PMC:1853120 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T816	0-103	sentence	denotes	A Mammal-Specific Doublesex Homolog Associates with Male Sex Chromatin and Is Required for Male Meiosis
T817	2-8	NN	denotes	Mammal
T818	9-17	JJ	denotes	Specific
T819	8-9	HYPH	denotes	-
T820	18-27	NN	denotes	Doublesex
T821	36-46	VBZ	denotes	Associates
T822	47-51	IN	denotes	with
T823	52-56	JJ	denotes	Male
T824	61-70	NN	denotes	Chromatin
T825	57-60	NN	denotes	Sex
T826	71-74	CC	denotes	and
T827	75-77	VBZ	denotes	Is
T828	78-86	VBN	denotes	Required
T829	87-90	IN	denotes	for
T830	91-95	JJ	denotes	Male
T831	96-103	NN	denotes	Meiosis
T832	103-274	sentence	denotes	A DM Domain Protein in Male Meiosis Abstract Gametogenesis is a sexually dimorphic process requiring profound differences in germ cell differentiation between the sexes.
T833	150-163	NN	denotes	Gametogenesis
T834	164-166	VBZ	denotes	is
T835	167-168	DT	denotes	a
T836	188-195	NN	denotes	process
T837	169-177	RB	denotes	sexually
T838	178-187	JJ	denotes	dimorphic
T839	196-205	VBG	denotes	requiring
T840	206-214	JJ	denotes	profound
T841	215-226	NNS	denotes	differences
T842	227-229	IN	denotes	in
T843	230-234	NN	denotes	germ
T844	235-239	NN	denotes	cell
T845	240-255	NN	denotes	differentiation
T846	256-263	IN	denotes	between
T847	264-267	DT	denotes	the
T848	268-273	NNS	denotes	sexes
T849	273-274	.	denotes	.
T850	274-447	sentence	denotes	In mammals, the presence of heteromorphic sex chromosomes in males creates additional sex-specific challenges, including incomplete X and Y pairing during meiotic prophase.
T851	275-277	IN	denotes	In
T852	342-349	VBZ	denotes	creates
T853	278-285	NNS	denotes	mammals
T854	285-287	,	denotes	,
T855	287-290	DT	denotes	the
T856	291-299	NN	denotes	presence
T857	300-302	IN	denotes	of
T858	303-316	JJ	denotes	heteromorphic
T859	321-332	NNS	denotes	chromosomes
T860	317-320	NN	denotes	sex
T861	333-335	IN	denotes	in
T862	336-341	NNS	denotes	males
T863	350-360	JJ	denotes	additional
T864	374-384	NNS	denotes	challenges
T865	361-364	NN	denotes	sex
T866	365-373	JJ	denotes	specific
T867	364-365	HYPH	denotes	-
T868	384-386	,	denotes	,
T869	386-395	VBG	denotes	including
T870	396-406	JJ	denotes	incomplete
T871	415-422	NN	denotes	pairing
T872	407-408	NN	denotes	X
T873	409-412	CC	denotes	and
T874	413-414	NN	denotes	Y
T875	423-429	IN	denotes	during
T876	430-437	JJ	denotes	meiotic
T877	438-446	NN	denotes	prophase
T878	446-447	.	denotes	.
T879	447-513	sentence	denotes	This triggers formation of a heterochromatin domain, the XY body.
T880	448-452	DT	denotes	This
T881	453-461	VBZ	denotes	triggers
T882	462-471	NN	denotes	formation
T883	472-474	IN	denotes	of
T884	475-476	DT	denotes	a
T885	493-499	NN	denotes	domain
T886	477-492	NN	denotes	heterochromatin
T887	499-501	,	denotes	,
T888	501-504	DT	denotes	the
T889	508-512	NN	denotes	body
T890	505-507	NN	denotes	XY
T891	512-513	.	denotes	.
T892	513-638	sentence	denotes	The XY body disassembles after prophase, but specialized sex chromatin persists, with further modification, through meiosis.
T893	514-517	DT	denotes	The
T894	521-525	NN	denotes	body
T895	518-520	NN	denotes	XY
T896	526-538	VBZ	denotes	disassembles
T897	539-544	IN	denotes	after
T898	545-553	NN	denotes	prophase
T899	553-555	,	denotes	,
T900	555-558	CC	denotes	but
T901	559-570	VBN	denotes	specialized
T902	575-584	NN	denotes	chromatin
T903	571-574	NN	denotes	sex
T904	585-593	VBZ	denotes	persists
T905	593-595	,	denotes	,
T906	595-599	IN	denotes	with
T907	600-607	JJ	denotes	further
T908	608-620	NN	denotes	modification
T909	620-622	,	denotes	,
T910	622-629	IN	denotes	through
T911	630-637	NN	denotes	meiosis
T912	637-638	.	denotes	.
T913	638-775	sentence	denotes	Here, we investigate the function of DMRT7, a mammal-specific protein related to the invertebrate sexual regulators Doublesex and MAB-3.
T914	639-643	RB	denotes	Here
T915	648-659	VBP	denotes	investigate
T916	643-645	,	denotes	,
T917	645-647	PRP	denotes	we
T918	660-663	DT	denotes	the
T919	664-672	NN	denotes	function
T920	673-675	IN	denotes	of
T921	676-681	NN	denotes	DMRT7
T922	681-683	,	denotes	,
T923	683-684	DT	denotes	a
T924	701-708	NN	denotes	protein
T925	685-691	NN	denotes	mammal
T926	692-700	JJ	denotes	specific
T927	691-692	HYPH	denotes	-
T928	709-716	VBN	denotes	related
T929	717-719	IN	denotes	to
T930	720-723	DT	denotes	the
T931	744-754	NNS	denotes	regulators
T932	724-736	NN	denotes	invertebrate
T933	737-743	JJ	denotes	sexual
T934	755-764	NN	denotes	Doublesex
T935	765-768	CC	denotes	and
T936	769-772	NN	denotes	MAB
T937	772-773	HYPH	denotes	-
T938	773-774	CD	denotes	3
T939	774-775	.	denotes	.
T940	775-911	sentence	denotes	We find that DMRT7 preferentially localizes to the XY body in the pachytene stage of meiotic prophase and is required for male meiosis.
T941	776-778	PRP	denotes	We
T942	779-783	VBP	denotes	find
T943	784-788	IN	denotes	that
T944	810-819	VBZ	denotes	localizes
T945	789-794	NN	denotes	DMRT7
T946	795-809	RB	denotes	preferentially
T947	820-822	IN	denotes	to
T948	823-826	DT	denotes	the
T949	830-834	NN	denotes	body
T950	827-829	NN	denotes	XY
T951	835-837	IN	denotes	in
T952	838-841	DT	denotes	the
T953	852-857	NN	denotes	stage
T954	842-851	NN	denotes	pachytene
T955	858-860	IN	denotes	of
T956	861-868	JJ	denotes	meiotic
T957	869-877	NN	denotes	prophase
T958	878-881	CC	denotes	and
T959	882-884	VBZ	denotes	is
T960	885-893	VBN	denotes	required
T961	894-897	IN	denotes	for
T962	898-902	JJ	denotes	male
T963	903-910	NN	denotes	meiosis
T964	910-911	.	denotes	.
T965	911-1119	sentence	denotes	In Dmrt7 mutants, meiotic pairing and recombination appear normal, and a transcriptionally silenced XY body with appropriate chromatin marks is formed, but most germ cells undergo apoptosis during pachynema.
T966	912-914	IN	denotes	In
T967	964-970	VBP	denotes	appear
T968	915-920	NN	denotes	Dmrt7
T969	921-928	NNS	denotes	mutants
T970	928-930	,	denotes	,
T971	930-937	JJ	denotes	meiotic
T972	938-945	NN	denotes	pairing
T973	946-949	CC	denotes	and
T974	950-963	NN	denotes	recombination
T975	971-977	JJ	denotes	normal
T976	977-979	,	denotes	,
T977	979-982	CC	denotes	and
T978	983-984	DT	denotes	a
T979	1015-1019	NN	denotes	body
T980	985-1002	RB	denotes	transcriptionally
T981	1003-1011	VBN	denotes	silenced
T982	1012-1014	NN	denotes	XY
T983	1056-1062	VBN	denotes	formed
T984	1020-1024	IN	denotes	with
T985	1025-1036	JJ	denotes	appropriate
T986	1047-1052	NNS	denotes	marks
T987	1037-1046	NN	denotes	chromatin
T988	1053-1055	VBZ	denotes	is
T989	1062-1064	,	denotes	,
T990	1064-1067	CC	denotes	but
T991	1068-1072	JJS	denotes	most
T992	1078-1083	NNS	denotes	cells
T993	1073-1077	NN	denotes	germ
T994	1084-1091	VBP	denotes	undergo
T995	1092-1101	NN	denotes	apoptosis
T996	1102-1108	IN	denotes	during
T997	1109-1118	NN	denotes	pachynema
T998	1118-1119	.	denotes	.
T999	1119-1390	sentence	denotes	A minority of mutant cells can progress to diplonema, but many of these escaping cells have abnormal sex chromatin lacking histone H3K9 di- and trimethylation and heterochromatin protein 1β accumulation, modifications that normally occur between pachynema and diplonema.
T1000	1120-1121	DT	denotes	A
T1001	1122-1130	NN	denotes	minority
T1002	1151-1159	VB	denotes	progress
T1003	1131-1133	IN	denotes	of
T1004	1134-1140	NN	denotes	mutant
T1005	1141-1146	NNS	denotes	cells
T1006	1147-1150	MD	denotes	can
T1007	1160-1162	IN	denotes	to
T1008	1163-1172	NN	denotes	diplonema
T1009	1172-1174	,	denotes	,
T1010	1174-1177	CC	denotes	but
T1011	1178-1182	JJ	denotes	many
T1012	1207-1211	VBP	denotes	have
T1013	1183-1185	IN	denotes	of
T1014	1186-1191	DT	denotes	these
T1015	1201-1206	NNS	denotes	cells
T1016	1192-1200	VBG	denotes	escaping
T1017	1212-1220	JJ	denotes	abnormal
T1018	1225-1234	NN	denotes	chromatin
T1019	1221-1224	NN	denotes	sex
T1020	1235-1242	VBG	denotes	lacking
T1021	1243-1250	NN	denotes	histone
T1022	1264-1278	NN	denotes	trimethylation
T1023	1251-1255	NN	denotes	H3K9
T1024	1256-1258	AFX	denotes	di
T1025	1258-1259	HYPH	denotes	-
T1026	1260-1263	CC	denotes	and
T1027	1279-1282	CC	denotes	and
T1028	1283-1298	NN	denotes	heterochromatin
T1029	1310-1322	NN	denotes	accumulation
T1030	1299-1306	NN	denotes	protein
T1031	1307-1309	NN	denotes	1β
T1032	1322-1324	,	denotes	,
T1033	1324-1337	NNS	denotes	modifications
T1034	1338-1342	WDT	denotes	that
T1035	1352-1357	VBP	denotes	occur
T1036	1343-1351	RB	denotes	normally
T1037	1358-1365	IN	denotes	between
T1038	1366-1375	NN	denotes	pachynema
T1039	1376-1379	CC	denotes	and
T1040	1380-1389	NN	denotes	diplonema
T1041	1389-1390	.	denotes	.
T1042	1390-1614	sentence	denotes	Based on the localization of DMRT7 to the XY body and the sex chromatin defects observed in Dmrt7 mutants, we conclude that DMRT7 plays a role in the sex chromatin transformation that occurs between pachynema and diplonema.
T1043	1391-1396	VBN	denotes	Based
T1044	1501-1509	VBP	denotes	conclude
T1045	1397-1399	IN	denotes	on
T1046	1400-1403	DT	denotes	the
T1047	1404-1416	NN	denotes	localization
T1048	1417-1419	IN	denotes	of
T1049	1420-1425	NN	denotes	DMRT7
T1050	1426-1428	IN	denotes	to
T1051	1429-1432	DT	denotes	the
T1052	1436-1440	NN	denotes	body
T1053	1433-1435	NN	denotes	XY
T1054	1441-1444	CC	denotes	and
T1055	1445-1448	DT	denotes	the
T1056	1463-1470	NNS	denotes	defects
T1057	1449-1452	NN	denotes	sex
T1058	1453-1462	NN	denotes	chromatin
T1059	1471-1479	VBN	denotes	observed
T1060	1480-1482	IN	denotes	in
T1061	1483-1488	NN	denotes	Dmrt7
T1062	1489-1496	NNS	denotes	mutants
T1063	1496-1498	,	denotes	,
T1064	1498-1500	PRP	denotes	we
T1065	1510-1514	IN	denotes	that
T1066	1521-1526	VBZ	denotes	plays
T1067	1515-1520	NN	denotes	DMRT7
T1068	1527-1528	DT	denotes	a
T1069	1529-1533	NN	denotes	role
T1070	1534-1536	IN	denotes	in
T1071	1537-1540	DT	denotes	the
T1072	1555-1569	NN	denotes	transformation
T1073	1541-1544	NN	denotes	sex
T1074	1545-1554	NN	denotes	chromatin
T1075	1570-1574	WDT	denotes	that
T1076	1575-1581	VBZ	denotes	occurs
T1077	1582-1589	IN	denotes	between
T1078	1590-1599	NN	denotes	pachynema
T1079	1600-1603	CC	denotes	and
T1080	1604-1613	NN	denotes	diplonema
T1081	1613-1614	.	denotes	.
T1082	1614-1748	sentence	denotes	We suggest that DMRT7 may help control the transition from meiotic sex chromosome inactivation to postmeiotic sex chromatin in males.
T1083	1615-1617	PRP	denotes	We
T1084	1618-1625	VBP	denotes	suggest
T1085	1626-1630	IN	denotes	that
T1086	1641-1645	VB	denotes	help
T1087	1631-1636	NN	denotes	DMRT7
T1088	1637-1640	MD	denotes	may
T1089	1646-1653	VB	denotes	control
T1090	1654-1657	DT	denotes	the
T1091	1658-1668	NN	denotes	transition
T1092	1669-1673	IN	denotes	from
T1093	1674-1681	JJ	denotes	meiotic
T1094	1686-1696	NN	denotes	chromosome
T1095	1682-1685	NN	denotes	sex
T1096	1697-1709	NN	denotes	inactivation
T1097	1710-1712	IN	denotes	to
T1098	1713-1724	JJ	denotes	postmeiotic
T1099	1729-1738	NN	denotes	chromatin
T1100	1725-1728	NN	denotes	sex
T1101	1739-1741	IN	denotes	in
T1102	1742-1747	NNS	denotes	males
T1103	1747-1748	.	denotes	.
T1104	1748-1906	sentence	denotes	In addition, because it is found in all branches of mammals, but not in other vertebrates, Dmrt7 may shed light on evolution of meiosis and of sex chromatin.
T1105	1749-1751	IN	denotes	In
T1106	1850-1854	VB	denotes	shed
T1107	1752-1760	NN	denotes	addition
T1108	1760-1762	,	denotes	,
T1109	1762-1769	IN	denotes	because
T1110	1776-1781	VBN	denotes	found
T1111	1770-1772	PRP	denotes	it
T1112	1773-1775	VBZ	denotes	is
T1113	1782-1784	IN	denotes	in
T1114	1785-1788	DT	denotes	all
T1115	1789-1797	NNS	denotes	branches
T1116	1798-1800	IN	denotes	of
T1117	1801-1808	NNS	denotes	mammals
T1118	1808-1810	,	denotes	,
T1119	1810-1813	CC	denotes	but
T1120	1814-1817	RB	denotes	not
T1121	1818-1820	IN	denotes	in
T1122	1821-1826	JJ	denotes	other
T1123	1827-1838	NNS	denotes	vertebrates
T1124	1838-1840	,	denotes	,
T1125	1840-1845	NN	denotes	Dmrt7
T1126	1846-1849	MD	denotes	may
T1127	1855-1860	NN	denotes	light
T1128	1861-1863	IN	denotes	on
T1129	1864-1873	NN	denotes	evolution
T1130	1874-1876	IN	denotes	of
T1131	1877-1884	NN	denotes	meiosis
T1132	1885-1888	CC	denotes	and
T1133	1889-1891	IN	denotes	of
T1134	1892-1895	NN	denotes	sex
T1135	1896-1905	NN	denotes	chromatin
T1136	1905-1906	.	denotes	.
T3987	3096-3102	JJ	denotes	Sexual
T3988	3103-3118	NN	denotes	differentiation
T3989	3119-3128	VBZ	denotes	generates
T3990	3129-3139	JJ	denotes	anatomical
T3991	3171-3182	NNS	denotes	dimorphisms
T3992	3139-3141	,	denotes	,
T3993	3141-3154	JJ	denotes	physiological
T3994	3154-3156	,	denotes	,
T3995	3156-3159	CC	denotes	and
T3996	3160-3170	JJ	denotes	behavioral
T3997	3183-3187	WDT	denotes	that
T3998	3188-3191	VBP	denotes	are
T3999	3192-3201	JJ	denotes	essential
T4000	3202-3205	IN	denotes	for
T4001	3206-3212	JJ	denotes	sexual
T4002	3213-3225	NN	denotes	reproduction
T4003	3225-3226	.	denotes	.
T4004	3226-3385	sentence	denotes	Many of these dimorphisms affect somatic cells, but the sexual dimorphisms that most directly mediate sexual reproduction are those of the gametes themselves.
T4005	3227-3231	JJ	denotes	Many
T4006	3253-3259	VBP	denotes	affect
T4007	3232-3234	IN	denotes	of
T4008	3235-3240	DT	denotes	these
T4009	3241-3252	NNS	denotes	dimorphisms
T4010	3260-3267	JJ	denotes	somatic
T4011	3268-3273	NNS	denotes	cells
T4012	3273-3275	,	denotes	,
T4013	3275-3278	CC	denotes	but
T4014	3279-3282	DT	denotes	the
T4015	3290-3301	NNS	denotes	dimorphisms
T4016	3283-3289	JJ	denotes	sexual
T4017	3349-3352	VBP	denotes	are
T4018	3302-3306	WDT	denotes	that
T4019	3321-3328	VB	denotes	mediate
T4020	3307-3311	RBS	denotes	most
T4021	3312-3320	RB	denotes	directly
T4022	3329-3335	JJ	denotes	sexual
T4023	3336-3348	NN	denotes	reproduction
T4024	3353-3358	DT	denotes	those
T4025	3359-3361	IN	denotes	of
T4026	3362-3365	DT	denotes	the
T4027	3366-3373	NNS	denotes	gametes
T4028	3374-3384	PRP	denotes	themselves
T4029	3384-3385	.	denotes	.
T4030	3385-3528	sentence	denotes	Gametes differ between the sexes in size and morphology, sometimes dramatically so, reflecting their very different roles in zygote formation.
T4031	3386-3393	NNS	denotes	Gametes
T4032	3394-3400	VBP	denotes	differ
T4033	3401-3408	IN	denotes	between
T4034	3409-3412	DT	denotes	the
T4035	3413-3418	NNS	denotes	sexes
T4036	3419-3421	IN	denotes	in
T4037	3422-3426	NN	denotes	size
T4038	3427-3430	CC	denotes	and
T4039	3431-3441	NN	denotes	morphology
T4040	3441-3443	,	denotes	,
T4041	3443-3452	RB	denotes	sometimes
T4042	3466-3468	RB	denotes	so
T4043	3453-3465	RB	denotes	dramatically
T4044	3468-3470	,	denotes	,
T4045	3470-3480	VBG	denotes	reflecting
T4046	3481-3486	PRP$	denotes	their
T4047	3502-3507	NNS	denotes	roles
T4048	3487-3491	RB	denotes	very
T4049	3492-3501	JJ	denotes	different
T4050	3508-3510	IN	denotes	in
T4051	3511-3517	NN	denotes	zygote
T4052	3518-3527	NN	denotes	formation
T4053	3527-3528	.	denotes	.
T4054	3528-3676	sentence	denotes	Indeed, the morphology of the gametes is what defines sex: females are the sex that produces the larger gametes and males produce the smaller ones.
T4055	3529-3535	RB	denotes	Indeed
T4056	3567-3569	VBZ	denotes	is
T4057	3535-3537	,	denotes	,
T4058	3537-3540	DT	denotes	the
T4059	3541-3551	NN	denotes	morphology
T4060	3552-3554	IN	denotes	of
T4061	3555-3558	DT	denotes	the
T4062	3559-3566	NNS	denotes	gametes
T4063	3596-3599	VBP	denotes	are
T4064	3570-3574	WP	denotes	what
T4065	3575-3582	VBZ	denotes	defines
T4066	3583-3586	NN	denotes	sex
T4067	3586-3588	:	denotes	:
T4068	3588-3595	NNS	denotes	females
T4069	3600-3603	DT	denotes	the
T4070	3604-3607	NN	denotes	sex
T4071	3608-3612	WDT	denotes	that
T4072	3613-3621	VBZ	denotes	produces
T4073	3622-3625	DT	denotes	the
T4074	3633-3640	NNS	denotes	gametes
T4075	3626-3632	JJR	denotes	larger
T4076	3641-3644	CC	denotes	and
T4077	3645-3650	NNS	denotes	males
T4078	3651-3658	VBP	denotes	produce
T4079	3659-3662	DT	denotes	the
T4080	3671-3675	NNS	denotes	ones
T4081	3663-3670	JJR	denotes	smaller
T4082	3675-3676	.	denotes	.
T4083	3676-3811	sentence	denotes	Mammalian meiosis is regulated sex-specifically starting in embryogenesis and continuing through much of adult life (reviewed in [1]).
T4084	3677-3686	JJ	denotes	Mammalian
T4085	3687-3694	NN	denotes	meiosis
T4086	3698-3707	VBN	denotes	regulated
T4087	3695-3697	VBZ	denotes	is
T4088	3708-3711	NN	denotes	sex
T4089	3712-3724	RB	denotes	specifically
T4090	3711-3712	HYPH	denotes	-
T4091	3725-3733	VBG	denotes	starting
T4092	3734-3736	IN	denotes	in
T4093	3737-3750	NN	denotes	embryogenesis
T4094	3751-3754	CC	denotes	and
T4095	3755-3765	VBG	denotes	continuing
T4096	3766-3773	IN	denotes	through
T4097	3774-3778	JJ	denotes	much
T4098	3779-3781	IN	denotes	of
T4099	3782-3787	JJ	denotes	adult
T4100	3788-3792	NN	denotes	life
T4101	3793-3794	-LRB-	denotes	(
T4102	3794-3802	VBN	denotes	reviewed
T4103	3803-3805	IN	denotes	in
T4104	3806-3807	-LRB-	denotes	[
T4105	3807-3808	CD	denotes	1
T4106	3808-3809	-RRB-	denotes	]
T4107	3809-3810	-RRB-	denotes	)
T4108	3810-3811	.	denotes	.
T4109	3811-3897	sentence	denotes	For example, the timing and synchrony of meiosis are very different in the two sexes.
T4110	3812-3815	IN	denotes	For
T4111	3861-3864	VBP	denotes	are
T4112	3816-3823	NN	denotes	example
T4113	3823-3825	,	denotes	,
T4114	3825-3828	DT	denotes	the
T4115	3829-3835	NN	denotes	timing
T4116	3836-3839	CC	denotes	and
T4117	3840-3849	NN	denotes	synchrony
T4118	3850-3852	IN	denotes	of
T4119	3853-3860	NN	denotes	meiosis
T4120	3865-3869	RB	denotes	very
T4121	3870-3879	JJ	denotes	different
T4122	3880-3882	IN	denotes	in
T4123	3883-3886	DT	denotes	the
T4124	3891-3896	NNS	denotes	sexes
T4125	3887-3890	CD	denotes	two
T4126	3896-3897	.	denotes	.
T4127	3897-4003	sentence	denotes	In females, germ cells synchronously initiate meiosis in the embryo and arrest during meiotic prophase I.
T4128	3898-3900	IN	denotes	In
T4129	3935-3943	VBP	denotes	initiate
T4130	3901-3908	NNS	denotes	females
T4131	3908-3910	,	denotes	,
T4132	3910-3914	NN	denotes	germ
T4133	3915-3920	NNS	denotes	cells
T4134	3921-3934	RB	denotes	synchronously
T4135	3944-3951	NN	denotes	meiosis
T4136	3952-3954	IN	denotes	in
T4137	3955-3958	DT	denotes	the
T4138	3959-3965	NN	denotes	embryo
T4139	3966-3969	CC	denotes	and
T4140	3970-3976	VBP	denotes	arrest
T4141	3977-3983	IN	denotes	during
T4142	3984-3991	JJ	denotes	meiotic
T4143	3992-4000	NN	denotes	prophase
T4144	4001-4002	CD	denotes	I
T4145	4002-4003	.	denotes	.
T4146	4003-4159	sentence	denotes	After puberty, oocytes are selectively recruited for ovulation, when they proceed to metaphase II and then complete meiosis after fertilization occurs [2].
T4147	4004-4009	IN	denotes	After
T4148	4043-4052	VBN	denotes	recruited
T4149	4010-4017	NN	denotes	puberty
T4150	4017-4019	,	denotes	,
T4151	4019-4026	NNS	denotes	oocytes
T4152	4027-4030	VBP	denotes	are
T4153	4031-4042	RB	denotes	selectively
T4154	4053-4056	IN	denotes	for
T4155	4057-4066	NN	denotes	ovulation
T4156	4066-4068	,	denotes	,
T4157	4068-4072	WRB	denotes	when
T4158	4078-4085	VBP	denotes	proceed
T4159	4073-4077	PRP	denotes	they
T4160	4086-4088	IN	denotes	to
T4161	4089-4098	NN	denotes	metaphase
T4162	4099-4101	CD	denotes	II
T4163	4102-4105	CC	denotes	and
T4164	4106-4110	RB	denotes	then
T4165	4111-4119	VBP	denotes	complete
T4166	4120-4127	NN	denotes	meiosis
T4167	4128-4133	IN	denotes	after
T4168	4148-4154	VBZ	denotes	occurs
T4169	4134-4147	NN	denotes	fertilization
T4170	4155-4156	-LRB-	denotes	[
T4171	4156-4157	CD	denotes	2
T4172	4157-4158	-RRB-	denotes	]
T4173	4158-4159	.	denotes	.
T4174	4159-4259	sentence	denotes	In contrast, male meiosis occurs entirely postnatally, without the arrest periods found in females.
T4175	4160-4162	IN	denotes	In
T4176	4186-4192	VBZ	denotes	occurs
T4177	4163-4171	NN	denotes	contrast
T4178	4171-4173	,	denotes	,
T4179	4173-4177	JJ	denotes	male
T4180	4178-4185	NN	denotes	meiosis
T4181	4193-4201	RB	denotes	entirely
T4182	4202-4213	RB	denotes	postnatally
T4183	4213-4215	,	denotes	,
T4184	4215-4222	IN	denotes	without
T4185	4223-4226	DT	denotes	the
T4186	4234-4241	NNS	denotes	periods
T4187	4227-4233	NN	denotes	arrest
T4188	4242-4247	VBN	denotes	found
T4189	4248-4250	IN	denotes	in
T4190	4251-4258	NNS	denotes	females
T4191	4258-4259	.	denotes	.
T4192	4259-4419	sentence	denotes	In females, each meiosis can produce a single haploid oocyte (and two extruded polar bodies), whereas each male meiosis can produce four haploid spermatocytes.
