Wt1
R1448 T5720 T5714 conj Cited1,Wt1
R1449 T5721 T5722 punct (,red
R1450 T5722 T5720 parataxis red,Cited1
R1451 T5723 T5722 punct ),red
R1452 T5725 T5715 appos both,antibodies
R1453 T5726 T5727 det the,mesenchyme
R1454 T5727 T5724 dobj mesenchyme,stain
R1455 T5728 T5727 amod capping,mesenchyme
R1456 T5729 T5727 amod metanephric,mesenchyme
R1457 T5730 T5724 prep around,stain
R1458 T5731 T5732 det the,tips
R1459 T5732 T5730 pobj tips,around
R1460 T5733 T5734 amod ureteric,bud
R1461 T5734 T5732 compound bud,tips
R1462 T5735 T5736 punct [,17
R1463 T5736 T5724 parataxis 17,stain
R1464 T5737 T5736 punct ],17
R1465 T5738 T5724 punct .,stain
R1466 T5740 T5741 compound WT1,antibody
R1467 T5741 T5742 nsubj antibody,stains
R1468 T5743 T5742 advmod also,stains
R1469 T5744 T5745 amod renal,vesicles
R1470 T5745 T5742 dobj vesicles,stains
R1471 T5746 T5745 cc and,vesicles
R1472 T5747 T5748 amod glomerular,anlage
R1473 T5748 T5745 conj anlage,vesicles
R1474 T5749 T5742 punct .,stains
R1475 T5751 T5752 nsubjpass Antibodies,used
R1476 T5753 T5751 prep to,Antibodies
R1477 T5754 T5753 pobj Cdh1,to
R1478 T5755 T5754 punct ", ",Cdh1
R1479 T5756 T5757 advmod also,known
R1480 T5757 T5754 acl known,Cdh1
R1481 T5758 T5757 prep as,known
R1482 T5759 T5760 compound E,cadherin
R1514 T5792 T5790 punct (,biflorus
R1515 T5793 T5790 appos DBA,biflorus
R1516 T5794 T5791 punct ),lectin
R1517 T5796 T5797 punct [,16
R1518 T5797 T5791 parataxis 16,lectin
R1519 T5798 T5797 punct ],16
R1520 T5799 T5795 auxpass was,used
R1521 T5800 T5801 aux to,stain
R1522 T5801 T5795 advcl stain,used
R1523 T5802 T5801 advmod selectively,stain
R1524 T5803 T5804 amod ureteric,bud
R1525 T5804 T5805 npadvmod bud,derived
R1526 T5805 T5807 amod derived,structures
R1527 T5806 T5805 punct -,derived
R1528 T5807 T5801 dobj structures,stain
R1529 T5808 T5809 punct [,19
R1530 T5809 T5801 parataxis 19,stain
R1531 T5810 T5809 punct ],19
R1532 T5811 T5795 punct .,used
R1557 T5861 T5858 punct ", ",Table
R1558 T5862 T5858 nummod 2,Table
R1559 T5863 T5858 punct ),Table
R1560 T5864 T5838 punct .,vealed
R1561 T5866 T5867 advmod Nevertheless,underwent
R1562 T5868 T5867 punct ", ",underwent
R1563 T5869 T5870 det the,mesenchyme
R1564 T5870 T5867 nsubj mesenchyme,underwent
R1565 T5871 T5870 nmod mutant,mesenchyme
R1566 T5872 T5870 amod metanephric,mesenchyme
R1567 T5873 T5874 advmod relatively,normal
R1568 T5874 T5875 amod normal,nephrogenesis
R1569 T5875 T5867 dobj nephrogenesis,underwent
R1570 T5876 T5867 punct .,underwent
R1571 T5878 T5879 npadvmod Cdh1,staining
R1572 T5879 T5881 amod staining,nephrons
R1573 T5880 T5879 punct -,staining
R1574 T5881 T5882 nsubjpass nephrons,identified
R1575 T5883 T5884 punct (,blue
R1576 T5884 T5881 parataxis blue,nephrons
R1577 T5885 T5884 punct ),blue
R1578 T5886 T5882 auxpass were,identified
R1579 T5887 T5882 advcl connecting,identified
R1580 T5888 T5887 prep to,connecting
R1581 T5889 T5890 det the,tips
R1582 T5890 T5888 pobj tips,to
R1583 T5891 T5892 amod ureteric,bud
R1584 T5892 T5890 compound bud,tips
R1585 T5893 T5894 punct [,16
R1586 T5894 T5887 parataxis 16,connecting
R1587 T5895 T5894 punct ],16
R1588 T5896 T5887 cc and,connecting
R1589 T5897 T5887 conj extending,connecting
R1590 T5898 T5897 prep into,extending
R1591 T5899 T5900 det the,medulla
R1592 T5900 T5898 pobj medulla,into
R1593 T5901 T5900 prep of,medulla
R1594 T5902 T5903 det the,kidney
R1595 T5903 T5901 pobj kidney,of
R1596 T5904 T5897 punct ", ",extending
R1597 T5905 T5906 mark as,normal
R1598 T5906 T5897 advcl normal,extending
R1599 T5907 T5882 punct .,identified
R1600 T5909 T5910 amod Intermediate,structures
R1601 T5910 T5911 nsubj structures,appeared
R1602 T5912 T5910 prep of,structures
R1603 T5913 T5912 pobj nephrogenesis,of
R1604 T5914 T5910 punct ", ",structures
R1605 T5915 T5910 prep including,structures
R1606 T5916 T5917 amod renal,vesicles
R1607 T5917 T5915 pobj vesicles,including
R1608 T5918 T5917 punct ", ",vesicles
R1609 T5919 T5920 npadvmod comma,shaped
R1610 T5920 T5922 amod shaped,bodies
R1611 T5921 T5920 punct -,shaped
R1612 T5922 T5917 conj bodies,vesicles
R1613 T5923 T5922 punct ", ",bodies
R1614 T5924 T5922 cc and,bodies
R1615 T5925 T5926 npadvmod S,shaped
R1616 T5926 T5928 amod shaped,bodies
R1617 T5927 T5926 punct -,shaped
R1618 T5928 T5922 conj bodies,bodies
R1619 T5929 T5911 oprd normal,appeared
R1620 T5930 T5911 punct .,appeared
R1621 T5933 T5934 amod Confocal,analysis
R1654 T5974 T5970 compound Pygo2,allele
R1655 T5975 T5976 punct (,Figure
R1656 T5976 T5944 parataxis Figure,were
R1657 T5977 T5976 nummod 3,Figure
R1658 T5978 T5976 punct ),Figure
R1659 T5979 T5942 punct .,howed
R1660 T5981 T5982 prep In,had
R1661 T5983 T5981 pobj addition,In
R1662 T5984 T5982 punct ", ",had
R1663 T5985 T5986 det the,kidneys
R1664 T5986 T5982 nsubj kidneys,had
R1665 T5987 T5988 compound Pygo1,Pygo2
R1666 T5988 T5990 npadvmod Pygo2,homozygous
R1667 T5989 T5988 punct /,Pygo2
R1668 T5990 T5986 amod homozygous,kidneys
R1669 T5991 T5990 amod double,homozygous
R1670 T5992 T5990 punct -,homozygous
R1671 T5993 T5986 compound mutant,kidneys
R1672 T5994 T5982 advmod also,had
R1673 T5995 T5996 det a,decrease
R1674 T5996 T5982 dobj decrease,had
R1675 T5997 T5996 prep of,decrease
R1676 T5998 T5999 advmod approximately,25
R1677 T5999 T6000 nummod 25,%
R1678 T6000 T5997 pobj %,of
R1679 T6001 T5996 prep in,decrease
R1680 T6002 T6003 det the,number
R1681 T6003 T6001 pobj number,in
R1682 T6004 T6003 prep of,number
R1683 T6005 T6006 amod ureteric,bud
R1684 T6006 T6007 compound bud,tips
R1685 T6007 T6004 pobj tips,of
R1686 T6008 T6007 prep per,tips
R1687 T6009 T6008 pobj area,per
R1688 T6010 T6003 prep compared,number
R1689 T6011 T6010 prep with,compared
R1690 T6012 T6011 pobj littermates,with
R1691 T6013 T6012 prep with,littermates
R1692 T6014 T6015 advmod at,one
R1693 T6015 T6017 nummod one,copy
R1694 T6016 T6015 advmod least,one
R1695 T6017 T6013 pobj copy,with
R1696 T6018 T6019 amod wild,type
R1697 T6019 T6017 compound type,copy
R1698 T6020 T6019 punct -,type
R1699 T6021 T6017 prep of,copy
R1700 T6022 T6021 pobj Pygo2,of
R1701 T6023 T6024 punct (,Table
R1702 T6024 T5996 parataxis Table,decrease
R1703 T6025 T6024 nummod 2,Table
R1704 T6026 T6024 punct ),Table
R1705 T6027 T5982 punct .,had
R1706 T6029 T6030 det No,difference
R1707 T6030 T6032 nsubjpass difference,seen
R1708 T6031 T6030 amod significant,difference
R1709 T6033 T6030 prep in,difference
R1710 T6034 T6035 amod ureteric,bud
R1711 T6035 T6036 compound bud,tip
R1712 T6036 T6038 compound tip,density
R1713 T6037 T6036 punct -,tip
R1714 T6038 T6033 pobj density,in
R1715 T6039 T6032 auxpass was,seen
R1716 T6040 T6032 prep between,seen
R1717 T6041 T6042 nmod Pygo2,embryos
R1718 T6042 T6040 pobj embryos,between
R1719 T6043 T6041 punct +,Pygo2
R1720 T6044 T6041 punct /,Pygo2
R1721 T6045 T6041 punct -,Pygo2
R1722 T6046 T6041 cc and,Pygo2
R1723 T6047 T6041 conj Pygo2,Pygo2
R1724 T6048 T6047 punct +,Pygo2
R1725 T6049 T6047 punct /,Pygo2
R1726 T6050 T6047 punct +,Pygo2
R1727 T6051 T6052 punct (,0.33
R1728 T6052 T6032 parataxis 0.33,seen
R1729 T6053 T6052 nsubj P,0.33
R1730 T6054 T6052 punct =,0.33
R1731 T6055 T6052 punct ),0.33
R1732 T6056 T6032 punct .,seen
R1739 T6317 T6318 advmod In,situ
R1740 T6318 T6319 amod situ,hybridization
R1741 T6321 T6322 nsubj We,examined
R1742 T6323 T6322 dobj expression,examined
R1743 T6324 T6323 prep of,expression
R1744 T6325 T6326 nummod three,genes
R1745 T6326 T6324 pobj genes,of
R1746 T6327 T6326 compound Wnt,genes
R1747 T6328 T6323 prep in,expression
R1748 T6329 T6330 compound Pygo,mutants
R1749 T6330 T6328 pobj mutants,in
R1750 T6331 T6322 punct .,examined
R1751 T6333 T6334 nsubjpass Wnt7b,expressed
R1752 T6335 T6334 auxpass is,expressed
R1753 T6336 T6334 prep in,expressed
R1754 T6337 T6338 det the,stalks
R1755 T6338 T6336 pobj stalks,in
R1756 T6339 T6340 punct [,20
R1757 T6340 T6334 parataxis 20,expressed
R1758 T6341 T6340 punct ],20
R1759 T6342 T6334 punct ", ",expressed
R1760 T6343 T6334 conj Wnt11,expressed
R1761 T6344 T6343 prep in,Wnt11
R1762 T6345 T6346 det the,tips
R1763 T6346 T6344 pobj tips,in
R1764 T6347 T6348 punct [,4
R1765 T6348 T6343 parataxis 4,Wnt11
R1766 T6349 T6348 punct ],4
R1767 T6350 T6343 punct ", ",Wnt11
R1768 T6351 T6343 cc and,Wnt11
R1769 T6352 T6343 conj Wnt9b,Wnt11
R1770 T6353 T6352 prep in,Wnt9b
R1771 T6354 T6355 det the,stalks
R1772 T6355 T6353 pobj stalks,in
R1773 T6356 T6353 cc and,in
R1774 T6357 T6358 advmod weakly,in
R1775 T6358 T6353 conj in,in
R1776 T6359 T6360 det the,tips
R1777 T6360 T6358 pobj tips,in
R1778 T6361 T6360 prep of,tips
R1779 T6362 T6363 det the,bud
R1780 T6363 T6361 pobj bud,of
R1781 T6364 T6363 nmod branching,bud
R1782 T6365 T6363 amod ureteric,bud
R1783 T6366 T6367 punct [,2
R1784 T6367 T6352 parataxis 2,Wnt9b
R1785 T6368 T6367 punct ],2
R1786 T6369 T6352 punct .,Wnt9b
R1787 T6371 T6372 det All,genes
R1788 T6372 T6374 nsubj genes,showed
R1789 T6373 T6372 nummod three,genes
R1790 T6375 T6376 amod similar,patterns
R1791 T6376 T6374 dobj patterns,showed
R1792 T6377 T6376 compound expression,patterns
R1793 T6378 T6374 prep in,showed
R1794 T6379 T6380 nmod Pygo2,kidneys
R1795 T6380 T6378 pobj kidneys,in
R1796 T6381 T6379 punct +,Pygo2
R1797 T6382 T6379 punct /,Pygo2
R1798 T6383 T6379 punct +,Pygo2
R1799 T6384 T6379 cc and,Pygo2
R1800 T6385 T6386 nmod Pygo1,Pygo2
R1801 T6386 T6388 nmod Pygo2,mutant
R1802 T6387 T6386 punct /,Pygo2
R1803 T6388 T6379 conj mutant,Pygo2
R1804 T6389 T6388 amod double,mutant
R1805 T6390 T6388 punct -,mutant
R1806 T6391 T6392 punct (,Figure
R1807 T6392 T6374 parataxis Figure,showed
R1808 T6393 T6392 nummod 4,Figure
R1809 T6394 T6392 punct ),Figure
R1810 T6395 T6374 punct .,showed
R1811 T6397 T6398 prep In,confirmed
R1812 T6399 T6397 pobj addition,In
R1813 T6400 T6398 punct ", ",confirmed
R1814 T6401 T6402 det these,patterns
R1815 T6402 T6398 nsubj patterns,confirmed
R1816 T6403 T6404 advmod in,situ
R1817 T6404 T6405 amod situ,hybridization
R1818 T6405 T6402 compound hybridization,patterns
R1819 T6406 T6407 det the,results
R1820 T6407 T6398 dobj results,confirmed
R1821 T6408 T6409 amod confocal,microscopy
R1822 T6409 T6407 compound microscopy,results
R1823 T6410 T6398 punct ", ",confirmed
R1824 T6411 T6398 advcl showing,confirmed
R1825 T6412 T6413 det a,number
R1826 T6413 T6411 dobj number,showing
R1827 T6414 T6413 amod reduced,number
R1828 T6415 T6413 prep of,number
R1829 T6416 T6415 pobj tips,of
R1830 T6417 T6416 punct (,tips
R1831 T6418 T6419 npadvmod Wnt11,positive
R1832 T6419 T6416 amod positive,tips
R1833 T6420 T6419 punct -,positive
R1834 T6421 T6416 punct ),tips
R1835 T6422 T6416 prep per,tips
R1836 T6423 T6424 compound surface,area
R1837 T6424 T6422 pobj area,per
R1838 T6425 T6413 prep in,number
R1839 T6426 T6427 det the,mutants
R1840 T6427 T6425 pobj mutants,in
R1841 T6428 T6429 compound Pygo1,Pygo2
R1842 T6429 T6431 npadvmod Pygo2,homozygous
R1843 T6430 T6429 punct /,Pygo2
R1844 T6431 T6427 amod homozygous,mutants
R1845 T6432 T6431 amod double,homozygous
R1846 T6433 T6431 punct -,homozygous
R1847 T6434 T6398 punct .,confirmed
R1858 T9319 T9320 amod Reduced,signaling
R1859 T9321 T9320 amod canonical,signaling
R1860 T9322 T9320 compound Wnt,signaling
R1861 T9323 T9320 prep in,signaling
R1862 T9324 T9325 compound Pygo1,Pygo2
R1863 T9325 T9327 compound Pygo2,mutant
R1864 T9326 T9325 punct /,Pygo2
R1865 T9327 T9328 compound mutant,mice
R1866 T9328 T9323 pobj mice,in
R1867 T9330 T9331 det The,reporter
R1868 T9331 T9336 nsubjpass reporter,used
R1869 T9332 T9333 compound BAT,gal
R1870 T9333 T9335 compound gal,transgene
R1871 T9334 T9333 punct -,gal
R1872 T9335 T9331 compound transgene,reporter
R1873 T9337 T9331 prep of,reporter
R1875 T9338 T9339 amod canonical,signaling
R1877 T9339 T9337 pobj signaling,of
R1878 T9340 T9339 compound Wnt,signaling
R1879 T9341 T9342 punct [,21
R1880 T9342 T9331 parataxis 21,reporter
R1881 T9343 T9342 punct ],21
R1882 T9344 T9336 auxpass was,used
R1883 T9345 T9346 aux to,examine
R1884 T9346 T9336 advcl examine,used
R1885 T9347 T9346 dobj changes,examine
R1886 T9348 T9347 prep in,changes
R1887 T9349 T9350 compound Wnt,signaling
R1888 T9350 T9348 pobj signaling,in
R1889 T9351 T9347 prep in,changes
R1890 T9352 T9353 det the,mice
R1891 T9353 T9351 pobj mice,in
R1892 T9354 T9353 compound mutant,mice
R1894 T9355 T9336 punct .,used
R1906 T9357 T9358 preconj Both,Pygo2
R1912 T9358 T9359 npadvmod Pygo2,null
R1917 T9359 T9369 amod null,embryos
R1920 T9360 T9358 punct -,Pygo2
R1922 T9436 T9425 prep in,are
R1923 T9437 T9436 pobj some,in
R1924 T9438 T9436 punct ", ",in
R1925 T9361 T9358 punct /,Pygo2
R1926 T9439 T9436 cc but,in
R1927 T9362 T9358 punct -,Pygo2
R1928 T9440 T9439 neg not,but
R1929 T9441 T9436 conj in,in
R1930 T9442 T9441 pobj all,in
R1931 T9443 T9444 amod developing,systems
R1932 T9363 T9358 cc and,Pygo2
R1933 T9444 T9441 pobj systems,in
R1934 T9445 T9423 punct .,suggest
R1935 T9364 T9365 compound Pygo1,Pygo2
R1936 T9365 T9358 conj Pygo2,Pygo2
R1937 T9366 T9365 punct /,Pygo2
R1938 T9453 T9452 compound s,o
R1939 T9367 T9359 amod double,null
R1940 T9368 T9359 punct -,null
R1941 T9369 T9371 nsubj embryos,showed
R1942 T9370 T9369 compound E10.5,embryos
R1943 T9372 T9373 det a,decrease
R1944 T9373 T9371 dobj decrease,showed
R1945 T9374 T9373 prep in,decrease
R1946 T9375 T9376 amod canonical,signaling
R1947 T9376 T9374 pobj signaling,in
R1951 T9377 T9376 compound Wnt,signaling
R1952 T9378 T9379 punct (,Figure
R1953 T9379 T9371 parataxis Figure,showed
R1954 T9380 T9379 nummod 5,Figure
R1955 T9381 T9379 punct ),Figure
R1956 T9382 T9371 punct .,showed
R1957 T9384 T9385 expl There,was
R1958 T9386 T9385 punct ", ",was
R1961 T9387 T9385 advmod however,was
R1965 T9388 T9385 punct ", ",was
R1968 T9389 T9390 npadvmod tissue,specific
R1969 T9390 T9392 amod specific,variability
R1971 T9391 T9390 punct -,specific
R1974 T9392 T9385 attr variability,was
R1978 T9393 T9392 prep in,variability
R1980 T9394 T9395 det the,degree
R1982 T9395 T9393 pobj degree,in
R1983 T9396 T9395 prep of,degree
R1984 T9494 T9495 nsubj results,suggested
R1985 T9397 T9396 pobj reduction,of
R1986 T9496 T9497 mark that,required
R1987 T9497 T9495 ccomp required,suggested
R1988 T9398 T9385 punct ", ",was
R1989 T9498 T9499 det the,gene
R1990 T9499 T9497 nsubjpass gene,required
R1991 T9500 T9499 compound Pygo2,gene
R1992 T9399 T9385 prep with,was
R1993 T9501 T9497 auxpass is,required
R1994 T9502 T9497 prep for,required
R1995 T9503 T9504 amod canonical,signaling
R1996 T9400 T9401 det the,somites
R1997 T9504 T9502 pobj signaling,for
R1998 T9505 T9504 compound Wnt,signaling
R1999 T9401 T9402 nsubj somites,showing
R2000 T9506 T9504 prep in,signaling
R2001 T9507 T9508 det the,duct
R2002 T9508 T9506 pobj duct,in
R2003 T9402 T9399 pcomp showing,with
R2004 T9403 T9402 punct ", ",showing
R2005 T9509 T9508 amod nephric,duct
R2006 T9510 T9495 punct .,suggested
R2007 T9404 T9402 prep for,showing
R2008 T9512 T9513 preconj Both,null
R2009 T9513 T9515 amod null,embryos
R2010 T9405 T9404 pobj example,for
R2011 T9514 T9513 npadvmod Pygo2,null
R2012 T9515 T9524 nsubj embryos,showed
R2013 T9516 T9513 cc and,null
R2014 T9406 T9402 punct ", ",showing
R2015 T9517 T9518 compound Pygo1,Pygo2
R2016 T9518 T9520 npadvmod Pygo2,null
R2017 T9519 T9518 punct /,Pygo2
R2018 T9407 T9408 amod strong,reduction
R2019 T9520 T9513 conj null,null
R2020 T9521 T9520 amod double,null
R2021 T9522 T9520 punct -,null
R2022 T9408 T9402 dobj reduction,showing
R2023 T9523 T9515 compound E10.5,embryos
R2024 T9525 T9526 det an,absence
R2025 T9409 T9402 punct ", ",showing
R2026 T9526 T9524 dobj absence,showed
R2027 T9527 T9526 prep of,absence
R2028 T9528 T9529 compound reporter,expression
R2030 T9529 T9527 pobj expression,of
R2031 T9530 T9526 prep in,absence
R2032 T9531 T9532 det the,duct
R2034 T9532 T9530 pobj duct,in
R2035 T9533 T9532 amod nephric,duct
R2036 T9534 T9524 punct ", ",showed
R2038 T9535 T9536 mark while,showed
R2039 T9536 T9524 advcl showed,showed
R2040 T9537 T9538 compound control,littermates
R2041 T9538 T9536 nsubj littermates,showed
R2042 T9539 T9540 amod strong,expression
R2043 T9540 T9536 dobj expression,showed
R2044 T9541 T9542 punct (,6A
R2045 T9542 T9524 parataxis 6A,showed
R2046 T9543 T9542 compound Figure,6A
R2047 T9544 T9545 punct –,C
R2048 T9545 T9542 prep C,6A
R2049 T9546 T9542 punct ),6A
R2051 T9547 T9524 punct .,showed
R2052 T9549 T9550 prep In,form
R2053 T9551 T9552 compound Pygo1,Pygo2
R2054 T9552 T9554 npadvmod Pygo2,null
R2055 T9553 T9552 punct /,Pygo2
R2056 T9554 T9557 amod null,mutants
R2057 T9555 T9554 amod double,null
R2058 T9556 T9554 punct -,null
R2059 T9557 T9549 pobj mutants,In
R2060 T9558 T9550 punct ", ",form
R2061 T9559 T9560 det the,duct
R2062 T9560 T9550 nsubj duct,form
R2063 T9561 T9560 amod nephric,duct
R2064 T9562 T9550 aux did,form
R2065 T9563 T9550 punct ", ",form
R2066 T9564 T9550 advmod however,form
R2067 T9565 T9550 punct ", ",form
R2068 T9566 T9550 cc and,form
R2069 T9567 T9550 conj give,form
R2070 T9568 T9567 dobj rise,give
R2071 T9569 T9567 prep to,give
R2072 T9570 T9571 det the,outgrowth
R2073 T9571 T9569 pobj outgrowth,to
R2074 T9572 T9573 amod ureteric,bud
R2075 T9573 T9571 compound bud,outgrowth
R2076 T9574 T9571 punct ", ",outgrowth
R2078 T9575 T9576 dep which,showed
R2079 T9576 T9571 relcl showed,outgrowth
R2080 T9577 T9578 amod reduced,expression
R2082 T9579 T9577 cc but,reduced
R2083 T9580 T9579 neg not,but
R2114 T9748 T9717 punct .,showed
R2116 T9750 T9751 amod Homozygous,loss
R2121 T9751 T9752 nsubj loss,had
R2124 T9753 T9751 prep of,loss
R2129 T9754 T9755 det the,gene
R2133 T9755 T9753 pobj gene,of
R2135 T9756 T9755 compound Pygo1,gene
R2136 T9675 T9664 dobj staining,showed
R2138 T9757 T9755 advmod alone,gene
R2139 T9677 T9675 compound gal,staining
R2141 T9679 T9680 punct (,6D
R2142 T9758 T9752 punct ", ",had
R2143 T9680 T9675 parataxis 6D,staining
R2144 T9681 T9680 compound Figure,6D
R2145 T9759 T9752 advmod however,had
R2146 T9682 T9680 punct ),6D
R2147 T9683 T9664 punct ", ",showed
R2148 T9760 T9752 punct ", ",had
R2149 T9684 T9685 mark whereas,showed
R2150 T9685 T9664 advcl showed,showed
R2151 T9761 T9762 det a,effect
R2152 T9686 T9687 det a,kidney
R2153 T9687 T9685 nsubj kidney,showed
R2154 T9688 T9689 compound BAT,gal
R2155 T9689 T9691 npadvmod gal,transgenic
R2156 T9762 T9752 dobj effect,had
R2157 T9690 T9689 punct -,gal
R2158 T9691 T9687 amod transgenic,kidney
R2159 T9692 T9687 prep with,kidney
R2160 T9693 T9694 advmod at,one
R2161 T9694 T9696 nummod one,gene
R2162 T9695 T9694 advmod least,one
R2163 T9763 T9762 amod small,effect
R2164 T9696 T9692 pobj gene,with
R2165 T9697 T9698 amod wild,type
R2166 T9698 T9696 compound type,gene
R2167 T9764 T9762 prep on,effect
R2168 T9699 T9698 punct -,type
R2169 T9700 T9696 compound Pygo2,gene
R2170 T9765 T9766 compound reporter,expression
R2171 T9701 T9702 amod strong,staining
R2172 T9702 T9685 dobj staining,showed
R2173 T9703 T9704 compound X,gal
R2174 T9766 T9764 pobj expression,on
R2175 T9704 T9702 compound gal,staining
R2176 T9705 T9704 punct -,gal
R2177 T9706 T9702 prep in,staining
R2178 T9767 T9768 punct (,6G
R2179 T9707 T9708 det the,tree
R2180 T9708 T9706 pobj tree,in
R2181 T9709 T9708 amod ureteric,tree
R2182 T9768 T9752 parataxis 6G,had
R2183 T9710 T9711 punct (,6E
R2184 T9711 T9702 parataxis 6E,staining
R2185 T9712 T9711 compound Figure,6E
R2186 T9713 T9711 punct ),6E
R2187 T9769 T9768 compound Figure,6G
R2188 T9714 T9664 punct .,showed
R2189 T9770 T9771 punct –,H
R2190 T9716 T9717 prep In,showed
R2191 T9718 T9716 pobj contrast,In
R2192 T9771 T9768 prep H,6G
R2193 T9719 T9717 punct ", ",showed
R2194 T9720 T9721 nmod Pygo1,kidneys
R2195 T9721 T9717 nsubj kidneys,showed
R2196 T9772 T9768 punct ),6G
R2197 T9722 T9720 punct +,Pygo1
R2198 T9723 T9720 punct /,Pygo1
R2199 T9724 T9720 punct -,Pygo1
R2200 T9773 T9752 punct .,had
R2201 T9725 T9720 punct /,Pygo1
R2202 T9726 T9720 appos Pygo2,Pygo1
R2203 T9727 T9726 punct -,Pygo2
R2204 T9775 T9776 amod Homozygous,mutation
R2205 T9728 T9726 punct /,Pygo2
R2206 T9729 T9726 punct -,Pygo2
R2207 T9730 T9721 compound E13.5,kidneys
R2208 T9776 T9777 nsubj mutation,gave
R2209 T9731 T9732 advmod very,weak
R2210 T9732 T9733 amod weak,expression
R2211 T9733 T9717 dobj expression,showed
R2212 T9734 T9733 compound reporter,expression
R2213 T9735 T9736 punct (,6F
R2214 T9736 T9733 parataxis 6F,expression
R2215 T9778 T9776 prep of,mutation
R2216 T9737 T9736 compound Figure,6F
R2217 T9738 T9736 punct ),6F
R2218 T9739 T9717 punct ", ",showed
R2219 T9740 T9717 advcl suggesting,showed
R2220 T9741 T9742 det a,loss
R2221 T9779 T9780 preconj both,genes
R2222 T9742 T9740 dobj loss,suggesting
R2223 T9743 T9742 amod significant,loss
R2224 T9744 T9742 prep of,loss
R2225 T9780 T9778 pobj genes,of
R2226 T9745 T9746 amod canonical,signaling
R2227 T9746 T9744 pobj signaling,of
R2228 T9781 T9780 det the,genes
R2229 T9747 T9746 compound Wnt,signaling
R2230 T9782 T9780 nmod Pygo1,genes
R2231 T9783 T9782 cc and,Pygo1
R2232 T9784 T9782 conj Pygo2,Pygo1
R2233 T9853 T9855 amod homozygous,mutants
R2234 T9785 T9786 det a,reduction
R2235 T9854 T9853 punct -,homozygous
R2236 T9855 T9856 nsubj mutants,showed
R2237 T9786 T9777 dobj reduction,gave
R2238 T9856 T9831 conj showed,was
R2239 T9857 T9856 dobj loss,showed
R2240 T9787 T9788 advmod more,dramatic
R2241 T9858 T9857 prep of,loss
R2242 T9859 T9860 compound X,gal
R2243 T9788 T9786 amod dramatic,reduction
R2244 T9860 T9862 compound gal,staining
R2245 T9861 T9860 punct -,gal
R2246 T9862 T9858 pobj staining,of
R2247 T9789 T9786 prep of,reduction
R2248 T9863 T9856 prep in,showed
R2249 T9864 T9865 det the,ducts
R2250 T9865 T9863 pobj ducts,in
R2251 T9790 T9791 compound BAT,gal
R2252 T9866 T9865 amod paramesonephric,ducts
R2253 T9867 T9868 punct (,6K
R2254 T9868 T9865 parataxis 6K,ducts
R2255 T9791 T9793 compound gal,expression
R2256 T9869 T9868 compound Figure,6K
R2257 T9870 T9868 punct ),6K
R2258 T9871 T9856 punct ", ",showed
R2259 T9792 T9791 punct -,gal
R2260 T9872 T9873 mark whereas,showed
R2261 T9873 T9856 advcl showed,showed
R2262 T9793 T9789 pobj expression,of
R2263 T9874 T9875 nmod Pygo1,mice
R2264 T9875 T9873 nsubj mice,showed
R2265 T9876 T9874 punct -,Pygo1
R2266 T9877 T9874 punct /,Pygo1
R2267 T9878 T9874 punct -,Pygo1
R2268 T9879 T9874 punct /,Pygo1
R2269 T9794 T9786 prep than,reduction
R2270 T9880 T9874 appos Pygo2,Pygo1
R2271 T9881 T9880 punct +,Pygo2
R2272 T9882 T9880 punct /,Pygo2
R2273 T9883 T9880 punct -,Pygo2
R2274 T9795 T9794 pobj loss,than
R2275 T9884 T9874 cc and,Pygo1
R2276 T9885 T9874 conj Pygo1,Pygo1
R2277 T9796 T9795 prep of,loss
R2278 T9886 T9885 punct +,Pygo1
R2279 T9887 T9885 punct /,Pygo1
R2280 T9888 T9885 punct -,Pygo1
R2281 T9797 T9796 pobj Pygo2,of
R2282 T9889 T9885 punct /,Pygo1
R2283 T9890 T9885 appos Pygo2,Pygo1
R2284 T9891 T9890 punct +,Pygo2
R2285 T9892 T9890 punct /,Pygo2
R2286 T9798 T9795 advmod alone,loss
R2287 T9893 T9890 punct -,Pygo2
R2288 T9894 T9895 amod normal,levels
R2289 T9895 T9873 dobj levels,showed
R2290 T9799 T9800 punct (,L
R2291 T9896 T9895 prep of,levels
R2292 T9897 T9898 compound BAT,gal
R2293 T9898 T9900 compound gal,expression
R2294 T9800 T9786 parataxis L,reduction
R2295 T9899 T9898 punct -,gal
R2296 T9900 T9896 pobj expression,of
R2297 T9901 T9902 punct (,J
R2298 T9801 T9800 nmod Figure,L
R2299 T9902 T9873 parataxis J,showed
R2300 T9903 T9902 nmod Figure,J
R2301 T9802 T9800 nmod 6F,L
R2302 T9904 T9902 nmod 6G,J
R2303 T9905 T9902 punct ", ",J
R2304 T9906 T9902 nmod H,J
R2305 T9803 T9800 punct ", ",L
R2306 T9907 T9902 punct ", ",J
R2307 T9908 T9902 punct ),J
R2308 T9909 T9856 punct .,showed
R2309 T9804 T9800 punct ),L
R2310 T9911 T9912 compound BAT,gal
R2311 T9912 T9914 compound gal,reporter
R2312 T9913 T9912 punct -,gal
R2313 T9805 T9777 punct .,gave
R2314 T9914 T9915 compound reporter,analysis
R2315 T9915 T9916 nsubj analysis,identified
R2316 T9917 T9915 prep of,analysis
R2317 T9918 T9919 det the,mutants
R2318 T9807 T9808 det The,genes
R2319 T9919 T9917 pobj mutants,of
R2320 T9920 T9919 compound Pygo,mutants
R2321 T9921 T9915 prep at,analysis
R2322 T9922 T9923 det a,stage
R2323 T9923 T9921 pobj stage,at
R2324 T9924 T9923 advmod later,stage
R2325 T9808 T9812 nsubjpass genes,required
R2326 T9925 T9923 amod developmental,stage
R2327 T9926 T9923 punct ", ",stage
R2328 T9927 T9923 appos E18.5,stage
R2329 T9809 T9808 nmod Pygo1,genes
R2330 T9928 T9916 punct ", ",identified
R2331 T9929 T9916 advmod also,identified
R2332 T9930 T9931 det a,decrease
R2333 T9810 T9809 cc and,Pygo1
R2334 T9811 T9809 conj Pygo2,Pygo1
R2335 T9931 T9916 dobj decrease,identified
R2336 T9932 T9931 amod significant,decrease
R2337 T9813 T9812 auxpass were,required
R2338 T9933 T9931 prep in,decrease
R2339 T9934 T9935 amod canonical,signaling
R2340 T9935 T9933 pobj signaling,in
R2341 T9936 T9935 compound Wnt,signaling
R2342 T9937 T9931 prep in,decrease
R2343 T9814 T9812 advmod also,required
R2344 T9938 T9939 det the,branches
R2345 T9939 T9937 pobj branches,in
R2346 T9815 T9812 prep for,required
R2347 T9940 T9939 amod cortical,branches
R2348 T9941 T9939 amod ureteric,branches
R2349 T9942 T9939 cc and,branches
R2350 T9816 T9817 compound BAT,gal
R2351 T9943 T9944 amod renal,pelvis
R2352 T9944 T9939 conj pelvis,branches
R2353 T9945 T9939 prep of,branches
R2354 T9817 T9819 compound gal,reporter
R2355 T9946 T9947 det the,kidney
R2356 T9947 T9945 pobj kidney,of
R2357 T9948 T9947 amod developing,kidney
R2358 T9818 T9817 punct -,gal
R2359 T9949 T9950 punct (,6M
R2360 T9950 T9916 parataxis 6M,identified
R2361 T9951 T9950 compound Figure,6M
R2362 T9819 T9820 compound reporter,expression
R2363 T9952 T9953 punct –,O
R2364 T9953 T9950 prep O,6M
R2365 T9820 T9815 pobj expression,for
R2366 T9954 T9950 punct ),6M
R2367 T9955 T9916 punct .,identified
R2368 T9957 T9958 amod Cortical,staining
R2369 T9821 T9820 prep in,expression
R2370 T9822 T9823 det the,ducts
R2371 T9958 T9962 nsubjpass staining,seen
R2372 T9823 T9821 pobj ducts,in
R2373 T9959 T9960 compound X,gal
R2374 T9960 T9958 compound gal,staining
R2375 T9961 T9960 punct -,gal
R2376 T9824 T9823 amod paramesonephric,ducts
R2377 T9963 T9962 auxpass was,seen
R2378 T9964 T9962 prep in,seen
R2379 T9825 T9826 punct (,Mullerian
R2380 T9965 T9966 det the,branches
R2381 T9966 T9964 pobj branches,in
R2382 T9967 T9966 amod ureteric,branches
R2383 T9826 T9824 parataxis Mullerian,paramesonephric
R2384 T9968 T9966 prep of,branches
R2385 T9969 T9970 det a,kidney
R2386 T9970 T9968 pobj kidney,of
R2387 T9827 T9826 punct ),Mullerian
R2388 T9971 T9970 nmod Pygo1,kidney
R2389 T9972 T9971 punct +,Pygo1
R2390 T9973 T9971 punct /,Pygo1
R2391 T9828 T9812 punct .,required
R2392 T9974 T9971 punct -,Pygo1
R2393 T9975 T9971 punct /,Pygo1
R2394 T9976 T9971 appos Pygo2,Pygo1
R2395 T9830 T9831 prep In,was
R2396 T9977 T9976 punct +,Pygo2
R2397 T9978 T9976 punct /,Pygo2
R2398 T9979 T9976 punct -,Pygo2
R2399 T9980 T9981 punct (,left
R2400 T9981 T9962 parataxis left,seen
R2401 T9832 T9833 nmod Pygo2,mice
R2402 T9982 T9983 compound Figure,6M
R2403 T9983 T9981 dep 6M,left
R2404 T9984 T9981 punct ", ",left
R2405 T9985 T9981 punct ),left
R2406 T9833 T9830 pobj mice,In
R2407 T9986 T9962 punct ", ",seen
R2408 T9987 T9962 cc but,seen
R2409 T9988 T9962 conj was,seen
R2410 T9834 T9832 punct -,Pygo2
R2411 T9989 T9990 advmod completely,absent
R2412 T9990 T9988 acomp absent,was
R2413 T9991 T9988 prep in,was
R2414 T9835 T9832 punct /,Pygo2
R2415 T9992 T9993 det the,cortex
R2416 T9836 T9832 punct -,Pygo2
R2417 T9993 T9991 pobj cortex,in
R2418 T9837 T9831 punct ", ",was
R2419 T9994 T9993 prep of,cortex
R2420 T9995 T9996 det a,kidney
R2421 T9996 T9994 pobj kidney,of
R2422 T9997 T9996 nmod Pygo1,kidney
R2423 T9838 T9831 expl there,was
R2424 T9998 T9997 punct +,Pygo1
R2425 T9999 T9997 punct /,Pygo1
R2426 T10000 T9997 punct -,Pygo1
R2427 T9839 T9840 det a,loss
R2428 T10001 T9997 punct /,Pygo1
R2429 T10002 T9997 appos Pygo2,Pygo1
R2430 T10003 T10002 punct -,Pygo2
R2431 T9840 T9831 attr loss,was
R2432 T10004 T10002 punct /,Pygo2
R2433 T10005 T10002 punct -,Pygo2
R2434 T10006 T10007 punct (,right
R2435 T9841 T9840 amod significant,loss
R2436 T10007 T9988 parataxis right,was
R2437 T10008 T10009 compound Figure,6M
R2438 T10009 T10007 dep 6M,right
R2439 T9842 T9840 prep of,loss
R2440 T10010 T10007 punct ", ",right
R2441 T10011 T10007 punct ),right
R2442 T10012 T9962 punct .,seen
R2443 T9843 T9844 compound reporter,expression
R2444 T10014 T10015 nsubj Bisection,revealed
R2445 T9844 T9842 pobj expression,of
R2446 T10016 T10017 det a,loss
R2447 T9845 T9846 punct (,shown
R2448 T9846 T9831 parataxis shown,was
R2449 T10017 T10015 dobj loss,revealed
R2450 T10018 T10017 amod significant,loss
R2451 T10019 T10017 prep of,loss
R2452 T9847 T9846 nsubj data,shown
R2453 T10020 T10021 compound X,gal
R2454 T10021 T10023 npadvmod gal,staining
R2455 T10022 T10021 punct -,gal
R2456 T9848 T9846 neg not,shown
R2457 T10023 T10024 amod staining,cells
R2458 T10024 T10019 pobj cells,of
R2459 T9849 T9846 punct ),shown
R2460 T10025 T10017 prep in,loss
R2461 T10026 T10027 det the,ducts
R2462 T10027 T10025 pobj ducts,in
R2463 T9850 T9831 punct ", ",was
R2464 T10028 T10027 amod collecting,ducts
R2465 T10029 T10027 cc and,ducts
R2466 T10030 T10031 amod renal,pelvis
R2467 T10031 T10027 conj pelvis,ducts
R2468 T9851 T9831 cc and,was
R2469 T10032 T10027 prep of,ducts
R2470 T10033 T10034 det the,kidney
R2471 T10034 T10032 pobj kidney,of
R2472 T10035 T10036 npadvmod Pygo2,null
R2473 T10036 T10034 amod null,kidney
R2474 T9852 T9853 amod double,homozygous
R2475 T10037 T10017 prep compared,loss
R2476 T10038 T10037 prep with,compared
R2477 T10039 T10040 compound control,littermates
R2478 T10040 T10038 pobj littermates,with
R2479 T10041 T10042 punct (,6N
R2480 T10063 T10064 punct (,left
R2481 T10042 T10015 parataxis 6N,revealed
R2482 T10043 T10042 compound Figure,6N
R2483 T10044 T10042 punct ),6N
R2484 T10064 T10053 parataxis left,Pygo1
R2485 T10045 T10015 punct .,revealed
R2486 T10047 T10048 nmod Side,comparison
R2487 T10048 T10051 nsubj comparison,suggested
R2488 T10065 T10066 compound Figure,6O
R2489 T10049 T10047 prep by,Side
R2490 T10050 T10049 pobj side,by
R2491 T10066 T10064 dep 6O,left
R2492 T10052 T10048 prep of,comparison
R2493 T10053 T10054 nmod Pygo1,kidneys
R2494 T10067 T10064 punct ", ",left
R2495 T10068 T10064 punct ),left
R2496 T10054 T10052 pobj kidneys,of
R2497 T10055 T10053 punct +,Pygo1
R2498 T10069 T10053 punct ", ",Pygo1
R2499 T10056 T10053 punct /,Pygo1
R2500 T10057 T10053 punct +,Pygo1
R2501 T10058 T10053 punct /,Pygo1
R2502 T10070 T10053 conj Pygo1,Pygo1
R2503 T10059 T10053 appos Pygo2,Pygo1
R2504 T10060 T10059 punct +,Pygo2
R2505 T10061 T10059 punct /,Pygo2
R2506 T10071 T10070 punct -,Pygo1
R2507 T10062 T10059 punct -,Pygo2
R2508 T10072 T10070 punct /,Pygo1
R2509 T10073 T10070 punct -,Pygo1
R2510 T10168 T10166 prep of,Loss
R2511 T10169 T10170 det the,gene
R2512 T10074 T10070 punct /,Pygo1
R2513 T10170 T10168 pobj gene,of
R2514 T10171 T10170 compound Pygo2,gene
R2515 T10172 T10166 punct (,Loss
R2516 T10075 T10070 appos Pygo2,Pygo1
R2517 T10173 T10166 appos Pygo1,Loss
R2518 T10174 T10173 punct +,Pygo1
R2519 T10076 T10075 punct +,Pygo2
R2520 T10175 T10173 punct /,Pygo1
R2521 T10176 T10173 punct -,Pygo1
R2522 T10177 T10173 punct /,Pygo1
R2523 T10077 T10075 punct /,Pygo2
R2524 T10178 T10173 appos Pygo2,Pygo1
R2525 T10179 T10178 punct -,Pygo2
R2526 T10180 T10178 punct /,Pygo2
R2527 T10181 T10178 punct -,Pygo2
R2528 T10182 T10173 cc and,Pygo1
R2529 T10078 T10075 punct -,Pygo2
R2530 T10183 T10173 conj Pygo1,Pygo1
R2531 T10184 T10183 punct -,Pygo1
R2532 T10079 T10080 punct (,middle
R2533 T10080 T10070 parataxis middle,Pygo1
R2534 T10185 T10183 punct /,Pygo1
R2535 T10186 T10183 punct -,Pygo1
R2536 T10187 T10183 punct /,Pygo1
R2537 T10081 T10082 compound Figure,6O
R2538 T10188 T10183 appos Pygo2,Pygo1
R2539 T10189 T10188 punct -,Pygo2
R2540 T10082 T10080 dep 6O,middle
R2541 T10190 T10188 punct /,Pygo2
R2542 T10191 T10188 punct -,Pygo2
R2543 T10192 T10167 punct ),gave
R2544 T10083 T10080 punct ", ",middle
R2545 T10193 T10194 amod greater,90
R2546 T10194 T10196 nummod 90,%
R2547 T10084 T10080 punct ),middle
R2548 T10195 T10194 quantmod than,90
R2549 T10196 T10197 compound %,reduction
R2550 T10197 T10167 dobj reduction,gave
R2551 T10085 T10070 punct ", ",Pygo1
R2552 T10198 T10197 prep in,reduction
R2553 T10199 T10200 compound BAT,gal
R2554 T10200 T10202 compound gal,expression
R2555 T10086 T10070 cc and,Pygo1
R2556 T10201 T10200 punct -,gal
R2557 T10202 T10198 pobj expression,in
R2558 T10203 T10167 punct .,gave
R2559 T10087 T10070 conj Pygo1,Pygo1
R2560 T10205 T10206 nsubj Loss,result
R2561 T10088 T10087 punct -,Pygo1
R2562 T10207 T10205 prep of,Loss
R2563 T10208 T10207 pobj Pygo1,of
R2564 T10209 T10205 advmod alone,Loss
R2565 T10089 T10087 punct /,Pygo1
R2566 T10210 T10205 punct (,Loss
R2567 T10211 T10205 appos Pygo1,Loss
R2568 T10212 T10211 punct -,Pygo1
R2569 T10090 T10087 punct -,Pygo1
R2570 T10213 T10211 punct /,Pygo1
R2571 T10214 T10211 punct -,Pygo1
R2572 T10215 T10211 punct /,Pygo1
R2573 T10216 T10211 appos Pygo2,Pygo1
R2574 T10091 T10087 punct /,Pygo1
R2575 T10217 T10216 punct +,Pygo2
R2576 T10218 T10216 punct /,Pygo2
R2577 T10219 T10216 punct +,Pygo2
R2578 T10220 T10206 punct ),result
R2579 T10221 T10206 aux did,result
R2580 T10222 T10206 neg not,result
R2581 T10092 T10087 appos Pygo2,Pygo1
R2582 T10223 T10206 prep in,result
R2583 T10224 T10225 det a,change
R2584 T10093 T10092 punct -,Pygo2
R2585 T10225 T10223 pobj change,in
R2586 T10226 T10225 amod significant,change
R2587 T10227 T10206 punct .,result
R2588 T10094 T10092 punct /,Pygo2
R2589 T10229 T10230 advmod Interestingly,showed
R2590 T10095 T10092 punct -,Pygo2
R2591 T10231 T10230 punct ", ",showed
R2592 T10232 T10230 advmod however,showed
R2593 T10233 T10230 punct ", ",showed
R2594 T10096 T10097 punct (,right
R2595 T10234 T10235 det the,Pygo1
R2596 T10235 T10230 nsubj Pygo1,showed
R2597 T10236 T10235 punct -,Pygo1
R2598 T10097 T10087 parataxis right,Pygo1
R2599 T10237 T10235 punct /,Pygo1
R2600 T10238 T10235 punct -,Pygo1
R2601 T10239 T10235 punct /,Pygo1
R2602 T10240 T10235 appos Pygo2,Pygo1
R2603 T10098 T10099 compound Figure,6O
R2604 T10241 T10240 punct +,Pygo2
R2605 T10242 T10240 punct /,Pygo2
R2606 T10243 T10240 punct -,Pygo2
R2607 T10099 T10097 dep 6O,right
R2608 T10244 T10245 advmod only,50
R2609 T10245 T10246 nummod 50,%
R2610 T10246 T10230 dobj %,showed
R2611 T10100 T10097 punct ", ",right
R2612 T10247 T10246 prep of,%
R2613 T10248 T10249 amod wild,type
R2614 T10249 T10251 compound type,expression
R2615 T10250 T10249 punct -,type
R2616 T10101 T10097 punct ),right
R2617 T10251 T10247 pobj expression,of
R2618 T10252 T10253 compound BAT,gal
R2619 T10253 T10251 compound gal,expression
R2620 T10102 T10054 compound E18.5,kidneys
R2621 T10254 T10253 punct -,gal
R2622 T10255 T10230 punct ", ",showed
R2623 T10256 T10230 advcl suggesting,showed
R2624 T10103 T10104 det a,role
R2625 T10257 T10258 det a,contribution
R2626 T10258 T10256 dobj contribution,suggesting
R2627 T10104 T10051 dobj role,suggested
R2628 T10259 T10258 amod minor,contribution
R2629 T10260 T10258 prep by,contribution
R2630 T10261 T10260 pobj Pygo1,by
R2631 T10262 T10258 prep in,contribution
R2632 T10263 T10264 amod canonical,signaling
R2633 T10264 T10262 pobj signaling,in
R2634 T10265 T10264 compound Wnt,signaling
R2635 T10105 T10104 amod significant,role
R2636 T10266 T10230 punct .,showed
R2637 T10268 T10269 mark Although,decreased
R2638 T10106 T10104 prep for,role
R2639 T10107 T10108 det the,gene
R2640 T10269 T10275 advcl decreased,revealed
R2641 T10270 T10271 compound BAT,gal
R2642 T10108 T10106 pobj gene,for
R2643 T10271 T10273 compound gal,expression
R2644 T10272 T10271 punct -,gal
R2645 T10109 T10108 compound Pygo2,gene
R2646 T10110 T10104 prep in,role
R2647 T10111 T10112 amod canonical,signaling
R2648 T10273 T10269 nsubjpass expression,decreased
R2649 T10112 T10110 pobj signaling,in
R2650 T10274 T10269 auxpass was,decreased
R2651 T10276 T10269 prep in,decreased
R2652 T10277 T10278 det the,kidney
R2653 T10113 T10112 compound Wnt,signaling
R2654 T10278 T10276 pobj kidney,in
R2655 T10279 T10278 nmod E18.5,kidney
R2656 T10280 T10278 nmod Pygo1,kidney
R2657 T10114 T10104 prep in,role
R2658 T10281 T10280 punct -,Pygo1
R2659 T10282 T10280 punct /,Pygo1
R2660 T10283 T10280 punct -,Pygo1
R2661 T10115 T10116 det the,tree
R2662 T10284 T10280 punct /,Pygo1
R2663 T10285 T10280 appos Pygo2,Pygo1
R2664 T10116 T10114 pobj tree,in
R2665 T10286 T10285 punct +,Pygo2
R2666 T10287 T10285 punct /,Pygo2
R2667 T10288 T10285 punct -,Pygo2
R2668 T10117 T10116 amod ureteric,tree
R2669 T10289 T10275 punct ", ",revealed
R2670 T10290 T10291 amod confocal,analysis
R2671 T10291 T10275 nsubj analysis,revealed
R2672 T10118 T10116 cc and,tree
R2673 T10292 T10291 prep of,analysis
R2674 T10293 T10292 pobj kidneys,of
R2675 T10294 T10293 prep with,kidneys
R2676 T10119 T10120 poss its,derivatives
R2677 T10295 T10296 det this,genotype
R2678 T10296 T10294 pobj genotype,with
R2679 T10297 T10298 det no,tips
R2680 T10120 T10116 conj derivatives,tree
R2681 T10298 T10275 dobj tips,revealed
R2682 T10299 T10298 amod dilated,tips
R2683 T10300 T10298 amod ureteric,tips
R2684 T10301 T10298 cc or,tips
R2685 T10302 T10303 amod significant,changes
R2686 T10303 T10298 conj changes,tips
R2687 T10121 T10051 punct .,suggested
R2688 T10304 T10303 prep in,changes
R2689 T10305 T10306 amod ureteric,tip
R2690 T10306 T10307 compound tip,number
R2691 T10123 T10124 prep In,performed
R2692 T10307 T10304 pobj number,in
R2693 T10308 T10307 prep per,number
R2694 T10309 T10308 pobj area,per
R2695 T10310 T10303 prep compared,changes
R2696 T10125 T10123 pobj order,In
R2697 T10311 T10310 prep with,compared
R2698 T10312 T10313 nmod Pygo1,kidneys
R2699 T10313 T10311 pobj kidneys,with
R2700 T10314 T10312 punct -,Pygo1
R2701 T10126 T10127 aux to,validate
R2702 T10315 T10312 punct /,Pygo1
R2703 T10316 T10312 punct -,Pygo1
R2704 T10317 T10312 punct /,Pygo1
R2705 T10127 T10125 acl validate,order
R2706 T10318 T10312 appos Pygo2,Pygo1
R2707 T10319 T10318 punct +,Pygo2
R2708 T10320 T10318 punct /,Pygo2
R2709 T10128 T10127 cc and,validate
R2710 T10321 T10318 punct +,Pygo2
R2711 T10322 T10323 punct (,shown
R2712 T10129 T10127 conj quantify,validate
R2713 T10323 T10275 parataxis shown,revealed
R2714 T10324 T10323 nsubj data,shown
R2715 T10325 T10323 neg not,shown
R2716 T10326 T10323 punct ),shown
R2717 T10130 T10131 det the,changes
R2718 T10327 T10275 punct .,revealed
R2719 T10131 T10129 dobj changes,quantify
R2720 T10329 T10330 advmod Collectively,suggest
R2721 T10331 T10330 punct ", ",suggest
R2722 T10132 T10133 compound BAT,gal
R2723 T10332 T10333 det these,results
R2724 T10333 T10330 nsubj results,suggest
R2725 T10334 T10335 compound BAT,gal
R2726 T10335 T10337 compound gal,reporter
R2727 T10133 T10135 compound gal,reporter
R2728 T10336 T10335 punct -,gal
R2729 T10337 T10333 compound reporter,results
R2730 T10338 T10339 det a,role
R2731 T10134 T10133 punct -,gal
R2732 T10339 T10330 dobj role,suggest
R2733 T10340 T10339 amod significant,role
R2734 T10341 T10339 prep for,role
R2735 T10342 T10343 det the,genes
R2736 T10343 T10341 pobj genes,for
R2737 T10344 T10343 nmod Pygo1,genes
R2738 T10135 T10136 compound reporter,expression
R2739 T10345 T10344 cc and,Pygo1
R2740 T10346 T10344 conj Pygo2,Pygo1
R2741 T10347 T10339 prep in,role
R2742 T10348 T10349 amod canonical,signaling
R2743 T10136 T10131 compound expression,changes
R2744 T10349 T10347 pobj signaling,in
R2745 T10350 T10349 compound Wnt,signaling
R2746 T10351 T10339 prep during,role
R2747 T10137 T10131 prep in,changes
R2748 T10352 T10351 pobj development,during
R2749 T10353 T10352 prep of,development
R2750 T10138 T10139 det the,null
R2751 T10354 T10355 det the,tree
R2752 T10139 T10137 pobj null,in
R2753 T10140 T10139 compound Pygo2,null
R2754 T10141 T10139 cc and,null
R2756 T10142 T10143 compound Pygo1,Pygo2
R2759 T10143 T10145 compound Pygo2,nulls
R2763 T10144 T10143 punct /,Pygo2
R2764 T10145 T10139 conj nulls,null
R2765 T10146 T10124 punct ", ",performed
R2766 T10147 T10124 nsubj we,performed
R2767 T10148 T10149 compound ELISA,measurements
R2768 T10149 T10124 dobj measurements,performed
R2769 T10150 T10149 prep of,measurements
R2770 T10151 T10152 npadvmod transgene,specific
R2771 T10152 T10153 amod specific,levels
R2773 T10153 T10150 pobj levels,of
R2775 T10154 T10155 compound β,galactosidase
R2778 T10155 T10153 compound galactosidase,levels
R2782 T10156 T10155 punct -,galactosidase
R2788 T10157 T10149 prep in,measurements
R2793 T10158 T10159 compound E18.5,kidneys
R2796 T10159 T10157 pobj kidneys,in
R2800 T10160 T10161 punct (,Figure
R2804 T10161 T10124 parataxis Figure,performed
R2808 T10162 T10161 nummod 7,Figure
R2811 T10163 T10161 punct ),Figure
R2816 T10164 T10124 punct .,performed
R2819 T10166 T10167 nsubj Loss,gave
R2825 T10460 T10461 amod ureteric,bud
R2826 T10403 T10401 conj tubules,bodies
R2827 T10404 T10403 punct ", ",tubules
R2828 T10405 T10403 cc and,tubules
R2829 T10406 T10403 conj glomeruli,tubules
R2830 T10461 T10462 compound bud,expression
R2831 T10407 T10363 punct .,showed
R2832 T10409 T10410 nsubjpass This,reported
R2833 T10462 T10457 nsubj expression,rescue
R2834 T10411 T10410 aux has,reported
R2835 T10412 T10410 auxpass been,reported
R2836 T10463 T10462 prep of,expression
R2837 T10413 T10410 advmod previously,reported
R2838 T10414 T10410 punct ", ",reported
R2839 T10415 T10410 cc and,reported
R2840 T10416 T10417 auxpass was,interpreted
R2841 T10417 T10410 conj interpreted,reported
R2842 T10464 T10463 pobj Wnt1,of
R2843 T10418 T10419 aux to,indicate
R2844 T10419 T10417 xcomp indicate,interpreted
R2845 T10420 T10421 det the,absence
R2846 T10465 T10462 punct ", ",expression
R2847 T10421 T10419 dobj absence,indicate
R2848 T10422 T10421 prep of,absence
R2849 T10423 T10424 amod canonical,signaling
R2850 T10424 T10422 pobj signaling,of
R2851 T10466 T10462 acl thought,expression
R2852 T10425 T10424 compound Wnt,signaling
R2853 T10426 T10421 prep in,absence
R2854 T10467 T10468 aux to,act
R2855 T10427 T10428 det the,mesenchyme
R2856 T10428 T10426 pobj mesenchyme,in
R2857 T10429 T10428 amod metanephric,mesenchyme
R2858 T10430 T10431 punct [,21
R2859 T10468 T10466 xcomp act,thought
R2860 T10431 T10419 parataxis 21,indicate
R2861 T10432 T10431 punct ],21
R2862 T10469 T10468 prep through,act
R2863 T10433 T10410 punct .,reported
R2864 T10435 T10436 nsubj Results,argue
R2865 T10470 T10471 amod canonical,signaling
R2866 T10437 T10435 prep from,Results
R2867 T10471 T10469 pobj signaling,through
R2868 T10438 T10439 amod other,studies
R2869 T10439 T10437 pobj studies,from
R2870 T10440 T10436 punct ", ",argue
R2871 T10441 T10436 advmod however,argue
R2872 T10472 T10471 compound Wnt,signaling
R2873 T10442 T10436 punct ", ",argue
R2874 T10443 T10436 prep for,argue
R2875 T10444 T10445 det the,presence
R2876 T10473 T10457 punct ", ",rescue
R2877 T10445 T10443 pobj presence,for
R2878 T10446 T10445 prep of,presence
R2879 T10447 T10448 amod canonical,signaling
R2880 T10474 T10457 aux can,rescue
R2881 T10448 T10446 pobj signaling,of
R2882 T10449 T10448 compound Wnt,signaling
R2883 T10450 T10445 prep in,presence
R2884 T10451 T10452 det the,mesenchyme
R2885 T10475 T10476 compound Wnt9b,mutants
R2886 T10452 T10450 pobj mesenchyme,in
R2887 T10453 T10452 amod metanephric,mesenchyme
R2888 T10454 T10436 punct .,argue
R2889 T10476 T10457 dobj mutants,rescue
R2890 T10456 T10457 prep For,rescue
R2891 T10458 T10456 pobj example,For
R2892 T10459 T10457 punct ", ",rescue
R2893 T10477 T10457 cc and,rescue
R2894 T10478 T10457 conj induce,rescue
R2895 T10479 T10478 dobj nephrogenesis,induce
R2896 T10566 T10567 mark as,expected
R2897 T10480 T10479 prep of,nephrogenesis
R2898 T10567 T10557 advcl expected,undergo
R2899 T10568 T10557 punct ", ",undergo
R2900 T10481 T10482 det the,mesenchyme
R2901 T10569 T10557 cc but,undergo
R2902 T10570 T10557 conj failed,undergo
R2903 T10482 T10480 pobj mesenchyme,of
R2904 T10571 T10572 aux to,show
R2905 T10572 T10570 xcomp show,failed
R2906 T10573 T10574 compound BAT,gal
R2907 T10483 T10482 amod metanephric,mesenchyme
R2908 T10574 T10576 compound gal,expression
R2909 T10575 T10574 punct -,gal
R2910 T10576 T10572 dobj expression,show
R2911 T10484 T10485 punct [,2
R2912 T10485 T10478 parataxis 2,induce
R2913 T10577 T10578 punct (,shown
R2914 T10578 T10572 parataxis shown,show
R2915 T10486 T10485 punct ],2
R2916 T10579 T10578 nsubj data,shown
R2917 T10580 T10578 neg not,shown
R2918 T10581 T10578 punct ),shown
R2919 T10487 T10457 punct .,rescue
R2920 T10582 T10570 punct ", ",failed
R2921 T10583 T10570 advcl suggesting,failed
R2922 T10584 T10585 mark that,is
R2923 T10489 T10490 nsubj This,suggests
R2924 T10585 T10583 ccomp is,suggesting
R2925 T10586 T10587 det this,transgene
R2926 T10587 T10585 nsubj transgene,is
R2927 T10491 T10492 mark that,report
R2928 T10588 T10585 neg not,is
R2929 T10589 T10590 det an,reporter
R2930 T10590 T10585 attr reporter,is
R2931 T10591 T10590 amod accurate,reporter
R2932 T10492 T10490 ccomp report,suggests
R2933 T10592 T10590 prep of,reporter
R2934 T10593 T10594 amod canonical,signaling
R2935 T10594 T10592 pobj signaling,of
R2936 T10493 T10494 det the,transgene
R2937 T10595 T10594 compound Wnt,signaling
R2938 T10596 T10590 prep in,reporter
R2939 T10597 T10598 det the,mesenchyme
R2940 T10494 T10492 nsubj transgene,report
R2941 T10598 T10596 pobj mesenchyme,in
R2942 T10599 T10598 amod metanephric,mesenchyme
R2943 T10600 T10598 prep of,mesenchyme
R2944 T10601 T10602 det the,kidney
R2945 T10602 T10600 pobj kidney,of
R2946 T10603 T10602 amod developing,kidney
R2947 T10495 T10496 compound BAT,gal
R2948 T10604 T10555 punct .,observed
R2949 T10496 T10494 compound gal,transgene
R2950 T10497 T10496 punct -,gal
R2951 T10498 T10492 aux might,report
R2952 T10499 T10492 neg not,report
R2953 T10500 T10492 advmod accurately,report
R2954 T10501 T10502 amod canonical,signaling
R2955 T10502 T10492 dobj signaling,report
R2956 T10503 T10502 compound Wnt,signaling
R2957 T10504 T10492 prep in,report
R2958 T10505 T10506 det the,mesenchyme
R2959 T10506 T10504 pobj mesenchyme,in
R2960 T10507 T10506 amod metanephric,mesenchyme
R2961 T10508 T10490 punct .,suggests
R2962 T10510 T10511 aux To,address
R2963 T10511 T10512 advcl address,incubated
R2964 T10513 T10514 det this,question
R2965 T10514 T10511 dobj question,address
R2966 T10515 T10512 punct ", ",incubated
R2967 T10516 T10512 nsubj we,incubated
R2968 T10517 T10518 nmod E11.5,mesenchyme
R2969 T10518 T10512 dobj mesenchyme,incubated
R2970 T10519 T10518 amod metanephric,mesenchyme
R2971 T10520 T10512 prep in,incubated
R2972 T10521 T10522 compound lithium,chloride
R2973 T10522 T10520 pobj chloride,in
R2974 T10523 T10522 punct (,chloride
R2975 T10524 T10522 appos LiCl,chloride
R2976 T10525 T10522 punct ),chloride
R2977 T10526 T10522 punct ", ",chloride
R2978 T10527 T10528 dep which,activates
R2979 T10528 T10522 relcl activates,chloride
R2980 T10529 T10530 amod canonical,signaling
R2981 T10530 T10528 dobj signaling,activates
R2982 T10531 T10530 compound Wnt,signaling
R2983 T10532 T10528 prep through,activates
R2984 T10533 T10532 pobj inhibition,through
R2985 T10534 T10533 prep of,inhibition
R2986 T10535 T10534 pobj GSK3,of
R2987 T10536 T10528 punct ", ",activates
R2988 T10537 T10528 cc and,activates
R2989 T10538 T10539 advmod also,functions
R2990 T10539 T10528 conj functions,activates
R2991 T10540 T10539 prep as,functions
R2992 T10541 T10542 det an,inducer
R2993 T10542 T10540 pobj inducer,as
R2994 T10543 T10542 prep of,inducer
R2995 T10544 T10543 pobj nephrogenesis,of
R2996 T10545 T10542 prep in,inducer
R2997 T10546 T10547 compound kidney,organ
R2998 T10547 T10548 compound organ,culture
R2999 T10548 T10545 pobj culture,in
R3000 T10549 T10550 punct [,22
R3001 T10550 T10539 parataxis 22,functions
R3002 T10551 T10550 punct ],22
R3003 T10552 T10512 punct .,incubated
R3004 T10554 T10555 nsubj We,observed
R3005 T10556 T10557 mark that,undergo
R3006 T10557 T10555 ccomp undergo,observed
R3007 T10558 T10559 npadvmod LiCl,treated
R3008 T10559 T10561 amod treated,mesenchyme
R3009 T10560 T10559 punct -,treated
R3010 T10561 T10557 nsubj mesenchyme,undergo
R3011 T10562 T10561 amod metanephric,mesenchyme
R3012 T10563 T10557 aux did,undergo
R3013 T10564 T10557 dobj nephrogenesis,undergo
R3014 T10565 T10557 punct ", ",undergo
R3017 T12039 T12040 compound Microarray,analysis
R3018 T12041 T12040 prep of,analysis
R3019 T12042 T12043 compound Pygo1,Pygo2
R3020 T12043 T12045 npadvmod Pygo2,null
R3021 T12044 T12043 punct /,Pygo2
R3022 T12045 T12046 amod null,kidneys
R3023 T12046 T12041 pobj kidneys,of
R3024 T12048 T12049 aux To,examine
R3025 T12049 T12051 advcl examine,used
R3026 T12050 T12049 advmod further,examine
R3027 T12052 T12053 amod possible,disturbance
R3028 T12053 T12049 dobj disturbance,examine
R3029 T12054 T12053 prep of,disturbance
R3030 T12055 T12056 compound gene,expression
R3031 T12056 T12054 pobj expression,of
R3032 T12057 T12049 prep in,examine
R3033 T12058 T12059 det the,kidneys
R3034 T12059 T12057 pobj kidneys,in
R3035 T12060 T12061 compound Pygo1,Pygo2
R3036 T12061 T12059 compound Pygo2,kidneys
R3037 T12062 T12061 punct /,Pygo2
R3038 T12063 T12059 compound mutant,kidneys
R3039 T12064 T12051 punct ", ",used
R3040 T12065 T12051 nsubj we,used
R3041 T12066 T12051 dobj microarrays,used
R3042 T12067 T12068 aux to,perform
R3043 T12068 T12051 advcl perform,used
R3044 T12069 T12070 det a,analysis
R3045 T12070 T12068 dobj analysis,perform
R3046 T12071 T12070 amod global,analysis
R3047 T12072 T12070 prep of,analysis
R3048 T12073 T12074 compound gene,expression
R3049 T12074 T12075 compound expression,changes
R3050 T12075 T12072 pobj changes,of
R3051 T12076 T12051 punct .,used
R3052 T12078 T12079 mark Whereas,monitors
R3053 T12079 T12086 advcl monitors,used
R3054 T12080 T12081 det the,reporter
R3055 T12081 T12079 nsubj reporter,monitors
R3056 T12082 T12083 compound BAT,gal
R3057 T12083 T12085 compound gal,transgene
R3058 T12084 T12083 punct -,gal
R3059 T12085 T12081 compound transgene,reporter
R3060 T12087 T12088 det the,response
R3061 T12088 T12079 dobj response,monitors
R3062 T12089 T12088 prep of,response
R3063 T12090 T12091 nummod one,promoter
R3064 T12091 T12089 pobj promoter,of
R3065 T12092 T12088 prep to,response
R3066 T12093 T12094 compound Wnt,signaling
R3067 T12094 T12092 pobj signaling,to
R3068 T12095 T12086 punct ", ",used
R3069 T12096 T12086 nsubjpass microarrays,used
R3070 T12097 T12086 aux can,used
R3071 T12098 T12086 auxpass be,used
R3072 T12099 T12100 aux to,follow
R3073 T12100 T12086 advcl follow,used