T4193	4260-4262	IN	denotes	In
T4194	4289-4296	VB	denotes	produce
T4195	4263-4270	NNS	denotes	females
T4196	4270-4272	,	denotes	,
T4197	4272-4276	DT	denotes	each
T4198	4277-4284	NN	denotes	meiosis
T4199	4285-4288	MD	denotes	can
T4200	4297-4298	DT	denotes	a
T4201	4314-4320	NN	denotes	oocyte
T4202	4299-4305	JJ	denotes	single
T4203	4306-4313	NN	denotes	haploid
T4204	4321-4322	-LRB-	denotes	(
T4205	4322-4325	CC	denotes	and
T4206	4326-4329	CD	denotes	two
T4207	4345-4351	NNS	denotes	bodies
T4208	4330-4338	VBN	denotes	extruded
T4209	4339-4344	JJ	denotes	polar
T4210	4351-4352	-RRB-	denotes	)
T4211	4352-4354	,	denotes	,
T4212	4354-4361	IN	denotes	whereas
T4213	4384-4391	VB	denotes	produce
T4214	4362-4366	DT	denotes	each
T4215	4372-4379	NN	denotes	meiosis
T4216	4367-4371	JJ	denotes	male
T4217	4380-4383	MD	denotes	can
T4218	4392-4396	CD	denotes	four
T4219	4405-4418	NNS	denotes	spermatocytes
T4220	4397-4404	NN	denotes	haploid
T4221	4418-4419	.	denotes	.
T4222	4419-4555	sentence	denotes	Other meiotic processes, such as recombination and chromosome pairing (synapsis), occur in both sexes but operate somewhat differently.
T4223	4420-4425	JJ	denotes	Other
T4224	4434-4443	NNS	denotes	processes
T4225	4426-4433	JJ	denotes	meiotic
T4226	4502-4507	VBP	denotes	occur
T4227	4443-4445	,	denotes	,
T4228	4445-4449	JJ	denotes	such
T4229	4450-4452	IN	denotes	as
T4230	4453-4466	NN	denotes	recombination
T4231	4467-4470	CC	denotes	and
T4232	4471-4481	NN	denotes	chromosome
T4233	4482-4489	NN	denotes	pairing
T4234	4490-4491	-LRB-	denotes	(
T4235	4491-4499	NN	denotes	synapsis
T4236	4499-4500	-RRB-	denotes	)
T4237	4500-4502	,	denotes	,
T4238	4508-4510	IN	denotes	in
T4239	4511-4515	CC	denotes	both
T4240	4516-4521	NNS	denotes	sexes
T4241	4522-4525	CC	denotes	but
T4242	4526-4533	VBP	denotes	operate
T4243	4534-4542	RB	denotes	somewhat
T4244	4543-4554	RB	denotes	differently
T4245	4554-4555	.	denotes	.
T4246	4555-4837	sentence	denotes	For example, there is a higher failure rate for meiosis in females, with human oocyte aneuploidy rates up to 25% versus about 2% in human sperm [3], and this may indicate that the checkpoints controlling and monitoring the events of meiotic progression in males are more stringent.
T4247	4556-4559	IN	denotes	For
T4248	4575-4577	VBZ	denotes	is
T4249	4560-4567	NN	denotes	example
T4250	4567-4569	,	denotes	,
T4251	4569-4574	EX	denotes	there
T4252	4578-4579	DT	denotes	a
T4253	4595-4599	NN	denotes	rate
T4254	4580-4586	JJR	denotes	higher
T4255	4587-4594	NN	denotes	failure
T4256	4600-4603	IN	denotes	for
T4257	4604-4611	NN	denotes	meiosis
T4258	4612-4614	IN	denotes	in
T4259	4615-4622	NNS	denotes	females
T4260	4622-4624	,	denotes	,
T4261	4624-4628	IN	denotes	with
T4262	4629-4634	JJ	denotes	human
T4263	4653-4658	NNS	denotes	rates
T4264	4635-4641	NN	denotes	oocyte
T4265	4642-4652	NN	denotes	aneuploidy
T4266	4659-4661	IN	denotes	up
T4267	4665-4667	CD	denotes	25
T4268	4662-4664	IN	denotes	to
T4269	4667-4668	NN	denotes	%
T4270	4669-4675	CC	denotes	versus
T4271	4676-4681	IN	denotes	about
T4272	4682-4683	CD	denotes	2
T4273	4683-4684	NN	denotes	%
T4274	4685-4687	IN	denotes	in
T4275	4688-4693	JJ	denotes	human
T4276	4694-4699	NN	denotes	sperm
T4277	4700-4701	-LRB-	denotes	[
T4278	4701-4702	CD	denotes	3
T4279	4702-4703	-RRB-	denotes	]
T4280	4703-4705	,	denotes	,
T4281	4705-4708	CC	denotes	and
T4282	4709-4713	DT	denotes	this
T4283	4718-4726	VB	denotes	indicate
T4284	4714-4717	MD	denotes	may
T4285	4727-4731	IN	denotes	that
T4286	4818-4821	VBP	denotes	are
T4287	4732-4735	DT	denotes	the
T4288	4736-4747	NNS	denotes	checkpoints
T4289	4748-4759	VBG	denotes	controlling
T4290	4760-4763	CC	denotes	and
T4291	4764-4774	VBG	denotes	monitoring
T4292	4775-4778	DT	denotes	the
T4293	4779-4785	NNS	denotes	events
T4294	4786-4788	IN	denotes	of
T4295	4789-4796	JJ	denotes	meiotic
T4296	4797-4808	NN	denotes	progression
T4297	4809-4811	IN	denotes	in
T4298	4812-4817	NNS	denotes	males
T4299	4822-4826	RBR	denotes	more
T4300	4827-4836	JJ	denotes	stringent
T4301	4836-4837	.	denotes	.
T4302	4837-5011	sentence	denotes	Consistent with this idea, genetic analysis of a number of meiotic regulatory genes in the mouse has demonstrated a much stronger requirement in males than in females [1,4].
T4303	4838-4848	JJ	denotes	Consistent
T4304	4939-4951	VBN	denotes	demonstrated
T4305	4849-4853	IN	denotes	with
T4306	4854-4858	DT	denotes	this
T4307	4859-4863	NN	denotes	idea
T4308	4863-4865	,	denotes	,
T4309	4865-4872	JJ	denotes	genetic
T4310	4873-4881	NN	denotes	analysis
T4311	4882-4884	IN	denotes	of
T4312	4885-4886	DT	denotes	a
T4313	4887-4893	NN	denotes	number
T4314	4894-4896	IN	denotes	of
T4315	4897-4904	JJ	denotes	meiotic
T4316	4916-4921	NNS	denotes	genes
T4317	4905-4915	JJ	denotes	regulatory
T4318	4922-4924	IN	denotes	in
T4319	4925-4928	DT	denotes	the
T4320	4929-4934	NN	denotes	mouse
T4321	4935-4938	VBZ	denotes	has
T4322	4952-4953	DT	denotes	a
T4323	4968-4979	NN	denotes	requirement
T4324	4954-4958	RB	denotes	much
T4325	4959-4967	JJR	denotes	stronger
T4326	4980-4982	IN	denotes	in
T4327	4983-4988	NNS	denotes	males
T4328	4989-4993	IN	denotes	than
T4329	4994-4996	IN	denotes	in
T4330	4997-5004	NNS	denotes	females
T4331	5005-5006	-LRB-	denotes	[
T4332	5008-5009	CD	denotes	4
T4333	5006-5007	CD	denotes	1
T4334	5007-5008	,	denotes	,
T4335	5009-5010	-RRB-	denotes	]
T4336	5010-5011	.	denotes	.
T4337	5011-5129	sentence	denotes	The existence of heteromorphic sex chromosomes, such as the XX/XY system of mammals, creates sex-specific challenges.
T4338	5012-5015	DT	denotes	The
T4339	5016-5025	NN	denotes	existence
T4340	5097-5104	VBZ	denotes	creates
T4341	5026-5028	IN	denotes	of
T4342	5029-5042	JJ	denotes	heteromorphic
T4343	5047-5058	NNS	denotes	chromosomes
T4344	5043-5046	NN	denotes	sex
T4345	5058-5060	,	denotes	,
T4346	5060-5064	JJ	denotes	such
T4347	5065-5067	IN	denotes	as
T4348	5068-5071	DT	denotes	the
T4349	5078-5084	NN	denotes	system
T4350	5072-5074	NN	denotes	XX
T4351	5075-5077	NN	denotes	XY
T4352	5074-5075	HYPH	denotes	/
T4353	5085-5087	IN	denotes	of
T4354	5088-5095	NNS	denotes	mammals
T4355	5095-5097	,	denotes	,
T4356	5105-5108	NN	denotes	sex
T4357	5109-5117	JJ	denotes	specific
T4358	5108-5109	HYPH	denotes	-
T4359	5118-5128	NNS	denotes	challenges
T4360	5128-5129	.	denotes	.
T4361	5129-5301	sentence	denotes	One is the need for mechanisms to balance expression of sex-linked genes between the sexes, which in mammals is accomplished by X chromosome inactivation in females [5,6].
T4362	5130-5133	CD	denotes	One
T4363	5134-5136	VBZ	denotes	is
T4364	5137-5140	DT	denotes	the
T4365	5141-5145	NN	denotes	need
T4366	5146-5149	IN	denotes	for
T4367	5150-5160	NNS	denotes	mechanisms
T4368	5161-5163	TO	denotes	to
T4369	5164-5171	VB	denotes	balance
T4370	5172-5182	NN	denotes	expression
T4371	5183-5185	IN	denotes	of
T4372	5186-5189	NN	denotes	sex
T4373	5190-5196	VBN	denotes	linked
T4374	5189-5190	HYPH	denotes	-
T4375	5197-5202	NNS	denotes	genes
T4376	5203-5210	IN	denotes	between
T4377	5211-5214	DT	denotes	the
T4378	5215-5220	NNS	denotes	sexes
T4379	5220-5222	,	denotes	,
T4380	5222-5227	WDT	denotes	which
T4381	5242-5254	VBN	denotes	accomplished
T4382	5228-5230	IN	denotes	in
T4383	5231-5238	NNS	denotes	mammals
T4384	5239-5241	VBZ	denotes	is
T4385	5255-5257	IN	denotes	by
T4386	5258-5259	NN	denotes	X
T4387	5260-5270	NN	denotes	chromosome
T4388	5271-5283	NN	denotes	inactivation
T4389	5284-5286	IN	denotes	in
T4390	5287-5294	NNS	denotes	females
T4391	5295-5296	-LRB-	denotes	[
T4392	5298-5299	CD	denotes	6
T4393	5296-5297	CD	denotes	5
T4394	5297-5298	,	denotes	,
T4395	5299-5300	-RRB-	denotes	]
T4396	5300-5301	.	denotes	.
T4397	5301-5380	sentence	denotes	In male germ cells there is another sex-specific consideration during meiosis.
T4398	5302-5304	IN	denotes	In
T4399	5327-5329	VBZ	denotes	is
T4400	5305-5309	JJ	denotes	male
T4401	5315-5320	NNS	denotes	cells
T4402	5310-5314	NN	denotes	germ
T4403	5321-5326	EX	denotes	there
T4404	5330-5337	DT	denotes	another
T4405	5351-5364	NN	denotes	consideration
T4406	5338-5341	NN	denotes	sex
T4407	5342-5350	JJ	denotes	specific
T4408	5341-5342	HYPH	denotes	-
T4409	5365-5371	IN	denotes	during
T4410	5372-5379	NN	denotes	meiosis
T4411	5379-5380	.	denotes	.
T4412	5380-5609	sentence	denotes	In prophase I, when the homologous chromosomes synapse and homologous recombination occurs, X and Y chromosome pairing is limited to a region termed the pseudoautosomal region, leaving large portions of each chromosome unpaired.
T4413	5381-5383	IN	denotes	In
T4414	5503-5510	VBN	denotes	limited
T4415	5384-5392	NN	denotes	prophase
T4416	5393-5394	CD	denotes	I
T4417	5394-5396	,	denotes	,
T4418	5396-5400	WRB	denotes	when
T4419	5428-5435	VBP	denotes	synapse
T4420	5401-5404	DT	denotes	the
T4421	5416-5427	NNS	denotes	chromosomes
T4422	5405-5415	JJ	denotes	homologous
T4423	5436-5439	CC	denotes	and
T4424	5440-5450	JJ	denotes	homologous
T4425	5451-5464	NN	denotes	recombination
T4426	5465-5471	VBZ	denotes	occurs
T4427	5471-5473	,	denotes	,
T4428	5473-5474	NN	denotes	X
T4429	5481-5491	NN	denotes	chromosome
T4430	5475-5478	CC	denotes	and
T4431	5479-5480	NN	denotes	Y
T4432	5492-5499	NN	denotes	pairing
T4433	5500-5502	VBZ	denotes	is
T4434	5511-5513	IN	denotes	to
T4435	5514-5515	DT	denotes	a
T4436	5516-5522	NN	denotes	region
T4437	5523-5529	VBN	denotes	termed
T4438	5530-5533	DT	denotes	the
T4439	5550-5556	NN	denotes	region
T4440	5534-5549	JJ	denotes	pseudoautosomal
T4441	5556-5558	,	denotes	,
T4442	5558-5565	VBG	denotes	leaving
T4443	5566-5571	JJ	denotes	large
T4444	5572-5580	NNS	denotes	portions
T4445	5581-5583	IN	denotes	of
T4446	5584-5588	DT	denotes	each
T4447	5589-5599	NN	denotes	chromosome
T4448	5600-5608	JJ	denotes	unpaired
T4449	5608-5609	.	denotes	.
T4450	5609-5762	sentence	denotes	In eutherian and marsupial mammals, these unpaired chromosome regions are associated with a specialized chromatin domain termed the XY body or sex body.
T4451	5610-5612	IN	denotes	In
T4452	5684-5694	VBN	denotes	associated
T4453	5613-5622	JJ	denotes	eutherian
T4454	5637-5644	NNS	denotes	mammals
T4455	5623-5626	CC	denotes	and
T4456	5627-5636	JJ	denotes	marsupial
T4457	5644-5646	,	denotes	,
T4458	5646-5651	DT	denotes	these
T4459	5672-5679	NNS	denotes	regions
T4460	5652-5660	JJ	denotes	unpaired
T4461	5661-5671	NN	denotes	chromosome
T4462	5680-5683	VBP	denotes	are
T4463	5695-5699	IN	denotes	with
T4464	5700-5701	DT	denotes	a
T4465	5724-5730	NN	denotes	domain
T4466	5702-5713	VBN	denotes	specialized
T4467	5714-5723	NN	denotes	chromatin
T4468	5731-5737	VBN	denotes	termed
T4469	5738-5741	DT	denotes	the
T4470	5745-5749	NN	denotes	body
T4471	5742-5744	NN	denotes	XY
T4472	5750-5752	CC	denotes	or
T4473	5753-5756	NN	denotes	sex
T4474	5757-5761	NN	denotes	body
T4475	5761-5762	.	denotes	.
T4476	5762-5889	sentence	denotes	The function of the XY body is uncertain [7–11], but there is evidence that it is essential for male meiotic progression [12].
T4477	5763-5766	DT	denotes	The
T4478	5767-5775	NN	denotes	function
T4479	5791-5793	VBZ	denotes	is
T4480	5776-5778	IN	denotes	of
T4481	5779-5782	DT	denotes	the
T4482	5786-5790	NN	denotes	body
T4483	5783-5785	NN	denotes	XY
T4484	5794-5803	JJ	denotes	uncertain
T4485	5804-5805	-LRB-	denotes	[
T4486	5805-5806	CD	denotes	7
T4487	5806-5807	SYM	denotes	–
T4488	5807-5809	CD	denotes	11
T4489	5809-5810	-RRB-	denotes	]
T4490	5810-5812	,	denotes	,
T4491	5812-5815	CC	denotes	but
T4492	5816-5821	EX	denotes	there
T4493	5822-5824	VBZ	denotes	is
T4494	5825-5833	NN	denotes	evidence
T4495	5834-5838	IN	denotes	that
T4496	5842-5844	VBZ	denotes	is
T4497	5839-5841	PRP	denotes	it
T4498	5845-5854	JJ	denotes	essential
T4499	5855-5858	IN	denotes	for
T4500	5859-5863	JJ	denotes	male
T4501	5872-5883	NN	denotes	progression
T4502	5864-5871	JJ	denotes	meiotic
T4503	5884-5885	-LRB-	denotes	[
T4504	5885-5887	CD	denotes	12
T4505	5887-5888	-RRB-	denotes	]
T4506	5888-5889	.	denotes	.
T4507	5889-6093	sentence	denotes	Several proteins are reported to localize to the XY body, including BRCA1, ATR, the histone variant H3.3, and modified histones such as ubiquitinated H2A (Ub-H2A) and phosphorylated H2AX (γH2AX) [12–15].
T4508	5890-5897	JJ	denotes	Several
T4509	5898-5906	NN	denotes	proteins
T4510	5911-5919	VBN	denotes	reported
T4511	5907-5910	VBP	denotes	are
T4512	5920-5922	TO	denotes	to
T4513	5923-5931	VB	denotes	localize
T4514	5932-5934	IN	denotes	to
T4515	5935-5938	DT	denotes	the
T4516	5942-5946	NN	denotes	body
T4517	5939-5941	NN	denotes	XY
T4518	5946-5948	,	denotes	,
T4519	5948-5957	VBG	denotes	including
T4520	5958-5963	NN	denotes	BRCA1
T4521	5963-5965	,	denotes	,
T4522	5965-5968	NN	denotes	ATR
T4523	5968-5970	,	denotes	,
T4524	5970-5973	DT	denotes	the
T4525	5990-5994	NN	denotes	H3.3
T4526	5974-5981	NN	denotes	histone
T4527	5982-5989	NN	denotes	variant
T4528	5994-5996	,	denotes	,
T4529	5996-5999	CC	denotes	and
T4530	6000-6008	VBN	denotes	modified
T4531	6009-6017	NNS	denotes	histones
T4532	6018-6022	JJ	denotes	such
T4533	6023-6025	IN	denotes	as
T4534	6026-6039	VBN	denotes	ubiquitinated
T4535	6040-6043	NN	denotes	H2A
T4536	6044-6045	-LRB-	denotes	(
T4537	6045-6047	NN	denotes	Ub
T4538	6048-6051	NN	denotes	H2A
T4539	6047-6048	HYPH	denotes	-
T4540	6051-6052	-RRB-	denotes	)
T4541	6053-6056	CC	denotes	and
T4542	6057-6071	VBN	denotes	phosphorylated
T4543	6072-6076	NN	denotes	H2AX
T4544	6077-6078	-LRB-	denotes	(
T4545	6078-6083	NN	denotes	γH2AX
T4546	6083-6084	-RRB-	denotes	)
T4547	6085-6086	-LRB-	denotes	[
T4548	6086-6088	CD	denotes	12
T4549	6088-6089	SYM	denotes	–
T4550	6089-6091	CD	denotes	15
T4551	6091-6092	-RRB-	denotes	]
T4552	6092-6093	.	denotes	.
T4553	6093-6224	sentence	denotes	In the XY body, the sex chromosomes are transcriptionally silenced in a process termed meiotic sex chromosome inactivation (MSCI).
T4554	6094-6096	IN	denotes	In
T4555	6152-6160	VBN	denotes	silenced
T4556	6097-6100	DT	denotes	the
T4557	6104-6108	NN	denotes	body
T4558	6101-6103	NN	denotes	XY
T4559	6108-6110	,	denotes	,
T4560	6110-6113	DT	denotes	the
T4561	6118-6129	NNS	denotes	chromosomes
T4562	6114-6117	NN	denotes	sex
T4563	6130-6133	VBP	denotes	are
T4564	6134-6151	RB	denotes	transcriptionally
T4565	6161-6163	IN	denotes	in
T4566	6164-6165	DT	denotes	a
T4567	6166-6173	NN	denotes	process
T4568	6174-6180	VBN	denotes	termed
T4569	6181-6188	JJ	denotes	meiotic
T4570	6204-6216	NN	denotes	inactivation
T4571	6189-6192	NN	denotes	sex
T4572	6193-6203	NN	denotes	chromosome
T4573	6217-6218	-LRB-	denotes	(
T4574	6218-6222	NN	denotes	MSCI
T4575	6222-6223	-RRB-	denotes	)
T4576	6223-6224	.	denotes	.
T4577	6224-6353	sentence	denotes	The XY body disappears after pachynema; however, many sex-linked genes remain transcriptionally silent into spermiogenesis [16].
T4578	6225-6228	DT	denotes	The
T4579	6232-6236	NN	denotes	body
T4580	6229-6231	NN	denotes	XY
T4581	6237-6247	VBZ	denotes	disappears
T4582	6296-6302	VBP	denotes	remain
T4583	6248-6253	IN	denotes	after
T4584	6254-6263	NN	denotes	pachynema
T4585	6263-6264	:	denotes	;
T4586	6265-6272	RB	denotes	however
T4587	6272-6274	,	denotes	,
T4588	6274-6278	JJ	denotes	many
T4589	6290-6295	NNS	denotes	genes
T4590	6279-6282	NN	denotes	sex
T4591	6283-6289	VBN	denotes	linked
T4592	6282-6283	HYPH	denotes	-
T4593	6303-6320	RB	denotes	transcriptionally
T4594	6321-6327	JJ	denotes	silent
T4595	6328-6332	IN	denotes	into
T4596	6333-6347	NN	denotes	spermiogenesis
T4597	6348-6349	-LRB-	denotes	[
T4598	6349-6351	CD	denotes	16
T4599	6351-6352	-RRB-	denotes	]
T4600	6352-6353	.	denotes	.
T4601	6353-6520	sentence	denotes	This maintenance of silencing is associated with a distinct set of chromatin marks that define a sex chromatin domain termed postmeiotic sex chromatin (PMSC) [16,17].
T4602	6354-6358	DT	denotes	This
T4603	6359-6370	NN	denotes	maintenance
T4604	6387-6397	VBN	denotes	associated
T4605	6371-6373	IN	denotes	of
T4606	6374-6383	NN	denotes	silencing
T4607	6384-6386	VBZ	denotes	is
T4608	6398-6402	IN	denotes	with
T4609	6403-6404	DT	denotes	a
T4610	6414-6417	NN	denotes	set
T4611	6405-6413	JJ	denotes	distinct
T4612	6418-6420	IN	denotes	of
T4613	6421-6430	NN	denotes	chromatin
T4614	6431-6436	NNS	denotes	marks
T4615	6437-6441	WDT	denotes	that
T4616	6442-6448	VBP	denotes	define
T4617	6449-6450	DT	denotes	a
T4618	6465-6471	NN	denotes	domain
T4619	6451-6454	NN	denotes	sex
T4620	6455-6464	NN	denotes	chromatin
T4621	6472-6478	VBN	denotes	termed
T4622	6479-6490	JJ	denotes	postmeiotic
T4623	6495-6504	NN	denotes	chromatin
T4624	6491-6494	NN	denotes	sex
T4625	6505-6506	-LRB-	denotes	(
T4626	6506-6510	NN	denotes	PMSC
T4627	6510-6511	-RRB-	denotes	)
T4628	6512-6513	-LRB-	denotes	[
T4629	6516-6518	CD	denotes	17
T4630	6513-6515	CD	denotes	16
T4631	6515-6516	,	denotes	,
T4632	6518-6519	-RRB-	denotes	]
T4633	6519-6520	.	denotes	.
T4634	6520-6816	sentence	denotes	Regulators of sexual differentiation have been identified in a number of organisms, but in contrast to many other developmental processes, such as axial patterning or development of many body parts, the molecular mechanisms that regulate sexual differentiation are highly variable between phyla.
T4635	6521-6531	NNS	denotes	Regulators
T4636	6568-6578	VBN	denotes	identified
T4637	6532-6534	IN	denotes	of
T4638	6535-6541	JJ	denotes	sexual
T4639	6542-6557	NN	denotes	differentiation
T4640	6558-6562	VBP	denotes	have
T4641	6563-6567	VBN	denotes	been
T4642	6579-6581	IN	denotes	in
T4643	6582-6583	DT	denotes	a
T4644	6584-6590	NN	denotes	number
T4645	6591-6593	IN	denotes	of
T4646	6594-6603	NNS	denotes	organisms
T4647	6603-6605	,	denotes	,
T4648	6605-6608	CC	denotes	but
T4649	6609-6611	IN	denotes	in
T4650	6782-6785	VBP	denotes	are
T4651	6612-6620	NN	denotes	contrast
T4652	6621-6623	IN	denotes	to
T4653	6624-6628	JJ	denotes	many
T4654	6649-6658	NNS	denotes	processes
T4655	6629-6634	JJ	denotes	other
T4656	6635-6648	JJ	denotes	developmental
T4657	6658-6660	,	denotes	,
T4658	6660-6664	JJ	denotes	such
T4659	6665-6667	IN	denotes	as
T4660	6668-6673	JJ	denotes	axial
T4661	6674-6684	NN	denotes	patterning
T4662	6685-6687	CC	denotes	or
T4663	6688-6699	NN	denotes	development
T4664	6700-6702	IN	denotes	of
T4665	6703-6707	JJ	denotes	many
T4666	6713-6718	NNS	denotes	parts
T4667	6708-6712	NN	denotes	body
T4668	6718-6720	,	denotes	,
T4669	6720-6723	DT	denotes	the
T4670	6734-6744	NNS	denotes	mechanisms
T4671	6724-6733	JJ	denotes	molecular
T4672	6745-6749	WDT	denotes	that
T4673	6750-6758	VBP	denotes	regulate
T4674	6759-6765	JJ	denotes	sexual
T4675	6766-6781	NN	denotes	differentiation
T4676	6786-6792	RB	denotes	highly
T4677	6793-6801	JJ	denotes	variable
T4678	6802-6809	IN	denotes	between
T4679	6810-6815	NNS	denotes	phyla
T4680	6815-6816	.	denotes	.
T4681	6816-6971	sentence	denotes	A notable exception involves genes related to doublesex (dsx) of Drosophila, which share a Doublesex/MAB-3 DNA-binding motif called the DM domain [18,19].
T4682	6817-6818	DT	denotes	A
T4683	6827-6836	NN	denotes	exception
T4684	6819-6826	JJ	denotes	notable
T4685	6837-6845	VBZ	denotes	involves
T4686	6846-6851	NNS	denotes	genes
T4687	6852-6859	VBN	denotes	related
T4688	6860-6862	IN	denotes	to
T4689	6863-6872	NN	denotes	doublesex
T4690	6873-6874	-LRB-	denotes	(
T4691	6874-6877	NN	denotes	dsx
T4692	6877-6878	-RRB-	denotes	)
T4693	6879-6881	IN	denotes	of
T4694	6882-6892	NNP	denotes	Drosophila
T4695	6892-6894	,	denotes	,
T4696	6894-6899	WDT	denotes	which
T4697	6900-6905	VBP	denotes	share
T4698	6906-6907	DT	denotes	a
T4699	6936-6941	NN	denotes	motif
T4700	6908-6917	NN	denotes	Doublesex
T4701	6918-6921	NN	denotes	MAB
T4702	6917-6918	HYPH	denotes	/
T4703	6921-6922	HYPH	denotes	-
T4704	6922-6923	CD	denotes	3
T4705	6924-6927	NN	denotes	DNA
T4706	6927-6928	HYPH	denotes	-
T4707	6928-6935	VBG	denotes	binding
T4708	6942-6948	VBN	denotes	called
T4709	6949-6952	DT	denotes	the
T4710	6956-6962	NN	denotes	domain
T4711	6953-6955	NN	denotes	DM
T4712	6963-6964	-LRB-	denotes	[
T4713	6967-6969	CD	denotes	19
T4714	6964-6966	CD	denotes	18
T4715	6966-6967	,	denotes	,
T4716	6969-6970	-RRB-	denotes	]
T4717	6970-6971	.	denotes	.
T4718	6971-7107	sentence	denotes	DM domain–encoding genes have been shown to regulate various aspects of sexual differentiation in insects, nematodes, and mammals [20].
T4719	6972-6974	NN	denotes	DM
T4720	6991-6996	NNS	denotes	genes
T4721	6975-6981	NN	denotes	domain
T4722	6982-6990	VBG	denotes	encoding
T4723	6981-6982	HYPH	denotes	–
T4724	7007-7012	VBN	denotes	shown
T4725	6997-7001	VBP	denotes	have
T4726	7002-7006	VBN	denotes	been
T4727	7013-7015	TO	denotes	to
T4728	7016-7024	VB	denotes	regulate
T4729	7025-7032	JJ	denotes	various
T4730	7033-7040	NNS	denotes	aspects
T4731	7041-7043	IN	denotes	of
T4732	7044-7050	JJ	denotes	sexual
T4733	7051-7066	NN	denotes	differentiation
T4734	7067-7069	IN	denotes	in
T4735	7070-7077	NNS	denotes	insects
T4736	7077-7079	,	denotes	,
T4737	7079-7088	NNS	denotes	nematodes
T4738	7088-7090	,	denotes	,
T4739	7090-7093	CC	denotes	and
T4740	7094-7101	NNS	denotes	mammals
T4741	7102-7103	-LRB-	denotes	[
T4742	7103-7105	CD	denotes	20
T4743	7105-7106	-RRB-	denotes	]
T4744	7106-7107	.	denotes	.
T4745	7107-7419	sentence	denotes	The mab-3 gene of Caenorhabditis elegans has been shown to function analogously to DSX in several respects and can be functionally replaced by the male isoform of DSX, suggesting that the similarity in the sequence of these genes may stem from conservation of an ancestral DM domain sexual regulator [18,21,22].
T4746	7108-7111	DT	denotes	The
T4747	7118-7122	NN	denotes	gene
T4748	7112-7115	NN	denotes	mab
T4749	7115-7116	HYPH	denotes	-
T4750	7116-7117	CD	denotes	3
T4751	7158-7163	VBN	denotes	shown
T4752	7123-7125	IN	denotes	of
T4753	7126-7140	NNP	denotes	Caenorhabditis
T4754	7141-7148	NNP	denotes	elegans
T4755	7149-7152	VBZ	denotes	has
T4756	7153-7157	VBN	denotes	been
T4757	7164-7166	TO	denotes	to
T4758	7167-7175	VB	denotes	function
T4759	7176-7187	RB	denotes	analogously
T4760	7188-7190	IN	denotes	to
T4761	7191-7194	NN	denotes	DSX
T4762	7195-7197	IN	denotes	in
T4763	7198-7205	JJ	denotes	several
T4764	7206-7214	NNS	denotes	respects
T4765	7215-7218	CC	denotes	and
T4766	7219-7222	MD	denotes	can
T4767	7239-7247	VBN	denotes	replaced
T4768	7223-7225	VB	denotes	be
T4769	7226-7238	RB	denotes	functionally
T4770	7248-7250	IN	denotes	by
T4771	7251-7254	DT	denotes	the
T4772	7260-7267	NN	denotes	isoform
T4773	7255-7259	JJ	denotes	male
T4774	7268-7270	IN	denotes	of
T4775	7271-7274	NN	denotes	DSX
T4776	7274-7276	,	denotes	,
T4777	7276-7286	VBG	denotes	suggesting
T4778	7287-7291	IN	denotes	that
T4779	7342-7346	VB	denotes	stem
T4780	7292-7295	DT	denotes	the
T4781	7296-7306	NN	denotes	similarity
T4782	7307-7309	IN	denotes	in
T4783	7310-7313	DT	denotes	the
T4784	7314-7322	NN	denotes	sequence
T4785	7323-7325	IN	denotes	of
T4786	7326-7331	DT	denotes	these
T4787	7332-7337	NNS	denotes	genes
T4788	7338-7341	MD	denotes	may
T4789	7347-7351	IN	denotes	from
T4790	7352-7364	NN	denotes	conservation
T4791	7365-7367	IN	denotes	of
T4792	7368-7370	DT	denotes	an
T4793	7398-7407	NN	denotes	regulator
T4794	7371-7380	JJ	denotes	ancestral
T4795	7381-7383	NN	denotes	DM
T4796	7384-7390	NN	denotes	domain
T4797	7391-7397	JJ	denotes	sexual
T4798	7408-7409	-LRB-	denotes	[
T4799	7415-7417	CD	denotes	22
T4800	7409-7411	CD	denotes	18
T4801	7411-7412	,	denotes	,
T4802	7412-7414	CD	denotes	21
T4803	7414-7415	,	denotes	,
T4804	7417-7418	-RRB-	denotes	]
T4805	7418-7419	.	denotes	.
T4806	7419-7562	sentence	denotes	Vertebrates also have DM domain genes, and analysis to date, although limited, has shown that these genes also control sexual differentiation.
T4807	7420-7431	NNS	denotes	Vertebrates
T4808	7437-7441	VBP	denotes	have
T4809	7432-7436	RB	denotes	also
T4810	7442-7444	NN	denotes	DM
T4811	7445-7451	NN	denotes	domain
T4812	7452-7457	NNS	denotes	genes
T4813	7457-7459	,	denotes	,
T4814	7459-7462	CC	denotes	and
T4815	7463-7471	NN	denotes	analysis
T4816	7503-7508	VBN	denotes	shown
T4817	7472-7474	IN	denotes	to
T4818	7475-7479	NN	denotes	date
T4819	7479-7481	,	denotes	,
T4820	7481-7489	IN	denotes	although
T4821	7490-7497	JJ	denotes	limited
T4822	7497-7499	,	denotes	,
T4823	7499-7502	VBZ	denotes	has
T4824	7509-7513	IN	denotes	that
T4825	7531-7538	VBP	denotes	control
T4826	7514-7519	DT	denotes	these
T4827	7520-7525	NNS	denotes	genes
T4828	7526-7530	RB	denotes	also
T4829	7539-7545	JJ	denotes	sexual
T4830	7546-7561	NN	denotes	differentiation
T4831	7561-7562	.	denotes	.
T4832	7562-7680	sentence	denotes	Mammals have seven DM domain genes (Dmrt genes), several of which exhibit sexually dimorphic mRNA expression [23,24].
T4833	7563-7570	NNS	denotes	Mammals
T4834	7571-7575	VBP	denotes	have
T4835	7576-7581	CD	denotes	seven
T4836	7592-7597	NNS	denotes	genes
T4837	7582-7584	NN	denotes	DM
T4838	7585-7591	NN	denotes	domain
T4839	7598-7599	-LRB-	denotes	(
T4840	7604-7609	NNS	denotes	genes
T4841	7599-7603	NN	denotes	Dmrt
T4842	7609-7610	-RRB-	denotes	)
T4843	7610-7612	,	denotes	,
T4844	7612-7619	JJ	denotes	several
T4845	7629-7636	VBP	denotes	exhibit
T4846	7620-7622	IN	denotes	of
T4847	7623-7628	WDT	denotes	which
T4848	7637-7645	RB	denotes	sexually
T4849	7646-7655	JJ	denotes	dimorphic
T4850	7661-7671	NN	denotes	expression
T4851	7656-7660	NN	denotes	mRNA
T4852	7672-7673	-LRB-	denotes	[
T4853	7676-7678	CD	denotes	24
T4854	7673-7675	CD	denotes	23
T4855	7675-7676	,	denotes	,
T4856	7678-7679	-RRB-	denotes	]
T4857	7679-7680	.	denotes	.
T4858	7680-7947	sentence	denotes	The best studied of these genes, Dmrt1, is expressed in the differentiating male genital ridges and adult testis of mammals, birds, fish, and reptiles, and a recently duplicated Dmrt1 gene functions as the Y-linked testis-determining gene in the Medaka fish [25–29].
T4859	7681-7684	DT	denotes	The
T4860	7690-7697	VBN	denotes	studied
T4861	7685-7689	RBS	denotes	best
T4862	7724-7733	VBN	denotes	expressed
T4863	7698-7700	IN	denotes	of
T4864	7701-7706	DT	denotes	these
T4865	7707-7712	NNS	denotes	genes
T4866	7712-7714	,	denotes	,
T4867	7714-7719	NN	denotes	Dmrt1
T4868	7719-7721	,	denotes	,
T4869	7721-7723	VBZ	denotes	is
T4870	7734-7736	IN	denotes	in
T4871	7737-7740	DT	denotes	the
T4872	7770-7776	NNS	denotes	ridges
T4873	7741-7756	VBG	denotes	differentiating
T4874	7757-7761	JJ	denotes	male
T4875	7762-7769	JJ	denotes	genital
T4876	7777-7780	CC	denotes	and
T4877	7781-7786	JJ	denotes	adult
T4878	7787-7793	NN	denotes	testis
T4879	7794-7796	IN	denotes	of
T4880	7797-7804	NNS	denotes	mammals
T4881	7804-7806	,	denotes	,
T4882	7806-7811	NNS	denotes	birds
T4883	7811-7813	,	denotes	,
T4884	7813-7817	NNS	denotes	fish
T4885	7817-7819	,	denotes	,
T4886	7819-7822	CC	denotes	and
T4887	7823-7831	NNS	denotes	reptiles
T4888	7831-7833	,	denotes	,
T4889	7833-7836	CC	denotes	and
T4890	7837-7838	DT	denotes	a
T4891	7865-7869	NN	denotes	gene
T4892	7839-7847	RB	denotes	recently
T4893	7848-7858	VBN	denotes	duplicated
T4894	7859-7864	NN	denotes	Dmrt1
T4895	7870-7879	VBZ	denotes	functions
T4896	7880-7882	IN	denotes	as
T4897	7883-7886	DT	denotes	the
T4898	7915-7919	NN	denotes	gene
T4899	7887-7888	NN	denotes	Y
T4900	7889-7895	VBN	denotes	linked
T4901	7888-7889	HYPH	denotes	-
T4902	7896-7902	NN	denotes	testis
T4903	7903-7914	VBG	denotes	determining
T4904	7902-7903	HYPH	denotes	-
T4905	7920-7922	IN	denotes	in
T4906	7923-7926	DT	denotes	the
T4907	7934-7938	NN	denotes	fish
T4908	7927-7933	NNP	denotes	Medaka
T4909	7939-7940	-LRB-	denotes	[
T4910	7940-7942	CD	denotes	25
T4911	7942-7943	SYM	denotes	–
T4912	7943-7945	CD	denotes	29
T4913	7945-7946	-RRB-	denotes	]
T4914	7946-7947	.	denotes	.
T4915	7947-8100	sentence	denotes	Human DMRT1 maps to an autosomal locus, which, when hemizygous, is associated with defective testicular development and consequent XY feminization [30].
T4916	7948-7953	JJ	denotes	Human
T4917	7954-7959	NN	denotes	DMRT1
T4918	7960-7964	VBZ	denotes	maps
T4919	7965-7967	IN	denotes	to
T4920	7968-7970	DT	denotes	an
T4921	7981-7986	NN	denotes	locus
T4922	7971-7980	JJ	denotes	autosomal
T4923	7986-7988	,	denotes	,
T4924	7988-7993	WDT	denotes	which
T4925	8015-8025	VBN	denotes	associated
T4926	7993-7995	,	denotes	,
T4927	7995-7999	WRB	denotes	when
T4928	8000-8010	JJ	denotes	hemizygous
T4929	8010-8012	,	denotes	,
T4930	8012-8014	VBZ	denotes	is
T4931	8026-8030	IN	denotes	with
T4932	8031-8040	JJ	denotes	defective
T4933	8052-8063	NN	denotes	development
T4934	8041-8051	JJ	denotes	testicular
T4935	8064-8067	CC	denotes	and
T4936	8068-8078	JJ	denotes	consequent
T4937	8082-8094	NN	denotes	feminization
T4938	8079-8081	NN	denotes	XY
T4939	8095-8096	-LRB-	denotes	[
T4940	8096-8098	CD	denotes	30
T4941	8098-8099	-RRB-	denotes	]
T4942	8099-8100	.	denotes	.
T4943	8100-8252	sentence	denotes	Similarly, mice homozygous for a null mutation in Dmrt1 have severe defects in testis differentiation involving both germ cells and Sertoli cells [31].
T4944	8101-8110	RB	denotes	Similarly
T4945	8157-8161	VBP	denotes	have
T4946	8110-8112	,	denotes	,
T4947	8112-8116	NNS	denotes	mice
T4948	8117-8127	JJ	denotes	homozygous
T4949	8128-8131	IN	denotes	for
T4950	8132-8133	DT	denotes	a
T4951	8139-8147	NN	denotes	mutation
T4952	8134-8138	JJ	denotes	null
T4953	8148-8150	IN	denotes	in
T4954	8151-8156	NN	denotes	Dmrt1
T4955	8162-8168	JJ	denotes	severe
T4956	8169-8176	NNS	denotes	defects
T4957	8177-8179	IN	denotes	in
T4958	8180-8186	NN	denotes	testis
T4959	8187-8202	NN	denotes	differentiation
T4960	8203-8212	VBG	denotes	involving
T4961	8213-8217	CC	denotes	both
T4962	8223-8228	NNS	denotes	cells
T4963	8218-8222	NN	denotes	germ
T4964	8229-8232	CC	denotes	and
T4965	8233-8240	NN	denotes	Sertoli
T4966	8241-8246	NNS	denotes	cells
T4967	8247-8248	-LRB-	denotes	[
T4968	8248-8250	CD	denotes	31
T4969	8250-8251	-RRB-	denotes	]
T4970	8251-8252	.	denotes	.
T4971	8252-8380	sentence	denotes	Female mice mutant in Dmrt4 have polyovular follicles, indicating that this gene also plays a role in gonadal development [32].
T4972	8253-8259	JJ	denotes	Female
T4973	8260-8264	NNS	denotes	mice
T4974	8281-8285	VBP	denotes	have
T4975	8265-8271	JJ	denotes	mutant
T4976	8272-8274	IN	denotes	in
T4977	8275-8280	NN	denotes	Dmrt4
T4978	8286-8296	JJ	denotes	polyovular
T4979	8297-8306	NNS	denotes	follicles
T4980	8306-8308	,	denotes	,
T4981	8308-8318	VBG	denotes	indicating
T4982	8319-8323	IN	denotes	that
T4983	8339-8344	VBZ	denotes	plays
T4984	8324-8328	DT	denotes	this
T4985	8329-8333	NN	denotes	gene
T4986	8334-8338	RB	denotes	also
T4987	8345-8346	DT	denotes	a
T4988	8347-8351	NN	denotes	role
T4989	8352-8354	IN	denotes	in
T4990	8355-8362	JJ	denotes	gonadal
T4991	8363-8374	NN	denotes	development
T4992	8375-8376	-LRB-	denotes	[
T4993	8376-8378	CD	denotes	32
T4994	8378-8379	-RRB-	denotes	]
T4995	8379-8380	.	denotes	.
T4996	8380-8502	sentence	denotes	It appears from these studies that the involvement of DM domain genes in sexual differentiation is ancient and conserved.
T4997	8381-8383	PRP	denotes	It
T4998	8384-8391	VBZ	denotes	appears
T4999	8392-8396	IN	denotes	from
T5000	8397-8402	DT	denotes	these
T5001	8403-8410	NNS	denotes	studies
T5002	8411-8415	IN	denotes	that
T5003	8477-8479	VBZ	denotes	is
T5004	8416-8419	DT	denotes	the
T5005	8420-8431	NN	denotes	involvement
T5006	8432-8434	IN	denotes	of
T5007	8435-8437	NN	denotes	DM
T5008	8438-8444	NN	denotes	domain
T5009	8445-8450	NNS	denotes	genes
T5010	8451-8453	IN	denotes	in
T5011	8454-8460	JJ	denotes	sexual
T5012	8461-8476	NN	denotes	differentiation
T5013	8480-8487	JJ	denotes	ancient
T5014	8488-8491	CC	denotes	and
T5015	8492-8501	JJ	denotes	conserved
T5016	8501-8502	.	denotes	.
T5017	8502-8658	sentence	denotes	However, vertebrate Dmrt gene function is not limited to sexual differentiation: Dmrt2 is required in both sexes for segmentation in mice and fish [33–35].
T5018	8503-8510	RB	denotes	However
T5019	8542-8544	VBZ	denotes	is
T5020	8510-8512	,	denotes	,
T5021	8512-8522	NN	denotes	vertebrate
T5022	8533-8541	NN	denotes	function
T5023	8523-8527	NN	denotes	Dmrt
T5024	8528-8532	NN	denotes	gene
T5025	8593-8601	VBN	denotes	required
T5026	8545-8548	RB	denotes	not
T5027	8549-8556	JJ	denotes	limited
T5028	8557-8559	IN	denotes	to
T5029	8560-8566	JJ	denotes	sexual
T5030	8567-8582	NN	denotes	differentiation
T5031	8582-8584	:	denotes	:
T5032	8584-8589	NN	denotes	Dmrt2
T5033	8590-8592	VBZ	denotes	is
T5034	8602-8604	IN	denotes	in
T5035	8605-8609	DT	denotes	both
T5036	8610-8615	NNS	denotes	sexes
T5037	8616-8619	IN	denotes	for
T5038	8620-8632	NN	denotes	segmentation
T5039	8633-8635	IN	denotes	in
T5040	8636-8640	NNS	denotes	mice
T5041	8641-8644	CC	denotes	and
T5042	8645-8649	NNS	denotes	fish
T5043	8650-8651	-LRB-	denotes	[
T5044	8651-8653	CD	denotes	33
T5045	8653-8654	SYM	denotes	–
T5046	8654-8656	CD	denotes	35
T5047	8656-8657	-RRB-	denotes	]
T5048	8657-8658	.	denotes	.
T5049	8658-8745	sentence	denotes	Here, we have investigated the expression and function of the Dmrt7 gene in the mouse.
T5050	8659-8663	RB	denotes	Here
T5051	8673-8685	VBN	denotes	investigated
T5052	8663-8665	,	denotes	,
T5053	8665-8667	PRP	denotes	we
T5054	8668-8672	VBP	denotes	have
T5055	8686-8689	DT	denotes	the
T5056	8690-8700	NN	denotes	expression
T5057	8701-8704	CC	denotes	and
T5058	8705-8713	NN	denotes	function
T5059	8714-8716	IN	denotes	of
T5060	8717-8720	DT	denotes	the
T5061	8727-8731	NN	denotes	gene
T5062	8721-8726	NN	denotes	Dmrt7
T5063	8732-8734	IN	denotes	in
T5064	8735-8738	DT	denotes	the
T5065	8739-8744	NN	denotes	mouse
T5066	8744-8745	.	denotes	.
T5067	8745-8907	sentence	denotes	Dmrt7 is expressed only in the gonad, and, unlike the other Dmrt genes, appears to be present exclusively in mammals and not in nonmammalian vertebrates [23,36].
T5068	8746-8751	NN	denotes	Dmrt7
T5069	8755-8764	VBN	denotes	expressed
T5070	8752-8754	VBZ	denotes	is
T5071	8765-8769	RB	denotes	only
T5072	8770-8772	IN	denotes	in
T5073	8773-8776	DT	denotes	the
T5074	8777-8782	NN	denotes	gonad
T5075	8782-8784	,	denotes	,
T5076	8784-8787	CC	denotes	and
T5077	8787-8789	,	denotes	,
T5078	8789-8795	IN	denotes	unlike
T5079	8818-8825	VBZ	denotes	appears
T5080	8796-8799	DT	denotes	the
T5081	8811-8816	NNS	denotes	genes
T5082	8800-8805	JJ	denotes	other
T5083	8806-8810	NN	denotes	Dmrt
T5084	8816-8818	,	denotes	,
T5085	8826-8828	TO	denotes	to
T5086	8829-8831	VB	denotes	be
T5087	8832-8839	JJ	denotes	present
T5088	8840-8851	RB	denotes	exclusively
T5089	8852-8854	IN	denotes	in
T5090	8855-8862	NNS	denotes	mammals
T5091	8863-8866	CC	denotes	and
T5092	8867-8870	RB	denotes	not
T5093	8871-8873	IN	denotes	in
T5094	8874-8886	JJ	denotes	nonmammalian
T5095	8887-8898	NNS	denotes	vertebrates
T5096	8899-8900	-LRB-	denotes	[
T5097	8903-8905	CD	denotes	36
T5098	8900-8902	CD	denotes	23
T5099	8902-8903	,	denotes	,
T5100	8905-8906	-RRB-	denotes	]
T5101	8906-8907	.	denotes	.
T5102	8907-9040	sentence	denotes	We find that DMRT7 protein is expressed only in germ cells and is selectively localized to the XY body of male pachytene germ cells.
T5103	8908-8910	PRP	denotes	We
T5104	8911-8915	VBP	denotes	find
T5105	8916-8920	IN	denotes	that
T5106	8938-8947	VBN	denotes	expressed
T5107	8921-8926	NN	denotes	DMRT7
T5108	8927-8934	NN	denotes	protein
T5109	8935-8937	VBZ	denotes	is
T5110	8948-8952	RB	denotes	only
T5111	8953-8955	IN	denotes	in
T5112	8956-8960	NN	denotes	germ
T5113	8961-8966	NNS	denotes	cells
T5114	8967-8970	CC	denotes	and
T5115	8971-8973	VBZ	denotes	is
T5116	8986-8995	VBN	denotes	localized
T5117	8974-8985	RB	denotes	selectively
T5118	8996-8998	IN	denotes	to
T5119	8999-9002	DT	denotes	the
T5120	9006-9010	NN	denotes	body
T5121	9003-9005	NN	denotes	XY
T5122	9011-9013	IN	denotes	of
T5123	9014-9018	JJ	denotes	male
T5124	9034-9039	NNS	denotes	cells
T5125	9019-9028	NN	denotes	pachytene
T5126	9029-9033	NN	denotes	germ
T5127	9039-9040	.	denotes	.
T5128	9040-9126	sentence	denotes	To test its function, we generated a conditional null mutation of Dmrt7 in the mouse.
T5129	9041-9043	TO	denotes	To
T5130	9044-9048	VB	denotes	test
T5131	9066-9075	VBD	denotes	generated
T5132	9049-9052	PRP$	denotes	its
T5133	9053-9061	NN	denotes	function
T5134	9061-9063	,	denotes	,
T5135	9063-9065	PRP	denotes	we
T5136	9076-9077	DT	denotes	a
T5137	9095-9103	NN	denotes	mutation
T5138	9078-9089	JJ	denotes	conditional
T5139	9090-9094	JJ	denotes	null
T5140	9104-9106	IN	denotes	of
T5141	9107-9112	NN	denotes	Dmrt7
T5142	9113-9115	IN	denotes	in
T5143	9116-9119	DT	denotes	the
T5144	9120-9125	NN	denotes	mouse
T5145	9125-9126	.	denotes	.
T5146	9126-9261	sentence	denotes	We find that Dmrt7 is required in males for progression beyond the pachytene stage of meiotic prophase but is not required in females.
T5147	9127-9129	PRP	denotes	We
T5148	9130-9134	VBP	denotes	find
T5149	9135-9139	IN	denotes	that
T5150	9149-9157	VBN	denotes	required
T5151	9140-9145	NN	denotes	Dmrt7
T5152	9146-9148	VBZ	denotes	is
T5153	9158-9160	IN	denotes	in
T5154	9161-9166	NNS	denotes	males
T5155	9167-9170	IN	denotes	for
T5156	9171-9182	NN	denotes	progression
T5157	9183-9189	IN	denotes	beyond
T5158	9190-9193	DT	denotes	the
T5159	9204-9209	NN	denotes	stage
T5160	9194-9203	NN	denotes	pachytene
T5161	9210-9212	IN	denotes	of
T5162	9213-9220	JJ	denotes	meiotic
T5163	9221-9229	NN	denotes	prophase
T5164	9230-9233	CC	denotes	but
T5165	9234-9236	VBZ	denotes	is
T5166	9241-9249	VBN	denotes	required
T5167	9237-9240	RB	denotes	not
T5168	9250-9252	IN	denotes	in
T5169	9253-9260	NNS	denotes	females
T5170	9260-9261	.	denotes	.
T5171	9261-9350	sentence	denotes	In rare mutant cells that survive to diplonema, we observed sex chromatin abnormalities.
T5172	9262-9264	IN	denotes	In
T5173	9313-9321	VBD	denotes	observed
T5174	9265-9269	JJ	denotes	rare
T5175	9277-9282	NNS	denotes	cells
T5176	9270-9276	NN	denotes	mutant
T5177	9283-9287	WDT	denotes	that
T5178	9288-9295	VBP	denotes	survive
T5179	9296-9298	IN	denotes	to
T5180	9299-9308	NN	denotes	diplonema
T5181	9308-9310	,	denotes	,
T5182	9310-9312	PRP	denotes	we
T5183	9322-9325	NN	denotes	sex
T5184	9326-9335	NN	denotes	chromatin
T5185	9336-9349	NNS	denotes	abnormalities
T5186	9349-9350	.	denotes	.
T5187	9350-9520	sentence	denotes	Based on these observations, we suggest that Dmrt7 plays a critical role in a male-specific chromatin transition between pachynema and diplonema during meiotic prophase.
T5188	9351-9356	VBN	denotes	Based
T5189	9383-9390	VBP	denotes	suggest
T5190	9357-9359	IN	denotes	on
T5191	9360-9365	DT	denotes	these
T5192	9366-9378	NNS	denotes	observations
T5193	9378-9380	,	denotes	,
T5194	9380-9382	PRP	denotes	we
T5195	9391-9395	IN	denotes	that
T5196	9402-9407	VBZ	denotes	plays
T5197	9396-9401	NN	denotes	Dmrt7
T5198	9408-9409	DT	denotes	a
T5199	9419-9423	NN	denotes	role
T5200	9410-9418	JJ	denotes	critical
T5201	9424-9426	IN	denotes	in
T5202	9427-9428	DT	denotes	a
T5203	9453-9463	NN	denotes	transition
T5204	9429-9433	JJ	denotes	male
T5205	9434-9442	JJ	denotes	specific
T5206	9433-9434	HYPH	denotes	-
T5207	9443-9452	NN	denotes	chromatin
T5208	9464-9471	IN	denotes	between
T5209	9472-9481	NN	denotes	pachynema
T5210	9482-9485	CC	denotes	and
T5211	9486-9495	NN	denotes	diplonema
T5212	9496-9502	IN	denotes	during
T5213	9503-9510	JJ	denotes	meiotic
T5214	9511-9519	NN	denotes	prophase
T5215	9519-9520	.	denotes	.
T6759	9531-9541	NN	denotes	Expression
T6760	9542-9544	IN	denotes	of
T6761	9545-9550	NN	denotes	DMRT7
T6762	9551-9559	NNS	denotes	Proteins
T6763	9560-9562	IN	denotes	in
T6764	9563-9569	NN	denotes	Testis
T6765	9569-9737	sentence	denotes	Our previous mRNA expression analysis suggested a possible meiotic function for Dmrt7, based on the expression of Dmrt7 mRNA in the fetal gonads of the two sexes [23].