R3074 T12101 T12102 compound expression,changes
R3075 T12102 T12100 dobj changes,follow
R3076 T12103 T12102 prep of,changes
R3077 T12104 T12105 det all,genes
R3078 T12105 T12103 pobj genes,of
R3079 T12106 T12105 punct ", ",genes
R3080 T12107 T12105 prep including,genes
R3081 T12108 T12109 det all,targets
R3082 T12109 T12107 pobj targets,including
R3083 T12110 T12109 amod known,targets
R3084 T12111 T12109 compound Wnt,targets
R3085 T12112 T12086 punct .,used
R3086 T12114 T12115 nmod E18.5,kidneys
R3087 T12115 T12129 nsubjpass kidneys,examined
R3088 T12116 T12117 amod wild,type
R3089 T12117 T12115 nmod type,kidneys
R3090 T12118 T12117 punct -,type
R3091 T12119 T12117 cc and,type
R3092 T12120 T12117 conj Pygo1,type
R3093 T12121 T12120 punct -,Pygo1
R3094 T12122 T12120 punct /,Pygo1
R3095 T12123 T12120 punct -,Pygo1
R3096 T12124 T12120 punct /,Pygo1
R3097 T12125 T12120 appos Pygo2,Pygo1
R3098 T12126 T12125 punct -,Pygo2
R3099 T12127 T12125 punct /,Pygo2
R3100 T12128 T12125 punct -,Pygo2
R3101 T12130 T12129 auxpass were,examined
R3102 T12131 T12129 prep in,examined
R3103 T12132 T12133 amod biological,triplicate
R3104 T12133 T12131 pobj triplicate,in
R3105 T12134 T12129 punct .,examined
R3106 T12136 T12137 prep In,identified
R3107 T12138 T12136 amod total,In
R3108 T12139 T12137 punct ", ",identified
R3109 T12140 T12141 nummod 45,genes
R3110 T12141 T12137 nsubjpass genes,identified
R3111 T12142 T12137 auxpass were,identified
R3112 T12143 T12137 prep as,identified
R3113 T12144 T12145 advmod significantly,changed
R3114 T12145 T12143 amod changed,as
R3115 T12146 T12137 punct ", ",identified
R3116 T12147 T12137 advcl using,identified
R3117 T12148 T12149 det a,screen
R3118 T12149 T12147 dobj screen,using
R3119 T12150 T12151 advmod relatively,low
R3120 T12151 T12149 amod low,screen
R3121 T12152 T12149 compound stringency,screen
R3122 T12153 T12149 prep of,screen
R3123 T12154 T12155 det the,data
R3124 T12155 T12153 pobj data,of
R3125 T12156 T12137 punct ", ",identified
R3126 T12157 T12137 prep with,identified
R3127 T12158 T12159 det a,cutoff
R3128 T12159 T12157 pobj cutoff,with
R3129 T12160 T12161 compound p,value
R3130 T12161 T12159 compound value,cutoff
R3131 T12162 T12161 punct -,value
R3132 T12163 T12159 prep of,cutoff
R3133 T12164 T12165 punct <,0.05
R3134 T12165 T12163 pobj 0.05,of
R3135 T12166 T12159 punct ", ",cutoff
R3136 T12167 T12159 cc and,cutoff
R3137 T12168 T12169 compound fold,change
R3138 T12169 T12159 conj change,cutoff
R3139 T12170 T12171 punct >,2
R3140 T12171 T12169 appos 2,change
R3141 T12172 T12173 punct (,Table
R3142 T12173 T12137 parataxis Table,identified
R3143 T12174 T12173 nummod 3,Table
R3144 T12175 T12173 punct ),Table
R3145 T12176 T12137 punct .,identified
R3146 T12178 T12179 advmod Notably,identified
R3147 T12180 T12179 punct ", ",identified
R3148 T12181 T12182 preconj both,Pygo1
R3149 T12182 T12179 nsubjpass Pygo1,identified
R3150 T12183 T12182 cc and,Pygo1
R3151 T12184 T12182 conj Pygo2,Pygo1
R3152 T12185 T12179 auxpass were,identified
R3153 T12186 T12179 prep as,identified
R3154 T12187 T12186 amod downregulated,as
R3155 T12188 T12189 punct (,respectively
R3156 T12189 T12187 parataxis respectively,downregulated
R3157 T12190 T12191 punct -,5.3-fold
R3158 T12191 T12189 advmod 5.3-fold,respectively
R3159 T12192 T12191 cc and,5.3-fold
R3160 T12193 T12194 punct -,3.9-fold
R3161 T12194 T12191 conj 3.9-fold,5.3-fold
R3162 T12195 T12189 punct ", ",respectively
R3163 T12196 T12189 punct ),respectively
R3164 T12197 T12179 prep in,identified
R3165 T12198 T12199 det the,kidneys
R3166 T12199 T12197 pobj kidneys,in
R3167 T12200 T12199 compound mutant,kidneys
R3168 T12201 T12179 punct .,identified
R3169 T12203 T12204 amod Other,genes
R3170 T12204 T12205 nsubj genes,included
R3171 T12206 T12204 prep with,genes
R3172 T12207 T12208 amod significant,decreases
R3173 T12208 T12206 pobj decreases,with
R3174 T12209 T12208 prep in,decreases
R3175 T12210 T12211 compound mutant,kidneys
R3176 T12211 T12209 pobj kidneys,in
R3177 T12212 T12205 dobj Cxcl13,included
R3178 T12213 T12214 punct (,2.3-fold
R3179 T12214 T12212 parataxis 2.3-fold,Cxcl13
R3180 T12215 T12214 punct -,2.3-fold
R3181 T12216 T12214 punct ),2.3-fold
R3182 T12217 T12212 punct ", ",Cxcl13
R3183 T12218 T12212 conj Slc5a2,Cxcl13
R3184 T12219 T12220 punct (,2.8-fold
R3185 T12220 T12218 parataxis 2.8-fold,Slc5a2
R3186 T12221 T12220 punct -,2.8-fold
R3187 T12222 T12220 punct ),2.8-fold
R3188 T12223 T12218 punct ", ",Slc5a2
R3189 T12224 T12218 cc and,Slc5a2
R3190 T12225 T12218 conj Slco1a4,Slc5a2
R3191 T12226 T12227 punct (,2.1-fold
R3192 T12227 T12225 parataxis 2.1-fold,Slco1a4
R3193 T12228 T12227 punct -,2.1-fold
R3194 T12229 T12227 punct ),2.1-fold
R3195 T12230 T12205 punct .,included
R3196 T12232 T12233 nsubjpass Slc5a2,expressed
R3197 T12234 T12233 auxpass is,expressed
R3198 T12235 T12233 prep in,expressed
R3199 T12236 T12237 det the,tubules
R3200 T12237 T12235 pobj tubules,in
R3201 T12238 T12237 amod proximal,tubules
R3202 T12239 T12237 prep of,tubules
R3203 T12240 T12241 det the,nephron
R3204 T12241 T12239 pobj nephron,of
R3205 T12242 T12241 amod adult,nephron
R3206 T12243 T12233 cc and,expressed
R3207 T12244 T12245 aux has,implicated
R3208 T12245 T12233 conj implicated,expressed
R3209 T12246 T12245 auxpass been,implicated
R3210 T12247 T12245 prep in,implicated
R3211 T12248 T12249 amod autosomal,recessive
R3212 T12249 T12250 amod recessive,glucosuria
R3213 T12250 T12247 pobj glucosuria,in
R3214 T12251 T12250 amod renal,glucosuria
R3215 T12252 T12250 punct ", ",glucosuria
R3216 T12253 T12250 acl characterized,glucosuria
R3217 T12254 T12253 agent by,characterized
R3218 T12255 T12254 pobj loss,by
R3219 T12256 T12255 prep of,loss
R3220 T12257 T12258 compound glucose,uptake
R3221 T12258 T12256 pobj uptake,of
R3222 T12259 T12258 prep by,uptake
R3223 T12260 T12261 det the,nephron
R3224 T12261 T12259 pobj nephron,by
R3225 T12262 T12263 punct [,23
R3226 T12263 T12253 parataxis 23,characterized
R3227 T12264 T12263 punct ],23
R3228 T12265 T12233 punct .,expressed
R3229 T12267 T12268 det The,transporter
R3230 T12268 T12271 nsubjpass transporter,expressed
R3231 T12269 T12268 amod organic,transporter
R3232 T12270 T12268 compound anion,transporter
R3233 T12272 T12268 punct ", ",transporter
R3234 T12273 T12268 appos Slco1a4,transporter
R3235 T12274 T12271 punct ", ",expressed
R3236 T12275 T12271 auxpass is,expressed
R3237 T12276 T12271 advmod also,expressed
R3266 T12307 T12308 amod subsequent,function
R3267 T12308 T12305 conj function,maturation
R3268 T12309 T12292 punct .,suggest
R3269 T12312 T12313 amod Noteworthy,genes
R3270 T12313 T12314 nsubj genes,included
R3271 T12315 T12313 acl upregulated,genes
R3272 T12316 T12315 prep in,upregulated
R3273 T12317 T12318 det the,kidney
R3274 T12318 T12316 pobj kidney,in
R3275 T12319 T12320 compound Pygo1,Pygo2
R3276 T12320 T12322 npadvmod Pygo2,null
R3277 T12321 T12320 punct /,Pygo2
R3278 T12322 T12318 amod null,kidney
R3279 T12323 T12314 dobj Klk5,included
R3280 T12324 T12325 punct (,2.8-fold
R3281 T12325 T12323 parataxis 2.8-fold,Klk5
R3282 T12326 T12325 punct ),2.8-fold
R3283 T12327 T12323 punct ", ",Klk5
R3284 T12328 T12323 conj Klk6,Klk5
R3285 T12329 T12330 punct (,2.7-fold
R3286 T12330 T12328 parataxis 2.7-fold,Klk6
R3287 T12331 T12330 punct ),2.7-fold
R3288 T12332 T12328 punct ", ",Klk6
R3289 T12333 T12328 conj Ren2,Klk6
R3290 T12334 T12335 punct (,2.2-fold
R3291 T12335 T12333 parataxis 2.2-fold,Ren2
R3292 T12336 T12335 punct ),2.2-fold
R3293 T12337 T12333 punct ", ",Ren2
R3294 T12338 T12333 cc and,Ren2
R3295 T12339 T12333 conj Timeless,Ren2
R3296 T12340 T12341 punct (,2.4-fold
R3297 T12341 T12339 parataxis 2.4-fold,Timeless
R3298 T12342 T12341 punct ),2.4-fold
R3299 T12343 T12314 punct .,included
R3300 T12345 T12346 nsubj Klk5,are
R3301 T12347 T12345 cc and,Klk5
R3302 T12348 T12345 conj Klk6,Klk5
R3303 T12349 T12346 attr members,are
R3304 T12350 T12349 prep of,members
R3305 T12351 T12352 det the,family
R3306 T12352 T12350 pobj family,of
R3307 T12353 T12352 compound kallikrein,family
R3308 T12354 T12352 prep of,family
R3309 T12355 T12356 npadvmod trypsin,like
R3310 T12356 T12358 amod like,proteases
R3311 T12357 T12356 punct -,like
R3312 T12358 T12354 pobj proteases,of
R3313 T12359 T12358 compound serine,proteases
R3314 T12360 T12346 punct .,are
R3315 T12362 T12363 nsubj Kallikreins,have
R3316 T12364 T12365 amod diverse,functions
R3317 T12365 T12363 dobj functions,have
R3318 T12366 T12363 prep in,have
R3319 T12367 T12366 pobj cancer,in
R3320 T12368 T12367 punct ", ",cancer
R3321 T12369 T12370 compound tissue,remodeling
R3322 T12370 T12367 conj remodeling,cancer
R3323 T12371 T12370 punct ", ",remodeling
R3324 T12372 T12370 cc and,remodeling
R3325 T12373 T12370 conj regulation,remodeling
R3326 T12374 T12373 prep of,regulation
R3327 T12375 T12376 compound blood,pressure
R3328 T12376 T12374 pobj pressure,of
R3329 T12377 T12378 punct [,25
R3330 T12378 T12363 parataxis 25,have
R3331 T12379 T12378 punct ],25
R3332 T12380 T12363 punct .,have
R3333 T12382 T12383 nsubj Ren2,activates
R3334 T12384 T12382 punct ", ",Ren2
R3335 T12385 T12386 det a,homolog
R3336 T12386 T12382 appos homolog,Ren2
R3337 T12387 T12386 prep of,homolog
R3338 T12388 T12389 det the,endopeptidase
R3339 T12389 T12387 pobj endopeptidase,of
R3340 T12390 T12389 appos Renin,endopeptidase
R3341 T12391 T12390 nummod 1,Renin
R3342 T12392 T12383 punct ", ",activates
R3343 T12393 T12394 det the,system
R3344 T12394 T12383 dobj system,activates
R3345 T12395 T12396 compound renin,angiotensin
R3346 T12396 T12394 compound angiotensin,system
R3347 T12397 T12396 punct -,angiotensin
R3348 T12398 T12383 punct ", ",activates
R3349 T12399 T12383 advcl increasing,activates
R3350 T12400 T12401 compound blood,pressure
R3351 T12401 T12399 dobj pressure,increasing
R3352 T12402 T12403 punct [,26
R3353 T12403 T12383 parataxis 26,activates
R3354 T12404 T12403 punct ],26
R3355 T12405 T12383 punct .,activates
R3356 T12407 T12408 nsubj Disruption,results
R3357 T12409 T12407 prep of,Disruption
R3358 T12410 T12411 det the,system
R3359 T12411 T12409 pobj system,of
R3360 T12412 T12413 compound renin,angiotensin
R3361 T12413 T12411 compound angiotensin,system
R3362 T12414 T12413 punct -,angiotensin
R3363 T12415 T12407 prep during,Disruption
R3364 T12416 T12415 pobj development,during
R3365 T12417 T12408 prep in,results
R3366 T12418 T12419 amod congenital,abnormalities
R3367 T12419 T12417 pobj abnormalities,in
R3368 T12420 T12419 prep of,abnormalities
R3369 T12421 T12422 det the,ureter
R3370 T12422 T12420 pobj ureter,of
R3371 T12423 T12422 cc and,ureter
R3372 T12424 T12425 compound collecting,duct
R3373 T12425 T12427 compound duct,system
R3374 T12426 T12425 punct -,duct
R3375 T12427 T12422 conj system,ureter
R3376 T12428 T12429 punct [,27
R3377 T12429 T12408 parataxis 27,results
R3378 T12430 T12429 punct ],27
R3379 T12431 T12408 punct .,results
R3380 T12433 T12434 nsubjpass Timeless,shown
R3381 T12435 T12433 punct ", ",Timeless
R3382 T12436 T12437 det a,factor
R3383 T12437 T12433 appos factor,Timeless
R3384 T12438 T12437 compound transcription,factor
R3385 T12439 T12437 acl involved,factor
R3386 T12440 T12439 prep in,involved
R3387 T12441 T12442 det the,regulation
R3388 T12442 T12440 pobj regulation,in
R3389 T12443 T12442 prep of,regulation
R3390 T12444 T12445 amod circadian,rhythms
R3391 T12445 T12443 pobj rhythms,of
R3392 T12446 T12439 punct ", ",involved
R3393 T12447 T12439 cc and,involved
R3394 T12448 T12439 conj expressed,involved
R3395 T12449 T12448 prep in,expressed
R3396 T12450 T12451 det the,tips
R3397 T12451 T12449 pobj tips,in
R3398 T12452 T12451 amod branching,tips
R3399 T12453 T12451 amod ureteric,tips
R3400 T12454 T12434 punct ", ",shown
R3401 T12455 T12434 aux has,shown
R3402 T12456 T12434 advmod also,shown
R3403 T12457 T12434 auxpass been,shown
R3404 T12458 T12459 aux to,regulate
R3405 T12459 T12434 xcomp regulate,shown
R3406 T12460 T12461 amod ureteric,morphogenesis
R3407 T12461 T12459 dobj morphogenesis,regulate
R3408 T12462 T12461 compound branching,morphogenesis
R3409 T12463 T12464 punct [,28
R3410 T12464 T12434 parataxis 28,shown
R3411 T12465 T12464 punct ],28
R3412 T12466 T12434 punct .,shown
R3413 T12468 T12469 nsubj We,were
R3414 T12470 T12469 acomp interested,were
R3415 T12471 T12470 prep in,interested
R3416 T12472 T12473 det the,expression
R3417 T12473 T12471 pobj expression,in
R3418 T12474 T12473 amod possible,expression
R3419 T12475 T12473 amod altered,expression
R3420 T12476 T12473 prep of,expression
R3421 T12477 T12478 advmod previously,known
R3422 T12478 T12479 amod known,targets
R3423 T12479 T12476 pobj targets,of
R3424 T12480 T12479 compound Wnt,targets
R3425 T12481 T12469 prep in,were
R3426 T12482 T12483 det the,kidneys
R3427 T12483 T12481 pobj kidneys,in
R3428 T12484 T12485 nmod Pygo1,mutant
R3429 T12485 T12483 compound mutant,kidneys
R3430 T12486 T12484 punct -,Pygo1
R3431 T12487 T12484 punct /,Pygo1
R3432 T12488 T12484 punct -,Pygo1
R3433 T12489 T12484 punct /,Pygo1
R3434 T12490 T12484 appos Pygo2,Pygo1
R3435 T12491 T12490 punct -,Pygo2
R3436 T12492 T12490 punct /,Pygo2
R3437 T12493 T12490 punct -,Pygo2
R3438 T12494 T12469 punct .,were
R3439 T12496 T12497 det A,list
R3440 T12497 T12498 nsubjpass list,compiled
R3441 T12499 T12497 prep of,list
R3442 T12500 T12501 amod known,targets
R3443 T12501 T12499 pobj targets,of
R3444 T12502 T12501 compound Wnt,targets
R3445 T12503 T12498 auxpass was,compiled
R3446 T12504 T12498 prep from,compiled
R3447 T12505 T12498 punct .,compiled
R3448 T12507 T12508 preconj Both,Pygo1
R3449 T12508 T12509 nmod Pygo1,sets
R3450 T12509 T12513 nsubjpass sets,included
R3451 T12510 T12508 cc and,Pygo1
R3452 T12511 T12508 conj Pygo2,Pygo1
R3453 T12512 T12509 compound probe,sets
R3454 T12514 T12513 auxpass were,included
R3455 T12515 T12513 prep as,included
R3456 T12516 T12515 pobj references,as
R3457 T12517 T12518 aux to,illustrate
R3458 T12518 T12513 advcl illustrate,included
R3459 T12519 T12520 amod significant,regulation
R3460 T12520 T12518 dobj regulation,illustrate
R3461 T12521 T12520 amod down,regulation
R3462 T12522 T12513 punct .,included
R3463 T12524 T12525 advmod Remarkably,showed
R3464 T12526 T12525 punct ", ",showed
R3465 T12527 T12528 det the,genes
R3466 T12528 T12525 nsubj genes,showed
R3467 T12529 T12528 amod known,genes
R3468 T12530 T12531 compound Wnt,target
R3469 T12531 T12528 compound target,genes
R3470 T12532 T12533 advmod very,few
R3471 T12533 T12534 amod few,differences
R3472 T12534 T12525 dobj differences,showed
R3473 T12535 T12534 prep in,differences
R3474 T12536 T12535 pobj expression,in
R3475 T12537 T12534 prep between,differences
R3476 T12538 T12539 amod wild,type
R3477 T12539 T12541 nmod type,kidneys
R3478 T12540 T12539 punct -,type
R3479 T12541 T12537 pobj kidneys,between
R3480 T12542 T12539 cc and,type
R3481 T12543 T12539 conj mutant,type
R3482 T12544 T12545 punct (,Figure
R3483 T12545 T12525 parataxis Figure,showed
R3484 T12546 T12545 nummod 8,Figure
R3485 T12547 T12545 punct ),Figure
R3486 T12548 T12525 punct .,showed
R3487 T12550 T12551 advmod Only,expression
R3488 T12551 T12553 nsubjpass expression,changed
R3489 T12552 T12551 det the,expression
R3490 T12554 T12551 prep of,expression
R3491 T12555 T12556 npadvmod Ccnd1,encoding
R3492 T12556 T12557 amod encoding,D1
R3493 T12557 T12554 pobj D1,of
R3494 T12558 T12557 compound cyclin,D1
R3495 T12559 T12560 punct [,29
R3496 T12560 T12557 parataxis 29,D1
R3497 T12561 T12560 punct ],29
R3498 T12562 T12557 punct ", ",D1
R3499 T12563 T12557 cc and,D1
R3500 T12564 T12557 conj Wisp1,D1
R3501 T12565 T12566 punct [,30
R3502 T12566 T12564 parataxis 30,Wisp1
R3503 T12567 T12566 punct ],30
R3504 T12568 T12553 auxpass were,changed
R3505 T12569 T12553 advmod significantly,changed
R3506 T12570 T12553 punct ", ",changed
R3507 T12571 T12553 prep with,changed
R3508 T12572 T12573 compound expression,level
R3509 T12573 T12574 compound level,changes
R3510 T12574 T12571 pobj changes,with
R3511 T12575 T12574 prep of,changes
R3512 T12576 T12577 punct <,1.5-fold
R3513 T12577 T12575 pobj 1.5-fold,of
R3514 T12578 T12574 prep in,changes
R3515 T12579 T12580 compound Pygo1,Pygo2
R3516 T12580 T12582 npadvmod Pygo2,null
R3517 T12581 T12580 punct /,Pygo2
R3518 T12582 T12583 amod null,kidneys
R3519 T12583 T12578 pobj kidneys,in
R3520 T12584 T12553 punct .,changed
R3521 T12586 T12587 det These,results
R3522 T12587 T12588 nsubj results,indicate
R3523 T12589 T12590 det an,absence
R3524 T12590 T12588 dobj absence,indicate
R3525 T12591 T12590 prep of,absence
R3526 T12592 T12593 amod dramatic,changes
R3527 T12593 T12591 pobj changes,of
R3528 T12594 T12593 prep in,changes
R3529 T12595 T12594 pobj expression,in
R3530 T12596 T12595 prep of,expression
R3531 T12597 T12598 advmod previously,known
R3532 T12598 T12599 amod known,genes
R3534 T12600 T12601 compound Wnt,signaling
R3573 T12643 T12644 det a,change
R3574 T12644 T12639 dobj change,observe
R3575 T12645 T12644 amod significant,change
R3576 T12646 T12644 compound fold,change
R3577 T12647 T12644 prep in,change
R3578 T12648 T12649 det the,direction
R3579 T12649 T12647 pobj direction,in
R3580 T12650 T12649 amod same,direction
R3581 T12651 T12649 acl predicted,direction
R3582 T12652 T12651 agent by,predicted
R3583 T12653 T12654 det the,results
R3584 T12654 T12652 pobj results,by
R3585 T12655 T12654 compound microarray,results
R3586 T12656 T12657 punct (,Table
R3587 T12657 T12639 parataxis Table,observe
R3588 T12658 T12657 nummod 4,Table
R3589 T12659 T12657 punct ),Table
R3590 T12660 T12639 punct .,observe
R3591 T12662 T12663 nsubj It,is
R3592 T12664 T12665 neg not,surprising
R3593 T12665 T12663 acomp surprising,is
R3594 T12666 T12667 mark that,validated
R3595 T12667 T12663 ccomp validated,is
R3596 T12668 T12667 nsubjpass two,validated
R3597 T12669 T12668 prep of,two
R3598 T12670 T12671 det the,genes
R3599 T12671 T12669 pobj genes,of
R3600 T12672 T12671 nummod nine,genes
R3601 T12673 T12667 aux could,validated
R3602 T12674 T12667 neg not,validated
R3603 T12675 T12667 auxpass be,validated
R3604 T12676 T12663 punct ", ",is
R3605 T12677 T12663 advcl considering,is
R3606 T12678 T12679 det the,stringency
R3607 T12679 T12677 dobj stringency,considering
R3608 T12680 T12681 advmod relatively,low
R3609 T12681 T12679 amod low,stringency
R3610 T12682 T12679 acl used,stringency
R3611 T12683 T12682 prep in,used
R3612 T12684 T12683 pcomp screening,in
R3613 T12685 T12686 det the,data
R3614 T12686 T12684 dobj data,screening
R3615 T12687 T12686 compound microarray,data
R3616 T12688 T12663 punct .,is
R3623 T15289 T15290 prep In,is
R3624 T15291 T15289 pobj Drosophila,In
R3625 T15292 T15290 punct ", ",is
R3626 T15293 T15294 det the,gene
R3627 T15294 T15290 nsubj gene,is
R3628 T15295 T15294 compound Pygopus,gene
R3629 T15296 T15297 det a,mediator
R3630 T15297 T15290 attr mediator,is
R3631 T15298 T15297 amod key,mediator
R3632 T15299 T15297 prep of,mediator
R3633 T15300 T15301 amod canonical,signaling
R3634 T15301 T15299 pobj signaling,of
R3635 T15302 T15301 compound Wnt,signaling
R3636 T15303 T15290 punct .,is
R3637 T15305 T15306 prep In,performed
R3638 T15307 T15308 nummod one,study
R3639 T15308 T15305 pobj study,In
R3640 T15309 T15306 punct ", ",performed
R3641 T15310 T15311 nummod 12,measures
R3642 T15311 T15306 nsubjpass measures,performed
R3643 T15312 T15311 amod distinct,measures
R3644 T15313 T15311 prep of,measures
R3645 T15314 T15315 compound Wnt,signaling
R3646 T15315 T15313 pobj signaling,of
R3647 T15316 T15315 prep in,signaling
R3648 T15317 T15318 compound Pygo,mutants
R3649 T15318 T15316 pobj mutants,in
R3650 T15319 T15306 auxpass were,performed
R3651 T15320 T15306 punct ", ",performed
R3652 T15321 T15306 prep including,performed
R3653 T15322 T15321 pobj analysis,including
R3654 T15323 T15322 prep of,analysis
R3655 T15324 T15325 npadvmod leg,imaginal
R3656 T15325 T15331 amod imaginal,discs
R3657 T15326 T15324 punct ", ",leg
R3658 T15327 T15324 conj wing,leg
R3659 T15328 T15327 punct ", ",wing
R3660 T15329 T15327 cc and,wing
R3661 T15330 T15327 conj eye,wing
R3662 T15331 T15323 pobj discs,of
R3663 T15332 T15306 punct .,performed
R3664 T15334 T15335 prep In,was
R3665 T15336 T15337 nummod 2,cases
R3666 T15337 T15334 pobj cases,In
R3667 T15338 T15335 expl there,was
R3668 T15339 T15340 det a,reduction
R3669 T15340 T15335 attr reduction,was
R3670 T15341 T15340 amod significant,reduction
R3671 T15342 T15340 prep of,reduction
R3672 T15343 T15344 compound Wnt,signaling
R3673 T15344 T15342 pobj signaling,of
R3674 T15345 T15335 cc and,was
R3675 T15346 T15347 prep in,block
R3676 T15347 T15335 conj block,was
R3677 T15348 T15349 nummod 10,cases
R3678 T15349 T15346 pobj cases,in
R3679 T15350 T15347 det a,block
R3680 T15351 T15347 amod complete,block
R3681 T15352 T15353 punct [,10
R3682 T15353 T15347 parataxis 10,block
R3683 T15354 T15353 punct ],10
R3684 T15355 T15347 punct .,block
R3685 T15357 T15358 det A,study
R3686 T15358 T15360 nsubj study,examined
R3687 T15359 T15358 amod second,study
R3688 T15361 T15358 prep in,study
R3689 T15362 T15361 pobj Drosophila,in
R3690 T15363 T15364 det the,effects
R3691 T15364 T15360 dobj effects,examined
R3692 T15365 T15364 prep of,effects
R3693 T15366 T15367 compound Pygo,mutation
R3694 T15367 T15365 pobj mutation,of
R3695 T15368 T15364 prep on,effects
R3696 T15369 T15370 compound cuticle,patterning
R3697 T15370 T15368 pobj patterning,on
R3698 T15371 T15370 punct ", ",patterning
R3699 T15372 T15373 compound midgut,constriction
R3700 T15373 T15370 conj constriction,patterning
R3701 T15374 T15373 punct ", ",constriction
R3702 T15375 T15376 amod central,system
R3703 T15376 T15373 conj system,constriction
R3704 T15377 T15376 amod nervous,system
R3705 T15378 T15376 punct ", ",system
R3706 T15379 T15376 cc and,system
R3707 T15380 T15381 amod cardiac,development
R3708 T15381 T15376 conj development,system
R3709 T15382 T15360 punct ", ",examined
R3710 T15383 T15360 cc and,examined
R3711 T15384 T15360 conj concluded,examined
R3712 T15385 T15386 mark that,is
R3713 T15386 T15384 ccomp is,concluded
R3714 T15387 T15386 punct """",is
R3715 T15388 T15386 nsubj Pygo,is
R3716 T15389 T15390 det an,component
R3717 T15390 T15386 attr component,is
R3718 T15391 T15390 amod essential,component
R3719 T15392 T15390 prep in,component
R3720 T15393 T15394 det the,pathway
R3721 T15394 T15392 pobj pathway,in
R3722 T15395 T15394 compound Wg,pathway
R3723 T15396 T15397 compound signal,transduction
R3724 T15397 T15394 compound transduction,pathway
R3725 T15398 T15384 punct """",concluded
R3726 T15399 T15384 punct .,concluded
R3727 T15400 T15401 punct [,8
R3728 T15401 T15384 parataxis 8,concluded
R3729 T15402 T15401 punct ],8
R3730 T15403 T15360 punct .,examined
R3731 T15405 T15406 prep Given,were
R3732 T15407 T15408 det these,results
R3733 T15408 T15405 pobj results,Given
R3734 T15409 T15408 prep in,results
R3735 T15410 T15409 pobj Drosophila,in
R3736 T15411 T15406 punct ", ",were
R3737 T15412 T15413 det the,phenotypes
R3738 T15413 T15406 nsubj phenotypes,were
R3739 T15414 T15415 advmod relatively,mild
R3740 T15415 T15413 amod mild,phenotypes
R3741 T15416 T15413 prep of,phenotypes
R3742 T15417 T15416 pobj mice,of
R3743 T15418 T15417 prep with,mice
R3744 T15419 T15420 amod targeted,Pygo1
R3745 T15420 T15421 nmod Pygo1,mutations
R3746 T15421 T15418 pobj mutations,with
R3747 T15422 T15420 punct ", ",Pygo1
R3748 T15423 T15420 conj Pygo2,Pygo1
R3749 T15424 T15423 punct ", ",Pygo2
R3750 T15425 T15423 cc or,Pygo2
R3751 T15426 T15427 amod double,Pygo2
R3752 T15427 T15423 conj Pygo2,Pygo2
R3753 T15428 T15427 compound Pygo1,Pygo2
R3754 T15429 T15427 punct /,Pygo2
R3755 T15430 T15406 acomp striking,were
R3756 T15431 T15406 punct .,were
R3757 T15433 T15434 compound Pygo2,mutants
R3758 T15434 T15435 nsubj mutants,developed
R3759 T15436 T15435 prep to,developed
R3760 T15437 T15436 pobj birth,to
R3761 T15438 T15435 cc and,developed
R3762 T15439 T15435 conj showed,developed
R3763 T15440 T15441 amod limited,abnormalities
R3764 T15441 T15439 dobj abnormalities,showed
R3765 T15442 T15439 punct ", ",showed
R3766 T15443 T15444 mark while,were
R3767 T15444 T15439 advcl were,showed
R3768 T15445 T15446 npadvmod Pygo1,homozygous
R3769 T15446 T15447 amod homozygous,mutants
R3770 T15447 T15444 nsubj mutants,were
R3771 T15448 T15444 acomp normal,were
R3772 T15449 T15448 cc and,normal
R3773 T15450 T15448 conj fertile,normal
R3774 T15451 T15435 punct .,developed
R3775 T15453 T15454 advmod Furthermore,was
R3776 T15455 T15454 punct ", ",was
R3777 T15456 T15454 expl there,was
R3778 T15457 T15458 det no,synergism
R3779 T15458 T15454 attr synergism,was
R3780 T15459 T15458 amod detected,synergism
R3781 T15460 T15458 prep in,synergism
R3782 T15461 T15462 det the,phenotype
R3783 T15462 T15460 pobj phenotype,in
R3784 T15463 T15462 prep of,phenotype
R3785 T15464 T15465 det the,mutant
R3786 T15465 T15463 pobj mutant,of
R3787 T15466 T15465 amod double,mutant
R3788 T15467 T15468 compound Pygo1,Pygo2
R3789 T15468 T15465 compound Pygo2,mutant
R3790 T15469 T15468 punct /,Pygo2
R3791 T15470 T15454 punct ", ",was
R3792 T15471 T15472 mark although,show
R3793 T15472 T15454 advcl show,was
R3794 T15473 T15472 prep in,show
R3795 T15474 T15475 amod several,tissues
R3796 T15475 T15473 pobj tissues,in
R3797 T15476 T15477 det the,reporter
R3798 T15477 T15472 nsubj reporter,show
R3799 T15478 T15479 compound BAT,gal
R3800 T15479 T15477 compound gal,reporter
R3801 T15480 T15479 punct -,gal
R3802 T15481 T15477 compound Wnt,reporter
R3803 T15482 T15472 aux did,show
R3804 T15483 T15472 advmod more,show
R3805 T15484 T15485 det a,reduction
R3806 T15485 T15472 dobj reduction,show
R3807 T15486 T15485 amod severe,reduction
R3808 T15487 T15485 prep in,reduction
R3809 T15488 T15487 pobj expression,in
R3810 T15489 T15454 punct .,was
R3811 T15491 T15492 nummod One,explanation
R3812 T15492 T15494 nsubj explanation,is
R3813 T15493 T15492 amod possible,explanation
R3814 T15495 T15492 prep of,explanation
R3815 T15496 T15497 det these,results
R3816 T15497 T15495 pobj results,of
R3817 T15498 T15497 amod unexpected,results
R3818 T15499 T15500 det a,failure
R3819 T15500 T15494 attr failure,is
R3820 T15501 T15500 prep of,failure
R3821 T15502 T15503 det the,gene
R3822 T15503 T15501 pobj gene,of
R3823 T15504 T15503 amod targeting,gene
R3824 T15505 T15506 aux to,eliminate
R3825 T15506 T15500 acl eliminate,failure
R3826 T15507 T15506 dobj functioning,eliminate
R3827 T15508 T15507 prep of,functioning
R3828 T15509 T15510 det the,genes
R3829 T15510 T15508 pobj genes,of
R3830 T15511 T15510 nmod Pygo1,genes
R3831 T15512 T15511 cc and,Pygo1
R3832 T15513 T15511 conj Pygo2,Pygo1
R3833 T15514 T15494 punct .,is
R3834 T15516 T15517 det The,alleles
R3835 T15517 T15520 nsubj alleles,are
R3836 T15518 T15519 compound Pygopus,deletion
R3837 T15519 T15517 compound deletion,alleles
R3838 T15521 T15517 acl described,alleles
R3839 T15522 T15521 prep in,described
R3840 T15523 T15524 det this,report
R3841 T15524 T15522 pobj report,in
R3842 T15525 T15520 punct ", ",are
R3843 T15526 T15520 advmod however,are
R3844 T15527 T15520 punct ", ",are
R3845 T15528 T15529 advmod almost,certainly
R3846 T15529 T15520 advmod certainly,are
R3847 T15530 T15531 amod functional,nulls
R3848 T15531 T15520 attr nulls,are
R3849 T15532 T15520 punct .,are
R3850 T15534 T15535 prep In,shown
R3851 T15536 T15534 pobj Drosophila,In
R3852 T15537 T15535 punct ", ",shown
R3853 T15538 T15535 nsubjpass it,shown
R3854 T15539 T15535 aux has,shown
R3855 T15540 T15535 auxpass been,shown
R3856 T15541 T15542 mark that,is
R3857 T15542 T15535 ccomp is,shown
R3858 T15543 T15544 det the,domain
R3859 T15544 T15542 nsubj domain,is
R3860 T15545 T15544 compound PHD,domain
R3861 T15546 T15547 advmod absolutely,necessary
R3862 T15547 T15542 acomp necessary,is
R3863 T15548 T15547 prep for,necessary
R3864 T15549 T15550 compound Pygopus,function
R3865 T15550 T15548 pobj function,for
R3866 T15551 T15550 prep in,function
R3867 T15552 T15553 compound Wg,signaling
R3868 T15553 T15551 pobj signaling,in
R3869 T15554 T15535 punct .,shown
R3870 T15556 T15557 det The,domain
R3871 T15557 T15559 nsubj domain,is
R3872 T15558 T15557 compound PHD,domain
R3873 T15560 T15561 nummod 60,acids
R3874 T15561 T15559 attr acids,is
R3875 T15562 T15561 compound amino,acids
R3876 T15563 T15561 prep with,acids
R3877 T15564 T15565 nummod seven,cysteines
R3878 T15565 T15563 pobj cysteines,with
R3879 T15566 T15565 cc and,cysteines
R3880 T15567 T15568 det a,histidine
R3881 T15568 T15565 conj histidine,cysteines
R3882 T15569 T15568 punct ", ",histidine
R3883 T15570 T15568 acl predicted,histidine
R3884 T15571 T15572 aux to,chelate
R3885 T15572 T15570 xcomp chelate,predicted
R3886 T15573 T15574 nummod two,ions
R3887 T15574 T15572 dobj ions,chelate
R3888 T15575 T15574 compound zinc,ions
R3889 T15576 T15559 punct .,is
R3890 T15578 T15579 compound PHD,domains
R3891 T15579 T15580 nsubjpass domains,found
R3892 T15581 T15580 auxpass are,found
R3893 T15582 T15580 prep in,found
R3894 T15583 T15584 amod diverse,proteins
R3895 T15584 T15582 pobj proteins,in
R3896 T15585 T15584 punct ", ",proteins
R3897 T15586 T15584 prep including,proteins
R3898 T15587 T15588 compound transcription,factors
R3899 T15588 T15586 pobj factors,including
R3900 T15589 T15580 punct ", ",found
R3901 T15590 T15580 cc and,found
R3902 T15591 T15592 aux have,implicated
R3903 T15592 T15580 conj implicated,found
R3904 T15593 T15592 auxpass been,implicated
R3905 T15594 T15592 prep in,implicated
R3906 T15595 T15596 compound chromatin,remodeling
R3907 T15596 T15594 pobj remodeling,in
R3908 T15597 T15596 cc and,remodeling
R3909 T15598 T15599 compound protein,protein
R3910 T15599 T15601 compound protein,interactions
R3911 T15600 T15599 punct -,protein
R3912 T15601 T15596 conj interactions,remodeling
R3913 T15602 T15603 punct [,8
R3914 T15603 T15592 parataxis 8,implicated
R3915 T15604 T15603 punct ],8
R3916 T15605 T15580 punct .,found
R3917 T15607 T15608 prep In,loses
R3918 T15609 T15607 pobj Drosophila,In
R3919 T15610 T15611 det the,allele
R3920 T15611 T15608 nsubj allele,loses
R3921 T15612 T15611 compound pygoF107,allele
R3922 T15613 T15611 punct ", ",allele
R3923 T15614 T15611 prep with,allele
R3924 T15615 T15616 det a,mutation
R3925 T15616 T15619 nsubj mutation,converting
R3926 T15617 T15616 amod single,mutation
R3927 T15618 T15616 compound missense,mutation
R3928 T15619 T15614 pcomp converting,with
R3929 T15620 T15621 compound amino,acid
R3930 T15621 T15619 dobj acid,converting
R3931 T15622 T15621 nummod 802,acid
R3932 T15623 T15621 prep in,acid
R3933 T15624 T15625 det the,domain
R3934 T15625 T15623 pobj domain,in
R3935 T15626 T15625 compound PHD,domain
R3936 T15627 T15619 prep from,converting
R3937 T15628 T15627 pobj cysteine,from
R3938 T15629 T15627 prep to,from
R3939 T15630 T15629 pobj tyrosine,to
R3940 T15631 T15608 punct ", ",loses
R3941 T15632 T15633 compound Wnt,signaling
R3942 T15633 T15634 compound signaling,function
R3943 T15634 T15608 dobj function,loses
R3944 T15635 T15608 prep in,loses
R3945 T15636 T15637 preconj both,embryogenesis
R3946 T15637 T15635 pobj embryogenesis,in
R3947 T15638 T15637 cc and,embryogenesis
R3948 T15639 T15640 amod imaginal,disc
R3949 T15640 T15641 compound disc,development
R3950 T15641 T15637 conj development,embryogenesis
R3951 T15642 T15643 punct [,8
R3952 T15643 T15608 parataxis 8,loses
R3953 T15644 T15643 punct ],8
R3954 T15645 T15608 punct .,loses
R3955 T15647 T15648 det The,alleles
R3956 T15648 T15653 nsubj alleles,carried
R3957 T15649 T15650 compound Pygo1,Pygo2
R3958 T15650 T15648 compound Pygo2,alleles
R3959 T15651 T15650 punct /,Pygo2
R3960 T15652 T15648 compound mutant,alleles
R3961 T15654 T15648 acl made,alleles
R3962 T15655 T15654 prep in,made
R3963 T15656 T15657 det this,report
R3964 T15657 T15655 pobj report,in
R3965 T15658 T15653 dobj deletions,carried
R3966 T15659 T15658 prep of,deletions
R3967 T15660 T15661 det the,domains
R3968 T15661 T15659 pobj domains,of
R3969 T15662 T15661 amod entire,domains
R3970 T15663 T15661 compound PHD,domains
R3971 T15664 T15661 punct ", ",domains
R3972 T15665 T15666 advmod as,as
R3973 T15666 T15661 cc as,domains
R3974 T15667 T15666 advmod well,as
R3975 T15668 T15669 amod most,sequences
R3976 T15669 T15661 conj sequences,domains
R3977 T15670 T15669 amod other,sequences
R3978 T15671 T15669 compound coding,sequences
R3979 T15672 T15653 punct .,carried
R3980 T15674 T15675 prep For,deleted
R3981 T15676 T15677 det the,gene
R3982 T15677 T15674 pobj gene,For
R3983 T15678 T15677 compound Pygo1,gene
R3984 T15679 T15675 punct ", ",deleted
R3985 T15680 T15681 det the,region
R3986 T15681 T15675 nsubjpass region,deleted
R3987 T15682 T15681 compound coding,region
R3988 T15683 T15681 prep for,region
R3989 T15684 T15685 quantmod 372,417
R3990 T15685 T15687 nummod 417,acids
R3991 T15686 T15685 quantmod of,417
R3992 T15687 T15683 pobj acids,for
R3993 T15688 T15687 amod total,acids
R3994 T15689 T15687 compound amino,acids
R3995 T15690 T15675 auxpass was,deleted
R3996 T15691 T15675 punct ", ",deleted
R3997 T15692 T15675 cc and,deleted
R3998 T15693 T15694 prep for,deleted
R3999 T15694 T15675 conj deleted,deleted
R4000 T15695 T15696 det the,gene
R4001 T15696 T15693 pobj gene,for
R4002 T15697 T15696 compound Pygo2,gene
R4003 T15698 T15694 punct ", ",deleted
R4004 T15699 T15694 nsubj we,deleted
R4005 T15700 T15694 dobj coding,deleted
R4006 T15701 T15700 prep for,coding
R4007 T15702 T15703 quantmod 354,405
R4008 T15703 T15705 nummod 405,acids
R4009 T15704 T15703 quantmod of,405
R4010 T15705 T15701 pobj acids,for
R4011 T15706 T15705 compound amino,acids
R4012 T15707 T15694 punct .,deleted
R4013 T15709 T15710 nsubj It,is
R4014 T15711 T15710 advmod therefore,is
R4015 T15712 T15713 advmod very,unlikely
R4016 T15713 T15710 acomp unlikely,is
R4017 T15714 T15715 mark that,were
R4018 T15715 T15710 ccomp were,is
R4019 T15716 T15717 det the,phenotypes
R4020 T15717 T15715 nsubj phenotypes,were
R4021 T15718 T15719 advmod relatively,mild
R4022 T15719 T15717 amod mild,phenotypes
R4023 T15720 T15717 acl observed,phenotypes
R4024 T15721 T15722 det the,result
R4025 T15722 T15715 attr result,were
R4026 T15723 T15722 prep of,result
R4027 T15724 T15725 amod residual,function
R4028 T15725 T15723 pobj function,of
R4029 T15726 T15725 prep of,function
R4030 T15727 T15728 det the,alleles
R4031 T15728 T15726 pobj alleles,of
R4032 T15729 T15728 amod targeted,alleles
R4033 T15730 T15710 punct .,is
R4034 T15732 T15733 nsubj We,focused
R4035 T15734 T15735 poss our,analysis
R4036 T15735 T15733 dobj analysis,focused
R4037 T15736 T15733 prep on,focused
R4038 T15737 T15738 det the,kidney
R4039 T15738 T15736 pobj kidney,on
R4040 T15739 T15738 amod developing,kidney
R4041 T15740 T15738 punct ", ",kidney
R4042 T15741 T15742 prep in,shown
R4043 T15742 T15738 relcl shown,kidney
R4044 T15743 T15741 pobj which,in
R4045 T15744 T15745 compound Wnt,signaling
R4046 T15745 T15742 nsubjpass signaling,shown
R4047 T15746 T15742 aux has,shown
R4048 T15747 T15742 auxpass been,shown
R4049 T15748 T15749 aux to,be
R4050 T15749 T15742 xcomp be,shown
R4051 T15750 T15749 prep of,be
R4052 T15751 T15752 amod critical,importance
R4053 T15752 T15750 pobj importance,of
R4054 T15753 T15749 prep in,be
R4055 T15754 T15755 amod several,stages
R4056 T15755 T15753 pobj stages,in
R4057 T15756 T15755 prep of,stages
R4058 T15757 T15756 pobj nephrogenesis,of
R4059 T15758 T15733 punct .,focused
R4060 T15760 T15761 nsubjpass Wnt9b,made
R4061 T15762 T15761 auxpass is,made
R4062 T15763 T15761 agent by,made
R4063 T15764 T15765 det the,bud
R4064 T15765 T15763 pobj bud,by
R4065 T15766 T15765 amod ureteric,bud
R4066 T15767 T15761 cc and,made
R4067 T15768 T15761 conj induces,made
R4068 T15769 T15770 det the,mesenchyme
R4069 T15770 T15768 dobj mesenchyme,induces
R4070 T15771 T15770 amod metanephric,mesenchyme
R4071 T15772 T15773 aux to,undergo
R4072 T15773 T15768 xcomp undergo,induces
R4073 T15774 T15773 dobj nephrogenesis,undergo
R4074 T15775 T15776 punct [,2
R4075 T15776 T15773 parataxis 2,undergo
R4076 T15777 T15776 punct ],2
R4077 T15778 T15761 punct .,made
R4078 T15780 T15781 advmod Downstream,is
R4079 T15782 T15780 prep of,Downstream
R4080 T15783 T15782 pobj Wnt9b,of
R4081 T15784 T15781 nsubj Wnt4,is
R4082 T15785 T15786 punct [,2
R4083 T15786 T15784 parataxis 2,Wnt4
R4084 T15787 T15786 punct ],2
R4085 T15788 T15784 punct ", ",Wnt4
R4086 T15789 T15790 dep which,made
R4087 T15790 T15784 relcl made,Wnt4
R4088 T15791 T15790 auxpass is,made
R4089 T15792 T15790 agent by,made
R4090 T15793 T15794 det the,mesenchyme
R4091 T15794 T15792 pobj mesenchyme,by
R4092 T15795 T15794 amod metanephric,mesenchyme
R4093 T15796 T15790 punct ", ",made
R4094 T15797 T15790 cc and,made
R4095 T15798 T15799 auxpass is,required
R4096 T15799 T15790 conj required,made
R4097 T15800 T15799 advmod also,required
R4098 T15801 T15799 prep for,required
R4099 T15802 T15801 pobj nephrogenesis,for
R4100 T15803 T15804 punct [,3
R4101 T15804 T15799 parataxis 3,required
R4102 T15805 T15804 punct ],3
R4103 T15806 T15781 punct .,is
R4104 T15808 T15809 prep In,produced
R4105 T15810 T15808 pobj addition,In
R4106 T15811 T15809 punct ", ",produced
R4107 T15812 T15809 nsubjpass Wnt11,produced
R4108 T15813 T15809 auxpass is,produced
R4109 T15814 T15809 agent by,produced
R4110 T15815 T15816 det the,tips
R4111 T15816 T15814 pobj tips,by
R4112 T15817 T15818 amod ureteric,bud
R4113 T15818 T15816 compound bud,tips
R4114 T15819 T15809 cc and,produced
R4115 T15820 T15809 conj induces,produced
R4116 T15821 T15822 compound GDNF,expression
R4117 T15822 T15820 dobj expression,induces
R4118 T15823 T15820 prep in,induces
R4119 T15824 T15825 det the,mesenchyme
R4120 T15825 T15823 pobj mesenchyme,in
R4121 T15826 T15825 amod metanephric,mesenchyme
R4122 T15827 T15828 punct [,4
R4123 T15828 T15820 parataxis 4,induces
R4124 T15829 T15828 punct ],4
R4125 T15830 T15809 punct .,produced
R4126 T15832 T15833 prep In,describe
R4127 T15834 T15835 det this,report
R4128 T15835 T15832 pobj report,In
R4129 T15836 T15833 nsubj we,describe
R4130 T15837 T15838 det a,function
R4131 T15838 T15833 dobj function,describe
R4132 T15839 T15838 amod novel,function
R4133 T15840 T15838 compound Wnt,function
R4134 T15841 T15838 prep in,function
R4135 T15842 T15843 compound kidney,development
R4136 T15843 T15841 pobj development,in
R4137 T15844 T15833 punct .,describe
R4138 T15846 T15847 det The,reporter
R4139 T15847 T15852 nsubj reporter,indicated
R4140 T15848 T15849 compound BAT,gal
R4141 T15849 T15851 compound gal,transgene
R4142 T15850 T15849 punct -,gal
R4143 T15851 T15847 compound transgene,reporter
R4144 T15853 T15854 det the,presence
R4145 T15854 T15852 dobj presence,indicated
R4146 T15855 T15854 prep of,presence
R4147 T15856 T15857 amod canonical,signaling
R4148 T15857 T15855 pobj signaling,of
R4149 T15858 T15857 compound Wnt,signaling
R4150 T15859 T15854 prep in,presence
R4151 T15860 T15861 det the,bud
R4152 T15861 T15859 pobj bud,in
R4153 T15862 T15861 amod ureteric,bud
R4154 T15863 T15854 cc and,presence
R4155 T15864 T15865 poss its,derivatives
R4156 T15865 T15854 conj derivatives,presence
R4157 T15866 T15865 prep in,derivatives
R4158 T15867 T15868 det the,kidney
R4159 T15868 T15866 pobj kidney,in
R4160 T15869 T15868 amod developing,kidney
R4161 T15870 T15852 punct .,indicated
R4162 T15872 T15873 advmod Further,lost
R4163 T15874 T15873 punct ", ",lost
R4164 T15875 T15873 prep in,lost
R4165 T15876 T15877 det the,mutants
R4166 T15877 T15875 pobj mutants,in
R4167 T15878 T15877 compound Pygo2,mutants
R4168 T15879 T15880 det this,signal
R4169 T15880 T15873 nsubjpass signal,lost
R4170 T15881 T15873 auxpass was,lost
R4171 T15882 T15873 punct ", ",lost
R4172 T15883 T15873 advcl suggesting,lost
R4173 T15884 T15885 amod significant,reduction
R4174 T15885 T15883 dobj reduction,suggesting
R4175 T15993 T15983 acomp similar,is
R4176 T15994 T15993 prep to,similar
R4177 T15995 T15994 pobj that,to
R4178 T15996 T15997 advmod previously,reported
R4179 T15997 T15995 acl reported,that
R4180 T15998 T15997 prep for,reported
R4181 T15999 T16000 compound Wnt11,mutants
R4182 T16000 T15998 pobj mutants,for
R4183 T16001 T16002 punct [,4
R4184 T16002 T15983 parataxis 4,is
R4185 T16003 T16002 punct ],4
R4186 T16004 T15983 punct .,is
R4187 T16006 T16007 det The,mechanisms
R4188 T16007 T16009 nsubj mechanisms,are
R4189 T16008 T16007 amod underlying,mechanisms
R4190 T15886 T15885 prep of,reduction
R4191 T16010 T16009 punct ", ",are
R4192 T15887 T15888 compound Wnt,signaling
R4193 T15888 T15886 pobj signaling,of
R4194 T16011 T16009 advmod however,are
R4195 T15889 T15873 punct .,lost
R4196 T16012 T16009 punct ", ",are
R4197 T15891 T15892 prep In,observed
R4198 T15893 T15891 pobj addition,In
R4199 T16013 T16009 acomp likely,are
R4200 T15894 T15892 punct ", ",observed
R4201 T15895 T15892 nsubj we,observed
R4202 T15896 T15897 det a,decrease
R4203 T16014 T16015 aux to,be
R4204 T15897 T15892 dobj decrease,observed
R4205 T15898 T15897 amod resulting,decrease
R4206 T16015 T16013 xcomp be,likely
R4207 T15899 T15897 prep in,decrease
R4208 T15900 T15901 amod ureteric,tip
R4209 T15901 T15902 compound tip,density
R4210 T16016 T16015 acomp distinct,be
R4211 T15902 T15899 pobj density,in
R4212 T15903 T15897 punct ", ",decrease
R4213 T15904 T15905 amod reduced,size
R4214 T16017 T16009 punct .,are
R4215 T15905 T15897 conj size,decrease
R4216 T15906 T15905 compound kidney,size
R4217 T15907 T15905 cc and,size
R4218 T16019 T16020 nsubjpass Wnt11,thought
R4219 T15908 T15909 amod altered,morphology
R4220 T15909 T15905 conj morphology,size
R4221 T15910 T15909 prep of,morphology
R4222 T15911 T15912 det the,tree
R4223 T16021 T16020 auxpass is,thought
R4224 T15912 T15910 pobj tree,of
R4225 T15913 T15912 amod ureteric,tree
R4226 T15914 T15892 prep in,observed
R4227 T15915 T15914 pobj mutants,in
R4228 T16022 T16020 advmod generally,thought
R4229 T15916 T15892 punct ", ",observed
R4230 T15917 T15892 advcl indicating,observed
R4231 T16023 T16024 aux to,act
R4232 T15918 T15919 det a,role
R4233 T15919 T15917 dobj role,indicating
R4234 T15920 T15919 prep for,role
R4235 T16024 T16020 xcomp act,thought
R4236 T15921 T15922 amod canonical,signaling
R4237 T15922 T15920 pobj signaling,for
R4238 T15923 T15922 compound Wnt,signaling
R4239 T15924 T15919 prep in,role
R4240 T16025 T16024 prep through,act
R4241 T15925 T15926 amod branching,morphogenesis
R4242 T15926 T15924 pobj morphogenesis,in
R4243 T15927 T15926 prep of,morphogenesis
R4244 T15928 T15929 det the,bud
R4245 T15929 T15927 pobj bud,of
R4246 T15930 T15929 amod ureteric,bud
R4247 T16026 T16027 det a,pathway
R4248 T15931 T15892 punct .,observed
R4249 T15933 T15934 mark While,is
R4250 T16027 T16025 pobj pathway,through
R4251 T15934 T15938 advcl is,remains
R4252 T15935 T15936 det the,interpretation
R4253 T15936 T15934 nsubj interpretation,is
R4254 T16028 T16027 amod noncanonical,pathway
R4255 T15937 T15936 amod simplest,interpretation
R4256 T16029 T16024 punct ", ",act
R4257 T15939 T15940 amod direct,signaling
R4258 T15940 T15934 attr signaling,is
R4259 T15941 T15940 compound Wnt,signaling
R4260 T16030 T16024 punct (,act
R4261 T15942 T15940 prep to,signaling
R4262 T15943 T15944 det the,bud
R4263 T15944 T15942 pobj bud,to
R4264 T16031 T16032 mark although,noted
R4265 T15945 T15944 amod ureteric,bud
R4266 T15946 T15938 punct ", ",remains
R4267 T16032 T16024 advcl noted,act
R4268 T15947 T15938 nsubj it,remains
R4269 T15948 T15938 oprd possible,remains
R4270 T15949 T15950 mark that,are
R4271 T16033 T16032 nsubjpass exceptions,noted
R4272 T15950 T15938 ccomp are,remains
R4273 T15951 T15952 det the,abnormalities
R4274 T15952 T15950 nsubj abnormalities,are
R4275 T16034 T16032 aux have,noted
R4276 T15953 T15952 amod observed,abnormalities
R4277 T15954 T15955 det the,result
R4278 T16035 T16032 auxpass been,noted
R4279 T15955 T15950 attr result,are
R4280 T15956 T15955 prep of,result
R4281 T15957 T15958 amod indirect,effects
R4282 T16036 T16037 punct [,31
R4283 T16037 T16032 parataxis 31,noted
R4284 T15958 T15956 pobj effects,of
R4285 T16038 T16037 punct ],31
R4286 T15959 T15950 punct ", ",are
R4287 T15960 T15950 prep with,are
R4288 T16039 T16024 punct ),act
R4289 T15961 T15962 amod altered,signaling
R4290 T15962 T15964 nsubj signaling,affecting
R4291 T16040 T16024 punct ", ",act
R4292 T15963 T15962 compound Wnt,signaling
R4293 T15964 T15960 pcomp affecting,with
R4294 T16041 T16042 mark whereas,promote
R4295 T15965 T15962 prep to,signaling
R4296 T15966 T15967 det the,mesenchyme
R4297 T15967 T15965 pobj mesenchyme,to
R4298 T15968 T15967 amod metanephric,mesenchyme
R4299 T15969 T15964 advmod then,affecting
R4300 T15970 T15964 dobj mesenchyme,affecting
R4301 T16042 T16024 advcl promote,act
R4302 T15971 T15970 prep to,mesenchyme
R4303 T15972 T15973 amod ureteric,bud
R4304 T15973 T15974 compound bud,signaling
R4305 T16043 T16044 det the,genes
R4306 T15974 T15971 pobj signaling,to
R4307 T15975 T15938 punct .,remains
R4308 T16044 T16042 nsubj genes,promote
R4309 T15977 T15978 det The,phenotype
R4310 T15978 T15983 nsubj phenotype,is
R4311 T15979 T15980 compound Pygo1,Pygo2
R4312 T16045 T16044 compound Pygopus,genes
R4313 T15980 T15982 compound Pygo2,mutant
R4314 T15981 T15980 punct /,Pygo2
R4315 T16046 T16047 amod canonical,signaling
R4316 T15982 T15978 compound mutant,phenotype
R4317 T15984 T15978 prep of,phenotype
R4318 T16047 T16042 dobj signaling,promote
R4319 T15985 T15986 amod reduced,morphogenesis
R4320 T15986 T15984 pobj morphogenesis,of
R4321 T15987 T15986 compound branching,morphogenesis
R4322 T16048 T16047 compound Wnt,signaling
R4323 T15988 T15986 prep of,morphogenesis
R4324 T15989 T15990 det the,bud
R4325 T15990 T15988 pobj bud,of
R4326 T16049 T16020 punct .,thought
R4327 T15991 T15990 amod ureteric,bud
R4328 T15992 T15993 advmod surprisingly,similar
R4329 T16051 T16052 advmod Further,showed
R4330 T16053 T16052 punct ", ",showed
R4331 T16054 T16055 det the,mutants
R4332 T16055 T16052 nsubj mutants,showed
R4333 T16056 T16055 compound Wnt11,mutants
R4334 T16100 T16101 det The,mutants
R4335 T16057 T16058 det an,loop
R4336 T16101 T16105 nsubj mutants,showed
R4337 T16102 T16101 nmod Pygo1,mutants
R4338 T16058 T16052 dobj loop,showed
R4339 T16103 T16102 punct /,Pygo1
R4340 T16104 T16102 nummod 2,Pygo1
R4341 T16059 T16058 amod altered,loop
R4342 T16106 T16105 advmod also,showed
R4343 T16107 T16108 det an,expansion
R4344 T16108 T16105 dobj expansion,showed
R4345 T16060 T16058 compound feedback,loop
R4346 T16109 T16108 prep of,expansion
R4347 T16110 T16111 det the,zone
R4348 T16111 T16109 pobj zone,of
R4349 T16112 T16111 prep of,zone
R4350 T16113 T16114 amod thickened,mesenchyme
R4351 T16061 T16058 prep between,loop
R4352 T16062 T16063 compound Wnt,signaling
R4353 T16114 T16112 pobj mesenchyme,of
R4354 T16063 T16061 pobj signaling,between
R4355 T16115 T16116 dep that,caps
R4356 T16064 T16063 prep from,signaling
R4357 T16116 T16111 relcl caps,zone
R4358 T16117 T16118 det the,bud
R4359 T16118 T16116 dobj bud,caps
R4360 T16065 T16066 det the,bud
R4361 T16119 T16118 amod ureteric,bud
R4362 T16120 T16105 punct .,showed
R4363 T16066 T16064 pobj bud,from
R4364 T16122 T16123 advmod Nevertheless,formed
R4365 T16067 T16066 amod ureteric,bud
R4366 T16124 T16123 punct ", ",formed
R4367 T16125 T16126 det the,mesenchyme
R4368 T16126 T16123 nsubj mesenchyme,formed
R4369 T16068 T16064 prep to,from
R4370 T16127 T16126 nmod mutant,mesenchyme
R4371 T16128 T16126 amod metanephric,mesenchyme
R4372 T16069 T16070 det the,mesenchyme
R4373 T16129 T16123 dobj nephrons,formed
R4374 T16130 T16123 advmod normally,formed
R4375 T16131 T16123 punct .,formed
R4376 T16070 T16068 pobj mesenchyme,to
R4377 T16071 T16063 cc and,signaling
R4378 T16133 T16134 nsubj This,was
R4379 T16072 T16073 compound GDNF,signaling
R4380 T16135 T16136 advmod particularly,interesting
R4381 T16073 T16063 conj signaling,signaling
R4382 T16136 T16134 acomp interesting,was
R4383 T16137 T16134 punct ", ",was
R4384 T16138 T16139 mark as,shown
R4385 T16074 T16073 prep from,signaling
R4386 T16139 T16134 advcl shown,was
R4387 T16075 T16076 det the,mesenchyme
R4388 T16140 T16141 compound Wnt9b,signaling
R4389 T16141 T16139 nsubjpass signaling,shown
R4390 T16142 T16141 prep from,signaling
R4391 T16076 T16074 pobj mesenchyme,from
R4392 T16143 T16144 det the,bud
R4393 T16144 T16142 pobj bud,from
R4394 T16145 T16144 amod ureteric,bud
R4395 T16077 T16074 prep to,from
R4396 T16146 T16142 prep to,from
R4397 T16147 T16148 det the,mesenchyme
R4398 T16078 T16079 det the,bud
R4399 T16148 T16146 pobj mesenchyme,to
R4400 T16149 T16148 amod metanephric,mesenchyme
R4401 T16150 T16139 aux has,shown
R4402 T16151 T16139 auxpass been,shown
R4403 T16152 T16153 aux to,induce
R4404 T16153 T16139 xcomp induce,shown
R4405 T16079 T16077 pobj bud,to
R4406 T16154 T16153 dobj nephrogenesis,induce
R4407 T16155 T16153 prep via,induce
R4408 T16156 T16157 amod canonical,signaling
R4409 T16080 T16052 punct ", ",showed
R4410 T16157 T16155 pobj signaling,via
R4411 T16158 T16157 compound Wnt,signaling
R4412 T16159 T16160 punct [,2
R4413 T16081 T16082 mark whereas,observed
R4414 T16160 T16153 parataxis 2,induce
R4415 T16161 T16160 punct ],2
R4416 T16162 T16134 punct .,was
R4417 T16082 T16052 advcl observed,showed
R4418 T16164 T16165 det The,results
R4419 T16083 T16082 prep in,observed
R4420 T16165 T16166 nsubj results,indicate
R4421 T16167 T16165 prep in,results
R4422 T16084 T16085 det the,mutants
R4423 T16168 T16169 det this,report
R4424 T16169 T16167 pobj report,in
R4425 T16170 T16171 det a,divergence
R4426 T16085 T16083 pobj mutants,in
R4427 T16171 T16166 dobj divergence,indicate
R4428 T16172 T16171 amod striking,divergence
R4429 T16173 T16172 cc and,striking
R4430 T16086 T16087 compound Pygo1,Pygo2
R4431 T16174 T16172 conj surprising,striking
R4432 T16175 T16171 amod evolutionary,divergence
R4433 T16176 T16171 prep of,divergence
R4434 T16087 T16085 compound Pygo2,mutants
R4435 T16177 T16178 compound Pygopus,function
R4436 T16178 T16176 pobj function,of
R4437 T16088 T16087 punct /,Pygo2
R4438 T16179 T16171 prep between,divergence
R4439 T16180 T16179 pobj Drosophila,between
R4440 T16181 T16180 cc and,Drosophila
R4441 T16089 T16082 punct ", ",observed
R4442 T16182 T16180 conj mammals,Drosophila
R4443 T16183 T16166 punct .,indicate
R4444 T16090 T16082 nsubj we,observed
R4445 T16185 T16186 prep In,required
R4446 T16091 T16092 amod disrupted,signaling
R4447 T16187 T16185 pobj Drosophila,In
R4448 T16188 T16186 punct ", ",required
R4449 T16092 T16082 dobj signaling,observed
R4450 T16189 T16190 det the,gene
R4451 T16190 T16186 nsubjpass gene,required
R4452 T16191 T16190 compound Pygopus,gene