T6766	9570-9573	PRP$	denotes	Our
T6767	9599-9607	NN	denotes	analysis
T6768	9574-9582	JJ	denotes	previous
T6769	9583-9587	NN	denotes	mRNA
T6770	9588-9598	NN	denotes	expression
T6771	9608-9617	VBD	denotes	suggested
T6772	9618-9619	DT	denotes	a
T6773	9637-9645	NN	denotes	function
T6774	9620-9628	JJ	denotes	possible
T6775	9629-9636	JJ	denotes	meiotic
T6776	9646-9649	IN	denotes	for
T6777	9650-9655	NN	denotes	Dmrt7
T6778	9655-9657	,	denotes	,
T6779	9657-9662	VBN	denotes	based
T6780	9663-9665	IN	denotes	on
T6781	9666-9669	DT	denotes	the
T6782	9670-9680	NN	denotes	expression
T6783	9681-9683	IN	denotes	of
T6784	9684-9689	NN	denotes	Dmrt7
T6785	9690-9694	NN	denotes	mRNA
T6786	9695-9697	IN	denotes	in
T6787	9698-9701	DT	denotes	the
T6788	9708-9714	NNS	denotes	gonads
T6789	9702-9707	JJ	denotes	fetal
T6790	9715-9717	IN	denotes	of
T6791	9718-9721	DT	denotes	the
T6792	9726-9731	NNS	denotes	sexes
T6793	9722-9725	CD	denotes	two
T6794	9732-9733	-LRB-	denotes	[
T6795	9733-9735	CD	denotes	23
T6796	9735-9736	-RRB-	denotes	]
T6797	9736-9737	.	denotes	.
T6798	9737-9981	sentence	denotes	In the fetal ovary, Dmrt7 mRNA was detected primarily from E13.5 to E15.5, the time during which meiosis progresses from pre-meiotic replication to the pachytene stage [4], whereas Dmrt7 expression in the non-meiotic fetal testis was very low.
T6799	9738-9740	IN	denotes	In
T6800	9773-9781	VBN	denotes	detected
T6801	9741-9744	DT	denotes	the
T6802	9751-9756	NN	denotes	ovary
T6803	9745-9750	JJ	denotes	fetal
T6804	9756-9758	,	denotes	,
T6805	9758-9763	NN	denotes	Dmrt7
T6806	9764-9768	NN	denotes	mRNA
T6807	9769-9772	VBD	denotes	was
T6808	9782-9791	RB	denotes	primarily
T6809	9792-9796	IN	denotes	from
T6810	9797-9802	NN	denotes	E13.5
T6811	9803-9805	IN	denotes	to
T6812	9806-9811	NN	denotes	E15.5
T6813	9811-9813	,	denotes	,
T6814	9813-9816	DT	denotes	the
T6815	9817-9821	NN	denotes	time
T6816	9822-9828	IN	denotes	during
T6817	9843-9853	VBZ	denotes	progresses
T6818	9829-9834	WDT	denotes	which
T6819	9835-9842	NN	denotes	meiosis
T6820	9854-9858	IN	denotes	from
T6821	9859-9870	JJ	denotes	pre-meiotic
T6822	9871-9882	NN	denotes	replication
T6823	9883-9885	IN	denotes	to
T6824	9886-9889	DT	denotes	the
T6825	9900-9905	NN	denotes	stage
T6826	9890-9899	NN	denotes	pachytene
T6827	9906-9907	-LRB-	denotes	[
T6828	9907-9908	CD	denotes	4
T6829	9908-9909	-RRB-	denotes	]
T6830	9909-9911	,	denotes	,
T6831	9911-9918	IN	denotes	whereas
T6832	9968-9971	VBD	denotes	was
T6833	9919-9924	NN	denotes	Dmrt7
T6834	9925-9935	NN	denotes	expression
T6835	9936-9938	IN	denotes	in
T6836	9939-9942	DT	denotes	the
T6837	9961-9967	NN	denotes	testis
T6838	9943-9954	JJ	denotes	non-meiotic
T6839	9955-9960	JJ	denotes	fetal
T6840	9972-9976	RB	denotes	very
T6841	9977-9980	JJ	denotes	low
T6842	9980-9981	.	denotes	.
T6843	9981-10267	sentence	denotes	Because this earlier work did not examine adult Dmrt7 expression, we first performed reverse transcriptase (RT)-PCR on mRNA from ten adult organs and detected strong Dmrt7 mRNA expression in the testis and a trace of expression in heart, but not in any other tissue tested (Figure 1A).
T6844	9982-9989	IN	denotes	Because
T6845	10016-10023	VB	denotes	examine
T6846	9990-9994	DT	denotes	this
T6847	10003-10007	NN	denotes	work
T6848	9995-10002	JJR	denotes	earlier
T6849	10008-10011	VBD	denotes	did
T6850	10012-10015	RB	denotes	not
T6851	10057-10066	VBD	denotes	performed
T6852	10024-10029	JJ	denotes	adult
T6853	10036-10046	NN	denotes	expression
T6856	10048-10050	PRP	denotes	we
T6857	10051-10056	RB	denotes	first
T6858	10067-10074	JJ	denotes	reverse
T6859	10075-10088	NN	denotes	transcriptase
T6860	10094-10097	NN	denotes	PCR
T6861	10089-10090	-LRB-	denotes	(
T6862	10090-10092	NN	denotes	RT
T6863	10092-10093	-RRB-	denotes	)
T6864	10093-10094	HYPH	denotes	-
T6865	10098-10100	IN	denotes	on
T6866	10101-10105	NN	denotes	mRNA
T6867	10106-10110	IN	denotes	from
T6868	10111-10114	CD	denotes	ten
T6869	10121-10127	NNS	denotes	organs
T6870	10115-10120	JJ	denotes	adult
T6871	10128-10131	CC	denotes	and
T6872	10132-10140	VBN	denotes	detected
T6873	10141-10147	JJ	denotes	strong
T6874	10159-10169	NN	denotes	expression
T6875	10148-10153	NN	denotes	Dmrt7
T6876	10154-10158	NN	denotes	mRNA
T6877	10170-10172	IN	denotes	in
T6878	10173-10176	DT	denotes	the
T6879	10177-10183	NN	denotes	testis
T6880	10184-10187	CC	denotes	and
T6881	10188-10189	DT	denotes	a
T6882	10190-10195	NN	denotes	trace
T6883	10196-10198	IN	denotes	of
T6884	10199-10209	NN	denotes	expression
T6885	10210-10212	IN	denotes	in
T6886	10213-10218	NN	denotes	heart
T6887	10218-10220	,	denotes	,
T6888	10220-10223	CC	denotes	but
T6889	10224-10227	RB	denotes	not
T6890	10228-10230	IN	denotes	in
T6891	10231-10234	DT	denotes	any
T6892	10241-10247	NN	denotes	tissue
T6893	10235-10240	JJ	denotes	other
T6894	10248-10254	VBN	denotes	tested
T6895	10255-10256	-LRB-	denotes	(
T6896	10263-10265	NN	denotes	1A
T6897	10256-10262	NN	denotes	Figure
T6898	10265-10266	-RRB-	denotes	)
T6899	10266-10267	.	denotes	.
T6900	10267-10534	sentence	denotes	We examined the timing of Dmrt7 mRNA expression during postnatal testis development and detected strong expression beginning at 2 wk, which roughly coincides with the onset of the pachytene stage during the first synchronous wave of spermatogenesis (Figure 1B) [37].
T6901	10268-10270	PRP	denotes	We
T6902	10271-10279	VBD	denotes	examined
T6903	10280-10283	DT	denotes	the
T6904	10284-10290	NN	denotes	timing
T6905	10291-10293	IN	denotes	of
T6906	10294-10299	NN	denotes	Dmrt7
T6907	10305-10315	NN	denotes	expression
T6908	10300-10304	NN	denotes	mRNA
T6909	10316-10322	IN	denotes	during
T6910	10323-10332	JJ	denotes	postnatal
T6911	10340-10351	NN	denotes	development
T6912	10333-10339	NN	denotes	testis
T6913	10352-10355	CC	denotes	and
T6914	10356-10364	VBD	denotes	detected
T6915	10365-10371	JJ	denotes	strong
T6916	10372-10382	NN	denotes	expression
T6917	10383-10392	VBG	denotes	beginning
T6918	10393-10395	IN	denotes	at
T6919	10396-10397	CD	denotes	2
T6920	10398-10400	NNS	denotes	wk
T6921	10400-10402	,	denotes	,
T6922	10402-10407	WDT	denotes	which
T6923	10416-10425	VBZ	denotes	coincides
T6924	10408-10415	RB	denotes	roughly
T6925	10426-10430	IN	denotes	with
T6926	10431-10434	DT	denotes	the
T6927	10435-10440	NN	denotes	onset
T6928	10441-10443	IN	denotes	of
T6929	10444-10447	DT	denotes	the
T6930	10458-10463	NN	denotes	stage
T6931	10448-10457	NN	denotes	pachytene
T6932	10464-10470	IN	denotes	during
T6933	10471-10474	DT	denotes	the
T6934	10493-10497	NN	denotes	wave
T6935	10475-10480	JJ	denotes	first
T6936	10481-10492	JJ	denotes	synchronous
T6937	10498-10500	IN	denotes	of
T6938	10501-10516	NN	denotes	spermatogenesis
T6939	10517-10518	-LRB-	denotes	(
T6940	10525-10527	NN	denotes	1B
T6941	10518-10524	NN	denotes	Figure
T6942	10527-10528	-RRB-	denotes	)
T6943	10529-10530	-LRB-	denotes	[
T6944	10530-10532	CD	denotes	37
T6945	10532-10533	-RRB-	denotes	]
T6946	10533-10534	.	denotes	.
T6947	10534-10535	sentence	denotes
T6948	11354-11466	sentence	denotes	To investigate DMRT7 protein expression, we generated an antibody against the C-terminal portion of the protein.
T6949	11354-11356	TO	denotes	To
T6950	11357-11368	VB	denotes	investigate
T6951	11398-11407	VBD	denotes	generated
T6952	11369-11374	NN	denotes	DMRT7
T6953	11383-11393	NN	denotes	expression
T6954	11375-11382	NN	denotes	protein
T6955	11393-11395	,	denotes	,
T6956	11395-11397	PRP	denotes	we
T6957	11408-11410	DT	denotes	an
T6958	11411-11419	NN	denotes	antibody
T6959	11420-11427	IN	denotes	against
T6960	11428-11431	DT	denotes	the
T6961	11443-11450	NN	denotes	portion
T6962	11432-11433	NN	denotes	C
T6963	11434-11442	JJ	denotes	terminal
T6964	11433-11434	HYPH	denotes	-
T6965	11451-11453	IN	denotes	of
T6966	11454-11457	DT	denotes	the
T6967	11458-11465	NN	denotes	protein
T6968	11465-11466	.	denotes	.
T6969	11466-11600	sentence	denotes	The antibody was raised against a unique region lacking the DM domain in order to avoid cross-reaction with other DM domain proteins.
T6970	11467-11470	DT	denotes	The
T6971	11471-11479	NN	denotes	antibody
T6972	11484-11490	VBN	denotes	raised
T6973	11480-11483	VBD	denotes	was
T6974	11491-11498	IN	denotes	against
T6975	11499-11500	DT	denotes	a
T6976	11508-11514	NN	denotes	region
T6977	11501-11507	JJ	denotes	unique
T6978	11515-11522	VBG	denotes	lacking
T6979	11523-11526	DT	denotes	the
T6980	11530-11536	NN	denotes	domain
T6981	11527-11529	NN	denotes	DM
T6982	11537-11539	IN	denotes	in
T6983	11540-11545	NN	denotes	order
T6984	11546-11548	TO	denotes	to
T6985	11549-11554	VB	denotes	avoid
T6986	11555-11569	NN	denotes	cross-reaction
T6987	11570-11574	IN	denotes	with
T6988	11575-11580	JJ	denotes	other
T6989	11591-11599	NN	denotes	proteins
T6990	11581-11583	NN	denotes	DM
T6991	11584-11590	NN	denotes	domain
T6992	11599-11600	.	denotes	.
T6993	11600-11876	sentence	denotes	Immunofluorescent staining with purified DMRT7 antisera showed that DMRT7 protein is expressed predominantly in mid- to late-pachytene spermatocytes (Figure 1C), as well as in sperm, and is not detectable in other germ cell types including spermatogonia and round spermatids.
T6994	11601-11618	JJ	denotes	Immunofluorescent
T6995	11619-11627	NN	denotes	staining
T6996	11657-11663	VBD	denotes	showed
T6997	11628-11632	IN	denotes	with
T6998	11633-11641	VBN	denotes	purified
T6999	11648-11656	NNS	denotes	antisera
T7000	11642-11647	NN	denotes	DMRT7
T7001	11664-11668	IN	denotes	that
T7002	11686-11695	VBN	denotes	expressed
T7003	11669-11674	NN	denotes	DMRT7
T7004	11675-11682	NN	denotes	protein
T7005	11683-11685	VBZ	denotes	is
T7006	11696-11709	RB	denotes	predominantly
T7007	11710-11712	IN	denotes	in
T7008	11713-11716	JJ	denotes	mid
T7009	11726-11735	NN	denotes	pachytene
T7010	11716-11717	HYPH	denotes	-
T7011	11718-11720	IN	denotes	to
T7012	11721-11725	JJ	denotes	late
T7013	11725-11726	HYPH	denotes	-
T7014	11736-11749	NNS	denotes	spermatocytes
T7015	11750-11751	-LRB-	denotes	(
T7016	11758-11760	NN	denotes	1C
T7017	11751-11757	NN	denotes	Figure
T7018	11760-11761	-RRB-	denotes	)
T7019	11761-11763	,	denotes	,
T7020	11763-11765	RB	denotes	as
T7021	11771-11773	IN	denotes	as
T7022	11766-11770	RB	denotes	well
T7023	11774-11776	IN	denotes	in
T7024	11777-11782	NN	denotes	sperm
T7025	11782-11784	,	denotes	,
T7026	11784-11787	CC	denotes	and
T7027	11788-11790	VBZ	denotes	is
T7028	11791-11794	RB	denotes	not
T7029	11795-11805	JJ	denotes	detectable
T7030	11806-11808	IN	denotes	in
T7031	11809-11814	JJ	denotes	other
T7032	11825-11830	NNS	denotes	types
T7033	11815-11819	NN	denotes	germ
T7034	11820-11824	NN	denotes	cell
T7035	11831-11840	VBG	denotes	including
T7036	11841-11854	NNS	denotes	spermatogonia
T7037	11855-11858	CC	denotes	and
T7038	11859-11864	JJ	denotes	round
T7039	11865-11875	NNS	denotes	spermatids
T7040	11875-11876	.	denotes	.
T7041	11876-11990	sentence	denotes	We did not detect DMRT7 protein in somatic cells such as Sertoli cells, peritubular myoid cells, or Leydig cells.
T7042	11877-11879	PRP	denotes	We
T7043	11888-11894	VB	denotes	detect
T7044	11880-11883	VBD	denotes	did
T7045	11884-11887	RB	denotes	not
T7046	11895-11900	NN	denotes	DMRT7
T7047	11901-11908	NN	denotes	protein
T7048	11909-11911	IN	denotes	in
T7049	11912-11919	JJ	denotes	somatic
T7050	11920-11925	NNS	denotes	cells
T7051	11926-11930	JJ	denotes	such
T7052	11931-11933	IN	denotes	as
T7053	11934-11941	NNP	denotes	Sertoli
T7054	11942-11947	NNS	denotes	cells
T7055	11947-11949	,	denotes	,
T7056	11949-11960	JJ	denotes	peritubular
T7057	11967-11972	NNS	denotes	cells
T7058	11961-11966	JJ	denotes	myoid
T7059	11972-11974	,	denotes	,
T7060	11974-11976	CC	denotes	or
T7061	11977-11983	NNP	denotes	Leydig
T7062	11984-11989	NNS	denotes	cells
T7063	11989-11990	.	denotes	.
T7064	11990-12169	sentence	denotes	To more precisely determine the pachytene stages of DMRT7 expression, we double-stained with an antibody to GATA1, which is expressed in Sertoli cells from stages VII to IX [38].
T7065	11991-11993	TO	denotes	To
T7066	12009-12018	VB	denotes	determine
T7067	11994-11998	RBR	denotes	more
T7068	11999-12008	RB	denotes	precisely
T7069	12071-12078	VBN	denotes	stained
T7070	12019-12022	DT	denotes	the
T7071	12033-12039	NNS	denotes	stages
T7072	12023-12032	NN	denotes	pachytene
T7073	12040-12042	IN	denotes	of
T7074	12043-12048	NN	denotes	DMRT7
T7075	12049-12059	NN	denotes	expression
T7076	12059-12061	,	denotes	,
T7077	12061-12063	PRP	denotes	we
T7078	12064-12070	RB	denotes	double
T7079	12070-12071	HYPH	denotes	-
T7080	12079-12083	IN	denotes	with
T7081	12084-12086	DT	denotes	an
T7082	12087-12095	NN	denotes	antibody
T7083	12096-12098	IN	denotes	to
T7084	12099-12104	NN	denotes	GATA1
T7085	12104-12106	,	denotes	,
T7086	12106-12111	WDT	denotes	which
T7087	12115-12124	VBN	denotes	expressed
T7088	12112-12114	VBZ	denotes	is
T7089	12125-12127	IN	denotes	in
T7090	12128-12135	NNP	denotes	Sertoli
T7091	12136-12141	NNS	denotes	cells
T7092	12142-12146	IN	denotes	from
T7093	12147-12153	NNS	denotes	stages
T7094	12154-12157	CD	denotes	VII
T7095	12158-12160	IN	denotes	to
T7096	12161-12163	CD	denotes	IX
T7097	12164-12165	-LRB-	denotes	[
T7098	12165-12167	CD	denotes	38
T7099	12167-12168	-RRB-	denotes	]
T7100	12168-12169	.	denotes	.
T7101	12169-12341	sentence	denotes	This confirmed that DMRT7 is expressed in mid- to late-pachytene spermatocytes, starting slightly earlier than stage VII and extending through stage IX (unpublished data).
T7102	12170-12174	DT	denotes	This
T7103	12175-12184	VBD	denotes	confirmed
T7104	12185-12189	IN	denotes	that
T7105	12199-12208	VBN	denotes	expressed
T7106	12190-12195	NN	denotes	DMRT7
T7107	12196-12198	VBZ	denotes	is
T7108	12209-12211	IN	denotes	in
T7109	12212-12215	JJ	denotes	mid
T7110	12225-12234	NN	denotes	pachytene
T7111	12215-12216	HYPH	denotes	-
T7112	12217-12219	IN	denotes	to
T7113	12220-12224	JJ	denotes	late
T7114	12224-12225	HYPH	denotes	-
T7115	12235-12248	NNS	denotes	spermatocytes
T7116	12248-12250	,	denotes	,
T7117	12250-12258	VBG	denotes	starting
T7118	12259-12267	RB	denotes	slightly
T7119	12268-12275	RBR	denotes	earlier
T7120	12276-12280	IN	denotes	than
T7121	12281-12286	NN	denotes	stage
T7122	12287-12290	CD	denotes	VII
T7123	12291-12294	CC	denotes	and
T7124	12295-12304	VBG	denotes	extending
T7125	12305-12312	IN	denotes	through
T7126	12313-12318	NN	denotes	stage
T7127	12319-12321	CD	denotes	IX
T7128	12322-12323	-LRB-	denotes	(
T7129	12335-12339	NNS	denotes	data
T7130	12323-12334	JJ	denotes	unpublished
T7131	12339-12340	-RRB-	denotes	)
T7132	12340-12341	.	denotes	.
T7133	12341-12494	sentence	denotes	Within pachytene spermatocytes, DMRT7 is concentrated in the XY body, or sex body, a densely staining chromatin domain that harbors the sex chromosomes.
T7134	12342-12348	IN	denotes	Within
T7135	12383-12395	VBN	denotes	concentrated
T7136	12349-12358	NN	denotes	pachytene
T7137	12359-12372	NNS	denotes	spermatocytes
T7138	12372-12374	,	denotes	,
T7139	12374-12379	NN	denotes	DMRT7
T7140	12380-12382	VBZ	denotes	is
T7141	12396-12398	IN	denotes	in
T7142	12399-12402	DT	denotes	the
T7143	12406-12410	NN	denotes	body
T7144	12403-12405	NN	denotes	XY
T7145	12410-12412	,	denotes	,
T7146	12412-12414	CC	denotes	or
T7147	12415-12418	NN	denotes	sex
T7148	12419-12423	NN	denotes	body
T7149	12423-12425	,	denotes	,
T7150	12425-12426	DT	denotes	a
T7151	12454-12460	NN	denotes	domain
T7152	12427-12434	RB	denotes	densely
T7153	12435-12443	VBG	denotes	staining
T7154	12444-12453	NN	denotes	chromatin
T7155	12461-12465	WDT	denotes	that
T7156	12466-12473	VBZ	denotes	harbors
T7157	12474-12477	DT	denotes	the
T7158	12482-12493	NNS	denotes	chromosomes
T7159	12478-12481	NN	denotes	sex
T7160	12493-12494	.	denotes	.
T7161	12494-12652	sentence	denotes	These undergo transcriptional inactivation and heterochromatinization as a result of their incomplete pairing during prophase of mammalian male meiosis [17].
T7162	12495-12500	DT	denotes	These
T7163	12501-12508	VBP	denotes	undergo
T7164	12509-12524	JJ	denotes	transcriptional
T7165	12525-12537	NN	denotes	inactivation
T7166	12538-12541	CC	denotes	and
T7167	12542-12564	NN	denotes	heterochromatinization
T7168	12565-12567	IN	denotes	as
T7169	12568-12569	DT	denotes	a
T7170	12570-12576	NN	denotes	result
T7171	12577-12579	IN	denotes	of
T7172	12580-12585	PRP$	denotes	their
T7173	12597-12604	NN	denotes	pairing
T7174	12586-12596	JJ	denotes	incomplete
T7175	12605-12611	IN	denotes	during
T7176	12612-12620	NN	denotes	prophase
T7177	12621-12623	IN	denotes	of
T7178	12624-12633	JJ	denotes	mammalian
T7179	12639-12646	NN	denotes	meiosis
T7180	12634-12638	JJ	denotes	male
T7181	12647-12648	-LRB-	denotes	[
T7182	12648-12650	CD	denotes	17
T7183	12650-12651	-RRB-	denotes	]
T7184	12651-12652	.	denotes	.
T7185	12652-12865	sentence	denotes	To verify DMRT7 protein expression in the XY body, we double-stained mouse testis sections for DMRT7 and small ubiquitin-related modifier 1 (SUMO-1), which is concentrated in the XY body during pachynema [39,40].
T7186	12653-12655	TO	denotes	To
T7187	12656-12662	VB	denotes	verify
T7188	12714-12721	VBD	denotes	stained
T7189	12663-12668	NN	denotes	DMRT7
T7190	12677-12687	NN	denotes	expression
T7191	12669-12676	NN	denotes	protein
T7192	12688-12690	IN	denotes	in
T7193	12691-12694	DT	denotes	the
T7194	12698-12702	NN	denotes	body
T7195	12695-12697	NN	denotes	XY
T7196	12702-12704	,	denotes	,
T7197	12704-12706	PRP	denotes	we
T7198	12707-12713	RB	denotes	double
T7199	12713-12714	HYPH	denotes	-
T7200	12722-12727	NN	denotes	mouse
T7201	12728-12734	NN	denotes	testis
T7202	12735-12743	NNS	denotes	sections
T7203	12744-12747	IN	denotes	for
T7204	12748-12753	NN	denotes	DMRT7
T7205	12754-12757	CC	denotes	and
T7206	12758-12763	JJ	denotes	small
T7207	12782-12790	NN	denotes	modifier
T7208	12764-12773	NN	denotes	ubiquitin
T7209	12774-12781	VBN	denotes	related
T7210	12773-12774	HYPH	denotes	-
T7211	12791-12792	CD	denotes	1
T7212	12793-12794	-LRB-	denotes	(
T7213	12794-12798	NN	denotes	SUMO
T7214	12798-12799	HYPH	denotes	-
T7215	12799-12800	CD	denotes	1
T7216	12800-12801	-RRB-	denotes	)
T7217	12801-12803	,	denotes	,
T7218	12803-12808	WDT	denotes	which
T7219	12812-12824	VBN	denotes	concentrated
T7220	12809-12811	VBZ	denotes	is
T7221	12825-12827	IN	denotes	in
T7222	12828-12831	DT	denotes	the
T7223	12835-12839	NN	denotes	body
T7224	12832-12834	NN	denotes	XY
T7225	12840-12846	IN	denotes	during
T7226	12847-12856	NN	denotes	pachynema
T7227	12857-12858	-LRB-	denotes	[
T7228	12861-12863	CD	denotes	40
T7229	12858-12860	CD	denotes	39
T7230	12860-12861	,	denotes	,
T7231	12863-12864	-RRB-	denotes	]
T7232	12864-12865	.	denotes	.
T7233	12865-12986	sentence	denotes	DMRT7 and SUMO-1 were colocalized, confirming that DMRT7 protein is preferentially localized to the XY body (Figure 1D).
T7234	12866-12871	NN	denotes	DMRT7
T7235	12888-12899	VBN	denotes	colocalized
T7236	12872-12875	CC	denotes	and
T7237	12876-12880	NN	denotes	SUMO
T7238	12880-12881	HYPH	denotes	-
T7239	12881-12882	CD	denotes	1
T7240	12883-12887	VBD	denotes	were
T7241	12899-12901	,	denotes	,
T7242	12901-12911	VBG	denotes	confirming
T7243	12912-12916	IN	denotes	that
T7244	12949-12958	VBN	denotes	localized
T7245	12917-12922	NN	denotes	DMRT7
T7246	12923-12930	NN	denotes	protein
T7247	12931-12933	VBZ	denotes	is
T7248	12934-12948	RB	denotes	preferentially
T7249	12959-12961	IN	denotes	to
T7250	12962-12965	DT	denotes	the
T7251	12969-12973	NN	denotes	body
T7252	12966-12968	NN	denotes	XY
T7253	12974-12975	-LRB-	denotes	(
T7254	12982-12984	NN	denotes	1D
T7255	12975-12981	NN	denotes	Figure
T7256	12984-12985	-RRB-	denotes	)
T7257	12985-12986	.	denotes	.
T7258	12986-13118	sentence	denotes	We also confirmed XY body localization of DMRT7 by double staining for other markers including Ub-H2A and γH2AX (unpublished data).
T7259	12987-12989	PRP	denotes	We
T7260	12995-13004	VBD	denotes	confirmed
T7261	12990-12994	RB	denotes	also
T7262	13005-13007	NN	denotes	XY
T7263	13013-13025	NN	denotes	localization
T7264	13008-13012	NN	denotes	body
T7265	13026-13028	IN	denotes	of
T7266	13029-13034	NN	denotes	DMRT7
T7267	13035-13037	IN	denotes	by
T7268	13038-13044	JJ	denotes	double
T7269	13045-13053	NN	denotes	staining
T7270	13054-13057	IN	denotes	for
T7271	13058-13063	JJ	denotes	other
T7272	13064-13071	NNS	denotes	markers
T7273	13072-13081	VBG	denotes	including
T7274	13082-13084	NN	denotes	Ub
T7275	13085-13088	NN	denotes	H2A
T7276	13084-13085	HYPH	denotes	-
T7277	13089-13092	CC	denotes	and
T7278	13093-13098	NN	denotes	γH2AX
T7279	13099-13100	-LRB-	denotes	(
T7280	13112-13116	NNS	denotes	data
T7281	13100-13111	JJ	denotes	unpublished
T7282	13116-13117	-RRB-	denotes	)
T7283	13117-13118	.	denotes	.