R4453 T16192 T16186 auxpass is,required
R4454 T16193 T16186 advmod often,required
R4455 T16194 T16186 prep for,required
R4456 T16093 T16092 compound Wnt,signaling
R4457 T16195 T16196 amod canonical,signaling
R4458 T16196 T16194 pobj signaling,for
R4459 T16197 T16196 compound Wnt,signaling
R4460 T16094 T16082 prep in,observed
R4461 T16198 T16186 punct ", ",required
R4462 T16199 T16200 mark while,appear
R4463 T16200 T16186 advcl appear,required
R4464 T16095 T16096 det the,bud
R4465 T16201 T16200 prep in,appear
R4466 T16202 T16201 pobj mammals,in
R4467 T16096 T16094 pobj bud,in
R4468 T16203 T16204 det the,genes
R4469 T16204 T16200 nsubj genes,appear
R4470 T16097 T16096 amod ureteric,bud
R4471 T16098 T16052 punct .,showed
R4472 T16311 T16312 amod essential,components
R4473 T16205 T16206 compound Pygo1,Pygo2
R4474 T16206 T16204 compound Pygo2,genes
R4475 T16312 T16302 conj components,modulators
R4476 T16207 T16206 punct /,Pygo2
R4477 T16208 T16209 aux to,play
R4478 T16313 T16290 punct .,suggest
R4479 T16209 T16200 xcomp play,appear
R4480 T16210 T16211 det a,role
R4481 T16211 T16209 dobj role,play
R4482 T16315 T16316 det The,results
R4483 T16212 T16211 amod smaller,role
R4484 T16213 T16209 prep in,play
R4485 T16214 T16215 amod canonical,signaling
R4486 T16215 T16213 pobj signaling,in
R4487 T16316 T16318 nsubj results,support
R4488 T16216 T16215 compound Wnt,signaling
R4489 T16217 T16186 punct .,required
R4490 T16317 T16316 compound microarray,results
R4491 T16219 T16220 det The,reporter
R4492 T16319 T16318 advmod further,support
R4493 T16220 T16225 nsubj reporter,showed
R4494 T16320 T16321 det this,conclusion
R4495 T16221 T16222 compound BAT,gal
R4496 T16222 T16224 compound gal,transgene
R4497 T16321 T16318 dobj conclusion,support
R4498 T16223 T16222 punct -,gal
R4499 T16224 T16220 compound transgene,reporter
R4500 T16322 T16318 punct .,support
R4501 T16226 T16220 prep of,reporter
R4502 T16227 T16228 amod canonical,signaling
R4503 T16324 T16325 mark Whereas,monitors
R4504 T16228 T16226 pobj signaling,of
R4505 T16229 T16228 compound Wnt,signaling
R4506 T16230 T16231 amod reduced,signal
R4507 T16231 T16225 dobj signal,showed
R4508 T16232 T16230 cc but,reduced
R4509 T16233 T16232 advmod generally,but
R4510 T16234 T16232 neg not,but
R4511 T16325 T16332 advcl monitors,allows
R4512 T16235 T16230 conj absent,reduced
R4513 T16236 T16231 prep in,signal
R4514 T16326 T16327 det the,reporter
R4515 T16237 T16238 compound Pygo1,Pygo2
R4516 T16238 T16240 compound Pygo2,embryos
R4517 T16239 T16238 punct /,Pygo2
R4518 T16327 T16325 nsubj reporter,monitors
R4519 T16240 T16236 pobj embryos,in
R4520 T16241 T16240 compound mutant,embryos
R4521 T16242 T16231 punct ", ",signal
R4522 T16328 T16329 compound BAT,gal
R4523 T16243 T16231 prep with,signal
R4524 T16244 T16245 npadvmod tissue,specific
R4525 T16245 T16247 amod specific,variation
R4526 T16329 T16331 compound gal,transgene
R4527 T16246 T16245 punct -,specific
R4528 T16247 T16243 pobj variation,with
R4529 T16248 T16247 prep in,variation
R4530 T16330 T16329 punct -,gal
R4531 T16249 T16248 pobj level,in
R4532 T16250 T16249 prep of,level
R4533 T16251 T16250 pobj diminution,of
R4534 T16331 T16327 compound transgene,reporter
R4535 T16252 T16225 punct .,showed
R4536 T16333 T16334 det the,level
R4537 T16254 T16255 prep In,were
R4538 T16256 T16254 pobj addition,In
R4539 T16257 T16255 punct ", ",were
R4540 T16334 T16325 dobj level,monitors
R4541 T16258 T16259 det the,kidneys
R4542 T16259 T16255 nsubj kidneys,were
R4543 T16260 T16255 neg not,were
R4544 T16335 T16334 compound expression,level
R4545 T16261 T16255 acomp unique,were
R4546 T16262 T16255 prep in,were
R4547 T16263 T16262 pcomp showing,in
R4548 T16336 T16334 prep of,level
R4549 T16264 T16265 advmod surprisingly,normal
R4550 T16265 T16266 amod normal,development
R4551 T16266 T16263 dobj development,showing
R4552 T16337 T16338 advmod only,one
R4553 T16267 T16266 prep in,development
R4554 T16268 T16269 compound Pygo1,Pygo2
R4555 T16269 T16271 compound Pygo2,mutants
R4556 T16270 T16269 punct /,Pygo2
R4557 T16271 T16267 pobj mutants,in
R4558 T16272 T16255 punct .,were
R4559 T16338 T16339 nummod one,promoter
R4560 T16274 T16275 advmod Indeed,proceeded
R4561 T16339 T16336 pobj promoter,of
R4562 T16276 T16275 punct ", ",proceeded
R4563 T16277 T16275 nsubj organogenesis,proceeded
R4564 T16278 T16275 advmod generally,proceeded
R4565 T16340 T16341 npadvmod Wnt,responsive
R4566 T16279 T16275 prep without,proceeded
R4567 T16280 T16281 amod detectable,abnormality
R4568 T16281 T16279 pobj abnormality,without
R4569 T16341 T16339 amod responsive,promoter
R4570 T16282 T16275 punct ", ",proceeded
R4571 T16283 T16275 prep with,proceeded
R4572 T16342 T16332 punct ", ",allows
R4573 T16284 T16285 amod few,exceptions
R4574 T16285 T16283 pobj exceptions,with
R4575 T16286 T16275 punct .,proceeded
R4576 T16343 T16344 det the,microarray
R4577 T16288 T16289 det These,results
R4578 T16289 T16290 nsubj results,suggest
R4579 T16344 T16332 nsubj microarray,allows
R4580 T16291 T16292 mark that,are
R4581 T16345 T16346 det the,analysis
R4582 T16292 T16290 ccomp are,suggest
R4583 T16293 T16294 det the,proteins
R4584 T16294 T16292 nsubj proteins,are
R4585 T16346 T16332 dobj analysis,allows
R4586 T16295 T16294 acl encoded,proteins
R4587 T16296 T16295 agent by,encoded
R4588 T16297 T16298 amod mammalian,genes
R4589 T16298 T16296 pobj genes,by
R4590 T16347 T16346 prep of,analysis
R4591 T16299 T16298 compound Pygopus,genes
R4592 T16300 T16292 advmod often,are
R4593 T16348 T16349 det the,levels
R4594 T16301 T16302 amod mere,modulators
R4595 T16302 T16292 attr modulators,are
R4596 T16303 T16302 prep of,modulators
R4597 T16349 T16347 pobj levels,of
R4598 T16304 T16305 amod canonical,signaling
R4599 T16305 T16307 compound signaling,intensity
R4600 T16306 T16305 compound Wnt,signaling
R4601 T16350 T16349 compound activity,levels
R4602 T16307 T16303 pobj intensity,of
R4603 T16351 T16349 prep of,levels
R4604 T16352 T16351 pobj promoters,of
R4605 T16308 T16302 punct ", ",modulators
R4606 T16309 T16302 cc and,modulators
R4607 T16310 T16309 neg not,and
R4608 T16353 T16352 prep of,promoters
R4609 T16354 T16355 det all,genes
R4610 T16355 T16353 pobj genes,of
R4612 T16356 T16332 punct .,allows
R4615 T16358 T16359 advmod Interestingly,showed
R4620 T16360 T16359 punct ", ",showed
R4623 T16426 T16422 prep in,shown
R4624 T16427 T16426 pobj Drosophila,in
R4625 T16361 T16362 det the,kidneys
R4626 T16428 T16407 punct ", ",represent
R4627 T16429 T16430 det the,genes
R4628 T16362 T16359 nsubj kidneys,showed
R4629 T16430 T16407 nsubj genes,represent
R4630 T16431 T16430 prep with,genes
R4631 T16432 T16433 compound expression,differences
R4632 T16363 T16362 compound mutant,kidneys
R4633 T16433 T16431 pobj differences,with
R4634 T16434 T16435 compound candidate,targets
R4635 T16364 T16365 compound gene,expression
R4636 T16435 T16407 dobj targets,represent
R4637 T16436 T16435 compound Wnt,targets
R4638 T16437 T16435 punct (,targets
R4639 T16365 T16367 compound expression,profiles
R4640 T16438 T16435 amod direct,targets
R4641 T16439 T16438 cc or,direct
R4642 T16440 T16438 conj indirect,direct
R4643 T16366 T16365 punct -,expression
R4644 T16441 T16435 punct ),targets
R4645 T16442 T16435 prep in,targets
R4646 T16443 T16444 compound kidney,development
R4647 T16367 T16359 dobj profiles,showed
R4648 T16444 T16442 pobj development,in
R4649 T16445 T16407 punct .,represent
R4650 T16368 T16369 advmod surprisingly,similar
R4651 T16447 T16448 nsubj We,predict
R4652 T16369 T16367 amod similar,profiles
R4653 T16449 T16448 aux would,predict
R4654 T16450 T16451 det these,genes
R4655 T16370 T16369 prep to,similar
R4656 T16451 T16448 dobj genes,predict
R4657 T16452 T16453 aux to,show
R4658 T16453 T16448 xcomp show,predict
R4659 T16371 T16372 amod wild,type
R4660 T16454 T16455 amod greater,changes
R4661 T16455 T16453 dobj changes,show
R4662 T16456 T16455 prep in,changes
R4663 T16457 T16458 compound expression,level
R4664 T16458 T16456 pobj level,in
R4665 T16459 T16455 prep in,changes
R4666 T16372 T16370 pobj type,to
R4667 T16460 T16461 det a,kidney
R4668 T16461 T16459 pobj kidney,in
R4669 T16462 T16461 amod developing,kidney
R4670 T16373 T16359 punct .,showed
R4671 T16463 T16453 prep with,show
R4672 T16464 T16465 det a,removal
R4673 T16465 T16463 pobj removal,with
R4674 T16375 T16376 det Some,genes
R4675 T16466 T16467 advmod more,complete
R4676 T16467 T16465 amod complete,removal
R4677 T16468 T16465 prep of,removal
R4678 T16376 T16377 nsubj genes,show
R4679 T16469 T16470 amod canonical,signaling
R4680 T16470 T16468 pobj signaling,of
R4681 T16471 T16470 compound Wnt,signaling
R4682 T16378 T16377 aux did,show
R4683 T16472 T16448 punct .,predict
R4684 T16379 T16377 punct ", ",show
R4685 T16380 T16377 advmod however,show
R4686 T16381 T16377 punct ", ",show
R4687 T16382 T16383 compound expression,differences
R4688 T16383 T16377 dobj differences,show
R4689 T16384 T16377 punct ", ",show
R4690 T16385 T16377 cc and,show
R4691 T16386 T16387 det a,percentage
R4692 T16387 T16389 nsubjpass percentage,validated
R4693 T16388 T16387 amod high,percentage
R4694 T16389 T16377 conj validated,show
R4695 T16390 T16387 prep of,percentage
R4696 T16391 T16392 det these,differences
R4697 T16392 T16390 pobj differences,of
R4698 T16393 T16389 aux could,validated
R4699 T16394 T16389 auxpass be,validated
R4700 T16395 T16389 prep by,validated
R4701 T16396 T16397 amod real,time
R4702 T16397 T16399 compound time,PCR
R4703 T16398 T16397 punct -,time
R4704 T16399 T16395 pobj PCR,by
R4705 T16400 T16399 prep with,PCR
R4706 T16401 T16402 amod independent,samples
R4707 T16402 T16400 pobj samples,with
R4708 T16403 T16402 amod biological,samples
R4709 T16404 T16389 punct .,validated
R4710 T16406 T16407 advcl Assuming,represent
R4711 T16408 T16409 mark that,dedicated
R4712 T16409 T16406 ccomp dedicated,Assuming
R4713 T16410 T16411 det the,genes
R4714 T16411 T16409 nsubjpass genes,dedicated
R4715 T16412 T16411 compound Pygopus,genes
R4716 T16413 T16411 prep in,genes
R4717 T16414 T16413 pobj mammals,in
R4718 T16415 T16409 auxpass are,dedicated
R4719 T16416 T16409 prep to,dedicated
R4723 T17129 T17130 prep In,required
R4724 T17131 T17129 pobj conclusion,In
R4725 T17132 T17130 punct ", ",required
R4726 T17133 T17134 det the,gene
R4727 T17134 T17130 nsubjpass gene,required
R4728 T17135 T17134 amod mammalian,gene
R4729 T17136 T17134 compound Pygo2,gene
R4730 T17137 T17130 auxpass is,required
R4731 T17138 T17130 prep for,required
R4732 T17139 T17140 amod normal,morphogenesis
R4733 T17140 T17138 pobj morphogenesis,for
R4734 T17141 T17140 compound branching,morphogenesis
R4735 T17142 T17140 prep of,morphogenesis
R4736 T17143 T17144 det the,bud
R4737 T17144 T17142 pobj bud,of
R4738 T17145 T17144 amod ureteric,bud
R4739 T17146 T17130 punct ", ",required
R4740 T17147 T17130 prep with,required
R4741 T17148 T17149 nsubj mutants,showing
R4742 T17149 T17147 pcomp showing,with
R4743 T17150 T17151 amod dilated,tips
R4744 T17151 T17149 dobj tips,showing
R4745 T17152 T17151 cc and,tips
R4746 T17153 T17154 amod reduced,numbers
R4747 T17154 T17151 conj numbers,tips
R4748 T17155 T17154 prep of,numbers
R4749 T17156 T17155 pobj tips,of
R4750 T17157 T17130 punct .,required
R4751 T17159 T17160 prep In,was
R4752 T17161 T17159 pobj addition,In
R4753 T17162 T17160 punct ", ",was
R4754 T17163 T17160 prep in,was
R4755 T17164 T17165 compound Pygo2,mutants
R4756 T17165 T17163 pobj mutants,in
R4757 T17166 T17160 expl there,was
R4758 T17167 T17168 det an,expansion
R4759 T17168 T17160 attr expansion,was
R4760 T17169 T17168 prep of,expansion
R4761 T17170 T17171 det the,zone
R4762 T17171 T17169 pobj zone,of
R4763 T17172 T17171 prep of,zone
R4764 T17173 T17174 amod metanephric,mesenchyme
R4765 T17174 T17172 pobj mesenchyme,of
R4766 T17175 T17176 dep that,caps
R4767 T17176 T17171 relcl caps,zone
R4768 T17177 T17178 det the,buds
R4769 T17178 T17176 dobj buds,caps
R4770 T17179 T17178 amod ureteric,buds
R4771 T17180 T17160 punct .,was
R4772 T17182 T17183 advmod Nevertheless,proceeded
R4773 T17184 T17183 punct ", ",proceeded
R4774 T17185 T17186 compound nephron,formation
R4775 T17186 T17183 nsubj formation,proceeded
R4776 T17187 T17188 advmod remarkably,normally
R4777 T17188 T17183 advmod normally,proceeded
R4778 T17189 T17183 punct ", ",proceeded
R4779 T17190 T17191 advmod even,in
R4780 T17191 T17183 prep in,proceeded
R4781 T17192 T17193 compound Pygo1,Pygo2
R4782 T17193 T17195 npadvmod Pygo2,homozygous
R4783 T17194 T17193 punct /,Pygo2
R4784 T17195 T17198 amod homozygous,mutants
R4785 T17196 T17195 amod double,homozygous
R4786 T17197 T17195 punct -,homozygous
R4787 T17198 T17191 pobj mutants,in
R4788 T17199 T17183 punct .,proceeded
R4789 T17201 T17202 nsubj This,was
R4790 T17203 T17202 acomp surprising,was
R4791 T17204 T17202 advcl considering,was
R4792 T17205 T17206 det the,importance
R4793 T17206 T17204 dobj importance,considering
R4794 T17207 T17206 prep of,importance
R4795 T17208 T17209 det the,gene
R4796 T17209 T17207 pobj gene,of
R4797 T17210 T17209 compound Pygopus,gene
R4798 T17211 T17206 prep in,importance
R4799 T17212 T17213 amod canonical,signaling
R4800 T17213 T17211 pobj signaling,in
R4801 T17214 T17213 compound Wnt,signaling
R4802 T17215 T17206 prep in,importance
R4803 T17216 T17215 pobj Drosophila,in
R4804 T17217 T17206 punct ", ",importance
R4805 T17218 T17206 cc and,importance
R4806 T17219 T17220 det the,importance
R4807 T17220 T17206 conj importance,importance
R4808 T17221 T17220 prep of,importance
R4809 T17222 T17223 amod canonical,signaling
R4810 T17223 T17221 pobj signaling,of
R4811 T17224 T17223 compound Wnt,signaling
R4812 T17225 T17220 prep in,importance
R4813 T17226 T17225 pobj nephrogenesis,in
R4814 T17227 T17202 punct .,was
R4815 T17229 T17230 det The,results
R4816 T17230 T17231 nsubj results,argue
R4817 T17232 T17233 mark that,are
R4818 T17233 T17231 ccomp are,argue
R4819 T17234 T17235 det the,genes
R4820 T17235 T17233 nsubj genes,are
R4821 T17236 T17235 amod mammalian,genes
R4822 T17237 T17235 compound Pygopus,genes
R4823 T17238 T17233 punct ", ",are
R4824 T17239 T17233 prep in,are
R4825 T17240 T17241 amod most,systems
R4826 T17241 T17239 pobj systems,in
R4827 T17242 T17241 amod developing,systems
R4828 T17243 T17233 punct ", ",are
R4829 T17244 T17245 advmod only,transducers
R4830 T17245 T17233 attr transducers,are
R4831 T17246 T17245 amod quantitative,transducers
R4832 T17247 T17245 prep of,transducers
R4833 T17248 T17249 compound Wnt,signaling
R4834 T17249 T17247 pobj signaling,of
R4835 T17250 T17231 punct .,argue
R4836 T17252 T17253 amod Previous,studies
R4837 T17253 T17256 nsubj studies,confirm
R4838 T17254 T17255 compound cell,culture
R4839 T17255 T17253 compound culture,studies
R4840 T17257 T17258 punct [,33
R4841 T17258 T17253 parataxis 33,studies
R4842 T17259 T17258 nummod 32,33
R4843 T17260 T17258 punct ",",33
R4844 T17261 T17258 punct ],33
R4845 T17262 T17253 cc and,studies
R4846 T17263 T17264 det the,expression
R4847 T17264 T17253 conj expression,studies
R4848 T17265 T17264 amod reduced,expression
R4849 T17266 T17267 compound BAT,gal
R4850 T17267 T17269 compound gal,transgene
R4851 T17268 T17267 punct -,gal
R4852 T17269 T17270 compound transgene,reporter
R4853 T17270 T17264 compound reporter,expression
R4854 T17271 T17253 prep in,studies
R4855 T17272 T17273 det the,mice
R4856 T17273 T17271 pobj mice,in
R4857 T17274 T17275 compound Pygo1,Pygo2
R4858 T17275 T17277 compound Pygo2,knockout
R4859 T17276 T17275 punct /,Pygo2
R4860 T17277 T17273 compound knockout,mice
R4861 T17278 T17273 acl described,mice
R4862 T17279 T17278 prep in,described
R4863 T17280 T17281 det this,report
R4864 T17281 T17279 pobj report,in
R4865 T17282 T17256 punct ", ",confirm
R4866 T17283 T17256 aux do,confirm
R4867 T17284 T17285 det an,function
R4868 T17285 T17256 dobj function,confirm
R4869 T17286 T17287 advmod evolutionarily,conserved
R4870 T17287 T17285 amod conserved,function
R4871 T17288 T17285 prep in,function
R4872 T17289 T17290 amod canonical,signaling
R4873 T17290 T17288 pobj signaling,in
R4874 T17291 T17290 compound Wnt,signaling
R4875 T17292 T17256 punct .,confirm
R4876 T17294 T17295 prep In,are
R4877 T17296 T17294 pobj mammals,In
R4878 T17297 T17295 punct ", ",are
R4879 T17298 T17295 advmod however,are
R4880 T17299 T17295 punct ", ",are
R4881 T17300 T17301 det the,effects
R4882 T17301 T17295 nsubj effects,are
R4883 T17302 T17301 amod phenotypic,effects
R4884 T17303 T17301 prep of,effects
R4885 T17304 T17305 compound Pygopus,mutation
R4886 T17305 T17303 pobj mutation,of
R4887 T17306 T17307 advmod much,milder
R4888 T17307 T17295 acomp milder,are
R4889 T17308 T17307 prep than,milder
R4890 T17309 T17308 prep in,than
R4891 T17310 T17309 pobj Drosophila,in
R4892 T17311 T17295 punct .,are
R4893 T17313 T17314 det The,degree
R4894 T17314 T17315 nsubj degree,was
R4895 T17316 T17314 prep of,degree
R4896 T17317 T17316 pobj importance,of
R4897 T17318 T17317 prep of,importance
R4898 T17319 T17320 det the,genes
R4899 T17320 T17318 pobj genes,of
R4900 T17321 T17320 nmod Pyg1,genes
R4901 T17322 T17321 punct /,Pyg1
R4902 T17323 T17321 nummod 2,Pyg1
R4903 T17324 T17314 prep in,degree
R4904 T17325 T17326 compound Wnt,signaling
R4905 T17326 T17324 pobj signaling,in
R4906 T17327 T17328 npadvmod context,dependent
R4907 T17328 T17315 acomp dependent,was
R4908 T17329 T17328 punct -,dependent
R4909 T17330 T17315 punct ", ",was
R4910 T17331 T17315 cc but,was
R4911 T17332 T17333 prep in,remained
R4912 T17333 T17315 conj remained,was
R4913 T17334 T17332 amod general,in
R4914 T17335 T17333 punct ", ",remained
R4915 T17336 T17337 amod mammalian,organogenesis
R4916 T17337 T17333 nsubj organogenesis,remained
R4917 T17338 T17333 acomp intact,remained
R4918 T17339 T17333 prep in,remained
R4919 T17340 T17341 compound Pygopus,mutants
R4920 T17341 T17339 pobj mutants,in
R4921 T17342 T17333 punct .,remained
R4922 T17344 T17345 advmod Perhaps,is
R4923 T17346 T17347 det the,explanation
R4924 T17347 T17345 nsubj explanation,is
R4925 T17348 T17347 amod simplest,explanation
R4926 T17349 T17350 mark that,show
R4927 T17350 T17345 ccomp show,is
R4928 T17351 T17350 prep in,show
R4929 T17352 T17351 pobj mammals,in
R4930 T17353 T17350 punct ", ",show
R4931 T17354 T17355 amod other,genes
R4932 T17355 T17350 nsubj genes,show
R4933 T17356 T17357 amod partial,redundancy
R4934 T17357 T17350 dobj redundancy,show
R4935 T17358 T17357 amod functional,redundancy
R4936 T17359 T17357 prep with,redundancy
R4937 T17360 T17361 det the,genes
R4938 T17361 T17359 pobj genes,with
R4939 T17362 T17361 nummod two,genes
R4940 T17363 T17361 compound Pygopus,genes
R4941 T17364 T17345 punct .,is
R4942 T17366 T17367 det The,complex
R4943 T17367 T17374 nsubj complex,includes
R4944 T17368 T17369 compound β,catenin
R4945 T17369 T17367 compound catenin,complex
R4946 T17370 T17369 punct -,catenin
R4947 T17371 T17372 compound transcription,factor
R4948 T17372 T17367 compound factor,complex
R4949 T17373 T17372 punct -,factor
R4950 T17375 T17376 det a,number
R4951 T17376 T17374 dobj number,includes
R4952 T17377 T17376 amod large,number
R4953 T17378 T17377 cc and,large
R4954 T17379 T17377 conj growing,large
R4955 T17380 T17376 prep of,number
R4956 T17381 T17380 pobj proteins,of
R4957 T17382 T17381 punct ", ",proteins
R4958 T17383 T17384 dep some,share
R4959 T17384 T17381 relcl share,proteins
R4960 T17385 T17383 prep of,some
R4961 T17386 T17385 pobj which,of
R4962 T17387 T17384 aux may,share
R4963 T17388 T17389 det the,functions
R4964 T17389 T17384 dobj functions,share
R4965 T17390 T17391 amod nuclear,localization
R4966 T17391 T17389 nmod localization,functions
R4967 T17392 T17391 cc and,localization
R4968 T17393 T17392 punct /,and
R4969 T17394 T17392 cc or,and
R4970 T17395 T17396 compound transcription,activation
R4971 T17396 T17391 conj activation,localization
R4972 T17397 T17389 prep of,functions
R4973 T17398 T17399 compound Pygo1,Pygo2
R4974 T17399 T17397 pobj Pygo2,of
R4975 T17400 T17399 punct /,Pygo2
R4976 T17401 T17389 prep in,functions
R4977 T17402 T17401 pobj mammals,in
R4978 T17403 T17374 punct .,includes
R4979 T17405 T17406 det The,identities
R4980 T17406 T17407 nsubj identities,remain
R4981 T17408 T17406 cc and,identities
R4982 T17409 T17406 conj roles,identities
R4983 T17410 T17406 prep of,identities
R4984 T17411 T17412 det these,genes
R4985 T17412 T17410 pobj genes,of
R4986 T17413 T17414 npadvmod Pygopus,redundant
R4987 T17414 T17412 amod redundant,genes
R4988 T17415 T17416 aux to,determined
R4989 T17416 T17407 xcomp determined,remain
R4990 T17417 T17416 auxpass be,determined
R4991 T17418 T17407 punct .,remain
R4994 T18190 T18189 prep of,Targeting
R4995 T18191 T18190 pobj Pygo1,of
R4996 T18192 T18191 cc and,Pygo1
R4997 T18193 T18191 conj Pygo2,Pygo1
R4998 T18195 T18196 nmod Pygo1,genes
R4999 T18196 T18199 nsubjpass genes,targeted
R5000 T18197 T18195 cc and,Pygo1
R5001 T18198 T18195 conj Pygo2,Pygo1
R5002 T18200 T18199 auxpass were,targeted
R5003 T18201 T18199 advmod each,targeted
R5004 T18202 T18199 prep by,targeted
R5005 T18203 T18202 pcomp flanking,by
R5006 T18204 T18205 det the,regions
R5007 T18205 T18203 dobj regions,flanking
R5008 T18206 T18205 amod critical,regions
R5009 T18207 T18205 compound coding,regions
R5010 T18208 T18205 prep of,regions
R5011 T18209 T18210 det the,exon
R5012 T18210 T18208 pobj exon,of
R5013 T18211 T18210 amod third,exon
R5014 T18212 T18205 acl containing,regions
R5015 T18213 T18214 det the,motif
R5016 T18214 T18212 dobj motif,containing
R5017 T18215 T18214 compound PHD,motif
R5018 T18216 T18214 prep with,motif
R5019 T18217 T18218 compound LoxP,sequences
R5020 T18218 T18216 pobj sequences,with
R5021 T18219 T18199 punct .,targeted
R5022 T18221 T18222 compound Targeting,constructs
R5023 T18222 T18223 nsubjpass constructs,made
R5024 T18224 T18223 auxpass were,made
R5025 T18225 T18223 advcl using,made
R5026 T18226 T18227 det the,vector
R5027 T18227 T18225 dobj vector,using
R5028 T18228 T18229 compound Flp,Cre
R5029 T18229 T18227 compound Cre,vector
R5030 T18230 T18229 punct /,Cre
R5031 T18231 T18232 advmod previously,described
R5032 T18232 T18227 acl described,vector
R5033 T18233 T18234 punct [,34
R5034 T18234 T18232 parataxis 34,described
R5035 T18235 T18234 punct ],34
R5036 T18236 T18227 punct ", ",vector
R5037 T18237 T18238 dep which,carries
R5038 T18238 T18227 relcl carries,vector
R5039 T18239 T18240 det a,gene
R5040 T18240 T18238 dobj gene,carries
R5041 T18241 T18242 compound neomycin,resistance
R5042 T18242 T18240 compound resistance,gene
R5043 T18243 T18242 punct -,resistance
R5044 T18244 T18240 acl flanked,gene
R5045 T18245 T18244 agent by,flanked
R5046 T18246 T18247 compound FRT,sequences
R5047 T18247 T18245 pobj sequences,by
R5048 T18248 T18227 punct ", ",vector
R5049 T18249 T18227 cc and,vector
R5050 T18250 T18251 nummod three,sites
R5051 T18251 T18227 conj sites,vector
R5052 T18252 T18251 amod unique,sites
R5053 T18253 T18251 compound restriction,sites
R5054 T18254 T18251 prep for,sites
R5055 T18255 T18254 pcomp subcloning,for
R5056 T18256 T18257 det the,blocks
R5057 T18257 T18255 dobj blocks,subcloning
R5058 T18258 T18257 nummod two,blocks
R5059 T18259 T18257 prep of,blocks
R5060 T18260 T18259 pobj homology,of
R5061 T18261 T18255 prep for,subcloning
R5062 T18262 T18263 amod driving,recombination
R5063 T18263 T18261 pobj recombination,for
R5064 T18264 T18251 punct ", ",sites
R5065 T18265 T18251 cc and,sites
R5066 T18266 T18267 det the,region
R5067 T18267 T18251 conj region,sites
R5068 T18268 T18267 amod critical,region
R5069 T18269 T18270 aux to,flanked
R5070 T18270 T18267 advcl flanked,region
R5071 T18271 T18270 auxpass be,flanked
R5072 T18272 T18270 agent by,flanked
R5073 T18273 T18274 compound LoxP,sequences
R5074 T18274 T18272 pobj sequences,by
R5075 T18275 T18223 punct .,made
R5076 T18277 T18278 prep For,made
R5077 T18279 T18280 det each,construct
R5078 T18280 T18277 pobj construct,For
R5079 T18281 T18278 punct ", ",made
R5080 T18282 T18283 det the,segments
R5081 T18283 T18278 nsubjpass segments,made
R5082 T18284 T18283 nummod three,segments
R5083 T18285 T18283 amod genomic,segments
R5084 T18286 T18283 acl required,segments
R5085 T18287 T18286 prep for,required
R5086 T18288 T18287 pobj subcloning,for
R5087 T18289 T18278 auxpass were,made
R5088 T18290 T18278 prep by,made
R5089 T18291 T18290 pobj PCR,by
R5090 T18292 T18291 prep from,PCR
R5091 T18293 T18294 compound RI,DNA
R5092 T18294 T18292 pobj DNA,from
R5093 T18295 T18296 compound ES,cell
R5094 T18296 T18294 compound cell,DNA
R5095 T18297 T18278 punct .,made
R5096 T18299 T18300 det The,constructs
R5097 T18300 T18303 nsubjpass constructs,confirmed
R5098 T18301 T18300 amod resulting,constructs
R5099 T18302 T18300 compound targeting,constructs
R5100 T18304 T18303 auxpass were,confirmed
R5101 T18305 T18303 prep by,confirmed
R5102 T18306 T18305 pobj sequencing,by
R5103 T18307 T18303 punct .,confirmed
R5104 T18309 T18310 prep For,were
R5105 T18311 T18309 pobj Pygo1,For
R5106 T18312 T18310 punct ", ",were
R5107 T18313 T18314 det the,sequences
R5108 T18314 T18310 nsubj sequences,were
R5109 T18315 T18314 amod genomic,sequences
R5110 T18316 T18314 acl used,sequences
R5111 T18317 T18316 prep for,used
R5112 T18318 T18317 pobj PCR,for
R5113 T18319 T18310 punct : ,were
R5114 T18320 T18321 npadvmod 5,forward
R5115 T18321 T18323 amod forward,GTGAAGGAGAGATGGATAAGTATG
R5116 T18322 T18320 punct ',5
R5117 T18323 T18310 attr GTGAAGGAGAGATGGATAAGTATG,were
R5118 T18324 T18323 punct ", ",GTGAAGGAGAGATGGATAAGTATG
R5119 T18325 T18323 punct ;,GTGAAGGAGAGATGGATAAGTATG
R5120 T18326 T18327 npadvmod 5,back
R5121 T18327 T18329 amod back,TAGACCCTAACCACCTACAAG
R5122 T18328 T18326 punct ',5
R5123 T18329 T18323 appos TAGACCCTAACCACCTACAAG,GTGAAGGAGAGATGGATAAGTATG
R5124 T18330 T18329 punct ", ",TAGACCCTAACCACCTACAAG
R5125 T18331 T18323 punct ;,GTGAAGGAGAGATGGATAAGTATG
R5126 T18332 T18333 npadvmod exon,forward
R5127 T18333 T18334 amod forward,GGTTAGGGTCTATGTGCTGG
R5128 T18334 T18323 appos GGTTAGGGTCTATGTGCTGG,GTGAAGGAGAGATGGATAAGTATG
R5129 T18335 T18334 punct ", ",GGTTAGGGTCTATGTGCTGG
R5130 T18336 T18323 punct ;,GTGAAGGAGAGATGGATAAGTATG
R5131 T18337 T18338 npadvmod exon,back
R5132 T18338 T18339 amod back,TCACCAAATCTCTGTTCTACAC
R5133 T18339 T18323 appos TCACCAAATCTCTGTTCTACAC,GTGAAGGAGAGATGGATAAGTATG
R5134 T18340 T18339 punct ", ",TCACCAAATCTCTGTTCTACAC
R5135 T18341 T18323 punct ;,GTGAAGGAGAGATGGATAAGTATG
R5136 T18342 T18343 npadvmod 3,forward
R5137 T18343 T18345 amod forward,TGTGTAGAACAGAGATTTGGTG
R5138 T18344 T18342 punct ',3
R5139 T18345 T18323 appos TGTGTAGAACAGAGATTTGGTG,GTGAAGGAGAGATGGATAAGTATG
R5140 T18346 T18345 punct ", ",TGTGTAGAACAGAGATTTGGTG
R5141 T18347 T18323 punct ;,GTGAAGGAGAGATGGATAAGTATG
R5142 T18348 T18349 npadvmod 3,back
R5143 T18349 T18351 amod back,CAGTGAAGAAAGAGGGTCAG
R5144 T18350 T18348 punct ',3
R5145 T18351 T18323 appos CAGTGAAGAAAGAGGGTCAG,GTGAAGGAGAGATGGATAAGTATG
R5146 T18352 T18351 punct ", ",CAGTGAAGAAAGAGGGTCAG
R5147 T18353 T18310 punct .,were
R5148 T18355 T18356 prep For,were
R5149 T18357 T18355 pobj Pygo2,For
R5150 T18358 T18356 punct ", ",were
R5151 T18359 T18360 det the,sequences
R5152 T18360 T18356 nsubj sequences,were
R5153 T18361 T18360 amod genomic,sequences
R5154 T18362 T18360 acl used,sequences
R5155 T18363 T18362 prep for,used
R5156 T18364 T18363 pobj PCR,for
R5157 T18365 T18356 punct : ,were
R5158 T18366 T18356 attr GCCTGGGTTGCTTGTCTTCTG,were
R5159 T18367 T18366 cc and,GCCTGGGTTGCTTGTCTTCTG
R5160 T18368 T18366 conj CCACCTTACTTGTGTGTGAGGATACATAC,GCCTGGGTTGCTTGTCTTCTG
R5161 T18369 T18366 punct ", ",GCCTGGGTTGCTTGTCTTCTG
R5162 T18370 T18366 conj CCAAGTCCCAGCATCTCTTAC,GCCTGGGTTGCTTGTCTTCTG
R5163 T18371 T18370 cc and,CCAAGTCCCAGCATCTCTTAC
R5164 T18372 T18370 conj CCAGTCATACCAGCAACAAG,CCAAGTCCCAGCATCTCTTAC
R5165 T18373 T18370 punct ", ",CCAAGTCCCAGCATCTCTTAC
R5166 T18374 T18370 cc and,CCAAGTCCCAGCATCTCTTAC
R5167 T18375 T18376 compound exon,sequences
R5168 T18376 T18377 compound sequences,TGGGTGCTGGGAACAGAAC
R5169 T18377 T18370 conj TGGGTGCTGGGAACAGAAC,CCAAGTCCCAGCATCTCTTAC
R5170 T18378 T18377 cc and,TGGGTGCTGGGAACAGAAC
R5171 T18379 T18377 conj CAACAACAACAGAAGACAAGC,TGGGTGCTGGGAACAGAAC
R5172 T18380 T18356 punct .,were
R5173 T18382 T18383 amod Linearized,constructs
R5174 T18383 T18384 nsubjpass constructs,electroporated
R5175 T18385 T18384 auxpass were,electroporated
R5176 T18386 T18384 prep into,electroporated
R5177 T18387 T18388 compound RI,cells
R5178 T18388 T18386 pobj cells,into
R5179 T18389 T18388 compound ES,cells
R5180 T18390 T18384 punct ", ",electroporated
R5181 T18391 T18384 cc and,electroporated
R5182 T18392 T18393 amod resulting,cells
R5183 T18393 T18396 nsubj cells,used
R5184 T18394 T18393 amod targeted,cells
R5185 T18395 T18393 compound ES,cells
R5186 T18396 T18384 conj used,electroporated
R5187 T18397 T18396 prep for,used
R5188 T18398 T18399 compound C57,Bl6
R5189 T18399 T18401 compound Bl6,injections
R5190 T18400 T18399 punct /,Bl6
R5191 T18401 T18397 pobj injections,for
R5192 T18402 T18401 compound blastocyst,injections
R5193 T18403 T18396 prep according,used
R5194 T18404 T18403 prep to,according
R5195 T18405 T18406 amod standard,protocols
R5196 T18406 T18404 pobj protocols,to
R5197 T18407 T18396 punct .,used
R5198 T18409 T18410 amod Resulting,chimeras
R5199 T18410 T18411 nsubjpass chimeras,mated
R5200 T18412 T18411 auxpass were,mated
R5201 T18413 T18411 prep with,mated
R5202 T18414 T18415 compound Swiss,Black
R5203 T18415 T18416 compound Black,mice
R5204 T18416 T18413 pobj mice,with
R5205 T18417 T18411 punct ", ",mated
R5206 T18418 T18411 cc and,mated
R5207 T18419 T18420 det the,stocks
R5208 T18420 T18422 nsubj stocks,maintained
R5209 T18421 T18420 amod targeted,stocks
R5210 T18422 T18411 conj maintained,mated
R5211 T18423 T18422 prep on,maintained
R5212 T18424 T18425 det a,background
R5213 T18425 T18423 pobj background,on
R5214 T18426 T18425 amod mixed,background
R5215 T18427 T18428 nummod 129,Black
R5216 T18428 T18425 compound Black,background
R5217 T18429 T18428 punct /,Black
R5218 T18430 T18428 compound Swiss,Black
R5219 T18431 T18422 punct .,maintained
R5220 T18433 T18434 nmod Germline,alleles
R5221 T18434 T18436 nsubjpass alleles,generated
R5222 T18435 T18434 amod null,alleles
R5223 T18437 T18434 prep of,alleles
R5224 T18438 T18439 preconj both,Pygo1
R5225 T18439 T18437 pobj Pygo1,of
R5226 T18440 T18439 cc and,Pygo1
R5227 T18441 T18439 conj Pygo2,Pygo1
R5228 T18442 T18436 auxpass were,generated
R5229 T18443 T18436 prep by,generated
R5230 T18444 T18443 pcomp mating,by
R5231 T18445 T18446 amod heterozygous,mice
R5232 T18446 T18444 dobj mice,mating
R5233 T18447 T18446 amod floxed,mice
R5234 T18448 T18444 prep with,mating
R5235 T18449 T18450 det the,mice
R5236 T18450 T18448 pobj mice,with
R5237 T18451 T18452 compound CMV,Cre
R5238 T18452 T18450 compound Cre,mice
R5239 T18453 T18452 punct -,Cre
R5240 T18454 T18455 punct [,15
R5241 T18455 T18436 parataxis 15,generated
R5242 T18456 T18455 punct ],15
R5243 T18457 T18436 punct .,generated
R5244 T18459 T18460 det The,sequences
R5245 T18460 T18461 nsubj sequences,were
R5246 T18462 T18460 prep of,sequences
R5247 T18463 T18464 det the,primers
R5248 T18464 T18462 pobj primers,of
R5249 T18465 T18464 acl used,primers
R5250 T18466 T18465 prep for,used
R5251 T18467 T18468 amod genotyping,PCR
R5252 T18468 T18466 pobj PCR,for
R5253 T18469 T18461 punct : ,were
R5254 T18470 T18471 npadvmod Pygo2,null
R5255 T18471 T18472 amod null,allele
R5256 T18472 T18461 attr allele,were
R5257 T18473 T18472 punct ", ",allele
R5258 T18474 T18475 nmod forward,CCTGGATTCTTGTTGCTGGTATG
R5259 T18475 T18472 appos CCTGGATTCTTGTTGCTGGTATG,allele
R5260 T18476 T18474 punct (,forward
R5261 T18477 T18474 appos F,forward
R5262 T18478 T18475 punct ),CCTGGATTCTTGTTGCTGGTATG
R5263 T18479 T18475 punct ;,CCTGGATTCTTGTTGCTGGTATG
R5264 T18480 T18481 nmod reverse,AAGGTATTTGGTGCTCCGAGGG
R5265 T18481 T18475 appos AAGGTATTTGGTGCTCCGAGGG,CCTGGATTCTTGTTGCTGGTATG
R5266 T18482 T18480 punct (,reverse
R5267 T18483 T18480 appos R,reverse
R5268 T18484 T18481 punct ),AAGGTATTTGGTGCTCCGAGGG
R5269 T18485 T18472 punct ;,allele
R5270 T18486 T18487 nmod Pygo2,allele
R5271 T18487 T18472 appos allele,allele
R5272 T18488 T18487 nmod WT,allele
R5273 T18489 T18488 cc or,WT
R5274 T18490 T18488 conj floxed,WT
R5275 T18491 T18487 punct ", ",allele
R5276 T18492 T18493 compound F,TGTCTTGATGACAGCGTTTAGCC
R5277 T18493 T18487 appos TGTCTTGATGACAGCGTTTAGCC,allele
R5278 T18494 T18493 punct ", ",TGTCTTGATGACAGCGTTTAGCC
R5279 T18495 T18496 compound R,AGATTCAGTAAGCTGAGCCTGGTG
R5280 T18496 T18493 appos AGATTCAGTAAGCTGAGCCTGGTG,TGTCTTGATGACAGCGTTTAGCC
R5281 T18497 T18472 punct ;,allele
R5282 T18498 T18499 npadvmod Pygo1,null
R5283 T18499 T18500 amod null,allele
R5284 T18500 T18472 appos allele,allele
R5285 T18501 T18500 punct ", ",allele
R5286 T18502 T18503 compound F,AGTTTGAAATAGCGACGAGTTTGAG
R5287 T18503 T18500 appos AGTTTGAAATAGCGACGAGTTTGAG,allele
R5288 T18504 T18503 punct ", ",AGTTTGAAATAGCGACGAGTTTGAG
R5289 T18505 T18506 nmod R,5
R5290 T18506 T18507 nummod 5,CACTTCTGCCCCTCTCTTTGC
R5291 T18507 T18503 appos CACTTCTGCCCCTCTCTTTGC,AGTTTGAAATAGCGACGAGTTTGAG
R5292 T18508 T18506 punct ',5
R5293 T18509 T18507 punct -,CACTTCTGCCCCTCTCTTTGC
R5294 T18510 T18472 punct ;,allele
R5295 T18511 T18512 nmod Pygo1,allele
R5296 T18512 T18472 appos allele,allele
R5297 T18513 T18512 nmod WT,allele
R5298 T18514 T18513 cc or,WT
R5299 T18515 T18513 conj floxed,WT
R5300 T18516 T18512 punct ", ",allele
R5301 T18517 T18518 compound F,AAGCGTGCCTCATCTCCATCCCTAAG
R5302 T18518 T18512 appos AAGCGTGCCTCATCTCCATCCCTAAG,allele
R5303 T18519 T18518 punct ", ",AAGCGTGCCTCATCTCCATCCCTAAG
R5304 T18520 T18521 compound R,GCCCTCCCCGACGTTTATATTG
R5305 T18521 T18518 appos GCCCTCCCCGACGTTTATATTG,AAGCGTGCCTCATCTCCATCCCTAAG
R5306 T18522 T18461 punct .,were
R5307 T18524 T18525 det The,noon
R5308 T18525 T18526 nsubjpass noon,designated
R5309 T18527 T18525 prep of,noon
R5310 T18528 T18529 det the,day
R5311 T18529 T18527 pobj day,of
R5312 T18530 T18531 prep that,observed
R5313 T18531 T18529 relcl observed,day
R5314 T18532 T18533 amod vaginal,plugs
R5315 T18533 T18531 nsubjpass plugs,observed
R5316 T18534 T18531 auxpass were,observed
R5317 T18535 T18526 auxpass was,designated
R5318 T18536 T18526 oprd E0.5,designated
R5319 T18537 T18526 punct .,designated
R5320 T19104 T19105 amod Confocal,microscopy
R5321 T19107 T19108 nsubj Kidneys,dissected
R5322 T19109 T19108 aux were,dissected
R5323 T19110 T19108 punct ", ",dissected
R5324 T19111 T19108 conj fixed,dissected
R5325 T19112 T19111 prep in,fixed
R5326 T19113 T19112 pobj paraformaldehyde,in
R5327 T19114 T19111 punct ", ",fixed
R5328 T19115 T19111 conj treated,fixed
R5329 T19116 T19115 prep with,treated
R5330 T19117 T19116 pobj methanol,with
R5331 T19118 T19115 punct ", ",treated
R5332 T19119 T19115 cc and,treated
R5333 T19120 T19115 conj washed,treated
R5334 T19121 T19120 prep with,washed
R5335 T19122 T19121 pobj PBS,with
R5336 T19123 T19122 acl containing,PBS
R5337 T19124 T19123 dobj Tween,containing
R5338 T19125 T19124 punct -,Tween
R5339 T19126 T19124 nummod 20,Tween
R5340 T19127 T19122 punct (,PBS
R5341 T19128 T19129 compound PBS,T
R5342 T19129 T19122 appos T,PBS
R5343 T19130 T19129 punct -,T
R5344 T19131 T19108 punct ),dissected
R5345 T19132 T19133 amod prior,to
R5346 T19133 T19108 prep to,dissected
R5347 T19134 T19133 pobj treatment,to
R5348 T19135 T19134 prep with,treatment
R5349 T19136 T19135 pobj lectins,with
R5350 T19137 T19136 cc and,lectins
R5351 T19138 T19136 conj antibodies,lectins
R5352 T19139 T19108 punct .,dissected
R5353 T19141 T19142 compound PBS,T
R5354 T19142 T19144 nsubjpass T,used
R5355 T19143 T19142 punct -,T
R5356 T19145 T19144 auxpass was,used
R5357 T19146 T19144 prep for,used
R5358 T19147 T19146 pobj incubations,for
R5359 T19148 T19147 prep of,incubations
R5360 T19149 T19150 det the,tissues
R5361 T19150 T19148 pobj tissues,of
R5362 T19151 T19147 prep with,incubations
R5363 T19152 T19153 npadvmod fluoroscein,conjugated
R5364 T19153 T19155 amod conjugated,aggutinin
R5365 T19154 T19153 punct -,conjugated
R5366 T19155 T19151 pobj aggutinin,with
R5367 T19156 T19155 compound Dilichos,aggutinin
R5368 T19157 T19155 compound biflorus,aggutinin
R5369 T19158 T19155 punct (,aggutinin
R5370 T19159 T19155 appos DBA,aggutinin
R5371 T19160 T19155 punct ", ",aggutinin
R5372 T19161 T19155 parataxis Vector,aggutinin
R5373 T19162 T19161 punct ;,Vector
R5374 T19163 T19161 npadvmod Burlingame,Vector
R5375 T19164 T19161 punct ", ",Vector
R5376 T19165 T19161 npadvmod USA,Vector
R5377 T19166 T19161 punct ),Vector
R5378 T19167 T19144 punct ", ",used
R5379 T19168 T19144 cc and,used
R5380 T19169 T19170 compound PBS,T
R5381 T19170 T19172 nsubjpass T,used
R5382 T19171 T19170 punct -,T
R5383 T19172 T19144 conj used,used
R5384 T19173 T19170 cc plus,T
R5385 T19174 T19175 nummod 2,%
R5386 T19175 T19176 compound %,serum
R5387 T19176 T19170 conj serum,T
R5388 T19177 T19176 compound goat,serum
R5389 T19178 T19172 auxpass was,used
R5390 T19179 T19172 prep for,used
R5391 T19180 T19179 pobj incubations,for
R5392 T19181 T19180 prep with,incubations
R5393 T19182 T19183 det the,antibodies
R5394 T19183 T19181 pobj antibodies,with
R5395 T19184 T19172 punct .,used
R5396 T19186 T19187 det The,antibodies
R5397 T19187 T19189 nsubj antibodies,were
R5398 T19188 T19187 amod primary,antibodies
R5399 T19190 T19189 attr anti-WT1,were
R5400 T19191 T19192 punct (,Biotechnology
R5401 T19192 T19190 parataxis Biotechnology,anti-WT1
R5402 T19193 T19192 dep c,Biotechnology
R5403 T19194 T19193 punct -,c
R5404 T19195 T19193 nummod 19,c
R5405 T19196 T19192 punct ;,Biotechnology
R5406 T19197 T19198 compound Santa,Cruz
R5407 T19198 T19192 compound Cruz,Biotechnology
R5408 T19199 T19192 punct ", ",Biotechnology
R5409 T19200 T19201 compound Santa,Cruz
R5410 T19201 T19192 npadvmod Cruz,Biotechnology
R5411 T19202 T19192 punct ", ",Biotechnology
R5412 T19203 T19192 npadvmod CA,Biotechnology
R5413 T19204 T19192 punct ", ",Biotechnology
R5414 T19205 T19192 npadvmod USA,Biotechnology
R5415 T19206 T19192 punct ),Biotechnology
R5416 T19207 T19190 punct ", ",anti-WT1
R5417 T19208 T19190 conj anti-uvomorulin,anti-WT1
R5418 T19209 T19208 punct (,anti-uvomorulin
R5419 T19210 T19211 compound e,cadherin
R5420 T19211 T19208 appos cadherin,anti-uvomorulin
R5421 T19212 T19211 punct -,cadherin
R5422 T19213 T19208 punct ", ",anti-uvomorulin
R5423 T19214 T19208 appos Cdh1,anti-uvomorulin
R5424 T19215 T19216 punct ", ",Aldrich
R5425 T19216 T19208 parataxis Aldrich,anti-uvomorulin
R5426 T19217 T19216 compound Sigma,Aldrich
R5427 T19218 T19216 punct -,Aldrich
R5428 T19219 T19220 compound St.,Louis
R5429 T19220 T19216 npadvmod Louis,Aldrich
R5430 T19221 T19220 punct ", ",Louis
R5431 T19222 T19216 npadvmod MO,Aldrich
R5432 T19223 T19216 punct ", ",Aldrich
R5433 T19224 T19216 npadvmod USA,Aldrich
R5434 T19225 T19216 punct ),Aldrich
R5435 T19226 T19208 punct ", ",anti-uvomorulin
R5436 T19227 T19208 cc and,anti-uvomorulin
R5437 T19228 T19208 conj anti-Cited1,anti-uvomorulin
R5438 T19229 T19230 punct (,Corporation
R5439 T19230 T19228 parataxis Corporation,anti-Cited1
R5440 T19231 T19230 compound Neomarkers,Corporation
R5441 T19232 T19230 punct -,Corporation
R5442 T19233 T19230 compound Lab,Corporation
R5443 T19234 T19230 compound Vision,Corporation
R5444 T19235 T19230 punct ", ",Corporation
R5445 T19236 T19230 npadvmod Fremont,Corporation
R5446 T19237 T19230 punct ", ",Corporation
R5447 T19238 T19230 npadvmod CA,Corporation
R5448 T19239 T19230 punct ", ",Corporation
R5449 T19240 T19230 npadvmod USA,Corporation
R5450 T19241 T19230 punct ),Corporation
R5451 T19242 T19189 punct .,were
R5452 T19244 T19245 det The,antibodies
R5453 T19245 T19247 nsubj antibodies,were
R5454 T19246 T19245 amod secondary,antibodies
R5455 T19248 T19249 npadvmod Alexa,conjugated
R5456 T19249 T19252 amod conjugated,anti-rabbit
R5457 T19250 T19248 nummod 555,Alexa
R5458 T19251 T19249 punct -,conjugated
R5459 T19252 T19253 nmod anti-rabbit,antibodies
R5460 T19253 T19247 attr antibodies,were
R5461 T19254 T19252 cc and,anti-rabbit
R5462 T19255 T19256 npadvmod Alexa,conjugated
R5463 T19256 T19259 amod conjugated,anti-rat
R5464 T19257 T19255 nummod 633,Alexa
R5465 T19258 T19256 punct -,conjugated
R5466 T19259 T19252 conj anti-rat,anti-rabbit
R5467 T19260 T19261 punct (,Probes
R5468 T19261 T19253 parataxis Probes,antibodies
R5469 T19262 T19261 compound Molecular,Probes
R5470 T19263 T19261 punct ", ",Probes
R5471 T19264 T19261 npadvmod Eugene,Probes
R5472 T19265 T19261 punct ", ",Probes
R5473 T19266 T19261 npadvmod OR,Probes
R5474 T19267 T19261 punct ", ",Probes
R5475 T19268 T19261 npadvmod USA,Probes
R5476 T19269 T19261 punct ),Probes
R5477 T19270 T19247 punct .,were
R5478 T19272 T19273 det The,tissues
R5479 T19273 T19274 nsubjpass tissues,imaged
R5480 T19275 T19274 auxpass were,imaged
R5481 T19276 T19274 prep with,imaged
R5482 T19277 T19278 det a,microscope
R5483 T19278 T19276 pobj microscope,with
R5484 T19279 T19278 compound laser,microscope
R5485 T19280 T19278 compound scanning,microscope
R5486 T19281 T19282 punct (,Zeiss
R5487 T19282 T19278 parataxis Zeiss,microscope
R5488 T19283 T19282 compound Carl,Zeiss
R5489 T19284 T19282 punct ", ",Zeiss
R5490 T19285 T19282 npadvmod Thornwood,Zeiss
R5491 T19286 T19282 punct ", ",Zeiss
R5492 T19287 T19288 compound New,York
R5493 T19288 T19282 npadvmod York,Zeiss
R5494 T19289 T19282 punct ", ",Zeiss
R5495 T19290 T19282 npadvmod USA,Zeiss
R5496 T19291 T19282 punct ),Zeiss
R5497 T19292 T19278 acl equipped,microscope
R5498 T19293 T19292 prep with,equipped
R5499 T19294 T19295 nummod an,argon
R5500 T19295 T19293 pobj argon,with
R5501 T19296 T19297 punct (,nm
R5502 T19297 T19295 parataxis nm,argon
R5503 T19298 T19297 nummod 488,nm
R5504 T19299 T19297 punct ),nm
R5505 T19300 T19295 cc and,argon
R5506 T19301 T19302 nummod two,HeNe
R5507 T19302 T19303 compound HeNe,lasers
R5508 T19303 T19295 conj lasers,argon
R5509 T19304 T19305 punct (,nm
R5510 T19305 T19303 parataxis nm,lasers
R5511 T19306 T19305 nummod 543,nm
R5512 T19307 T19305 cc and,nm
R5513 T19308 T19309 nummod 633,nm
R5514 T19309 T19305 conj nm,nm
R5515 T19310 T19305 punct ),nm
R5516 T19311 T19274 punct .,imaged
R5517 T19313 T19314 amod Optical,sections
R5518 T19314 T19315 nsubjpass sections,obtained
R5519 T19316 T19317 advmod approximately,2
R5520 T19317 T19318 nummod 2,μm
R5521 T19318 T19319 compound μm,thick
R5522 T19319 T19314 amod thick,sections
R5523 T19320 T19315 auxpass were,obtained
R5524 T19321 T19322 det every,μm
R5525 T19322 T19315 npadvmod μm,obtained
R5526 T19323 T19322 nummod 5,μm
R5527 T19324 T19315 prep to,obtained
R5528 T19325 T19326 det a,depth
R5529 T19326 T19324 pobj depth,to
R5530 T19327 T19326 prep of,depth
R5531 T19328 T19329 advmod at,65
R5532 T19329 T19331 nummod 65,μm
R5533 T19330 T19329 advmod least,65
R5534 T19331 T19327 pobj μm,of
R5535 T19332 T19315 punct .,obtained
R5536 T19334 T19335 det The,sections
R5537 T19335 T19336 nsubj sections,began
R5538 T19337 T19336 prep at,began
R5539 T19338 T19339 det the,surface
R5540 T19339 T19337 pobj surface,at
R5541 T19340 T19339 prep of,surface
R5542 T19341 T19342 det the,kidney
R5543 T19342 T19340 pobj kidney,of
R5544 T19343 T19336 cc and,began
R5545 T19344 T19336 conj were,began
R5546 T19345 T19344 prep on,were
R5547 T19346 T19347 det a,plane
R5548 T19347 T19345 pobj plane,on
R5549 T19348 T19347 amod tangential,plane
R5550 T19349 T19348 prep to,tangential
R5551 T19350 T19349 pobj it,to
R5552 T19351 T19336 punct .,began
R5553 T19353 T19354 nummod Two,series
R5554 T19354 T19358 nsubjpass series,obtained
R5555 T19355 T19356 compound Z,stack
R5556 T19356 T19354 compound stack,series
R5557 T19357 T19356 punct -,stack
R5558 T19359 T19358 auxpass were,obtained
R5559 T19360 T19358 punct ", ",obtained
R5560 T19361 T19358 dobj one,obtained
R5561 T19362 T19361 prep from,one
R5562 T19363 T19362 pobj each,from
R5563 T19364 T19363 prep of,each
R5564 T19365 T19366 det the,kidneys
R5565 T19366 T19364 pobj kidneys,of
R5566 T19367 T19366 nummod two,kidneys
R5567 T19368 T19366 prep of,kidneys
R5568 T19369 T19370 det each,embryo
R5569 T19370 T19368 pobj embryo,of
R5570 T19371 T19358 punct .,obtained
R5571 T19373 T19374 amod Ureteric,bud
R5572 T19374 T19375 compound bud,tips
R5573 T19375 T19376 nsubjpass tips,counted
R5574 T19377 T19375 acl identified,tips
R5575 T19378 T19377 prep by,identified
R5576 T19379 T19380 compound section,tracing
R5577 T19380 T19378 pobj tracing,by
R5578 T19381 T19376 auxpass were,counted
R5579 T19382 T19376 prep within,counted
R5580 T19383 T19384 det a,area
R5581 T19384 T19382 pobj area,within
R5582 T19385 T19384 amod defined,area
R5583 T19386 T19384 prep of,area
R5584 T19387 T19388 det the,image
R5585 T19388 T19386 pobj image,of
R5586 T19389 T19388 amod confocal,image
R5587 T19390 T19376 punct .,counted
R5588 T19486 T19487 advmod In,situ
R5589 T19487 T19488 amod situ,hybridization
R5590 T19490 T19491 amod Whole,mount
R5591 T19491 T19493 nmod mount,hybridization
R5592 T19492 T19491 punct -,mount
R5593 T19493 T19496 nsubjpass hybridization,performed
R5594 T19494 T19495 advmod in,situ
R5595 T19495 T19493 amod situ,hybridization
R5596 T19497 T19496 auxpass was,performed
R5597 T19498 T19499 mark as,described
R5598 T19499 T19496 advcl described,performed
R5599 T19500 T19499 advmod previously,described
R5600 T19501 T19502 punct [,35
R5601 T19502 T19499 parataxis 35,described
R5602 T19503 T19502 punct ],35
R5603 T19504 T19496 punct .,performed
R5604 T19506 T19507 nsubjpass Riboprobes,described
R5605 T19508 T19506 prep to,Riboprobes
R5606 T19509 T19508 pobj Wnt11,to
R5607 T19510 T19509 cc and,Wnt11
R5608 T19511 T19509 conj Wnt7b,Wnt11
R5609 T19512 T19507 auxpass were,described
R5610 T19513 T19507 advmod previously,described
R5611 T19514 T19515 punct [,35
R5612 T19515 T19507 parataxis 35,described
R5613 T19516 T19515 punct ],35
R5614 T19517 T19507 punct .,described
R5615 T19519 T19520 det The,riboprobe
R5616 T19520 T19522 nsubjpass riboprobe,provided
R5617 T19521 T19520 compound Wnt9b,riboprobe
R5618 T19523 T19522 auxpass was,provided
R5619 T19524 T19522 agent by,provided
R5620 T19525 T19526 compound T.,Carroll
R5621 T19526 T19524 pobj Carroll,by
R5622 T19527 T19528 punct [,2
R5623 T19528 T19522 parataxis 2,provided
R5624 T19529 T19528 punct ],2
R5625 T19530 T19522 punct .,provided
R5626 T20069 T20070 nmod Pygo1,antibody
R5627 T20070 T20073 compound antibody,production
R5628 T20071 T20069 cc and,Pygo1
R5629 T20072 T20069 conj Pygo2,Pygo1
R5630 T20075 T20076 aux To,generate
R5631 T20076 T20077 advcl generate,subcloned
R5632 T20078 T20079 amod anti-human,Pygo2
R5633 T20079 T20080 nmod Pygo2,antibodies
R5634 T20080 T20076 dobj antibodies,generate
R5635 T20081 T20079 punct (,Pygo2
R5636 T20082 T20079 appos anti-hPygo2,Pygo2
R5637 T20083 T20079 punct ),Pygo2
R5638 T20084 T20079 cc and,Pygo2
R5639 T20085 T20086 amod anti-mouse,Pygo1
R5640 T20086 T20079 conj Pygo1,Pygo2
R5641 T20087 T20086 punct (,Pygo1
R5642 T20088 T20086 appos anti-mPygo1,Pygo1
R5643 T20089 T20080 punct ),antibodies
R5644 T20090 T20080 amod polyclonal,antibodies
R5645 T20091 T20077 punct ", ",subcloned
R5646 T20092 T20077 nsubj we,subcloned
R5647 T20093 T20077 dobj cDNA,subcloned
R5648 T20094 T20077 prep by,subcloned
R5649 T20095 T20094 pobj PCR,by
R5650 T20096 T20095 acl corresponding,PCR
R5651 T20097 T20096 prep to,corresponding
R5652 T20098 T20099 nmod amino,acid
R5653 T20099 T20101 nmod acid,80
R5654 T20100 T20099 punct -,acid
R5655 T20101 T20097 pobj 80,to
R5656 T20102 T20101 nmod residues,80
R5657 T20103 T20104 punct –,327
R5658 T20104 T20101 prep 327,80
R5659 T20105 T20101 prep of,80
R5660 T20106 T20107 amod human,Pygo
R5661 T20107 T20105 pobj Pygo,of
R5662 T20108 T20107 nummod 2,Pygo
R5663 T20109 T20101 cc or,80
R5664 T20110 T20111 nmod amino,acid
R5665 T20111 T20113 nmod acid,76
R5666 T20112 T20111 punct -,acid
R5667 T20113 T20101 conj 76,80
R5668 T20114 T20113 nmod residues,76
R5669 T20115 T20116 punct –,263
R5670 T20116 T20113 prep 263,76
R5671 T20117 T20113 prep of,76
R5672 T20118 T20119 compound mouse,Pygo1
R5673 T20119 T20117 pobj Pygo1,of
R5674 T20120 T20077 prep into,subcloned
R5675 T20121 T20120 pobj pGEX4T1,into
R5676 T20122 T20123 punct (,Health
R5677 T20123 T20121 parataxis Health,pGEX4T1
R5678 T20124 T20123 compound Amersham,Health
R5679 T20125 T20123 punct ", ",Health
R5680 T20126 T20123 npadvmod Piscataway,Health
R5681 T20127 T20123 punct ", ",Health
R5682 T20128 T20123 npadvmod NJ,Health
R5683 T20129 T20123 punct ", ",Health
R5684 T20130 T20123 npadvmod USA,Health
R5685 T20131 T20123 punct ),Health
R5686 T20132 T20077 punct .,subcloned
R5687 T20134 T20135 det The,fragments
R5688 T20135 T20137 nsubj fragments,lack
R5689 T20136 T20135 compound PCR,fragments
R5690 T20138 T20135 prep of,fragments
R5691 T20139 T20138 pobj hPygo,of
R5692 T20140 T20139 nummod 2,hPygo
R5693 T20141 T20139 cc and,hPygo
R5694 T20142 T20139 conj mPygo,hPygo
R5695 T20143 T20142 nummod 1,mPygo
R5696 T20144 T20145 preconj both,NHD
R5697 T20145 T20146 npadvmod NHD,conserved
R5698 T20146 T20149 amod conserved,regions
R5699 T20147 T20145 cc and,NHD
R5700 T20148 T20145 conj PHD,NHD
R5701 T20149 T20137 dobj regions,lack
R5702 T20150 T20149 prep of,regions
R5703 T20151 T20150 pobj hPygo2,of
R5704 T20152 T20151 cc and,hPygo2
R5705 T20153 T20151 conj mPygo1,hPygo2
R5706 T20154 T20137 punct .,lack
R5707 T20156 T20157 nmod GST,hPygo2
R5708 T20157 T20159 nmod hPygo2,proteins
R5709 T20158 T20157 punct -,hPygo2
R5710 T20159 T20164 nsubjpass proteins,expressed
R5711 T20160 T20157 cc and,hPygo2
R5712 T20161 T20162 compound GST,mPygo1
R5713 T20162 T20157 conj mPygo1,hPygo2
R5714 T20163 T20162 punct -,mPygo1
R5715 T20165 T20164 auxpass were,expressed
R5716 T20166 T20164 prep in,expressed
R5717 T20167 T20166 pobj bacteria,in
R5718 T20168 T20164 punct ", ",expressed
R5719 T20169 T20164 conj purified,expressed
R5720 T20170 T20169 punct ", ",purified
R5721 T20171 T20169 cc and,purified
R5722 T20172 T20169 conj injected,purified
R5723 T20173 T20172 prep into,injected
R5724 T20174 T20173 pobj rabbits,into
R5725 T20175 T20172 prep for,injected
R5726 T20176 T20177 compound antibody,production
R5727 T20177 T20175 pobj production,for
R5728 T20178 T20172 agent by,injected
R5729 T20179 T20178 punct (,by
R5730 T20180 T20181 compound Proteintech,Inc.
R5731 T20181 T20178 pobj Inc.,by
R5732 T20182 T20181 compound Group,Inc.
R5733 T20183 T20181 punct ", ",Inc.
R5734 T20184 T20181 npadvmod Chicago,Inc.
R5735 T20185 T20181 punct ", ",Inc.
R5736 T20186 T20181 npadvmod IL,Inc.
R5737 T20187 T20181 punct ", ",Inc.
R5738 T20188 T20181 npadvmod USA,Inc.
R5739 T20189 T20164 punct ),expressed
R5740 T20190 T20164 punct .,expressed
R5741 T20192 T20193 det The,antisera
R5742 T20193 T20195 nsubjpass antisera,allowed
R5743 T20194 T20193 compound rabbit,antisera
R5744 T20196 T20193 prep of,antisera
R5745 T20197 T20196 pobj anti-mPygo1,of
R5746 T20198 T20197 cc and,anti-mPygo1
R5747 T20199 T20197 conj anti-hPygo2,anti-mPygo1
R5748 T20200 T20195 auxpass were,allowed
R5749 T20201 T20195 advmod initially,allowed
R5750 T20202 T20203 aux to,bind
R5751 T20203 T20195 xcomp bind,allowed
R5752 T20204 T20203 prep to,bind
R5753 T20205 T20206 det the,matrix
R5754 T20206 T20204 pobj matrix,to
R5755 T20207 T20206 compound GST,matrix
R5756 T20208 T20206 compound affinity,matrix
R5757 T20209 T20210 aux to,remove
R5758 T20210 T20203 advcl remove,bind
R5759 T20211 T20212 det any,antibodies
R5760 T20212 T20210 dobj antibodies,remove
R5761 T20213 T20212 prep against,antibodies
R5762 T20214 T20213 pobj GST,against
R5763 T20215 T20195 punct .,allowed
R5764 T20217 T20218 det The,antisera
R5765 T20218 T20222 nsubjpass antisera,separated
R5766 T20219 T20218 amod anti-hPygo2,antisera
R5767 T20220 T20219 cc and,anti-hPygo2
R5768 T20221 T20219 conj anti-mPygo1,anti-hPygo2
R5769 T20223 T20222 auxpass were,separated
R5770 T20224 T20222 advmod then,separated
R5771 T20225 T20222 prep from,separated
R5772 T20226 T20227 det the,matrix
R5773 T20227 T20225 pobj matrix,from
R5774 T20228 T20227 compound GST,matrix
R5775 T20229 T20227 compound affinity,matrix
R5776 T20230 T20222 cc and,separated
R5777 T20231 T20222 conj allowed,separated
R5778 T20232 T20233 aux to,bind
R5779 T20233 T20231 xcomp bind,allowed
R5780 T20234 T20233 prep to,bind
R5781 T20235 T20236 det the,columns
R5782 T20236 T20234 pobj columns,to
R5783 T20237 T20238 nmod GST,hPygo2
R5784 T20238 T20236 nmod hPygo2,columns
R5785 T20239 T20238 punct -,hPygo2
R5786 T20240 T20238 cc or,hPygo2
R5787 T20241 T20242 compound GST,mPygo1
R5788 T20242 T20238 conj mPygo1,hPygo2
R5789 T20243 T20242 punct -,mPygo1
R5790 T20244 T20236 compound affinity,columns
R5791 T20245 T20233 punct ", ",bind
R5792 T20246 T20233 advmod respectively,bind
R5793 T20247 T20222 punct .,separated
R5794 T20249 T20250 det The,antibodes
R5795 T20250 T20252 nsubjpass antibodes,eluted
R5796 T20251 T20250 amod bound,antibodes
R5797 T20253 T20252 auxpass were,eluted
R5798 T20254 T20252 prep with,eluted
R5799 T20255 T20256 compound elution,buffer
R5800 T20256 T20254 pobj buffer,with
R5801 T20257 T20252 punct .,eluted
R5802 T20259 T20260 aux To,ensure
R5803 T20260 T20262 advcl ensure,incubated
R5804 T20261 T20260 advmod further,ensure
R5805 T20263 T20264 compound antibody,specficity
R5806 T20264 T20260 dobj specficity,ensure
R5807 T20265 T20262 punct ", ",incubated
R5808 T20266 T20267 det the,antibodies
R5809 T20267 T20262 nsubjpass antibodies,incubated
R5810 T20268 T20267 amod purified,antibodies
R5811 T20269 T20262 auxpass were,incubated
R5812 T20270 T20262 advmod extensively,incubated
R5813 T20271 T20262 prep with,incubated
R5814 T20272 T20273 npadvmod Pygo1,homozygous
R5815 T20273 T20278 amod homozygous,embryo
R5816 T20274 T20272 punct /,Pygo1
R5817 T20275 T20272 nummod 2,Pygo1
R5818 T20276 T20273 amod double,homozygous
R5819 T20277 T20273 punct -,homozygous
R5820 T20278 T20280 compound embryo,extract
R5821 T20279 T20278 compound mutant,embryo
R5822 T20280 T20271 pobj extract,with
R5823 T20281 T20262 prep before,incubated
R5824 T20282 T20281 pobj use,before
R5825 T20283 T20262 punct .,incubated
R5826 T20633 T20634 compound BAT,gal
R5827 T20634 T20636 compound gal,transgene
R5828 T20635 T20634 punct -,gal
R5829 T20636 T20637 compound transgene,reporter
R5830 T20637 T20638 compound reporter,assay
R5831 T20639 T20638 prep of,assay
R5832 T20640 T20641 amod canonical,signaling
R5833 T20641 T20639 pobj signaling,of
R5834 T20642 T20641 compound Wnt,signaling
R5835 T20644 T20645 compound X,gal
R5836 T20645 T20647 compound gal,staining
R5837 T20646 T20645 punct -,gal
R5838 T20647 T20648 nsubjpass staining,performed
R5839 T20649 T20647 prep of,staining
R5840 T20650 T20651 preconj both,embryos
R5841 T20651 T20649 pobj embryos,of
R5842 T20652 T20651 cc and,embryos
R5843 T20653 T20654 amod developing,kidneys
R5844 T20654 T20651 conj kidneys,embryos
R5845 T20655 T20648 auxpass was,performed
R5846 T20656 T20657 mark as,described
R5847 T20657 T20648 advcl described,performed
R5848 T20658 T20657 advmod previously,described
R5849 T20659 T20660 punct [,21
R5850 T20660 T20657 parataxis 21,described
R5851 T20661 T20660 punct ],21
R5852 T20662 T20648 punct .,performed
R5853 T20664 T20665 nsubjpass Care,taken
R5854 T20666 T20665 auxpass was,taken
R5855 T20667 T20668 aux to,reduce
R5856 T20668 T20665 advcl reduce,taken
R5857 T20669 T20670 amod endogenous,activity
R5858 T20670 T20668 dobj activity,reduce
R5859 T20671 T20672 compound β,galactosidase
R5860 T20672 T20670 compound galactosidase,activity
R5861 T20673 T20672 punct -,galactosidase
R5862 T20674 T20668 prep within,reduce
R5863 T20675 T20676 det the,kidney
R5864 T20676 T20674 pobj kidney,within
R5865 T20677 T20676 amod developing,kidney
R5866 T20678 T20668 prep by,reduce
R5867 T20679 T20678 pcomp increasing,by
R5868 T20680 T20679 dobj pH,increasing
R5869 T20681 T20680 prep of,pH
R5870 T20682 T20683 det the,solution
R5871 T20683 T20681 pobj solution,of
R5872 T20684 T20685 compound X,gal
R5873 T20685 T20687 compound gal,staining
R5874 T20686 T20685 punct -,gal
R5875 T20687 T20683 compound staining,solution
R5876 T20688 T20679 prep to,increasing
R5877 T20689 T20688 pobj 8.0,to
R5878 T20690 T20665 punct .,taken
R5879 T20692 T20693 nsubjpass Changes,quantitated
R5880 T20694 T20692 prep in,Changes
R5881 T20695 T20696 compound transgene,Gal
R5882 T20696 T20699 compound Gal,expression
R5883 T20697 T20696 compound β,Gal
R5884 T20698 T20696 punct -,Gal
R5885 T20699 T20694 pobj expression,in
R5886 T20700 T20693 auxpass were,quantitated
R5887 T20701 T20693 advcl using,quantitated
R5888 T20702 T20703 det a,kit
R5889 T20703 T20701 dobj kit,using
R5890 T20704 T20705 nmod β,Gal
R5891 T20705 T20703 nmod Gal,kit
R5892 T20706 T20705 punct -,Gal
R5893 T20707 T20703 nmod ELISA,kit
R5894 T20708 T20707 punct (,ELISA
R5895 T20709 T20710 npadvmod Enzyme,linked
R5896 T20710 T20712 amod linked,immunoassay
R5897 T20711 T20710 punct -,linked
R5898 T20712 T20707 appos immunoassay,ELISA
R5899 T20713 T20703 punct ),kit
R5900 T20714 T20715 punct (,Roche
R5901 T20715 T20703 parataxis Roche,kit
R5902 T20716 T20715 punct ", ",Roche
R5903 T20717 T20715 npadvmod Indianapolis,Roche
R5904 T20718 T20715 punct ", ",Roche
R5905 T20719 T20715 npadvmod IN,Roche
R5906 T20720 T20715 punct ),Roche
R5907 T20721 T20693 punct ", ",quantitated
R5908 T20722 T20693 advcl normalizing,quantitated
R5909 T20723 T20722 prep according,normalizing
R5910 T20724 T20723 prep to,according
R5911 T20725 T20726 amod total,protein
R5912 T20726 T20724 pobj protein,to
R5913 T20727 T20693 punct .,quantitated
R5914 T20729 T20730 det Each,genotype
R5915 T20730 T20731 nsubjpass genotype,represented
R5916 T20732 T20731 auxpass was,represented
R5917 T20733 T20731 agent by,represented
R5918 T20734 T20735 det a,size
R5919 T20735 T20733 pobj size,by
R5920 T20736 T20735 compound sample,size
R5921 T20737 T20735 prep of,size
R5922 T20738 T20737 pobj 4,of
R5923 T20739 T20731 prep except,represented
R5924 T20740 T20741 det the,groups
R5925 T20741 T20739 pobj groups,except
R5926 T20742 T20741 amod non-transgenic,groups
R5927 T20743 T20744 punct (,5
R5928 T20744 T20742 parataxis 5,non-transgenic
R5929 T20745 T20744 nsubj n,5
R5930 T20746 T20744 punct =,5
R5931 T20747 T20744 punct ),5
R5932 T20748 T20742 punct ", ",non-transgenic
R5933 T20749 T20742 conj Pygo1,non-transgenic
R5934 T20750 T20749 punct +,Pygo1
R5935 T20751 T20749 punct /,Pygo1
R5936 T20752 T20749 punct -,Pygo1
R5937 T20753 T20749 punct ;,Pygo1
R5938 T20754 T20749 appos Pygo2,Pygo1
R5939 T20755 T20754 punct +,Pygo2
R5940 T20756 T20754 punct /,Pygo2
R5941 T20757 T20754 punct +,Pygo2
R5942 T20758 T20759 punct (,6
R5943 T20759 T20749 parataxis 6,Pygo1
R5944 T20760 T20759 nsubj n,6
R5945 T20761 T20759 punct =,6
R5946 T20762 T20759 punct ),6
R5947 T20763 T20749 punct ", ",Pygo1
R5948 T20764 T20749 conj Pygo1,Pygo1
R5949 T20765 T20764 punct -,Pygo1
R5950 T20766 T20764 punct /,Pygo1
R5951 T20767 T20764 punct -,Pygo1
R5952 T20768 T20764 punct ;,Pygo1
R5953 T20769 T20764 appos Pygo2,Pygo1
R5954 T20770 T20769 punct +,Pygo2
R5955 T20771 T20769 punct /,Pygo2
R5956 T20772 T20769 punct -,Pygo2
R5957 T20773 T20774 punct (,8
R5958 T20774 T20764 parataxis 8,Pygo1
R5959 T20775 T20774 nsubj n,8
R5960 T20776 T20774 punct =,8
R5961 T20777 T20774 punct ),8
R5962 T20778 T20764 punct ", ",Pygo1
R5963 T20779 T20764 cc and,Pygo1
R5964 T20780 T20764 conj Pygo1,Pygo1
R5965 T20781 T20780 punct -,Pygo1
R5966 T20782 T20780 punct /,Pygo1
R5967 T20783 T20780 punct -,Pygo1
R5968 T20784 T20780 punct ;,Pygo1
R5969 T20785 T20780 appos Pygo2,Pygo1
R5970 T20786 T20785 punct -,Pygo2
R5971 T20787 T20785 punct /,Pygo2
R5972 T20788 T20785 punct -,Pygo2
R5973 T20789 T20790 punct (,6
R5974 T20790 T20780 parataxis 6,Pygo1
R5975 T20791 T20790 nsubj n,6
R5976 T20792 T20790 punct =,6
R5977 T20793 T20790 punct ),6
R5978 T20794 T20731 punct .,represented
R5979 T21192 T21193 compound Microarray,analysis
R5980 T21195 T21196 amod Total,RNA
R5981 T21196 T21197 nsubjpass RNA,isolated
R5982 T21198 T21197 auxpass was,isolated
R5983 T21199 T21197 prep from,isolated
R5984 T21200 T21201 compound E18.5,kidneys
R5985 T21201 T21199 pobj kidneys,from
R5986 T21202 T21201 acl dissected,kidneys
R5987 T21203 T21202 prep from,dissected
R5988 T21204 T21205 amod normal,embryos
R5989 T21205 T21203 pobj embryos,from
R5990 T21206 T21204 cc and,normal
R5991 T21207 T21208 compound Pygo1,Pygo2
R5992 T21208 T21210 npadvmod Pygo2,null
R5993 T21209 T21208 punct /,Pygo2
R5994 T21210 T21204 conj null,normal
R5995 T21211 T21210 npadvmod compound,null
R5996 T21212 T21197 advcl using,isolated
R5997 T21213 T21214 det a,kit
R5998 T21214 T21212 dobj kit,using
R5999 T21215 T21214 amod commercial,kit
R6000 T21216 T21214 punct (,kit
R6001 T21217 T21218 compound Stratagene,Kit
R6002 T21218 T21214 appos Kit,kit
R6003 T21219 T21218 compound Absolutely,Kit
R6004 T21220 T21218 compound RNA,Kit
R6005 T21221 T21218 compound Microprep,Kit
R6006 T21222 T21223 punct ;,USA
R6007 T21223 T21214 parataxis USA,kit
R6008 T21224 T21225 compound La,Jolla
R6009 T21225 T21223 npadvmod Jolla,USA
R6010 T21226 T21223 punct ", ",USA
R6011 T21227 T21223 npadvmod CA,USA
R6012 T21228 T21223 punct ", ",USA
R6013 T21229 T21223 punct ),USA
R6014 T21230 T21197 punct .,isolated
R6015 T21232 T21233 det An,aliquot
R6016 T21233 T21234 nsubjpass aliquot,processed
R6017 T21235 T21236 punct (,ng
R6018 T21236 T21233 parataxis ng,aliquot
R6019 T21237 T21236 nummod 300,ng
R6020 T21238 T21236 punct ),ng
R6021 T21239 T21233 prep of,aliquot
R6022 T21240 T21241 amod total,RNA
R6023 T21241 T21239 pobj RNA,of
R6024 T21242 T21234 auxpass was,processed
R6025 T21243 T21234 cc and,processed
R6026 T21244 T21234 conj labeled,processed
R6027 T21245 T21244 advcl using,labeled
R6028 T21246 T21247 det a,kit
R6029 T21247 T21245 dobj kit,using
R6030 T21248 T21247 amod commercial,kit
R6031 T21249 T21247 punct (,kit
R6032 T21250 T21251 nmod TargetAmp,Ki
R6033 T21251 T21247 appos Ki,kit
R6034 T21252 T21253 nummod 1,Round
R6035 T21253 T21251 nmod Round,Ki
R6036 T21254 T21253 punct -,Round
R6037 T21255 T21256 compound Aminoallyl,aRNA
R6038 T21256 T21251 compound aRNA,Ki
R6039 T21257 T21256 punct -,aRNA
R6040 T21258 T21259 punct ;,Epicentre
R6041 T21259 T21247 parataxis Epicentre,kit
R6042 T21260 T21259 punct ", ",Epicentre
R6043 T21261 T21259 npadvmod Madison,Epicentre
R6044 T21262 T21259 punct ", ",Epicentre
R6045 T21263 T21259 npadvmod WI,Epicentre
R6046 T21264 T21259 punct ", ",Epicentre
R6047 T21265 T21259 npadvmod USA,Epicentre
R6048 T21266 T21259 punct ),Epicentre
R6049 T21267 T21234 punct .,processed
R6050 T21269 T21270 amod Labeled,RNA
R6051 T21270 T21271 nsubjpass RNA,hybridized
R6052 T21272 T21271 auxpass was,hybridized
R6053 T21273 T21271 prep to,hybridized
R6054 T21274 T21273 pobj microarrays,to
R6055 T21275 T21274 punct (,microarrays
R6056 T21276 T21277 nmod Sentrix,Beadchip
R6057 T21277 T21274 appos Beadchip,microarrays
R6058 T21278 T21277 nmod Mouse,Beadchip
R6059 T21279 T21278 punct -,Mouse
R6060 T21280 T21278 nummod 6,Mouse
R6061 T21281 T21277 compound expression,Beadchip
R6062 T21282 T21283 punct ;,Illumina
R6063 T21283 T21274 parataxis Illumina,microarrays
R6064 T21284 T21283 punct ", ",Illumina
R6065 T21285 T21286 compound San,Diego
R6066 T21286 T21283 npadvmod Diego,Illumina
R6067 T21287 T21283 punct ", ",Illumina
R6068 T21288 T21283 npadvmod CA,Illumina
R6069 T21289 T21283 punct ),Illumina
R6070 T21290 T21274 acl providing,microarrays
R6071 T21291 T21290 dobj coverage,providing
R6072 T21292 T21291 prep of,coverage
R6073 T21293 T21294 quantmod over,47000
R6074 T21294 T21295 nummod 47000,genes
R6075 T21295 T21292 pobj genes,of
R6076 T21296 T21271 cc and,hybridized
R6077 T21297 T21271 conj expressed,hybridized
R6078 T21298 T21299 compound sequence,tags
R6079 T21299 T21297 dobj tags,expressed
R6080 T21300 T21301 mark as,described
R6081 T21301 T21297 advcl described,expressed
R6082 T21302 T21301 advmod previously,described
R6083 T21303 T21304 punct [,36
R6084 T21304 T21301 parataxis 36,described
R6085 T21305 T21304 punct ],36
R6086 T21306 T21271 punct .,hybridized
R6087 T21308 T21309 compound Microarray,analysis
R6088 T21309 T21310 nsubjpass analysis,performed
R6089 T21311 T21309 prep of,analysis
R6090 T21312 T21313 compound Pygo1,Pygo2
R6091 T21313 T21315 npadvmod Pygo2,null
R6092 T21314 T21313 punct /,Pygo2
R6093 T21315 T21311 pobj null,of
R6094 T21316 T21315 cc and,null
R6095 T21317 T21318 amod normal,type
R6096 T21318 T21321 compound type,kidneys
R6097 T21319 T21318 amod wild,type
R6098 T21320 T21318 punct -,type
R6099 T21321 T21315 conj kidneys,null
R6100 T21322 T21310 auxpass was,performed
R6101 T21323 T21310 prep in,performed
R6102 T21324 T21325 amod biological,triplicate
R6103 T21325 T21323 pobj triplicate,in
R6104 T21326 T21310 punct .,performed
R6105 T21328 T21329 amod Raw,intensities
R6106 T21329 T21331 nsubjpass intensities,obtained
R6107 T21330 T21329 compound signal,intensities
R6108 T21332 T21329 prep of,intensities
R6109 T21333 T21334 det each,probe
R6110 T21334 T21332 pobj probe,of
R6111 T21335 T21331 auxpass were,obtained
R6112 T21336 T21331 prep from,obtained
R6113 T21337 T21338 compound data,software
R6114 T21338 T21336 pobj software,from
R6115 T21339 T21338 compound analysis,software
R6116 T21340 T21338 punct (,software
R6117 T21341 T21338 appos Beadstudio,software
R6118 T21342 T21343 punct ;,Illumina
R6119 T21343 T21338 parataxis Illumina,software
R6120 T21344 T21343 punct ),Illumina
R6121 T21345 T21331 cc and,obtained
R6122 T21346 T21331 conj imported,obtained
R6123 T21347 T21346 prep into,imported
R6124 T21348 T21349 compound GeneSpring,GX
R6125 T21349 T21347 pobj GX,into
R6126 T21350 T21349 nummod 7.3,GX
R6127 T21351 T21352 punct (,Technologies
R6128 T21352 T21349 parataxis Technologies,GX
R6129 T21353 T21352 compound Agilent,Technologies
R6130 T21354 T21352 punct ", ",Technologies
R6131 T21355 T21356 compound Palo,Alto
R6132 T21356 T21352 npadvmod Alto,Technologies
R6133 T21357 T21352 punct ", ",Technologies
R6134 T21358 T21352 npadvmod CA,Technologies
R6135 T21359 T21352 punct ", ",Technologies
R6136 T21360 T21352 npadvmod USA,Technologies
R6137 T21361 T21352 punct ),Technologies
R6138 T21362 T21331 punct .,obtained
R6139 T21364 T21365 nsubjpass Genes,selected
R6140 T21366 T21365 auxpass were,selected
R6141 T21367 T21365 prep on,selected
R6142 T21368 T21369 det the,basis
R6143 T21369 T21367 pobj basis,on
R6144 T21370 T21369 prep of,basis
R6145 T21371 T21372 amod greater,two-fold
R6146 T21372 T21374 nummod two-fold,change
R6147 T21373 T21372 quantmod than,two-fold
R6148 T21374 T21370 pobj change,of
R6149 T21375 T21374 amod average,change
R6150 T21376 T21374 compound fold,change
R6151 T21377 T21374 cc and,change
R6152 T21378 T21379 amod statistical,significance
R6153 T21379 T21374 conj significance,change
R6154 T21380 T21381 punct (,0.05
R6155 T21381 T21379 parataxis 0.05,significance
R6156 T21382 T21383 compound p,value
R6157 T21383 T21381 nsubj value,0.05
R6158 T21384 T21383 punct -,value
R6159 T21385 T21381 punct <,0.05
R6160 T21386 T21381 punct ),0.05
R6161 T21387 T21365 punct .,selected
R6162 T21389 T21390 advmod Previously,described
R6163 T21390 T21391 amod described,genes
R6164 T21391 T21394 nsubjpass genes,obtained
R6165 T21392 T21391 compound Wnt,genes
R6166 T21393 T21391 compound target,genes
R6167 T21395 T21394 auxpass were,obtained
R6168 T21396 T21394 prep from,obtained
R6169 T21397 T21394 punct .,obtained
R6170 T21853 T21854 amod Quantitative,validation
R6171 T21855 T21854 compound PCR,validation
R6172 T21856 T21854 prep of,validation
R6173 T21857 T21858 compound microarray,results
R6174 T21858 T21856 pobj results,of
R6175 T21860 T21861 amod Total,RNA
R6176 T21861 T21862 nsubjpass RNA,purified
R6177 T21863 T21861 prep from,RNA
R6178 T21864 T21865 nmod E18.5,kidneys
R6179 T21865 T21863 pobj kidneys,from
R6180 T21866 T21867 compound Pygo1,Pygo2
R6181 T21867 T21869 npadvmod Pygo2,null
R6182 T21868 T21867 punct /,Pygo2
R6183 T21869 T21865 amod null,kidneys
R6184 T21870 T21869 cc and,null
R6185 T21871 T21869 conj control,null
R6186 T21872 T21861 punct (,RNA
R6187 T21873 T21874 preconj both,represented
R6188 T21874 T21861 acl represented,RNA
R6189 T21875 T21874 prep in,represented
R6190 T21876 T21875 pobj duplicate,in
R6191 T21877 T21874 cc and,represented
R6192 T21878 T21874 conj distinct,represented
R6193 T21879 T21878 prep from,distinct
R6194 T21880 T21881 det the,kidneys
R6195 T21881 T21879 pobj kidneys,from
R6196 T21882 T21881 acl used,kidneys
R6197 T21883 T21882 prep for,used
R6198 T21884 T21885 compound microrray,analysis
R6199 T21885 T21883 pobj analysis,for
R6200 T21886 T21862 punct ),purified
R6201 T21887 T21862 auxpass was,purified
R6202 T21888 T21862 advcl using,purified
R6203 T21889 T21890 det a,kit
R6204 T21890 T21888 dobj kit,using
R6205 T21891 T21890 amod commercial,kit
R6206 T21892 T21890 punct (,kit
R6207 T21893 T21894 compound Absolutely,Kit
R6208 T21894 T21890 appos Kit,kit
R6209 T21895 T21894 compound RNA,Kit
R6210 T21896 T21894 compound Microprep,Kit
R6211 T21897 T21898 punct ;,Stratagene
R6212 T21898 T21890 parataxis Stratagene,kit
R6213 T21899 T21898 punct ", ",Stratagene
R6214 T21900 T21901 compound La,Jolla
R6215 T21901 T21898 npadvmod Jolla,Stratagene
R6216 T21902 T21898 punct ", ",Stratagene
R6217 T21903 T21904 compound CA,USA
R6218 T21904 T21898 npadvmod USA,Stratagene
R6219 T21905 T21898 punct ),Stratagene
R6220 T21906 T21890 prep including,kit
R6221 T21907 T21908 compound DNAse1,treatment
R6222 T21908 T21906 pobj treatment,including
R6223 T21909 T21862 punct .,purified
R6224 T21911 T21912 nsubjpass cDNA,generated
R6225 T21913 T21912 auxpass was,generated
R6226 T21914 T21912 advcl using,generated
R6227 T21915 T21916 amod random,hexamers
R6228 T21916 T21914 dobj hexamers,using
R6229 T21917 T21914 prep according,using
R6230 T21918 T21917 prep to,according
R6231 T21919 T21920 amod conventional,protocols
R6232 T21920 T21918 pobj protocols,to
R6233 T21921 T21922 punct (,Invitrogen
R6234 T21922 T21920 parataxis Invitrogen,protocols
R6235 T21923 T21922 punct ", ",Invitrogen
R6236 T21924 T21922 npadvmod Carlsbad,Invitrogen
R6237 T21925 T21922 punct ", ",Invitrogen
R6238 T21926 T21922 npadvmod CA,Invitrogen
R6239 T21927 T21922 punct ", ",Invitrogen
R6240 T21928 T21922 npadvmod USA,Invitrogen
R6241 T21929 T21922 punct ),Invitrogen
R6242 T21930 T21912 punct .,generated
R6243 T21932 T21933 det The,primers
R6244 T21933 T21935 nsubjpass primers,generated
R6245 T21934 T21933 amod following,primers
R6246 T21936 T21935 auxpass were,generated
R6247 T21937 T21938 aux to,include
R6248 T21938 T21935 advcl include,generated
R6249 T21939 T21940 det the,sequence
R6250 T21940 T21938 dobj sequence,include
R6251 T21941 T21940 acl obtained,sequence
R6252 T21942 T21941 prep from,obtained
R6253 T21943 T21944 det the,probe
R6254 T21944 T21942 pobj probe,from
R6255 T21945 T21944 compound Illumina,probe
R6256 T21946 T21935 punct : ,generated
R6257 T21947 T21935 dobj Actb,generated
R6258 T21948 T21949 punct (,ACATCTGCTGGAAGGTGGAC
R6259 T21949 T21947 parataxis ACATCTGCTGGAAGGTGGAC,Actb
R6260 T21950 T21949 nmod TTGCTGACAGGATGCAGAAG,ACATCTGCTGGAAGGTGGAC
R6261 T21951 T21949 punct ", ",ACATCTGCTGGAAGGTGGAC
R6262 T21952 T21949 punct ),ACATCTGCTGGAAGGTGGAC
R6263 T21953 T21947 punct ;,Actb
R6264 T21954 T21947 conj Aldh1a7,Actb
R6265 T21955 T21956 punct (,GAGTTACAGAGAGCTTGCACCTT
R6266 T21956 T21954 parataxis GAGTTACAGAGAGCTTGCACCTT,Aldh1a7
R6267 T21957 T21956 nmod CCAGAAAGTGGTGTTTTGCT,GAGTTACAGAGAGCTTGCACCTT
R6268 T21958 T21956 punct ", ",GAGTTACAGAGAGCTTGCACCTT
R6269 T21959 T21956 punct ),GAGTTACAGAGAGCTTGCACCTT
R6270 T21960 T21954 punct ;,Aldh1a7
R6271 T21961 T21954 conj Col8a1,Aldh1a7
R6272 T21962 T21963 punct (,TGTGTACATCATGGGCTCGT
R6273 T21963 T21961 parataxis TGTGTACATCATGGGCTCGT,Col8a1
R6274 T21964 T21963 nmod GCAGACAGGCATCTTCACCT,TGTGTACATCATGGGCTCGT
R6275 T21965 T21963 punct ", ",TGTGTACATCATGGGCTCGT
R6276 T21966 T21963 punct ),TGTGTACATCATGGGCTCGT
R6277 T21967 T21961 punct ;,Col8a1
R6278 T21968 T21961 conj Csrp1,Col8a1
R6279 T21969 T21970 punct (,TGGGCAAGGTAGTGAAGGTT
R6280 T21970 T21968 parataxis TGGGCAAGGTAGTGAAGGTT,Csrp1
R6281 T21971 T21970 nmod CAGCATAGCCCAGGGTAGAG,TGGGCAAGGTAGTGAAGGTT
R6282 T21972 T21970 punct ", ",TGGGCAAGGTAGTGAAGGTT
R6283 T21973 T21970 punct ),TGGGCAAGGTAGTGAAGGTT
R6284 T21974 T21968 punct ;,Csrp1
R6285 T21975 T21968 conj Klk5,Csrp1
R6286 T21976 T21977 punct (,TTGCCTCCATCCATATCTCC
R6287 T21977 T21975 parataxis TTGCCTCCATCCATATCTCC,Klk5
R6288 T21978 T21977 nmod GCAGCATTACACCCGTCATA,TTGCCTCCATCCATATCTCC
R6289 T21979 T21977 punct ", ",TTGCCTCCATCCATATCTCC
R6290 T21980 T21977 punct ),TTGCCTCCATCCATATCTCC
R6291 T21981 T21975 punct ;,Klk5
R6292 T21982 T21975 conj Picalm,Klk5
R6293 T21983 T21984 punct (,GCACCGATCAACAGTGCAG
R6294 T21984 T21982 parataxis GCACCGATCAACAGTGCAG,Picalm
R6295 T21985 T21984 nmod GGGAGGGAACAGAAATCCTT,GCACCGATCAACAGTGCAG
R6296 T21986 T21984 punct ", ",GCACCGATCAACAGTGCAG
R6297 T21987 T21984 punct ),GCACCGATCAACAGTGCAG
R6298 T21988 T21982 punct ;,Picalm
R6299 T21989 T21982 conj Pygo2,Picalm
R6300 T21990 T21991 punct (,AACTTCCTCCAGCCCATTTT
R6301 T21991 T21989 parataxis AACTTCCTCCAGCCCATTTT,Pygo2
R6302 T21992 T21991 nmod TTCTGGGAACTTGTGCACTG,AACTTCCTCCAGCCCATTTT
R6303 T21993 T21991 punct ", ",AACTTCCTCCAGCCCATTTT
R6304 T21994 T21991 punct ),AACTTCCTCCAGCCCATTTT
R6305 T21995 T21989 punct ;,Pygo2
R6306 T21996 T21989 conj Ren2,Pygo2
R6307 T21997 T21998 punct (,TGTGCACAGCTTGTCTCTCC
R6308 T21998 T21996 parataxis TGTGCACAGCTTGTCTCTCC,Ren2
R6309 T21999 T21998 nmod TTGTGAGCTGTAGCCAGGTG,TGTGCACAGCTTGTCTCTCC
R6310 T22000 T21998 punct ", ",TGTGCACAGCTTGTCTCTCC
R6311 T22001 T21998 punct ),TGTGCACAGCTTGTCTCTCC
R6312 T22002 T21996 cc and,Ren2
R6313 T22003 T21996 conj Tia1,Ren2
R6314 T22004 T22005 punct (,AGCCCCAGAGGACAATTTTT
R6315 T22005 T22003 parataxis AGCCCCAGAGGACAATTTTT,Tia1
R6316 T22006 T22005 nmod TGATTGAAGGGCTACTAGAGTGGT,AGCCCCAGAGGACAATTTTT
R6317 T22007 T22005 punct ", ",AGCCCCAGAGGACAATTTTT
R6318 T22008 T22005 punct ),AGCCCCAGAGGACAATTTTT
R6319 T22009 T21935 advcl using,generated
R6320 T22010 T22011 compound Primer3,software
R6321 T22011 T22009 dobj software,using
R6322 T22012 T22013 punct [,37
R6323 T22013 T22011 parataxis 37,software
R6324 T22014 T22013 punct ],37
R6325 T22015 T21935 punct .,generated
R6326 T22017 T22018 amod Relative,PCR
R6327 T22018 T22020 nsubjpass PCR,performed
R6328 T22019 T22018 amod quantitative,PCR
R6329 T22021 T22020 auxpass was,performed
R6330 T22022 T22020 prep according,performed
R6331 T22023 T22022 prep to,according
R6332 T22024 T22025 det the,protocol
R6333 T22025 T22023 pobj protocol,to
R6334 T22026 T22025 amod conventional,protocol
R6335 T22027 T22028 compound SYBR,Green
R6336 T22028 T22025 compound Green,protocol
R6337 T22029 T22030 punct (,Stratagene
R6338 T22030 T22025 parataxis Stratagene,protocol
R6339 T22031 T22030 punct ),Stratagene
R6340 T22032 T22020 advcl using,performed
R6341 T22033 T22034 det a,system
R6342 T22034 T22032 dobj system,using
R6343 T22035 T22034 amod quantitative,system
R6344 T22036 T22034 compound PCR,system
R6345 T22037 T22038 punct (,Stratagene
R6346 T22038 T22032 parataxis Stratagene,using
R6347 T22039 T22038 dep Mx3000p,Stratagene
R6348 T22040 T22038 punct ;,Stratagene
R6349 T22041 T22038 punct ),Stratagene
R6350 T22042 T22020 punct .,performed
R6351 T22044 T22045 nmod Dissociation,curve
R6352 T22045 T22046 nmod curve,analysis
R6353 T22046 T22051 nsubjpass analysis,used
R6354 T22047 T22045 cc and,curve
R6355 T22048 T22049 compound agarose,gel
R6356 T22049 T22045 conj gel,curve
R6357 T22050 T22049 punct -,gel
R6358 T22052 T22046 prep of,analysis
R6359 T22053 T22054 det each,primer
R6360 T22054 T22052 pobj primer,of
R6361 T22055 T22054 amod set,primer
R6362 T22056 T22051 auxpass were,used
R6363 T22057 T22058 aux to,insure
R6364 T22058 T22051 advcl insure,used
R6365 T22059 T22058 dobj specificity,insure
R6366 T22060 T22059 prep of,specificity
R6367 T22061 T22062 det the,amplicon
R6368 T22062 T22060 pobj amplicon,of
R6369 T22063 T22051 punct .,used
R6370 T22065 T22066 det All,data
R6371 T22066 T22067 nsubjpass data,normalized
R6372 T22068 T22067 auxpass were,normalized
R6373 T22069 T22067 prep to,normalized
R6374 T22070 T22071 det an,control
R6375 T22071 T22069 pobj control,to
R6376 T22072 T22071 amod internal,control
R6377 T22073 T22071 compound housekeeping,control
R6378 T22074 T22071 punct (,control
R6379 T22075 T22071 appos Actb,control
R6380 T22076 T22067 punct ),normalized
R6381 T22077 T22067 cc and,normalized
R6382 T22078 T22067 conj analyzed,normalized
R6383 T22079 T22078 advcl using,analyzed
R6384 T22080 T22081 det the,method
R6385 T22081 T22079 dobj method,using
R6386 T22082 T22083 nummod 2,T
R6387 T22083 T22081 nmod T,method
R6388 T22084 T22083 punct (,T
R6389 T22085 T22083 punct -,T
R6390 T22086 T22083 nmod Delta,T
R6391 T22087 T22083 nmod Delta,T
R6392 T22088 T22083 nmod C,T
R6393 T22089 T22083 punct (,T
R6394 T22090 T22083 punct ),T
R6395 T22091 T22083 punct ),T
R6396 T22092 T22093 punct [,38
R6397 T22093 T22078 parataxis 38,analyzed
R6398 T22094 T22093 punct ],38
R6399 T22095 T22067 punct .,normalized
R6400 T22293 T22294 compound Pygo1,Pygo2
R6401 T22294 T22296 compound Pygo2,mutant
R6402 T22295 T22294 punct /,Pygo2
R6403 T22296 T22297 compound mutant,embryos
R6404 T22298 T22297 punct .,embryos
R6405 T22300 T22301 punct (,A
R6406 T22301 T22302 meta A,appeared
R6407 T22303 T22301 punct ),A
R6408 T22304 T22305 nmod E18.5,embryos
R6409 T22305 T22302 nsubj embryos,appeared
R6410 T22306 T22305 nmod Pygo1,embryos
R6411 T22307 T22306 punct -,Pygo1
R6412 T22308 T22306 punct /,Pygo1
R6413 T22309 T22306 punct -,Pygo1
R6414 T22310 T22306 punct /,Pygo1
R6415 T22311 T22306 appos Pygo2,Pygo1
R6416 T22312 T22311 punct +,Pygo2
R6417 T22313 T22311 punct /,Pygo2
R6418 T22314 T22311 punct -,Pygo2
R6419 T22315 T22305 punct ", ",embryos
R6420 T22316 T22305 prep with,embryos
R6421 T22317 T22318 advmod only,allele
R6422 T22318 T22316 pobj allele,with
R6423 T22319 T22318 nummod one,allele
R6424 T22320 T22321 amod wild,type
R6425 T22321 T22318 compound type,allele
R6426 T22322 T22321 punct -,type
R6427 T22323 T22318 compound Pygo2,allele
R6428 T22324 T22302 punct ", ",appeared
R6429 T22325 T22302 oprd normal,appeared
R6430 T22326 T22302 punct .,appeared
R6431 T22328 T22329 punct (,B
R6432 T22329 T22330 meta B,were
R6433 T22331 T22329 punct ", ",B
R6434 T22332 T22329 dep C,B
R6435 T22333 T22329 punct ),B
R6436 T22334 T22335 amod Double,homozygous
R6437 T22335 T22336 amod homozygous,mutant
R6438 T22336 T22337 nmod mutant,embryos
R6439 T22337 T22330 nsubj embryos,were
R6440 T22338 T22337 nmod Pygo1,embryos
R6441 T22339 T22338 punct -,Pygo1
R6442 T22340 T22338 punct /,Pygo1
R6443 T22341 T22338 punct -,Pygo1
R6444 T22342 T22338 punct /,Pygo1
R6445 T22343 T22338 appos Pygo2,Pygo1
R6446 T22344 T22343 punct -,Pygo2
R6447 T22345 T22343 punct /,Pygo2
R6448 T22346 T22343 punct -,Pygo2
R6449 T22347 T22330 acomp smaller,were
R6450 T22348 T22330 punct ", ",were
R6451 T22349 T22330 prep with,were
R6452 T22350 T22351 compound eye,defects
R6453 T22351 T22349 pobj defects,with
R6454 T22352 T22351 prep including,defects
R6455 T22353 T22354 amod absent,lens
R6456 T22354 T22352 pobj lens,including
R6457 T22355 T22353 cc or,absent
R6458 T22356 T22353 conj rudimentary,absent
R6459 T22357 T22354 cc and,lens
R6460 T22358 T22359 amod folded,retina
R6461 T22359 T22354 conj retina,lens
R6462 T22360 T22359 amod pigmented,retina
R6463 T22361 T22362 punct (,arrows
R6464 T22362 T22330 parataxis arrows,were
R6465 T22363 T22362 punct ),arrows
R6466 T22364 T22330 punct .,were
R6467 T22366 T22367 punct (,C
R6468 T22367 T22368 meta C,displayed
R6469 T22369 T22367 punct ),C
R6470 T22370 T22371 det A,percentage
R6471 T22371 T22368 nsubj percentage,displayed
R6472 T22372 T22371 amod small,percentage
R6473 T22373 T22371 prep of,percentage
R6474 T22374 T22375 compound Pygo1,Pygo2
R6475 T22375 T22377 npadvmod Pygo2,null
R6476 T22376 T22375 punct /,Pygo2
R6477 T22377 T22378 amod null,embryos
R6478 T22378 T22373 pobj embryos,of
R6479 T22379 T22368 advmod also,displayed
R6480 T22380 T22368 dobj exencephaly,displayed
R6481 T22381 T22368 punct .,displayed
R6484 T22637 T22638 nmod Pygo1,expression
R6485 T22639 T22637 cc and,Pygo1
R6486 T22640 T22637 conj Pygo2,Pygo1
R6487 T22641 T22638 prep in,expression
R6488 T22642 T22643 det the,kidney
R6489 T22643 T22641 pobj kidney,in
R6490 T22644 T22643 nmod E18.5,kidney
R6491 T22645 T22643 amod developing,kidney
R6492 T22646 T22638 punct .,expression
R6493 T22648 T22649 nsubjpass Immunofluorescence,used
R6494 T22650 T22649 auxpass was,used
R6495 T22651 T22652 aux to,determine
R6496 T22652 T22649 advcl determine,used
R6497 T22653 T22654 compound expression,patterns
R6498 T22654 T22652 dobj patterns,determine
R6499 T22655 T22654 prep of,patterns
R6500 T22656 T22657 det the,proteins
R6501 T22657 T22655 pobj proteins,of
R6502 T22658 T22657 nmod Pygo1,proteins
R6503 T22659 T22658 cc and,Pygo1
R6504 T22660 T22658 conj Pygo2,Pygo1
R6505 T22661 T22654 prep in,patterns
R6506 T22662 T22663 det the,cortex
R6507 T22663 T22661 pobj cortex,in
R6508 T22664 T22663 prep of,cortex
R6509 T22665 T22666 det the,kidney
R6510 T22666 T22664 pobj kidney,of
R6511 T22667 T22666 compound E18.5,kidney
R6512 T22668 T22649 punct .,used
R6513 T22670 T22671 preconj Both,Pygo1
R6514 T22671 T22672 nsubjpass Pygo1,localized
R6515 T22673 T22671 cc and,Pygo1
R6516 T22674 T22671 conj Pygo2,Pygo1
R6517 T22675 T22676 punct (,red
R6518 T22676 T22674 parataxis red,Pygo2
R6519 T22677 T22676 punct ),red
R6520 T22678 T22672 auxpass were,localized
R6521 T22679 T22672 prep in,localized
R6522 T22680 T22681 det the,nucleus
R6523 T22681 T22679 pobj nucleus,in
R6524 T22682 T22672 punct ", ",localized
R6525 T22683 T22684 mark as,expected
R6526 T22684 T22672 advcl expected,localized
R6527 T22685 T22672 punct .,localized
R6528 T22687 T22688 det Both,genes
R6529 T22688 T22689 nsubj genes,showed
R6530 T22690 T22691 amod widespread,expression
R6531 T22691 T22689 dobj expression,showed
R6532 T22692 T22689 punct ", ",showed
R6533 T22693 T22689 prep with,showed
R6534 T22694 T22693 pobj signal,with
R6535 T22695 T22694 acl detected,signal
R6536 T22696 T22695 prep in,detected
R6537 T22697 T22698 det all,components
R6538 T22698 T22696 pobj components,in
R6539 T22699 T22698 prep of,components
R6540 T22700 T22701 det the,kidney
R6541 T22701 T22699 pobj kidney,of
R6542 T22702 T22701 amod developing,kidney
R6543 T22703 T22693 punct ", ",with
R6544 T22704 T22693 cc but,with
R6545 T22705 T22693 conj with,with
R6546 T22706 T22707 amod elevated,levels
R6547 T22707 T22705 pobj levels,with
R6548 T22708 T22707 prep in,levels
R6549 T22709 T22710 det the,compartment
R6550 T22710 T22708 pobj compartment,in
R6551 T22711 T22712 amod stromal,cell
R6552 T22712 T22710 compound cell,compartment
R6553 T22713 T22714 punct (,arrows
R6554 T22714 T22707 parataxis arrows,levels
R6555 T22715 T22714 punct ),arrows
R6556 T22716 T22689 punct .,showed
R6557 T22718 T22719 amod Epithelial,cells
R6558 T22719 T22720 nsubjpass cells,labeled
R6559 T22721 T22719 punct ", ",cells
R6560 T22722 T22723 advmod primarily,bud
R6561 T22723 T22719 appos bud,cells
R6562 T22724 T22723 amod ureteric,bud
R6563 T22725 T22719 prep in,cells
R6564 T22726 T22727 det these,sections
R6565 T22727 T22725 pobj sections,in
R6566 T22728 T22720 punct ", ",labeled
R6567 T22729 T22720 auxpass were,labeled
R6568 T22730 T22720 oprd blue,labeled
R6569 T22731 T22720 advcl using,labeled
R6570 T22732 T22733 compound E,cadherin
R6571 T22733 T22735 compound cadherin,antibody
R6572 T22734 T22733 punct -,cadherin
R6573 T22735 T22731 dobj antibody,using
R6574 T22736 T22720 punct .,labeled
R6575 T22738 T22739 amod Original,magnification
R6576 T22739 T22740 dep magnification,200
R6577 T22741 T22740 punct ×,200
R6578 T22742 T22740 punct .,200
R6579 T23117 T23118 amod Confocal,analysis
R6580 T23119 T23118 prep of,analysis
R6581 T23120 T23121 compound Pygo1,Pygo2
R6582 T23121 T23123 compound Pygo2,mutant
R6583 T23122 T23121 punct /,Pygo2
R6584 T23123 T23124 compound mutant,kidneys
R6585 T23124 T23119 pobj kidneys,of
R6586 T23125 T23124 compound E18.5,kidneys
R6587 T23126 T23118 punct .,analysis
R6588 T23128 T23129 punct (,B
R6589 T23129 T23130 meta B,stained
R6590 T23131 T23129 punct ", ",B
R6591 T23132 T23129 dep D,B
R6592 T23133 T23129 punct ),B
R6593 T23134 T23135 nmod Pygo1,mutant
R6594 T23135 T23144 compound mutant,kidneys
R6595 T23136 T23134 punct -,Pygo1
R6596 T23137 T23134 punct /,Pygo1
R6597 T23138 T23134 punct -,Pygo1
R6598 T23139 T23134 punct /,Pygo1
R6599 T23140 T23134 appos Pygo2,Pygo1
R6600 T23141 T23140 punct -,Pygo2
R6601 T23142 T23140 punct /,Pygo2
R6602 T23143 T23140 punct -,Pygo2
R6603 T23144 T23130 nsubjpass kidneys,stained
R6604 T23145 T23144 compound E18.5,kidneys
R6605 T23146 T23144 cc and,kidneys
R6606 T23147 T23148 punct (,C
R6607 T23148 T23151 parataxis C,kidneys
R6608 T23149 T23148 nmod A,C
R6609 T23150 T23148 punct ", ",C
R6610 T23151 T23144 conj kidneys,kidneys
R6611 T23152 T23148 punct ),C
R6612 T23153 T23151 prep of,kidneys
R6613 T23154 T23155 amod normal,littermates
R6614 T23155 T23153 pobj littermates,of
R6615 T23156 T23130 auxpass were,stained
R6616 T23157 T23130 advcl using,stained
R6617 T23158 T23157 dobj antibodies,using
R6618 T23159 T23158 prep to,antibodies
R6619 T23160 T23161 punct (,D
R6620 T23161 T23164 parataxis D,Cited1
R6621 T23162 T23161 nmod C,D
R6622 T23163 T23161 punct ", ",D
R6623 T23164 T23159 pobj Cited1,to
R6624 T23165 T23161 punct ),D
R6625 T23166 T23164 cc or,Cited1
R6626 T23167 T23168 punct (,B
R6627 T23168 T23171 parataxis B,Wt1
R6628 T23169 T23168 nmod A,B
R6629 T23170 T23168 punct ", ",B
R6630 T23171 T23164 conj Wt1,Cited1
R6631 T23172 T23168 punct ),B
R6632 T23173 T23164 punct ", ",Cited1
R6633 T23174 T23175 advmod both,expressed
R6634 T23175 T23164 acl expressed,Cited1
R6635 T23176 T23175 prep in,expressed
R6636 T23177 T23178 det the,mesenchyme
R6637 T23178 T23176 pobj mesenchyme,in
R6638 T23179 T23178 amod condensing,mesenchyme
R6639 T23180 T23178 amod metanephric,mesenchyme
R6640 T23181 T23175 punct ", ",expressed
R6641 T23182 T23175 cc and,expressed
R6642 T23183 T23175 conj colored,expressed
R6643 T23184 T23183 prep as,colored
R6644 T23185 T23184 pobj red,as
R6645 T23186 T23164 punct ", ",Cited1
R6646 T23187 T23164 conj Cdh1,Cited1
R6647 T23188 T23187 punct ", ",Cdh1
R6648 T23189 T23190 det a,marker
R6649 T23190 T23187 appos marker,Cdh1
R6650 T23191 T23190 amod general,marker
R6651 T23192 T23190 prep of,marker
R6652 T23193 T23192 pobj epithelia,of
R6653 T23194 T23195 punct (,blue
R6654 T23195 T23187 parataxis blue,Cdh1
R6655 T23196 T23195 punct ),blue
R6656 T23197 T23187 punct ", ",Cdh1
R6657 T23198 T23187 cc and,Cdh1
R6658 T23199 T23200 compound DBA,lectin
R6659 T23200 T23187 conj lectin,Cdh1
R6660 T23201 T23200 acl staining,lectin
R6661 T23202 T23203 det the,tree
R6662 T23203 T23201 dobj tree,staining
R6663 T23204 T23203 amod ureteric,tree
R6664 T23205 T23206 punct [,16
R6665 T23206 T23201 parataxis 16,staining
R6666 T23207 T23206 punct ],16
R6667 T23208 T23130 punct .,stained
R6668 T23210 T23211 amod Confocal,sections
R6669 T23211 T23214 nsubjpass sections,obtained
R6670 T23212 T23211 compound Z,sections
R6671 T23213 T23211 punct -,sections
R6672 T23215 T23214 auxpass were,obtained
R6673 T23216 T23217 det every,μm
R6674 T23217 T23214 dobj μm,obtained
R6675 T23218 T23217 nummod 5,μm
R6676 T23219 T23214 prep for,obtained
R6677 T23220 T23221 quantmod 75,80
R6678 T23221 T23223 nummod 80,μm
R6679 T23222 T23221 punct –,80
R6680 T23223 T23219 pobj μm,for
R6681 T23224 T23214 punct .,obtained
R6682 T23226 T23227 det A,number
R6683 T23227 T23229 nsubjpass number,observed
R6684 T23228 T23227 amod reduced,number
R6685 T23230 T23227 prep of,number
R6686 T23231 T23232 amod ureteric,tips
R6687 T23232 T23230 pobj tips,of
R6688 T23233 T23232 prep per,tips
R6689 T23234 T23233 pobj area,per
R6690 T23235 T23229 auxpass was,observed
R6691 T23236 T23229 prep in,observed
R6692 T23237 T23238 punct (,D
R6693 T23238 T23241 parataxis D,kidneys
R6694 T23239 T23238 nmod B,D
R6695 T23240 T23238 punct ", ",D
R6696 T23241 T23236 pobj kidneys,in
R6697 T23242 T23238 punct ),D
R6698 T23243 T23241 det the,kidneys
R6699 T23244 T23245 compound Pygo1,Pygo2
R6700 T23245 T23247 npadvmod Pygo2,null
R6701 T23246 T23245 punct /,Pygo2
R6702 T23247 T23241 amod null,kidneys
R6703 T23248 T23229 prep compared,observed
R6704 T23249 T23248 prep with,compared
R6705 T23250 T23251 punct (,C
R6706 T23251 T23254 parataxis C,littermates
R6707 T23252 T23251 nmod A,C
R6708 T23253 T23251 punct ", ",C
R6709 T23254 T23249 pobj littermates,with
R6710 T23255 T23251 punct ),C
R6711 T23256 T23254 compound control,littermates
R6712 T23257 T23229 punct .,observed
R6713 T23259 T23260 prep In,were
R6714 T23261 T23259 pobj addition,In
R6715 T23262 T23260 punct ", ",were
R6716 T23263 T23264 amod ureteric,bud
R6717 T23264 T23265 compound bud,tips
R6718 T23265 T23260 nsubj tips,were
R6719 T23266 T23260 advmod often,were
R6720 T23267 T23268 advmod more,dilated
R6721 T23268 T23260 acomp dilated,were
R6722 T23269 T23260 prep in,were
R6723 T23270 T23271 npadvmod Pygo1,null
R6724 T23271 T23274 amod null,mutants
R6725 T23272 T23270 punct /,Pygo1
R6726 T23273 T23270 nummod 2,Pygo1
R6727 T23274 T23269 pobj mutants,in
R6728 T23275 T23260 prep compared,were
R6729 T23276 T23275 prep with,compared
R6730 T23277 T23276 pobj controls,with
R6731 T23278 T23260 punct .,were
R6732 T23280 T23281 det The,mesenchyme
R6733 T23281 T23283 nsubjpass mesenchyme,expanded
R6734 T23282 T23281 amod condensed,mesenchyme
R6735 T23284 T23281 acl surrounding,mesenchyme
R6736 T23285 T23286 det the,bud
R6737 T23286 T23284 dobj bud,surrounding
R6738 T23287 T23286 amod ureteric,bud
R6739 T23288 T23283 auxpass was,expanded
R6740 T23289 T23283 advmod also,expanded
R6741 T23290 T23283 advmod significantly,expanded
R6742 T23291 T23283 prep in,expanded
R6743 T23292 T23293 det the,mutants
R6744 T23293 T23291 pobj mutants,in
R6745 T23294 T23283 punct .,expanded
R6746 T23296 T23297 amod Original,magnification
R6747 T23297 T23298 dep magnification,200
R6748 T23299 T23298 punct ×,200
R6749 T23300 T23298 punct .,200
R6750 T23567 T23566 prep of,Expression
R6751 T23568 T23567 pobj Wnt7b,of
R6752 T23569 T23568 punct ", ",Wnt7b
R6753 T23570 T23568 conj Wnt9b,Wnt7b
R6754 T23571 T23570 punct ", ",Wnt9b
R6755 T23572 T23570 cc and,Wnt9b
R6756 T23573 T23570 conj Wnt11,Wnt9b
R6757 T23574 T23566 prep in,Expression
R6758 T23575 T23576 nmod E18.5,kidneys
R6759 T23576 T23574 pobj kidneys,in
R6760 T23577 T23578 compound Pygo1,Pygo2
R6761 T23578 T23580 npadvmod Pygo2,null
R6762 T23579 T23578 punct /,Pygo2
R6763 T23580 T23576 amod null,kidneys
R6764 T23581 T23580 npadvmod compound,null
R6765 T23582 T23566 punct .,Expression
R6766 T23584 T23585 amod Whole,mount
R6767 T23586 T23585 punct -,mount
R6768 T23587 T23585 nmod in,mount
R6769 T23588 T23585 nmod situ,mount
R6770 T23589 T23585 prep of,mount
R6771 T23590 T23589 pobj hybridizations,of
R6772 T23591 T23590 prep of,hybridizations
R6773 T23592 T23593 punct (,A
R6774 T23593 T23594 parataxis A,kidneys
R6775 T23594 T23591 pobj kidneys,of
R6776 T23595 T23596 punct -,C
R6777 T23596 T23593 prep C,A
R6778 T23597 T23593 punct ),A
R6779 T23598 T23594 nmod E18.5,kidneys
R6780 T23599 T23600 amod wild,type
R6781 T23600 T23594 compound type,kidneys
R6782 T23601 T23600 punct -,type
R6783 T23602 T23594 cc and,kidneys
R6784 T23603 T23604 punct (,D
R6785 T23604 T23605 parataxis D,kidneys
R6786 T23605 T23594 conj kidneys,kidneys
R6787 T23606 T23607 punct -,F
R6788 T23607 T23604 prep F,D
R6789 T23608 T23604 punct ),D
R6790 T23609 T23610 nmod Pygo1,mutant
R6791 T23610 T23605 compound mutant,kidneys
R6792 T23611 T23609 punct -,Pygo1
R6793 T23612 T23609 punct /,Pygo1
R6794 T23613 T23609 punct -,Pygo1
R6795 T23614 T23609 punct /,Pygo1
R6796 T23615 T23609 appos Pygo2,Pygo1
R6797 T23616 T23615 punct -,Pygo2
R6798 T23617 T23615 punct /,Pygo2
R6799 T23618 T23615 punct -,Pygo2
R6800 T23619 T23590 prep with,hybridizations
R6801 T23620 T23621 det the,markers
R6802 T23621 T23619 pobj markers,with
R6803 T23622 T23623 amod ureteric,bud
R6804 T23623 T23624 npadvmod bud,derivative
R6805 T23624 T23621 amod derivative,markers
R6806 T23625 T23621 punct : ,markers
R6807 T23626 T23627 punct (,D
R6808 T23627 T23630 parataxis D,Wnt7b
R6809 T23628 T23627 nmod A,D
R6810 T23629 T23627 punct ", ",D
R6811 T23630 T23621 appos Wnt7b,markers
R6812 T23631 T23627 punct ),D
R6813 T23632 T23630 punct ", ",Wnt7b
R6814 T23633 T23634 punct (,E
R6815 T23634 T23637 parataxis E,Wnt9b
R6816 T23635 T23634 nmod B,E
R6817 T23636 T23634 punct ", ",E
R6818 T23637 T23630 conj Wnt9b,Wnt7b
R6819 T23638 T23634 punct ),E
R6820 T23639 T23637 punct ", ",Wnt9b
R6821 T23640 T23637 cc and,Wnt9b
R6822 T23641 T23642 punct (,F
R6823 T23642 T23645 parataxis F,Wnt11
R6824 T23643 T23642 nmod C,F
R6825 T23644 T23642 punct ", ",F
R6826 T23645 T23637 conj Wnt11,Wnt9b
R6827 T23646 T23642 punct ),F
R6828 T23647 T23585 punct .,mount
R6829 T23649 T23650 det The,kidneys
R6830 T23650 T23652 nsubj kidneys,showed
R6831 T23651 T23650 compound mutant,kidneys
R6832 T23653 T23654 amod normal,patterns
R6833 T23654 T23652 dobj patterns,showed
R6834 T23655 T23654 compound expression,patterns
R6835 T23656 T23654 prep for,patterns
R6836 T23657 T23658 det the,markers
R6837 T23658 T23656 pobj markers,for
R6838 T23659 T23660 amod ureteric,stalk
R6839 T23660 T23658 compound stalk,markers
R6840 T23661 T23658 appos Wnt7b,markers
R6841 T23662 T23661 cc and,Wnt7b
R6842 T23663 T23661 conj Wnt9b,Wnt7b
R6843 T23664 T23654 punct ", ",patterns
R6844 T23665 T23654 cc and,patterns
R6845 T23666 T23667 amod reduced,density
R6846 T23667 T23654 conj density,patterns
R6847 T23668 T23667 prep of,density
R6848 T23669 T23670 amod ureteric,tips
R6849 T23670 T23668 pobj tips,of
R6850 T23671 T23672 mark as,measured
R6851 T23672 T23652 advcl measured,showed
R6852 T23673 T23672 agent by,measured
R6853 T23674 T23673 pobj Wnt11,by
R6854 T23675 T23652 punct .,showed
R6855 T23677 T23678 amod Original,magnification
R6856 T23678 T23679 dep magnification,32
R6857 T23680 T23679 punct ×,32
R6858 T23681 T23679 punct .,32
R6861 T24238 T24239 amod Reduced,signaling
R6862 T24240 T24239 amod canonical,signaling
R6863 T24241 T24239 compound Wnt,signaling
R6864 T24242 T24239 prep in,signaling
R6865 T24243 T24244 nmod Pygo2,mutant
R6866 T24244 T24249 compound mutant,embryos
R6867 T24245 T24243 cc and,Pygo2
R6868 T24246 T24247 compound Pygo1,Pygo2
R6869 T24247 T24243 conj Pygo2,Pygo2
R6870 T24248 T24247 punct /,Pygo2
R6871 T24249 T24242 pobj embryos,in
R6872 T24250 T24239 punct .,signaling
R6873 T24252 T24253 compound E10.5,embryos
R6874 T24254 T24253 punct ", ",embryos
R6875 T24255 T24253 appos all,embryos
R6876 T24256 T24255 prep with,all
R6877 T24257 T24258 det the,reporter
R6878 T24258 T24256 pobj reporter,with
R6879 T24259 T24260 compound BAT,gal
R6880 T24260 T24262 compound gal,transgene
R6881 T24261 T24260 punct -,gal
R6882 T24262 T24258 compound transgene,reporter
R6883 T24263 T24258 prep of,reporter
R6884 T24264 T24265 amod canonical,signaling
R6885 T24265 T24263 pobj signaling,of
R6886 T24266 T24265 compound Wnt,signaling
R6887 T24267 T24253 punct .,embryos
R6888 T24269 T24270 punct (,A
R6889 T24270 T24271 meta A,showed
R6890 T24272 T24270 punct ),A
R6891 T24273 T24274 nmod Pygo1,embryos
R6892 T24274 T24271 nsubj embryos,showed
R6893 T24275 T24273 punct +,Pygo1
R6894 T24276 T24273 punct /,Pygo1
R6895 T24277 T24273 punct +,Pygo1
R6896 T24278 T24273 punct /,Pygo1
R6897 T24279 T24273 appos Pygo2,Pygo1
R6898 T24280 T24279 punct +,Pygo2
R6899 T24281 T24279 punct /,Pygo2
R6900 T24282 T24279 punct -,Pygo2
R6901 T24283 T24284 amod normal,staining
R6902 T24284 T24271 dobj staining,showed
R6903 T24285 T24286 compound X,gal
R6904 T24286 T24284 compound gal,staining
R6905 T24287 T24286 punct -,gal
R6906 T24288 T24271 prep in,showed
R6907 T24289 T24290 det the,brain
R6908 T24290 T24288 pobj brain,in
R6909 T24291 T24290 amod developing,brain
R6910 T24292 T24290 punct ", ",brain
R6911 T24293 T24294 amod pharyngeal,pouches
R6912 T24294 T24290 appos pouches,brain
R6913 T24295 T24290 punct ", ",brain
R6914 T24296 T24297 amod otic,vesicle
R6915 T24297 T24290 appos vesicle,brain
R6916 T24298 T24290 punct ", ",brain
R6917 T24299 T24300 amod apical,ridges
R6918 T24300 T24290 appos ridges,brain
R6919 T24301 T24300 amod ectodermal,ridges
R6920 T24302 T24300 prep of,ridges
R6921 T24303 T24304 det the,buds
R6922 T24304 T24302 pobj buds,of
R6923 T24305 T24306 amod fore,limb
R6924 T24306 T24304 compound limb,buds
R6925 T24307 T24305 cc and,fore
R6926 T24308 T24305 conj hind,fore
R6927 T24309 T24288 punct ", ",in
R6928 T24310 T24288 cc and,in
R6929 T24311 T24288 conj in,in
R6930 T24312 T24311 pobj somites,in
R6931 T24313 T24271 punct .,showed
R6932 T24315 T24316 punct (,B
R6933 T24316 T24317 meta B,showed
R6934 T24318 T24316 punct ),B
R6935 T24319 T24320 nmod Pygo1,embryos
R6936 T24320 T24317 nsubj embryos,showed
R6937 T24321 T24319 punct +,Pygo1
R6938 T24322 T24319 punct /,Pygo1
R6939 T24323 T24319 punct -,Pygo1
R6940 T24324 T24319 punct /,Pygo1
R6941 T24325 T24319 appos Pygo2,Pygo1
R6942 T24326 T24325 punct -,Pygo2
R6943 T24327 T24325 punct /,Pygo2
R6944 T24328 T24325 punct -,Pygo2
R6945 T24329 T24320 punct ", ",embryos
R6946 T24330 T24320 prep with,embryos
R6947 T24331 T24330 pobj loss,with
R6948 T24332 T24331 prep of,loss
R6949 T24333 T24334 det both,alleles
R6950 T24334 T24332 pobj alleles,of
R6951 T24335 T24334 compound Pygo2,alleles
R6952 T24336 T24317 punct ", ",showed
R6953 T24337 T24338 amod reduced,reporter
R6954 T24338 T24345 compound reporter,expression
R6955 T24339 T24337 cc but,reduced
R6956 T24340 T24339 neg not,but
R6957 T24341 T24337 conj absent,reduced
R6958 T24342 T24343 compound BAT,gal
R6959 T24343 T24338 compound gal,reporter
R6960 T24344 T24343 punct -,gal
R6961 T24345 T24317 dobj expression,showed
R6962 T24346 T24317 prep in,showed
R6963 T24347 T24348 amod many,structures
R6964 T24348 T24346 pobj structures,in
R6965 T24349 T24348 amod developing,structures
R6966 T24350 T24348 punct ", ",structures
R6967 T24351 T24348 prep including,structures
R6968 T24352 T24353 amod pharyngeal,pouches
R6969 T24353 T24351 pobj pouches,including
R6970 T24354 T24353 punct ", ",pouches
R6971 T24355 T24356 amod otic,vesicle
R6972 T24356 T24353 conj vesicle,pouches
R6973 T24357 T24356 punct ", ",vesicle
R6974 T24358 T24356 cc and,vesicle
R6975 T24359 T24356 conj somites,vesicle
R6976 T24360 T24317 punct .,showed
R6977 T24362 T24363 punct (,C
R6978 T24363 T24364 meta C,showed
R6979 T24365 T24363 punct ),C
R6980 T24366 T24367 nmod Pygo1,embryo
R6981 T24367 T24364 nsubj embryo,showed
R6982 T24368 T24366 punct -,Pygo1
R6983 T24369 T24366 punct /,Pygo1
R6984 T24370 T24366 punct -,Pygo1
R6985 T24371 T24366 punct /,Pygo1
R6986 T24372 T24366 appos Pygo2,Pygo1
R6987 T24373 T24372 punct +,Pygo2
R6988 T24374 T24372 punct /,Pygo2
R6989 T24375 T24372 punct -,Pygo2
R6990 T24376 T24367 punct ", ",embryo
R6991 T24377 T24367 prep with,embryo
R6992 T24378 T24377 pobj mutation,with
R6993 T24379 T24378 prep of,mutation
R6994 T24380 T24381 det both,alleles
R6995 T24381 T24379 pobj alleles,of
R6996 T24382 T24381 compound Pygo1,alleles
R6997 T24383 T24381 punct ", ",alleles
R6998 T24384 T24381 cc but,alleles
R6999 T24385 T24386 nummod one,allele
R7000 T24386 T24381 conj allele,alleles
R7001 T24387 T24388 amod wild,type
R7002 T24388 T24386 compound type,allele
R7003 T24389 T24388 punct -,type
R7004 T24390 T24386 compound Pygo2,allele
R7005 T24391 T24364 punct ", ",showed
R7006 T24392 T24393 amod normal,expression
R7007 T24393 T24364 dobj expression,showed
R7008 T24394 T24395 compound BAT,gal
R7009 T24395 T24393 compound gal,expression
R7010 T24396 T24395 punct -,gal
R7011 T24397 T24364 punct .,showed
R7012 T24399 T24400 punct (,D
R7013 T24400 T24401 meta D,showed
R7014 T24402 T24400 punct ),D
R7015 T24403 T24404 amod Double,homozygous
R7016 T24404 T24406 amod homozygous,embryos
R7017 T24405 T24404 punct -,homozygous
R7018 T24406 T24401 nsubj embryos,showed
R7019 T24407 T24406 nmod mutant,embryos
R7020 T24408 T24406 nmod Pygo1,embryos
R7021 T24409 T24408 punct -,Pygo1
R7022 T24410 T24408 punct /,Pygo1
R7023 T24411 T24408 punct -,Pygo1
R7024 T24412 T24408 punct /,Pygo1
R7025 T24413 T24408 appos Pygo2,Pygo1
R7026 T24414 T24413 punct -,Pygo2
R7027 T24415 T24413 punct /,Pygo2
R7028 T24416 T24413 punct -,Pygo2
R7029 T24417 T24401 advmod still,showed
R7030 T24418 T24419 det some,expression
R7031 T24419 T24401 dobj expression,showed
R7032 T24420 T24419 amod remaining,expression
R7033 T24421 T24422 compound BAT,gal
R7034 T24422 T24419 compound gal,expression
R7035 T24423 T24422 punct -,gal
R7036 T24424 T24401 punct ", ",showed
R7037 T24425 T24401 advcl suggesting,showed
R7038 T24426 T24427 amod residual,signaling
R7039 T24427 T24425 dobj signaling,suggesting
R7040 T24428 T24427 amod canonical,signaling
R7041 T24429 T24427 compound Wnt,signaling
R7042 T24430 T24401 punct .,showed
R7043 T24432 T24433 nsubj Embryos,were
R7044 T24434 T24432 prep in,Embryos
R7045 T24435 T24436 nmod panels,A
R7046 T24436 T24434 pobj A,in
R7047 T24437 T24436 punct (,A
R7048 T24438 T24436 punct ),A
R7049 T24439 T24436 cc and,A
R7050 T24440 T24441 punct (,B
R7051 T24441 T24436 conj B,A
R7052 T24442 T24433 punct ),were
R7053 T24443 T24433 prep from,were
R7054 T24444 T24445 det the,litter
R7055 T24445 T24443 pobj litter,from
R7056 T24446 T24445 amod same,litter
R7057 T24447 T24433 cc and,were
R7058 T24448 T24449 auxpass were,processed
R7059 T24449 T24433 conj processed,were
R7060 T24450 T24449 prep in,processed
R7061 T24451 T24450 pobj parallel,in
R7062 T24452 T24449 punct ", ",processed
R7063 T24453 T24454 mark while,were
R7064 T24454 T24449 advcl were,processed
R7065 T24455 T24454 nsubj embryos,were
R7066 T24456 T24455 prep in,embryos
R7067 T24457 T24456 punct (,in
R7068 T24458 T24456 pobj C,in
R7069 T24459 T24458 punct ),C
R7070 T24460 T24458 cc and,C
R7071 T24461 T24462 punct (,D
R7072 T24462 T24458 conj D,C
R7073 T24463 T24454 punct ),were
R7074 T24464 T24454 prep from,were
R7075 T24465 T24466 det a,litter
R7076 T24466 T24464 pobj litter,from
R7077 T24467 T24466 amod separate,litter
R7078 T24468 T24466 punct ", ",litter
R7079 T24469 T24470 advmod also,processed
R7080 T24470 T24466 acl processed,litter
R7081 T24471 T24470 prep in,processed
R7082 T24472 T24471 pobj parallel,in
R7083 T24473 T24454 punct ", ",were
R7084 T24474 T24454 cc and,were
R7085 T24475 T24454 conj were,were
R7086 T24476 T24477 advmod slightly,more
R7087 T24477 T24478 advmod more,advanced
R7088 T24478 T24475 acomp advanced,were
R7089 T24479 T24478 advmod developmentally,advanced
R7090 T24480 T24433 punct .,were
R7091 T24482 T24483 amod Original,magnification
R7092 T24483 T24484 dep magnification,20
R7093 T24485 T24486 punct (,B
R7094 T24486 T24484 parataxis B,20
R7095 T24487 T24486 nmod A,B
R7096 T24488 T24486 punct ", ",B
R7097 T24489 T24486 punct ),B
R7098 T24490 T24484 punct ×,20
R7099 T24491 T24484 punct ;,20
R7100 T24492 T24493 punct (,D
R7101 T24493 T24496 parataxis D,16
R7102 T24494 T24493 nmod C,D
R7103 T24495 T24493 punct ", ",D
R7104 T24496 T24484 appos 16,20
R7105 T24497 T24493 punct ),D
R7106 T24498 T24496 punct ×,16
R7107 T24499 T24484 punct .,20
R7108 T25934 T25935 nsubjpass Pygo2,required
R7109 T25936 T25935 auxpass is,required
R7110 T25937 T25935 prep for,required
R7111 T25938 T25939 compound BAT,gal
R7112 T25939 T25941 compound gal,reporter
R7113 T25940 T25939 punct -,gal
R7114 T25941 T25942 compound reporter,expression
R7115 T25942 T25937 pobj expression,for
R7116 T25943 T25935 prep in,required
R7117 T25944 T25945 amod ureteric,bud
R7118 T25945 T25946 npadvmod bud,derived
R7119 T25946 T25948 amod derived,structures
R7120 T25947 T25946 punct -,derived
R7121 T25948 T25943 pobj structures,in
R7122 T25949 T25948 prep of,structures
R7123 T25950 T25951 det the,kidney
R7124 T25951 T25949 pobj kidney,of
R7125 T25952 T25951 amod developing,kidney
R7126 T25953 T25935 punct .,required
R7127 T25955 T25956 compound X,Gal
R7128 T25956 T25958 compound Gal,staining
R7129 T25957 T25956 punct -,Gal
R7130 T25959 T25958 prep of,staining
R7131 T25960 T25961 compound BAT,gal
R7132 T25961 T25963 npadvmod gal,transgenic
R7133 T25962 T25961 punct -,gal
R7134 T25963 T25964 amod transgenic,tracts
R7135 T25964 T25959 pobj tracts,of
R7136 T25965 T25966 punct (,A
R7137 T25966 T25967 parataxis A,E10.5
R7138 T25967 T25964 nmod E10.5,tracts
R7139 T25968 T25969 punct -,C
R7140 T25969 T25966 prep C,A
R7141 T25970 T25966 punct ),A
R7142 T25971 T25967 punct ", ",E10.5
R7143 T25972 T25967 cc and,E10.5
R7144 T25973 T25974 punct (,E
R7145 T25974 T25975 parataxis E,E13.5
R7146 T25975 T25967 conj E13.5,E10.5
R7147 T25976 T25977 punct -,L
R7148 T25977 T25974 prep L,E
R7149 T25978 T25974 punct ),E
R7150 T25979 T25964 amod urogenital,tracts
R7151 T25980 T25964 punct ", ",tracts
R7152 T25981 T25964 cc and,tracts
R7153 T25982 T25983 punct (,M
R7154 T25983 T25984 parataxis M,kidneys
R7155 T25984 T25964 conj kidneys,tracts
R7156 T25985 T25986 punct -,O
R7157 T25986 T25983 prep O,M
R7158 T25987 T25983 punct ),M
R7159 T25988 T25984 compound E18.5,kidneys
R7160 T25989 T25958 punct .,staining
R7161 T25991 T25992 punct (,A
R7162 T25992 T25993 meta A,Pygo1
R7163 T25994 T25992 punct ),A
R7164 T25995 T25993 punct -,Pygo1
R7165 T25996 T25993 punct /,Pygo1
R7166 T25997 T25993 punct -,Pygo1
R7167 T25998 T25993 punct /,Pygo1
R7168 T25999 T25993 appos Pygo2,Pygo1
R7169 T26000 T25999 punct +,Pygo2
R7170 T26001 T25999 punct /,Pygo2
R7171 T26002 T25999 punct +,Pygo2
R7172 T26003 T26004 punct (,left
R7173 T26004 T25993 parataxis left,Pygo1
R7174 T26005 T26004 punct ),left
R7175 T26006 T25993 cc and,Pygo1
R7176 T26007 T25993 conj Pygo1,Pygo1