T7284	13118-13209	sentence	denotes	DMRT7 is not preferentially localized to the XY body at all stages but instead is dynamic.
T7285	13119-13124	NN	denotes	DMRT7
T7286	13147-13156	VBN	denotes	localized
T7287	13125-13127	VBZ	denotes	is
T7288	13128-13131	RB	denotes	not
T7289	13132-13146	RB	denotes	preferentially
T7290	13157-13159	IN	denotes	to
T7291	13160-13163	DT	denotes	the
T7292	13167-13171	NN	denotes	body
T7293	13164-13166	NN	denotes	XY
T7294	13172-13174	IN	denotes	at
T7295	13175-13178	DT	denotes	all
T7296	13179-13185	NNS	denotes	stages
T7297	13186-13189	CC	denotes	but
T7298	13190-13197	RB	denotes	instead
T7299	13198-13200	VBZ	denotes	is
T7300	13201-13208	JJ	denotes	dynamic
T7301	13208-13209	.	denotes	.
T7302	13209-13411	sentence	denotes	Based on epithelial staging, it appears that DMRT7 localizes to the XY body from mid- to late-pachynema, becomes diffusely distributed in late-pachynema, and disappears in diplonema (unpublished data).
T7303	13210-13215	VBN	denotes	Based
T7304	13242-13249	VBZ	denotes	appears
T7305	13216-13218	IN	denotes	on
T7306	13219-13229	JJ	denotes	epithelial
T7307	13230-13237	NN	denotes	staging
T7308	13237-13239	,	denotes	,
T7309	13239-13241	PRP	denotes	it
T7310	13250-13254	IN	denotes	that
T7311	13261-13270	VBZ	denotes	localizes
T7312	13255-13260	NN	denotes	DMRT7
T7313	13271-13273	IN	denotes	to
T7314	13274-13277	DT	denotes	the
T7315	13281-13285	NN	denotes	body
T7316	13278-13280	NN	denotes	XY
T7317	13286-13290	IN	denotes	from
T7318	13291-13294	JJ	denotes	mid
T7319	13304-13313	NN	denotes	pachynema
T7320	13294-13295	HYPH	denotes	-
T7321	13296-13298	IN	denotes	to
T7322	13299-13303	JJ	denotes	late
T7323	13303-13304	HYPH	denotes	-
T7324	13313-13315	,	denotes	,
T7325	13315-13322	VBZ	denotes	becomes
T7326	13323-13332	RB	denotes	diffusely
T7327	13333-13344	JJ	denotes	distributed
T7328	13345-13347	IN	denotes	in
T7329	13348-13352	JJ	denotes	late
T7330	13353-13362	NN	denotes	pachynema
T7331	13352-13353	HYPH	denotes	-
T7332	13362-13364	,	denotes	,
T7333	13364-13367	CC	denotes	and
T7334	13368-13378	VBZ	denotes	disappears
T7335	13379-13381	IN	denotes	in
T7336	13382-13391	NN	denotes	diplonema
T7337	13392-13393	-LRB-	denotes	(
T7338	13405-13409	NNS	denotes	data
T7339	13393-13404	JJ	denotes	unpublished
T7340	13409-13410	-RRB-	denotes	)
T7341	13410-13411	.	denotes	.
T7342	13411-13487	sentence	denotes	This localization was confirmed by staining of meiotic spreads (Figure S1).
T7343	13412-13416	DT	denotes	This
T7344	13417-13429	NN	denotes	localization
T7345	13434-13443	VBN	denotes	confirmed
T7346	13430-13433	VBD	denotes	was
T7347	13444-13446	IN	denotes	by
T7348	13447-13455	NN	denotes	staining
T7349	13456-13458	IN	denotes	of
T7350	13459-13466	JJ	denotes	meiotic
T7351	13467-13474	NNS	denotes	spreads
T7352	13475-13476	-LRB-	denotes	(
T7353	13483-13485	NN	denotes	S1
T7354	13476-13482	NN	denotes	Figure
T7355	13485-13486	-RRB-	denotes	)
T7356	13486-13487	.	denotes	.
T7357	13487-13617	sentence	denotes	DMRT7 also is specifically localized in sperm, with antibody staining mainly in the perinuclear ring of the sperm head manchette.
T7358	13488-13493	NN	denotes	DMRT7
T7359	13515-13524	VBN	denotes	localized
T7360	13494-13498	RB	denotes	also
T7361	13499-13501	VBZ	denotes	is
T7362	13502-13514	RB	denotes	specifically
T7363	13525-13527	IN	denotes	in
T7364	13528-13533	NN	denotes	sperm
T7365	13533-13535	,	denotes	,
T7366	13535-13539	IN	denotes	with
T7367	13540-13548	NN	denotes	antibody
T7368	13549-13557	NN	denotes	staining
T7369	13558-13564	RB	denotes	mainly
T7370	13565-13567	IN	denotes	in
T7371	13568-13571	DT	denotes	the
T7372	13584-13588	NN	denotes	ring
T7373	13572-13583	JJ	denotes	perinuclear
T7374	13589-13591	IN	denotes	of
T7375	13592-13595	DT	denotes	the
T7376	13607-13616	NN	denotes	manchette
T7377	13596-13601	NN	denotes	sperm
T7378	13602-13606	NN	denotes	head
T7379	13616-13617	.	denotes	.
T7380	13617-13745	sentence	denotes	This staining coincided with the epithelial stages in which DMRT7 localizes to the XY body in spermatocytes (Figure 1C and 1D).
T7381	13618-13622	DT	denotes	This
T7382	13623-13631	NN	denotes	staining
T7383	13632-13641	VBD	denotes	coincided
T7384	13642-13646	IN	denotes	with
T7385	13647-13650	DT	denotes	the
T7386	13662-13668	NNS	denotes	stages
T7387	13651-13661	JJ	denotes	epithelial
T7388	13669-13671	IN	denotes	in
T7389	13684-13693	VBZ	denotes	localizes
T7390	13672-13677	WDT	denotes	which
T7391	13678-13683	NN	denotes	DMRT7
T7392	13694-13696	IN	denotes	to
T7393	13697-13700	DT	denotes	the
T7394	13704-13708	NN	denotes	body
T7395	13701-13703	NN	denotes	XY
T7396	13709-13711	IN	denotes	in
T7397	13712-13725	NNS	denotes	spermatocytes
T7398	13726-13727	-LRB-	denotes	(
T7399	13734-13736	NN	denotes	1C
T7400	13727-13733	NN	denotes	Figure
T7401	13737-13740	CC	denotes	and
T7402	13741-13743	NN	denotes	1D
T7403	13743-13744	-RRB-	denotes	)
T7404	13744-13745	.	denotes	.
T8160	13747-13755	VBN	denotes	Targeted
T8161	13756-13764	NN	denotes	Deletion
T8162	13765-13767	IN	denotes	of
T8163	13768-13773	NN	denotes	Dmrt7
T8164	13773-13947	sentence	denotes	To establish the functional requirement for Dmrt7, we generated Dmrt7 −/− mice by targeted disruption in embryonic stem (ES) cells using a strategy diagrammed in Figure S2A.
T8165	13774-13776	TO	denotes	To
T8166	13777-13786	VB	denotes	establish
T8167	13828-13837	VBD	denotes	generated
T8168	13787-13790	DT	denotes	the
T8169	13802-13813	NN	denotes	requirement
T8170	13791-13801	JJ	denotes	functional
T8171	13814-13817	IN	denotes	for
T8172	13818-13823	NN	denotes	Dmrt7
T8173	13823-13825	,	denotes	,
T8174	13825-13827	PRP	denotes	we
T8175	13838-13843	NN	denotes	Dmrt7
T8176	13848-13852	NNS	denotes	mice
T8177	13844-13845	SYM	denotes	−
T8178	13845-13846	HYPH	denotes	/
T8179	13846-13847	SYM	denotes	−
T8180	13853-13855	IN	denotes	by
T8181	13856-13864	VBN	denotes	targeted
T8182	13865-13875	NN	denotes	disruption
T8183	13876-13878	IN	denotes	in
T8184	13879-13888	JJ	denotes	embryonic
T8185	13889-13893	NN	denotes	stem
T8186	13899-13904	NNS	denotes	cells
T8187	13894-13895	-LRB-	denotes	(
T8188	13895-13897	NN	denotes	ES
T8189	13897-13898	-RRB-	denotes	)
T8190	13905-13910	VBG	denotes	using
T8191	13911-13912	DT	denotes	a
T8192	13913-13921	NN	denotes	strategy
T8193	13922-13932	VBN	denotes	diagrammed
T8194	13933-13935	IN	denotes	in
T8195	13936-13942	NN	denotes	Figure
T8196	13943-13946	NN	denotes	S2A
T8197	13946-13947	.	denotes	.
T8198	13947-14035	sentence	denotes	The Dmrt7 gene has nine exons with the DM domain encoded by the second and third exons.
T8199	13948-13951	DT	denotes	The
T8200	13958-13962	NN	denotes	gene
T8201	13952-13957	NN	denotes	Dmrt7
T8202	13963-13966	VBZ	denotes	has
T8203	13967-13971	CD	denotes	nine
T8204	13972-13977	NNS	denotes	exons
T8205	13978-13982	IN	denotes	with
T8206	13983-13986	DT	denotes	the
T8207	13990-13996	NN	denotes	domain
T8208	13987-13989	NN	denotes	DM
T8209	13997-14004	VBN	denotes	encoded
T8210	14005-14007	IN	denotes	by
T8211	14008-14011	DT	denotes	the
T8212	14029-14034	NNS	denotes	exons
T8213	14012-14018	JJ	denotes	second
T8214	14019-14022	CC	denotes	and
T8215	14023-14028	JJ	denotes	third
T8216	14034-14035	.	denotes	.
T8217	14035-14318	sentence	denotes	Because the DM domain is essential for function of other genes, including mab-3, mab-23, and dsx [18,19,41], we generated a conditionally targeted “floxed” allele in which the DM domain–containing exons of Dmrt7 are flanked by recognition sites for the Cre recombinase (loxP sites).
T8218	14036-14043	IN	denotes	Because
T8219	14058-14060	VBZ	denotes	is
T8220	14044-14047	DT	denotes	the
T8221	14051-14057	NN	denotes	domain
T8222	14048-14050	NN	denotes	DM
T8223	14148-14157	VBD	denotes	generated
T8224	14061-14070	JJ	denotes	essential
T8225	14071-14074	IN	denotes	for
T8226	14075-14083	NN	denotes	function
T8227	14084-14086	IN	denotes	of
T8228	14087-14092	JJ	denotes	other
T8229	14093-14098	NNS	denotes	genes
T8230	14098-14100	,	denotes	,
T8231	14100-14109	VBG	denotes	including
T8232	14110-14113	NN	denotes	mab
T8233	14113-14114	HYPH	denotes	-
T8234	14114-14115	CD	denotes	3
T8235	14115-14117	,	denotes	,
T8236	14117-14120	NN	denotes	mab
T8237	14120-14121	HYPH	denotes	-
T8238	14121-14123	CD	denotes	23
T8239	14123-14125	,	denotes	,
T8240	14125-14128	CC	denotes	and
T8241	14129-14132	NN	denotes	dsx
T8242	14133-14134	-LRB-	denotes	[
T8243	14140-14142	CD	denotes	41
T8244	14134-14136	CD	denotes	18
T8245	14136-14137	,	denotes	,
T8246	14137-14139	CD	denotes	19
T8247	14139-14140	,	denotes	,
T8248	14142-14143	-RRB-	denotes	]
T8249	14143-14145	,	denotes	,
T8250	14145-14147	PRP	denotes	we
T8251	14158-14159	DT	denotes	a
T8252	14192-14198	NN	denotes	allele
T8253	14160-14173	RB	denotes	conditionally
T8254	14174-14182	VBN	denotes	targeted
T8255	14183-14184	``	denotes	“
T8256	14184-14190	VBN	denotes	floxed
T8257	14190-14191	''	denotes	”
T8258	14199-14201	IN	denotes	in
T8259	14252-14259	VBN	denotes	flanked
T8260	14202-14207	WDT	denotes	which
T8261	14208-14211	DT	denotes	the
T8262	14233-14238	NNS	denotes	exons
T8263	14212-14214	NN	denotes	DM
T8264	14215-14221	NN	denotes	domain
T8265	14222-14232	VBG	denotes	containing
T8266	14221-14222	HYPH	denotes	–
T8267	14239-14241	IN	denotes	of
T8268	14242-14247	NN	denotes	Dmrt7
T8269	14248-14251	VBP	denotes	are
T8270	14260-14262	IN	denotes	by
T8271	14263-14274	NN	denotes	recognition
T8272	14275-14280	NNS	denotes	sites
T8273	14281-14284	IN	denotes	for
T8274	14285-14288	DT	denotes	the
T8275	14293-14304	NN	denotes	recombinase
T8276	14289-14292	NN	denotes	Cre
T8277	14305-14306	-LRB-	denotes	(
T8278	14311-14316	NNS	denotes	sites
T8279	14306-14310	NN	denotes	loxP
T8280	14316-14317	-RRB-	denotes	)
T8281	14317-14318	.	denotes	.
T8282	14318-14426	sentence	denotes	The targeting vector also contained a neomycin resistance cassette (neo) flanked by Flpe recognition sites.
T8283	14319-14322	DT	denotes	The
T8284	14333-14339	NN	denotes	vector
T8285	14323-14332	NN	denotes	targeting
T8286	14345-14354	VBD	denotes	contained
T8287	14340-14344	RB	denotes	also
T8288	14355-14356	DT	denotes	a
T8289	14377-14385	NN	denotes	cassette
T8290	14357-14365	NN	denotes	neomycin
T8291	14366-14376	NN	denotes	resistance
T8292	14386-14387	-LRB-	denotes	(
T8293	14387-14390	NN	denotes	neo
T8294	14390-14391	-RRB-	denotes	)
T8295	14392-14399	VBN	denotes	flanked
T8296	14400-14402	IN	denotes	by
T8297	14403-14407	NN	denotes	Flpe
T8298	14420-14425	NNS	denotes	sites
T8299	14408-14419	NN	denotes	recognition
T8300	14425-14426	.	denotes	.
T8301	14426-14586	sentence	denotes	The removal of these sequences by Cre-mediated recombination eliminates the DM domain and the translational start site, thus generating a putative null allele.
T8302	14427-14430	DT	denotes	The
T8303	14431-14438	NN	denotes	removal
T8304	14488-14498	VBZ	denotes	eliminates
T8305	14439-14441	IN	denotes	of
T8306	14442-14447	DT	denotes	these
T8307	14448-14457	NNS	denotes	sequences
T8308	14458-14460	IN	denotes	by
T8309	14461-14464	NN	denotes	Cre
T8310	14465-14473	VBN	denotes	mediated
T8311	14464-14465	HYPH	denotes	-
T8312	14474-14487	NN	denotes	recombination
T8313	14499-14502	DT	denotes	the
T8314	14506-14512	NN	denotes	domain
T8315	14503-14505	NN	denotes	DM
T8316	14513-14516	CC	denotes	and
T8317	14517-14520	DT	denotes	the
T8318	14541-14545	NN	denotes	site
T8319	14521-14534	JJ	denotes	translational
T8320	14535-14540	NN	denotes	start
T8321	14545-14547	,	denotes	,
T8322	14547-14551	RB	denotes	thus
T8323	14552-14562	VBG	denotes	generating
T8324	14563-14564	DT	denotes	a
T8325	14579-14585	NN	denotes	allele
T8326	14565-14573	JJ	denotes	putative
T8327	14574-14578	JJ	denotes	null
T8328	14585-14586	.	denotes	.
T8329	14586-14738	sentence	denotes	We identified three homologously targeted ES cell clones by Southern blotting (Figure S2B) and injected cells from two clones into C57BL/6 blastocysts.
T8330	14587-14589	PRP	denotes	We
T8331	14590-14600	VBD	denotes	identified
T8332	14601-14606	CD	denotes	three
T8333	14637-14643	NNS	denotes	clones
T8334	14607-14619	RB	denotes	homologously
T8335	14620-14628	VBN	denotes	targeted
T8336	14629-14631	NN	denotes	ES
T8337	14632-14636	NN	denotes	cell
T8338	14644-14646	IN	denotes	by
T8339	14647-14655	NNP	denotes	Southern
T8340	14656-14664	NN	denotes	blotting
T8341	14665-14666	-LRB-	denotes	(
T8342	14673-14676	NN	denotes	S2B
T8343	14666-14672	NN	denotes	Figure
T8344	14676-14677	-RRB-	denotes	)
T8345	14678-14681	CC	denotes	and
T8346	14682-14690	VBD	denotes	injected
T8347	14691-14696	NNS	denotes	cells
T8348	14697-14701	IN	denotes	from
T8349	14702-14705	CD	denotes	two
T8350	14706-14712	NNS	denotes	clones
T8351	14713-14717	IN	denotes	into
T8352	14718-14723	NN	denotes	C57BL
T8353	14726-14737	NNS	denotes	blastocysts
T8354	14723-14724	HYPH	denotes	/
T8355	14724-14725	CD	denotes	6
T8356	14737-14738	.	denotes	.
T8357	14738-14831	sentence	denotes	Chimeric animals from both cell lines transmitted the targeted allele through the germ line.
T8358	14739-14747	JJ	denotes	Chimeric
T8359	14748-14755	NNS	denotes	animals
T8360	14777-14788	VBD	denotes	transmitted
T8361	14756-14760	IN	denotes	from
T8362	14761-14765	DT	denotes	both
T8363	14771-14776	NNS	denotes	lines
T8364	14766-14770	NN	denotes	cell
T8365	14789-14792	DT	denotes	the
T8366	14802-14808	NN	denotes	allele
T8367	14793-14801	VBN	denotes	targeted
T8368	14809-14816	IN	denotes	through
T8369	14817-14820	DT	denotes	the
T8370	14826-14830	NN	denotes	line
T8371	14821-14825	NN	denotes	germ
T8372	14830-14831	.	denotes	.
T8373	14831-15036	sentence	denotes	Targeted animals were bred to β-actin Cre mice to delete the DM domain–encoding exons, generating the Dmrt7− allele, or to Flpe transgenic mice to delete the neo cassette, generating the Dmrt7flox allele.
T8374	14832-14840	VBN	denotes	Targeted
T8375	14841-14848	NNS	denotes	animals
T8376	14854-14858	VBN	denotes	bred
T8377	14849-14853	VBD	denotes	were
T8378	14859-14861	IN	denotes	to
T8379	14862-14863	NN	denotes	β
T8380	14864-14869	NN	denotes	actin
T8381	14863-14864	HYPH	denotes	-
T8382	14874-14878	NNS	denotes	mice
T8383	14870-14873	NN	denotes	Cre
T8384	14879-14881	TO	denotes	to
T8385	14882-14888	VB	denotes	delete
T8386	14889-14892	DT	denotes	the
T8387	14912-14917	NNS	denotes	exons
T8388	14893-14895	NN	denotes	DM
T8389	14896-14902	NN	denotes	domain
T8390	14903-14911	VBG	denotes	encoding
T8391	14902-14903	HYPH	denotes	–
T8392	14917-14919	,	denotes	,
T8393	14919-14929	VBG	denotes	generating
T8394	14930-14933	DT	denotes	the
T8395	14941-14947	NN	denotes	allele
T8396	14934-14939	NN	denotes	Dmrt7
T8397	14939-14940	HYPH	denotes	−
T8398	14947-14949	,	denotes	,
T8399	14949-14951	CC	denotes	or
T8400	14952-14954	IN	denotes	to
T8401	14955-14959	NN	denotes	Flpe
T8402	14971-14975	NNS	denotes	mice
T8403	14960-14970	JJ	denotes	transgenic
T8404	14976-14978	TO	denotes	to
T8405	14979-14985	VB	denotes	delete
T8406	14986-14989	DT	denotes	the
T8407	14994-15002	NN	denotes	cassette
T8408	14990-14993	NN	denotes	neo
T8409	15002-15004	,	denotes	,
T8410	15004-15014	VBG	denotes	generating
T8411	15015-15018	DT	denotes	the
T8412	15029-15035	NN	denotes	allele
T8413	15019-15028	NN	denotes	Dmrt7flox
T8414	15035-15036	.	denotes	.
T8415	15036-15092	sentence	denotes	Dmrt7+/− mice were interbred to generate Dmrt7−/− mice.
T8416	15037-15042	NN	denotes	Dmrt7
T8417	15046-15050	NNS	denotes	mice
T8418	15042-15043	SYM	denotes	+
T8419	15043-15044	HYPH	denotes	/
T8420	15044-15045	SYM	denotes	−
T8421	15056-15065	VBN	denotes	interbred
T8422	15051-15055	VBD	denotes	were
T8423	15066-15068	TO	denotes	to
T8424	15069-15077	VB	denotes	generate
T8425	15078-15083	NN	denotes	Dmrt7
T8426	15087-15091	NNS	denotes	mice
T8427	15083-15084	SYM	denotes	−
T8428	15084-15085	HYPH	denotes	/
T8429	15085-15086	SYM	denotes	−
T8430	15091-15092	.	denotes	.
T8431	15092-15320	sentence	denotes	To confirm the lack of functional DMRT7 protein in Dmrt7−/−testes, we stained meiotic spreads from Dmrt7 mutants (Figure S1) and sections from mutant testes (Figure S2C) and carried out western blot analysis (unpublished data).
T8432	15093-15095	TO	denotes	To
T8433	15096-15103	VB	denotes	confirm
T8434	15163-15170	VBD	denotes	stained
T8435	15104-15107	DT	denotes	the
T8436	15108-15112	NN	denotes	lack
T8437	15113-15115	IN	denotes	of
T8438	15116-15126	JJ	denotes	functional
T8439	15133-15140	NN	denotes	protein
T8440	15127-15132	NN	denotes	DMRT7
T8441	15141-15143	IN	denotes	in
T8442	15144-15149	NN	denotes	Dmrt7
T8443	15152-15158	NNS	denotes	testes
T8444	15149-15150	SYM	denotes	−
T8445	15150-15151	HYPH	denotes	/
T8446	15151-15152	SYM	denotes	−
T8447	15158-15160	,	denotes	,
T8448	15160-15162	PRP	denotes	we
T8449	15171-15178	JJ	denotes	meiotic
T8450	15179-15186	NNS	denotes	spreads
T8451	15187-15191	IN	denotes	from
T8452	15192-15197	NN	denotes	Dmrt7
T8453	15198-15205	NNS	denotes	mutants
T8454	15206-15207	-LRB-	denotes	(
T8455	15214-15216	NN	denotes	S1
T8456	15207-15213	NN	denotes	Figure
T8457	15216-15217	-RRB-	denotes	)
T8458	15218-15221	CC	denotes	and
T8459	15222-15230	NNS	denotes	sections
T8460	15231-15235	IN	denotes	from
T8461	15236-15242	NN	denotes	mutant
T8462	15243-15249	NNS	denotes	testes
T8463	15250-15251	-LRB-	denotes	(
T8464	15258-15261	NN	denotes	S2C
T8465	15251-15257	NN	denotes	Figure
T8466	15261-15262	-RRB-	denotes	)
T8467	15263-15266	CC	denotes	and
T8468	15267-15274	VBD	denotes	carried
T8469	15275-15278	RP	denotes	out
T8470	15279-15286	NNP	denotes	western
T8471	15287-15291	NN	denotes	blot
T8472	15292-15300	NN	denotes	analysis
T8473	15301-15302	-LRB-	denotes	(
T8474	15314-15318	NNS	denotes	data
T8475	15302-15313	JJ	denotes	unpublished
T8476	15318-15319	-RRB-	denotes	)
T8477	15319-15320	.	denotes	.
T8478	15320-15385	sentence	denotes	In each case, we detected no DMRT7 protein in the mutant testes.
T8479	15321-15323	IN	denotes	In
T8480	15338-15346	VBD	denotes	detected
T8481	15324-15328	DT	denotes	each
T8482	15329-15333	NN	denotes	case
T8483	15333-15335	,	denotes	,
T8484	15335-15337	PRP	denotes	we
T8485	15347-15349	DT	denotes	no
T8486	15356-15363	NN	denotes	protein
T8487	15350-15355	NN	denotes	DMRT7
T8488	15364-15366	IN	denotes	in
T8489	15367-15370	DT	denotes	the
T8490	15378-15384	NNS	denotes	testes
T8491	15371-15377	NN	denotes	mutant
T8492	15384-15385	.	denotes	.
T9723	15387-15392	NN	denotes	Dmrt7
T9724	15396-15404	VBN	denotes	Required
T9725	15393-15395	VBZ	denotes	Is
T9726	15405-15408	IN	denotes	for
T9727	15409-15413	JJ	denotes	Male
T9728	15429-15442	NN	denotes	Gametogenesis
T9729	15414-15417	CC	denotes	but
T9730	15418-15421	RB	denotes	Not
T9731	15422-15428	JJ	denotes	Female
T9732	15442-15564	sentence	denotes	Breeding of Dmrt7 heterozygotes produced homozygous mutant progeny of both sexes at the expected frequency (63/264; 23%).
T9733	15443-15451	NN	denotes	Breeding
T9734	15475-15483	VBD	denotes	produced
T9735	15452-15454	IN	denotes	of
T9736	15455-15460	NN	denotes	Dmrt7
T9737	15461-15474	NNS	denotes	heterozygotes
T9738	15484-15494	JJ	denotes	homozygous
T9739	15502-15509	NN	denotes	progeny
T9740	15495-15501	NN	denotes	mutant
T9741	15510-15512	IN	denotes	of
T9742	15513-15517	DT	denotes	both
T9743	15518-15523	NNS	denotes	sexes
T9744	15524-15526	IN	denotes	at
T9745	15527-15530	DT	denotes	the
T9746	15540-15549	NN	denotes	frequency
T9747	15531-15539	VBN	denotes	expected
T9748	15550-15551	-LRB-	denotes	(
T9749	15561-15562	NN	denotes	%
T9750	15551-15553	CD	denotes	63
T9751	15554-15557	CD	denotes	264
T9752	15553-15554	SYM	denotes	/
T9753	15557-15558	:	denotes	;
T9754	15559-15561	CD	denotes	23
T9755	15562-15563	-RRB-	denotes	)
T9756	15563-15564	.	denotes	.
T9757	15564-15678	sentence	denotes	Male and female homozygous mutants were viable, grew to adulthood normally, and exhibited normal sexual behavior.
T9758	15565-15569	JJ	denotes	Male
T9759	15592-15599	NNS	denotes	mutants
T9760	15570-15573	CC	denotes	and
T9761	15574-15580	JJ	denotes	female
T9762	15581-15591	JJ	denotes	homozygous
T9763	15600-15604	VBD	denotes	were
T9764	15605-15611	JJ	denotes	viable
T9765	15611-15613	,	denotes	,
T9766	15613-15617	VBD	denotes	grew
T9767	15618-15620	IN	denotes	to
T9768	15621-15630	NN	denotes	adulthood
T9769	15631-15639	RB	denotes	normally
T9770	15639-15641	,	denotes	,
T9771	15641-15644	CC	denotes	and
T9772	15645-15654	VBD	denotes	exhibited
T9773	15655-15661	JJ	denotes	normal
T9774	15669-15677	NN	denotes	behavior
T9775	15662-15668	JJ	denotes	sexual
T9776	15677-15678	.	denotes	.
T9777	15678-15840	sentence	denotes	Female homozygotes were fertile, produced litters of normal size, and had no obvious ovarian abnormalities as judged by histological analysis (unpublished data).