R7177 T26008 T26007 punct +,Pygo1
R7178 T26009 T26007 punct /,Pygo1
R7179 T26010 T26007 punct -,Pygo1
R7180 T26011 T26007 punct /,Pygo1
R7181 T26012 T26007 appos Pygo2,Pygo1
R7182 T26013 T26012 punct -,Pygo2
R7183 T26014 T26012 punct /,Pygo2
R7184 T26015 T26012 punct -,Pygo2
R7185 T26016 T26017 punct (,right
R7186 T26017 T26007 parataxis right,Pygo1
R7187 T26018 T26017 punct ),right
R7188 T26019 T26007 punct .,Pygo1
R7189 T26022 T26023 det the,loss
R7190 T26023 T26021 dobj loss,Note
R7191 T26024 T26023 prep of,loss
R7192 T26025 T26026 compound reporter,activity
R7193 T26026 T26024 pobj activity,of
R7194 T26027 T26023 prep in,loss
R7195 T26028 T26029 det the,duct
R7196 T26029 T26027 pobj duct,in
R7197 T26030 T26029 amod nephric,duct
R7198 T26031 T26032 punct (,arrowhead
R7199 T26032 T26023 parataxis arrowhead,loss
R7200 T26033 T26032 amod black,arrowhead
R7201 T26034 T26032 punct ),arrowhead
R7202 T26035 T26023 cc and,loss
R7203 T26036 T26023 conj reduction,loss
R7204 T26037 T26036 prep of,reduction
R7205 T26038 T26037 pobj staining,of
R7206 T26039 T26036 prep in,reduction
R7207 T26040 T26041 det the,bud
R7208 T26041 T26039 pobj bud,in
R7209 T26042 T26041 amod ureteric,bud
R7210 T26043 T26044 punct (,arrow
R7211 T26044 T26041 parataxis arrow,bud
R7212 T26045 T26044 amod white,arrow
R7213 T26046 T26044 punct ),arrow
R7214 T26047 T26041 prep of,bud
R7215 T26048 T26049 det the,embryo
R7216 T26049 T26047 pobj embryo,of
R7217 T26050 T26051 npadvmod Pygo2,null
R7218 T26051 T26049 amod null,embryo
R7219 T26052 T26053 punct (,Right
R7220 T26053 T26036 parataxis Right,reduction
R7221 T26054 T26053 punct ),Right
R7222 T26055 T26021 punct .,Note
R7223 T26057 T26058 punct (,B
R7224 T26058 T26059 meta B,embryo
R7225 T26060 T26058 punct ),B
R7226 T26061 T26059 nmod Pygo1,embryo
R7227 T26062 T26061 punct -,Pygo1
R7228 T26063 T26061 punct /,Pygo1
R7229 T26064 T26061 punct -,Pygo1
R7230 T26065 T26061 punct /,Pygo1
R7231 T26066 T26061 appos Pygo2,Pygo1
R7232 T26067 T26066 punct +,Pygo2
R7233 T26068 T26066 punct /,Pygo2
R7234 T26069 T26066 punct -,Pygo2
R7235 T26070 T26059 compound E10.5,embryo
R7236 T26071 T26059 prep with,embryo
R7237 T26072 T26073 compound BAT,gal
R7238 T26073 T26075 compound gal,reporter
R7239 T26074 T26073 punct -,gal
R7240 T26075 T26076 compound reporter,activity
R7241 T26076 T26071 pobj activity,with
R7242 T26077 T26076 prep in,activity
R7243 T26078 T26079 det the,duct
R7244 T26079 T26077 pobj duct,in
R7245 T26080 T26079 amod nephric,duct
R7246 T26081 T26082 punct (,arrowhead
R7247 T26082 T26079 parataxis arrowhead,duct
R7248 T26083 T26082 amod black,arrowhead
R7249 T26084 T26082 punct ),arrowhead
R7250 T26085 T26079 cc and,duct
R7251 T26086 T26087 amod ureteric,bud
R7252 T26087 T26079 conj bud,duct
R7253 T26088 T26089 punct (,arrow
R7254 T26089 T26087 parataxis arrow,bud
R7255 T26090 T26089 amod white,arrow
R7256 T26091 T26089 punct ),arrow
R7257 T26092 T26059 punct .,embryo
R7258 T26094 T26095 punct (,C
R7259 T26095 T26096 meta C,embryo
R7260 T26097 T26095 punct ),C
R7261 T26098 T26096 nmod Pygo1,embryo
R7262 T26099 T26098 punct -,Pygo1
R7263 T26100 T26098 punct /,Pygo1
R7264 T26101 T26098 punct -,Pygo1
R7265 T26102 T26098 punct /,Pygo1
R7266 T26103 T26098 appos Pygo,Pygo1
R7267 T26104 T26103 punct -,Pygo
R7268 T26105 T26103 punct /,Pygo
R7269 T26106 T26103 punct -,Pygo
R7270 T26107 T26096 punct ", ",embryo
R7271 T26108 T26109 mark with,lost
R7272 T26109 T26096 advcl lost,embryo
R7273 T26110 T26111 compound reporter,expression
R7274 T26111 T26109 nsubj expression,lost
R7275 T26112 T26109 prep in,lost
R7276 T26113 T26114 det the,duct
R7277 T26114 T26112 pobj duct,in
R7278 T26115 T26114 amod nephric,duct
R7279 T26116 T26109 cc and,lost
R7280 T26117 T26109 conj reduced,lost
R7281 T26118 T26117 prep in,reduced
R7282 T26119 T26120 det the,bud
R7283 T26120 T26118 pobj bud,in
R7284 T26121 T26120 amod ureteric,bud
R7285 T26122 T26123 punct (,arrow
R7286 T26123 T26109 parataxis arrow,lost
R7287 T26124 T26123 amod white,arrow
R7288 T26125 T26123 punct ),arrow
R7289 T26126 T26096 punct .,embryo
R7290 T26128 T26129 punct (,D
R7291 T26129 T26130 meta D,staining
R7292 T26131 T26129 punct ),D
R7293 T26132 T26130 compound Control,staining
R7294 T26133 T26130 compound background,staining
R7295 T26134 T26135 compound X,gal
R7296 T26135 T26130 compound gal,staining
R7297 T26136 T26135 punct -,gal
R7298 T26137 T26130 prep of,staining
R7299 T26138 T26139 det a,tract
R7300 T26139 T26137 pobj tract,of
R7301 T26140 T26139 amod urogenital,tract
R7302 T26141 T26139 prep from,tract
R7303 T26142 T26143 det an,embryo
R7304 T26143 T26141 pobj embryo,from
R7305 T26144 T26143 compound E13.5,embryo
R7306 T26145 T26143 prep without,embryo
R7307 T26146 T26147 det the,transgene
R7308 T26147 T26145 pobj transgene,without
R7309 T26148 T26149 compound BAT,gal
R7310 T26149 T26147 compound gal,transgene
R7311 T26150 T26149 punct -,gal
R7312 T26151 T26139 punct (,tract
R7313 T26152 T26139 appos Non-Tg,tract
R7314 T26153 T26139 punct ),tract
R7315 T26154 T26139 punct ", ",tract
R7316 T26155 T26139 acl showing,tract
R7317 T26156 T26155 dobj absence,showing
R7318 T26157 T26156 prep of,absence
R7319 T26158 T26159 amod endogenous,activity
R7320 T26159 T26157 pobj activity,of
R7321 T26160 T26161 compound beta,galactosidase
R7322 T26161 T26159 compound galactosidase,activity
R7323 T26162 T26161 punct -,galactosidase
R7324 T26163 T26130 punct .,staining
R7325 T26165 T26166 punct (,E
R7326 T26166 T26167 meta E,Pygo1
R7327 T26168 T26166 punct ),E
R7328 T26169 T26167 punct +,Pygo1
R7329 T26170 T26167 punct /,Pygo1
R7330 T26171 T26167 punct -,Pygo1
R7331 T26172 T26167 punct /,Pygo1
R7332 T26173 T26167 appos Pygo2,Pygo1
R7333 T26174 T26173 punct +,Pygo2
R7334 T26175 T26173 punct /,Pygo2
R7335 T26176 T26173 punct +,Pygo2
R7336 T26177 T26167 punct ", ",Pygo1
R7337 T26178 T26167 prep with,Pygo1
R7338 T26179 T26180 compound BAT,gal
R7339 T26180 T26182 compound gal,reporter
R7340 T26181 T26180 punct -,gal
R7341 T26182 T26183 compound reporter,activity
R7342 T26183 T26178 pobj activity,with
R7343 T26184 T26167 prep in,Pygo1
R7344 T26185 T26186 det the,compartment
R7345 T26186 T26184 pobj compartment,in
R7346 T26187 T26186 amod ureteric,compartment
R7347 T26188 T26186 prep of,compartment
R7348 T26189 T26190 det the,kidney
R7349 T26190 T26188 pobj kidney,of
R7350 T26191 T26190 amod developing,kidney
R7351 T26192 T26186 punct ", ",compartment
R7352 T26193 T26186 prep including,compartment
R7353 T26194 T26195 det the,tips
R7354 T26195 T26193 pobj tips,including
R7355 T26196 T26195 amod ureteric,tips
R7356 T26197 T26195 punct ", ",tips
R7357 T26198 T26199 amod ureteric,tree
R7358 T26199 T26195 conj tree,tips
R7359 T26200 T26199 punct ", ",tree
R7360 T26201 T26199 cc and,tree
R7361 T26202 T26199 conj ureter,tree
R7362 T26203 T26167 punct .,Pygo1
R7363 T26205 T26206 punct (,F
R7364 T26206 T26207 meta F,Pygo1
R7365 T26208 T26206 punct ),F
R7366 T26209 T26207 punct +,Pygo1
R7367 T26210 T26207 punct /,Pygo1
R7368 T26211 T26207 punct -,Pygo1
R7369 T26212 T26207 punct /,Pygo1
R7370 T26213 T26207 appos Pygo2,Pygo1
R7371 T26214 T26213 punct -,Pygo2
R7372 T26215 T26213 punct /,Pygo2
R7373 T26216 T26213 punct -,Pygo2
R7374 T26217 T26207 punct ", ",Pygo1
R7375 T26218 T26207 prep with,Pygo1
R7376 T26219 T26220 amod marked,reduction
R7377 T26220 T26218 pobj reduction,with
R7378 T26221 T26220 prep of,reduction
R7379 T26222 T26223 compound BAT,gal
R7380 T26223 T26225 compound gal,reporter
R7381 T26224 T26223 punct -,gal
R7382 T26225 T26226 compound reporter,activity
R7383 T26226 T26221 pobj activity,of
R7384 T26227 T26220 prep in,reduction
R7385 T26228 T26229 det the,compartment
R7386 T26229 T26227 pobj compartment,in
R7387 T26230 T26229 amod ureteric,compartment
R7388 T26231 T26207 punct .,Pygo1
R7389 T26233 T26234 punct (,G
R7390 T26234 T26235 meta G,Pygo1
R7391 T26236 T26234 punct ),G
R7392 T26237 T26235 punct +,Pygo1
R7393 T26238 T26235 punct /,Pygo1
R7394 T26239 T26235 punct -,Pygo1
R7395 T26240 T26235 punct /,Pygo1
R7396 T26241 T26235 appos Pygo2,Pygo1
R7397 T26242 T26241 punct +,Pygo2
R7398 T26243 T26241 punct /,Pygo2
R7399 T26244 T26241 punct -,Pygo2
R7400 T26245 T26235 punct ", ",Pygo1
R7401 T26246 T26235 prep with,Pygo1
R7402 T26247 T26248 compound reporter,expression
R7403 T26248 T26246 pobj expression,with
R7404 T26249 T26248 prep in,expression
R7405 T26250 T26251 det the,duct
R7406 T26251 T26249 pobj duct,in
R7407 T26252 T26251 amod paramesonephric,duct
R7408 T26253 T26254 punct (,arrowhead
R7409 T26254 T26251 parataxis arrowhead,duct
R7410 T26255 T26254 amod white,arrowhead
R7411 T26256 T26254 punct ),arrowhead
R7412 T26257 T26251 cc and,duct
R7413 T26258 T26259 amod ureteric,tree
R7414 T26259 T26251 conj tree,duct
R7415 T26260 T26235 punct .,Pygo1
R7416 T26262 T26263 punct (,H
R7417 T26263 T26264 meta H,Pygo1
R7418 T26265 T26263 punct ", ",H
R7419 T26266 T26263 dep I,H
R7420 T26267 T26263 punct ),H
R7421 T26268 T26264 punct -,Pygo1
R7422 T26269 T26264 punct /,Pygo1
R7423 T26270 T26264 punct -,Pygo1
R7424 T26271 T26264 punct /,Pygo1
R7425 T26272 T26264 appos Pygo2,Pygo1
R7426 T26273 T26272 punct +,Pygo2
R7427 T26274 T26272 punct /,Pygo2
R7428 T26275 T26272 punct -,Pygo2
R7429 T26276 T26264 punct ", ",Pygo1
R7430 T26277 T26264 prep with,Pygo1
R7431 T26278 T26279 punct (,H
R7432 T26279 T26280 meta H,view
R7433 T26280 T26277 pobj view,with
R7434 T26281 T26279 punct ),H
R7435 T26282 T26280 amod ventral,view
R7436 T26283 T26280 acl showing,view
R7437 T26284 T26285 compound reporter,expression
R7438 T26285 T26283 dobj expression,showing
R7439 T26286 T26283 prep in,showing
R7440 T26287 T26288 det the,duct
R7441 T26288 T26286 pobj duct,in
R7442 T26289 T26288 amod paramesonephric,duct
R7443 T26290 T26291 punct (,arrowhead
R7444 T26291 T26283 parataxis arrowhead,showing
R7445 T26292 T26291 amod white,arrowhead
R7446 T26293 T26291 punct ),arrowhead
R7447 T26294 T26280 punct ", ",view
R7448 T26295 T26280 cc and,view
R7449 T26296 T26297 punct (,I
R7450 T26297 T26298 meta I,view
R7451 T26298 T26280 conj view,view
R7452 T26299 T26297 punct ),I
R7453 T26300 T26298 amod dorsal,view
R7454 T26301 T26298 acl showing,view
R7455 T26302 T26303 amod ureteric,tree
R7456 T26303 T26304 compound tree,expression
R7457 T26304 T26301 dobj expression,showing
R7458 T26305 T26301 prep in,showing
R7459 T26306 T26307 det the,kidney
R7460 T26307 T26305 pobj kidney,in
R7461 T26308 T26264 punct .,Pygo1
R7462 T26310 T26311 punct (,J
R7463 T26311 T26312 meta J,Pygo1
R7464 T26313 T26311 punct ),J
R7465 T26314 T26312 punct +,Pygo1
R7466 T26315 T26312 punct /,Pygo1
R7467 T26316 T26312 punct -,Pygo1
R7468 T26317 T26312 punct /,Pygo1
R7469 T26318 T26312 appos Pygo2,Pygo1
R7470 T26319 T26318 punct +,Pygo2
R7471 T26320 T26318 punct /,Pygo2
R7472 T26321 T26318 punct -,Pygo2
R7473 T26322 T26312 punct ", ",Pygo1
R7474 T26323 T26324 det a,control
R7475 T26324 T26312 appos control,Pygo1
R7476 T26325 T26324 acl processed,control
R7477 T26326 T26325 prep in,processed
R7478 T26327 T26326 pobj parallel,in
R7479 T26328 T26325 prep with,processed
R7480 T26329 T26328 punct (,with
R7481 T26330 T26328 pobj K,with
R7482 T26331 T26330 punct ),K
R7483 T26332 T26330 cc and,K
R7484 T26333 T26334 punct (,L
R7485 T26334 T26330 conj L,K
R7486 T26335 T26312 punct ),Pygo1
R7487 T26336 T26312 punct ", ",Pygo1
R7488 T26337 T26312 prep with,Pygo1
R7489 T26338 T26337 pobj expression,with
R7490 T26339 T26338 prep in,expression
R7491 T26340 T26341 amod ureteric,tree
R7492 T26341 T26339 pobj tree,in
R7493 T26342 T26341 cc and,tree
R7494 T26343 T26344 amod paramesonephric,duct
R7495 T26344 T26341 conj duct,tree
R7496 T26345 T26312 punct .,Pygo1
R7497 T26347 T26348 punct (,K
R7498 T26348 T26349 meta K,lost
R7499 T26350 T26348 punct ", ",K
R7500 T26351 T26348 dep L,K
R7501 T26352 T26348 punct ),K
R7502 T26353 T26354 nmod Pygo1,reporter
R7503 T26354 T26364 compound reporter,activity
R7504 T26355 T26353 punct -,Pygo1
R7505 T26356 T26353 punct /,Pygo1
R7506 T26357 T26353 punct -,Pygo1
R7507 T26358 T26353 punct /,Pygo1
R7508 T26359 T26353 appos Pygo2,Pygo1
R7509 T26360 T26359 punct -,Pygo2
R7510 T26361 T26359 punct /,Pygo2
R7511 T26362 T26359 punct -,Pygo2
R7512 T26363 T26354 punct ", ",reporter
R7513 T26364 T26349 nsubjpass activity,lost
R7514 T26365 T26349 auxpass was,lost
R7515 T26366 T26349 prep in,lost
R7516 T26367 T26368 det the,duct
R7517 T26368 T26366 pobj duct,in
R7518 T26369 T26368 amod paramesonephric,duct
R7519 T26370 T26371 punct (,arrowhead
R7520 T26371 T26368 parataxis arrowhead,duct
R7521 T26372 T26371 amod white,arrowhead
R7522 T26373 T26371 punct ),arrowhead
R7523 T26374 T26366 punct ", ",in
R7524 T26375 T26366 cc and,in
R7525 T26376 T26366 conj in,in
R7526 T26377 T26378 det the,ureter
R7527 T26378 T26376 pobj ureter,in
R7528 T26379 T26378 cc and,ureter
R7529 T26380 T26381 amod ureteric,compartment
R7530 T26381 T26378 conj compartment,ureter
R7531 T26382 T26381 prep of,compartment
R7532 T26383 T26384 det the,kidneys
R7533 T26384 T26382 pobj kidneys,of
R7534 T26385 T26384 amod developing,kidneys
R7535 T26386 T26387 punct (,circles
R7536 T26387 T26378 parataxis circles,ureter
R7537 T26388 T26387 amod dashed,circles
R7538 T26389 T26387 punct ),circles
R7539 T26390 T26349 punct ", ",lost
R7540 T26391 T26349 prep except,lost
R7541 T26392 T26391 prep for,except
R7542 T26393 T26394 punct (,K
R7543 T26394 T26395 parataxis K,cells
R7544 T26395 T26392 pobj cells,for
R7545 T26396 T26394 punct ),K
R7546 T26397 T26395 det a,cells
R7547 T26398 T26395 amod few,cells
R7548 T26399 T26400 advmod faintly,staining
R7549 T26400 T26395 amod staining,cells
R7550 T26401 T26349 punct .,lost
R7551 T26403 T26404 punct (,M
R7552 T26404 T26405 meta M,kidneys
R7553 T26406 T26404 punct ", ",M
R7554 T26407 T26404 dep N,M
R7555 T26408 T26404 punct ),M
R7556 T26409 T26405 nmod Pygo1,kidneys
R7557 T26410 T26409 punct +,Pygo1
R7558 T26411 T26409 punct /,Pygo1
R7559 T26412 T26409 punct -,Pygo1
R7560 T26413 T26409 punct /,Pygo1
R7561 T26414 T26409 appos Pygo2,Pygo1
R7562 T26415 T26414 punct +,Pygo2
R7563 T26416 T26414 punct /,Pygo2
R7564 T26417 T26414 punct -,Pygo2
R7565 T26418 T26419 punct (,left
R7566 T26419 T26409 parataxis left,Pygo1
R7567 T26420 T26419 punct ),left
R7568 T26421 T26409 cc and,Pygo1
R7569 T26422 T26409 conj Pygo1,Pygo1
R7570 T26423 T26422 punct -,Pygo1
R7571 T26424 T26422 punct /,Pygo1
R7572 T26425 T26422 punct -,Pygo1
R7573 T26426 T26422 punct /,Pygo1
R7574 T26427 T26422 appos Pygo2,Pygo1
R7575 T26428 T26427 punct -,Pygo2
R7576 T26429 T26427 punct /,Pygo2
R7577 T26430 T26427 punct -,Pygo2
R7578 T26431 T26432 punct (,right
R7579 T26432 T26422 parataxis right,Pygo1
R7580 T26433 T26432 punct ),right
R7581 T26434 T26405 compound E18.5,kidneys
R7582 T26435 T26405 punct .,kidneys
R7583 T26437 T26438 det The,kidneys
R7584 T26438 T26439 nsubjpass kidneys,bisected
R7585 T26440 T26438 prep in,kidneys
R7586 T26441 T26440 punct (,in
R7587 T26442 T26440 pobj N,in
R7588 T26443 T26439 punct ),bisected
R7589 T26444 T26439 auxpass were,bisected
R7590 T26445 T26439 punct .,bisected
R7591 T26447 T26448 compound BAT,gal
R7592 T26448 T26450 compound gal,reporter
R7593 T26449 T26448 punct -,gal
R7594 T26450 T26451 compound reporter,expression
R7595 T26451 T26452 nsubjpass expression,seen
R7596 T26453 T26452 auxpass was,seen
R7597 T26454 T26452 prep in,seen
R7598 T26455 T26456 det the,components
R7599 T26456 T26454 pobj components,in
R7600 T26457 T26458 amod ureteric,tree
R7601 T26458 T26456 compound tree,components
R7602 T26459 T26456 prep of,components
R7603 T26460 T26461 det the,cortex
R7604 T26461 T26459 pobj cortex,of
R7605 T26462 T26461 cc and,cortex
R7606 T26463 T26461 conj medulla,cortex
R7607 T26464 T26461 prep of,cortex
R7608 T26465 T26466 det the,heterozygotes
R7609 T26466 T26464 pobj heterozygotes,of
R7610 T26467 T26466 amod double,heterozygotes
R7611 T26468 T26452 cc but,seen
R7612 T26469 T26470 auxpass was,lost
R7613 T26470 T26452 conj lost,seen
R7614 T26471 T26472 advmod almost,completely
R7615 T26472 T26470 advmod completely,lost
R7616 T26473 T26470 prep in,lost
R7617 T26474 T26475 det the,mutants
R7618 T26475 T26473 pobj mutants,in
R7619 T26476 T26477 amod double,homozygous
R7620 T26477 T26475 amod homozygous,mutants
R7621 T26478 T26477 punct -,homozygous
R7622 T26479 T26452 punct .,seen
R7623 T26481 T26482 punct (,O
R7624 T26482 T26483 meta O,kidneys
R7625 T26484 T26482 punct ),O
R7626 T26485 T26483 nmod Pygo1,kidneys
R7627 T26486 T26485 punct +,Pygo1
R7628 T26487 T26485 punct /,Pygo1
R7629 T26488 T26485 punct -,Pygo1
R7630 T26489 T26485 punct /,Pygo1
R7631 T26490 T26485 appos Pygo2,Pygo1
R7632 T26491 T26490 punct +,Pygo2
R7633 T26492 T26490 punct /,Pygo2
R7634 T26493 T26490 punct +,Pygo2
R7635 T26494 T26495 punct (,left
R7636 T26495 T26485 parataxis left,Pygo1
R7637 T26496 T26495 punct ),left
R7638 T26497 T26485 punct ", ",Pygo1
R7639 T26498 T26485 conj Pygo1,Pygo1
R7640 T26499 T26498 punct -,Pygo1
R7641 T26500 T26498 punct /,Pygo1
R7642 T26501 T26498 punct -,Pygo1
R7643 T26502 T26498 punct /,Pygo1
R7644 T26503 T26498 appos Pygo2,Pygo1
R7645 T26504 T26503 punct +,Pygo2
R7646 T26505 T26503 punct /,Pygo2
R7647 T26506 T26503 punct -,Pygo2
R7648 T26507 T26508 punct (,middle
R7649 T26508 T26498 parataxis middle,Pygo1
R7650 T26509 T26508 punct ),middle
R7651 T26510 T26498 punct ", ",Pygo1
R7652 T26511 T26498 cc and,Pygo1
R7653 T26512 T26498 conj Pygo1,Pygo1
R7654 T26513 T26512 punct -,Pygo1
R7655 T26514 T26512 punct /,Pygo1
R7656 T26515 T26512 punct -,Pygo1
R7657 T26516 T26512 punct /,Pygo1
R7658 T26517 T26512 appos Pygo2,Pygo1
R7659 T26518 T26517 punct -,Pygo2
R7660 T26519 T26517 punct /,Pygo2
R7661 T26520 T26517 punct -,Pygo2
R7662 T26521 T26522 punct (,right
R7663 T26522 T26512 parataxis right,Pygo1
R7664 T26523 T26522 punct ),right
R7665 T26524 T26483 compound E18.5,kidneys
R7666 T26525 T26483 punct .,kidneys
R7667 T26527 T26528 compound Reporter,activity
R7668 T26528 T26529 nsubj activity,was
R7669 T26530 T26529 acomp present,was
R7670 T26531 T26529 prep in,was
R7671 T26532 T26533 det the,compartments
R7672 T26533 T26531 pobj compartments,in
R7673 T26534 T26533 amod ureteric,compartments
R7674 T26535 T26533 prep of,compartments
R7675 T26536 T26537 det the,kidneys
R7676 T26537 T26535 pobj kidneys,of
R7677 T26538 T26537 nmod Pygo1,kidneys
R7678 T26539 T26538 punct +,Pygo1
R7679 T26540 T26538 punct /,Pygo1
R7680 T26541 T26538 punct -,Pygo1
R7681 T26542 T26538 punct /,Pygo1
R7682 T26543 T26538 appos Pygo2,Pygo1
R7683 T26544 T26543 punct +,Pygo2
R7684 T26545 T26543 punct /,Pygo2
R7685 T26546 T26543 punct +,Pygo2
R7686 T26547 T26548 punct (,left
R7687 T26548 T26538 parataxis left,Pygo1
R7688 T26549 T26548 punct ),left
R7689 T26550 T26538 cc and,Pygo1
R7690 T26551 T26538 conj Pygo1,Pygo1
R7691 T26552 T26551 punct -,Pygo1
R7692 T26553 T26551 punct /,Pygo1
R7693 T26554 T26551 punct -,Pygo1
R7694 T26555 T26551 punct /,Pygo1
R7695 T26556 T26551 appos Pygo2,Pygo1
R7696 T26557 T26556 punct +,Pygo2
R7697 T26558 T26556 punct /,Pygo2
R7698 T26559 T26556 punct -,Pygo2
R7699 T26560 T26561 punct (,middle
R7700 T26561 T26551 parataxis middle,Pygo1
R7701 T26562 T26561 punct ),middle
R7702 T26563 T26529 punct ", ",was
R7703 T26564 T26529 cc but,was
R7704 T26565 T26529 conj lost,was
R7705 T26566 T26565 prep in,lost
R7706 T26567 T26568 det the,kidney
R7707 T26568 T26566 pobj kidney,in
R7708 T26569 T26568 nmod Pygo1,kidney
R7709 T26570 T26569 punct -,Pygo1
R7710 T26571 T26569 punct /,Pygo1
R7711 T26572 T26569 punct -,Pygo1
R7712 T26573 T26569 punct /,Pygo1
R7713 T26574 T26569 appos Pygo2,Pygo1
R7714 T26575 T26574 punct -,Pygo2
R7715 T26576 T26574 punct /,Pygo2
R7716 T26577 T26574 punct -,Pygo2
R7717 T26578 T26579 punct (,right
R7718 T26579 T26569 parataxis right,Pygo1
R7719 T26580 T26579 punct ),right
R7720 T26581 T26529 punct .,was
R7721 T26583 T26584 amod Original,magnification
R7722 T26584 T26585 dep magnification,32
R7723 T26586 T26585 punct : ,32
R7724 T26587 T26588 punct (,A
R7725 T26588 T26585 parataxis A,32
R7726 T26589 T26590 punct -,C
R7727 T26590 T26588 prep C,A
R7728 T26591 T26588 punct ),A
R7729 T26592 T26585 punct ×,32
R7730 T26593 T26585 punct ", ",32
R7731 T26594 T26595 punct (,D
R7732 T26595 T26596 parataxis D,63
R7733 T26596 T26585 conj 63,32
R7734 T26597 T26598 punct -,F
R7735 T26598 T26595 prep F,D
R7736 T26599 T26595 punct ),D
R7737 T26600 T26596 punct ×,63
R7738 T26601 T26596 punct ", ",63
R7739 T26602 T26603 punct (,G
R7740 T26603 T26604 parataxis G,40
R7741 T26604 T26596 conj 40,63
R7742 T26605 T26606 punct -,I
R7743 T26606 T26603 prep I,G
R7744 T26607 T26603 punct ),G
R7745 T26608 T26604 punct ×,40
R7746 T26609 T26604 punct ", ",40
R7747 T26610 T26611 punct (,J
R7748 T26611 T26612 parataxis J,50
R7749 T26612 T26604 conj 50,40
R7750 T26613 T26614 punct -,L
R7751 T26614 T26611 prep L,J
R7752 T26615 T26611 punct ),J
R7753 T26616 T26612 punct ×,50
R7754 T26617 T26612 punct ", ",50
R7755 T26618 T26619 punct (,N
R7756 T26619 T26622 parataxis N,10
R7757 T26620 T26619 nmod M,N
R7758 T26621 T26619 punct ", ",N
R7759 T26622 T26612 conj 10,50
R7760 T26623 T26619 punct ),N
R7761 T26624 T26622 punct ×,10
R7762 T26625 T26622 punct ", ",10
R7763 T26626 T26622 cc and,10
R7764 T26627 T26628 punct (,O
R7765 T26628 T26629 parataxis O,12.5
R7766 T26629 T26622 conj 12.5,10
R7767 T26630 T26628 punct ),O
R7768 T26631 T26629 punct ×,12.5
R7769 T26632 T26585 punct .,32
R7770 T26917 T26918 amod Quantitative,analysis
R7771 T26919 T26918 prep of,analysis
R7772 T26920 T26921 compound BAT,gal
R7773 T26921 T26923 compound gal,reporter
R7774 T26922 T26921 punct -,gal
R7775 T26923 T26924 compound reporter,expression
R7776 T26924 T26919 pobj expression,of
R7777 T26925 T26924 prep in,expression
R7778 T26926 T26927 compound Pygo1,Pygo2
R7779 T26927 T26929 compound Pygo2,extracts
R7780 T26928 T26927 punct /,Pygo2
R7781 T26929 T26925 pobj extracts,in
R7782 T26930 T26929 compound E18.5,extracts
R7783 T26931 T26929 compound kidney,extracts
R7784 T26932 T26918 punct .,analysis
R7785 T26934 T26935 npadvmod Transgene,specific
R7786 T26935 T26937 amod specific,galactosidase
R7787 T26936 T26935 punct -,specific
R7788 T26937 T26940 nsubjpass galactosidase,quantified
R7789 T26938 T26937 compound beta,galactosidase
R7790 T26939 T26937 punct -,galactosidase
R7791 T26941 T26940 auxpass was,quantified
R7792 T26942 T26940 prep by,quantified
R7793 T26943 T26944 compound ELISA,analysis
R7794 T26944 T26942 pobj analysis,by
R7795 T26945 T26940 punct .,quantified
R7796 T26947 T26948 nmod Pygo1,kidneys
R7797 T26948 T26977 nsubj kidneys,showed
R7798 T26949 T26947 punct +,Pygo1
R7799 T26950 T26947 punct /,Pygo1
R7800 T26951 T26947 punct -,Pygo1
R7801 T26952 T26947 punct /,Pygo1
R7802 T26953 T26947 appos Pygo2,Pygo1
R7803 T26954 T26953 punct +,Pygo2
R7804 T26955 T26953 punct /,Pygo2
R7805 T26956 T26953 punct +,Pygo2
R7806 T26957 T26947 punct ", ",Pygo1
R7807 T26958 T26947 conj Pygo1,Pygo1
R7808 T26959 T26958 punct +,Pygo1
R7809 T26960 T26958 punct /,Pygo1
R7810 T26961 T26958 punct -,Pygo1
R7811 T26962 T26958 punct /,Pygo1
R7812 T26963 T26958 appos Pygo2,Pygo1
R7813 T26964 T26963 punct +,Pygo2
R7814 T26965 T26963 punct /,Pygo2
R7815 T26966 T26963 punct -,Pygo2
R7816 T26967 T26958 cc and,Pygo1
R7817 T26968 T26958 conj Pygo1,Pygo1
R7818 T26969 T26968 punct +,Pygo1
R7819 T26970 T26968 punct /,Pygo1
R7820 T26971 T26968 punct -,Pygo1
R7821 T26972 T26968 punct /,Pygo1
R7822 T26973 T26968 appos Pygo2,Pygo1
R7823 T26974 T26973 punct +,Pygo2
R7824 T26975 T26973 punct /,Pygo2
R7825 T26976 T26973 punct +,Pygo2
R7826 T26978 T26948 appos all,kidneys
R7827 T26979 T26980 amod similar,levels
R7828 T26980 T26977 dobj levels,showed
R7829 T26981 T26980 prep of,levels
R7830 T26982 T26983 compound BAT,gal
R7831 T26983 T26985 compound gal,expression
R7832 T26984 T26983 punct -,gal
R7833 T26985 T26981 pobj expression,of
R7834 T26986 T26977 punct .,showed
R7835 T26988 T26989 prep In,reduced
R7836 T26990 T26991 det the,mutants
R7837 T26991 T26988 pobj mutants,In
R7838 T26992 T26993 nmod Pygo2,hetereozygote
R7839 T26993 T26991 nmod hetereozygote,mutants
R7840 T26994 T26991 punct ", ",mutants
R7841 T26995 T26996 npadvmod Pygo1,homozygous
R7842 T26996 T26991 amod homozygous,mutants
R7843 T26997 T26989 punct ", ",reduced
R7844 T26998 T26989 advmod however,reduced
R7845 T26999 T26989 punct ", ",reduced
R7846 T27000 T27001 compound reporter,expression
R7847 T27001 T26989 nsubjpass expression,reduced
R7848 T27002 T26989 auxpass was,reduced
R7849 T27003 T26989 prep by,reduced
R7850 T27004 T27005 quantmod about,50
R7851 T27005 T27006 nummod 50,%
R7852 T27006 T27003 pobj %,by
R7853 T27007 T26989 punct .,reduced
R7854 T27009 T27010 prep In,was
R7855 T27011 T27012 npadvmod Pygo2,homozygous
R7856 T27012 T27013 amod homozygous,mutants
R7857 T27013 T27009 pobj mutants,In
R7858 T27014 T27015 compound BAT,gal
R7859 T27015 T27017 compound gal,expression
R7860 T27016 T27015 punct -,gal
R7861 T27017 T27010 nsubj expression,was
R7862 T27018 T27019 advmod uniformly,low
R7863 T27019 T27010 acomp low,was
R7864 T27020 T27010 punct ", ",was
R7865 T27021 T27010 prep with,was
R7866 T27022 T27021 cc or,with
R7867 T27023 T27021 conj without,with
R7868 T27024 T27025 amod wild,type
R7869 T27025 T27027 compound type,alleles
R7870 T27026 T27025 punct -,type
R7871 T27027 T27023 pobj alleles,without
R7872 T27028 T27027 compound Pygo1,alleles
R7873 T27029 T27010 punct .,was
R7874 T27031 T27032 det Each,group
R7875 T27032 T27034 nsubj group,included
R7876 T27033 T27032 amod experimental,group
R7877 T27035 T27036 det a,size
R7878 T27036 T27034 dobj size,included
R7879 T27037 T27036 compound sample,size
R7880 T27038 T27036 prep of,size
R7881 T27039 T27040 advmod at,four
R7882 T27040 T27038 pobj four,of
R7883 T27041 T27040 advmod least,four
R7884 T27042 T27034 punct .,included
R7885 T27272 T27273 compound Gene,expression
R7886 T27273 T27274 compound expression,changes
R7887 T27275 T27274 prep of,changes
R7888 T27276 T27277 amod common,targets
R7889 T27277 T27275 pobj targets,of
R7890 T27278 T27277 compound Wnt,targets
R7891 T27279 T27277 compound signaling,targets
R7892 T27280 T27274 prep in,changes
R7893 T27281 T27282 det the,kidney
R7894 T27282 T27280 pobj kidney,in
R7895 T27283 T27282 nmod E18.5,kidney
R7896 T27284 T27285 compound Pygo1,Pygo2
R7897 T27285 T27287 npadvmod Pygo2,null
R7898 T27286 T27285 punct /,Pygo2
R7899 T27287 T27282 amod null,kidney
R7900 T27288 T27274 punct .,changes
R7901 T27290 T27291 compound Microarray,analysis
R7902 T27291 T27292 nsubjpass analysis,performed
R7903 T27293 T27292 auxpass was,performed
R7904 T27294 T27292 prep in,performed
R7905 T27295 T27294 pobj triplicate,in
R7906 T27296 T27292 prep on,performed
R7907 T27297 T27298 amod wild,type
R7908 T27298 T27300 nmod type,kidneys
R7909 T27299 T27298 punct -,type
R7910 T27300 T27296 pobj kidneys,on
R7911 T27301 T27298 cc and,type
R7912 T27302 T27303 npadvmod Pygo1,null
R7913 T27303 T27298 conj null,type
R7914 T27304 T27302 punct /,Pygo1
R7915 T27305 T27302 nummod 2,Pygo1
R7916 T27306 T27303 npadvmod compound,null
R7917 T27307 T27300 compound E18.5,kidneys
R7918 T27308 T27292 punct .,performed
R7919 T27310 T27311 amod Possible,targets
R7920 T27311 T27313 nsubjpass targets,selected
R7921 T27312 T27311 compound Wnt,targets
R7922 T27314 T27313 auxpass were,selected
R7923 T27315 T27313 prep from,selected
R7924 T27316 T27315 pobj those,from
R7925 T27317 T27316 acl compiled,those
R7926 T27318 T27317 prep at,compiled
R7927 T27319 T27318 punct [,at
R7928 T27320 T27318 pobj 39,at
R7929 T27321 T27313 punct ],selected
R7930 T27322 T27313 punct .,selected
R7931 T27324 T27325 det An,list
R7932 T27325 T27328 nsubjpass list,created
R7933 T27326 T27325 amod initial,list
R7934 T27327 T27325 compound gene,list
R7935 T27329 T27325 prep of,list
R7936 T27330 T27331 nummod 82,targets
R7937 T27331 T27329 pobj targets,of
R7938 T27332 T27331 compound Wnt,targets
R7939 T27333 T27328 auxpass was,created
R7940 T27334 T27328 cc and,created
R7941 T27335 T27336 advmod then,reduced
R7942 T27336 T27328 conj reduced,created
R7943 T27337 T27336 prep to,reduced
R7944 T27338 T27339 det a,total
R7945 T27339 T27337 pobj total,to
R7946 T27340 T27339 prep of,total
R7947 T27341 T27342 nummod 40,genes
R7948 T27342 T27340 pobj genes,of
R7949 T27343 T27336 advcl using,reduced
R7950 T27344 T27345 det an,restriction
R7951 T27345 T27343 dobj restriction,using
R7952 T27346 T27347 compound expression,level
R7953 T27347 T27345 compound level,restriction
R7954 T27348 T27345 acl requiring,restriction
R7955 T27349 T27350 det the,intensity
R7956 T27350 T27348 dobj intensity,requiring
R7957 T27351 T27350 amod raw,intensity
R7958 T27352 T27350 compound expression,intensity
R7959 T27353 T27354 aux to,be
R7960 T27354 T27348 xcomp be,requiring
R7961 T27355 T27356 punct >,100
R7962 T27356 T27354 attr 100,be
R7963 T27357 T27354 prep in,be
R7964 T27358 T27359 advmod at,3
R7965 T27359 T27361 nummod 3,samples
R7966 T27360 T27359 advmod least,3
R7967 T27361 T27357 pobj samples,in
R7968 T27362 T27328 punct .,created
R7969 T27364 T27365 nmod Pygo1,probes
R7970 T27365 T27368 nsubjpass probes,included
R7971 T27366 T27364 cc and,Pygo1
R7972 T27367 T27364 conj Pygo2,Pygo1
R7973 T27369 T27368 auxpass were,included
R7974 T27370 T27371 aux to,demonstrate
R7975 T27371 T27368 advcl demonstrate,included
R7976 T27372 T27373 amod significant,changes
R7977 T27373 T27371 dobj changes,demonstrate
R7978 T27374 T27373 prep in,changes
R7979 T27375 T27376 compound expression,levels
R7980 T27376 T27374 pobj levels,in
R7981 T27377 T27368 punct .,included
R7982 T27424 T27423 prep of,Phenotypes
R7983 T27425 T27426 dep Pygo2,type
R7984 T27426 T27429 nmod type,embryos
R7985 T27427 T27426 amod wild,type
R7986 T27428 T27426 punct -,type
R7987 T27429 T27424 pobj embryos,of
R7988 T27430 T27426 punct ", ",type
R7989 T27431 T27426 conj heterozyogous,type
R7990 T27432 T27431 punct ", ",heterozyogous
R7991 T27433 T27431 cc and,heterozyogous
R7992 T27434 T27431 conj null,heterozyogous
R7993 T27435 T27429 compound E18.5,embryos
R7994 T27436 T27429 prep on,embryos
R7995 T27437 T27438 det a,background
R7996 T27438 T27436 pobj background,on
R7997 T27439 T27440 npadvmod Pygo1,null
R7998 T27440 T27438 amod null,background
R7999 T27441 T27423 punct .,Phenotypes
R8000 T27487 T27488 amod Confocal,analysis
R8001 T27489 T27488 prep of,analysis
R8002 T27490 T27491 dep Pygo2,type
R8003 T27491 T27494 nmod type,kidneys
R8004 T27492 T27491 amod wild,type
R8005 T27493 T27491 punct -,type
R8006 T27494 T27489 pobj kidneys,of
R8007 T27495 T27491 punct ", ",type
R8008 T27496 T27491 conj heterozygous,type
R8009 T27497 T27496 punct ", ",heterozygous
R8010 T27498 T27496 cc and,heterozygous
R8011 T27499 T27496 conj null,heterozygous
R8012 T27500 T27494 compound E18.5,kidneys
R8013 T27501 T27488 prep on,analysis
R8014 T27502 T27503 det the,background
R8015 T27503 T27501 pobj background,on
R8016 T27504 T27505 npadvmod Pygo1,null
R8017 T27505 T27503 amod null,background
R8018 T27506 T27488 punct .,analysis
R8019 T27573 T27574 advmod differentially,expressed
R8020 T27574 T27572 acl expressed,Genes
R8021 T27575 T27576 punct (,change
R8022 T27576 T27574 parataxis change,expressed
R8023 T27577 T27578 nsubj p,0.05
R8024 T27578 T27576 ccomp 0.05,change
R8025 T27579 T27578 punct <,0.05
R8026 T27580 T27576 punct ", ",change
R8027 T27581 T27576 amod two-fold,change
R8028 T27582 T27583 cc or,greater
R8029 T27583 T27576 nummod greater,change
R8030 T27584 T27576 punct ),change
R8031 T27585 T27574 prep in,expressed
R8032 T27586 T27587 det the,kidney
R8033 T27587 T27585 pobj kidney,in
R8034 T27588 T27589 compound Pygo1,Pygo2
R8035 T27589 T27591 npadvmod Pygo2,null
R8036 T27590 T27589 punct /,Pygo2
R8037 T27591 T27587 amod null,kidney
R8038 T27592 T27587 compound E18.5,kidney
R8039 T27593 T27587 acl normalized,kidney
R8040 T27594 T27593 prep to,normalized
R8041 T27595 T27596 amod wild,type
R8042 T27596 T27598 compound type,samples
R8043 T27597 T27596 punct -,type
R8044 T27598 T27594 pobj samples,to
R8045 T27599 T27572 punct .,Genes
R8046 T27656 T27655 prep of,Validation
R8047 T27657 T27658 compound gene,expression
R8048 T27658 T27659 compound expression,changes
R8049 T27659 T27656 pobj changes,of
R8050 T27660 T27659 prep in,changes
R8051 T27661 T27662 det the,kidneys
R8052 T27662 T27660 pobj kidneys,in
R8053 T27663 T27662 nmod E18.5,kidneys
R8054 T27664 T27665 compound Pygo1,Pygo2
R8055 T27665 T27667 npadvmod Pygo2,null
R8056 T27666 T27665 punct /,Pygo2
R8057 T27667 T27662 amod null,kidneys
R8058 T27668 T27659 acl normalized,changes
R8059 T27669 T27668 prep to,normalized
R8060 T27670 T27671 nmod E18.5,kidneys
R8061 T27671 T27669 pobj kidneys,to
R8062 T27672 T27673 amod wild,type
R8063 T27673 T27671 compound type,kidneys
R8064 T27674 T27673 punct -,type
R8065 T27675 T27655 punct .,Validation
R1483 T5760 T5758 pobj cadherin,as
R1484 T5761 T5760 punct -,cadherin
R1485 T5762 T5763 punct (,blue
R1486 T5763 T5757 parataxis blue,known
R1487 T5764 T5763 punct ),blue
R1488 T5765 T5752 punct ", ",used
R1489 T5766 T5752 auxpass were,used
R1490 T5767 T5768 aux to,identify
R1491 T5768 T5752 advcl identify,used
R1492 T5769 T5770 amod epithelial,structures
R1493 T5770 T5768 dobj structures,identify
R1494 T5771 T5770 punct ", ",structures
R1495 T5772 T5770 prep including,structures
R1496 T5773 T5774 det the,bud
R1497 T5774 T5772 pobj bud,including
R1498 T5775 T5774 amod branching,bud
R1499 T5776 T5774 amod ureteric,bud
R1500 T5777 T5774 cc and,bud
R1501 T5778 T5779 amod nascent,nephrons
R1502 T5779 T5774 conj nephrons,bud
R1503 T5780 T5779 prep of,nephrons
R1504 T5781 T5782 det the,kidney
R1505 T5782 T5780 pobj kidney,of
R1506 T5783 T5782 amod developing,kidney
R1507 T5784 T5785 punct [,18
R1508 T5785 T5752 parataxis 18,used
R1509 T5786 T5785 punct ],18
R1510 T5787 T5752 punct .,used
R1511 T5789 T5790 nmod Dolichos,biflorus
R1512 T5790 T5791 nmod biflorus,lectin
R1513 T5791 T5795 nsubjpass lectin,used
R1533 T5820 T5818 cc d,C
R1534 T5833 T5832 pobj n,i
R1535 T5839 T5840 det an,increase
R1536 T5840 T5838 dobj increase,vealed
R1537 T5841 T5840 prep of,increase
R1538 T5842 T5843 advmod approximately,30
R1539 T5843 T5844 nummod 30,%
R1540 T5844 T5841 pobj %,of
R1541 T5845 T5840 prep in,increase
R1542 T5846 T5847 det the,thickness
R1543 T5847 T5845 pobj thickness,in
R1544 T5848 T5847 prep of,thickness
R1545 T5849 T5850 det the,mesenchyme
R1546 T5850 T5848 pobj mesenchyme,of
R1547 T5851 T5850 amod capping,mesenchyme
R1548 T5852 T5850 acl surrounding,mesenchyme
R1549 T5853 T5854 det the,buds
R1550 T5854 T5852 dobj buds,surrounding
R1551 T5855 T5854 nmod mutant,buds
R1552 T5856 T5854 amod ureteric,buds
R1553 T5857 T5858 punct (,Table
R1554 T5858 T5838 parataxis Table,vealed
R1555 T5859 T5858 dep Figure,Table
R1556 T5860 T5859 nummod 3,Figure
R1622 T5938 T5934 prep o,analysis
R1623 T5943 T5944 mark that,were
R1624 T5944 T5942 ccomp were,howed
R1625 T5945 T5946 det the,tips
R1626 T5946 T5944 nsubj tips,were
R1627 T5947 T5948 amod ureteric,bud
R1628 T5948 T5946 compound bud,tips
R1629 T5949 T5950 punct [,16
R1630 T5950 T5946 parataxis 16,tips
R1631 T5951 T5950 punct ],16
R1632 T5952 T5946 prep of,tips
R1633 T5953 T5954 compound Pygo1,Pygo2
R1634 T5954 T5956 npadvmod Pygo2,null
R1635 T5955 T5954 punct /,Pygo2
R1636 T5956 T5957 amod null,kidneys
R1637 T5957 T5952 pobj kidneys,of
R1638 T5958 T5944 acomp dilated,were
R1639 T5959 T5958 cc and,dilated
R1640 T5960 T5958 conj misshaped,dilated
R1641 T5961 T5944 prep compared,were
R1642 T5962 T5961 prep with,compared
R1643 T5963 T5962 pobj those,with
R1644 T5964 T5963 prep of,those
R1645 T5965 T5964 pobj littermates,of
R1646 T5966 T5965 prep with,littermates
R1647 T5967 T5968 advmod at,one
R1648 T5968 T5970 nummod one,allele
R1649 T5969 T5968 advmod least,one
R1650 T5970 T5966 pobj allele,with
R1651 T5971 T5972 amod wild,type
R1652 T5972 T5970 compound type,allele
R1653 T5973 T5972 punct -,type
R192 T1151 T1155 nsubj genes,showed
R227 T1189 T1185 amod derived,compartments
R363 T1341 T1337 nsubjpass genes,required
R904 T3189 T3188 punct ", ",mammals
R3238 T12277 T12271 advmod strongly,expressed
R3239 T12278 T12271 prep in,expressed
R3240 T12279 T12280 det the,tubules
R3241 T12280 T12278 pobj tubules,in
R3242 T12281 T12280 prep of,tubules
R3243 T12282 T12283 det the,kidney
R3244 T12283 T12281 pobj kidney,of
R3245 T12284 T12283 amod adult,kidney
R3246 T12285 T12286 punct [,24
R3247 T12286 T12271 parataxis 24,expressed
R3248 T12287 T12286 punct ],24
R3249 T12288 T12271 punct .,expressed
R3250 T12290 T12291 det These,results
R3251 T12291 T12292 nsubj results,suggest
R3252 T12293 T12294 mark that,play
R3253 T12294 T12292 ccomp play,suggest
R3254 T12295 T12296 det the,genes
R3255 T12296 T12294 nsubj genes,play
R3256 T12297 T12298 compound Pygo1,Pygo2
R3257 T12298 T12296 compound Pygo2,genes
R3258 T12299 T12298 punct /,Pygo2
R3259 T12300 T12294 aux might,play
R3260 T12301 T12302 det a,role
R3261 T12302 T12294 dobj role,play
R3262 T12303 T12294 prep in,play
R3263 T12304 T12305 compound nephron,maturation
R3264 T12305 T12303 pobj maturation,in
R3265 T12306 T12305 cc and,maturation
R3533 T12599 T12596 pobj genes,of
R3535 T12601 T12599 compound signaling,genes
R3536 T12602 T12599 compound target,genes
R3537 T12603 T12595 prep in,expression
R3538 T12604 T12605 det the,kidneys
R3539 T12605 T12603 pobj kidneys,in
R3540 T12606 T12607 compound Pygo1,Pygo2
R3541 T12607 T12609 compound Pygo2,mutant
R3542 T12608 T12607 punct /,Pygo2
R3543 T12609 T12605 compound mutant,kidneys
R3544 T12610 T12588 punct .,indicate
R3545 T12612 T12613 nsubj We,used
R3546 T12614 T12615 amod quantitative,PCR
R3547 T12615 T12613 dobj PCR,used
R3548 T12616 T12617 amod real,time
R3549 T12617 T12615 compound time,PCR
R3550 T12618 T12617 punct -,time
R3551 T12619 T12615 punct ", ",PCR
R3552 T12620 T12615 prep with,PCR
R3553 T12621 T12622 amod independent,samples
R3554 T12622 T12620 pobj samples,with
R3555 T12623 T12622 amod biological,samples
R3556 T12624 T12613 punct ", ",used
R3557 T12625 T12626 aux to,validate
R3558 T12626 T12613 advcl validate,used
R3559 T12627 T12628 det the,results
R3560 T12628 T12626 dobj results,validate
R3561 T12629 T12628 compound microarray,results
R3562 T12630 T12613 punct .,used
R3563 T12632 T12633 nummod Nine,genes
R3564 T12633 T12634 nsubjpass genes,tested
R3565 T12635 T12634 auxpass were,tested
R3566 T12636 T12634 punct ", ",tested
R3567 T12637 T12634 cc and,tested
R3568 T12638 T12639 prep for,observe
R3569 T12639 T12634 conj observe,tested
R3570 T12640 T12638 pobj seven,for
R3571 T12641 T12639 nsubj we,observe
R3572 T12642 T12639 aux did,observe
R1893 T9410 T9411 mark while,showed
R1895 T9411 T9402 advcl showed,showing
R1896 T9412 T9413 det the,telencephalon
R1897 T9413 T9411 nsubj telencephalon,showed
R1898 T9414 T9413 compound mutant,telencephalon
R1899 T9415 T9411 advmod still,showed
R1900 T9416 T9417 amod robust,signaling
R1901 T9417 T9411 dobj signaling,showed
R1902 T9418 T9417 compound Wnt,signaling
R1903 T9419 T9385 punct .,was
R1904 T9421 T9422 det These,results
R1905 T9422 T9423 nsubj results,suggest
R1907 T9424 T9425 mark that,are
R1908 T9425 T9423 ccomp are,suggest
R1909 T9426 T9427 det the,genes
R1910 T9427 T9425 nsubj genes,are
R1911 T9428 T9427 amod mammalian,genes
R1913 T9429 T9427 compound Pygo,genes
R1914 T9430 T9431 amod significant,modulators
R1915 T9431 T9425 attr modulators,are
R1916 T9432 T9431 prep of,modulators
R1918 T9433 T9434 amod canonical,signaling
R1919 T9434 T9432 pobj signaling,of
R1921 T9435 T9434 compound Wnt,signaling
R1948 T9465 T9466 compound BAT,gal
R1949 T9466 T9464 compound gal,re
R1950 T9467 T9466 punct -,gal
R1959 T9478 T9479 compound pre,ssion
R1960 T9479 T9477 dobj ssion,x
R1962 T9480 T9477 prep in,x
R1963 T9481 T9482 amod more,detail
R1964 T9482 T9480 pobj detail,in
R1966 T9483 T9477 prep in,x
R1967 T9484 T9485 det the,system
R1970 T9485 T9483 pobj system,in
R1972 T9486 T9485 amod developing,system
R1973 T9487 T9485 amod urogenital,system
R1975 T9488 T9485 prep of,system
R1976 T9489 T9490 compound Pygo,mutants
R1977 T9490 T9488 pobj mutants,of
R1979 T9491 T9477 punct .,x
R1981 T9493 T9494 det The,results
R2029 T9591 T9587 punct ),6A
R2033 T9592 T9550 punct .,form
R2037 T9599 T9598 conj 3.5,E1
R2081 T9578 T9576 dobj expression,showed
R2084 T9581 T9577 conj absent,reduced
R2085 T9582 T9583 compound BAT,gal
R2086 T9583 T9585 compound gal,reporter
R2087 T9584 T9583 punct -,gal
R2088 T9585 T9578 compound reporter,expression
R2089 T9586 T9587 punct (,6A
R2090 T9587 T9576 parataxis 6A,showed
R2091 T9588 T9587 compound Figure,6A
R2092 T9589 T9590 punct –,C
R2094 T9590 T9587 prep C,6A
R2050 T9614 T9615 compound p,pe
R2077 T9627 T9626 punct ,y
R2093 T9632 T9631 amod jor,role
R2095 T9635 T9636 det the,gene
R2096 T9636 T9638 nsubj gene,role
R2097 T9637 T9636 compound Pygo1,gene
R2098 T9639 T9638 det a,role
R2099 T9643 T9644 amod canonical,signaling
R2100 T9640 T9638 amod minor,role
R2101 T9644 T9642 pobj signaling,in
R2102 T9645 T9644 compound Wnt,signaling
R2103 T9641 T9638 punct ", ",role
R2104 T9646 T9644 prep in,signaling
R2105 T9647 T9648 det the,tree
R2106 T9648 T9646 pobj tree,in
R2107 T9649 T9648 amod ureteric,tree
R2108 T9651 T9652 mark as,measured
R2109 T9642 T9638 conj in,role
R2110 T9653 T9652 agent by,measured
R2111 T9654 T9655 compound BAT,gal
R2112 T9655 T9657 compound gal,expression
R2113 T9656 T9655 punct -,gal
R2115 T9657 T9653 pobj expression,by
R2117 T9660 T9661 det A,kidney
R2118 T9661 T9664 nsubj kidney,showed
R2119 T9662 T9661 amod negative,kidney
R2120 T9663 T9661 compound control,kidney
R2122 T9665 T9661 punct ", ",kidney
R2123 T9666 T9661 prep without,kidney
R2125 T9667 T9668 det the,transgene
R2126 T9668 T9666 pobj transgene,without
R2127 T9669 T9670 compound BAT,gal
R2128 T9670 T9668 compound gal,transgene
R2130 T9671 T9670 punct -,gal
R2131 T9672 T9664 punct ", ",showed
R2132 T9673 T9674 amod minimal,background
R2134 T9674 T9675 compound background,staining
R2137 T9676 T9677 compound X,gal
R2140 T9678 T9677 punct -,gal
R2755 T10355 T10353 pobj tree,of
R2757 T10356 T10355 amod ureteric,tree
R2758 T10357 T10355 prep of,tree
R2760 T10358 T10359 det the,kidney
R2761 T10359 T10357 pobj kidney,of
R2762 T10360 T10330 punct .,suggest
R2772 T10362 T10363 advmod Interestingly,showed
R2774 T10364 T10363 punct ", ",showed
R2776 T10365 T10363 advmod however,showed
R2777 T10366 T10363 punct ", ",showed
R2779 T10367 T10368 advmod even,in
R2780 T10368 T10363 prep in,showed
R2781 T10369 T10370 amod wild,type
R2783 T10370 T10372 compound type,mice
R2784 T10371 T10370 punct -,type
R2785 T10372 T10368 pobj mice,in
R2786 T10373 T10374 det the,reporter
R2787 T10374 T10363 nsubj reporter,showed
R2789 T10375 T10376 compound BAT,gal
R2790 T10376 T10374 compound gal,reporter
R2791 T10377 T10376 punct -,gal
R2792 T10378 T10379 det no,expression
R2794 T10379 T10363 dobj expression,showed
R2795 T10380 T10379 prep in,expression
R2797 T10381 T10382 det the,mesenchyme
R2798 T10382 T10380 pobj mesenchyme,in
R2799 T10383 T10382 amod developing,mesenchyme
R2801 T10384 T10382 amod metanephric,mesenchyme
R2802 T10385 T10382 punct ", ",mesenchyme
R2803 T10386 T10382 cc or,mesenchyme
R2805 T10387 T10388 amod metanephric,mesenchyme
R2806 T10388 T10389 npadvmod mesenchyme,derived
R2807 T10389 T10391 amod derived,structures
R2809 T10390 T10389 punct -,derived
R2810 T10391 T10382 conj structures,mesenchyme
R2812 T10392 T10391 punct ", ",structures
R2813 T10393 T10394 amod such,as
R2814 T10394 T10391 prep as,structures
R2815 T10395 T10396 amod renal,vesicles
R2817 T10396 T10394 pobj vesicles,as
R2818 T10397 T10396 punct ", ",vesicles
R2820 T10398 T10399 npadvmod S,shaped
R2821 T10399 T10401 amod shaped,bodies
R2822 T10400 T10399 punct -,shaped
R2823 T10401 T10396 conj bodies,vesicles
R2824 T10402 T10401 punct ", ",bodies
R4611 T16417 T16418 amod canonical,signaling
R4613 T16418 T16416 pobj signaling,to
R4614 T16419 T16418 compound Wnt,signaling
R4616 T16420 T16409 punct ", ",dedicated
R4617 T16421 T16422 mark as,shown
R4618 T16422 T16409 advcl shown,dedicated
R4619 T16423 T16422 aux has,shown
R4621 T16424 T16422 auxpass been,shown
R4622 T16425 T16422 advmod previously,shown

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T27571 25100-25109 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27570 25079-25085 UBERON:0002113 denotes kidney
T27569 25068-25072 SO_EXT:sequence_nullness denotes null
T27568 25062-25067 PR_EXT:000013524 denotes Pygo2
T27567 25056-25061 PR_EXT:000013523 denotes Pygo1
T27566 25000-25009 GO:0010467 denotes expressed
T27565 24979-24984 SO_EXT:0000704 denotes Genes
T26916 22203-22210 SO_EXT:0001023 denotes alleles
T26915 22197-22202 PR_EXT:000013523 denotes Pygo1
T26914 22187-22196 SO_EXT:wild_type_entity_or_quality denotes wild-type
T26913 22141-22151 GO:0010467 denotes expression
T26912 22137-22140 GO_EXT:0015925 denotes gal
T26911 22125-22132 SO_EXT:sequence_altered_entity denotes mutants
T26910 22108-22113 PR_EXT:000013524 denotes Pygo2
T26909 22068-22078 GO:0010467 denotes expression
T26908 22041-22048 SO_EXT:sequence_altered_entity denotes mutants
T26907 22024-22029 PR_EXT:000013523 denotes Pygo1
T26906 22003-22008 PR_EXT:000013524 denotes Pygo2
T27271 29060-29070 GO:0010467 denotes expression
T27270 29001-29007 CHEBI_SO_EXT:molecular_probe denotes probes
T27269 28995-29000 PR_EXT:000013524 denotes Pygo2
T27268 28985-28990 PR_EXT:000013523 denotes Pygo1
T27267 28930-28940 GO:0010467 denotes expression
T27266 28868-28873 SO_EXT:0000704 denotes genes
T27265 28794-28798 SO_EXT:0000704 denotes gene
T27264 28710-28717 UBERON:0002113 denotes kidneys
T27263 28699-28703 SO_EXT:sequence_nullness denotes null
T27262 28682-28687 PR_EXT:000013523 denotes Pygo1
T27261 28668-28677 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27260 28609-28615 UBERON:0002113 denotes kidney
T27259 28604-28608 SO_EXT:sequence_nullness denotes null
T27258 28598-28603 PR_EXT:000013524 denotes Pygo2
T27257 28592-28597 PR_EXT:000013523 denotes Pygo1
T25794 16503-16506 GO_EXT:0015925 denotes gal
T25793 16487-16493 UBERON:0000922 denotes embryo
T25792 16479-16480 SO_EXT:sequence_nullness_or_absence denotes -
T25791 16477-16478 SO_EXT:normal_or_wild_type_or_present denotes +
T25790 16472-16477 PR_EXT:000013524 denotes Pygo2
T25789 16470-16471 SO_EXT:sequence_nullness_or_absence denotes -
T25788 16468-16469 SO_EXT:sequence_nullness_or_absence denotes -
T25787 16463-16468 PR_EXT:000013523 denotes Pygo1
T25786 16443-16449 UBERON:0000922 denotes embryo
T25785 16438-16442 SO_EXT:sequence_nullness denotes null
T25784 16432-16437 PR_EXT:000013524 denotes Pygo2
T25783 16398-16410 UBERON:0000084 denotes ureteric bud
T25782 16334-16346 UBERON:0009201 denotes nephric duct
T25781 16281-16282 SO_EXT:sequence_nullness_or_absence denotes -
T25780 16279-16280 SO_EXT:sequence_nullness_or_absence denotes -
T25779 16274-16279 PR_EXT:000013524 denotes Pygo2
T25778 16272-16273 SO_EXT:sequence_nullness_or_absence denotes -
T25777 16270-16271 SO_EXT:normal_or_wild_type_or_present denotes +
T25776 16265-16270 PR_EXT:000013523 denotes Pygo1
T25775 16252-16253 SO_EXT:normal_or_wild_type_or_present denotes +
T25774 16250-16251 SO_EXT:normal_or_wild_type_or_present denotes +
T25773 16245-16250 PR_EXT:000013524 denotes Pygo2
T25772 16243-16244 SO_EXT:sequence_nullness_or_absence denotes -
T25771 16241-16242 SO_EXT:sequence_nullness_or_absence denotes -
T25770 16236-16241 PR_EXT:000013523 denotes Pygo1
T25769 16223-16230 UBERON:0002113 denotes kidneys
T25768 16188-16198 UBERON:0004122 denotes urogenital
T25767 16148-16158 SO_EXT:transgenic_entity denotes transgenic
T25766 16144-16147 GO_EXT:0015925 denotes gal
T25765 16122-16127 CHEBI:75055 denotes X-Gal
T25764 16114-16120 UBERON:0002113 denotes kidney
T25763 16064-16076 UBERON:0000084 denotes ureteric bud
T25762 16050-16060 GO:0010467 denotes expression
T25761 16037-16040 GO_EXT:0015925 denotes gal
T25760 16011-16016 PR_EXT:000013524 denotes Pygo2
T25933 18409-18415 UBERON:0002113 denotes kidney
T25932 18399-18400 SO_EXT:sequence_nullness_or_absence denotes -
T25931 18397-18398 SO_EXT:sequence_nullness_or_absence denotes -
T25930 18392-18397 PR_EXT:000013524 denotes Pygo2
T25929 18390-18391 SO_EXT:sequence_nullness_or_absence denotes -
T25928 18388-18389 SO_EXT:sequence_nullness_or_absence denotes -
T25927 18383-18388 PR_EXT:000013523 denotes Pygo1
T25926 18358-18365 UBERON:0002113 denotes kidneys
T25925 18347-18348 SO_EXT:sequence_nullness_or_absence denotes -
T25924 18345-18346 SO_EXT:normal_or_wild_type_or_present denotes +
T25923 18340-18345 PR_EXT:000013524 denotes Pygo2
T25922 18338-18339 SO_EXT:sequence_nullness_or_absence denotes -
T25921 18336-18337 SO_EXT:sequence_nullness_or_absence denotes -
T25920 18331-18336 PR_EXT:000013523 denotes Pygo1
T25919 18318-18319 SO_EXT:normal_or_wild_type_or_present denotes +
T25918 18316-18317 SO_EXT:normal_or_wild_type_or_present denotes +
T25917 18311-18316 PR_EXT:000013524 denotes Pygo2
T25916 18309-18310 SO_EXT:sequence_nullness_or_absence denotes -
T25915 18307-18308 SO_EXT:normal_or_wild_type_or_present denotes +
T25914 18302-18307 PR_EXT:000013523 denotes Pygo1
T25913 18273-18281 UBERON:0000056 denotes ureteric
T25912 18227-18234 UBERON:0002113 denotes kidneys
T25911 18211-18212 SO_EXT:sequence_nullness_or_absence denotes -
T25910 18209-18210 SO_EXT:sequence_nullness_or_absence denotes -
T25909 18204-18209 PR_EXT:000013524 denotes Pygo2
T25908 18202-18203 SO_EXT:sequence_nullness_or_absence denotes -
T25907 18200-18201 SO_EXT:sequence_nullness_or_absence denotes -
T25906 18195-18200 PR_EXT:000013523 denotes Pygo1
T25905 18179-18180 SO_EXT:sequence_nullness_or_absence denotes -
T25904 18177-18178 SO_EXT:normal_or_wild_type_or_present denotes +
T25903 18172-18177 PR_EXT:000013524 denotes Pygo2
T25902 18170-18171 SO_EXT:sequence_nullness_or_absence denotes -
T25901 18168-18169 SO_EXT:sequence_nullness_or_absence denotes -
T25900 18163-18168 PR_EXT:000013523 denotes Pygo1
T25899 18153-18154 SO_EXT:normal_or_wild_type_or_present denotes +
T25898 18151-18152 SO_EXT:normal_or_wild_type_or_present denotes +
T25897 18146-18151 PR_EXT:000013524 denotes Pygo2
T25896 18144-18145 SO_EXT:sequence_nullness_or_absence denotes -
T25895 18142-18143 SO_EXT:normal_or_wild_type_or_present denotes +
T25894 18137-18142 PR_EXT:000013523 denotes Pygo1
T25893 18124-18131 SO_EXT:sequence_altered_entity denotes mutants
T25892 18032-18039 UBERON:0000958 denotes medulla
T25891 18021-18027 UBERON:0001851 denotes cortex
T25890 17989-17997 UBERON:0000056 denotes ureteric
T25889 17962-17972 GO:0010467 denotes expression
T25888 17949-17952 GO_EXT:0015925 denotes gal
T25887 17915-17922 UBERON:0002113 denotes kidneys
T25886 17902-17909 UBERON:0002113 denotes kidneys
T25885 17886-17887 SO_EXT:sequence_nullness_or_absence denotes -
T25884 17884-17885 SO_EXT:sequence_nullness_or_absence denotes -
T25883 17879-17884 PR_EXT:000013524 denotes Pygo2
T25882 17877-17878 SO_EXT:sequence_nullness_or_absence denotes -
T25881 17875-17876 SO_EXT:sequence_nullness_or_absence denotes -
T25880 17870-17875 PR_EXT:000013523 denotes Pygo1
T25879 17857-17858 SO_EXT:sequence_nullness_or_absence denotes -
T25878 17855-17856 SO_EXT:normal_or_wild_type_or_present denotes +
T25877 17850-17855 PR_EXT:000013524 denotes Pygo2
T25876 17848-17849 SO_EXT:sequence_nullness_or_absence denotes -
T25875 17846-17847 SO_EXT:normal_or_wild_type_or_present denotes +
T25874 17841-17846 PR_EXT:000013523 denotes Pygo1
T25873 17827-17832 CL_GO_EXT:cell denotes cells
T25872 17763-17770 UBERON:0002113 denotes kidneys
T25871 17724-17732 UBERON:0000056 denotes ureteric
T25870 17713-17719 UBERON:0000056 denotes ureter
T25869 17662-17682 UBERON:0003890 denotes paramesonephric duct
T25868 17625-17626 SO_EXT:sequence_nullness_or_absence denotes -
T25867 17623-17624 SO_EXT:sequence_nullness_or_absence denotes -
T25866 17618-17623 PR_EXT:000013524 denotes Pygo2
T25865 17616-17617 SO_EXT:sequence_nullness_or_absence denotes -
T25864 17614-17615 SO_EXT:sequence_nullness_or_absence denotes -
T25863 17609-17614 PR_EXT:000013523 denotes Pygo1
T25862 17581-17601 UBERON:0003890 denotes paramesonephric duct
T25861 17563-17571 UBERON:0000056 denotes ureteric
T25860 17549-17559 GO:0010467 denotes expression
T25859 17491-17492 SO_EXT:sequence_nullness_or_absence denotes -
T25858 17489-17490 SO_EXT:normal_or_wild_type_or_present denotes +
T25857 17484-17489 PR_EXT:000013524 denotes Pygo2
T25856 17482-17483 SO_EXT:sequence_nullness_or_absence denotes -
T25855 17480-17481 SO_EXT:normal_or_wild_type_or_present denotes +
T25854 17475-17480 PR_EXT:000013523 denotes Pygo1
T25853 17464-17470 UBERON:0002113 denotes kidney
T25852 17446-17456 GO:0010467 denotes expression
T25851 17432-17440 UBERON:0000056 denotes ureteric
T25850 17364-17384 UBERON:0003890 denotes paramesonephric duct
T25849 17346-17356 GO:0010467 denotes expression
T25848 17304-17305 SO_EXT:sequence_nullness_or_absence denotes -
T25847 17302-17303 SO_EXT:normal_or_wild_type_or_present denotes +
T25846 17297-17302 PR_EXT:000013524 denotes Pygo2
T25845 17295-17296 SO_EXT:sequence_nullness_or_absence denotes -
T25844 17293-17294 SO_EXT:sequence_nullness_or_absence denotes -
T25843 17288-17293 PR_EXT:000013523 denotes Pygo1
T25842 17266-17274 UBERON:0000056 denotes ureteric
T25841 17223-17243 UBERON:0003890 denotes paramesonephric duct
T25840 17205-17215 GO:0010467 denotes expression
T25839 17188-17189 SO_EXT:sequence_nullness_or_absence denotes -
T25838 17186-17187 SO_EXT:normal_or_wild_type_or_present denotes +
T25837 17181-17186 PR_EXT:000013524 denotes Pygo2
T25836 17179-17180 SO_EXT:sequence_nullness_or_absence denotes -
T25835 17177-17178 SO_EXT:normal_or_wild_type_or_present denotes +
T25834 17172-17177 PR_EXT:000013523 denotes Pygo1
T25833 17146-17154 UBERON:0000056 denotes ureteric
T25832 17117-17120 GO_EXT:0015925 denotes gal
T25831 17085-17086 SO_EXT:sequence_nullness_or_absence denotes -
T25830 17083-17084 SO_EXT:sequence_nullness_or_absence denotes -
T25829 17078-17083 PR_EXT:000013524 denotes Pygo2
T25828 17076-17077 SO_EXT:sequence_nullness_or_absence denotes -
T25827 17074-17075 SO_EXT:normal_or_wild_type_or_present denotes +
T25826 17069-17074 PR_EXT:000013523 denotes Pygo1
T25825 17057-17063 UBERON:0000056 denotes ureter
T25824 17038-17046 UBERON:0000056 denotes ureteric
T25823 17023-17036 UBERON:0006364 denotes ureteric tips
T25822 17001-17007 UBERON:0002113 denotes kidney
T25821 16962-16970 UBERON:0000056 denotes ureteric
T25820 16933-16936 GO_EXT:0015925 denotes gal
T25819 16921-16922 SO_EXT:normal_or_wild_type_or_present denotes +
T25818 16919-16920 SO_EXT:normal_or_wild_type_or_present denotes +
T25817 16914-16919 PR_EXT:000013524 denotes Pygo2
T25816 16912-16913 SO_EXT:sequence_nullness_or_absence denotes -
T25815 16910-16911 SO_EXT:normal_or_wild_type_or_present denotes +
T25814 16905-16910 PR_EXT:000013523 denotes Pygo1
T25813 16872-16890 GO_EXT:0004565 denotes beta-galactosidase
T25812 16837-16839 SO_EXT:transgenic_entity denotes Tg
T25811 16822-16831 SO_EXT:0000902 denotes transgene
T25810 16818-16821 GO_EXT:0015925 denotes gal
T25809 16795-16801 UBERON:0000922 denotes embryo
T25808 16764-16774 UBERON:0004122 denotes urogenital
T25807 16744-16749 CHEBI:75055 denotes X-gal