T9778	15679-15685	JJ	denotes	Female
T9779	15686-15697	NNS	denotes	homozygotes
T9780	15698-15702	VBD	denotes	were
T9781	15703-15710	JJ	denotes	fertile
T9782	15710-15712	,	denotes	,
T9783	15712-15720	VBD	denotes	produced
T9784	15721-15728	NNS	denotes	litters
T9785	15729-15731	IN	denotes	of
T9786	15732-15738	JJ	denotes	normal
T9787	15739-15743	NN	denotes	size
T9788	15743-15745	,	denotes	,
T9789	15745-15748	CC	denotes	and
T9790	15749-15752	VBD	denotes	had
T9791	15753-15755	DT	denotes	no
T9792	15772-15785	NNS	denotes	abnormalities
T9793	15756-15763	JJ	denotes	obvious
T9794	15764-15771	JJ	denotes	ovarian
T9795	15786-15788	IN	denotes	as
T9796	15789-15795	VBN	denotes	judged
T9797	15796-15798	IN	denotes	by
T9798	15799-15811	JJ	denotes	histological
T9799	15812-15820	NN	denotes	analysis
T9800	15821-15822	-LRB-	denotes	(
T9801	15834-15838	NNS	denotes	data
T9802	15822-15833	JJ	denotes	unpublished
T9803	15838-15839	-RRB-	denotes	)
T9804	15839-15840	.	denotes	.
T9805	15840-16019	sentence	denotes	In contrast, Dmrt7 homozygous mutant males were completely infertile and had testes about one-third the weight of those of heterozygous or wild-type adult littermates (Figure 2).
T9806	15841-15843	IN	denotes	In
T9807	15884-15888	VBD	denotes	were
T9808	15844-15852	NN	denotes	contrast
T9809	15852-15854	,	denotes	,
T9810	15854-15859	NN	denotes	Dmrt7
T9811	15871-15877	NN	denotes	mutant
T9812	15860-15870	JJ	denotes	homozygous
T9813	15878-15883	NNS	denotes	males
T9814	15889-15899	RB	denotes	completely
T9815	15900-15909	JJ	denotes	infertile
T9816	15910-15913	CC	denotes	and
T9817	15914-15917	VBD	denotes	had
T9818	15918-15924	NNS	denotes	testes
T9819	15925-15930	IN	denotes	about
T9820	15931-15934	CD	denotes	one
T9821	15945-15951	NN	denotes	weight
T9822	15934-15935	HYPH	denotes	-
T9823	15935-15940	NN	denotes	third
T9824	15941-15944	DT	denotes	the
T9825	15952-15954	IN	denotes	of
T9826	15955-15960	DT	denotes	those
T9827	15961-15963	IN	denotes	of
T9828	15964-15976	JJ	denotes	heterozygous
T9829	15996-16007	NNS	denotes	littermates
T9830	15977-15979	CC	denotes	or
T9831	15980-15984	JJ	denotes	wild
T9832	15985-15989	NN	denotes	type
T9833	15984-15985	HYPH	denotes	-
T9834	15990-15995	JJ	denotes	adult
T9835	16008-16009	-LRB-	denotes	(
T9836	16009-16015	NN	denotes	Figure
T9837	16016-16017	CD	denotes	2
T9838	16017-16018	-RRB-	denotes	)
T9839	16018-16019	.	denotes	.
T9840	16019-16192	sentence	denotes	To determine when defective testis development begins in Dmrt7 mutants, we compared the testes of wild-type and mutant littermates during the first wave of spermatogenesis.
T9841	16020-16022	TO	denotes	To
T9842	16023-16032	VB	denotes	determine
T9843	16095-16103	VBD	denotes	compared
T9844	16033-16037	WRB	denotes	when
T9845	16067-16073	VBZ	denotes	begins
T9846	16038-16047	JJ	denotes	defective
T9847	16055-16066	NN	denotes	development
T9848	16048-16054	NN	denotes	testis
T9849	16074-16076	IN	denotes	in
T9850	16077-16082	NN	denotes	Dmrt7
T9851	16083-16090	NNS	denotes	mutants
T9852	16090-16092	,	denotes	,
T9853	16092-16094	PRP	denotes	we
T9854	16104-16107	DT	denotes	the
T9855	16108-16114	NNS	denotes	testes
T9856	16115-16117	IN	denotes	of
T9857	16118-16122	JJ	denotes	wild
T9858	16123-16127	NN	denotes	type
T9859	16122-16123	HYPH	denotes	-
T9860	16139-16150	NNS	denotes	littermates
T9861	16128-16131	CC	denotes	and
T9862	16132-16138	NN	denotes	mutant
T9863	16151-16157	IN	denotes	during
T9864	16158-16161	DT	denotes	the
T9865	16168-16172	NN	denotes	wave
T9866	16162-16167	JJ	denotes	first
T9867	16173-16175	IN	denotes	of
T9868	16176-16191	NN	denotes	spermatogenesis
T9869	16191-16192	.	denotes	.
T9870	16192-16462	sentence	denotes	Prior to postnatal day 14 (P14), mutant testes appeared histologically normal and the testis weights were similar to those of heterozygous and wild-type littermates, indicating that spermatogonia and early meiotic germ cells form normally (Figure 2B; unpublished data).
T9871	16193-16198	IN	denotes	Prior
T9872	16240-16248	VBD	denotes	appeared
T9873	16199-16201	IN	denotes	to
T9874	16202-16211	JJ	denotes	postnatal
T9875	16212-16215	NN	denotes	day
T9876	16216-16218	CD	denotes	14
T9877	16219-16220	-LRB-	denotes	(
T9878	16220-16223	NN	denotes	P14
T9879	16223-16224	-RRB-	denotes	)
T9880	16224-16226	,	denotes	,
T9881	16226-16232	NN	denotes	mutant
T9882	16233-16239	NNS	denotes	testes
T9883	16249-16263	RB	denotes	histologically
T9884	16264-16270	JJ	denotes	normal
T9885	16271-16274	CC	denotes	and
T9886	16275-16278	DT	denotes	the
T9887	16286-16293	NNS	denotes	weights
T9888	16279-16285	NN	denotes	testis
T9889	16294-16298	VBD	denotes	were
T9890	16299-16306	JJ	denotes	similar
T9891	16307-16309	IN	denotes	to
T9892	16310-16315	DT	denotes	those
T9893	16316-16318	IN	denotes	of
T9894	16319-16331	JJ	denotes	heterozygous
T9895	16346-16357	NNS	denotes	littermates
T9896	16332-16335	CC	denotes	and
T9897	16336-16340	JJ	denotes	wild
T9898	16341-16345	NN	denotes	type
T9899	16340-16341	HYPH	denotes	-
T9900	16357-16359	,	denotes	,
T9901	16359-16369	VBG	denotes	indicating
T9902	16370-16374	IN	denotes	that
T9903	16418-16422	VBP	denotes	form
T9904	16375-16388	NNS	denotes	spermatogonia
T9905	16389-16392	CC	denotes	and
T9906	16393-16398	JJ	denotes	early
T9907	16412-16417	NNS	denotes	cells
T9908	16399-16406	JJ	denotes	meiotic
T9909	16407-16411	NN	denotes	germ
T9910	16423-16431	RB	denotes	normally
T9911	16432-16433	-LRB-	denotes	(
T9912	16456-16460	NNS	denotes	data
T9913	16433-16439	NN	denotes	Figure
T9914	16440-16442	NN	denotes	2B
T9915	16442-16443	:	denotes	;
T9916	16444-16455	JJ	denotes	unpublished
T9917	16460-16461	-RRB-	denotes	)
T9918	16461-16462	.	denotes	.
T9919	16462-16568	sentence	denotes	Thereafter, the testes of the Dmrt7 mutant mice ceased to grow and the weight difference was significant.
T9920	16463-16473	RB	denotes	Thereafter
T9921	16511-16517	VBD	denotes	ceased
T9922	16473-16475	,	denotes	,
T9923	16475-16478	DT	denotes	the
T9924	16479-16485	NNS	denotes	testes
T9925	16486-16488	IN	denotes	of
T9926	16489-16492	DT	denotes	the
T9927	16506-16510	NNS	denotes	mice
T9928	16493-16498	NN	denotes	Dmrt7
T9929	16499-16505	NN	denotes	mutant
T9930	16518-16520	TO	denotes	to
T9931	16521-16525	VB	denotes	grow
T9932	16526-16529	CC	denotes	and
T9933	16530-16533	DT	denotes	the
T9934	16541-16551	NN	denotes	difference
T9935	16534-16540	NN	denotes	weight
T9936	16552-16555	VBD	denotes	was
T9937	16556-16567	JJ	denotes	significant
T9938	16567-16568	.	denotes	.
T9939	16568-16744	sentence	denotes	Microscopic examination of P21 and P42 Dmrt7 mutant testes revealed that germ cells arrest in pachynema, and later stages of germ cells are largely missing (Figure 2C and 2D).
T9940	16569-16580	JJ	denotes	Microscopic
T9941	16581-16592	NN	denotes	examination
T9942	16628-16636	VBD	denotes	revealed
T9943	16593-16595	IN	denotes	of
T9944	16596-16599	NN	denotes	P21
T9945	16621-16627	NNS	denotes	testes
T9946	16600-16603	CC	denotes	and
T9947	16604-16607	NN	denotes	P42
T9948	16608-16613	NN	denotes	Dmrt7
T9949	16614-16620	NN	denotes	mutant
T9950	16637-16641	IN	denotes	that
T9951	16653-16659	VBP	denotes	arrest
T9952	16642-16646	NN	denotes	germ
T9953	16647-16652	NNS	denotes	cells
T9954	16660-16662	IN	denotes	in
T9955	16663-16672	NN	denotes	pachynema
T9956	16672-16674	,	denotes	,
T9957	16674-16677	CC	denotes	and
T9958	16678-16683	JJ	denotes	later
T9959	16684-16690	NNS	denotes	stages
T9960	16705-16708	VBP	denotes	are
T9961	16691-16693	IN	denotes	of
T9962	16694-16698	NN	denotes	germ
T9963	16699-16704	NNS	denotes	cells
T9964	16709-16716	RB	denotes	largely
T9965	16717-16724	JJ	denotes	missing
T9966	16725-16726	-LRB-	denotes	(
T9967	16733-16735	NN	denotes	2C
T9968	16726-16732	NN	denotes	Figure
T9969	16736-16739	CC	denotes	and
T9970	16740-16742	NN	denotes	2D
T9971	16742-16743	-RRB-	denotes	)
T9972	16743-16744	.	denotes	.
T9973	16744-16894	sentence	denotes	Dmrt7 mutant mice are deficient in postmeiotic spermatids and lack epididymal spermatozoa, although a few cells develop to the round spermatid stage.
T9974	16745-16750	NN	denotes	Dmrt7
T9975	16751-16757	NN	denotes	mutant
T9976	16758-16762	NNS	denotes	mice
T9977	16763-16766	VBP	denotes	are
T9978	16767-16776	JJ	denotes	deficient
T9979	16777-16779	IN	denotes	in
T9980	16780-16791	JJ	denotes	postmeiotic
T9981	16792-16802	NNS	denotes	spermatids
T9982	16803-16806	CC	denotes	and
T9983	16807-16811	VBP	denotes	lack
T9984	16812-16822	JJ	denotes	epididymal
T9985	16823-16834	NNS	denotes	spermatozoa
T9986	16834-16836	,	denotes	,
T9987	16836-16844	IN	denotes	although
T9988	16857-16864	VBP	denotes	develop
T9989	16845-16846	DT	denotes	a
T9990	16851-16856	NNS	denotes	cells
T9991	16847-16850	JJ	denotes	few
T9992	16865-16867	IN	denotes	to
T9993	16868-16871	DT	denotes	the
T9994	16888-16893	NN	denotes	stage
T9995	16872-16877	JJ	denotes	round
T9996	16878-16887	NN	denotes	spermatid
T9997	16893-16894	.	denotes	.
T9998	16894-17000	sentence	denotes	These meiotic defects are in agreement with a recent preliminary analysis of another Dmrt7 mutation [42].
T9999	16895-16900	DT	denotes	These
T10000	16909-16916	NNS	denotes	defects
T10001	16901-16908	JJ	denotes	meiotic
T10002	16917-16920	VBP	denotes	are
T10003	16921-16923	IN	denotes	in
T10004	16924-16933	NN	denotes	agreement
T10005	16934-16938	IN	denotes	with
T10006	16939-16940	DT	denotes	a
T10007	16960-16968	NN	denotes	analysis
T10008	16941-16947	JJ	denotes	recent
T10009	16948-16959	JJ	denotes	preliminary
T10010	16969-16971	IN	denotes	of
T10011	16972-16979	DT	denotes	another
T10012	16986-16994	NN	denotes	mutation
T10013	16980-16985	NN	denotes	Dmrt7
T10014	16995-16996	-LRB-	denotes	[
T10015	16996-16998	CD	denotes	42
T10016	16998-16999	-RRB-	denotes	]
T10017	16999-17000	.	denotes	.
T10018	17000-17153	sentence	denotes	While some Dmrt7 mutant tubules are highly vacuolated and contain primarily Sertoli cells and spermatogonia, others have abundant primary spermatocytes.
T10019	17001-17006	IN	denotes	While
T10020	17033-17036	VBP	denotes	are
T10021	17007-17011	DT	denotes	some
T10022	17025-17032	NNS	denotes	tubules
T10023	17012-17017	NN	denotes	Dmrt7
T10024	17018-17024	NN	denotes	mutant
T10025	17117-17121	VBP	denotes	have
T10026	17037-17043	RB	denotes	highly
T10027	17044-17054	JJ	denotes	vacuolated
T10028	17055-17058	CC	denotes	and
T10029	17059-17066	VBP	denotes	contain
T10030	17067-17076	RB	denotes	primarily
T10031	17077-17084	NNP	denotes	Sertoli
T10032	17085-17090	NNS	denotes	cells
T10033	17091-17094	CC	denotes	and
T10034	17095-17108	NNS	denotes	spermatogonia
T10035	17108-17110	,	denotes	,
T10036	17110-17116	NNS	denotes	others
T10037	17122-17130	JJ	denotes	abundant
T10038	17139-17152	NNS	denotes	spermatocytes
T10039	17131-17138	JJ	denotes	primary
T10040	17152-17153	.	denotes	.
T10041	17153-17294	sentence	denotes	In addition, some tubules contain multinucleated cells and cells with darkly stained nuclei that are typical of apoptotic cells (Figure 2D).
T10042	17154-17156	IN	denotes	In
T10043	17180-17187	VBP	denotes	contain
T10044	17157-17165	NN	denotes	addition
T10045	17165-17167	,	denotes	,
T10046	17167-17171	DT	denotes	some
T10047	17172-17179	NNS	denotes	tubules
T10051	17213-17218	NNS	denotes	cells
T10052	17219-17223	IN	denotes	with
T10053	17224-17230	RB	denotes	darkly
T10054	17231-17238	VBN	denotes	stained
T10055	17239-17245	NNS	denotes	nuclei
T10056	17246-17250	WDT	denotes	that
T10057	17251-17254	VBP	denotes	are
T10058	17255-17262	JJ	denotes	typical
T10059	17263-17265	IN	denotes	of
T10060	17266-17275	JJ	denotes	apoptotic
T10061	17276-17281	NNS	denotes	cells
T10062	17282-17283	-LRB-	denotes	(
T10063	17290-17292	NN	denotes	2D
T10064	17283-17289	NN	denotes	Figure
T10065	17292-17293	-RRB-	denotes	)
T10066	17293-17294	.	denotes	.
T10067	17294-18455	sentence	denotes	Figure 2 Reduced Testis Size and Germ Cell Apoptosis in Mice with Targeted Deletion in Dmrt7 (A) Testes from a 6-wk-old wild-type (+/+) mouse and a homozygous (−/−) Dmrt7 mutant littermate. (B–D) Sections of testes from 14-d-old (B), 21-d-old (C), and 42-d-old mice (D) stained with hematoxylin and eosin. Wild-type is in left column and mutant in right. No significant difference is observed at 14 d (B), but by 21 d some tubules are lacking abundant spermatocytes (C, asterisk) or cells with typical apoptotic morphology are present (open arrowhead, C and D). Mutant tubules contain multinucleate cells (closed arrowhead, D). (E and F) TUNEL labeling of Dmrt7-deficient mouse testes. Testes from wild-type and homozygous mutant littermates were analyzed by TUNEL labeling to detect apoptotic cells. Testis sections from 21-d-old (E) and 6-wk-old mice (F). Apoptotic cells (brown) are much more abundant in seminiferous tubules of homozygous Dmrt7 mutant mice relative to wild-type. Bars in (B–F) represent 100 μm. Since Dmrt7 mutant testes lack most post-pachytene cells, we used TUNEL analysis to test whether the missing cells are eliminated by apoptosis.
T10068	18312-18317	IN	denotes	Since
T10069	18338-18342	VBP	denotes	lack
T10070	18318-18323	NN	denotes	Dmrt7
T10071	18331-18337	NNS	denotes	testes
T10072	18324-18330	NN	denotes	mutant
T10073	18373-18377	VBD	denotes	used
T10074	18343-18347	RBS	denotes	most
T10075	18363-18368	NNS	denotes	cells
T10076	18348-18362	JJ	denotes	post-pachytene
T10077	18368-18370	,	denotes	,
T10078	18370-18372	PRP	denotes	we
T10079	18378-18383	NN	denotes	TUNEL
T10080	18384-18392	NN	denotes	analysis
T10081	18393-18395	TO	denotes	to
T10082	18396-18400	VB	denotes	test
T10083	18401-18408	IN	denotes	whether
T10084	18431-18441	VBN	denotes	eliminated
T10085	18409-18412	DT	denotes	the
T10086	18421-18426	NNS	denotes	cells
T10087	18413-18420	JJ	denotes	missing
T10088	18427-18430	VBP	denotes	are
T10089	18442-18444	IN	denotes	by
T10090	18445-18454	NN	denotes	apoptosis
T10091	18454-18455	.	denotes	.
T10092	18455-18561	sentence	denotes	At 3 wk, Dmrt7 mutant testes contain significantly more apoptotic cells than those of wild-type controls.
T10093	18456-18458	IN	denotes	At
T10094	18485-18492	VBP	denotes	contain
T10095	18459-18460	CD	denotes	3
T10096	18461-18463	NNS	denotes	wk
T10097	18463-18465	,	denotes	,
T10098	18465-18470	NN	denotes	Dmrt7
T10099	18471-18477	NN	denotes	mutant
T10100	18478-18484	NNS	denotes	testes
T10101	18493-18506	RB	denotes	significantly
T10102	18507-18511	JJR	denotes	more
T10103	18522-18527	NNS	denotes	cells
T10104	18512-18521	JJ	denotes	apoptotic
T10105	18528-18532	IN	denotes	than
T10106	18533-18538	DT	denotes	those
T10107	18539-18541	IN	denotes	of
T10108	18542-18546	JJ	denotes	wild
T10109	18547-18551	NN	denotes	type
T10110	18546-18547	HYPH	denotes	-
T10111	18552-18560	NNS	denotes	controls
T10112	18560-18561	.	denotes	.
T10113	18561-18728	sentence	denotes	The percentage of tubule sections with five or more apoptotic nuclei was about three times higher in Dmrt7 mutants compared with wild-type (20% versus 7%; Figure 2E).
T10114	18562-18565	DT	denotes	The
T10115	18566-18576	NN	denotes	percentage
T10116	18631-18634	VBD	denotes	was
T10117	18577-18579	IN	denotes	of
T10118	18580-18586	NN	denotes	tubule
T10119	18587-18595	NNS	denotes	sections
T10120	18596-18600	IN	denotes	with
T10121	18601-18605	CD	denotes	five
T10122	18624-18630	NNS	denotes	nuclei
T10123	18606-18608	CC	denotes	or
T10124	18609-18613	JJR	denotes	more
T10125	18614-18623	JJ	denotes	apoptotic
T10126	18635-18640	IN	denotes	about
T10127	18641-18646	CD	denotes	three
T10128	18653-18659	JJR	denotes	higher
T10129	18647-18652	NNS	denotes	times
T10130	18660-18662	IN	denotes	in
T10131	18663-18668	NN	denotes	Dmrt7
T10132	18669-18676	NNS	denotes	mutants
T10133	18677-18685	VBN	denotes	compared
T10134	18686-18690	IN	denotes	with
T10135	18691-18695	JJ	denotes	wild
T10136	18696-18700	NN	denotes	type
T10137	18695-18696	HYPH	denotes	-
T10138	18701-18702	-LRB-	denotes	(
T10139	18724-18726	NN	denotes	2E
T10140	18702-18704	CD	denotes	20
T10141	18704-18705	NN	denotes	%
T10142	18706-18712	CC	denotes	versus
T10143	18713-18714	CD	denotes	7
T10144	18714-18715	NN	denotes	%
T10145	18715-18716	:	denotes	;
T10146	18717-18723	NN	denotes	Figure
T10147	18726-18727	-RRB-	denotes	)
T10148	18727-18728	.	denotes	.
T10149	18728-18812	sentence	denotes	A similar elevation of apoptosis was apparent in mutant testes at 7 wk (Figure 2F).
T10150	18729-18730	DT	denotes	A
T10151	18739-18748	NN	denotes	elevation
T10152	18731-18738	JJ	denotes	similar
T10153	18762-18765	VBD	denotes	was
T10154	18749-18751	IN	denotes	of
T10155	18752-18761	NN	denotes	apoptosis
T10156	18766-18774	JJ	denotes	apparent
T10157	18775-18777	IN	denotes	in
T10158	18778-18784	NN	denotes	mutant
T10159	18785-18791	NNS	denotes	testes
T10160	18792-18794	IN	denotes	at
T10161	18795-18796	CD	denotes	7
T10162	18797-18799	NNS	denotes	wk
T10163	18800-18801	-LRB-	denotes	(
T10164	18808-18810	NN	denotes	2F
T10165	18801-18807	NN	denotes	Figure
T10166	18810-18811	-RRB-	denotes	)
T10167	18811-18812	.	denotes	.
T10168	18812-18974	sentence	denotes	In mutants, many apoptotic cells were in the middle of the tubules, whereas the apoptotic cells in wild-type occur mainly near the seminiferous tubule periphery.
T10169	18813-18815	IN	denotes	In
T10170	18846-18850	VBD	denotes	were
T10171	18816-18823	NNS	denotes	mutants
T10172	18823-18825	,	denotes	,
T10173	18825-18829	JJ	denotes	many
T10174	18840-18845	NNS	denotes	cells
T10175	18830-18839	JJ	denotes	apoptotic
T10176	18851-18853	IN	denotes	in
T10177	18854-18857	DT	denotes	the
T10178	18858-18864	NN	denotes	middle
T10179	18865-18867	IN	denotes	of
T10180	18868-18871	DT	denotes	the
T10181	18872-18879	NNS	denotes	tubules
T10182	18879-18881	,	denotes	,
T10183	18881-18888	IN	denotes	whereas
T10184	18922-18927	VBP	denotes	occur
T10185	18889-18892	DT	denotes	the
T10186	18903-18908	NNS	denotes	cells
T10187	18893-18902	JJ	denotes	apoptotic
T10188	18909-18911	IN	denotes	in
T10189	18912-18916	JJ	denotes	wild
T10190	18917-18921	NN	denotes	type
T10191	18916-18917	HYPH	denotes	-
T10192	18928-18934	RB	denotes	mainly
T10193	18935-18939	IN	denotes	near
T10194	18940-18943	DT	denotes	the
T10195	18964-18973	NN	denotes	periphery
T10196	18944-18956	JJ	denotes	seminiferous
T10197	18957-18963	NN	denotes	tubule
T10198	18973-18974	.	denotes	.
T10199	18974-19160	sentence	denotes	The numbers of Sertoli cells were not significantly different between wild-type and mutant testes, and we observed no difference in somatic cell apoptosis in mutants (unpublished data).
T10200	18975-18978	DT	denotes	The
T10201	18979-18986	NNS	denotes	numbers
T10202	19004-19008	VBD	denotes	were
T10203	18987-18989	IN	denotes	of
T10204	18990-18997	NNP	denotes	Sertoli
T10205	18998-19003	NNS	denotes	cells
T10206	19009-19012	RB	denotes	not
T10207	19013-19026	RB	denotes	significantly
T10208	19027-19036	JJ	denotes	different
T10209	19037-19044	IN	denotes	between
T10210	19045-19049	JJ	denotes	wild
T10211	19050-19054	NN	denotes	type
T10212	19049-19050	HYPH	denotes	-
T10213	19066-19072	NNS	denotes	testes
T10214	19055-19058	CC	denotes	and
T10215	19059-19065	NN	denotes	mutant
T10216	19072-19074	,	denotes	,
T10217	19074-19077	CC	denotes	and
T10218	19078-19080	PRP	denotes	we
T10219	19081-19089	VBD	denotes	observed
T10220	19090-19092	DT	denotes	no
T10221	19093-19103	NN	denotes	difference
T10222	19104-19106	IN	denotes	in
T10223	19107-19114	JJ	denotes	somatic
T10224	19120-19129	NN	denotes	apoptosis
T10225	19115-19119	NN	denotes	cell
T10226	19130-19132	IN	denotes	in
T10227	19133-19140	NNS	denotes	mutants
T10228	19141-19142	-LRB-	denotes	(
T10229	19154-19158	NNS	denotes	data
T10230	19142-19153	JJ	denotes	unpublished
T10231	19158-19159	-RRB-	denotes	)
T10232	19159-19160	.	denotes	.
T10233	19160-19336	sentence	denotes	From these results, we conclude that loss of Dmrt7 causes a block in meiotic progression, mainly in pachynema, leading to the elimination, by apoptosis, of the arrested cells.
T10234	19161-19165	IN	denotes	From
T10235	19184-19192	VBP	denotes	conclude
T10236	19166-19171	DT	denotes	these
T10237	19172-19179	NNS	denotes	results
T10238	19179-19181	,	denotes	,
T10239	19181-19183	PRP	denotes	we
T10240	19193-19197	IN	denotes	that
T10241	19212-19218	VBZ	denotes	causes
T10242	19198-19202	NN	denotes	loss
T10243	19203-19205	IN	denotes	of
T10244	19206-19211	NN	denotes	Dmrt7
T10245	19219-19220	DT	denotes	a
T10246	19221-19226	NN	denotes	block
T10247	19227-19229	IN	denotes	in
T10248	19230-19237	JJ	denotes	meiotic
T10249	19238-19249	NN	denotes	progression
T10250	19249-19251	,	denotes	,
T10251	19251-19257	RB	denotes	mainly
T10252	19258-19260	IN	denotes	in
T10253	19261-19270	NN	denotes	pachynema
T10254	19270-19272	,	denotes	,
T10255	19272-19279	VBG	denotes	leading
T10256	19280-19282	IN	denotes	to
T10257	19283-19286	DT	denotes	the
T10258	19287-19298	NN	denotes	elimination
T10259	19298-19300	,	denotes	,
T10260	19300-19302	IN	denotes	by
T10261	19303-19312	NN	denotes	apoptosis
T10262	19312-19314	,	denotes	,
T10263	19314-19316	IN	denotes	of
T10264	19317-19320	DT	denotes	the
T10265	19330-19335	NNS	denotes	cells
T10266	19321-19329	VBN	denotes	arrested
T10267	19335-19336	.	denotes	.
T10982	19528-19532	NN	denotes	cell
T10983	19540-19541	.	denotes	.
T10945	19338-19347	NN	denotes	Pachytene
T10946	19348-19354	NN	denotes	Arrest
T10947	19355-19357	IN	denotes	of
T10948	19358-19363	NN	denotes	Dmrt7
T10949	19364-19370	NN	denotes	Mutant
T10950	19376-19381	NNS	denotes	Cells
T10951	19371-19375	NN	denotes	Germ
T10952	19381-19541	sentence	denotes	To better define the spermatogenic stage at which Dmrt7−/− male germ cells arrest and die, we used antibodies against several stage-specific germ cell markers.
T10953	19382-19384	TO	denotes	To
T10954	19392-19398	VB	denotes	define
T10955	19385-19391	RBR	denotes	better
T10956	19476-19480	VBD	denotes	used
T10957	19399-19402	DT	denotes	the
T10958	19417-19422	NN	denotes	stage
T10959	19403-19416	JJ	denotes	spermatogenic
T10960	19423-19425	IN	denotes	at
T10961	19457-19463	VBP	denotes	arrest
T10962	19426-19431	WDT	denotes	which
T10963	19432-19437	NN	denotes	Dmrt7
T10964	19451-19456	NNS	denotes	cells
T10965	19437-19438	SYM	denotes	−
T10966	19438-19439	HYPH	denotes	/
T10967	19439-19440	SYM	denotes	−
T10968	19441-19445	JJ	denotes	male
T10969	19446-19450	NN	denotes	germ
T10970	19464-19467	CC	denotes	and
T10971	19468-19471	VBP	denotes	die
T10972	19471-19473	,	denotes	,
T10973	19473-19475	PRP	denotes	we
T10974	19481-19491	NNS	denotes	antibodies
T10975	19492-19499	IN	denotes	against
T10976	19500-19507	JJ	denotes	several
T10977	19533-19540	NNS	denotes	markers
T10978	19508-19513	NN	denotes	stage
T10979	19514-19522	JJ	denotes	specific
T10980	19513-19514	HYPH	denotes	-
T10981	19523-19527	NN	denotes	germ
T10984	19541-19592	sentence	denotes	TRA98 is expressed in PGCs and spermatogonia [43].
T10985	19542-19547	NN	denotes	TRA98
T10986	19551-19560	VBN	denotes	expressed
T10987	19548-19550	VBZ	denotes	is
T10988	19561-19563	IN	denotes	in
T10989	19564-19568	NNS	denotes	PGCs
T10990	19569-19572	CC	denotes	and
T10991	19573-19586	NNS	denotes	spermatogonia
T10992	19587-19588	-LRB-	denotes	[
T10993	19588-19590	CD	denotes	43
T10994	19590-19591	-RRB-	denotes	]
T10995	19591-19592	.	denotes	.
T10996	19592-19832	sentence	denotes	In the wild-type adult testis, strongly staining TRA98-positive cells form a layer one cell deep; however, in the mutant TRA98, strongly positive cells were abnormally organized, and some tubules had a layer several cells deep (Figure 3A).
T10997	19593-19595	IN	denotes	In
T10998	19663-19667	VBP	denotes	form
T10999	19596-19599	DT	denotes	the
T11000	19616-19622	NN	denotes	testis
T11001	19600-19604	JJ	denotes	wild
T11002	19605-19609	NN	denotes	type
T11003	19604-19605	HYPH	denotes	-
T11004	19610-19615	JJ	denotes	adult
T11005	19622-19624	,	denotes	,
T11006	19624-19632	RB	denotes	strongly
T11007	19633-19641	VBG	denotes	staining
T11008	19657-19662	NNS	denotes	cells
T11009	19642-19647	NN	denotes	TRA98
T11010	19648-19656	JJ	denotes	positive
T11011	19647-19648	HYPH	denotes	-
T11012	19745-19749	VBD	denotes	were
T11013	19668-19669	DT	denotes	a
T11014	19670-19675	NN	denotes	layer
T11015	19676-19679	CD	denotes	one
T11016	19680-19684	NN	denotes	cell
T11017	19685-19689	JJ	denotes	deep
T11018	19689-19690	:	denotes	;
T11019	19691-19698	RB	denotes	however
T11020	19698-19700	,	denotes	,
T11021	19700-19702	IN	denotes	in
T11022	19703-19706	DT	denotes	the
T11023	19714-19719	NN	denotes	TRA98
T11024	19707-19713	NN	denotes	mutant
T11025	19719-19721	,	denotes	,
T11026	19721-19729	RB	denotes	strongly
T11027	19730-19738	JJ	denotes	positive
T11028	19739-19744	NNS	denotes	cells
T11029	19750-19760	RB	denotes	abnormally
T11030	19761-19770	JJ	denotes	organized
T11031	19770-19772	,	denotes	,
T11032	19772-19775	CC	denotes	and
T11033	19776-19780	DT	denotes	some
T11034	19781-19788	NNS	denotes	tubules
T11035	19789-19792	VBD	denotes	had
T11036	19793-19794	DT	denotes	a
T11037	19795-19800	NN	denotes	layer
T11038	19801-19808	JJ	denotes	several
T11039	19809-19814	NNS	denotes	cells
T11040	19815-19819	JJ	denotes	deep
T11041	19820-19821	-LRB-	denotes	(
T11042	19828-19830	NN	denotes	3A
T11043	19821-19827	NN	denotes	Figure
T11044	19830-19831	-RRB-	denotes	)
T11045	19831-19832	.	denotes	.
T11046	19832-19923	sentence	denotes	The BC7 antibody recognizes spermatocytes in the leptotene to early-pachytene stages [44].
T11047	19833-19836	DT	denotes	The
T11048	19841-19849	NN	denotes	antibody
T11049	19837-19840	NN	denotes	BC7
T11050	19850-19860	VBZ	denotes	recognizes
T11051	19861-19874	NNS	denotes	spermatocytes
T11052	19875-19877	IN	denotes	in
T11053	19878-19881	DT	denotes	the
T11054	19882-19891	NN	denotes	leptotene
T11055	19892-19894	IN	denotes	to
T11056	19895-19900	JJ	denotes	early
T11057	19901-19910	NN	denotes	pachytene
T11058	19900-19901	HYPH	denotes	-
T11059	19911-19917	NNS	denotes	stages
T11060	19918-19919	-LRB-	denotes	[
T11061	19919-19921	CD	denotes	44
T11062	19921-19922	-RRB-	denotes	]
T11063	19922-19923	.	denotes	.
T11064	19923-20124	sentence	denotes	Dmrt7 mutant testes had BC7-positive cells in approximately normal numbers, but again abnormally organized, with many positive cells in the center rather than the periphery of the tubules (Figure 3B).
T11065	19924-19929	NN	denotes	Dmrt7
T11066	19930-19936	NN	denotes	mutant
T11067	19937-19943	NNS	denotes	testes
T11068	19944-19947	VBD	denotes	had
T11069	19948-19951	NN	denotes	BC7
T11070	19952-19960	JJ	denotes	positive
T11071	19951-19952	HYPH	denotes	-
T11072	19961-19966	NNS	denotes	cells
T11073	19967-19969	IN	denotes	in
T11074	19970-19983	RB	denotes	approximately
T11075	19984-19990	JJ	denotes	normal
T11076	19991-19998	NNS	denotes	numbers
T11077	19998-20000	,	denotes	,
T11078	20000-20003	CC	denotes	but
T11079	20004-20009	RB	denotes	again
T11080	20021-20030	VBN	denotes	organized
T11081	20010-20020	RB	denotes	abnormally
T11082	20030-20032	,	denotes	,
T11083	20032-20036	IN	denotes	with
T11084	20037-20041	JJ	denotes	many
T11085	20051-20056	NNS	denotes	cells
T11086	20042-20050	JJ	denotes	positive
T11087	20057-20059	IN	denotes	in
T11088	20060-20063	DT	denotes	the
T11089	20064-20070	NN	denotes	center
T11090	20071-20077	RB	denotes	rather
T11091	20078-20082	IN	denotes	than
T11092	20083-20086	DT	denotes	the
T11093	20087-20096	NN	denotes	periphery
T11094	20097-20099	IN	denotes	of
T11095	20100-20103	DT	denotes	the
T11096	20104-20111	NNS	denotes	tubules
T11097	20112-20113	-LRB-	denotes	(
T11098	20120-20122	NN	denotes	3B
T11099	20113-20119	NN	denotes	Figure
T11100	20122-20123	-RRB-	denotes	)
T11101	20123-20124	.	denotes	.
T11102	20124-20246	sentence	denotes	The TRA369 antibody recognizes a calmegin protein expressed in pachytene spermatocytes through elongated spermatids [45].
T11103	20125-20128	DT	denotes	The
T11104	20136-20144	NN	denotes	antibody
T11105	20129-20135	NN	denotes	TRA369
T11106	20145-20155	VBZ	denotes	recognizes
T11107	20156-20157	DT	denotes	a
T11108	20167-20174	NN	denotes	protein
T11109	20158-20166	NN	denotes	calmegin
T11110	20175-20184	VBN	denotes	expressed
T11111	20185-20187	IN	denotes	in
T11112	20188-20197	NN	denotes	pachytene
T11113	20198-20211	NNS	denotes	spermatocytes
T11114	20212-20219	IN	denotes	through
T11115	20220-20229	VBN	denotes	elongated
T11116	20230-20240	NNS	denotes	spermatids
T11117	20241-20242	-LRB-	denotes	[
T11118	20242-20244	CD	denotes	45
T11119	20244-20245	-RRB-	denotes	]
T11120	20245-20246	.	denotes	.
T11121	20246-20378	sentence	denotes	In contrast to the earlier stages, far fewer TRA369-positive cells were present in mutant testes relative to wild-type (Figure 3C).
T11122	20247-20249	IN	denotes	In
T11123	20314-20318	VBD	denotes	were
T11124	20250-20258	NN	denotes	contrast
T11125	20259-20261	IN	denotes	to
T11126	20262-20265	DT	denotes	the
T11127	20274-20280	NNS	denotes	stages
T11128	20266-20273	JJR	denotes	earlier
T11129	20280-20282	,	denotes	,
T11130	20282-20285	RB	denotes	far
T11131	20286-20291	JJR	denotes	fewer
T11132	20308-20313	NNS	denotes	cells
T11133	20292-20298	NN	denotes	TRA369
T11134	20299-20307	JJ	denotes	positive
T11135	20298-20299	HYPH	denotes	-
T11136	20319-20326	JJ	denotes	present
T11137	20327-20329	IN	denotes	in
T11138	20330-20336	NN	denotes	mutant
T11139	20337-20343	NNS	denotes	testes
T11140	20344-20352	JJ	denotes	relative
T11141	20353-20355	IN	denotes	to
T11142	20356-20360	JJ	denotes	wild
T11143	20361-20365	NN	denotes	type
T11144	20360-20361	HYPH	denotes	-
T11145	20366-20367	-LRB-	denotes	(
T11146	20374-20376	NN	denotes	3C
T11147	20367-20373	NN	denotes	Figure
T11148	20376-20377	-RRB-	denotes	)
T11149	20377-20378	.	denotes	.
T11150	20378-20578	sentence	denotes	We also quantitated the number of cells at each meiotic stage using spermatocyte spreads, assaying chromosome-pairing status by staining for SYCP3, a component of the synaptonemal complex (Figure 4).
T11151	20379-20381	PRP	denotes	We
T11152	20387-20398	VBD	denotes	quantitated
T11153	20382-20386	RB	denotes	also
T11154	20399-20402	DT	denotes	the
T11155	20403-20409	NN	denotes	number
T11156	20410-20412	IN	denotes	of
T11157	20413-20418	NNS	denotes	cells
T11158	20419-20421	IN	denotes	at
T11159	20422-20426	DT	denotes	each
T11160	20435-20440	NN	denotes	stage
T11161	20427-20434	JJ	denotes	meiotic
T11162	20441-20446	VBG	denotes	using
T11163	20447-20459	NN	denotes	spermatocyte
T11164	20460-20467	NNS	denotes	spreads
T11165	20467-20469	,	denotes	,
T11166	20469-20477	VBG	denotes	assaying
T11167	20478-20488	NN	denotes	chromosome
T11168	20489-20496	VBG	denotes	pairing
T11169	20488-20489	HYPH	denotes	-
T11170	20497-20503	NN	denotes	status
T11171	20504-20506	IN	denotes	by
T11172	20507-20515	VBG	denotes	staining
T11173	20516-20519	IN	denotes	for
T11174	20520-20525	NN	denotes	SYCP3
T11175	20525-20527	,	denotes	,
T11176	20527-20528	DT	denotes	a
T11177	20529-20538	NN	denotes	component
T11178	20539-20541	IN	denotes	of
T11179	20542-20545	DT	denotes	the
T11180	20559-20566	NN	denotes	complex
T11181	20546-20558	JJ	denotes	synaptonemal
T11182	20567-20568	-LRB-	denotes	(
T11183	20568-20574	NN	denotes	Figure
T11184	20575-20576	CD	denotes	4
T11185	20576-20577	-RRB-	denotes	)
T11186	20577-20578	.	denotes	.
T11187	20578-20705	sentence	denotes	We found that Dmrt7 mutants accumulate pachytene cells but have greatly reduced numbers of cells in late-pachynema and beyond.
T11188	20579-20581	PRP	denotes	We
T11189	20582-20587	VBD	denotes	found
T11190	20588-20592	IN	denotes	that
T11191	20607-20617	VBP	denotes	accumulate
T11192	20593-20598	NN	denotes	Dmrt7
T11193	20599-20606	NNS	denotes	mutants
T11194	20618-20627	NN	denotes	pachytene
T11195	20628-20633	NNS	denotes	cells
T11196	20634-20637	CC	denotes	but
T11197	20638-20642	VBP	denotes	have
T11198	20643-20650	RB	denotes	greatly
T11199	20651-20658	VBN	denotes	reduced
T11200	20659-20666	NNS	denotes	numbers
T11201	20667-20669	IN	denotes	of
T11202	20670-20675	NNS	denotes	cells
T11203	20676-20678	IN	denotes	in
T11204	20679-20683	JJ	denotes	late
T11205	20684-20693	NN	denotes	pachynema
T11206	20683-20684	HYPH	denotes	-
T11207	20694-20697	CC	denotes	and
T11208	20698-20704	RB	denotes	beyond
T11209	20704-20705	.	denotes	.
T11210	20705-20868	sentence	denotes	Together, these results confirm that the meiotic arrest in Dmrt7 mutants occurs primarily during pachynema and results in efficient elimination of arrested cells.
T11211	20706-20714	RB	denotes	Together
T11212	20730-20737	VBP	denotes	confirm
T11213	20714-20716	,	denotes	,
T11214	20716-20721	DT	denotes	these
T11215	20722-20729	NNS	denotes	results
T11216	20738-20742	IN	denotes	that
T11217	20779-20785	VBZ	denotes	occurs
T11218	20743-20746	DT	denotes	the
T11219	20755-20761	NN	denotes	arrest
T11220	20747-20754	JJ	denotes	meiotic
T11221	20762-20764	IN	denotes	in
T11222	20765-20770	NN	denotes	Dmrt7
T11223	20771-20778	NNS	denotes	mutants
T11224	20786-20795	RB	denotes	primarily
T11225	20796-20802	IN	denotes	during
T11226	20803-20812	NN	denotes	pachynema
T11227	20813-20816	CC	denotes	and
T11228	20817-20824	VBZ	denotes	results
T11229	20825-20827	IN	denotes	in
T11230	20828-20837	JJ	denotes	efficient
T11231	20838-20849	NN	denotes	elimination
T11232	20850-20852	IN	denotes	of
T11233	20853-20861	VBN	denotes	arrested
T11234	20862-20867	NNS	denotes	cells
T11235	20867-20868	.	denotes	.
T11839	22046-22053	NN	denotes	element
T11774	21683-21689	JJ	denotes	Normal
T11775	21698-21706	NN	denotes	Prophase
T11776	21690-21697	JJ	denotes	Meiotic
T11777	21707-21709	IN	denotes	in
T11778	21710-21715	NN	denotes	Dmrt7
T11779	21716-21722	NN	denotes	Mutant
T11780	21728-21733	NNS	denotes	Cells
T11781	21723-21727	NN	denotes	Germ
T11782	21733-21840	sentence	denotes	Defects in chromosome pairing, synapsis, or recombination can trigger pachytene arrest and apoptosis [46].
T11783	21734-21741	NNS	denotes	Defects
T11784	21796-21803	VB	denotes	trigger
T11785	21742-21744	IN	denotes	in
T11786	21745-21755	NN	denotes	chromosome
T11787	21756-21763	NN	denotes	pairing
T11788	21763-21765	,	denotes	,
T11789	21765-21773	NN	denotes	synapsis
T11790	21773-21775	,	denotes	,
T11791	21775-21777	CC	denotes	or
T11792	21778-21791	NN	denotes	recombination
T11793	21792-21795	MD	denotes	can
T11794	21804-21813	NN	denotes	pachytene
T11795	21814-21820	NN	denotes	arrest
T11796	21821-21824	CC	denotes	and
T11797	21825-21834	NN	denotes	apoptosis
T11798	21835-21836	-LRB-	denotes	[
T11799	21836-21838	CD	denotes	46
T11800	21838-21839	-RRB-	denotes	]
T11801	21839-21840	.	denotes	.
T11802	21840-21899	sentence	denotes	We therefore examined these events in Dmrt7 mutant testes.
T11803	21841-21843	PRP	denotes	We
T11804	21854-21862	VBD	denotes	examined
T11805	21844-21853	RB	denotes	therefore
T11806	21863-21868	DT	denotes	these
T11807	21869-21875	NNS	denotes	events
T11808	21876-21878	IN	denotes	in
T11809	21879-21884	NN	denotes	Dmrt7
T11810	21885-21891	NN	denotes	mutant
T11811	21892-21898	NNS	denotes	testes
T11812	21898-21899	.	denotes	.
T11813	21899-22117	sentence	denotes	To assess homolog synapsis, we used antibodies to SYCP1, a synaptonemal complex transverse element component, and SYCP3, a component of the axial element, which remains on the desynapsed axes during diplonema [47,48].
T11814	21900-21902	TO	denotes	To
T11815	21903-21909	VB	denotes	assess
T11816	21931-21935	VBD	denotes	used
T11817	21910-21917	NN	denotes	homolog
T11818	21918-21926	NN	denotes	synapsis
T11819	21926-21928	,	denotes	,
T11820	21928-21930	PRP	denotes	we
T11821	21936-21946	NNS	denotes	antibodies
T11822	21947-21949	IN	denotes	to
T11823	21950-21955	NN	denotes	SYCP1
T11824	21955-21957	,	denotes	,
T11825	21957-21958	DT	denotes	a
T11826	21999-22008	NN	denotes	component
T11827	21959-21971	JJ	denotes	synaptonemal
T11828	21972-21979	NN	denotes	complex
T11829	21980-21990	NN	denotes	transverse
T11830	21991-21998	NN	denotes	element
T11831	22008-22010	,	denotes	,
T11832	22010-22013	CC	denotes	and
T11833	22014-22019	NN	denotes	SYCP3
T11834	22019-22021	,	denotes	,
T11835	22021-22022	DT	denotes	a
T11836	22023-22032	NN	denotes	component
T11837	22033-22035	IN	denotes	of
T11838	22036-22039	DT	denotes	the
T11840	22040-22045	JJ	denotes	axial
T11841	22053-22055	,	denotes	,
T11842	22055-22060	WDT	denotes	which
T11843	22061-22068	VBZ	denotes	remains
T11844	22069-22071	IN	denotes	on
T11845	22072-22075	DT	denotes	the
T11846	22087-22091	NNS	denotes	axes
T11847	22076-22086	VBN	denotes	desynapsed
T11848	22092-22098	IN	denotes	during
T11849	22099-22108	NN	denotes	diplonema
T11850	22109-22110	-LRB-	denotes	[
T11851	22113-22115	CD	denotes	48
T11852	22110-22112	CD	denotes	47
T11853	22112-22113	,	denotes	,
T11854	22115-22116	-RRB-	denotes	]
T11855	22116-22117	.	denotes	.
T11856	22117-22304	sentence	denotes	Formation of synaptonemal complexes in the mutant was indistinguishable from that in wild-type, as indicated by the proper accumulation of SYCP1 (unpublished data) and SYCP3 (Figure 5A).
T11857	22118-22127	NN	denotes	Formation
T11858	22168-22171	VBD	denotes	was
T11859	22128-22130	IN	denotes	of
T11860	22131-22143	JJ	denotes	synaptonemal
T11861	22144-22153	NNS	denotes	complexes
T11862	22154-22156	IN	denotes	in
T11863	22157-22160	DT	denotes	the
T11864	22161-22167	NN	denotes	mutant
T11865	22172-22189	JJ	denotes	indistinguishable
T11866	22190-22194	IN	denotes	from
T11867	22195-22199	DT	denotes	that
T11868	22200-22202	IN	denotes	in
T11869	22203-22207	JJ	denotes	wild
T11870	22208-22212	NN	denotes	type
T11871	22207-22208	HYPH	denotes	-
T11872	22212-22214	,	denotes	,
T11873	22214-22216	IN	denotes	as
T11874	22217-22226	VBN	denotes	indicated
T11875	22227-22229	IN	denotes	by
T11876	22230-22233	DT	denotes	the
T11877	22241-22253	NN	denotes	accumulation
T11878	22234-22240	JJ	denotes	proper
T11879	22254-22256	IN	denotes	of
T11880	22257-22262	NN	denotes	SYCP1
T11881	22263-22264	-LRB-	denotes	(
T11882	22276-22280	NNS	denotes	data
T11883	22264-22275	JJ	denotes	unpublished
T11884	22280-22281	-RRB-	denotes	)
T11885	22282-22285	CC	denotes	and
T11886	22286-22291	NN	denotes	SYCP3
T11887	22292-22293	-LRB-	denotes	(
T11888	22300-22302	NN	denotes	5A
T11889	22293-22299	NN	denotes	Figure
T11890	22302-22303	-RRB-	denotes	)
T11891	22303-22304	.	denotes	.
T11892	22304-22516	sentence	denotes	Likewise, the Dmrt7 mutant zygotene spermatocytes showed normal accumulation of the early recombination repair marker RAD51, suggesting that early meiotic recombination is not significantly affected (Figure 5B).
T11893	22305-22313	RB	denotes	Likewise
T11894	22355-22361	VBD	denotes	showed
T11895	22313-22315	,	denotes	,
T11896	22315-22318	DT	denotes	the
T11897	22341-22354	NNS	denotes	spermatocytes
T11898	22319-22324	NN	denotes	Dmrt7
T11899	22325-22331	NN	denotes	mutant
T11900	22332-22340	NN	denotes	zygotene
T11901	22362-22368	JJ	denotes	normal
T11902	22369-22381	NN	denotes	accumulation
T11903	22382-22384	IN	denotes	of
T11904	22385-22388	DT	denotes	the
T11905	22423-22428	NN	denotes	RAD51
T11906	22389-22394	JJ	denotes	early
T11907	22395-22408	NN	denotes	recombination
T11908	22409-22415	NN	denotes	repair
T11909	22416-22422	NN	denotes	marker
T11910	22428-22430	,	denotes	,
T11911	22430-22440	VBG	denotes	suggesting
T11912	22441-22445	IN	denotes	that
T11913	22495-22503	VBN	denotes	affected
T11914	22446-22451	JJ	denotes	early
T11915	22460-22473	NN	denotes	recombination
T11916	22452-22459	JJ	denotes	meiotic
T11917	22474-22476	VBZ	denotes	is
T11918	22477-22480	RB	denotes	not
T11919	22481-22494	RB	denotes	significantly
T11920	22504-22505	-LRB-	denotes	(
T11921	22512-22514	NN	denotes	5B
T11922	22505-22511	NN	denotes	Figure
T11923	22514-22515	-RRB-	denotes	)
T11924	22515-22516	.	denotes	.
T11925	22516-22693	sentence	denotes	Dmrt7 mutant spermatocytes exhibited the expected decline in the presence of RAD51 foci associated with the autosomal synaptonemal complexes (Figure 5B; unpublished data) [49].
T11926	22517-22522	NN	denotes	Dmrt7
T11927	22523-22529	NN	denotes	mutant
T11928	22530-22543	NNS	denotes	spermatocytes
T11929	22544-22553	VBD	denotes	exhibited
T11930	22554-22557	DT	denotes	the
T11931	22567-22574	NN	denotes	decline
T11932	22558-22566	VBN	denotes	expected
T11933	22575-22577	IN	denotes	in
T11934	22578-22581	DT	denotes	the
T11935	22582-22590	NN	denotes	presence
T11936	22591-22593	IN	denotes	of
T11937	22594-22599	NN	denotes	RAD51
T11938	22600-22604	NNS	denotes	foci
T11939	22605-22615	VBN	denotes	associated
T11940	22616-22620	IN	denotes	with
T11941	22621-22624	DT	denotes	the
T11942	22648-22657	NNS	denotes	complexes
T11943	22625-22634	JJ	denotes	autosomal
T11944	22635-22647	JJ	denotes	synaptonemal
T11945	22658-22659	-LRB-	denotes	(
T11946	22682-22686	NNS	denotes	data
T11947	22659-22665	NN	denotes	Figure
T11948	22666-22668	NN	denotes	5B
T11949	22668-22669	:	denotes	;
T11950	22670-22681	JJ	denotes	unpublished
T11951	22686-22687	-RRB-	denotes	)
T11952	22688-22689	-LRB-	denotes	[
T11953	22689-22691	CD	denotes	49
T11954	22691-22692	-RRB-	denotes	]
T11955	22692-22693	.	denotes	.
T11956	22693-22824	sentence	denotes	The few surviving cells that progressed beyond pachynema also underwent apparently normal desynapsis during diplonema (Figure 5A).
T11957	22694-22697	DT	denotes	The
T11958	22712-22717	NNS	denotes	cells
T11959	22698-22701	JJ	denotes	few
T11960	22702-22711	VBG	denotes	surviving
T11961	22756-22765	VBD	denotes	underwent
T11962	22718-22722	WDT	denotes	that
T11963	22723-22733	VBD	denotes	progressed
T11964	22734-22740	IN	denotes	beyond
T11965	22741-22750	NN	denotes	pachynema
T11966	22751-22755	RB	denotes	also
T11967	22766-22776	RB	denotes	apparently
T11968	22777-22783	JJ	denotes	normal
T11969	22784-22794	NN	denotes	desynapsis
T11970	22795-22801	IN	denotes	during
T11971	22802-22811	NN	denotes	diplonema
T11972	22812-22813	-LRB-	denotes	(
T11973	22820-22822	NN	denotes	5A
T11974	22813-22819	NN	denotes	Figure
T11975	22822-22823	-RRB-	denotes	)
T11976	22823-22824	.	denotes	.
T11977	22824-22982	sentence	denotes	From these results, we conclude that chromosomal pairing, synapsis, recombination, and desynapsis during prophase I in Dmrt7 mutant males are grossly normal.