T25806 16693-16705 UBERON:0000084 denotes ureteric bud
T25805 16661-16673 UBERON:0009201 denotes nephric duct
T25804 16638-16648 GO:0010467 denotes expression
T25803 16616-16622 UBERON:0000922 denotes embryo
T25802 16614-16615 SO_EXT:sequence_nullness_or_absence denotes -
T25801 16612-16613 SO_EXT:sequence_nullness_or_absence denotes -
T25800 16608-16612 PR_EXT:000013524 denotes Pygo
T25799 16606-16607 SO_EXT:sequence_nullness_or_absence denotes -
T25798 16604-16605 SO_EXT:sequence_nullness_or_absence denotes -
T25797 16599-16604 PR_EXT:000013523 denotes Pygo1
T25796 16567-16579 UBERON:0000084 denotes ureteric bud
T25795 16532-16544 UBERON:0009201 denotes nephric duct
T24237 15225-15232 UBERON:0000922 denotes embryos
T24236 15131-15138 UBERON:0000922 denotes Embryos
T24235 15106-15129 GO:0060070 denotes canonical Wnt signaling
T24234 15074-15084 GO:0010467 denotes expression
T24233 15070-15073 GO_EXT:0015925 denotes gal
T24232 15030-15037 UBERON:0000922 denotes embryos
T24231 15028-15029 SO_EXT:sequence_nullness_or_absence denotes -
T24230 15026-15027 SO_EXT:sequence_nullness_or_absence denotes -
T24229 15021-15026 PR_EXT:000013524 denotes Pygo2
T24228 15019-15020 SO_EXT:sequence_nullness_or_absence denotes -
T24227 15017-15018 SO_EXT:sequence_nullness_or_absence denotes -
T24226 15012-15017 PR_EXT:000013523 denotes Pygo1
T24225 15005-15011 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T24224 14971-14981 GO:0010467 denotes expression
T24223 14967-14970 GO_EXT:0015925 denotes gal
T24222 14941-14947 SO_EXT:0001023 denotes allele
T24221 14935-14940 PR_EXT:000013524 denotes Pygo2
T24220 14925-14934 SO_EXT:wild_type_entity_or_quality denotes wild-type
T24219 14908-14915 SO_EXT:0001023 denotes alleles
T24218 14902-14907 PR_EXT:000013523 denotes Pygo1
T24217 14885-14893 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T24216 14872-14878 UBERON:0000922 denotes embryo
T24215 14870-14871 SO_EXT:sequence_nullness_or_absence denotes -
T24214 14868-14869 SO_EXT:normal_or_wild_type_or_present denotes +
T24213 14863-14868 PR_EXT:000013524 denotes Pygo2
T24212 14861-14862 SO_EXT:sequence_nullness_or_absence denotes -
T24211 14859-14860 SO_EXT:sequence_nullness_or_absence denotes -
T24210 14854-14859 PR_EXT:000013523 denotes Pygo1
T24209 14841-14848 UBERON:0002329 denotes somites
T24208 14823-14835 UBERON:0003051 denotes otic vesicle
T24207 14803-14821 UBERON:0004117 denotes pharyngeal pouches
T24206 14751-14761 GO:0010467 denotes expression
T24205 14738-14741 GO_EXT:0015925 denotes gal
T24204 14695-14702 SO_EXT:0001023 denotes alleles
T24203 14689-14694 PR_EXT:000013524 denotes Pygo2
T24202 14662-14669 UBERON:0000922 denotes embryos
T24201 14660-14661 SO_EXT:sequence_nullness_or_absence denotes -
T24200 14658-14659 SO_EXT:sequence_nullness_or_absence denotes -
T24199 14653-14658 PR_EXT:000013524 denotes Pygo2
T24198 14651-14652 SO_EXT:sequence_nullness_or_absence denotes -
T24197 14649-14650 SO_EXT:normal_or_wild_type_or_present denotes +
T24180 14453-14458 PR_EXT:000013523 denotes Pygo1
T24179 14424-14447 GO:0060070 denotes canonical Wnt signaling
T24178 14402-14411 SO_EXT:0000902 denotes transgene
T24177 14398-14401 GO_EXT:0015925 denotes gal
T24176 14372-14379 UBERON:0000922 denotes embryos
T24175 14357-14364 UBERON:0000922 denotes embryos
T24174 14350-14356 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T24173 14344-14349 PR_EXT:000013524 denotes Pygo2
T24172 14338-14343 PR_EXT:000013523 denotes Pygo1
T24171 14328-14333 PR_EXT:000013524 denotes Pygo2
T24170 14301-14324 GO:0060070 denotes canonical Wnt signaling
T23565 13597-13602 PR_EXT:000017438 denotes Wnt11
T23564 13568-13581 UBERON:0006364 denotes ureteric tips
T23563 13538-13543 PR_EXT:000017453 denotes Wnt9b
T23562 13528-13533 PR_EXT:000017449 denotes Wnt7b
T23561 13520-13527 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T23560 13505-13519 UBERON:0012238 denotes ureteric stalk
T23559 13477-13487 GO:0010467 denotes expression
T23558 13455-13462 UBERON:0002113 denotes kidneys
T23557 13448-13454 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T23556 13437-13442 PR_EXT:000017438 denotes Wnt11
T23555 13419-13424 PR_EXT:000017453 denotes Wnt9b
T23554 13405-13410 PR_EXT:000017449 denotes Wnt7b
T23553 13389-13396 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T23552 13365-13377 UBERON:0000084 denotes ureteric bud
T23551 13348-13355 UBERON:0002113 denotes kidneys
T23550 13341-13347 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T23549 13339-13340 SO_EXT:sequence_nullness_or_absence denotes -
T23548 13337-13338 SO_EXT:sequence_nullness_or_absence denotes -
T23547 13332-13337 PR_EXT:000013524 denotes Pygo2
T23546 13330-13331 SO_EXT:sequence_nullness_or_absence denotes -
T23545 13328-13329 SO_EXT:sequence_nullness_or_absence denotes -
T23544 13323-13328 PR_EXT:000013523 denotes Pygo1
T23543 13305-13312 UBERON:0002113 denotes kidneys
T23542 13295-13304 SO_EXT:wild_type_entity_or_quality denotes wild-type
T23541 13265-13279 GO:0097617 denotes hybridizations
T23540 13233-13240 UBERON:0002113 denotes kidneys
T23539 13228-13232 SO_EXT:sequence_nullness denotes null
T23538 13213-13218 PR_EXT:000013524 denotes Pygo2
T23537 13207-13212 PR_EXT:000013523 denotes Pygo1
T23536 13192-13197 PR_EXT:000017438 denotes Wnt11
T23535 13181-13186 PR_EXT:000017453 denotes Wnt9b
T23534 13174-13179 PR_EXT:000017449 denotes Wnt7b
T23533 13160-13170 GO:0010467 denotes Expression
T23090 10356-10361 PR_EXT:000013524 denotes Pygo2
T23116 11050-11057 SO_EXT:sequence_altered_entity denotes mutants
T23115 10998-11010 UBERON:0000084 denotes ureteric bud
T23114 10971-10981 UBERON:0003104 denotes mesenchyme
T23113 10925-10932 SO_EXT:sequence_altered_entity denotes mutants
T23112 10920-10924 SO_EXT:sequence_nullness denotes null
T23111 10912-10917 PR_EXT:000013523 denotes Pygo1
T23110 10867-10884 UBERON:0006364 denotes ureteric bud tips
T23109 10804-10811 UBERON:0002113 denotes kidneys
T23108 10799-10803 SO_EXT:sequence_nullness denotes null
T23107 10793-10798 PR_EXT:000013524 denotes Pygo2
T23106 10787-10792 PR_EXT:000013523 denotes Pygo1
T23105 10737-10750 UBERON:0006364 denotes ureteric tips
T23104 10638-10646 UBERON:0000056 denotes ureteric
T23103 10592-10601 UBERON:0000483 denotes epithelia
T23102 10582-10588 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T23101 10566-10570 PR_EXT:000001447 denotes Cdh1
T23100 10522-10544 UBERON:0003220 denotes metanephric mesenchyme
T23099 10494-10503 GO:0010467 denotes expressed
T23098 10484-10487 PR_EXT:000017459 denotes Wt1
T23097 10467-10473 PR_EXT:000005505 denotes Cited1
T23096 10446-10456 GO:0042571 denotes antibodies
T23095 10397-10404 UBERON:0002113 denotes kidneys
T23094 10378-10385 UBERON:0002113 denotes kidneys
T23093 10365-10371 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T23092 10363-10364 SO_EXT:sequence_nullness_or_absence denotes -
T23091 10361-10362 SO_EXT:sequence_nullness_or_absence denotes -
T22636 9426-9434 GO:0042571 denotes antibody
T22635 9415-9425 PR_EXT:000001447 denotes E-cadherin
T22634 9396-9403 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T22633 9359-9371 UBERON:0000084 denotes ureteric bud
T22632 9342-9347 CL_GO_EXT:cell denotes cells
T22631 9331-9347 CL:0000066 denotes Epithelial cells
T22630 9331-9341 UBERON:0000483 denotes Epithelial
T22629 9304-9308 CL_GO_EXT:cell denotes cell
T22628 9296-9308 CL:0000499 denotes stromal cell
T22627 9296-9303 UBERON:0003891 denotes stromal
T22626 9256-9262 UBERON:0002113 denotes kidney
T22625 9187-9197 GO:0010467 denotes expression
T22624 9163-9168 SO_EXT:0000704 denotes genes
T22623 9136-9143 GO:0005634 denotes nucleus
T22622 9119-9128 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T22621 9102-9107 PR_EXT:000013524 denotes Pygo2
T22620 9092-9097 PR_EXT:000013523 denotes Pygo1
T22619 9079-9085 UBERON:0001225 denotes kidney
T22618 9059-9068 _FRAGMENT denotes cortex of
T22617 9043-9051 CHEBI_PR_EXT:protein denotes proteins
T22616 9037-9042 PR_EXT:000013524 denotes Pygo2
T22615 9027-9032 PR_EXT:000013523 denotes Pygo1
T22614 9000-9010 GO:0010467 denotes expression
T22613 8951-8957 UBERON:0002113 denotes kidney
T22612 8916-8926 GO:0010467 denotes expression
T22611 8910-8915 PR_EXT:000013524 denotes Pygo2
T22610 8900-8905 PR_EXT:000013523 denotes Pygo1
T21828 44522-44525 CHEBI_SO_EXT:RNA denotes RNA
T21191 44438-44443 SO_EXT:0000704 denotes genes
T21190 44281-44286 SO_EXT:0000704 denotes Genes
T21189 44130-44135 CHEBI_SO_EXT:molecular_probe denotes probe
T21188 44076-44086 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T21187 44051-44058 UBERON:0002113 denotes kidneys
T21186 44041-44050 SO_EXT:wild_type_entity_or_quality denotes wild-type
T21185 44025-44029 SO_EXT:sequence_nullness denotes null
T21184 44019-44024 PR_EXT:000013524 denotes Pygo2
T21183 44013-44018 PR_EXT:000013523 denotes Pygo1
T21182 43955-43959 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes tags
T21181 43936-43959 SO_EXT:0000345 denotes expressed sequence tags
T21180 43936-43945 GO:0010467 denotes expressed
T21179 43926-43931 SO_EXT:0000704 denotes genes
T21178 43847-43857 GO:0010467 denotes expression
T21177 43839-43844 NCBITaxon:10088 denotes Mouse
T21176 43804-43814 GO:0097617 denotes hybridized
T21175 43796-43799 CHEBI_SO_EXT:RNA denotes RNA
T21174 43788-43795 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes Labeled
T21173 43688-43695 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T21172 43666-43669 CHEBI_SO_EXT:RNA denotes RNA
T21171 43598-43601 CHEBI_SO_EXT:RNA denotes RNA
T21170 43544-43551 UBERON:0000922 denotes embryos
T21169 43539-43543 SO_EXT:sequence_nullness denotes null
T21168 43524-43529 PR_EXT:000013524 denotes Pygo2
T21167 43518-43523 PR_EXT:000013523 denotes Pygo1
T21166 43484-43491 UBERON:0002113 denotes kidneys
T21165 43456-43459 CHEBI_SO_EXT:RNA denotes RNA
T20632 43411-43412 SO_EXT:sequence_nullness_or_absence denotes -
T20631 43409-43410 SO_EXT:sequence_nullness_or_absence denotes -
T20630 43404-43409 PR_EXT:000013524 denotes Pygo2
T20629 43400-43401 SO_EXT:sequence_nullness_or_absence denotes -
T20068 42738-42744 UBERON:0000922 denotes embryo
T20067 42731-42737 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T20066 42705-42710 PR_EXT:000013523 denotes Pygo1
T20065 42662-42672 GO:0042571 denotes antibodies
T20064 42628-42636 GO:0042571 denotes antibody
T20063 42602-42608 CHEBI_CHMO_EXT:buffer_solution denotes buffer
T20062 42567-42576 GO:0042571 denotes antibodes
T20061 42561-42566 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bound
T20060 42518-42524 PR_EXT:Q9D0P5 denotes mPygo1
T20059 42514-42517 GO_PR_EXT:glutathione_S_transferase denotes GST
T20058 42504-42510 PR_EXT:Q9BRQ0 denotes hPygo2
T20057 42500-42503 GO_PR_EXT:glutathione_S_transferase denotes GST
T20056 42488-42492 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T20055 42453-42456 GO_PR_EXT:glutathione_S_transferase denotes GST
T20054 42419-42423 UBERON:0001977 denotes sera
T20053 42408-42414 PR_EXT:Q9D0P5 denotes mPygo1
T20052 42392-42398 PR_EXT:Q9BRQ0 denotes hPygo2
T20051 42378-42381 GO_PR_EXT:glutathione_S_transferase denotes GST
T20050 42359-42369 GO:0042571 denotes antibodies
T20049 42325-42328 GO_PR_EXT:glutathione_S_transferase denotes GST
T20048 42313-42317 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T20047 42280-42286 PR_EXT:Q9BRQ0 denotes hPygo2
T20046 42264-42270 PR_EXT:Q9D0P5 denotes mPygo1
T20045 42251-42255 UBERON:0001977 denotes sera
T20044 42240-42246 NCBITaxon:9986 denotes rabbit
T20043 42169-42188 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes antibody production
T20042 42169-42177 GO:0042571 denotes antibody
T20041 42157-42164 NCBITaxon:9986 denotes rabbits
T20040 42119-42127 NCBITaxon:2 denotes bacteria
T20039 42106-42115 GO:0010467 denotes expressed
T20038 42092-42100 CHEBI_PR_EXT:protein denotes proteins
T20037 42085-42091 PR_EXT:Q9D0P5 denotes mPygo1
T20036 42081-42084 GO_PR_EXT:glutathione_S_transferase denotes GST
T20035 42070-42076 PR_EXT:Q9BRQ0 denotes hPygo2
T20034 42066-42069 GO_PR_EXT:glutathione_S_transferase denotes GST
T20033 42058-42064 PR_EXT:Q9D0P5 denotes mPygo1
T20032 42047-42053 PR_EXT:Q9BRQ0 denotes hPygo2
T20031 42026-42035 SO_EXT:biological_conservation_process_or_quality denotes conserved
T20030 41996-42003 PR_EXT:Q9D0P5 denotes mPygo 1
T20029 41984-41991 PR_EXT:Q9BRQ0 denotes hPygo 2
T20028 41904-41909 PR_EXT:000013523 denotes Pygo1
T20027 41898-41903 NCBITaxon:10088 denotes mouse
T20026 41879-41887 CHEBI_EXT:residue denotes residues
T20025 41868-41878 CHEBI_SO_EXT:amino_acid denotes amino-acid
T19483 41552-41557 PR_EXT:000017449 denotes Wnt7b
T19482 41542-41547 PR_EXT:000017438 denotes Wnt11
T19481 41528-41538 CHEBI_SO_EXT:riboprobe denotes Riboprobes
T19480 41470-41483 GO:0097617 denotes hybridization
T19479 41436-41449 GO:0097617 denotes hybridization
T19093 40818-40828 MOP:0000779 denotes conjugated
T19092 40797-40803 NCBITaxon:9986 denotes rabbit
T19091 40781-40791 MOP:0000779 denotes conjugated
T19090 40771-40780 CHEBI:52673 denotes Alexa 555
T19089 40755-40765 GO:0042571 denotes antibodies
T19088 40679-40685 PR_EXT:000005505 denotes Cited1
T19087 40629-40633 PR_EXT:000001447 denotes Cdh1
T19086 40617-40627 PR_EXT:000001447 denotes e-cadherin
T19085 40605-40615 PR_EXT:000001447 denotes uvomorulin
T19084 40541-40544 PR_EXT:000017459 denotes WT1
T19083 40520-40530 GO:0042571 denotes antibodies
T19082 40496-40506 GO:0042571 denotes antibodies
T19081 40456-40461 UBERON:0001977 denotes serum
T19080 40451-40455 NCBITaxon:9925 denotes goat
T19079 40373-40390 NCBITaxon:271171 denotes Dilichos biflorus
T19078 40362-40372 MOP:0000779 denotes conjugated
T19077 40350-40361 CHEBI:31624 denotes fluoroscein
T19076 40337-40344 UBERON:0000479 denotes tissues
T19075 40303-40304 CHEBI:53424 denotes T
T19074 40287-40297 GO:0042571 denotes antibodies
T19073 40248-40249 CHEBI:53424 denotes T
T19072 40234-40242 CHEBI:53424 denotes Tween-20
T19071 40193-40201 CHEBI:17790 denotes methanol
T19070 40162-40178 CHEBI_EXT:paraformaldehye denotes paraformaldehyde
T19069 40129-40136 UBERON:0002113 denotes Kidneys
T18157 39582-39588 GO:0007618 denotes mating
T18156 39558-39563 PR_EXT:000013524 denotes Pygo2
T18155 39548-39553 PR_EXT:000013523 denotes Pygo1
T18154 39532-39539 SO_EXT:0001023 denotes alleles
T18153 39527-39531 SO_EXT:sequence_nullness denotes null
T18152 39438-39442 NCBITaxon:10088 denotes mice
T18151 39415-39420 GO:0007618 denotes mated
T18150 39336-39346 UBERON:0000358 denotes blastocyst
T18149 39313-39318 CL_GO_EXT:cell denotes cells
T18148 39310-39318 CL:0002322 denotes ES cells
T18147 39280-39285 CL_GO_EXT:cell denotes cells
T18146 39277-39285 CL:0002322 denotes ES cells
T18145 39238-39248 SO_EXT:engineered_biological_sequence denotes constructs
T18144 39227-39237 SO_EXT:sequence_linearization denotes Linearized
T18143 39170-39179 SO_EXT:biological_sequence denotes sequences
T18142 39165-39169 SO_EXT:0000147 denotes exon
T18141 39027-39036 SO_EXT:biological_sequence denotes sequences
T18140 39019-39026 SO_EXT:0001026 denotes genomic
T18139 39008-39013 PR_EXT:000013524 denotes Pygo2
T18138 38976-38980 SO:0001031 denotes back
T18137 38940-38947 SO:0001030 denotes forward
T18136 38907-38911 SO:0001031 denotes back
T18135 38902-38906 SO_EXT:0000147 denotes exon
T18134 38871-38878 SO:0001030 denotes forward
T18133 38866-38870 SO_EXT:0000147 denotes exon
T18132 38837-38841 SO:0001031 denotes back
T18131 38799-38806 SO:0001030 denotes forward
T18130 38767-38776 SO_EXT:biological_sequence denotes sequences
T18129 38759-38766 SO_EXT:0001026 denotes genomic
T18128 38748-38753 PR_EXT:000013523 denotes Pygo1
T18127 38703-38713 SO_EXT:engineered_biological_sequence denotes constructs
T18126 38674-38677 CHEBI_SO_EXT:DNA denotes DNA
T18125 38669-38673 CL_GO_EXT:cell denotes cell
T18124 38666-38673 CL:0002322 denotes ES cell
T18123 38600-38607 SO_EXT:0001026 denotes genomic
T18122 38579-38588 SO_EXT:engineered_biological_sequence denotes construct
T18121 38554-38568 SO_EXT:0000346 denotes LoxP sequences
T18120 38543-38550 SO:0000357 denotes flanked
T18119 38498-38511 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T18118 38426-38443 SO_EXT:0000061 denotes restriction sites
T18117 38394-38407 SO_EXT:0000350 denotes FRT sequences
T18116 38383-38390 SO:0000357 denotes flanked
T18115 38378-38382 SO_EXT:0000704 denotes gene
T18114 38358-38366 CHEBI:7507 denotes neomycin
T18113 38308-38314 SO_EXT:0000440 denotes vector
T18112 38300-38303 PR_EXT:P03870 denotes Flp
T18111 38269-38279 SO_EXT:engineered_biological_sequence denotes constructs
T18110 38243-38257 SO_EXT:0000346 denotes LoxP sequences
T18109 38232-38237 SO_EXT:sequence_or_structure_motif denotes motif
T18108 38208-38212 SO_EXT:0001215 denotes exon
T18107 38180-38197 _FRAGMENT denotes coding regions of
T18106 38158-38166 SO:0000357 denotes flanking
T18105 38130-38135 SO_EXT:0000704 denotes genes
T18104 38124-38129 PR_EXT:000013524 denotes Pygo2
T18103 38114-38119 PR_EXT:000013523 denotes Pygo1
T18102 38108-38113 PR_EXT:000013524 denotes Pygo2
T18101 38098-38103 PR_EXT:000013523 denotes Pygo1
T18188 40059-40072 UBERON:0010148 denotes vaginal plugs
T18187 40008-40009 SO:0001031 denotes R
T18186 39978-39979 SO:0001030 denotes F
T18185 39970-39976 SO_EXT:0001023 denotes allele
T18184 39963-39969 SO:0000359 denotes floxed
T18183 39957-39959 SO_EXT:wild_type_entity_or_quality denotes WT
T18182 39951-39956 PR_EXT:000013523 denotes Pygo1
T18181 39923-39924 SO:0001031 denotes R
T18180 39894-39895 SO:0001030 denotes F
T18179 39886-39892 SO_EXT:0001023 denotes allele
T18178 39881-39885 SO_EXT:sequence_nullness denotes null
T18177 39875-39880 PR_EXT:000013523 denotes Pygo1
T18176 39847-39848 SO:0001031 denotes R
T18175 39820-39821 SO:0001030 denotes F
T18174 39812-39818 SO_EXT:0001023 denotes allele
T18173 39805-39811 SO:0000359 denotes floxed
T18172 39799-39801 SO_EXT:wild_type_entity_or_quality denotes WT
T18171 39793-39798 PR_EXT:000013524 denotes Pygo2
T18170 39766-39767 SO:0001031 denotes R
T18169 39757-39764 SO:0001031 denotes reverse
T18168 39729-39730 SO:0001030 denotes F
T18167 39720-39727 SO:0001030 denotes forward
T18166 39712-39718 SO_EXT:0001023 denotes allele
T18165 39707-39711 SO_EXT:sequence_nullness denotes null
T18164 39701-39706 PR_EXT:000013524 denotes Pygo2
T18163 39663-39670 SO_EXT:0000112 denotes primers
T18162 39646-39655 SO_EXT:biological_sequence denotes sequences
T18161 39631-39635 NCBITaxon:10088 denotes mice
T18160 39623-39626 NCBITaxon:10358 denotes CMV
T18159 39609-39613 NCBITaxon:10088 denotes mice
T18158 39602-39608 SO:0000359 denotes floxed
T17128 38044-38049 SO_EXT:0000704 denotes genes
T17127 38026-38033 PR_EXT:Q9V9W8 denotes Pygopus
T17126 37983-37990 NCBITaxon:40674 denotes mammals
T17125 37974-37979 PR_EXT:000013524 denotes Pygo2
T17124 37968-37973 PR_EXT:000013523 denotes Pygo1
T17123 37930-37943 GO_EXT:transcription denotes transcription
T17122 37910-37922 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T17121 37902-37909 GO:0005634 denotes nuclear
T17120 37863-37871 CHEBI_PR_EXT:protein denotes proteins
T17119 37795-37823 GO:0005667 denotes transcription-factor complex
T17118 37795-37815 GO_EXT:transcription_factor denotes transcription-factor
T17117 37795-37808 GO_EXT:transcription denotes transcription
T17116 37785-37794 PR_EXT:000002198 denotes β-catenin
T17115 37774-37779 SO_EXT:0000704 denotes genes
T17114 37766-37773 PR_EXT:Q9V9W8 denotes Pygopus
T17113 37712-37717 SO_EXT:0000704 denotes genes
T17112 37697-37704 NCBITaxon:40674 denotes mammals
T17111 37644-37651 SO_EXT:sequence_altered_entity denotes mutants
T17110 37636-37643 PR_EXT:Q9V9W8 denotes Pygopus
T17109 37603-37616 GO:0048513 denotes organogenesis
T17108 37593-37602 NCBITaxon:40674 denotes mammalian
T17107 37540-37553 GO:0016055 denotes Wnt signaling
T17106 37531-37536 SO_EXT:0000704 denotes genes
T17105 37524-37528 PR_EXT:000013523 denotes Pyg1
T17104 37480-37490 NCBITaxon:7215 denotes Drosophila
T17103 37447-37455 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T17102 37439-37446 PR_EXT:Q9V9W8 denotes Pygopus
T17101 37395-37402 NCBITaxon:40674 denotes mammals
T17100 37367-37390 GO:0060070 denotes canonical Wnt signaling
T17099 37330-37354 SO_EXT:biological_conservation_process_or_quality denotes evolutionarily conserved
T17098 37285-37289 NCBITaxon:10088 denotes mice
T17097 37270-37275 PR_EXT:000013524 denotes Pygo2
T17096 37264-37269 PR_EXT:000013523 denotes Pygo1
T17095 37246-37256 GO:0010467 denotes expression
T17094 37227-37236 SO_EXT:0000902 denotes transgene
T17093 37223-37226 GO_EXT:0015925 denotes gal
T17092 37174-37178 CL_GO_EXT:cell denotes cell
T17091 37150-37163 GO:0016055 denotes Wnt signaling
T17090 37154-37163 GO_EXT:0004871 denotes signaling
T17089 37135-37149 _FRAGMENT denotes transducers of
T17088 37108-37115 UBERON:0000467 denotes systems
T17087 37078-37083 SO_EXT:0000704 denotes genes
T17086 37070-37077 PR_EXT:Q9V9W8 denotes Pygopus
T17085 37060-37069 NCBITaxon:40674 denotes mammalian
T17084 37018-37031 GO:0001822 denotes nephrogenesis
T17083 36991-37014 GO:0060070 denotes canonical Wnt signaling
T17082 36957-36967 NCBITaxon:7215 denotes Drosophila
T17081 36930-36953 GO:0060070 denotes canonical Wnt signaling
T17080 36922-36926 SO_EXT:0000704 denotes gene
T17079 36914-36921 PR_EXT:Q9V9W8 denotes Pygopus
T17078 36851-36858 SO_EXT:sequence_altered_entity denotes mutants
T17077 36827-36832 PR_EXT:000013524 denotes Pygo2
T17076 36821-36826 PR_EXT:000013523 denotes Pygo1
T17075 36764-36781 GO:0072006 denotes nephron formation
T17074 36764-36771 UBERON:0001285 denotes nephron
T17073 36735-36748 UBERON:0000084 denotes ureteric buds
T17072 36698-36720 UBERON:0003220 denotes metanephric mesenchyme
T17071 36652-36659 SO_EXT:sequence_altered_entity denotes mutants
T17070 36646-36651 PR_EXT:000013524 denotes Pygo2
T17069 36572-36579 SO_EXT:sequence_altered_entity denotes mutants
T17068 36553-36565 UBERON:0000084 denotes ureteric bud
T17067 36553-36565 GO:0001658 denotes ureteric bud
T17066 36522-36548 _FRAGMENT denotes branching morphogenesis of
T17065 36494-36498 SO_EXT:0000704 denotes gene
T17064 36488-36493 PR_EXT:000013524 denotes Pygo2
T17063 36478-36487 NCBITaxon:40674 denotes mammalian
T15282 36195-36205 GO:0010467 denotes expression
T15281 36184-36189 SO_EXT:0000704 denotes genes
T15280 36168-36178 NCBITaxon:7215 denotes Drosophila
T15279 36111-36134 GO:0060070 denotes canonical Wnt signaling
T15278 36086-36093 NCBITaxon:40674 denotes mammals
T15277 36077-36082 SO_EXT:0000704 denotes genes
T15276 36069-36076 PR_EXT:Q9V9W8 denotes Pygopus
T15275 36031-36041 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T15274 35911-35921 GO:0010467 denotes expression
T15273 35886-35891 SO_EXT:0000704 denotes genes
T15272 35870-35879 SO_EXT:wild_type_entity_or_quality denotes wild type
T15271 35821-35836 GO:0010467 denotes gene-expression
T15270 35821-35825 SO_EXT:0000704 denotes gene
T15269 35806-35813 UBERON:0002113 denotes kidneys
T15268 35799-35805 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T15244 35078-35083 PR_EXT:000013523 denotes Pygo1
T15243 35004-35027 GO:0060070 denotes canonical Wnt signaling
T15242 34982-34991 SO_EXT:0000902 denotes transgene
T15241 34978-34981 GO_EXT:0015925 denotes gal
T15240 34945-34968 GO:0060070 denotes canonical Wnt signaling
T15239 34906-34911 SO_EXT:0000704 denotes genes
T15238 34900-34905 PR_EXT:000013524 denotes Pygo2
T15237 34894-34899 PR_EXT:000013523 denotes Pygo1
T15236 34882-34889 NCBITaxon:40674 denotes mammals
T15235 34848-34871 GO:0060070 denotes canonical Wnt signaling
T15234 34821-34825 SO_EXT:0000704 denotes gene
T15233 34813-34820 PR_EXT:Q9V9W8 denotes Pygopus
T15232 34797-34807 NCBITaxon:7215 denotes Drosophila
T15231 34785-34792 NCBITaxon:40674 denotes mammals
T15230 34770-34780 NCBITaxon:7215 denotes Drosophila
T15229 34745-34752 PR_EXT:Q9V9W8 denotes Pygopus
T15228 34627-34650 GO:0060070 denotes canonical Wnt signaling
T15227 34609-34622 GO:0001822 denotes nephrogenesis
T15226 34561-34583 UBERON:0003220 denotes metanephric mesenchyme
T15225 34541-34553 UBERON:0000084 denotes ureteric bud
T15224 34522-34531 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T15223 34516-34521 PR_EXT:000017453 denotes Wnt9b
T15222 34459-34467 UBERON:0001285 denotes nephrons
T15221 34429-34451 UBERON:0003220 denotes metanephric mesenchyme
T15220 34422-34428 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T15219 34390-34402 UBERON:0000084 denotes ureteric bud
T15218 34365-34375 UBERON:0003104 denotes mesenchyme
T15217 34307-34314 SO_EXT:sequence_altered_entity denotes mutants
T15216 34299-34304 PR_EXT:000013523 denotes Pygo1
T15215 34281-34293 UBERON:0000084 denotes ureteric bud
T15214 34260-34273 GO:0016055 denotes Wnt signaling
T15213 34229-34236 SO_EXT:sequence_altered_entity denotes mutants
T15212 34223-34228 PR_EXT:000013524 denotes Pygo2
T15211 34217-34222 PR_EXT:000013523 denotes Pygo1
T15210 34179-34189 UBERON:0003104 denotes mesenchyme
T15209 34155-34169 GO:0035860 denotes GDNF signaling
T15208 34155-34159 PR_EXT:000007928 denotes GDNF
T15207 34140-34150 UBERON:0003104 denotes mesenchyme
T15206 34120-34132 UBERON:0000084 denotes ureteric bud
T15205 34097-34110 GO:0016055 denotes Wnt signaling
T15204 34049-34056 SO_EXT:sequence_altered_entity denotes mutants
T15203 34043-34048 PR_EXT:000017438 denotes Wnt11
T15202 34005-34028 GO:0060070 denotes canonical Wnt signaling
T15201 33991-33996 SO_EXT:0000704 denotes genes
T15200 33983-33990 PR_EXT:Q9V9W8 denotes Pygopus
T15199 33861-33866 PR_EXT:000017438 denotes Wnt11
T15198 33785-33792 SO_EXT:sequence_altered_entity denotes mutants
T15197 33779-33784 PR_EXT:000017438 denotes Wnt11
T15196 33710-33722 UBERON:0000084 denotes ureteric bud
T15195 33710-33722 GO:0001658 denotes ureteric bud
T15194 33679-33705 _FRAGMENT denotes branching morphogenesis of
T15193 33651-33657 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T15192 33645-33650 PR_EXT:000013524 denotes Pygo2
T15191 33639-33644 PR_EXT:000013523 denotes Pygo1
T15190 33624-33633 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T15189 33611-33623 UBERON:0000084 denotes ureteric bud
T15188 33597-33607 UBERON:0003104 denotes mesenchyme
T15187 33559-33581 UBERON:0003220 denotes metanephric mesenchyme
T15186 33538-33551 GO:0016055 denotes Wnt signaling
T15185 33423-33435 UBERON:0000084 denotes ureteric bud
T15184 33402-33415 GO:0016055 denotes Wnt signaling
T15183 33344-33356 UBERON:0000084 denotes ureteric bud
T15182 33344-33356 GO:0001658 denotes ureteric bud
T15181 33313-33339 _FRAGMENT denotes branching morphogenesis of
T15180 33286-33309 GO:0060070 denotes canonical Wnt signaling
T15179 33255-33262 SO_EXT:sequence_altered_entity denotes mutants
T15178 33238-33246 UBERON:0000056 denotes ureteric
T15177 33196-33202 UBERON:0002113 denotes kidney
T15176 33166-33178 UBERON:0006364 denotes ureteric tip
T15175 33102-33115 GO:0016055 denotes Wnt signaling
T15174 33036-33043 SO_EXT:sequence_altered_entity denotes mutants
T15173 33030-33035 PR_EXT:000013524 denotes Pygo2
T15172 33006-33012 UBERON:0002113 denotes kidney
T15171 32955-32967 UBERON:0000084 denotes ureteric bud
T15170 32924-32947 GO:0060070 denotes canonical Wnt signaling
T15169 32879-32888 SO_EXT:0000902 denotes transgene
T15168 32875-32878 GO_EXT:0015925 denotes gal
T15167 32847-32865 GO:0001822 denotes kidney development
T15166 32847-32853 UBERON:0002113 denotes kidney
T15165 32768-32790 UBERON:0003220 denotes metanephric mesenchyme
T15164 32750-32760 GO:0010467 denotes expression
T15163 32745-32749 PR_EXT:000007928 denotes GDNF
T15162 32715-32732 UBERON:0006364 denotes ureteric bud tips
T15161 32690-32695 PR_EXT:000017438 denotes Wnt11
T15160 32658-32671 GO:0001822 denotes nephrogenesis
T15159 32609-32631 UBERON:0003220 denotes metanephric mesenchyme
T15158 32578-32582 PR_EXT:000017444 denotes Wnt4
T15157 32569-32574 PR_EXT:000017453 denotes Wnt9b
T15156 32536-32549 GO:0001822 denotes nephrogenesis
T15155 32502-32524 UBERON:0003220 denotes metanephric mesenchyme
T15154 32473-32485 UBERON:0000084 denotes ureteric bud
T15153 32452-32457 PR_EXT:000017453 denotes Wnt9b
T15152 32437-32450 GO:0001822 denotes nephrogenesis
T15151 32358-32371 GO:0016055 denotes Wnt signaling
T15150 32341-32347 UBERON:0002113 denotes kidney
T15149 32290-32297 SO_EXT:0001023 denotes alleles
T15148 32149-32160 CHEBI_SO_EXT:amino_acid denotes amino acids
T15147 32127-32133 SO_EXT:sequence_coding_function denotes coding
T15146 32119-32126 SO_EXT:sequence_deletion_process denotes deleted
T15144 32104-32109 PR_EXT:000013524 denotes Pygo2
T15143 32083-32090 SO_EXT:sequence_deletion_process denotes deleted
T15142 32067-32078 CHEBI_SO_EXT:amino_acid denotes amino acids
T15141 32032-32045 SO_EXT:coding_sequence denotes coding region
T15140 32022-32026 SO_EXT:0000704 denotes gene
T15139 32016-32021 PR_EXT:000013523 denotes Pygo1
T15138 31990-32006 SO_EXT:coding_sequence denotes coding sequences
T15137 31959-31966 SO_EXT:0000417 denotes domains
T15136 31931-31940 SO_EXT:sequence_deletion_entity_or_process denotes deletions
T15135 31895-31902 SO_EXT:0001023 denotes alleles
T15134 31888-31894 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T15133 31882-31887 PR_EXT:000013524 denotes Pygo2
T15132 31876-31881 PR_EXT:000013523 denotes Pygo1
T15131 31841-31866 GO:0007444 denotes imaginal disc development
T15130 31841-31854 UBERON:0000939 denotes imaginal disc
T15129 31823-31836 GO:0009790 denotes embryogenesis
T15128 31792-31805 GO:0016055 denotes Wnt signaling
T15127 31776-31784 CHEBI_SO_EXT:tyrosine denotes tyrosine
T15126 31764-31772 CHEBI_SO_EXT:cysteine denotes cysteine
T15125 31752-31758 SO_EXT:0000417 denotes domain
T15124 31726-31736 CHEBI_SO_EXT:amino_acid denotes amino acid
T15123 31715-31725 SO_EXT:sequence_alteration_process denotes converting
T15122 31706-31714 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T15121 31697-31705 SO_EXT:missense_quality_or_entity denotes missense
T15120 31675-31681 SO_EXT:0001023 denotes allele
T15119 31666-31670 PR_EXT:Pygo denotes pygo
T15118 31651-31661 NCBITaxon:7215 denotes Drosophila
T15117 31622-31629 CHEBI_PR_EXT:protein denotes protein
T15116 31614-31621 CHEBI_PR_EXT:protein denotes protein
T15115 31589-31609 GO:0006338 denotes chromatin remodeling
T15114 31589-31598 GO:0000785 denotes chromatin
T15113 31538-31559 GO_EXT:transcription_factor denotes transcription factors
T15112 31538-31551 GO_EXT:transcription denotes transcription
T15111 31518-31526 CHEBI_PR_EXT:protein denotes proteins
T15110 31489-31496 SO_EXT:0000417 denotes domains
T15109 31474-31483 CHEBI:27365 denotes zinc ions
T15108 31462-31469 GO_MOP_EXT:metal_chelation denotes chelate
T15107 31438-31447 CHEBI_SO_EXT:histidine denotes histidine
T15106 31422-31431 CHEBI_SO_EXT:cysteine denotes cysteines
T15105 31399-31410 CHEBI_SO_EXT:amino_acid denotes amino acids
T15104 31386-31392 SO_EXT:0000417 denotes domain
T15103 31367-31376 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T15102 31364-31366 PR_EXT:000017435 denotes Wg
T15101 31344-31351 PR_EXT:Q9V9W8 denotes Pygopus
T15100 31309-31315 SO_EXT:0000417 denotes domain
T15099 31266-31276 NCBITaxon:7215 denotes Drosophila
T15098 31256-31261 SO_EXT:null_sequence_entity denotes nulls
T15097 31181-31188 SO_EXT:0001023 denotes alleles
T15096 31172-31180 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T15095 31164-31171 PR_EXT:Q9V9W8 denotes Pygopus
T15094 31153-31158 SO_EXT:0000704 denotes genes
T15093 31147-31152 PR_EXT:000013524 denotes Pygo2
T15092 31137-31142 PR_EXT:000013523 denotes Pygo1
T15091 31090-31094 SO_EXT:0000704 denotes gene
T15090 31005-31015 GO:0010467 denotes expression
T15089 30952-30955 GO_EXT:0015925 denotes gal
T15088 30936-30943 UBERON:0000479 denotes tissues
T15087 30908-30914 SO_EXT:sequence_altered_entity denotes mutant
T15086 30902-30907 PR_EXT:000013524 denotes Pygo2
T15085 30896-30901 PR_EXT:000013523 denotes Pygo1
T15084 30787-30794 SO_EXT:sequence_altered_entity denotes mutants
T15083 30770-30775 PR_EXT:000013523 denotes Pygo1
T15082 30724-30729 GO:0007567 denotes birth
T15081 30703-30710 SO_EXT:sequence_altered_entity denotes mutants
T15080 30697-30702 PR_EXT:000013524 denotes Pygo2
T15079 30672-30681 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T15078 30666-30671 PR_EXT:000013524 denotes Pygo2
T15077 30660-30665 PR_EXT:000013523 denotes Pygo1
T15076 30643-30648 PR_EXT:000013524 denotes Pygo2
T15075 30636-30641 PR_EXT:000013523 denotes Pygo1
T15074 30617-30621 NCBITaxon:10088 denotes mice
T15073 30571-30581 NCBITaxon:7215 denotes Drosophila
T15072 30513-30540 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signal transduction pathway
T15071 30510-30512 PR_EXT:000017435 denotes Wg
T15070 30472-30476 PR_EXT:Pygo denotes Pygo
T15069 30431-30450 GO:0007507 denotes cardiac development
T15068 30431-30438 UBERON:0000948 denotes cardiac
T15067 30439-30450 GO:0007417 denotes development
T15066 30403-30425 _FRAGMENT denotes central nervous system
T15065 30403-30425 UBERON:0001017 denotes central nervous system
T15064 30382-30388 UBERON:0001045 denotes midgut
T15063 30370-30380 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T15062 30362-30369 UBERON:0001002 denotes cuticle
T15061 30350-30358 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T15060 30345-30349 PR_EXT:Pygo denotes Pygo
T15059 30310-30320 NCBITaxon:7215 denotes Drosophila
T15058 30239-30252 GO:0016055 denotes Wnt signaling
T15057 30175-30189 UBERON:0000939 denotes imaginal discs
T15056 30171-30174 UBERON:0000970 denotes eye
T15055 30161-30165 UBERON:0000023 denotes wing
T15054 30156-30159 UBERON:0005895 denotes leg
T15053 30110-30117 SO_EXT:sequence_altered_entity denotes mutants
T15052 30105-30109 PR_EXT:Pygo denotes Pygo
T15051 30088-30101 GO:0016055 denotes Wnt signaling
T15050 30025-30048 GO:0060070 denotes canonical Wnt signaling
T15049 29999-30003 SO_EXT:0000704 denotes gene
T15048 29991-29998 PR_EXT:Q9V9W8 denotes Pygopus
T15047 29975-29985 NCBITaxon:7215 denotes Drosophila
T15267 35773-35778 SO_EXT:0000704 denotes genes
T15266 35756-35765 SO_EXT:0000167 denotes promoters
T15265 35685-35693 SO_EXT:0000167 denotes promoter
T15264 35641-35651 GO:0010467 denotes expression
T15263 35628-35636 GO:0065007 denotes monitors
T15262 35609-35618 SO_EXT:0000902 denotes transgene
T15261 35605-35608 GO_EXT:0015925 denotes gal
T15260 35468-35491 GO:0060070 denotes canonical Wnt signaling
T15259 35454-35464 GO_EXT:regulator denotes modulators
T15258 35433-35438 SO_EXT:0000704 denotes genes
T15257 35425-35432 PR_EXT:Q9V9W8 denotes Pygopus
T15256 35415-35424 NCBITaxon:40674 denotes mammalian
T15255 35404-35411 SO_EXT:sequence_coding_function denotes encoded
T15254 35395-35403 CHEBI_PR_EXT:protein denotes proteins
T15253 35277-35290 GO:0048513 denotes organogenesis
T15252 35260-35267 SO_EXT:sequence_altered_entity denotes mutants
T15251 35254-35259 PR_EXT:000013524 denotes Pygo2
T15250 35248-35253 PR_EXT:000013523 denotes Pygo1
T15249 35178-35185 UBERON:0002113 denotes kidneys
T15248 35111-35117 UBERON:0000479 denotes tissue
T15247 35097-35104 UBERON:0000922 denotes embryos
T15246 35090-35096 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T15245 35084-35089 PR_EXT:000013524 denotes Pygo2
T11977 27266-27272 UBERON:0000479 denotes tissue
T11976 27202-27218 GO_EXT:0008236 denotes serine proteases
T11975 27202-27208 CHEBI_SO_EXT:serine denotes serine
T11974 27189-27196 PR_EXT:000027795 denotes trypsin
T11973 27144-27148 PR_EXT:000009416 denotes Klk6
T11972 27135-27139 PR_EXT:000009415 denotes Klk5
T11971 27114-27122 PR_EXT:000016340 denotes Timeless
T11970 27093-27097 PR_EXT:000014395 denotes Ren2
T11969 27076-27080 PR_EXT:000009416 denotes Klk6
T11968 27059-27063 PR_EXT:000009415 denotes Klk5
T11967 27043-27049 UBERON:0002113 denotes kidney
T11966 27038-27042 SO_EXT:sequence_nullness denotes null
T11965 27032-27037 PR_EXT:000013524 denotes Pygo2
T11964 27026-27031 PR_EXT:000013523 denotes Pygo1
T11963 27007-27018 GO_EXT:positive_regulation denotes upregulated
T11962 27001-27006 SO_EXT:0000704 denotes genes
T11961 24934-24944 GO_PATO_EXT:biological_maturation denotes maturation
T11953 24805-24814 GO:0010467 denotes expressed
T11952 24779-24786 PR_EXT:000015966 denotes Slco1a4
T11951 24766-24777 GO_EXT:biological_mover_or_transporter denotes transporter
T11950 24752-24765 CHEBI:25696 denotes organic anion
T11949 24734-24741 UBERON:0001285 denotes nephron
T11948 24712-24726 GO:0046323 denotes glucose uptake
T11947 24712-24719 CHEBI:17234 denotes glucose
T11946 24669-24674 UBERON:0002113 denotes renal
T11945 24649-24658 GO:0030849 denotes autosomal
T11944 24614-24621 UBERON:0001285 denotes nephron
T11943 24608-24613 UBERON:0007023 denotes adult
T11942 24584-24600 UBERON:0004134 denotes proximal tubules
T11941 24567-24576 GO:0010467 denotes expressed
T11940 24557-24563 PR_EXT:000015169 denotes Slc5a2
T11939 24535-24542 PR_EXT:000015966 denotes Slco1a4
T11938 24510-24516 PR_EXT:000015169 denotes Slc5a2
T11937 24489-24495 PR_EXT:000006067 denotes Cxcl13
T11936 24472-24479 UBERON:0002113 denotes kidneys
T11935 24465-24471 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11934 24429-24434 SO_EXT:0000704 denotes genes
T11933 24414-24421 UBERON:0002113 denotes kidneys
T11932 24407-24413 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11931 24344-24357 GO_EXT:negative_regulation denotes downregulated
T11930 24319-24324 PR_EXT:000013524 denotes Pygo2
T11929 24309-24314 PR_EXT:000013523 denotes Pygo1
T11928 24131-24136 SO_EXT:0000704 denotes genes
T11927 24095-24105 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T11926 24070-24077 UBERON:0002113 denotes kidneys
T11925 24068-24069 SO_EXT:sequence_nullness_or_absence denotes -
T11924 24066-24067 SO_EXT:sequence_nullness_or_absence denotes -
T11923 24061-24066 PR_EXT:000013524 denotes Pygo2
T11922 24059-24060 SO_EXT:sequence_nullness_or_absence denotes -
T11921 24057-24058 SO_EXT:sequence_nullness_or_absence denotes -
T11920 24052-24057 PR_EXT:000013523 denotes Pygo1
T11919 24038-24047 SO_EXT:wild_type_entity_or_quality denotes wild-type
T11918 23992-23997 SO_EXT:0000704 denotes genes
T11917 23966-23976 GO:0010467 denotes expression
T11916 23917-23930 GO:0016055 denotes Wnt signaling
T11915 23905-23913 SO_EXT:0000167 denotes promoter
T11914 23889-23897 GO_EXT:reaction_or_response denotes response
T11913 23876-23884 GO:0065007 denotes monitors
T11912 23857-23866 SO_EXT:0000902 denotes transgene
T11911 23853-23856 GO_EXT:0015925 denotes gal
T11910 23812-23827 GO:0010467 denotes gene expression
T11909 23812-23816 SO_EXT:0000704 denotes gene
T11908 23751-23758 UBERON:0002113 denotes kidneys
T11907 23744-23750 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T11906 23738-23743 PR_EXT:000013524 denotes Pygo2
T11905 23732-23737 PR_EXT:000013523 denotes Pygo1
T11904 23709-23724 GO:0010467 denotes gene expression
T11903 23709-23713 SO_EXT:0000704 denotes gene
T11902 23658-23665 UBERON:0002113 denotes kidneys
T11901 23653-23657 SO_EXT:sequence_nullness denotes null
T11900 23647-23652 PR_EXT:000013524 denotes Pygo2
T11899 23641-23646 PR_EXT:000013523 denotes Pygo1
T12032 28485-28490 PR_EXT:000013523 denotes Pygo1
T12031 28472-28477 SO_EXT:0000704 denotes genes
T12030 28451-28464 GO:0016055 denotes Wnt signaling
T12029 28420-28430 GO:0010467 denotes expression
T12028 28354-28361 UBERON:0002113 denotes kidneys
T12027 28349-28353 SO_EXT:sequence_nullness denotes null
T12026 28343-28348 PR_EXT:000013524 denotes Pygo2
T12025 28337-28342 PR_EXT:000013523 denotes Pygo1
T12024 28296-28306 GO:0010467 denotes expression
T12023 28252-28257 PR_EXT:000017426 denotes Wisp1
T12022 28232-28241 PR_EXT:000005121 denotes cyclin D1
T12021 28223-28231 SO_EXT:sequence_coding_function denotes encoding
T12020 28217-28222 PR_EXT:000005121 denotes Ccnd1
T12019 28203-28213 GO:0010467 denotes expression
T12018 28174-28181 UBERON:0002113 denotes kidneys
T12017 28167-28173 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T12016 28153-28162 SO_EXT:wild_type_entity_or_quality denotes wild-type
T12015 28134-28144 GO:0010467 denotes expression
T12014 28097-28102 SO_EXT:0000704 denotes genes
T12013 28047-28062 GO_EXT:negative_regulation denotes down regulation
T12012 27982-27987 CHEBI_SO_EXT:molecular_probe denotes probe
T12011 27976-27981 PR_EXT:000013524 denotes Pygo2
T12010 27966-27971 PR_EXT:000013523 denotes Pygo1
T12009 27904-27911 UBERON:0002113 denotes kidneys
T12008 27897-27903 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T12007 27895-27896 SO_EXT:sequence_nullness_or_absence denotes -
T12006 27893-27894 SO_EXT:sequence_nullness_or_absence denotes -
T12005 27888-27893 PR_EXT:000013524 denotes Pygo2
T12004 27886-27887 SO_EXT:sequence_nullness_or_absence denotes -
T12003 27884-27885 SO_EXT:sequence_nullness_or_absence denotes -
T12002 27879-27884 PR_EXT:000013523 denotes Pygo1
T12001 27829-27839 GO:0010467 denotes expression
T12000 27756-27779 GO:0001763 denotes branching morphogenesis
T11999 27747-27755 UBERON:0000056 denotes ureteric
T11998 27738-27746 GO:0065007 denotes regulate
T11997 27700-27713 UBERON:0006364 denotes ureteric tips
T11996 27673-27682 GO:0010467 denotes expressed
T11995 27636-27667 GO:0042752 denotes regulation of circadian rhythms
T11994 27599-27619 GO_EXT:transcription_factor denotes transcription factor
T11993 27599-27612 GO_EXT:transcription denotes transcription
T11992 27587-27595 PR_EXT:000016340 denotes Timeless
T11991 27558-27580 UBERON:0004100 denotes collecting-duct system
T11990 27547-27553 UBERON:0000056 denotes ureter
T11989 27466-27477 CHEBI_PR_EXT:angiotensin denotes angiotensin
T11988 27460-27465 PR_EXT:000013883 denotes renin
T11987 27421-27426 UBERON:0000178 denotes blood
T11986 27390-27401 CHEBI_PR_EXT:angiotensin denotes angiotensin
T11985 27384-27389 PR_EXT:000013883 denotes renin
T11984 27361-27368 PR_EXT:000014394 denotes Renin 1
T11983 27347-27360 GO_EXT:0004175 denotes endopeptidase
T11982 27332-27339 SO_EXT:0000853 denotes homolog
T11981 27324-27328 PR_EXT:000014395 denotes Ren2
T11980 27303-27308 UBERON:0000178 denotes blood
T11979 27289-27317 GO:0008217 denotes regulation of blood pressure
T11978 27266-27283 GO:0048771 denotes tissue remodeling
T9318 23609-23615 UBERON:0002113 denotes kidney
T9317 23568-23590 UBERON:0003220 denotes metanephric mesenchyme
T9316 23537-23560 GO:0060070 denotes canonical Wnt signaling
T9315 23496-23505 SO_EXT:0000902 denotes transgene
T9314 23446-23456 GO:0010467 denotes expression
T9313 23442-23445 GO_EXT:0015925 denotes gal
T9312 23391-23404 GO:0001822 denotes nephrogenesis
T9311 23356-23378 UBERON:0003220 denotes metanephric mesenchyme
T9310 23343-23347 CHEBI:48607 denotes LiCl
T9309 23306-23311 UBERON:0000062 denotes organ
T9308 23299-23305 UBERON:0002113 denotes kidney
T9307 23282-23295 GO:0001822 denotes nephrogenesis
T9306 23240-23244 PR_EXT:glycogen_synthase_kinase_3 denotes GSK3
T9305 23194-23217 GO:0060070 denotes canonical Wnt signaling
T9304 23171-23175 CHEBI:48607 denotes LiCl
T9303 23153-23169 CHEBI:48607 denotes lithium chloride
T9302 23127-23149 UBERON:0003220 denotes metanephric mesenchyme
T9301 23058-23080 UBERON:0003220 denotes metanephric mesenchyme
T9300 23027-23050 GO:0060070 denotes canonical Wnt signaling
T9299 22989-22998 SO_EXT:0000902 denotes transgene
T9297 22930-22952 UBERON:0003220 denotes metanephric mesenchyme
T9296 22909-22922 GO:0001822 denotes nephrogenesis
T9295 22890-22897 SO_EXT:sequence_altered_entity denotes mutants
T9294 22884-22889 PR_EXT:000017453 denotes Wnt9b
T9293 22877-22883 SO_EXT:sequence_rescue_process denotes rescue
T9292 22848-22871 GO:0060070 denotes canonical Wnt signaling
T9252 21311-21316 PR_EXT:000013524 denotes Pygo2
T9251 21309-21310 SO_EXT:sequence_nullness_or_absence denotes -
T9250 21307-21308 SO_EXT:sequence_nullness_or_absence denotes -
T9249 21302-21307 PR_EXT:000013523 denotes Pygo1
T9248 21264-21274 GO:0010467 denotes expression
T9247 21260-21263 GO_EXT:0015925 denotes gal
T9246 21222-21245 GO:0060070 denotes canonical Wnt signaling
T9245 21213-21218 PR_EXT:000013523 denotes Pygo1
T9244 21166-21176 GO:0010467 denotes expression
T9243 21162-21165 GO_EXT:0015925 denotes gal
T9242 21148-21157 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9241 21127-21128 SO_EXT:sequence_nullness_or_absence denotes -
T9240 21125-21126 SO_EXT:normal_or_wild_type_or_present denotes +
T9239 21120-21125 PR_EXT:000013524 denotes Pygo2
T9238 21118-21119 SO_EXT:sequence_nullness_or_absence denotes -
T9237 21116-21117 SO_EXT:sequence_nullness_or_absence denotes -
T9236 21111-21116 PR_EXT:000013523 denotes Pygo1
T9235 21040-21041 SO_EXT:normal_or_wild_type_or_present denotes +
T9234 21038-21039 SO_EXT:normal_or_wild_type_or_present denotes +
T9233 21033-21038 PR_EXT:000013524 denotes Pygo2
T9232 21031-21032 SO_EXT:sequence_nullness_or_absence denotes -
T9231 21029-21030 SO_EXT:sequence_nullness_or_absence denotes -
T9230 21024-21029 PR_EXT:000013523 denotes Pygo1
T9229 21011-21016 PR_EXT:000013523 denotes Pygo1
T9228 20991-21001 GO:0010467 denotes expression
T9227 20987-20990 GO_EXT:0015925 denotes gal
T9226 20945-20946 SO_EXT:sequence_nullness_or_absence denotes -
T9225 20943-20944 SO_EXT:sequence_nullness_or_absence denotes -
T9224 20938-20943 PR_EXT:000013524 denotes Pygo2
T9223 20936-20937 SO_EXT:sequence_nullness_or_absence denotes -
T9222 20934-20935 SO_EXT:sequence_nullness_or_absence denotes -
T9221 20929-20934 PR_EXT:000013523 denotes Pygo1
T9220 20923-20924 SO_EXT:sequence_nullness_or_absence denotes -
T9219 20921-20922 SO_EXT:sequence_nullness_or_absence denotes -
T9218 20916-20921 PR_EXT:000013524 denotes Pygo2
T9217 20914-20915 SO_EXT:sequence_nullness_or_absence denotes -
T9216 20912-20913 SO_EXT:normal_or_wild_type_or_present denotes +
T9214 20901-20905 SO_EXT:0000704 denotes gene
T9213 20895-20900 PR_EXT:000013524 denotes Pygo2
T9212 20863-20870 UBERON:0002113 denotes kidneys
T9211 20831-20846 GO_EXT:0004565 denotes β-galactosidase
T9210 20812-20821 SO_EXT:0000902 denotes transgene
T9209 20770-20775 SO_EXT:null_sequence_entity denotes nulls
T9208 20764-20769 PR_EXT:000013524 denotes Pygo2
T9207 20758-20763 PR_EXT:000013523 denotes Pygo1
T9206 20749-20753 SO_EXT:null_sequence_entity denotes null
T9205 20743-20748 PR_EXT:000013524 denotes Pygo2
T9204 20717-20727 GO:0010467 denotes expression
T9203 20704-20707 GO_EXT:0015925 denotes gal
T9202 20627-20635 UBERON:0000056 denotes ureteric
T9201 20596-20619 GO:0060070 denotes canonical Wnt signaling
T9200 20588-20592 SO_EXT:0000704 denotes gene
T9199 20582-20587 PR_EXT:000013524 denotes Pygo2
T9198 20537-20544 UBERON:0002113 denotes kidneys
T9197 20510-20511 SO_EXT:sequence_nullness_or_absence denotes -
T9196 20508-20509 SO_EXT:sequence_nullness_or_absence denotes -
T9195 20503-20508 PR_EXT:000013524 denotes Pygo2
T9194 20501-20502 SO_EXT:sequence_nullness_or_absence denotes -
T9193 20499-20500 SO_EXT:sequence_nullness_or_absence denotes -
T9192 20494-20499 PR_EXT:000013523 denotes Pygo1
T9191 20467-20468 SO_EXT:sequence_nullness_or_absence denotes -
T9190 20465-20466 SO_EXT:normal_or_wild_type_or_present denotes +
T9189 20460-20465 PR_EXT:000013524 denotes Pygo2
T9188 20458-20459 SO_EXT:sequence_nullness_or_absence denotes -
T9187 20456-20457 SO_EXT:sequence_nullness_or_absence denotes -
T9186 20451-20456 PR_EXT:000013523 denotes Pygo1
T9185 20430-20431 SO_EXT:sequence_nullness_or_absence denotes -
T9184 20428-20429 SO_EXT:normal_or_wild_type_or_present denotes +
T9183 20423-20428 PR_EXT:000013524 denotes Pygo2
T9182 20421-20422 SO_EXT:normal_or_wild_type_or_present denotes +
T9181 20419-20420 SO_EXT:normal_or_wild_type_or_present denotes +
T9180 20414-20419 PR_EXT:000013523 denotes Pygo1
T9179 20328-20332 SO_EXT:sequence_nullness denotes null
T9178 20322-20327 PR_EXT:000013524 denotes Pygo2
T9177 20302-20314 UBERON:0001224 denotes renal pelvis
T9176 20333-20339 UBERON:0001232 denotes kidney
T9175 20315-20317 _FRAGMENT denotes of
T9174 20281-20297 _FRAGMENT denotes collecting ducts
T9173 20268-20273 CL_GO_EXT:cell denotes cells
T9171 20183-20184 SO_EXT:sequence_nullness_or_absence denotes -
T9170 20181-20182 SO_EXT:sequence_nullness_or_absence denotes -
T9169 20176-20181 PR_EXT:000013524 denotes Pygo2
T9168 20174-20175 SO_EXT:sequence_nullness_or_absence denotes -
T9167 20172-20173 SO_EXT:normal_or_wild_type_or_present denotes +
T9166 20167-20172 PR_EXT:000013523 denotes Pygo1
T9165 20185-20191 UBERON:0001225 denotes kidney
T9164 20155-20164 _FRAGMENT denotes cortex of
T9163 20096-20102 UBERON:0002113 denotes kidney
T9162 20094-20095 SO_EXT:sequence_nullness_or_absence denotes -
T9161 20092-20093 SO_EXT:normal_or_wild_type_or_present denotes +
T9160 20087-20092 PR_EXT:000013524 denotes Pygo2
T9159 20085-20086 SO_EXT:sequence_nullness_or_absence denotes -
T9158 20083-20084 SO_EXT:normal_or_wild_type_or_present denotes +
T9157 20078-20083 PR_EXT:000013523 denotes Pygo1
T9156 20055-20063 UBERON:0000056 denotes ureteric
T9155 20024-20029 CHEBI:75055 denotes X-gal
T9154 20015-20023 UBERON:0001851 denotes Cortical
T9153 19993-19999 UBERON:0002113 denotes kidney
T9152 19962-19974 UBERON:0001224 denotes renal pelvis
T9151 19940-19948 UBERON:0000056 denotes ureteric
T9150 19931-19939 UBERON:0001851 denotes cortical
T9149 19900-19923 GO:0060070 denotes canonical Wnt signaling
T9148 19811-19818 SO_EXT:sequence_altered_entity denotes mutants
T9147 19806-19810 PR_EXT:Pygo denotes Pygo
T9146 19777-19780 GO_EXT:0015925 denotes gal
T9145 19743-19753 GO:0010467 denotes expression
T9144 19739-19742 GO_EXT:0015925 denotes gal
T9143 19706-19710 NCBITaxon:10088 denotes mice
T9142 19704-19705 SO_EXT:sequence_nullness_or_absence denotes -
T9141 19702-19703 SO_EXT:normal_or_wild_type_or_present denotes +
T9140 19697-19702 PR_EXT:000013524 denotes Pygo2
T9139 19695-19696 SO_EXT:sequence_nullness_or_absence denotes -
T9138 19693-19694 SO_EXT:normal_or_wild_type_or_present denotes +
T9137 19688-19693 PR_EXT:000013523 denotes Pygo1
T9136 19682-19683 SO_EXT:sequence_nullness_or_absence denotes -
T9135 19680-19681 SO_EXT:normal_or_wild_type_or_present denotes +
T9134 19675-19680 PR_EXT:000013524 denotes Pygo2
T9133 19673-19674 SO_EXT:sequence_nullness_or_absence denotes -
T9132 19671-19672 SO_EXT:sequence_nullness_or_absence denotes -
T9131 19666-19671 PR_EXT:000013523 denotes Pygo1
T9130 19623-19644 UBERON:0003890 denotes paramesonephric ducts
T9129 19601-19606 CHEBI:75055 denotes X-gal
T9128 19578-19585 SO_EXT:sequence_altered_entity denotes mutants
T9127 19527-19537 GO:0010467 denotes expression
T9126 19480-19484 NCBITaxon:10088 denotes mice
T9125 19478-19479 SO_EXT:sequence_nullness_or_absence denotes -
T9124 19476-19477 SO_EXT:sequence_nullness_or_absence denotes -
T9123 19471-19476 PR_EXT:000013524 denotes Pygo2
T9122 19461-19466 UBERON:0003890 denotes ducts
T9121 19433-19448 _FRAGMENT denotes paramesonephric
T9120 19415-19425 GO:0010467 denotes expression
T9119 19402-19405 GO_EXT:0015925 denotes gal
T9118 19369-19374 SO_EXT:0000704 denotes genes
T9117 19363-19368 PR_EXT:000013524 denotes Pygo2
T9116 19353-19358 PR_EXT:000013523 denotes Pygo1
T9115 19321-19326 PR_EXT:000013524 denotes Pygo2
T9114 19297-19307 GO:0010467 denotes expression
T9113 19293-19296 GO_EXT:0015925 denotes gal
T9112 19249-19254 SO_EXT:0000704 denotes genes
T9111 19243-19248 PR_EXT:000013524 denotes Pygo2
T9110 19233-19238 PR_EXT:000013523 denotes Pygo1
T9109 19212-19220 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9108 19175-19185 GO:0010467 denotes expression
T9107 19123-19127 SO_EXT:0000704 denotes gene
T9106 19117-19122 PR_EXT:000013523 denotes Pygo1
T9105 19069-19092 GO:0060070 denotes canonical Wnt signaling
T9104 19012-19022 GO:0010467 denotes expression
T9103 18978-18985 UBERON:0002113 denotes kidneys
T9102 18970-18971 SO_EXT:sequence_nullness_or_absence denotes -
T9101 18968-18969 SO_EXT:sequence_nullness_or_absence denotes -
T9100 18963-18968 PR_EXT:000013524 denotes Pygo2
T9099 18961-18962 SO_EXT:sequence_nullness_or_absence denotes -
T9098 18959-18960 SO_EXT:normal_or_wild_type_or_present denotes +
T9097 18954-18959 PR_EXT:000013523 denotes Pygo1
T9096 18914-18922 UBERON:0000056 denotes ureteric
T9095 18892-18897 CHEBI:75055 denotes X-gal
T9094 18873-18877 SO_EXT:0000704 denotes gene
T9093 18867-18872 PR_EXT:000013524 denotes Pygo2
T9092 18857-18866 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9091 18832-18838 UBERON:0002113 denotes kidney
T9090 18821-18831 SO_EXT:transgenic_entity denotes transgenic
T9089 18817-18820 GO_EXT:0015925 denotes gal
T9088 18775-18780 CHEBI:75055 denotes X-gal
T9087 18738-18747 SO_EXT:0000902 denotes transgene
T5652 12585-12592 UBERON:0000922 denotes embryos
T5651 12583-12584 SO_EXT:normal_or_wild_type_or_present denotes +
T5639 12313-12319 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5638 12289-12294 PR_EXT:000013524 denotes Pygo2
T5637 12283-12288 PR_EXT:000013523 denotes Pygo1
T5636 12247-12253 SO_EXT:0001023 denotes allele
T5635 12241-12246 PR_EXT:000013524 denotes Pygo2
T5634 12231-12240 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5633 12143-12150 UBERON:0002113 denotes kidneys
T5632 12138-12142 SO_EXT:sequence_nullness denotes null
T5631 12132-12137 PR_EXT:000013524 denotes Pygo2
T5630 12126-12131 PR_EXT:000013523 denotes Pygo1
T5629 12100-12117 UBERON:0006364 denotes ureteric bud tips
T5628 12081-12082 UBERON:0002113 denotes s
T5627 12080-12081 SO_EXT:sequence_nullness denotes l
T5626 11590-11605 UBERON:0004199 denotes S-shaped bodies
T5610 11098-11101 UBERON:0000483 denotes ite
T5609 11097-11098 PR_EXT:000001447 denotes C
T5608 11093-11095 UBERON:0003220 denotes an
T5607 11089-11092 PR_EXT:000017459 denotes Wt1
T5606 10237-10249 UBERON:0000084 denotes ureteric bud
T5605 10171-10188 NCBITaxon:271171 denotes Dolichos biflorus
T5604 10158-10164 UBERON:0002113 denotes kidney
T5603 10131-10139 UBERON:0001285 denotes nephrons
T5602 10106-10118 UBERON:0000084 denotes ureteric bud
T5601 10059-10069 UBERON:0000483 denotes epithelial
T5600 10018-10028 PR_EXT:000001447 denotes E-cadherin
T5650 12581-12582 SO_EXT:normal_or_wild_type_or_present denotes +
T5649 12576-12581 PR_EXT:000013524 denotes Pygo2
T5648 12570-12571 SO_EXT:sequence_nullness_or_absence denotes -
T5647 12568-12569 SO_EXT:normal_or_wild_type_or_present denotes +
T5646 12563-12568 PR_EXT:000013524 denotes Pygo2
T5645 12521-12537 UBERON:0006364 denotes ureteric bud-tip
T5644 12475-12480 PR_EXT:000013524 denotes Pygo2
T5643 12467-12471 SO_EXT:sequence_copy_entity denotes copy
T5642 12457-12466 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5641 12386-12403 UBERON:0006364 denotes ureteric bud tips
T5640 12320-12327 UBERON:0002113 denotes kidneys
T4602 8485-8490 PR_EXT:000013523 denotes Pygo1
T4601 8458-8468 GO:0010467 denotes expression
T4600 8322-8327 PR_EXT:000013523 denotes Pygo1
T4599 8308-8318 GO:0010467 denotes expression
T4598 8253-8266 GO:0097617 denotes hybridization
T4597 8238-8244 UBERON:0002113 denotes kidney
T4596 8214-8219 PR_EXT:000013524 denotes Pygo2
T4595 8204-8209 PR_EXT:000013523 denotes Pygo1
T4594 8190-8200 GO:0010467 denotes Expression
T837 25-38 GO:0016055 denotes Wnt signaling
T838 42-51 NCBITaxon:40674 denotes mammalian
T839 52-58 UBERON:0002113 denotes kidney
T840 52-70 GO:0001822 denotes kidney development
T841 96-103 PR_EXT:Q9V9W8 denotes pygopus
T842 104-108 SO_EXT:0000704 denotes gene
T843 112-122 NCBITaxon:7215 denotes Drosophila
T844 123-130 SO_EXT:sequence_coding_function denotes encodes
T845 161-170 PR_EXT:P18824 denotes Armadillo
T846 172-181 PR_EXT:000002198 denotes β-catenin
T847 183-196 GO_EXT:transcription denotes transcription
T848 183-203 GO_EXT:transcription_factor denotes transcription factor
T849 183-211 GO:0005667 denotes transcription factor complex
T850 215-238 GO:0060070 denotes canonical Wnt signaling
T851 278-285 PR_EXT:Q9V9W8 denotes Pygopus
T852 295-318 GO:0060070 denotes canonical Wnt signaling
T853 322-328 UBERON:0002113 denotes kidney
T854 322-340 GO:0001822 denotes kidney development
T855 351-360 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T856 382-391 NCBITaxon:40674 denotes mammalian
T857 392-401 SO_EXT:0000855 denotes orthologs
T858 403-408 PR_EXT:000013523 denotes Pygo1
T859 413-418 PR_EXT:000013524 denotes Pygo2
T860 434-442 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T861 443-450 SO_EXT:sequence_deletion_process denotes deleted
T862 463-478 SO_EXT:coding_sequence denotes coding sequence
T863 507-513 SO_EXT:0000417 denotes domain
T864 548-552 SO_EXT:sequence_nullness denotes null
T865 563-568 PR_EXT:000013524 denotes Pygo2
T866 580-587 SO_EXT:sequence_altered_entity denotes mutants
T868 629-634 GO:0007567 denotes birth
T869 663-667 UBERON_EXT:lens denotes lens
T870 678-684 GO_EXT:biological_growth_entity_or_process denotes growth
T871 706-712 UBERON:0002113 denotes kidney
T872 706-724 GO:0001822 denotes kidney development
T873 774-779 PR_EXT:000013523 denotes Pygo1
T874 791-798 SO_EXT:sequence_altered_entity denotes mutants
T875 883-888 PR_EXT:000013523 denotes Pygo1
T876 889-894 PR_EXT:000013524 denotes Pygo2
T877 906-913 SO_EXT:sequence_altered_entity denotes mutants
T878 972-975 GO_EXT:0015925 denotes gal
T879 976-985 SO_EXT:0000902 denotes transgene
T880 998-1021 GO:0060070 denotes canonical Wnt signaling
T881 1047-1057 GO:0010467 denotes expression
T882 1061-1066 PR_EXT:000013523 denotes Pygo1
T883 1066-1067 SO_EXT:sequence_nullness_or_absence denotes -
T884 1068-1069 SO_EXT:sequence_nullness_or_absence denotes -
T885 1070-1075 PR_EXT:000013524 denotes Pygo2
T886 1075-1076 SO_EXT:sequence_nullness_or_absence denotes -
T887 1077-1078 SO_EXT:sequence_nullness_or_absence denotes -
T888 1079-1086 SO_EXT:sequence_altered_entity denotes mutants
T889 1093-1099 UBERON:0000479 denotes tissue
T890 1148-1153 PR_EXT:000013523 denotes Pygo1
T891 1158-1163 PR_EXT:000013524 denotes Pygo2
T892 1164-1169 SO_EXT:0000704 denotes genes
T893 1193-1203 GO:0010467 denotes expression
T894 1222-1228 UBERON:0002113 denotes kidney
T895 1256-1263 UBERON:0003891 denotes stromal
T896 1256-1268 CL:0000499 denotes stromal cell
T897 1264-1268 CL_GO_EXT:cell denotes cell
T898 1314-1320 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T899 1321-1328 UBERON:0002113 denotes kidneys
T900 1360-1372 UBERON:0000084 denotes ureteric bud
T901 1377-1399 UBERON:0003220 denotes metanephric mesenchyme
T902 1422-1448 _FRAGMENT denotes Branching morphogenesis of
T903 1453-1465 GO:0001658 denotes ureteric bud
T904 1453-1465 UBERON:0000084 denotes ureteric bud
T905 1572-1578 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T906 1579-1585 UBERON:0002113 denotes kidney
T907 1648-1658 UBERON:0003104 denotes mesenchyme
T908 1671-1683 UBERON:0000084 denotes ureteric bud
T909 1685-1692 UBERON:0001285 denotes Nephron
T910 1685-1702 GO:0072006 denotes Nephron formation
T911 1768-1778 GO:0010467 denotes expression
T912 1790-1795 SO_EXT:0000704 denotes genes
T913 1807-1813 PR_EXT:000006067 denotes Cxcl13
T914 1815-1821 PR_EXT:000015169 denotes Slc5a2
T915 1823-1827 PR_EXT:000009415 denotes Klk5
T916 1829-1833 PR_EXT:000014395 denotes Ren2
T917 1838-1846 PR_EXT:000016340 denotes Timeless
T918 1889-1895 UBERON:0002113 denotes kidney
T919 1889-1907 GO:0001822 denotes kidney development
T920 1925-1934 NCBITaxon:40674 denotes mammalian
T921 1935-1942 PR_EXT:Q9V9W8 denotes Pygopus
T922 1943-1948 SO_EXT:0000704 denotes genes
T923 1973-1999 _FRAGMENT denotes branching morphogenesis of
T924 2004-2016 GO:0001658 denotes ureteric bud
T925 2004-2016 UBERON:0000084 denotes ureteric bud
T926 2024-2030 UBERON:0002113 denotes kidney
T927 2024-2042 GO:0001822 denotes kidney development
T928 2104-2110 UBERON:0002113 denotes kidney
T929 2129-2142 UBERON:0000467 denotes organ systems
T930 2192-2199 PR_EXT:Q9V9W8 denotes Pygopus
T931 2217-2224 NCBITaxon:40674 denotes mammals
T932 2229-2239 NCBITaxon:7215 denotes Drosophila
T933 2244-2251 NCBITaxon:40674 denotes mammals
T934 2257-2262 PR_EXT:000013523 denotes Pygo1
T935 2263-2268 PR_EXT:000013524 denotes Pygo2
T936 2269-2274 SO_EXT:0000704 denotes genes
T937 2307-2330 GO:0060070 denotes canonical Wnt signaling
T938 2350-2357 UBERON:0000467 denotes systems
T939 2395-2406 _FRAGMENT denotes transducers
T940 2423-2425 _FRAGMENT denotes of
T941 2430-2446 GO_EXT:0004871 denotes signal intensity
T942 2411-2421 GO_EXT:regulator denotes modulators
T2522 2460-2473 GO:0016055 denotes Wnt signaling
T2523 2521-2527 UBERON:0002113 denotes kidney
T2524 2521-2539 GO:0001822 denotes kidney development
T2525 2583-2595 UBERON:0000084 denotes ureteric bud
T2526 2600-2622 UBERON:0003220 denotes metanephric mesenchyme
T2527 2629-2642 GO:0001822 denotes nephrogenesis
T2528 2652-2664 UBERON:0000084 denotes ureteric bud
T2529 2677-2682 PR_EXT:000017453 denotes Wnt9b
T2530 2724-2734 UBERON:0003104 denotes mesenchyme
T2531 2743-2751 UBERON:0001285 denotes nephrons
T2532 2757-2761 PR_EXT:000017444 denotes Wnt4
T2533 2785-2807 UBERON:0003220 denotes metanephric mesenchyme
T2534 2833-2846 GO:0001822 denotes nephrogenesis
T2535 2865-2870 PR_EXT:000017438 denotes Wnt11
T2536 2872-2880 GO:0046903 denotes secreted
T2537 2888-2905 UBERON:0006364 denotes ureteric bud tips
T2538 2958-2968 CL:0000125 denotes glial cell
T2539 2958-3001 PR_EXT:000007928 denotes glial cell line-derived neurotrophic factor
T2540 2964-2968 CL_GO_EXT:cell denotes cell
T2541 2982-2994 GO_EXT:neuron_development_or_generation denotes neurotrophic
T2542 3003-3007 PR_EXT:000007928 denotes GDNF
T2543 3009-3019 GO:0010467 denotes expression
T2544 3027-3049 UBERON:0003220 denotes metanephric mesenchyme
T2545 3055-3064 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T2546 3068-3073 PR_EXT:000017453 denotes Wnt9b
T2547 3077-3081 PR_EXT:000017444 denotes Wnt4
T2548 3112-3119 UBERON:0001285 denotes nephron
T2549 3112-3129 GO:0072006 denotes nephron formation
T2550 3137-3142 PR_EXT:000017438 denotes Wnt11
T2551 3143-3150 SO_EXT:sequence_altered_entity denotes mutants
T2552 3183-3190 UBERON:0001285 denotes nephron
T2553 3230-3234 PR_EXT:000017444 denotes Wnt4
T2554 3239-3244 PR_EXT:000017438 denotes Wnt11
T2555 3264-3270 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signal
T2556 3373-3378 PR_EXT:000017453 denotes Wnt9b
T2557 3389-3412 GO:0060070 denotes canonical Wnt signaling
T2558 3420-3426 UBERON:0002113 denotes kidney
T2559 3432-3439 SO_EXT:0000704 denotes Genetic
T2560 3451-3461 NCBITaxon:7215 denotes Drosophila
T2561 3482-3489 PR_EXT:Q9V9W8 denotes Pygopus
T2562 3491-3495 PR_EXT:Pygo denotes Pygo
T2563 3497-3501 SO_EXT:0000704 denotes gene
T2564 3529-3552 GO:0060070 denotes canonical Wnt signaling
T2565 3561-3565 PR_EXT:Pygo denotes Pygo
T2566 3570-3573 PR_EXT:Q961D9 denotes Lgs
T2567 3588-3597 PR_EXT:000002198 denotes β-catenin
T2568 3609-3621 _FRAGMENT denotes formation of
T2569 3652-3659 GO:0065003 denotes complex
T2570 3636-3651 GO_EXT:transcription denotes transcriptional
T2571 3652-3659 GO:0032991 denotes complex
T2572 3697-3706 PR_EXT:000002198 denotes β-catenin
T2573 3714-3721 GO:0005634 denotes nucleus
T2574 3728-3731 PR_EXT:Q961D9 denotes Lgs
T2575 3732-3737 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T2576 3750-3759 PR_EXT:P18824 denotes armadillo
T2577 3760-3767 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T2578 3771-3780 PR_EXT:000002198 denotes β-catenin
T2579 3788-3792 PR_EXT:Pygo denotes Pygo
T2580 3808-3811 PR_EXT:Q961D9 denotes Lgs
T2581 3861-3871 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminal
T2582 3872-3878 SO_EXT:0000417 denotes domain
T2583 3882-3886 PR_EXT:Pygo denotes Pygo
T2584 3907-3922 GO_EXT:transcription denotes transcriptional
T2585 3949-3954 SO_EXT:sequence_or_structure_motif denotes motif
T2586 3990-3994 PR_EXT:Pygo denotes Pygo
T2587 4000-4003 PR_EXT:Q961D9 denotes Lgs
T2588 4037-4044 GO:0005634 denotes nuclear
T2589 4037-4064 SO_EXT:0001528 denotes nuclear localization signal
T2590 4045-4057 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T2591 4066-4069 SO_EXT:0001528 denotes NLS
T2592 4097-4107 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminal
T2593 4108-4114 SO_EXT:0000417 denotes domain
T2594 4118-4122 PR_EXT:Pygo denotes Pygo
T2595 4154-4161 GO:0005634 denotes nuclear
T2596 4154-4173 GO:0051170 denotes nuclear importation
T2597 4177-4186 PR_EXT:000002198 denotes β-catenin
T2598 4231-4238 PR_EXT:Q9V9W8 denotes pygopus
T2599 4239-4245 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2600 4275-4279 SO_EXT:0000704 denotes gene
T2601 4315-4338 GO:0060070 denotes canonical Wnt signaling
T2602 4346-4356 NCBITaxon:7215 denotes Drosophila
T2603 4378-4387 NCBITaxon:40674 denotes mammalian
T2604 4388-4394 SO_EXT:0001026 denotes genome
T2605 4422-4431 SO_EXT:0000855 denotes orthologs
T2606 4435-4445 NCBITaxon:7215 denotes Drosophila
T2607 4446-4450 PR_EXT:Pygo denotes Pygo
T2608 4452-4457 PR_EXT:000013523 denotes Pygo1
T2609 4462-4467 PR_EXT:000013524 denotes Pygo2
T2610 4516-4525 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2611 4529-4534 PR_EXT:000013523 denotes Pygo1
T2612 4539-4544 PR_EXT:000013524 denotes Pygo2
T2613 4632-4637 SO_EXT:0000704 denotes genes
T2614 4641-4664 GO:0060070 denotes canonical Wnt signaling
T2615 4672-4678 UBERON:0002113 denotes kidney
T2616 4672-4690 GO:0001822 denotes kidney development
T2617 4724-4730 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2618 4731-4738 UBERON:0000922 denotes embryos
T2619 4779-4802 GO:0060070 denotes canonical Wnt signaling
T2620 4831-4840 SO_EXT:0000902 denotes transgene
T2621 4841-4851 GO:0010467 denotes expression
T2622 4922-4927 GO:0007567 denotes birth
T2623 4961-4974 UBERON:0000467 denotes organ systems
T2624 5015-5021 UBERON:0002113 denotes kidney
T2625 5044-5070 _FRAGMENT denotes branching morphogenesis of
T2626 5075-5087 GO:0001658 denotes ureteric bud
T2627 5075-5087 UBERON:0000084 denotes ureteric bud
T2628 5128-5138 UBERON:0003104 denotes mesenchyme
T2629 5155-5167 UBERON:0000084 denotes ureteric bud
T2630 5191-5198 UBERON:0001285 denotes nephron
T2631 5191-5208 GO:0072006 denotes nephron formation
T2632 5263-5276 GO:0097617 denotes hybridization
T2633 5336-5343 NCBITaxon:40674 denotes mammals
T2634 5352-5362 NCBITaxon:7215 denotes Drosophila
T2635 5364-5371 PR_EXT:Q9V9W8 denotes Pygopus
T2636 5381-5404 GO:0060070 denotes canonical Wnt signaling
T2637 5452-5465 UBERON:0000467 denotes organ systems
T3464 5477-5482 PR_EXT:000013523 denotes Pygo1
T3465 5487-5492 PR_EXT:000013524 denotes Pygo2
T3466 5502-5511 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3467 5533-5538 PR_EXT:000013523 denotes Pygo1
T3468 5543-5548 PR_EXT:000013524 denotes Pygo2
T3469 5549-5554 SO_EXT:0000704 denotes genes
T3470 5558-5567 SO_EXT:sequence_insertion_process denotes inserting
T3471 5568-5582 SO_EXT:0000346 denotes LoxP sequences
T3472 5586-5591 SO:0000357 denotes flank
T3473 5601-5615 SO_EXT:coding_sequence denotes coding regions
T3474 5634-5641 SO_EXT:0000417 denotes domains
T3475 5666-5670 NCBITaxon:10088 denotes mice
T3476 5676-5681 GO:0007618 denotes mated
T3477 5687-5697 SO_EXT:transgenic_entity denotes transgenic
T3478 5698-5701 NCBITaxon:10358 denotes CMV
T3479 5706-5710 NCBITaxon:10088 denotes mice
T3480 5734-5738 SO_EXT:0000346 denotes LoxP
T3481 5739-5752 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T3482 5771-5775 SO_EXT:sequence_nullness denotes null
T3483 5776-5782 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3484 5783-5790 SO_EXT:0001023 denotes alleles
T3485 5840-5848 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T3486 5868-5884 SO_EXT:coding_sequence denotes coding sequences
T3487 5894-5899 SO_EXT:0000704 denotes genes
T3488 5918-5933 SO_EXT:coding_sequence denotes coding sequence
T3489 5938-5943 PR_EXT:000013523 denotes Pygo1
T3490 5955-5970 SO_EXT:coding_sequence denotes coding sequence
T3491 5975-5980 PR_EXT:000013524 denotes Pygo2
T3492 6002-6012 NCBITaxon:7215 denotes Drosophila
T3493 6043-6051 SO_EXT:missense_quality_or_entity denotes missense
T3494 6052-6060 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3495 6072-6078 SO_EXT:0000417 denotes domain
T3496 6093-6097 PR_EXT:Pygo denotes Pygo
T3497 6110-6123 GO:0016055 denotes Wnt signaling
T4050 6130-6135 PR_EXT:000013523 denotes Pygo1
T4051 6140-6145 PR_EXT:000013524 denotes Pygo2
T4052 6146-6152 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4053 6164-6169 PR_EXT:000013523 denotes Pygo1
T4054 6181-6185 SO_EXT:sequence_nullness denotes null
T4055 6186-6190 NCBITaxon:10088 denotes mice
T4056 6305-6312 PR_EXT:Q9V9W8 denotes pygopus
T4057 6313-6317 SO_EXT:0000704 denotes gene
T4058 6321-6334 GO:0016055 denotes Wnt signaling
T4059 6338-6348 NCBITaxon:7215 denotes Drosophila
T4060 6367-6377 GO:0010467 denotes expression
T4061 6404-6409 NCBITaxon:10088 denotes mouse
T4062 6410-6415 PR_EXT:000013523 denotes Pygo1
T4063 6416-6420 SO_EXT:0000704 denotes gene
T4064 6442-6447 UBERON:0000955 denotes brain
T4065 6449-6454 UBERON:0002101 denotes limbs
T4066 6456-6462 UBERON:0002113 denotes kidney
T4067 6467-6483 UBERON:0002539 denotes branchial arches
T4068 6555-6560 PR_EXT:000013524 denotes Pygo2
T4069 6572-6576 SO_EXT:sequence_nullness denotes null
T4070 6577-6581 NCBITaxon:10088 denotes mice
T4071 6594-6599 GO:0007567 denotes birth
T4072 6627-6631 GO:0016265 denotes died
T4073 6656-6659 UBERON:0001555 denotes gut
T4074 6661-6666 UBERON:0000948 denotes heart
T4075 6671-6676 UBERON:0002101 denotes limbs
T4076 6766-6779 GO:0016055 denotes Wnt signaling
T4077 6785-6790 PR_EXT:000013524 denotes Pygo2
T4078 6791-6798 SO_EXT:sequence_altered_entity denotes mutants
T4079 6818-6824 GO_EXT:biological_growth_entity_or_process denotes growth
T4080 6838-6842 UBERON_EXT:lens denotes lens
T4081 6858-6864 UBERON:0002113 denotes kidney
T4082 6973-6979 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4083 6980-6985 PR_EXT:000013523 denotes Pygo1
T4084 6990-6995 PR_EXT:000013524 denotes Pygo2
T4085 6996-7000 NCBITaxon:10088 denotes mice
T4086 7043-7048 PR_EXT:000013524 denotes Pygo2
T4087 7049-7054 SO_EXT:null_sequence_entity denotes nulls
T4088 7156-7163 SO_EXT:sequence_altered_entity denotes mutants
T4089 7201-7206 PR_EXT:000013524 denotes Pygo2
T4090 7289-7294 PR_EXT:000013523 denotes Pygo1
T4628 8880-8888 CHEBI_PR_EXT:protein denotes proteins
T4627 8864-8870 UBERON:0002113 denotes kidney
T4626 8864-8870 CL:1000497 denotes kidney
T4625 8840-8848 _FRAGMENT denotes cells of
T4624 8840-8845 CL_GO_EXT:cell denotes cells
T4623 8791-8798 GO:0005634 denotes nuclear
T4622 8768-8773 CL_GO_EXT:cell denotes cells
T4621 8760-8773 CL:0000499 denotes stromal cells
T4620 8760-8767 UBERON:0003891 denotes stromal
T4619 8741-8746 PR_EXT:000013524 denotes Pygo2
T4618 8708-8713 PR_EXT:000013523 denotes Pygo1
T4617 8694-8704 GO:0010467 denotes expression
T4616 8669-8674 CL_GO_EXT:cell denotes cells
T4615 8661-8674 CL:0000499 denotes stromal cells
T4614 8661-8668 UBERON:0003891 denotes stromal
T4613 8637-8655 UBERON:0005107 denotes capping mesenchyme
T4612 8623-8635 UBERON:0000084 denotes ureteric bud
T4611 8607-8615 CHEBI_PR_EXT:protein denotes proteins
T4610 8599-8606 SO_EXT:sequence_coding_function denotes encoded
T4609 8583-8595 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T4608 8575-8582 GO:0005634 denotes nuclear
T4607 8556-8565 GO:0010467 denotes expressed
T4606 8538-8543 SO_EXT:0000704 denotes genes
T4605 8525-8531 UBERON:0002113 denotes kidney
T4604 8501-8506 SO_EXT:0000704 denotes genes
T4603 8495-8500 PR_EXT:000013524 denotes Pygo2
T5599 9998-10002 PR_EXT:000001447 denotes Cdh1
T5598 9984-9994 GO:0042571 denotes Antibodies
T5597 9976-9982 UBERON:0007688 denotes anlage
T5596 9965-9975 UBERON:0000074 denotes glomerular
T5595 9946-9951 _FRAGMENT denotes renal
T5594 9946-9960 UBERON:0004209 denotes renal vesicles
T5593 9925-9933 GO:0042571 denotes antibody
T5592 9921-9924 PR_EXT:000017459 denotes WT1
T5591 9897-9914 UBERON:0006364 denotes ureteric bud tips
T5590 9855-9885 UBERON:0005107 denotes capping metanephric mesenchyme
T5589 9829-9839 GO:0042571 denotes antibodies
T6316 13141-13148 SO_EXT:sequence_altered_entity denotes mutants
T6315 13117-13122 PR_EXT:000013524 denotes Pygo2
T6314 13111-13116 PR_EXT:000013523 denotes Pygo1
T6313 13071-13076 PR_EXT:000017438 denotes Wnt11
T6312 12971-12984 GO:0097617 denotes hybridization
T6311 12924-12931 UBERON:0002113 denotes kidneys
T6310 12917-12923 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T6309 12904-12909 PR_EXT:000013524 denotes Pygo2
T6308 12898-12903 PR_EXT:000013523 denotes Pygo1
T6307 12892-12893 SO_EXT:normal_or_wild_type_or_present denotes +
T6306 12890-12891 SO_EXT:normal_or_wild_type_or_present denotes +
T6305 12885-12890 PR_EXT:000013524 denotes Pygo2
T6304 12862-12872 GO:0010467 denotes expression
T6303 12841-12846 SO_EXT:0000704 denotes genes
T6302 12813-12825 UBERON:0006364 denotes ureteric bud
T6301 12791-12798 _FRAGMENT denotes tips of
T6300 12813-12825 UBERON:0012238 denotes ureteric bud
T6299 12796-12798 _FRAGMENT denotes of
T6298 12766-12772 _FRAGMENT denotes stalks
T6297 12753-12758 PR_EXT:000017453 denotes Wnt9b
T6296 12726-12731 PR_EXT:000017438 denotes Wnt11
T6295 12696-12705 GO:0010467 denotes expressed
T6294 12687-12692 PR_EXT:000017449 denotes Wnt7b
T6293 12678-12685 SO_EXT:sequence_altered_entity denotes mutants
T6292 12673-12677 PR_EXT:Pygo denotes Pygo
T6291 12664-12669 SO_EXT:0000704 denotes genes
T6290 12640-12650 GO:0010467 denotes expression
T6289 12614-12627 GO:0097617 denotes hybridization
T9215 20907-20912 PR_EXT:000013523 denotes Pygo1
T15145 32110-32114 SO_EXT:0000704 denotes gene
T20009 41643-41648 PR_EXT:000013523 denotes Pygo1
T19103 41321-41338 UBERON:0006364 denotes Ureteric bud tips
T19102 41313-41319 UBERON:0000922 denotes embryo
T19101 41297-41304 UBERON:0002113 denotes kidneys
T19100 41193-41199 UBERON:0002113 denotes kidney
T19099 40999-41004 CHEBI_EXT:argon denotes argon
T19098 40890-40897 UBERON:0000479 denotes tissues
T19097 40860-40866 CHEBI_SO_EXT:molecular_probe denotes Probes
T19096 40850-40859 CHEBI_EXT:polyatomic_entity_or_group denotes Molecular
T19095 40838-40848 GO:0042571 denotes antibodies
T19094 40834-40837 NCBITaxon:10114 denotes rat
T19485 41600-41609 CHEBI_SO_EXT:riboprobe denotes riboprobe
T19484 41594-41599 PR_EXT:000017453 denotes Wnt9b
T20024 41858-41864 PR_EXT:000013524 denotes Pygo 2
T20023 41852-41857 NCBITaxon:9606 denotes human
T20022 41833-41841 CHEBI_EXT:residue denotes residues
T20021 41822-41832 CHEBI_SO_EXT:amino_acid denotes amino-acid
T20020 41793-41797 SO_EXT:cDNA denotes cDNA
T20019 41768-41778 GO:0042571 denotes antibodies
T20018 41749-41755 PR_EXT:Q9D0P5 denotes mPygo1
T20017 41737-41742 PR_EXT:000013523 denotes Pygo1
T20016 41731-41736 NCBITaxon:10088 denotes mouse
T20015 41714-41720 PR_EXT:Q9BRQ0 denotes hPygo2
T20014 41702-41707 PR_EXT:000013524 denotes Pygo2
T20013 41696-41701 NCBITaxon:9606 denotes human
T20012 41659-41678 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes antibody production
T20011 41659-41667 GO:0042571 denotes antibody
T20010 41653-41658 PR_EXT:000013524 denotes Pygo2
T20628 43398-43399 SO_EXT:sequence_nullness_or_absence denotes -
T20627 43393-43398 PR_EXT:000013523 denotes Pygo1
T20626 43378-43379 SO_EXT:sequence_nullness_or_absence denotes -
T20625 43376-43377 SO_EXT:normal_or_wild_type_or_present denotes +
T20624 43371-43376 PR_EXT:000013524 denotes Pygo2
T20623 43367-43368 SO_EXT:sequence_nullness_or_absence denotes -
T20622 43365-43366 SO_EXT:sequence_nullness_or_absence denotes -
T20621 43360-43365 PR_EXT:000013523 denotes Pygo1
T20620 43349-43350 SO_EXT:normal_or_wild_type_or_present denotes +
T20619 43347-43348 SO_EXT:normal_or_wild_type_or_present denotes +
T20618 43342-43347 PR_EXT:000013524 denotes Pygo2
T20617 43338-43339 SO_EXT:sequence_nullness_or_absence denotes -
T20616 43336-43337 SO_EXT:normal_or_wild_type_or_present denotes +
T20615 43331-43336 PR_EXT:000013523 denotes Pygo1
T20614 43311-43321 SO_EXT:transgenic_entity denotes transgenic
T20613 43249-43257 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T20612 43235-43242 CHEBI_PR_EXT:protein denotes protein
T20611 43146-43152 CHEBI_GO_SO_EXT:enzyme denotes Enzyme
T20610 43133-43138 GO_EXT:0004565 denotes β-Gal
T20609 43097-43107 GO:0010467 denotes expression
T20608 43091-43096 GO_EXT:0004565 denotes β-Gal
T20607 43081-43090 SO_EXT:0000902 denotes transgene
T20606 43053-43061 CHEBI:75958 denotes solution
T20605 43038-43043 CHEBI:75055 denotes X-gal
T20604 43007-43013 UBERON:0002113 denotes kidney
T20603 42960-42975 GO_EXT:0004565 denotes β-galactosidase
T20602 42872-42879 UBERON:0002113 denotes kidneys
T20601 42849-42856 UBERON:0000922 denotes embryos
T20600 42826-42831 CHEBI:75055 denotes X-gal
T20599 42802-42825 GO:0060070 denotes canonical Wnt signaling
T20598 42774-42783 SO_EXT:0000902 denotes transgene
T20597 42770-42773 GO_EXT:0015925 denotes gal
T21852 45831-45835 PR_EXT:000003676 denotes Actb
T21851 45709-45715 SO_EXT:0000112 denotes primer
T21850 45680-45687 CHEBI:2511 denotes agarose
T21849 45569-45579 CHEBI:51461 denotes SYBR Green
T21848 45362-45366 PR_EXT:000014395 denotes Ren2
T21847 45310-45315 PR_EXT:000013524 denotes Pygo2
T21846 45258-45264 PR_EXT:000029674 denotes Picalm
T21845 45207-45211 PR_EXT:000009415 denotes Klk5
T21844 45155-45160 PR_EXT:000005958 denotes Csrp1
T21843 45102-45108 PR_EXT:000005720 denotes Col8a1
T21842 45045-45052 PR_EXT:000004564 denotes Aldh1a7
T21841 44994-44998 PR_EXT:000003676 denotes Actb
T21840 44987-44992 CHEBI_SO_EXT:molecular_probe denotes probe
T21839 44951-44959 SO_EXT:biological_sequence denotes sequence
T21838 44913-44920 SO_EXT:0000112 denotes primers
T21837 44821-44829 CHEBI_SO_EXT:hexanucleotide denotes hexamers
T21836 44789-44793 SO_EXT:cDNA denotes cDNA
T21835 44771-44777 GO_PR_EXT:deoxyribonuclease_I denotes DNAse1
T21834 44712-44715 CHEBI_SO_EXT:RNA denotes RNA
T21833 44627-44634 UBERON:0002113 denotes kidneys
T21832 44566-44573 UBERON:0002113 denotes kidneys
T21831 44549-44553 SO_EXT:sequence_nullness denotes null
T21830 44543-44548 PR_EXT:000013524 denotes Pygo2
T21829 44537-44542 PR_EXT:000013523 denotes Pygo1
T22263 7346-7351 PR_EXT:000013523 denotes Pygo1
T22264 7352-7357 PR_EXT:000013524 denotes Pygo2
T22265 7358-7364 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22266 7365-7372 UBERON:0000922 denotes embryos
T22267 7384-7389 PR_EXT:000013523 denotes Pygo1
T22268 7389-7390 SO_EXT:sequence_nullness_or_absence denotes -
T22269 7391-7392 SO_EXT:sequence_nullness_or_absence denotes -
T22270 7393-7398 PR_EXT:000013524 denotes Pygo2
T22271 7398-7399 SO_EXT:normal_or_wild_type_or_present denotes +
T22272 7400-7401 SO_EXT:sequence_nullness_or_absence denotes -
T22273 7402-7409 UBERON:0000922 denotes embryos
T22274 7425-7434 SO_EXT:wild_type_entity_or_quality denotes wild-type
T22275 7435-7440 PR_EXT:000013524 denotes Pygo2
T22276 7441-7447 SO_EXT:0001023 denotes allele
T22277 7491-7497 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22278 7498-7503 PR_EXT:000013523 denotes Pygo1
T22279 7503-7504 SO_EXT:sequence_nullness_or_absence denotes -
T22280 7505-7506 SO_EXT:sequence_nullness_or_absence denotes -
T22281 7507-7512 PR_EXT:000013524 denotes Pygo2
T22282 7512-7513 SO_EXT:sequence_nullness_or_absence denotes -
T22283 7514-7515 SO_EXT:sequence_nullness_or_absence denotes -
T22284 7516-7523 UBERON:0000922 denotes embryos
T22285 7543-7546 UBERON:0000970 denotes eye
T22286 7587-7591 UBERON_EXT:lens denotes lens
T22287 7603-7612 CHEBI_EXT:26130 denotes pigmented
T22288 7613-7619 UBERON:0000966 denotes retina
T22289 7656-7661 PR_EXT:000013523 denotes Pygo1
T22290 7662-7667 PR_EXT:000013524 denotes Pygo2
T22291 7668-7672 SO_EXT:sequence_nullness denotes null
T22292 7673-7680 UBERON:0000922 denotes embryos
T23089 10354-10355 SO_EXT:sequence_nullness_or_absence denotes -
T23088 10352-10353 SO_EXT:sequence_nullness_or_absence denotes -
T23087 10347-10352 PR_EXT:000013523 denotes Pygo1
T23086 10331-10338 UBERON:0002113 denotes kidneys
T23085 10318-10324 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T23084 10312-10317 PR_EXT:000013524 denotes Pygo2
T23083 10306-10311 PR_EXT:000013523 denotes Pygo1
T24196 14644-14649 PR_EXT:000013523 denotes Pygo1
T24195 14631-14638 UBERON:0002329 denotes somites
T24194 14608-14622 UBERON:0005418 denotes hind limb buds
T24193 14613-14622 UBERON:0005417 denotes limb buds
T24192 14599-14603 _FRAGMENT denotes fore
T24191 14567-14591 UBERON:0004356 denotes apical ectodermal ridges
T24190 14553-14565 UBERON:0003051 denotes otic vesicle
T24189 14533-14551 UBERON:0004117 denotes pharyngeal pouches
T24188 14526-14531 UBERON:0000955 denotes brain
T24187 14493-14498 CHEBI:75055 denotes X-gal
T24186 14471-14478 UBERON:0000922 denotes embryos
T24185 14469-14470 SO_EXT:sequence_nullness_or_absence denotes -
T24184 14467-14468 SO_EXT:normal_or_wild_type_or_present denotes +
T24183 14462-14467 PR_EXT:000013524 denotes Pygo2
T24182 14460-14461 SO_EXT:normal_or_wild_type_or_present denotes +
T24181 14458-14459 SO_EXT:normal_or_wild_type_or_present denotes +
T27417 7732-7737 PR_EXT:000013524 denotes Pygo2
T26905 21984-21994 GO:0010467 denotes expression
T26904 21980-21983 GO_EXT:0015925 denotes gal
T26903 21939-21946 UBERON:0002113 denotes kidneys
T26902 21937-21938 SO_EXT:normal_or_wild_type_or_present denotes +
T26901 21935-21936 SO_EXT:normal_or_wild_type_or_present denotes +
T26900 21930-21935 PR_EXT:000013524 denotes Pygo2
T26899 21928-21929 SO_EXT:sequence_nullness_or_absence denotes -
T26898 21926-21927 SO_EXT:normal_or_wild_type_or_present denotes +
T26897 21921-21926 PR_EXT:000013523 denotes Pygo1
T26896 21915-21916 SO_EXT:sequence_nullness_or_absence denotes -
T26895 21913-21914 SO_EXT:normal_or_wild_type_or_present denotes +
T26894 21908-21913 PR_EXT:000013524 denotes Pygo2
T26893 21906-21907 SO_EXT:sequence_nullness_or_absence denotes -
T26892 21904-21905 SO_EXT:normal_or_wild_type_or_present denotes +
T26891 21899-21904 PR_EXT:000013523 denotes Pygo1
T26890 21896-21897 SO_EXT:normal_or_wild_type_or_present denotes +
T26889 21894-21895 SO_EXT:normal_or_wild_type_or_present denotes +
T26888 21889-21894 PR_EXT:000013524 denotes Pygo2
T26887 21887-21888 SO_EXT:sequence_nullness_or_absence denotes -
T26886 21885-21886 SO_EXT:normal_or_wild_type_or_present denotes +
T26885 21880-21885 PR_EXT:000013523 denotes Pygo1
T26884 21827-21845 GO_EXT:0004565 denotes beta-galactosidase
T26883 21808-21817 SO_EXT:0000902 denotes Transgene
T26882 21791-21797 UBERON:0002113 denotes kidney
T26881 21779-21784 PR_EXT:000013524 denotes Pygo2
T26880 21773-21778 PR_EXT:000013523 denotes Pygo1
T26879 21759-21769 GO:0010467 denotes expression
T26878 21746-21749 GO_EXT:0015925 denotes gal
T27256 28557-28570 GO:0016055 denotes Wnt signaling
T27255 28523-28538 GO:0010467 denotes Gene expression
T27254 28523-28527 SO_EXT:0000704 denotes Gene
T27253 28883-28893 GO:0010467 denotes expression
T27418 7738-7747 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27419 7768-7772 SO_EXT:sequence_nullness denotes null
T27420 7779-7786 UBERON:0000922 denotes embryos
T27421 7792-7797 PR_EXT:000013523 denotes Pygo1
T27422 7798-7802 SO_EXT:sequence_nullness denotes null
T27486 11720-11724 SO_EXT:sequence_nullness denotes null
T27485 11714-11719 PR_EXT:000013523 denotes Pygo1
T27484 11699-11706 UBERON:0002113 denotes kidneys
T27483 11688-11692 SO_EXT:sequence_nullness denotes null
T27482 11659-11668 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27481 11653-11658 PR_EXT:000013524 denotes Pygo2
T27654 29604-29611 UBERON:0002113 denotes kidneys
T27653 29594-29603 SO_EXT:wild_type_entity_or_quality denotes wild-type
T27652 29566-29573 UBERON:0002113 denotes kidneys
T27651 29561-29565 SO_EXT:sequence_nullness denotes null
T27650 29555-29560 PR_EXT:000013524 denotes Pygo2
T27649 29549-29554 PR_EXT:000013523 denotes Pygo1
T27648 29512-29527 GO:0010467 denotes gene expression
T27647 29512-29516 SO_EXT:0000704 denotes gene
T11955 24843-24849 UBERON:0009773 denotes kidney
T11954 24822-24832 _FRAGMENT denotes tubules of
T5588 9816-9822 PR_EXT:000005505 denotes Cited1
T5587 9802-9805 PR_EXT:000017459 denotes Wt1
T5586 9767-9774 UBERON:0002113 denotes kidneys
T5585 9762-9766 SO_EXT:sequence_nullness denotes null
T5584 9756-9761 PR_EXT:000013524 denotes Pygo2
T5583 9750-9755 PR_EXT:000013523 denotes Pygo1
T5582 9723-9740 GO:0001822 denotes renal development
T5581 9723-9728 UBERON:0002113 denotes renal
T5580 9633-9646 GO:0001822 denotes nephrogenesis
T5579 9589-9596 UBERON:0002113 denotes kidneys
T5578 9582-9588 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5577 9577-9581 SO_EXT:sequence_nullness denotes null
T5576 9564-9569 PR_EXT:000013524 denotes Pygo2
T5575 9558-9563 PR_EXT:000013523 denotes Pygo1
T5574 9549-9553 SO_EXT:sequence_nullness denotes null
T5573 9543-9548 PR_EXT:000013524 denotes Pygo2
T5572 9507-9514 UBERON:0002113 denotes kidneys
T5571 9500-9506 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5570 9494-9499 PR_EXT:000013524 denotes Pygo2
T5569 9488-9493 PR_EXT:000013523 denotes Pygo1
T5625 11565-11584 UBERON:0004198 denotes comma-shaped bodies
T5624 11549-11563 UBERON:0004209 denotes renal vesicles
T5623 11524-11537 GO:0001822 denotes nephrogenesis
T5622 11478-11484 UBERON:0000362 denotes kidney
T5621 11463-11473 _FRAGMENT denotes medulla of
T5620 11417-11434 UBERON:0006364 denotes ureteric bud tips
T5619 11367-11375 UBERON:0001285 denotes nephrons
T5618 11353-11357 PR_EXT:000001447 denotes Cdh1
T5617 11338-11351 GO:0001822 denotes nephrogenesis
T5616 11287-11309 UBERON:0003220 denotes metanephric mesenchyme
T5615 11280-11286 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5614 11227-11240 UBERON:0000084 denotes ureteric buds
T5613 11220-11226 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5612 11185-11203 UBERON:0005107 denotes capping mesenchyme
T5611 11119-11121 UBERON:0000084 denotes re
T836 10-15 PR_EXT:000013524 denotes Pygo2
T867 610-614 GO:0016265 denotes died
T11960 24926-24933 UBERON:0001285 denotes nephron
T11959 24899-24904 SO_EXT:0000704 denotes genes
T11958 24893-24898 PR_EXT:000013524 denotes Pygo2
T11957 24887-24892 PR_EXT:000013523 denotes Pygo1
T11956 24837-24842 UBERON:0007023 denotes adult
T12038 29378-29383 SO_EXT:0000704 denotes genes
T12037 29193-29198 SO_EXT:0000704 denotes genes
T12036 29132-29142 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T12035 28504-28511 UBERON:0002113 denotes kidneys
T12034 28497-28503 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T12033 28491-28496 PR_EXT:000013524 denotes Pygo2
T9040 15411-15412 UBERON:0000922 denotes e
T9039 15408-15409 SO_EXT:0000902 denotes s
T9038 15404-15405 UBERON:0000922 denotes e
T9037 15403-15404 GO:0060070 denotes W
T9036 14274-14281 UBERON:0000467 denotes systems
T9035 14215-14238 GO:0060070 denotes canonical Wnt signaling
T9034 14201-14211 GO_EXT:regulator denotes modulators
T9033 14179-14184 SO_EXT:0000704 denotes genes
T9032 14174-14178 PR_EXT:Pygo denotes Pygo
T9031 14164-14173 NCBITaxon:40674 denotes mammalian
T9030 14118-14131 GO:0016055 denotes Wnt signaling
T9029 14084-14097 UBERON:0001893 denotes telencephalon
T9028 14077-14083 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9027 14019-14026 UBERON:0002329 denotes somites
T9026 13954-13960 UBERON:0000479 denotes tissue
T9025 13898-13921 GO:0060070 denotes canonical Wnt signaling
T9024 13869-13876 UBERON:0000922 denotes embryos
T9023 13858-13862 SO_EXT:sequence_nullness denotes null
T9022 13845-13850 PR_EXT:000013524 denotes Pygo2
T9021 13839-13844 PR_EXT:000013523 denotes Pygo1
T9020 13833-13834 SO_EXT:sequence_nullness_or_absence denotes -
T9019 13831-13832 SO_EXT:sequence_nullness_or_absence denotes -
T9018 13826-13831 PR_EXT:000013524 denotes Pygo2
T9017 13815-13819 NCBITaxon:10088 denotes mice
T9016 13808-13814 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9015 13787-13800 GO:0016055 denotes Wnt signaling
T9014 13727-13750 GO:0060070 denotes canonical Wnt signaling
T9013 13705-13714 SO_EXT:0000902 denotes transgene
T9012 13701-13704 GO_EXT:0015925 denotes gal
T9011 13688-13692 NCBITaxon:10088 denotes mice
T9010 13681-13687 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9009 13675-13680 PR_EXT:000013524 denotes Pygo2
T9008 13669-13674 PR_EXT:000013523 denotes Pygo1
T9007 13642-13665 GO:0060070 denotes canonical Wnt signaling
T9059 15630-15634 SO_EXT:sequence_nullness denotes null
T9058 15624-15629 PR_EXT:000013524 denotes Pygo2
T9057 15605-15617 UBERON:0009201 denotes nephric duct
T9056 15574-15597 GO:0060070 denotes canonical Wnt signaling
T9055 15553-15557 SO_EXT:0000704 denotes gene
T9054 15547-15552 PR_EXT:000013524 denotes Pygo2
T9053 15507-15514 SO_EXT:sequence_altered_entity denotes mutants
T9052 15502-15506 PR_EXT:Pygo denotes Pygo
T9051 15481-15498 UBERON:0004122 denotes urogenital system
T9050 15442-15447 GO:0010467 denotes ssion
T9049 15433-15434 GO:0060070 denotes t
T9048 15430-15432 GO:0010467 denotes po
T9047 15428-15430 GO:0010467 denotes re
T9046 15424-15427 GO_EXT:0015925 denotes gal
T9045 15418-15419 SO_EXT:wild_type_entity_or_quality denotes d
T9044 15417-15418 SO_EXT:0001023 denotes e
T9043 15416-15417 SO_EXT:sequence_alteration_entity_or_process denotes n
T9042 15414-15416 UBERON:0002329 denotes mi
T9041 15412-15413 GO:0010467 denotes x
T9074 15975-15985 GO:0010467 denotes expression
T9073 15962-15965 GO_EXT:0015925 denotes gal
T9072 15898-15910 UBERON:0000084 denotes ureteric bud
T9071 15845-15857 UBERON:0009201 denotes nephric duct
T9070 15832-15839 SO_EXT:sequence_altered_entity denotes mutants
T9069 15827-15831 SO_EXT:sequence_nullness denotes null
T9068 15814-15819 PR_EXT:000013524 denotes Pygo2
T9067 15808-15813 PR_EXT:000013523 denotes Pygo1
T9066 15779-15789 GO:0010467 denotes expression
T9065 15725-15737 UBERON:0009201 denotes nephric duct
T9064 15707-15717 GO:0010467 denotes expression
T9063 15669-15676 UBERON:0000922 denotes embryos
T9062 15658-15662 SO_EXT:sequence_nullness denotes null
T9061 15645-15650 PR_EXT:000013524 denotes Pygo2
T9060 15639-15644 PR_EXT:000013523 denotes Pygo1
T9078 18558-18559 PR_EXT:000013523 denotes y
T9077 18545-18547 GO:0010467 denotes pe
T9076 18539-18540 UBERON:0000922 denotes e
T9075 18532-18537 PR_EXT:000013524 denotes Pygo2
T9086 18734-18737 GO_EXT:0015925 denotes gal
T9085 18710-18716 UBERON:0002113 denotes kidney
T9084 18679-18689 GO:0010467 denotes expression
T9083 18675-18678 GO_EXT:0015925 denotes gal
T9082 18641-18649 UBERON:0000056 denotes ureteric
T9081 18610-18633 GO:0060070 denotes canonical Wnt signaling
T9080 18588-18592 SO_EXT:0000704 denotes gene
T9079 18582-18587 PR_EXT:000013523 denotes Pygo1
T9172 20253-20258 CHEBI:75055 denotes X-gal
T9291 22819-22823 PR_EXT:000017435 denotes Wnt1
T9290 22805-22815 GO:0010467 denotes expression
T9289 22792-22804 UBERON:0000084 denotes ureteric bud
T9288 22755-22777 UBERON:0003220 denotes metanephric mesenchyme
T9287 22724-22747 GO:0060070 denotes canonical Wnt signaling
T9286 22632-22654 UBERON:0003220 denotes metanephric mesenchyme
T9285 22601-22624 GO:0060070 denotes canonical Wnt signaling
T9284 22478-22493 UBERON:0004199 denotes S-shaped bodies
T9283 22508-22517 UBERON:0000074 denotes glomeruli
T9282 22495-22502 UBERON:0009773 denotes tubules
T9281 22462-22467 _FRAGMENT denotes renal
T9280 22462-22476 UBERON:0004209 denotes renal vesicles
T9279 22411-22433 UBERON:0003220 denotes metanephric mesenchyme
T9278 22384-22406 UBERON:0003220 denotes metanephric mesenchyme
T9277 22355-22365 GO:0010467 denotes expression
T9276 22332-22335 GO_EXT:0015925 denotes gal
T9275 22319-22323 NCBITaxon:10088 denotes mice
T9274 22309-22318 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9273 21699-21705 UBERON:0002113 denotes kidney
T9272 21678-21686 UBERON:0000056 denotes ureteric
T9271 21628-21651 GO:0060070 denotes canonical Wnt signaling
T9270 21619-21624 SO_EXT:0000704 denotes genes
T9269 21613-21618 PR_EXT:000013524 denotes Pygo2
T9268 21603-21608 PR_EXT:000013523 denotes Pygo1
T9267 21547-21550 GO_EXT:0015925 denotes gal
T9266 21497-21504 UBERON:0002113 denotes kidneys
T9265 21495-21496 SO_EXT:normal_or_wild_type_or_present denotes +
T9264 21493-21494 SO_EXT:normal_or_wild_type_or_present denotes +
T9263 21488-21493 PR_EXT:000013524 denotes Pygo2
T9262 21486-21487 SO_EXT:sequence_nullness_or_absence denotes -
T9261 21484-21485 SO_EXT:sequence_nullness_or_absence denotes -
T9260 21479-21484 PR_EXT:000013523 denotes Pygo1
T9259 21436-21448 UBERON:0006364 denotes ureteric tip
T9258 21396-21409 UBERON:0006364 denotes ureteric tips
T9257 21367-21375 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T9256 21349-21356 UBERON:0002113 denotes kidneys
T9255 21320-21326 UBERON:0002113 denotes kidney
T9254 21318-21319 SO_EXT:sequence_nullness_or_absence denotes -
T9253 21316-21317 SO_EXT:normal_or_wild_type_or_present denotes +
T9298 22985-22988 GO_EXT:0015925 denotes gal
T15288 36422-36445 GO:0060070 denotes canonical Wnt signaling
T15287 36383-36389 UBERON:0002113 denotes kidney
T15286 36350-36360 GO:0010467 denotes expression
T15285 36317-36322 SO_EXT:0000704 denotes genes
T15284 36274-36292 GO:0001822 denotes kidney development
T15283 36274-36280 UBERON:0002113 denotes kidney
R4 T924 T923 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R5 T940 T939 _lexicallyChainedTo of,transducers
R6 T941 T940 _lexicallyChainedTo signal intensity,of
R396 T2569 T2568 _lexicallyChainedTo complex,formation of
R397 T2626 T2625 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R1256 T4626 T4625 _lexicallyChainedTo kidney,cells of
R1385 T5596 T5595 _lexicallyChainedTo glomerular,renal
R1386 T5622 T5621 _lexicallyChainedTo kidney,medulla of
R1736 T6299 T6298 _lexicallyChainedTo of,stalks
R1737 T6300 T6299 _lexicallyChainedTo ureteric bud,of
R1738 T6302 T6301 _lexicallyChainedTo ureteric bud,tips of
R1854 T9122 T9121 _lexicallyChainedTo ducts,paramesonephric
R1855 T9165 T9164 _lexicallyChainedTo kidney,cortex of
R1856 T9175 T9174 _lexicallyChainedTo of,collecting ducts
R1857 T9176 T9175 _lexicallyChainedTo kidney,of
R1874 T9282 T9281 _lexicallyChainedTo tubules,renal
R1876 T9283 T9281 _lexicallyChainedTo glomeruli,renal
R3016 T11955 T11954 _lexicallyChainedTo kidney,tubules of
R3620 T15067 T15066 _lexicallyChainedTo development,central nervous system
R3621 T15182 T15181 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R3622 T15195 T15194 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R4721 T17067 T17066 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R4722 T17090 T17089 _lexicallyChainedTo signaling,transducers of
R4993 T18108 T18107 _lexicallyChainedTo exon,coding regions of
R6483 T22619 T22618 _lexicallyChainedTo kidney,cortex of
R6860 T24193 T24192 _lexicallyChainedTo limb buds,fore
R3 T903 T902 _lexicallyChainedTo ureteric bud,Branching morphogenesis of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T27241 28592-28597 PR:000013523 denotes Pygo1
T27240 28557-28570 GO:0016055 denotes Wnt signaling
T27239 28523-28538 GO:0010467 denotes Gene expression
T27238 28523-28527 SO:0000704 denotes Gene
T27564 25079-25085 UBERON:0002113 denotes kidney
T27563 25062-25067 PR:000013524 denotes Pygo2
T27562 25056-25061 PR:000013523 denotes Pygo1
T26870 21984-21994 GO:0010467 denotes expression
T26869 21939-21946 UBERON:0002113 denotes kidneys
T26868 21930-21935 PR:000013524 denotes Pygo2
T26867 21921-21926 PR:000013523 denotes Pygo1
T26866 21908-21913 PR:000013524 denotes Pygo2
T26865 21899-21904 PR:000013523 denotes Pygo1
T26864 21889-21894 PR:000013524 denotes Pygo2
T26863 21880-21885 PR:000013523 denotes Pygo1
T26862 21808-21817 SO:0000902 denotes Transgene
T26861 21791-21797 UBERON:0002113 denotes kidney
T26860 21779-21784 PR:000013524 denotes Pygo2
T26859 21773-21778 PR:000013523 denotes Pygo1
T26858 21759-21769 GO:0010467 denotes expression
T25759 18409-18415 UBERON:0002113 denotes kidney
T25758 18392-18397 PR:000013524 denotes Pygo2
T25757 18383-18388 PR:000013523 denotes Pygo1
T25756 18358-18365 UBERON:0002113 denotes kidneys
T25755 18340-18345 PR:000013524 denotes Pygo2
T25754 18331-18336 PR:000013523 denotes Pygo1
T25753 18311-18316 PR:000013524 denotes Pygo2
T25752 18302-18307 PR:000013523 denotes Pygo1
T25751 18273-18281 UBERON:0000056 denotes ureteric
T25750 18227-18234 UBERON:0002113 denotes kidneys
T25749 18204-18209 PR:000013524 denotes Pygo2
T25748 18195-18200 PR:000013523 denotes Pygo1
T25747 18172-18177 PR:000013524 denotes Pygo2
T25746 18163-18168 PR:000013523 denotes Pygo1
T25745 18146-18151 PR:000013524 denotes Pygo2
T25744 18137-18142 PR:000013523 denotes Pygo1
T25743 18032-18039 UBERON:0000958 denotes medulla
T25742 18021-18027 UBERON:0001851 denotes cortex
T25741 17989-17997 UBERON:0000056 denotes ureteric
T25740 17962-17972 GO:0010467 denotes expression
T25739 17915-17922 UBERON:0002113 denotes kidneys
T25738 17902-17909 UBERON:0002113 denotes kidneys
T25737 17879-17884 PR:000013524 denotes Pygo2
T25736 17870-17875 PR:000013523 denotes Pygo1
T25735 17850-17855 PR:000013524 denotes Pygo2
T25734 17841-17846 PR:000013523 denotes Pygo1
T25733 17763-17770 UBERON:0002113 denotes kidneys
T25732 17724-17732 UBERON:0000056 denotes ureteric
T25731 17713-17719 UBERON:0000056 denotes ureter
T25730 17662-17682 UBERON:0003890 denotes paramesonephric duct
T25729 17618-17623 PR:000013524 denotes Pygo2
T25728 17609-17614 PR:000013523 denotes Pygo1
T25727 17581-17601 UBERON:0003890 denotes paramesonephric duct
T25693 16616-16622 UBERON:0000922 denotes embryo
T25692 16608-16612 PR:000013524 denotes Pygo
T25691 16599-16604 PR:000013523 denotes Pygo1
T25690 16567-16579 UBERON:0000084 denotes ureteric bud
T25689 16532-16544 UBERON:0009201 denotes nephric duct
T25688 16487-16493 UBERON:0000922 denotes embryo
T25687 16472-16477 PR:000013524 denotes Pygo2
T25686 16463-16468 PR:000013523 denotes Pygo1
T25685 16443-16449 UBERON:0000922 denotes embryo
T25684 16432-16437 PR:000013524 denotes Pygo2
T25683 16398-16410 UBERON:0000084 denotes ureteric bud
T25682 16334-16346 UBERON:0009201 denotes nephric duct
T25681 16274-16279 PR:000013524 denotes Pygo2
T25680 16265-16270 PR:000013523 denotes Pygo1
T25679 16245-16250 PR:000013524 denotes Pygo2
T25678 16236-16241 PR:000013523 denotes Pygo1
T25677 16223-16230 UBERON:0002113 denotes kidneys
T25676 16188-16198 UBERON:0004122 denotes urogenital
T25674 16114-16120 UBERON:0002113 denotes kidney
T25673 16064-16076 UBERON:0000084 denotes ureteric bud
T25672 16050-16060 GO:0010467 denotes expression
T25671 16011-16016 PR:000013524 denotes Pygo2
T24169 15225-15232 UBERON:0000922 denotes embryos
T24168 15131-15138 UBERON:0000922 denotes Embryos
T24167 15106-15129 GO:0060070 denotes canonical Wnt signaling
T24166 15074-15084 GO:0010467 denotes expression
T24165 15030-15037 UBERON:0000922 denotes embryos
T24164 15021-15026 PR:000013524 denotes Pygo2
T24163 15012-15017 PR:000013523 denotes Pygo1
T24162 14971-14981 GO:0010467 denotes expression
T24161 14941-14947 SO:0001023 denotes allele
T24160 14935-14940 PR:000013524 denotes Pygo2
T24159 14908-14915 SO:0001023 denotes alleles
T24158 14902-14907 PR:000013523 denotes Pygo1
T24157 14872-14878 UBERON:0000922 denotes embryo
T24156 14863-14868 PR:000013524 denotes Pygo2
T24155 14854-14859 PR:000013523 denotes Pygo1
T24154 14841-14848 UBERON:0002329 denotes somites
T24153 14823-14835 UBERON:0003051 denotes otic vesicle
T24152 14803-14821 UBERON:0004117 denotes pharyngeal pouches
T24151 14751-14761 GO:0010467 denotes expression
T24150 14695-14702 SO:0001023 denotes alleles
T24149 14689-14694 PR:000013524 denotes Pygo2
T24148 14662-14669 UBERON:0000922 denotes embryos
T24147 14653-14658 PR:000013524 denotes Pygo2
T24146 14644-14649 PR:000013523 denotes Pygo1
T24145 14631-14638 UBERON:0002329 denotes somites
T24144 14608-14622 UBERON:0005418 denotes hind limb buds
T24143 14613-14622 UBERON:0005417 denotes limb buds
T24142 14599-14603 _FRAGMENT denotes fore
T24141 14567-14591 UBERON:0004356 denotes apical ectodermal ridges
T24140 14553-14565 UBERON:0003051 denotes otic vesicle
T24139 14533-14551 UBERON:0004117 denotes pharyngeal pouches
T24138 14526-14531 UBERON:0000955 denotes brain
T24137 14493-14498 CHEBI:75055 denotes X-gal
T24136 14471-14478 UBERON:0000922 denotes embryos
T24135 14462-14467 PR:000013524 denotes Pygo2
T24134 14453-14458 PR:000013523 denotes Pygo1
T24133 14424-14447 GO:0060070 denotes canonical Wnt signaling
T24132 14402-14411 SO:0000902 denotes transgene
T24131 14372-14379 UBERON:0000922 denotes embryos
T24130 14357-14364 UBERON:0000922 denotes embryos
T24129 14344-14349 PR:000013524 denotes Pygo2
T24128 14338-14343 PR:000013523 denotes Pygo1
T24127 14328-14333 PR:000013524 denotes Pygo2
T24126 14301-14324 GO:0060070 denotes canonical Wnt signaling
T23532 13597-13602 PR:000017438 denotes Wnt11
T23531 13568-13581 UBERON:0006364 denotes ureteric tips
T23530 13538-13543 PR:000017453 denotes Wnt9b
T23529 13528-13533 PR:000017449 denotes Wnt7b
T23528 13505-13519 UBERON:0012238 denotes ureteric stalk
T23527 13477-13487 GO:0010467 denotes expression
T23526 13455-13462 UBERON:0002113 denotes kidneys
T23525 13437-13442 PR:000017438 denotes Wnt11
T23524 13419-13424 PR:000017453 denotes Wnt9b
T23523 13405-13410 PR:000017449 denotes Wnt7b
T23522 13365-13377 UBERON:0000084 denotes ureteric bud
T23521 13348-13355 UBERON:0002113 denotes kidneys
T23520 13332-13337 PR:000013524 denotes Pygo2
T23519 13323-13328 PR:000013523 denotes Pygo1
T23518 13305-13312 UBERON:0002113 denotes kidneys
T23517 13265-13279 GO:0097617 denotes hybridizations
T23516 13233-13240 UBERON:0002113 denotes kidneys
T23515 13213-13218 PR:000013524 denotes Pygo2
T23514 13207-13212 PR:000013523 denotes Pygo1
T23513 13192-13197 PR:000017438 denotes Wnt11
T23512 13181-13186 PR:000017453 denotes Wnt9b
T23511 13174-13179 PR:000017449 denotes Wnt7b
T23510 13160-13170 GO:0010467 denotes Expression
T22609 9426-9434 GO:0042571 denotes antibody
T22608 9415-9425 PR:000001447 denotes E-cadherin
T22607 9359-9371 UBERON:0000084 denotes ureteric bud
T22606 9331-9347 CL:0000066 denotes Epithelial cells
T22605 9331-9341 UBERON:0000483 denotes Epithelial
T22604 9296-9308 CL:0000499 denotes stromal cell
T22603 9296-9303 UBERON:0003891 denotes stromal
T22602 9256-9262 UBERON:0002113 denotes kidney
T22601 9187-9197 GO:0010467 denotes expression
T22600 9163-9168 SO:0000704 denotes genes
T22599 9136-9143 GO:0005634 denotes nucleus
T22598 9102-9107 PR:000013524 denotes Pygo2
T22597 9092-9097 PR:000013523 denotes Pygo1
T22596 9079-9085 UBERON:0001225 denotes kidney
T22595 9059-9068 _FRAGMENT denotes cortex of
T22594 9037-9042 PR:000013524 denotes Pygo2
T22593 9027-9032 PR:000013523 denotes Pygo1
T22592 9000-9010 GO:0010467 denotes expression
T22591 8951-8957 UBERON:0002113 denotes kidney
T22590 8916-8926 GO:0010467 denotes expression
T22589 8910-8915 PR:000013524 denotes Pygo2
T22588 8900-8905 PR:000013523 denotes Pygo1
T21827 45831-45835 PR:000003676 denotes Actb
T21826 45709-45715 SO:0000112 denotes primer
T21825 45680-45687 CHEBI:2511 denotes agarose
T21824 45569-45579 CHEBI:51461 denotes SYBR Green
T21823 45362-45366 PR:000014395 denotes Ren2
T21822 45310-45315 PR:000013524 denotes Pygo2
T21821 45258-45264 PR:000029674 denotes Picalm
T21820 45207-45211 PR:000009415 denotes Klk5
T21819 45155-45160 PR:000005958 denotes Csrp1
T21818 45102-45108 PR:000005720 denotes Col8a1
T21817 45045-45052 PR:000004564 denotes Aldh1a7
T21816 44994-44998 PR:000003676 denotes Actb
T21815 44913-44920 SO:0000112 denotes primers
T21814 44627-44634 UBERON:0002113 denotes kidneys
T21813 44566-44573 UBERON:0002113 denotes kidneys
T21812 44543-44548 PR:000013524 denotes Pygo2
T21811 44537-44542 PR:000013523 denotes Pygo1
T21164 44438-44443 SO:0000704 denotes genes
T21163 44281-44286 SO:0000704 denotes Genes
T21162 44051-44058 UBERON:0002113 denotes kidneys
T21161 44019-44024 PR:000013524 denotes Pygo2
T21160 44013-44018 PR:000013523 denotes Pygo1
T21159 43936-43959 SO:0000345 denotes expressed sequence tags
T21158 43936-43945 GO:0010467 denotes expressed
T21157 43926-43931 SO:0000704 denotes genes
T21156 43847-43857 GO:0010467 denotes expression
T21155 43839-43844 NCBITaxon:10088 denotes Mouse
T21154 43804-43814 GO:0097617 denotes hybridized
T21153 43544-43551 UBERON:0000922 denotes embryos
T21152 43524-43529 PR:000013524 denotes Pygo2
T20592 43342-43347 PR:000013524 denotes Pygo2
T20591 43331-43336 PR:000013523 denotes Pygo1
T20589 43081-43090 SO:0000902 denotes transgene
T20588 43053-43061 CHEBI:75958 denotes solution
T20587 43038-43043 CHEBI:75055 denotes X-gal
T20586 43007-43013 UBERON:0002113 denotes kidney
T20585 42872-42879 UBERON:0002113 denotes kidneys
T20584 42849-42856 UBERON:0000922 denotes embryos
T20583 42826-42831 CHEBI:75055 denotes X-gal
T20582 42802-42825 GO:0060070 denotes canonical Wnt signaling
T20581 42774-42783 SO:0000902 denotes transgene
T19996 42392-42398 PR:Q9BRQ0 denotes hPygo2
T19995 42378-42381 PR:000022850 denotes GST
T19994 42359-42369 GO:0042571 denotes antibodies
T19993 42325-42328 PR:000022850 denotes GST
T19992 42280-42286 PR:Q9BRQ0 denotes hPygo2
T19991 42264-42270 PR:Q9D0P5 denotes mPygo1
T19990 42251-42255 UBERON:0001977 denotes sera
T19989 42240-42246 NCBITaxon:9986 denotes rabbit
T19988 42169-42177 GO:0042571 denotes antibody
T19987 42157-42164 NCBITaxon:9986 denotes rabbits
T19986 42119-42127 NCBITaxon:2 denotes bacteria
T19985 42106-42115 GO:0010467 denotes expressed
T19984 42085-42091 PR:Q9D0P5 denotes mPygo1
T19983 42081-42084 PR:000022850 denotes GST
T19982 42070-42076 PR:Q9BRQ0 denotes hPygo2
T19981 42066-42069 PR:000022850 denotes GST
T19980 42058-42064 PR:Q9D0P5 denotes mPygo1
T19979 42047-42053 PR:Q9BRQ0 denotes hPygo2
T19978 41996-42003 PR:Q9D0P5 denotes mPygo 1
T19977 41984-41991 PR:Q9BRQ0 denotes hPygo 2
T19976 41904-41909 PR:000013523 denotes Pygo1
T19975 41898-41903 NCBITaxon:10088 denotes mouse
T19974 41858-41864 PR:000013524 denotes Pygo 2
T19973 41852-41857 NCBITaxon:9606 denotes human
T19972 41768-41778 GO:0042571 denotes antibodies
T19971 41749-41755 PR:Q9D0P5 denotes mPygo1
T19970 41737-41742 PR:000013523 denotes Pygo1
T19969 41731-41736 NCBITaxon:10088 denotes mouse
T19968 41714-41720 PR:Q9BRQ0 denotes hPygo2
T19967 41702-41707 PR:000013524 denotes Pygo2
T19966 41696-41701 NCBITaxon:9606 denotes human
T19965 41659-41667 GO:0042571 denotes antibody
T19964 41653-41658 PR:000013524 denotes Pygo2
T19963 41643-41648 PR:000013523 denotes Pygo1
T19478 41594-41599 PR:000017453 denotes Wnt9b
T19477 41552-41557 PR:000017449 denotes Wnt7b
T19476 41542-41547 PR:000017438 denotes Wnt11
T19475 41470-41483 GO:0097617 denotes hybridization
T19474 41436-41449 GO:0097617 denotes hybridization
T19068 41321-41338 UBERON:0006364 denotes Ureteric bud tips
T19067 41313-41319 UBERON:0000922 denotes embryo
T19066 41297-41304 UBERON:0002113 denotes kidneys
T19065 41193-41199 UBERON:0002113 denotes kidney
T19064 40890-40897 UBERON:0000479 denotes tissues
T19063 40838-40848 GO:0042571 denotes antibodies
T19062 40834-40837 NCBITaxon:10114 denotes rat
T19061 40818-40828 MOP:0000779 denotes conjugated
T19060 40797-40803 NCBITaxon:9986 denotes rabbit
T19059 40781-40791 MOP:0000779 denotes conjugated
T19058 40771-40780 CHEBI:52673 denotes Alexa 555
T19057 40755-40765 GO:0042571 denotes antibodies
T19056 40679-40685 PR:000005505 denotes Cited1
T19055 40629-40633 PR:000001447 denotes Cdh1
T19054 40617-40627 PR:000001447 denotes e-cadherin
T19053 40605-40615 PR:000001447 denotes uvomorulin
T19052 40541-40544 PR:000017459 denotes WT1
T19051 40520-40530 GO:0042571 denotes antibodies
T19050 40496-40506 GO:0042571 denotes antibodies
T19049 40456-40461 UBERON:0001977 denotes serum
T19048 40451-40455 NCBITaxon:9925 denotes goat
T19047 40373-40390 NCBITaxon:271171 denotes Dilichos biflorus
T19046 40362-40372 MOP:0000779 denotes conjugated
T19045 40350-40361 CHEBI:31624 denotes fluoroscein
T19044 40337-40344 UBERON:0000479 denotes tissues
T19043 40303-40304 CHEBI:53424 denotes T
T19042 40287-40297 GO:0042571 denotes antibodies
T19041 40248-40249 CHEBI:53424 denotes T
T19040 40234-40242 CHEBI:53424 denotes Tween-20
T19039 40193-40201 CHEBI:17790 denotes methanol
T19038 40129-40136 UBERON:0002113 denotes Kidneys
T18100 40059-40072 UBERON:0010148 denotes vaginal plugs
T18099 40008-40009 SO:0001031 denotes R
T18098 39978-39979 SO:0001030 denotes F
T18097 39970-39976 SO:0001023 denotes allele
T18096 39963-39969 SO:0000359 denotes floxed
T18095 39951-39956 PR:000013523 denotes Pygo1
T18094 39923-39924 SO:0001031 denotes R
T18093 39894-39895 SO:0001030 denotes F
T18092 39886-39892 SO:0001023 denotes allele
T18091 39875-39880 PR:000013523 denotes Pygo1
T18090 39847-39848 SO:0001031 denotes R
T18089 39820-39821 SO:0001030 denotes F
T18088 39812-39818 SO:0001023 denotes allele
T18087 39805-39811 SO:0000359 denotes floxed
T18086 39793-39798 PR:000013524 denotes Pygo2
T18044 38358-38366 CHEBI:7507 denotes neomycin
T18043 38308-38314 SO:0000440 denotes vector
T18042 38300-38303 PR:P03870 denotes Flp
T18041 38243-38257 SO:0000346 denotes LoxP sequences
T18040 38208-38212 SO:0001215 denotes exon
T18039 38180-38197 _FRAGMENT denotes coding regions of
T18038 38158-38166 SO:0000357 denotes flanking
T18037 38130-38135 SO:0000704 denotes genes
T18036 38124-38129 PR:000013524 denotes Pygo2
T18035 38114-38119 PR:000013523 denotes Pygo1
T18034 38108-38113 PR:000013524 denotes Pygo2
T18033 38098-38103 PR:000013523 denotes Pygo1
T17042 37395-37402 NCBITaxon:40674 denotes mammals
T17062 38044-38049 SO:0000704 denotes genes
T17061 38026-38033 PR:Q9V9W8 denotes Pygopus
T17060 37983-37990 NCBITaxon:40674 denotes mammals
T17059 37974-37979 PR:000013524 denotes Pygo2
T17058 37968-37973 PR:000013523 denotes Pygo1
T17057 37902-37909 GO:0005634 denotes nuclear
T17056 37795-37823 GO:0005667 denotes transcription-factor complex
T17055 37785-37794 PR:000002198 denotes β-catenin
T17054 37774-37779 SO:0000704 denotes genes
T17053 37766-37773 PR:Q9V9W8 denotes Pygopus
T17052 37712-37717 SO:0000704 denotes genes
T17051 37697-37704 NCBITaxon:40674 denotes mammals
T17050 37636-37643 PR:Q9V9W8 denotes Pygopus
T17049 37603-37616 GO:0048513 denotes organogenesis
T17048 37593-37602 NCBITaxon:40674 denotes mammalian
T17047 37540-37553 GO:0016055 denotes Wnt signaling
T17046 37531-37536 SO:0000704 denotes genes
T17045 37524-37528 PR:000013523 denotes Pyg1
T17044 37480-37490 NCBITaxon:7215 denotes Drosophila
T17043 37439-37446 PR:Q9V9W8 denotes Pygopus
T15046 36422-36445 GO:0060070 denotes canonical Wnt signaling
T15045 36383-36389 UBERON:0002113 denotes kidney
T15044 36350-36360 GO:0010467 denotes expression
T15043 36317-36322 SO:0000704 denotes genes
T15042 36274-36292 GO:0001822 denotes kidney development
T15041 36274-36280 UBERON:0002113 denotes kidney
T15040 36195-36205 GO:0010467 denotes expression
T15039 36184-36189 SO:0000704 denotes genes
T15038 36168-36178 NCBITaxon:7215 denotes Drosophila
T15037 36111-36134 GO:0060070 denotes canonical Wnt signaling
T15036 36086-36093 NCBITaxon:40674 denotes mammals
T15035 36077-36082 SO:0000704 denotes genes
T15034 36069-36076 PR:Q9V9W8 denotes Pygopus
T15033 35911-35921 GO:0010467 denotes expression
T15032 35886-35891 SO:0000704 denotes genes
T15031 35821-35836 GO:0010467 denotes gene-expression
T15030 35821-35825 SO:0000704 denotes gene
T15029 35806-35813 UBERON:0002113 denotes kidneys
T14964 33597-33607 UBERON:0003104 denotes mesenchyme
T14963 33559-33581 UBERON:0003220 denotes metanephric mesenchyme
T14962 33538-33551 GO:0016055 denotes Wnt signaling
T14961 33423-33435 UBERON:0000084 denotes ureteric bud
T14960 33402-33415 GO:0016055 denotes Wnt signaling
T14959 33344-33356 UBERON:0000084 denotes ureteric bud
T14958 33344-33356 GO:0001658 denotes ureteric bud
T14957 33313-33339 _FRAGMENT denotes branching morphogenesis of
T14956 33286-33309 GO:0060070 denotes canonical Wnt signaling
T14955 33238-33246 UBERON:0000056 denotes ureteric
T14954 33196-33202 UBERON:0002113 denotes kidney
T14953 33166-33178 UBERON:0006364 denotes ureteric tip
T14952 33102-33115 GO:0016055 denotes Wnt signaling
T14951 33030-33035 PR:000013524 denotes Pygo2
T14950 33006-33012 UBERON:0002113 denotes kidney
T14949 32955-32967 UBERON:0000084 denotes ureteric bud
T14948 32924-32947 GO:0060070 denotes canonical Wnt signaling
T14947 32879-32888 SO:0000902 denotes transgene
T14946 32847-32865 GO:0001822 denotes kidney development
T14945 32847-32853 UBERON:0002113 denotes kidney
T14944 32768-32790 UBERON:0003220 denotes metanephric mesenchyme
T14943 32750-32760 GO:0010467 denotes expression
T14942 32745-32749 PR:000007928 denotes GDNF
T14941 32715-32732 UBERON:0006364 denotes ureteric bud tips
T14940 32690-32695 PR:000017438 denotes Wnt11
T14939 32658-32671 GO:0001822 denotes nephrogenesis
T14938 32609-32631 UBERON:0003220 denotes metanephric mesenchyme
T14937 32578-32582 PR:000017444 denotes Wnt4
T14936 32569-32574 PR:000017453 denotes Wnt9b
T14935 32536-32549 GO:0001822 denotes nephrogenesis
T14934 32502-32524 UBERON:0003220 denotes metanephric mesenchyme
T14933 32473-32485 UBERON:0000084 denotes ureteric bud
T14932 32452-32457 PR:000017453 denotes Wnt9b
T14931 32437-32450 GO:0001822 denotes nephrogenesis
T14930 32358-32371 GO:0016055 denotes Wnt signaling
T14929 32341-32347 UBERON:0002113 denotes kidney
T14928 32290-32297 SO:0001023 denotes alleles
T14927 32110-32114 SO:0000704 denotes gene
T14926 32104-32109 PR:000013524 denotes Pygo2
T14925 32022-32026 SO:0000704 denotes gene
T14924 32016-32021 PR:000013523 denotes Pygo1
T14923 31959-31966 SO:0000417 denotes domains
T14922 31895-31902 SO:0001023 denotes alleles
T14921 31882-31887 PR:000013524 denotes Pygo2
T14920 31876-31881 PR:000013523 denotes Pygo1
T14919 31841-31866 GO:0007444 denotes imaginal disc development
T14918 31841-31854 UBERON:0000939 denotes imaginal disc
T14917 31823-31836 GO:0009790 denotes embryogenesis
T14916 31792-31805 GO:0016055 denotes Wnt signaling
T14915 31752-31758 SO:0000417 denotes domain
T14914 31675-31681 SO:0001023 denotes allele
T14913 31651-31661 NCBITaxon:7215 denotes Drosophila
T14912 31589-31609 GO:0006338 denotes chromatin remodeling
T14911 31589-31598 GO:0000785 denotes chromatin
T14910 31489-31496 SO:0000417 denotes domains
T14909 31474-31483 CHEBI:27365 denotes zinc ions
T14908 31386-31392 SO:0000417 denotes domain
T14907 31364-31366 PR:000017435 denotes Wg
T14906 31344-31351 PR:Q9V9W8 denotes Pygopus
T14905 31309-31315 SO:0000417 denotes domain
T14904 31266-31276 NCBITaxon:7215 denotes Drosophila
T14903 31181-31188 SO:0001023 denotes alleles
T14902 31164-31171 PR:Q9V9W8 denotes Pygopus
T14901 31153-31158 SO:0000704 denotes genes
T14900 31147-31152 PR:000013524 denotes Pygo2
T14899 31137-31142 PR:000013523 denotes Pygo1
T14898 31090-31094 SO:0000704 denotes gene
T14897 31005-31015 GO:0010467 denotes expression
T14896 30936-30943 UBERON:0000479 denotes tissues
T14895 30902-30907 PR:000013524 denotes Pygo2
T14894 30896-30901 PR:000013523 denotes Pygo1
T14893 30770-30775 PR:000013523 denotes Pygo1
T14892 30724-30729 GO:0007567 denotes birth
T14891 30697-30702 PR:000013524 denotes Pygo2
T14890 30666-30671 PR:000013524 denotes Pygo2
T14889 30660-30665 PR:000013523 denotes Pygo1
T14888 30643-30648 PR:000013524 denotes Pygo2
T14887 30636-30641 PR:000013523 denotes Pygo1
T14886 30617-30621 NCBITaxon:10088 denotes mice
T14885 30571-30581 NCBITaxon:7215 denotes Drosophila
T14884 30510-30512 PR:000017435 denotes Wg
T14883 30431-30450 GO:0007507 denotes cardiac development
T14882 30431-30438 UBERON:0000948 denotes cardiac
T14881 30439-30450 GO:0007417 denotes development
T14880 30403-30425 _FRAGMENT denotes central nervous system
T14879 30403-30425 UBERON:0001017 denotes central nervous system
T14878 30382-30388 UBERON:0001045 denotes midgut
T14877 30362-30369 UBERON:0001002 denotes cuticle
T14876 30310-30320 NCBITaxon:7215 denotes Drosophila
T14875 30239-30252 GO:0016055 denotes Wnt signaling
T14874 30175-30189 UBERON:0000939 denotes imaginal discs
T14873 30171-30174 UBERON:0000970 denotes eye
T14872 30161-30165 UBERON:0000023 denotes wing
T14871 30156-30159 UBERON:0005895 denotes leg
T14870 30088-30101 GO:0016055 denotes Wnt signaling
T14869 30025-30048 GO:0060070 denotes canonical Wnt signaling
T14868 29999-30003 SO:0000704 denotes gene
T15028 35773-35778 SO:0000704 denotes genes
T15027 35756-35765 SO:0000167 denotes promoters
T15026 35685-35693 SO:0000167 denotes promoter
T15025 35641-35651 GO:0010467 denotes expression
T15024 35628-35636 GO:0065007 denotes monitors
T15023 35609-35618 SO:0000902 denotes transgene
T15022 35468-35491 GO:0060070 denotes canonical Wnt signaling
T15021 35433-35438 SO:0000704 denotes genes
T15020 35425-35432 PR:Q9V9W8 denotes Pygopus
T15019 35415-35424 NCBITaxon:40674 denotes mammalian
T15018 35277-35290 GO:0048513 denotes organogenesis
T15017 35254-35259 PR:000013524 denotes Pygo2
T15016 35248-35253 PR:000013523 denotes Pygo1
T15015 35178-35185 UBERON:0002113 denotes kidneys
T15014 35111-35117 UBERON:0000479 denotes tissue
T15013 35097-35104 UBERON:0000922 denotes embryos
T15012 35084-35089 PR:000013524 denotes Pygo2
T15011 35078-35083 PR:000013523 denotes Pygo1
T15010 35004-35027 GO:0060070 denotes canonical Wnt signaling
T15009 34982-34991 SO:0000902 denotes transgene
T15008 34945-34968 GO:0060070 denotes canonical Wnt signaling
T15007 34906-34911 SO:0000704 denotes genes
T15006 34900-34905 PR:000013524 denotes Pygo2
T15005 34894-34899 PR:000013523 denotes Pygo1
T15004 34882-34889 NCBITaxon:40674 denotes mammals
T15003 34848-34871 GO:0060070 denotes canonical Wnt signaling
T15002 34821-34825 SO:0000704 denotes gene
T15001 34813-34820 PR:Q9V9W8 denotes Pygopus
T15000 34797-34807 NCBITaxon:7215 denotes Drosophila
T14999 34785-34792 NCBITaxon:40674 denotes mammals
T14998 34770-34780 NCBITaxon:7215 denotes Drosophila
T14997 34745-34752 PR:Q9V9W8 denotes Pygopus
T14996 34627-34650 GO:0060070 denotes canonical Wnt signaling
T14995 34609-34622 GO:0001822 denotes nephrogenesis
T14994 34561-34583 UBERON:0003220 denotes metanephric mesenchyme
T14993 34541-34553 UBERON:0000084 denotes ureteric bud
T14992 34516-34521 PR:000017453 denotes Wnt9b
T14991 34459-34467 UBERON:0001285 denotes nephrons
T14990 34429-34451 UBERON:0003220 denotes metanephric mesenchyme
T14989 34390-34402 UBERON:0000084 denotes ureteric bud
T14988 34365-34375 UBERON:0003104 denotes mesenchyme
T14987 34299-34304 PR:000013523 denotes Pygo1
T14986 34281-34293 UBERON:0000084 denotes ureteric bud
T14985 34260-34273 GO:0016055 denotes Wnt signaling
T14984 34223-34228 PR:000013524 denotes Pygo2
T14983 34217-34222 PR:000013523 denotes Pygo1
T14982 34179-34189 UBERON:0003104 denotes mesenchyme
T14981 34155-34169 GO:0035860 denotes GDNF signaling
T14980 34155-34159 PR:000007928 denotes GDNF
T14979 34140-34150 UBERON:0003104 denotes mesenchyme
T14978 34120-34132 UBERON:0000084 denotes ureteric bud
T14977 34097-34110 GO:0016055 denotes Wnt signaling
T14965 33611-33623 UBERON:0000084 denotes ureteric bud
T11898 29378-29383 SO:0000704 denotes genes
T11897 29193-29198 SO:0000704 denotes genes
T11896 28504-28511 UBERON:0002113 denotes kidneys
T11895 28491-28496 PR:000013524 denotes Pygo2
T11894 28485-28490 PR:000013523 denotes Pygo1
T11893 28472-28477 SO:0000704 denotes genes
T11892 28451-28464 GO:0016055 denotes Wnt signaling
T11891 28420-28430 GO:0010467 denotes expression
T11890 28354-28361 UBERON:0002113 denotes kidneys
T11889 28343-28348 PR:000013524 denotes Pygo2
T11888 28337-28342 PR:000013523 denotes Pygo1
T11887 28296-28306 GO:0010467 denotes expression
T11886 28252-28257 PR:000017426 denotes Wisp1
T11885 28232-28241 PR:000005121 denotes cyclin D1
T11884 28217-28222 PR:000005121 denotes Ccnd1
T11883 28203-28213 GO:0010467 denotes expression
T11882 28174-28181 UBERON:0002113 denotes kidneys
T11881 28134-28144 GO:0010467 denotes expression
T11880 28097-28102 SO:0000704 denotes genes
T11879 27976-27981 PR:000013524 denotes Pygo2
T11878 27966-27971 PR:000013523 denotes Pygo1
T11877 27904-27911 UBERON:0002113 denotes kidneys
T11876 27888-27893 PR:000013524 denotes Pygo2
T11875 27879-27884 PR:000013523 denotes Pygo1
T11874 27829-27839 GO:0010467 denotes expression
T11873 27756-27779 GO:0001763 denotes branching morphogenesis
T11872 27747-27755 UBERON:0000056 denotes ureteric
T11871 27738-27746 GO:0065007 denotes regulate
T11870 27700-27713 UBERON:0006364 denotes ureteric tips
T11869 27673-27682 GO:0010467 denotes expressed
T11868 27636-27667 GO:0042752 denotes regulation of circadian rhythms
T11867 27587-27595 PR:000016340 denotes Timeless
T11866 27558-27580 UBERON:0004100 denotes collecting-duct system
T11865 27547-27553 UBERON:0000056 denotes ureter
T11864 27460-27465 PR:000013883 denotes renin
T11863 27421-27426 UBERON:0000178 denotes blood
T11862 27384-27389 PR:000013883 denotes renin
T11861 27361-27368 PR:000014394 denotes Renin 1
T11860 27332-27339 SO:0000853 denotes homolog
T11859 27324-27328 PR:000014395 denotes Ren2
T11858 27303-27308 UBERON:0000178 denotes blood
T11857 27289-27317 GO:0008217 denotes regulation of blood pressure
T11856 27266-27283 GO:0048771 denotes tissue remodeling
T11855 27266-27272 UBERON:0000479 denotes tissue
T11854 27189-27196 PR:000027795 denotes trypsin
T11853 27144-27148 PR:000009416 denotes Klk6
T11852 27135-27139 PR:000009415 denotes Klk5
T11851 27114-27122 PR:000016340 denotes Timeless
T11850 27093-27097 PR:000014395 denotes Ren2
T11849 27076-27080 PR:000009416 denotes Klk6
T11848 27059-27063 PR:000009415 denotes Klk5
T11847 27043-27049 UBERON:0002113 denotes kidney
T11846 27032-27037 PR:000013524 denotes Pygo2
T11845 27026-27031 PR:000013523 denotes Pygo1
T11844 27001-27006 SO:0000704 denotes genes
T11843 24926-24933 UBERON:0001285 denotes nephron
T11842 24899-24904 SO:0000704 denotes genes
T11841 24893-24898 PR:000013524 denotes Pygo2
T11840 24887-24892 PR:000013523 denotes Pygo1
T11839 24837-24842 UBERON:0007023 denotes adult
T11838 24843-24849 UBERON:0009773 denotes kidney
T11837 24822-24832 _FRAGMENT denotes tubules of
T11836 24805-24814 GO:0010467 denotes expressed
T11835 24779-24786 PR:000015966 denotes Slco1a4
T11834 24752-24765 CHEBI:25696 denotes organic anion
T11833 24734-24741 UBERON:0001285 denotes nephron
T11832 24712-24726 GO:0046323 denotes glucose uptake
T11831 24712-24719 CHEBI:17234 denotes glucose
T11830 24669-24674 UBERON:0002113 denotes renal
T11829 24649-24658 GO:0030849 denotes autosomal
T11817 24319-24324 PR:000013524 denotes Pygo2
T11816 24309-24314 PR:000013523 denotes Pygo1
T11815 24131-24136 SO:0000704 denotes genes
T11814 24070-24077 UBERON:0002113 denotes kidneys
T11813 24061-24066 PR:000013524 denotes Pygo2
T11812 24052-24057 PR:000013523 denotes Pygo1
T9006 23609-23615 UBERON:0002113 denotes kidney
T9005 23568-23590 UBERON:0003220 denotes metanephric mesenchyme
T9004 23537-23560 GO:0060070 denotes canonical Wnt signaling
T9003 23496-23505 SO:0000902 denotes transgene
T9002 23446-23456 GO:0010467 denotes expression
T9001 23391-23404 GO:0001822 denotes nephrogenesis
T9000 23356-23378 UBERON:0003220 denotes metanephric mesenchyme
T8999 23343-23347 CHEBI:48607 denotes LiCl
T8998 23306-23311 UBERON:0000062 denotes organ
T8997 23299-23305 UBERON:0002113 denotes kidney
T8996 23282-23295 GO:0001822 denotes nephrogenesis
T8995 23194-23217 GO:0060070 denotes canonical Wnt signaling
T8994 23171-23175 CHEBI:48607 denotes LiCl
T8993 23153-23169 CHEBI:48607 denotes lithium chloride
T8992 23127-23149 UBERON:0003220 denotes metanephric mesenchyme
T8991 23058-23080 UBERON:0003220 denotes metanephric mesenchyme
T8990 23027-23050 GO:0060070 denotes canonical Wnt signaling
T8989 22989-22998 SO:0000902 denotes transgene
T8988 22930-22952 UBERON:0003220 denotes metanephric mesenchyme
T8987 22909-22922 GO:0001822 denotes nephrogenesis
T8986 22884-22889 PR:000017453 denotes Wnt9b
T8985 22848-22871 GO:0060070 denotes canonical Wnt signaling
T8984 22819-22823 PR:000017435 denotes Wnt1
T8983 22805-22815 GO:0010467 denotes expression
T8982 22792-22804 UBERON:0000084 denotes ureteric bud
T8981 22755-22777 UBERON:0003220 denotes metanephric mesenchyme
T8980 22724-22747 GO:0060070 denotes canonical Wnt signaling
T8979 22632-22654 UBERON:0003220 denotes metanephric mesenchyme
T8978 22601-22624 GO:0060070 denotes canonical Wnt signaling
T8977 22478-22493 UBERON:0004199 denotes S-shaped bodies
T8976 22508-22517 UBERON:0000074 denotes glomeruli
T8975 22495-22502 UBERON:0009773 denotes tubules
T8974 22462-22467 _FRAGMENT denotes renal
T8973 22462-22476 UBERON:0004209 denotes renal vesicles
T8972 22411-22433 UBERON:0003220 denotes metanephric mesenchyme
T8971 22384-22406 UBERON:0003220 denotes metanephric mesenchyme
T8970 22355-22365 GO:0010467 denotes expression
T8969 22319-22323 NCBITaxon:10088 denotes mice
T8968 21699-21705 UBERON:0002113 denotes kidney
T8967 21678-21686 UBERON:0000056 denotes ureteric
T8966 21628-21651 GO:0060070 denotes canonical Wnt signaling
T8965 21619-21624 SO:0000704 denotes genes
T8964 21613-21618 PR:000013524 denotes Pygo2
T8963 21603-21608 PR:000013523 denotes Pygo1
T8943 20938-20943 PR:000013524 denotes Pygo2
T8942 20929-20934 PR:000013523 denotes Pygo1
T8941 20916-20921 PR:000013524 denotes Pygo2
T8940 20907-20912 PR:000013523 denotes Pygo1
T8939 20901-20905 SO:0000704 denotes gene
T8938 20895-20900 PR:000013524 denotes Pygo2
T8937 20863-20870 UBERON:0002113 denotes kidneys
T8936 20812-20821 SO:0000902 denotes transgene
T8935 20764-20769 PR:000013524 denotes Pygo2
T8934 20758-20763 PR:000013523 denotes Pygo1
T8933 20743-20748 PR:000013524 denotes Pygo2
T8932 20717-20727 GO:0010467 denotes expression
T8931 20627-20635 UBERON:0000056 denotes ureteric
T8930 20596-20619 GO:0060070 denotes canonical Wnt signaling
T8929 20588-20592 SO:0000704 denotes gene
T8928 20582-20587 PR:000013524 denotes Pygo2
T8927 20537-20544 UBERON:0002113 denotes kidneys
T8926 20503-20508 PR:000013524 denotes Pygo2
T8925 20494-20499 PR:000013523 denotes Pygo1
T8924 20460-20465 PR:000013524 denotes Pygo2
T8923 20451-20456 PR:000013523 denotes Pygo1
T8922 20423-20428 PR:000013524 denotes Pygo2
T8921 20414-20419 PR:000013523 denotes Pygo1
T8920 20322-20327 PR:000013524 denotes Pygo2
T8919 20302-20314 UBERON:0001224 denotes renal pelvis
T8918 20333-20339 UBERON:0001232 denotes kidney
T8917 20315-20317 _FRAGMENT denotes of
T8916 20281-20297 _FRAGMENT denotes collecting ducts
T8915 20253-20258 CHEBI:75055 denotes X-gal
T8914 20176-20181 PR:000013524 denotes Pygo2
T8913 20167-20172 PR:000013523 denotes Pygo1
T8912 20185-20191 UBERON:0001225 denotes kidney
T8911 20155-20164 _FRAGMENT denotes cortex of
T8910 20096-20102 UBERON:0002113 denotes kidney
T8909 20087-20092 PR:000013524 denotes Pygo2
T8908 20078-20083 PR:000013523 denotes Pygo1
T8907 20055-20063 UBERON:0000056 denotes ureteric
T8906 20024-20029 CHEBI:75055 denotes X-gal
T8905 20015-20023 UBERON:0001851 denotes Cortical
T8904 19993-19999 UBERON:0002113 denotes kidney
T8903 19962-19974 UBERON:0001224 denotes renal pelvis
T8902 19940-19948 UBERON:0000056 denotes ureteric
T8901 19931-19939 UBERON:0001851 denotes cortical
T8900 19900-19923 GO:0060070 denotes canonical Wnt signaling
T8899 19743-19753 GO:0010467 denotes expression
T8898 19706-19710 NCBITaxon:10088 denotes mice
T8897 19697-19702 PR:000013524 denotes Pygo2
T8896 19688-19693 PR:000013523 denotes Pygo1
T8895 19675-19680 PR:000013524 denotes Pygo2
T8894 19666-19671 PR:000013523 denotes Pygo1
T8893 19623-19644 UBERON:0003890 denotes paramesonephric ducts
T8892 19601-19606 CHEBI:75055 denotes X-gal
T8891 19527-19537 GO:0010467 denotes expression
T8890 19480-19484 NCBITaxon:10088 denotes mice
T8889 19471-19476 PR:000013524 denotes Pygo2
T8888 19461-19466 UBERON:0003890 denotes ducts
T8887 19433-19448 _FRAGMENT denotes paramesonephric
T8886 19415-19425 GO:0010467 denotes expression
T8885 19369-19374 SO:0000704 denotes genes
T8884 19363-19368 PR:000013524 denotes Pygo2
T8883 19353-19358 PR:000013523 denotes Pygo1
T8882 19321-19326 PR:000013524 denotes Pygo2
T8881 19297-19307 GO:0010467 denotes expression
T8880 19249-19254 SO:0000704 denotes genes
T8879 19243-19248 PR:000013524 denotes Pygo2
T8878 19233-19238 PR:000013523 denotes Pygo1
T8877 19175-19185 GO:0010467 denotes expression
T8876 19123-19127 SO:0000704 denotes gene
T8875 19117-19122 PR:000013523 denotes Pygo1
T8874 19069-19092 GO:0060070 denotes canonical Wnt signaling
T8873 19012-19022 GO:0010467 denotes expression
T8872 18978-18985 UBERON:0002113 denotes kidneys
T8871 18963-18968 PR:000013524 denotes Pygo2
T8870 18954-18959 PR:000013523 denotes Pygo1
T8869 18914-18922 UBERON:0000056 denotes ureteric
T8868 18892-18897 CHEBI:75055 denotes X-gal
T8867 18873-18877 SO:0000704 denotes gene
T8866 18867-18872 PR:000013524 denotes Pygo2
T8865 18832-18838 UBERON:0002113 denotes kidney
T8864 18775-18780 CHEBI:75055 denotes X-gal
T8863 18738-18747 SO:0000902 denotes transgene
T8862 18710-18716 UBERON:0002113 denotes kidney
T8861 18679-18689 GO:0010467 denotes expression
T8850 15845-15857 UBERON:0009201 denotes nephric duct
T8849 15814-15819 PR:000013524 denotes Pygo2
T8848 15808-15813 PR:000013523 denotes Pygo1
T8847 15779-15789 GO:0010467 denotes expression
T8846 15725-15737 UBERON:0009201 denotes nephric duct
T8845 15707-15717 GO:0010467 denotes expression
T6288 13117-13122 PR:000013524 denotes Pygo2
T6287 13111-13116 PR:000013523 denotes Pygo1
T6286 13071-13076 PR:000017438 denotes Wnt11
T6285 12971-12984 GO:0097617 denotes hybridization
T6284 12924-12931 UBERON:0002113 denotes kidneys
T6283 12904-12909 PR:000013524 denotes Pygo2
T6282 12898-12903 PR:000013523 denotes Pygo1
T6281 12885-12890 PR:000013524 denotes Pygo2
T6280 12862-12872 GO:0010467 denotes expression
T6279 12841-12846 SO:0000704 denotes genes
T6278 12813-12825 UBERON:0006364 denotes ureteric bud
T6277 12791-12798 _FRAGMENT denotes tips of
T6276 12813-12825 UBERON:0012238 denotes ureteric bud
T6275 12796-12798 _FRAGMENT denotes of
T6274 12766-12772 _FRAGMENT denotes stalks
T6273 12753-12758 PR:000017453 denotes Wnt9b
T6272 12726-12731 PR:000017438 denotes Wnt11
T6271 12696-12705 GO:0010467 denotes expressed
T6270 12687-12692 PR:000017449 denotes Wnt7b
T6269 12664-12669 SO:0000704 denotes genes
T6268 12640-12650 GO:0010467 denotes expression
T6267 12614-12627 GO:0097617 denotes hybridization
T5548 11478-11484 UBERON:0000362 denotes kidney
T5546 11417-11434 UBERON:0006364 denotes ureteric bud tips
T5545 11367-11375 UBERON:0001285 denotes nephrons
T5544 11353-11357 PR:000001447 denotes Cdh1
T5543 11338-11351 GO:0001822 denotes nephrogenesis
T5542 11287-11309 UBERON:0003220 denotes metanephric mesenchyme
T5541 11227-11240 UBERON:0000084 denotes ureteric buds
T5540 11185-11203 UBERON:0005107 denotes capping mesenchyme
T5539 11119-11121 UBERON:0000084 denotes re
T5538 11098-11101 UBERON:0000483 denotes ite
T5537 11097-11098 PR:000001447 denotes C
T5536 11093-11095 UBERON:0003220 denotes an
T5535 11089-11092 PR:000017459 denotes Wt1
T5534 10237-10249 UBERON:0000084 denotes ureteric bud
T5533 10171-10188 NCBITaxon:271171 denotes Dolichos biflorus
T5532 10158-10164 UBERON:0002113 denotes kidney
T5531 10131-10139 UBERON:0001285 denotes nephrons
T5530 10106-10118 UBERON:0000084 denotes ureteric bud
T5529 10059-10069 UBERON:0000483 denotes epithelial
T5528 10018-10028 PR:000001447 denotes E-cadherin
T5527 9998-10002 PR:000001447 denotes Cdh1
T5526 9984-9994 GO:0042571 denotes Antibodies
T5525 9976-9982 UBERON:0007688 denotes anlage
T5524 9965-9975 UBERON:0000074 denotes glomerular
T5523 9946-9951 _FRAGMENT denotes renal
T5522 9946-9960 UBERON:0004209 denotes renal vesicles
T4593 8864-8870 UBERON:0002113 denotes kidney
T4592 8864-8870 CL:1000497 denotes kidney
T4591 8840-8848 _FRAGMENT denotes cells of
T4590 8791-8798 GO:0005634 denotes nuclear
T4589 8760-8773 CL:0000499 denotes stromal cells
T4588 8760-8767 UBERON:0003891 denotes stromal
T4587 8741-8746 PR:000013524 denotes Pygo2
T4586 8708-8713 PR:000013523 denotes Pygo1
T4585 8694-8704 GO:0010467 denotes expression
T4584 8661-8674 CL:0000499 denotes stromal cells
T4583 8661-8668 UBERON:0003891 denotes stromal
T4582 8637-8655 UBERON:0005107 denotes capping mesenchyme
T4581 8623-8635 UBERON:0000084 denotes ureteric bud
T4580 8575-8582 GO:0005634 denotes nuclear
T4579 8556-8565 GO:0010467 denotes expressed
T4578 8538-8543 SO:0000704 denotes genes
T4577 8525-8531 UBERON:0002113 denotes kidney
T4576 8501-8506 SO:0000704 denotes genes
T4575 8495-8500 PR:000013524 denotes Pygo2
T4574 8485-8490 PR:000013523 denotes Pygo1
T4573 8458-8468 GO:0010467 denotes expression
T4572 8322-8327 PR:000013523 denotes Pygo1
T4571 8308-8318 GO:0010467 denotes expression
T4570 8253-8266 GO:0097617 denotes hybridization
T4569 8238-8244 UBERON:0002113 denotes kidney
T4568 8214-8219 PR:000013524 denotes Pygo2
T4567 8204-8209 PR:000013523 denotes Pygo1
T4566 8190-8200 GO:0010467 denotes Expression
T828 2217-2224 NCBITaxon:40674 denotes mammals
T829 2229-2239 NCBITaxon:7215 denotes Drosophila
T830 2244-2251 NCBITaxon:40674 denotes mammals
T831 2257-2262 PR:000013523 denotes Pygo1
T832 2263-2268 PR:000013524 denotes Pygo2
T833 2269-2274 SO:0000704 denotes genes
T757 42-51 NCBITaxon:40674 denotes mammalian
T758 52-58 UBERON:0002113 denotes kidney
T759 52-70 GO:0001822 denotes kidney development
T760 96-103 PR:Q9V9W8 denotes pygopus
T761 104-108 SO:0000704 denotes gene
T762 112-122 NCBITaxon:7215 denotes Drosophila
T763 161-170 PR:P18824 denotes Armadillo
T764 172-181 PR:000002198 denotes β-catenin
T765 183-211 GO:0005667 denotes transcription factor complex
T766 215-238 GO:0060070 denotes canonical Wnt signaling
T767 278-285 PR:Q9V9W8 denotes Pygopus
T768 295-318 GO:0060070 denotes canonical Wnt signaling
T769 322-328 UBERON:0002113 denotes kidney
T770 322-340 GO:0001822 denotes kidney development
T771 382-391 NCBITaxon:40674 denotes mammalian
T772 392-401 SO:0000855 denotes orthologs
T773 403-408 PR:000013523 denotes Pygo1
T774 413-418 PR:000013524 denotes Pygo2
T775 507-513 SO:0000417 denotes domain
T776 563-568 PR:000013524 denotes Pygo2
T777 610-614 GO:0016265 denotes died
T778 629-634 GO:0007567 denotes birth
T779 706-712 UBERON:0002113 denotes kidney
T780 706-724 GO:0001822 denotes kidney development
T781 774-779 PR:000013523 denotes Pygo1
T782 883-888 PR:000013523 denotes Pygo1
T783 889-894 PR:000013524 denotes Pygo2
T784 976-985 SO:0000902 denotes transgene
T785 998-1021 GO:0060070 denotes canonical Wnt signaling
T786 1047-1057 GO:0010467 denotes expression
T787 1061-1066 PR:000013523 denotes Pygo1
T788 1070-1075 PR:000013524 denotes Pygo2
T789 1093-1099 UBERON:0000479 denotes tissue
T790 1148-1153 PR:000013523 denotes Pygo1
T791 1158-1163 PR:000013524 denotes Pygo2
T792 1164-1169 SO:0000704 denotes genes
T793 1193-1203 GO:0010467 denotes expression
T794 1222-1228 UBERON:0002113 denotes kidney
T795 1256-1263 UBERON:0003891 denotes stromal
T796 1256-1268 CL:0000499 denotes stromal cell
T797 1321-1328 UBERON:0002113 denotes kidneys
T798 1360-1372 UBERON:0000084 denotes ureteric bud
T799 1377-1399 UBERON:0003220 denotes metanephric mesenchyme
T800 1422-1448 _FRAGMENT denotes Branching morphogenesis of
T801 1453-1465 GO:0001658 denotes ureteric bud
T802 1453-1465 UBERON:0000084 denotes ureteric bud
T803 1579-1585 UBERON:0002113 denotes kidney
T804 1648-1658 UBERON:0003104 denotes mesenchyme
T805 1671-1683 UBERON:0000084 denotes ureteric bud
T806 1685-1692 UBERON:0001285 denotes Nephron
T807 1685-1702 GO:0072006 denotes Nephron formation
T808 1768-1778 GO:0010467 denotes expression
T809 1790-1795 SO:0000704 denotes genes
T810 1807-1813 PR:000006067 denotes Cxcl13
T811 1815-1821 PR:000015169 denotes Slc5a2
T812 1823-1827 PR:000009415 denotes Klk5
T813 1829-1833 PR:000014395 denotes Ren2
T814 1838-1846 PR:000016340 denotes Timeless
T815 1889-1895 UBERON:0002113 denotes kidney
T816 1889-1907 GO:0001822 denotes kidney development
T817 1925-1934 NCBITaxon:40674 denotes mammalian
T818 1935-1942 PR:Q9V9W8 denotes Pygopus
T819 1943-1948 SO:0000704 denotes genes
T820 1973-1999 _FRAGMENT denotes branching morphogenesis of
T821 2004-2016 GO:0001658 denotes ureteric bud
T822 2004-2016 UBERON:0000084 denotes ureteric bud
T823 2024-2030 UBERON:0002113 denotes kidney
T824 2024-2042 GO:0001822 denotes kidney development
T825 2104-2110 UBERON:0002113 denotes kidney
T826 2129-2142 UBERON:0000467 denotes organ systems
T827 2192-2199 PR:Q9V9W8 denotes Pygopus
T834 2307-2330 GO:0060070 denotes canonical Wnt signaling
T835 2350-2357 UBERON:0000467 denotes systems
T2429 2460-2473 GO:0016055 denotes Wnt signaling
T2430 2521-2527 UBERON:0002113 denotes kidney
T2431 2521-2539 GO:0001822 denotes kidney development
T2432 2583-2595 UBERON:0000084 denotes ureteric bud
T2433 2600-2622 UBERON:0003220 denotes metanephric mesenchyme
T2434 2629-2642 GO:0001822 denotes nephrogenesis
T2435 2652-2664 UBERON:0000084 denotes ureteric bud
T2436 2677-2682 PR:000017453 denotes Wnt9b
T2437 2724-2734 UBERON:0003104 denotes mesenchyme
T2438 2743-2751 UBERON:0001285 denotes nephrons
T2439 2757-2761 PR:000017444 denotes Wnt4
T2440 2785-2807 UBERON:0003220 denotes metanephric mesenchyme
T2441 2833-2846 GO:0001822 denotes nephrogenesis
T2442 2865-2870 PR:000017438 denotes Wnt11
T2443 2872-2880 GO:0046903 denotes secreted
T2444 2888-2905 UBERON:0006364 denotes ureteric bud tips
T2445 2958-2968 CL:0000125 denotes glial cell
T2446 2958-3001 PR:000007928 denotes glial cell line-derived neurotrophic factor
T2447 3003-3007 PR:000007928 denotes GDNF
T2448 3009-3019 GO:0010467 denotes expression
T2449 3027-3049 UBERON:0003220 denotes metanephric mesenchyme
T2450 3068-3073 PR:000017453 denotes Wnt9b
T2451 3077-3081 PR:000017444 denotes Wnt4
T2452 3112-3119 UBERON:0001285 denotes nephron
T2453 3112-3129 GO:0072006 denotes nephron formation
T2454 3137-3142 PR:000017438 denotes Wnt11
T2455 3183-3190 UBERON:0001285 denotes nephron
T2456 3230-3234 PR:000017444 denotes Wnt4
T2457 3239-3244 PR:000017438 denotes Wnt11
T2458 3373-3378 PR:000017453 denotes Wnt9b
T2459 3389-3412 GO:0060070 denotes canonical Wnt signaling
T2460 3420-3426 UBERON:0002113 denotes kidney
T2461 3432-3439 SO:0000704 denotes Genetic
T2462 3451-3461 NCBITaxon:7215 denotes Drosophila
T2463 3482-3489 PR:Q9V9W8 denotes Pygopus
T2464 3497-3501 SO:0000704 denotes gene
T2465 3529-3552 GO:0060070 denotes canonical Wnt signaling
T2466 3570-3573 PR:Q961D9 denotes Lgs
T2467 3588-3597 PR:000002198 denotes β-catenin
T2468 3609-3621 _FRAGMENT denotes formation of
T2469 3652-3659 GO:0065003 denotes complex
T2470 3652-3659 GO:0032991 denotes complex
T2471 3697-3706 PR:000002198 denotes β-catenin
T2472 3714-3721 GO:0005634 denotes nucleus
T2473 3728-3731 PR:Q961D9 denotes Lgs
T2474 3750-3759 PR:P18824 denotes armadillo
T2475 3771-3780 PR:000002198 denotes β-catenin
T2476 3808-3811 PR:Q961D9 denotes Lgs
T2477 3872-3878 SO:0000417 denotes domain
T2478 4000-4003 PR:Q961D9 denotes Lgs
T2479 4037-4044 GO:0005634 denotes nuclear
T2480 4037-4064 SO:0001528 denotes nuclear localization signal
T2481 4066-4069 SO:0001528 denotes NLS
T2482 4108-4114 SO:0000417 denotes domain
T2483 4154-4161 GO:0005634 denotes nuclear
T2484 4154-4173 GO:0051170 denotes nuclear importation
T2485 4177-4186 PR:000002198 denotes β-catenin
T2486 4231-4238 PR:Q9V9W8 denotes pygopus
T2487 4275-4279 SO:0000704 denotes gene
T2488 4315-4338 GO:0060070 denotes canonical Wnt signaling
T2489 4346-4356 NCBITaxon:7215 denotes Drosophila
T2490 4378-4387 NCBITaxon:40674 denotes mammalian
T2491 4388-4394 SO:0001026 denotes genome
T2492 4422-4431 SO:0000855 denotes orthologs
T2493 4435-4445 NCBITaxon:7215 denotes Drosophila
T2494 4452-4457 PR:000013523 denotes Pygo1
T2495 4462-4467 PR:000013524 denotes Pygo2
T2496 4529-4534 PR:000013523 denotes Pygo1
T2497 4539-4544 PR:000013524 denotes Pygo2
T2498 4632-4637 SO:0000704 denotes genes
T2499 4641-4664 GO:0060070 denotes canonical Wnt signaling
T2500 4672-4678 UBERON:0002113 denotes kidney
T2501 4672-4690 GO:0001822 denotes kidney development
T2502 4731-4738 UBERON:0000922 denotes embryos
T2503 4779-4802 GO:0060070 denotes canonical Wnt signaling
T2504 4831-4840 SO:0000902 denotes transgene
T2505 4841-4851 GO:0010467 denotes expression
T2506 4922-4927 GO:0007567 denotes birth
T2507 4961-4974 UBERON:0000467 denotes organ systems
T2508 5015-5021 UBERON:0002113 denotes kidney
T2509 5044-5070 _FRAGMENT denotes branching morphogenesis of
T2510 5075-5087 GO:0001658 denotes ureteric bud
T2511 5075-5087 UBERON:0000084 denotes ureteric bud
T2512 5128-5138 UBERON:0003104 denotes mesenchyme
T2513 5155-5167 UBERON:0000084 denotes ureteric bud
T2514 5191-5198 UBERON:0001285 denotes nephron
T2515 5191-5208 GO:0072006 denotes nephron formation
T2516 5263-5276 GO:0097617 denotes hybridization
T2517 5336-5343 NCBITaxon:40674 denotes mammals
T2518 5352-5362 NCBITaxon:7215 denotes Drosophila
T2519 5364-5371 PR:Q9V9W8 denotes Pygopus
T2520 5381-5404 GO:0060070 denotes canonical Wnt signaling
T2521 5452-5465 UBERON:0000467 denotes organ systems
T3444 5477-5482 PR:000013523 denotes Pygo1
T3445 5487-5492 PR:000013524 denotes Pygo2
T3446 5533-5538 PR:000013523 denotes Pygo1
T3447 5543-5548 PR:000013524 denotes Pygo2
T3448 5549-5554 SO:0000704 denotes genes
T3449 5568-5582 SO:0000346 denotes LoxP sequences
T3450 5586-5591 SO:0000357 denotes flank
T3451 5634-5641 SO:0000417 denotes domains
T3452 5666-5670 NCBITaxon:10088 denotes mice
T3453 5676-5681 GO:0007618 denotes mated
T3454 5698-5701 NCBITaxon:10358 denotes CMV
T3455 5706-5710 NCBITaxon:10088 denotes mice
T3456 5734-5738 SO:0000346 denotes LoxP
T3457 5783-5790 SO:0001023 denotes alleles
T3458 5894-5899 SO:0000704 denotes genes
T3459 5938-5943 PR:000013523 denotes Pygo1
T3460 5975-5980 PR:000013524 denotes Pygo2
T3461 6002-6012 NCBITaxon:7215 denotes Drosophila
T3462 6072-6078 SO:0000417 denotes domain
T3463 6110-6123 GO:0016055 denotes Wnt signaling
T4018 6130-6135 PR:000013523 denotes Pygo1
T4019 6140-6145 PR:000013524 denotes Pygo2
T4020 6164-6169 PR:000013523 denotes Pygo1
T4021 6186-6190 NCBITaxon:10088 denotes mice
T4022 6305-6312 PR:Q9V9W8 denotes pygopus
T4023 6313-6317 SO:0000704 denotes gene
T4024 6321-6334 GO:0016055 denotes Wnt signaling
T4025 6338-6348 NCBITaxon:7215 denotes Drosophila
T4026 6367-6377 GO:0010467 denotes expression
T4027 6404-6409 NCBITaxon:10088 denotes mouse
T4028 6410-6415 PR:000013523 denotes Pygo1
T4029 6416-6420 SO:0000704 denotes gene
T4030 6442-6447 UBERON:0000955 denotes brain
T4031 6449-6454 UBERON:0002101 denotes limbs
T4032 6456-6462 UBERON:0002113 denotes kidney
T4033 6467-6483 UBERON:0002539 denotes branchial arches
T4034 6555-6560 PR:000013524 denotes Pygo2
T4035 6577-6581 NCBITaxon:10088 denotes mice
T4036 6594-6599 GO:0007567 denotes birth
T4037 6627-6631 GO:0016265 denotes died
T4038 6656-6659 UBERON:0001555 denotes gut
T4039 6661-6666 UBERON:0000948 denotes heart
T4040 6671-6676 UBERON:0002101 denotes limbs
T4041 6766-6779 GO:0016055 denotes Wnt signaling
T4042 6785-6790 PR:000013524 denotes Pygo2
T4043 6858-6864 UBERON:0002113 denotes kidney
T4044 6980-6985 PR:000013523 denotes Pygo1
T4045 6990-6995 PR:000013524 denotes Pygo2
T4046 6996-7000 NCBITaxon:10088 denotes mice
T4047 7043-7048 PR:000013524 denotes Pygo2
T4048 7201-7206 PR:000013524 denotes Pygo2
T4049 7289-7294 PR:000013523 denotes Pygo1
T5568 12585-12592 UBERON:0000922 denotes embryos
T5567 12576-12581 PR:000013524 denotes Pygo2
T5566 12563-12568 PR:000013524 denotes Pygo2
T5565 12521-12537 UBERON:0006364 denotes ureteric bud-tip
T5564 12475-12480 PR:000013524 denotes Pygo2
T5563 12386-12403 UBERON:0006364 denotes ureteric bud tips
T5562 12320-12327 UBERON:0002113 denotes kidneys
T5561 12289-12294 PR:000013524 denotes Pygo2
T5560 12283-12288 PR:000013523 denotes Pygo1
T5559 12247-12253 SO:0001023 denotes allele
T5558 12241-12246 PR:000013524 denotes Pygo2
T5557 12143-12150 UBERON:0002113 denotes kidneys
T5556 12132-12137 PR:000013524 denotes Pygo2
T5555 12126-12131 PR:000013523 denotes Pygo1
T5554 12100-12117 UBERON:0006364 denotes ureteric bud tips
T5553 12081-12082 UBERON:0002113 denotes s
T5552 11590-11605 UBERON:0004199 denotes S-shaped bodies
T5551 11565-11584 UBERON:0004198 denotes comma-shaped bodies
T5550 11549-11563 UBERON:0004209 denotes renal vesicles
T5549 11524-11537 GO:0001822 denotes nephrogenesis
T5547 11463-11473 _FRAGMENT denotes medulla of
T11811 23992-23997 SO:0000704 denotes genes
T11810 23966-23976 GO:0010467 denotes expression
T11809 23917-23930 GO:0016055 denotes Wnt signaling
T11808 23905-23913 SO:0000167 denotes promoter
T11807 23876-23884 GO:0065007 denotes monitors
T11806 23857-23866 SO:0000902 denotes transgene
T11805 23812-23827 GO:0010467 denotes gene expression
T11804 23812-23816 SO:0000704 denotes gene
T11803 23751-23758 UBERON:0002113 denotes kidneys
T11802 23738-23743 PR:000013524 denotes Pygo2
T11801 23732-23737 PR:000013523 denotes Pygo1
T11800 23709-23724 GO:0010467 denotes gene expression
T11799 23709-23713 SO:0000704 denotes gene
T11798 23658-23665 UBERON:0002113 denotes kidneys
T11797 23647-23652 PR:000013524 denotes Pygo2
T11796 23641-23646 PR:000013523 denotes Pygo1
T14867 29991-29998 PR:Q9V9W8 denotes Pygopus
T14866 29975-29985 NCBITaxon:7215 denotes Drosophila
T18076 39609-39613 NCBITaxon:10088 denotes mice
T17041 37367-37390 GO:0060070 denotes canonical Wnt signaling
T17040 37285-37289 NCBITaxon:10088 denotes mice
T17039 37270-37275 PR:000013524 denotes Pygo2
T17038 37264-37269 PR:000013523 denotes Pygo1
T17037 37246-37256 GO:0010467 denotes expression
T17036 37227-37236 SO:0000902 denotes transgene
T17035 37150-37163 GO:0016055 denotes Wnt signaling
T17034 37108-37115 UBERON:0000467 denotes systems
T17033 37078-37083 SO:0000704 denotes genes
T17032 37070-37077 PR:Q9V9W8 denotes Pygopus
T17031 37060-37069 NCBITaxon:40674 denotes mammalian
T17030 37018-37031 GO:0001822 denotes nephrogenesis
T17029 36991-37014 GO:0060070 denotes canonical Wnt signaling
T17028 36957-36967 NCBITaxon:7215 denotes Drosophila
T17027 36930-36953 GO:0060070 denotes canonical Wnt signaling
T17026 36922-36926 SO:0000704 denotes gene
T17025 36914-36921 PR:Q9V9W8 denotes Pygopus
T17024 36827-36832 PR:000013524 denotes Pygo2
T17023 36821-36826 PR:000013523 denotes Pygo1
T17022 36764-36781 GO:0072006 denotes nephron formation
T17021 36764-36771 UBERON:0001285 denotes nephron
T17020 36735-36748 UBERON:0000084 denotes ureteric buds
T17019 36698-36720 UBERON:0003220 denotes metanephric mesenchyme
T17018 36646-36651 PR:000013524 denotes Pygo2
T17017 36553-36565 UBERON:0000084 denotes ureteric bud
T17016 36553-36565 GO:0001658 denotes ureteric bud
T17015 36522-36548 _FRAGMENT denotes branching morphogenesis of
T17014 36494-36498 SO:0000704 denotes gene
T17013 36488-36493 PR:000013524 denotes Pygo2
T17012 36478-36487 NCBITaxon:40674 denotes mammalian
T18075 39602-39608 SO:0000359 denotes floxed
T18074 39582-39588 GO:0007618 denotes mating
T18073 39558-39563 PR:000013524 denotes Pygo2
T18072 39548-39553 PR:000013523 denotes Pygo1
T18071 39532-39539 SO:0001023 denotes alleles
T18070 39438-39442 NCBITaxon:10088 denotes mice
T18069 39415-39420 GO:0007618 denotes mated
T18068 39336-39346 UBERON:0000358 denotes blastocyst
T18085 39766-39767 SO:0001031 denotes R
T18084 39757-39764 SO:0001031 denotes reverse
T18083 39729-39730 SO:0001030 denotes F
T18082 39720-39727 SO:0001030 denotes forward
T18081 39712-39718 SO:0001023 denotes allele
T18080 39701-39706 PR:000013524 denotes Pygo2
T18079 39663-39670 SO:0000112 denotes primers
T18078 39631-39635 NCBITaxon:10088 denotes mice
T18077 39623-39626 NCBITaxon:10358 denotes CMV
T18067 39310-39318 CL:0002322 denotes ES cells
T18066 39277-39285 CL:0002322 denotes ES cells
T18065 39165-39169 SO:0000147 denotes exon
T18064 39019-39026 SO:0001026 denotes genomic
T18063 39008-39013 PR:000013524 denotes Pygo2
T18062 38976-38980 SO:0001031 denotes back
T18061 38940-38947 SO:0001030 denotes forward
T18060 38907-38911 SO:0001031 denotes back
T18059 38902-38906 SO:0000147 denotes exon
T18058 38871-38878 SO:0001030 denotes forward
T18057 38866-38870 SO:0000147 denotes exon
T18056 38837-38841 SO:0001031 denotes back
T18055 38799-38806 SO:0001030 denotes forward
T18054 38759-38766 SO:0001026 denotes genomic
T18053 38748-38753 PR:000013523 denotes Pygo1
T18052 38666-38673 CL:0002322 denotes ES cell
T18051 38600-38607 SO:0001026 denotes genomic
T18050 38554-38568 SO:0000346 denotes LoxP sequences
T18049 38543-38550 SO:0000357 denotes flanked
T18048 38426-38443 SO:0000061 denotes restriction sites
T18047 38394-38407 SO:0000350 denotes FRT sequences
T18046 38383-38390 SO:0000357 denotes flanked
T18045 38378-38382 SO:0000704 denotes gene
T20008 42738-42744 UBERON:0000922 denotes embryo
T20007 42705-42710 PR:000013523 denotes Pygo1
T20006 42662-42672 GO:0042571 denotes antibodies
T20005 42628-42636 GO:0042571 denotes antibody
T20004 42567-42576 GO:0042571 denotes antibodes
T20003 42518-42524 PR:Q9D0P5 denotes mPygo1
T20002 42514-42517 PR:000022850 denotes GST
T20001 42504-42510 PR:Q9BRQ0 denotes hPygo2
T20000 42500-42503 PR:000022850 denotes GST
T19999 42453-42456 PR:000022850 denotes GST
T19998 42419-42423 UBERON:0001977 denotes sera
T19997 42408-42414 PR:Q9D0P5 denotes mPygo1
T20596 43404-43409 PR:000013524 denotes Pygo2
T20595 43393-43398 PR:000013523 denotes Pygo1
T20594 43371-43376 PR:000013524 denotes Pygo2
T20593 43360-43365 PR:000013523 denotes Pygo1
T20590 43097-43107 GO:0010467 denotes expression
T21151 43518-43523 PR:000013523 denotes Pygo1
T21150 43484-43491 UBERON:0002113 denotes kidneys
T22246 7346-7351 PR:000013523 denotes Pygo1
T22247 7352-7357 PR:000013524 denotes Pygo2
T22248 7365-7372 UBERON:0000922 denotes embryos
T22249 7384-7389 PR:000013523 denotes Pygo1
T22250 7393-7398 PR:000013524 denotes Pygo2
T22251 7402-7409 UBERON:0000922 denotes embryos
T22252 7435-7440 PR:000013524 denotes Pygo2
T22253 7441-7447 SO:0001023 denotes allele
T22254 7498-7503 PR:000013523 denotes Pygo1
T22255 7507-7512 PR:000013524 denotes Pygo2
T22256 7516-7523 UBERON:0000922 denotes embryos
T22257 7543-7546 UBERON:0000970 denotes eye
T22258 7603-7612 CHEBI:26130 denotes pigmented
T22259 7613-7619 UBERON:0000966 denotes retina
T22260 7656-7661 PR:000013523 denotes Pygo1
T22261 7662-7667 PR:000013524 denotes Pygo2
T22262 7673-7680 UBERON:0000922 denotes embryos
T23082 10998-11010 UBERON:0000084 denotes ureteric bud
T23081 10971-10981 UBERON:0003104 denotes mesenchyme
T23080 10912-10917 PR:000013523 denotes Pygo1
T23079 10867-10884 UBERON:0006364 denotes ureteric bud tips
T23078 10804-10811 UBERON:0002113 denotes kidneys
T23077 10793-10798 PR:000013524 denotes Pygo2
T23076 10787-10792 PR:000013523 denotes Pygo1
T23075 10737-10750 UBERON:0006364 denotes ureteric tips
T23074 10638-10646 UBERON:0000056 denotes ureteric
T23073 10592-10601 UBERON:0000483 denotes epithelia
T23072 10566-10570 PR:000001447 denotes Cdh1
T23071 10522-10544 UBERON:0003220 denotes metanephric mesenchyme
T23070 10494-10503 GO:0010467 denotes expressed
T23069 10484-10487 PR:000017459 denotes Wt1
T23068 10467-10473 PR:000005505 denotes Cited1
T23067 10446-10456 GO:0042571 denotes antibodies
T23066 10397-10404 UBERON:0002113 denotes kidneys
T23065 10378-10385 UBERON:0002113 denotes kidneys
T23064 10356-10361 PR:000013524 denotes Pygo2
T23063 10347-10352 PR:000013523 denotes Pygo1
T23062 10331-10338 UBERON:0002113 denotes kidneys
T23061 10312-10317 PR:000013524 denotes Pygo2
T23060 10306-10311 PR:000013523 denotes Pygo1
T25726 17563-17571 UBERON:0000056 denotes ureteric
T25725 17549-17559 GO:0010467 denotes expression
T25724 17484-17489 PR:000013524 denotes Pygo2
T25723 17475-17480 PR:000013523 denotes Pygo1
T25722 17464-17470 UBERON:0002113 denotes kidney
T25721 17446-17456 GO:0010467 denotes expression
T25720 17432-17440 UBERON:0000056 denotes ureteric
T25719 17364-17384 UBERON:0003890 denotes paramesonephric duct
T25718 17346-17356 GO:0010467 denotes expression
T25717 17297-17302 PR:000013524 denotes Pygo2
T25716 17288-17293 PR:000013523 denotes Pygo1
T25715 17266-17274 UBERON:0000056 denotes ureteric
T25714 17223-17243 UBERON:0003890 denotes paramesonephric duct
T25713 17205-17215 GO:0010467 denotes expression
T25712 17181-17186 PR:000013524 denotes Pygo2
T25711 17172-17177 PR:000013523 denotes Pygo1
T25710 17146-17154 UBERON:0000056 denotes ureteric
T25709 17078-17083 PR:000013524 denotes Pygo2
T25708 17069-17074 PR:000013523 denotes Pygo1
T25707 17057-17063 UBERON:0000056 denotes ureter
T25706 17038-17046 UBERON:0000056 denotes ureteric
T25705 17023-17036 UBERON:0006364 denotes ureteric tips
T25704 17001-17007 UBERON:0002113 denotes kidney
T25703 16962-16970 UBERON:0000056 denotes ureteric
T25702 16914-16919 PR:000013524 denotes Pygo2
T25701 16905-16910 PR:000013523 denotes Pygo1
T25700 16822-16831 SO:0000902 denotes transgene
T25699 16795-16801 UBERON:0000922 denotes embryo
T25698 16764-16774 UBERON:0004122 denotes urogenital
T25697 16744-16749 CHEBI:75055 denotes X-gal
T25696 16693-16705 UBERON:0000084 denotes ureteric bud
T25695 16661-16673 UBERON:0009201 denotes nephric duct
T25694 16638-16648 GO:0010467 denotes expression
T25675 16122-16127 CHEBI:75055 denotes X-Gal
T27416 7792-7797 PR:000013523 denotes Pygo1
T27646 29604-29611 UBERON:0002113 denotes kidneys
T27645 29566-29573 UBERON:0002113 denotes kidneys
T27644 29555-29560 PR:000013524 denotes Pygo2
T27643 29549-29554 PR:000013523 denotes Pygo1
T27642 29512-29527 GO:0010467 denotes gene expression
T26877 22203-22210 SO:0001023 denotes alleles
T26876 22197-22202 PR:000013523 denotes Pygo1
T26875 22141-22151 GO:0010467 denotes expression
T26874 22108-22113 PR:000013524 denotes Pygo2
T26873 22068-22078 GO:0010467 denotes expression
T26872 22024-22029 PR:000013523 denotes Pygo1
T26871 22003-22008 PR:000013524 denotes Pygo2
T27641 29512-29516 SO:0000704 denotes gene
T27252 29060-29070 GO:0010467 denotes expression
T27251 28995-29000 PR:000013524 denotes Pygo2
T27250 28985-28990 PR:000013523 denotes Pygo1
T27249 28930-28940 GO:0010467 denotes expression
T27248 28883-28893 GO:0010467 denotes expression
T27247 28868-28873 SO:0000704 denotes genes
T27246 28794-28798 SO:0000704 denotes gene
T27245 28710-28717 UBERON:0002113 denotes kidneys
T27244 28682-28687 PR:000013523 denotes Pygo1
T27243 28609-28615 UBERON:0002113 denotes kidney
T27242 28598-28603 PR:000013524 denotes Pygo2
T27414 7732-7737 PR:000013524 denotes Pygo2
T27415 7779-7786 UBERON:0000922 denotes embryos
T27480 11714-11719 PR:000013523 denotes Pygo1
T27479 11699-11706 UBERON:0002113 denotes kidneys
T27478 11653-11658 PR:000013524 denotes Pygo2
T27561 25000-25009 GO:0010467 denotes expressed
T27560 24979-24984 SO:0000704 denotes Genes
T8809 13727-13750 GO:0060070 denotes canonical Wnt signaling
T8808 13705-13714 SO:0000902 denotes transgene
T8807 13688-13692 NCBITaxon:10088 denotes mice
T8806 13675-13680 PR:000013524 denotes Pygo2
T8805 13669-13674 PR:000013523 denotes Pygo1
T8804 13642-13665 GO:0060070 denotes canonical Wnt signaling
T8843 15645-15650 PR:000013524 denotes Pygo2
T8842 15639-15644 PR:000013523 denotes Pygo1
T8841 15624-15629 PR:000013524 denotes Pygo2
T8840 15605-15617 UBERON:0009201 denotes nephric duct
T8839 15574-15597 GO:0060070 denotes canonical Wnt signaling
T8838 15553-15557 SO:0000704 denotes gene
T8837 15547-15552 PR:000013524 denotes Pygo2
T8836 15481-15498 UBERON:0004122 denotes urogenital system
T8835 15442-15447 GO:0010467 denotes ssion
T8834 15433-15434 GO:0060070 denotes t
T8833 15430-15432 GO:0010467 denotes po
T8832 15428-15430 GO:0010467 denotes re
T8831 15417-15418 SO:0001023 denotes e
T5521 9925-9933 GO:0042571 denotes antibody
T5520 9921-9924 PR:000017459 denotes WT1
T5519 9897-9914 UBERON:0006364 denotes ureteric bud tips
T5518 9855-9885 UBERON:0005107 denotes capping metanephric mesenchyme
T5517 9829-9839 GO:0042571 denotes antibodies
T5516 9816-9822 PR:000005505 denotes Cited1
T5515 9802-9805 PR:000017459 denotes Wt1
T5514 9767-9774 UBERON:0002113 denotes kidneys
T5513 9756-9761 PR:000013524 denotes Pygo2
T5512 9750-9755 PR:000013523 denotes Pygo1
T5511 9723-9740 GO:0001822 denotes renal development
T5510 9723-9728 UBERON:0002113 denotes renal
T5509 9633-9646 GO:0001822 denotes nephrogenesis
T5508 9589-9596 UBERON:0002113 denotes kidneys
T5507 9564-9569 PR:000013524 denotes Pygo2
T5506 9558-9563 PR:000013523 denotes Pygo1
T5505 9543-9548 PR:000013524 denotes Pygo2
T5504 9507-9514 UBERON:0002113 denotes kidneys
T5503 9494-9499 PR:000013524 denotes Pygo2
T5502 9488-9493 PR:000013523 denotes Pygo1
T8830 15414-15416 UBERON:0002329 denotes mi
T755 10-15 PR:000013524 denotes Pygo2
T756 25-38 GO:0016055 denotes Wnt signaling
T11828 24614-24621 UBERON:0001285 denotes nephron
T11827 24608-24613 UBERON:0007023 denotes adult
T11826 24584-24600 UBERON:0004134 denotes proximal tubules
T11825 24567-24576 GO:0010467 denotes expressed
T11824 24557-24563 PR:000015169 denotes Slc5a2
T11823 24535-24542 PR:000015966 denotes Slco1a4
T11822 24510-24516 PR:000015169 denotes Slc5a2
T11821 24489-24495 PR:000006067 denotes Cxcl13
T11820 24472-24479 UBERON:0002113 denotes kidneys
T11819 24429-24434 SO:0000704 denotes genes
T11818 24414-24421 UBERON:0002113 denotes kidneys
T8844 15669-15676 UBERON:0000922 denotes embryos
T8818 14019-14026 UBERON:0002329 denotes somites
T8817 13954-13960 UBERON:0000479 denotes tissue
T8816 13898-13921 GO:0060070 denotes canonical Wnt signaling
T8815 13869-13876 UBERON:0000922 denotes embryos
T8814 13845-13850 PR:000013524 denotes Pygo2
T8813 13839-13844 PR:000013523 denotes Pygo1
T8812 13826-13831 PR:000013524 denotes Pygo2
T8811 13815-13819 NCBITaxon:10088 denotes mice
T8810 13787-13800 GO:0016055 denotes Wnt signaling
T8829 15412-15413 GO:0010467 denotes x
T8828 15411-15412 UBERON:0000922 denotes e
T8827 15408-15409 SO:0000902 denotes s
T8826 15404-15405 UBERON:0000922 denotes e
T8825 15403-15404 GO:0060070 denotes W
T8824 14274-14281 UBERON:0000467 denotes systems
T8823 14215-14238 GO:0060070 denotes canonical Wnt signaling
T8822 14179-14184 SO:0000704 denotes genes
T8821 14164-14173 NCBITaxon:40674 denotes mammalian
T8820 14118-14131 GO:0016055 denotes Wnt signaling
T8819 14084-14097 UBERON:0001893 denotes telencephalon
T8856 18558-18559 PR:000013523 denotes y
T8855 18545-18547 GO:0010467 denotes pe
T8854 18539-18540 UBERON:0000922 denotes e
T8853 18532-18537 PR:000013524 denotes Pygo2
T8852 15975-15985 GO:0010467 denotes expression
T8851 15898-15910 UBERON:0000084 denotes ureteric bud
T8860 18641-18649 UBERON:0000056 denotes ureteric
T8859 18610-18633 GO:0060070 denotes canonical Wnt signaling
T8858 18588-18592 SO:0000704 denotes gene
T8857 18582-18587 PR:000013523 denotes Pygo1
T8962 21497-21504 UBERON:0002113 denotes kidneys
T8961 21488-21493 PR:000013524 denotes Pygo2
T8960 21479-21484 PR:000013523 denotes Pygo1
T8959 21436-21448 UBERON:0006364 denotes ureteric tip
T8958 21396-21409 UBERON:0006364 denotes ureteric tips
T8957 21349-21356 UBERON:0002113 denotes kidneys
T8956 21320-21326 UBERON:0002113 denotes kidney
T8955 21311-21316 PR:000013524 denotes Pygo2
T8954 21302-21307 PR:000013523 denotes Pygo1
T8953 21264-21274 GO:0010467 denotes expression
T8952 21222-21245 GO:0060070 denotes canonical Wnt signaling
T8951 21213-21218 PR:000013523 denotes Pygo1
T8950 21166-21176 GO:0010467 denotes expression
T8949 21120-21125 PR:000013524 denotes Pygo2
T8948 21111-21116 PR:000013523 denotes Pygo1
T8947 21033-21038 PR:000013524 denotes Pygo2
T8946 21024-21029 PR:000013523 denotes Pygo1
T8945 21011-21016 PR:000013523 denotes Pygo1
T8944 20991-21001 GO:0010467 denotes expression
T14976 34043-34048 PR:000017438 denotes Wnt11
T14975 34005-34028 GO:0060070 denotes canonical Wnt signaling
T14974 33991-33996 SO:0000704 denotes genes
T14973 33983-33990 PR:Q9V9W8 denotes Pygopus
T14972 33861-33866 PR:000017438 denotes Wnt11
T14971 33779-33784 PR:000017438 denotes Wnt11
T14970 33710-33722 UBERON:0000084 denotes ureteric bud
T14969 33710-33722 GO:0001658 denotes ureteric bud
T14968 33679-33705 _FRAGMENT denotes branching morphogenesis of
T14967 33645-33650 PR:000013524 denotes Pygo2
T14966 33639-33644 PR:000013523 denotes Pygo1
R1 T801 T800 _lexicallyChainedTo ureteric bud,Branching morphogenesis of
R2 T821 T820 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R394 T2469 T2468 _lexicallyChainedTo complex,formation of
R395 T2510 T2509 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R1255 T4592 T4591 _lexicallyChainedTo kidney,cells of
R1383 T5524 T5523 _lexicallyChainedTo glomerular,renal
R1384 T5548 T5547 _lexicallyChainedTo kidney,medulla of
R1733 T6275 T6274 _lexicallyChainedTo of,stalks
R1734 T6276 T6275 _lexicallyChainedTo ureteric bud,of
R1735 T6278 T6277 _lexicallyChainedTo ureteric bud,tips of
R1848 T8888 T8887 _lexicallyChainedTo ducts,paramesonephric
R1849 T8912 T8911 _lexicallyChainedTo kidney,cortex of
R1850 T8917 T8916 _lexicallyChainedTo of,collecting ducts
R1851 T8918 T8917 _lexicallyChainedTo kidney,of
R1852 T8975 T8974 _lexicallyChainedTo tubules,renal
R1853 T8976 T8974 _lexicallyChainedTo glomeruli,renal
R3015 T11838 T11837 _lexicallyChainedTo kidney,tubules of
R3617 T14881 T14880 _lexicallyChainedTo development,central nervous system
R3618 T14958 T14957 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R3619 T14969 T14968 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R4720 T17016 T17015 _lexicallyChainedTo ureteric bud,branching morphogenesis of
R4992 T18040 T18039 _lexicallyChainedTo exon,coding regions of
R6482 T22596 T22595 _lexicallyChainedTo kidney,cortex of
R6859 T24143 T24142 _lexicallyChainedTo limb buds,fore

2_test

Id Subject Object Predicate Lexical cue
17425782-3153305-8469427 2644-2645 3153305 denotes 1
17425782-16054034-8469428 2753-2754 16054034 denotes 2
17425782-7990960-8469429 2848-2849 7990960 denotes 3
17425782-12783789-8469430 3051-3052 12783789 denotes 4
17425782-7739543-8469431 3327-3328 7739543 denotes 5
17425782-15775981-8469431 3327-3328 15775981 denotes 5
17425782-12167861-8469431 3327-3328 12167861 denotes 5
17425782-16054034-8469432 3428-3429 16054034 denotes 2
17425782-12163411-8469433 3554-3555 12163411 denotes 8
17425782-11955446-8469433 3554-3555 11955446 denotes 8
17425782-12015286-8469433 3554-3555 12015286 denotes 8
17425782-11988739-8469433 3554-3555 11988739 denotes 8
17425782-15208637-8469434 3723-3725 15208637 denotes 12
17425782-11955446-8469435 3850-3851 11955446 denotes 9
17425782-16169192-8469436 3852-3854 16169192 denotes 13
17425782-11955446-8469437 4005-4006 11955446 denotes 9
17425782-16169192-8469438 4007-4009 16169192 denotes 13
17425782-12163411-8469439 4188-4189 12163411 denotes 8
17425782-11988739-8469440 4190-4192 11988739 denotes 11
17425782-11955446-8469441 4370-4371 11955446 denotes 9
17425782-12163411-8469442 4469-4470 12163411 denotes 8
17425782-11955446-8469443 4471-4472 11955446 denotes 9
17425782-15234002-8469444 4473-4475 15234002 denotes 14
17425782-8559668-8469445 5712-5714 8559668 denotes 15
17425782-12163411-8469446 6125-6126 12163411 denotes 8
17425782-15234002-8469447 6485-6487 15234002 denotes 14
17425782-15618518-8469448 6488-6490 15618518 denotes 16
17425782-15234002-8469449 8329-8331 15234002 denotes 14
17425782-15618518-8469450 8332-8334 15618518 denotes 16
17425782-2164159-8469451 9916-9918 2164159 denotes 17
17425782-3902535-8469452 10166-10168 3902535 denotes 18
17425782-15618518-8469453 10203-10205 15618518 denotes 16
17425782-9639355-8469454 10270-10272 9639355 denotes 19
17425782-15618518-8469455 11436-11438 15618518 denotes 16
17425782-15618518-8469456 12119-12121 15618518 denotes 16
17425782-8951078-8469457 12721-12723 8951078 denotes 20
17425782-12783789-8469458 12745-12746 12783789 denotes 4
17425782-16054034-8469459 12827-12828 16054034 denotes 2
17425782-12626757-8469460 13752-13754 12626757 denotes 21
17425782-12626757-8469461 22656-22658 12626757 denotes 21
17425782-16054034-8469462 22954-22955 16054034 denotes 2
17425782-7851662-8469463 23321-23323 7851662 denotes 22
17425782-12436245-8469464 24743-24745 12436245 denotes 23
17425782-12101011-8469465 24851-24853 12101011 denotes 24
17425782-15192120-8469466 27319-27321 15192120 denotes 25
17425782-12512695-8469467 27437-27439 12512695 denotes 26
17425782-16601496-8469468 27582-27584 16601496 denotes 27
17425782-10963667-8469469 27781-27783 10963667 denotes 28
17425782-10318916-8469470 28243-28245 10318916 denotes 29
17425782-10716946-8469471 28259-28261 10716946 denotes 30
17425782-12015286-8469472 30287-30289 12015286 denotes 10
17425782-12163411-8469473 30544-30545 12163411 denotes 8
17425782-12163411-8469474 31644-31645 12163411 denotes 8
17425782-12163411-8469475 31868-31869 12163411 denotes 8
17425782-16054034-8469476 32551-32552 16054034 denotes 2
17425782-16054034-8469477 32584-32585 16054034 denotes 2
17425782-7990960-8469478 32673-32674 7990960 denotes 3
17425782-12783789-8469479 32792-32793 12783789 denotes 4
17425782-12783789-8469480 33794-33795 12783789 denotes 4
17425782-15797385-8469481 33965-33967 15797385 denotes 31
17425782-16054034-8469482 34652-34653 16054034 denotes 2
17425782-16630820-8469483 37196-37198 16630820 denotes 32
17425782-16554443-8469484 37199-37201 16554443 denotes 33
17425782-14526104-8469485 38337-38339 14526104 denotes 34
17425782-8559668-8469486 39637-39639 8559668 denotes 15
17425782-11493536-8469487 41523-41525 11493536 denotes 35
17425782-11493536-8469488 41585-41587 11493536 denotes 35
17425782-16054034-8469489 41638-41639 16054034 denotes 2
17425782-12626757-8469490 42919-42921 12626757 denotes 21
17425782-16581055-8469491 43985-43987 16581055 denotes 36
17425782-10547847-8469492 45494-45496 10547847 denotes 37
17425782-11846609-8469493 45889-45891 11846609 denotes 38