T11978	22825-22829	IN	denotes	From
T11979	22848-22856	VBP	denotes	conclude
T11980	22830-22835	DT	denotes	these
T11981	22836-22843	NNS	denotes	results
T11982	22843-22845	,	denotes	,
T11983	22845-22847	PRP	denotes	we
T11984	22857-22861	IN	denotes	that
T11985	22963-22966	VBP	denotes	are
T11986	22862-22873	JJ	denotes	chromosomal
T11987	22874-22881	NN	denotes	pairing
T11988	22881-22883	,	denotes	,
T11989	22883-22891	NN	denotes	synapsis
T11990	22891-22893	,	denotes	,
T11991	22893-22906	NN	denotes	recombination
T11992	22906-22908	,	denotes	,
T11993	22908-22911	CC	denotes	and
T11994	22912-22922	NN	denotes	desynapsis
T11995	22923-22929	IN	denotes	during
T11996	22930-22938	NN	denotes	prophase
T11997	22939-22940	CD	denotes	I
T11998	22941-22943	IN	denotes	in
T11999	22944-22949	NN	denotes	Dmrt7
T12000	22950-22956	NN	denotes	mutant
T12001	22957-22962	NNS	denotes	males
T12002	22967-22974	RB	denotes	grossly
T12003	22975-22981	JJ	denotes	normal
T12004	22981-22982	.	denotes	.
T21791	38132-38145	NN	denotes	recombination
T21792	38153-38159	JJ	denotes	normal
T13075	23653-23661	JJ	denotes	Abnormal
T13076	23671-23683	NN	denotes	Organization
T13077	23662-23670	JJ	denotes	Cellular
T13078	23684-23687	CC	denotes	and
T13079	23688-23691	DT	denotes	the
T13080	23692-23696	NN	denotes	Role
T13081	23697-23699	IN	denotes	of
T13082	23700-23707	NNP	denotes	Sertoli
T13083	23708-23713	NNS	denotes	Cells
T13084	23713-23838	sentence	denotes	Sertoli cells interact with germ cells during spermatogenesis and the interaction is critical for germ cell maturation [50].
T13085	23714-23721	NNP	denotes	Sertoli
T13086	23722-23727	NNS	denotes	cells
T13087	23728-23736	VBP	denotes	interact
T13088	23737-23741	IN	denotes	with
T13089	23742-23746	NN	denotes	germ
T13090	23747-23752	NNS	denotes	cells
T13091	23753-23759	IN	denotes	during
T13092	23760-23775	NN	denotes	spermatogenesis
T13093	23776-23779	CC	denotes	and
T13094	23780-23783	DT	denotes	the
T13095	23784-23795	NN	denotes	interaction
T13096	23796-23798	VBZ	denotes	is
T13097	23799-23807	JJ	denotes	critical
T13098	23808-23811	IN	denotes	for
T13099	23812-23816	NN	denotes	germ
T13100	23817-23821	NN	denotes	cell
T13101	23822-23832	NN	denotes	maturation
T13102	23833-23834	-LRB-	denotes	[
T13103	23834-23836	CD	denotes	50
T13104	23836-23837	-RRB-	denotes	]
T13105	23837-23838	.	denotes	.
T13106	23838-24064	sentence	denotes	Although we did not detect DMRT7 expression in Sertoli cells by antibody staining, we nevertheless considered the possibility that Sertoli cell defects might contribute to the male-specific germ line failure of Dmrt7 mutants.
T13107	23839-23847	IN	denotes	Although
T13108	23859-23865	VB	denotes	detect
T13109	23848-23850	PRP	denotes	we
T13110	23851-23854	VBD	denotes	did
T13111	23855-23858	RB	denotes	not
T13112	23938-23948	VBD	denotes	considered
T13113	23866-23871	NN	denotes	DMRT7
T13114	23872-23882	NN	denotes	expression
T13115	23883-23885	IN	denotes	in
T13116	23886-23893	NNP	denotes	Sertoli
T13117	23894-23899	NNS	denotes	cells
T13118	23900-23902	IN	denotes	by
T13119	23903-23911	NN	denotes	antibody
T13120	23912-23920	NN	denotes	staining
T13121	23920-23922	,	denotes	,
T13122	23922-23924	PRP	denotes	we
T13123	23925-23937	RB	denotes	nevertheless
T13124	23949-23952	DT	denotes	the
T13125	23953-23964	NN	denotes	possibility
T13126	23965-23969	IN	denotes	that
T13127	23997-24007	VB	denotes	contribute
T13128	23970-23977	NNP	denotes	Sertoli
T13129	23978-23982	NN	denotes	cell
T13130	23983-23990	NNS	denotes	defects
T13131	23991-23996	MD	denotes	might
T13132	24008-24010	IN	denotes	to
T13133	24011-24014	DT	denotes	the
T13134	24039-24046	NN	denotes	failure
T13135	24015-24019	JJ	denotes	male
T13136	24020-24028	JJ	denotes	specific
T13137	24019-24020	HYPH	denotes	-
T13138	24029-24033	NN	denotes	germ
T13139	24034-24038	NN	denotes	line
T13140	24047-24049	IN	denotes	of
T13141	24050-24055	NN	denotes	Dmrt7
T13142	24056-24063	NNS	denotes	mutants
T13143	24063-24064	.	denotes	.
T13144	24064-24256	sentence	denotes	To characterize Sertoli cell differentiation, we examined expression of the Sertoli cell markers GATA4 (a marker of immature postnatal Sertoli cells) and GATA1 (a mature Sertoli cell marker).
T13145	24065-24067	TO	denotes	To
T13146	24068-24080	VB	denotes	characterize
T13147	24114-24122	VBD	denotes	examined
T13148	24081-24088	NNP	denotes	Sertoli
T13149	24089-24093	NN	denotes	cell
T13150	24094-24109	NN	denotes	differentiation
T13151	24109-24111	,	denotes	,
T13152	24111-24113	PRP	denotes	we
T13153	24123-24133	NN	denotes	expression
T13154	24134-24136	IN	denotes	of
T13155	24137-24140	DT	denotes	the
T13156	24154-24161	NNS	denotes	markers
T13157	24141-24148	NNP	denotes	Sertoli
T13158	24149-24153	NN	denotes	cell
T13159	24162-24167	NN	denotes	GATA4
T13160	24168-24169	-LRB-	denotes	(
T13161	24169-24170	DT	denotes	a
T13162	24171-24177	NN	denotes	marker
T13163	24178-24180	IN	denotes	of
T13164	24181-24189	JJ	denotes	immature
T13165	24208-24213	NNS	denotes	cells
T13166	24190-24199	JJ	denotes	postnatal
T13167	24200-24207	NNP	denotes	Sertoli
T13168	24213-24214	-RRB-	denotes	)
T13169	24215-24218	CC	denotes	and
T13170	24219-24224	NN	denotes	GATA1
T13171	24225-24226	-LRB-	denotes	(
T13172	24226-24227	DT	denotes	a
T13173	24248-24254	NN	denotes	marker
T13174	24228-24234	JJ	denotes	mature
T13175	24235-24242	NNP	denotes	Sertoli
T13176	24243-24247	NN	denotes	cell
T13177	24254-24255	-RRB-	denotes	)
T13178	24255-24256	.	denotes	.
T13179	24256-24414	sentence	denotes	The levels of these proteins appeared normal relative to wild-type at P14 and P42 (Figure 6A–6C), as did the androgen receptor (Figure S3; unpublished data).
T13180	24257-24260	DT	denotes	The
T13181	24261-24267	NNS	denotes	levels
T13182	24286-24294	VBD	denotes	appeared
T13183	24268-24270	IN	denotes	of
T13184	24271-24276	DT	denotes	these
T13187	24302-24310	JJ	denotes	relative
T13188	24311-24313	IN	denotes	to
T13189	24314-24318	JJ	denotes	wild
T13190	24319-24323	NN	denotes	type
T13191	24318-24319	HYPH	denotes	-
T13192	24324-24326	IN	denotes	at
T13193	24327-24330	NN	denotes	P14
T13194	24331-24334	CC	denotes	and
T13195	24335-24338	NN	denotes	P42
T13196	24339-24340	-LRB-	denotes	(
T13197	24347-24349	NN	denotes	6A
T13198	24340-24346	NN	denotes	Figure
T13199	24349-24350	SYM	denotes	–
T13200	24350-24352	NN	denotes	6C
T13201	24352-24353	-RRB-	denotes	)
T13202	24353-24355	,	denotes	,
T13203	24355-24357	IN	denotes	as
T13204	24358-24361	VBD	denotes	did
T13205	24362-24365	DT	denotes	the
T13206	24375-24383	NN	denotes	receptor
T13207	24366-24374	NN	denotes	androgen
T13208	24384-24385	-LRB-	denotes	(
T13209	24408-24412	NNS	denotes	data
T13210	24385-24391	NN	denotes	Figure
T13211	24392-24394	NN	denotes	S3
T13212	24394-24395	:	denotes	;
T13213	24396-24407	JJ	denotes	unpublished
T13214	24412-24413	-RRB-	denotes	)
T13215	24413-24414	.	denotes	.
T13216	24414-24634	sentence	denotes	However, the organization of Sertoli cells in Dmrt7 mutant testes was abnormal: in some tubules GATA1-positive Sertoli cell nuclei were displaced from their usual close apposition with the basement membrane (Figure 6C).
T13217	24415-24422	RB	denotes	However
T13218	24481-24484	VBD	denotes	was
T13219	24422-24424	,	denotes	,
T13220	24424-24427	DT	denotes	the
T13221	24428-24440	NN	denotes	organization
T13222	24441-24443	IN	denotes	of
T13223	24444-24451	NNP	denotes	Sertoli
T13224	24452-24457	NNS	denotes	cells
T13225	24458-24460	IN	denotes	in
T13226	24461-24466	NN	denotes	Dmrt7
T13227	24474-24480	NNS	denotes	testes
T13228	24467-24473	NN	denotes	mutant
T13229	24551-24560	VBN	denotes	displaced
T13230	24485-24493	JJ	denotes	abnormal
T13231	24493-24495	:	denotes	:
T13232	24495-24497	IN	denotes	in
T13233	24498-24502	DT	denotes	some
T13234	24503-24510	NNS	denotes	tubules
T13235	24511-24516	NN	denotes	GATA1
T13236	24517-24525	JJ	denotes	positive
T13237	24516-24517	HYPH	denotes	-
T13238	24539-24545	NNS	denotes	nuclei
T13239	24526-24533	NNP	denotes	Sertoli
T13240	24534-24538	NN	denotes	cell
T13241	24546-24550	VBD	denotes	were
T13242	24561-24565	IN	denotes	from
T13243	24566-24571	PRP$	denotes	their
T13244	24584-24594	NN	denotes	apposition
T13245	24572-24577	JJ	denotes	usual
T13246	24578-24583	JJ	denotes	close
T13247	24595-24599	IN	denotes	with
T13248	24600-24603	DT	denotes	the
T13249	24613-24621	NN	denotes	membrane
T13250	24604-24612	NN	denotes	basement
T13251	24622-24623	-LRB-	denotes	(
T13252	24630-24632	NN	denotes	6C
T13253	24623-24629	NN	denotes	Figure
T13254	24632-24633	-RRB-	denotes	)
T13255	24633-24634	.	denotes	.
T13256	24634-24797	sentence	denotes	In such tubules, nuclei of pre-meiotic germ cells and spermatocytes were packed close to the basal membrane and few germ cells were found in the adlumenal region.
T13257	24635-24637	IN	denotes	In
T13258	24708-24714	VBN	denotes	packed
T13259	24638-24642	JJ	denotes	such
T13260	24643-24650	NNS	denotes	tubules
T13261	24650-24652	,	denotes	,
T13262	24652-24658	NNS	denotes	nuclei
T13263	24659-24661	IN	denotes	of
T13264	24662-24673	JJ	denotes	pre-meiotic
T13265	24679-24684	NNS	denotes	cells
T13266	24674-24678	NN	denotes	germ
T13267	24685-24688	CC	denotes	and
T13268	24689-24702	NNS	denotes	spermatocytes
T13269	24703-24707	VBD	denotes	were
T13270	24715-24720	RB	denotes	close
T13271	24721-24723	IN	denotes	to
T13272	24724-24727	DT	denotes	the
T13273	24734-24742	NN	denotes	membrane
T13274	24728-24733	JJ	denotes	basal
T13275	24743-24746	CC	denotes	and
T13276	24747-24750	JJ	denotes	few
T13277	24756-24761	NNS	denotes	cells
T13278	24751-24755	NN	denotes	germ
T13279	24767-24772	VBN	denotes	found
T13280	24762-24766	VBD	denotes	were
T13281	24773-24775	IN	denotes	in
T13282	24776-24779	DT	denotes	the
T13283	24790-24796	NN	denotes	region
T13284	24780-24789	JJ	denotes	adlumenal
T13285	24796-24797	.	denotes	.
T13286	24797-26049	sentence	denotes	Figure 6 Abnormal Sertoli Cell Organization in Dmrt7 Mutant Testes (A) Testes from P14 wild-type and Dmrt7 mutant mice were sectioned and stained with antibody to GATA4. (B) P14 testis sections stained with antibody to GATA1. At P14, GATA4 and GATA1 levels are similar in wild-type and mutant Sertoli cell. (C) Wild-type and mutant testis sections double-stained with antibody to GATA1 (red) and DAPI (blue). Most Sertoli cell nuclei were adjacent to the basal membrane in wild-type, but mutant Sertoli cells were displaced in some tubules (arrowhead). White dotted line indicates position of basal membranes. (D) Testis sections from 10-wk-old wild-type and Sertoli cell-specific Dmrt7 mutant (SC-Dmrt7KO) mice stained with hematoxylin and eosin. Spermatogenesis and spermiogenesis are normal in SC-Dmrt7KO testis. (E) Testis sections from 10-wk-old wild-type and SC-Dmrt7KO mice stained with antibodies to GATA1 (red) and smooth muscle actin (to outline seminiferous tubules; green). Sertoli cell nuclei are positioned normally near the basal membrane in SC-Dmrt7KO mice. The aberrant Sertoli cell organization in Dmrt7 mutant testes raised the possibility that the germ cell phenotype might indirectly result from defects in Sertoli cell function.
T13287	25873-25876	DT	denotes	The
T13288	25899-25911	NN	denotes	organization
T13289	25877-25885	JJ	denotes	aberrant
T13290	25886-25893	NNP	denotes	Sertoli
T13291	25894-25898	NN	denotes	cell
T13292	25935-25941	VBD	denotes	raised
T13293	25912-25914	IN	denotes	in
T13294	25915-25920	NN	denotes	Dmrt7
T13295	25928-25934	NNS	denotes	testes
T13296	25921-25927	NN	denotes	mutant
T13297	25942-25945	DT	denotes	the
T13298	25946-25957	NN	denotes	possibility
T13299	25958-25962	IN	denotes	that
T13300	26004-26010	VB	denotes	result
T13301	25963-25966	DT	denotes	the
T13302	25977-25986	NN	denotes	phenotype
T13303	25967-25971	NN	denotes	germ
T13304	25972-25976	NN	denotes	cell
T13305	25987-25992	MD	denotes	might
T13306	25993-26003	RB	denotes	indirectly
T13307	26011-26015	IN	denotes	from
T13308	26016-26023	NNS	denotes	defects
T13309	26024-26026	IN	denotes	in
T13310	26027-26034	NNP	denotes	Sertoli
T13311	26035-26039	NN	denotes	cell
T13312	26040-26048	NN	denotes	function
T13313	26048-26049	.	denotes	.
T13314	26049-26210	sentence	denotes	To test this possibility, we deleted Dmrt7 just in the Sertoli cell lineage by crossing mice carrying the floxed Dmrt7 allele with Dhh-Cre transgenic mice [51].
T13315	26050-26052	TO	denotes	To
T13316	26053-26057	VB	denotes	test
T13317	26079-26086	VBD	denotes	deleted
T13318	26058-26062	DT	denotes	this
T13319	26063-26074	NN	denotes	possibility
T13320	26074-26076	,	denotes	,
T13321	26076-26078	PRP	denotes	we
T13322	26087-26092	NN	denotes	Dmrt7
T13323	26093-26097	RB	denotes	just
T13324	26098-26100	IN	denotes	in
T13325	26101-26104	DT	denotes	the
T13326	26118-26125	NN	denotes	lineage
T13327	26105-26112	NNP	denotes	Sertoli
T13328	26113-26117	NN	denotes	cell
T13329	26126-26128	IN	denotes	by
T13330	26129-26137	VBG	denotes	crossing
T13331	26138-26142	NNS	denotes	mice
T13332	26143-26151	VBG	denotes	carrying
T13333	26152-26155	DT	denotes	the
T13334	26169-26175	NN	denotes	allele
T13335	26156-26162	VBN	denotes	floxed
T13336	26163-26168	NN	denotes	Dmrt7
T13337	26176-26180	IN	denotes	with
T13338	26181-26184	NN	denotes	Dhh
T13339	26185-26188	NN	denotes	Cre
T13340	26184-26185	HYPH	denotes	-
T13341	26189-26199	JJ	denotes	transgenic
T13342	26200-26204	NNS	denotes	mice
T13343	26205-26206	-LRB-	denotes	[
T13344	26206-26208	CD	denotes	51
T13345	26208-26209	-RRB-	denotes	]
T13346	26209-26210	.	denotes	.
T13347	26210-26425	sentence	denotes	The Desert hedgehog (Dhh) promoter is active starting at about E12.5 in pre-Sertoli cells but not in germ cells, allowing deletion of Dmrt7 in Sertoli cells well before any likely requirement for its function [52].
T13348	26211-26214	DT	denotes	The
T13349	26237-26245	NN	denotes	promoter
T13350	26215-26221	NN	denotes	Desert
T13351	26222-26230	NN	denotes	hedgehog
T13352	26231-26232	-LRB-	denotes	(
T13353	26232-26235	NN	denotes	Dhh
T13354	26235-26236	-RRB-	denotes	)
T13355	26246-26248	VBZ	denotes	is
T13356	26249-26255	JJ	denotes	active
T13357	26256-26264	VBG	denotes	starting
T13358	26265-26267	IN	denotes	at
T13359	26268-26273	IN	denotes	about
T13360	26274-26279	NN	denotes	E12.5
T13361	26280-26282	IN	denotes	in
T13362	26283-26294	JJ	denotes	pre-Sertoli
T13363	26295-26300	NNS	denotes	cells
T13364	26301-26304	CC	denotes	but
T13365	26305-26308	RB	denotes	not
T13366	26309-26311	IN	denotes	in
T13367	26312-26316	NN	denotes	germ
T13368	26317-26322	NNS	denotes	cells
T13369	26322-26324	,	denotes	,
T13370	26324-26332	VBG	denotes	allowing
T13371	26333-26341	NN	denotes	deletion
T13372	26342-26344	IN	denotes	of
T13373	26345-26350	NN	denotes	Dmrt7
T13374	26351-26353	IN	denotes	in
T13375	26354-26361	NNP	denotes	Sertoli
T13376	26362-26367	NNS	denotes	cells
T13377	26368-26372	RB	denotes	well
T13378	26373-26379	IN	denotes	before
T13379	26380-26383	DT	denotes	any
T13380	26391-26402	NN	denotes	requirement
T13381	26384-26390	JJ	denotes	likely
T13382	26403-26406	IN	denotes	for
T13383	26407-26410	PRP$	denotes	its
T13384	26411-26419	NN	denotes	function
T13385	26420-26421	-LRB-	denotes	[
T13386	26421-26423	CD	denotes	52
T13387	26423-26424	-RRB-	denotes	]
T13388	26424-26425	.	denotes	.
T13389	26425-26637	sentence	denotes	Testicular size in Sertoli-targeted (SC-Dmrt7KO) animals was slightly reduced from that of wild-type, but histological analysis revealed no obvious difference between wild-type and SC-Dmrt7KO testes (Figure 6D).
T13390	26426-26436	JJ	denotes	Testicular
T13391	26437-26441	NN	denotes	size
T13392	26496-26503	VBN	denotes	reduced
T13393	26442-26444	IN	denotes	in
T13394	26445-26452	NNP	denotes	Sertoli
T13395	26453-26461	VBN	denotes	targeted
T13396	26452-26453	HYPH	denotes	-
T13397	26475-26482	NNS	denotes	animals
T13398	26462-26463	-LRB-	denotes	(
T13399	26466-26473	NN	denotes	Dmrt7KO
T13400	26463-26465	NN	denotes	SC
T13401	26465-26466	HYPH	denotes	-
T13402	26473-26474	-RRB-	denotes	)
T13403	26483-26486	VBD	denotes	was
T13404	26487-26495	RB	denotes	slightly
T13405	26504-26508	IN	denotes	from
T13406	26509-26513	DT	denotes	that
T13407	26514-26516	IN	denotes	of
T13408	26517-26521	JJ	denotes	wild
T13409	26522-26526	NN	denotes	type
T13410	26521-26522	HYPH	denotes	-
T13411	26526-26528	,	denotes	,
T13412	26528-26531	CC	denotes	but
T13413	26532-26544	JJ	denotes	histological
T13414	26545-26553	NN	denotes	analysis
T13415	26554-26562	VBD	denotes	revealed
T13416	26563-26565	DT	denotes	no
T13417	26574-26584	NN	denotes	difference
T13418	26566-26573	JJ	denotes	obvious
T13419	26585-26592	IN	denotes	between
T13420	26593-26597	JJ	denotes	wild
T13421	26598-26602	NN	denotes	type
T13422	26597-26598	HYPH	denotes	-
T13423	26618-26624	NNS	denotes	testes
T13424	26603-26606	CC	denotes	and
T13425	26607-26609	NN	denotes	SC
T13426	26610-26617	NN	denotes	Dmrt7KO
T13427	26609-26610	HYPH	denotes	-
T13428	26625-26626	-LRB-	denotes	(
T13429	26633-26635	NN	denotes	6D
T13430	26626-26632	NN	denotes	Figure
T13431	26635-26636	-RRB-	denotes	)
T13432	26636-26637	.	denotes	.
T13433	26637-26731	sentence	denotes	Spermatogenesis appeared normal, mature sperm were present, and SC-Dmrt7KO mice were fertile.
T13434	26638-26653	NN	denotes	Spermatogenesis
T13435	26654-26662	VBD	denotes	appeared
T13436	26663-26669	JJ	denotes	normal
T13437	26669-26671	,	denotes	,
T13438	26671-26677	JJ	denotes	mature
T13439	26678-26683	NN	denotes	sperm
T13440	26684-26688	VBD	denotes	were
T13441	26689-26696	JJ	denotes	present
T13442	26696-26698	,	denotes	,
T13443	26698-26701	CC	denotes	and
T13444	26702-26704	NN	denotes	SC
T13445	26705-26712	NN	denotes	Dmrt7KO
T13446	26704-26705	HYPH	denotes	-
T13447	26713-26717	NNS	denotes	mice
T13448	26718-26722	VBD	denotes	were
T13449	26723-26730	JJ	denotes	fertile
T13450	26730-26731	.	denotes	.
T13451	26731-26867	sentence	denotes	In addition, GATA1 staining showed that Sertoli cell nuclei were located adjacent to the basement membrane as in wild-type (Figure 6E).
T13452	26732-26734	IN	denotes	In
T13453	26760-26766	VBD	denotes	showed
T13454	26735-26743	NN	denotes	addition
T13455	26743-26745	,	denotes	,
T13456	26745-26750	NN	denotes	GATA1
T13457	26751-26759	NN	denotes	staining
T13458	26767-26771	IN	denotes	that
T13459	26797-26804	VBN	denotes	located
T13460	26772-26779	NNP	denotes	Sertoli
T13461	26780-26784	NN	denotes	cell
T13462	26785-26791	NNS	denotes	nuclei
T13463	26792-26796	VBD	denotes	were
T13464	26805-26813	JJ	denotes	adjacent
T13465	26814-26816	IN	denotes	to
T13466	26817-26820	DT	denotes	the
T13467	26830-26838	NN	denotes	membrane
T13468	26821-26829	NN	denotes	basement
T13469	26839-26841	IN	denotes	as
T13470	26842-26844	IN	denotes	in
T13471	26845-26849	JJ	denotes	wild
T13472	26850-26854	NN	denotes	type
T13473	26849-26850	HYPH	denotes	-
T13474	26855-26856	-LRB-	denotes	(
T13475	26863-26865	NN	denotes	6E
T13476	26856-26862	NN	denotes	Figure
T13477	26865-26866	-RRB-	denotes	)
T13478	26866-26867	.	denotes	.
T13479	26867-26978	sentence	denotes	These results suggest the germ cell defects of Dmrt7 mutants are not caused by lack of Dmrt7 in Sertoli cells.
T13480	26868-26873	DT	denotes	These
T13481	26874-26881	NNS	denotes	results
T13482	26882-26889	VBP	denotes	suggest
T13483	26890-26893	DT	denotes	the
T13484	26904-26911	NNS	denotes	defects
T13485	26894-26898	NN	denotes	germ
T13486	26899-26903	NN	denotes	cell
T13487	26937-26943	VBN	denotes	caused
T13488	26912-26914	IN	denotes	of
T13489	26915-26920	NN	denotes	Dmrt7
T13490	26921-26928	NNS	denotes	mutants
T13491	26929-26932	VBP	denotes	are
T13492	26933-26936	RB	denotes	not
T13493	26944-26946	IN	denotes	by
T13494	26947-26951	NN	denotes	lack
T13495	26952-26954	IN	denotes	of
T13496	26955-26960	NN	denotes	Dmrt7
T13497	26961-26963	IN	denotes	in
T13498	26964-26971	NNP	denotes	Sertoli
T13499	26972-26977	NNS	denotes	cells
T13500	26977-26978	.	denotes	.
T13501	26978-27084	sentence	denotes	Rather, the abnormal organization of Sertoli cells appears to result from lack of Dmrt7 in the germ line.
T13502	26979-26985	RB	denotes	Rather
T13503	27030-27037	VBZ	denotes	appears
T13504	26985-26987	,	denotes	,
T13505	26987-26990	DT	denotes	the
T13506	27000-27012	NN	denotes	organization
T13507	26991-26999	JJ	denotes	abnormal
T13508	27013-27015	IN	denotes	of
T13509	27016-27023	NNP	denotes	Sertoli
T13510	27024-27029	NNS	denotes	cells
T13511	27038-27040	TO	denotes	to
T13512	27041-27047	VB	denotes	result
T13513	27048-27052	IN	denotes	from
T13514	27053-27057	NN	denotes	lack
T13515	27058-27060	IN	denotes	of
T13516	27061-27066	NN	denotes	Dmrt7
T13517	27067-27069	IN	denotes	in
T13518	27070-27073	DT	denotes	the
T13519	27079-27083	NN	denotes	line
T13520	27074-27078	NN	denotes	germ
T13521	27083-27084	.	denotes	.
T14689	27086-27088	NN	denotes	XY
T14690	27089-27095	NNS	denotes	Bodies
T14691	27096-27100	VBP	denotes	Form
T14692	27101-27109	RB	denotes	Normally
T14693	27110-27112	IN	denotes	in
T14694	27113-27118	NN	denotes	Dmrt7
T14695	27119-27125	NN	denotes	Mutant
T14696	27126-27131	NNS	denotes	Cells
T14697	27131-27324	sentence	denotes	The data presented so far indicate that Dmrt7 mutant germ cells undergo apparently normal early meiosis and then arrest during pachynema due to a strict requirement for Dmrt7 in the germ line.
T14698	27132-27135	DT	denotes	The
T14699	27136-27140	NNS	denotes	data
T14700	27158-27166	VBP	denotes	indicate
T14701	27141-27150	VBN	denotes	presented
T14702	27151-27153	RB	denotes	so
T14703	27154-27157	RB	denotes	far
T14704	27167-27171	IN	denotes	that
T14705	27196-27203	VBP	denotes	undergo
T14706	27172-27177	NN	denotes	Dmrt7
T14707	27190-27195	NNS	denotes	cells
T14708	27178-27184	NN	denotes	mutant
T14709	27185-27189	NN	denotes	germ
T14710	27204-27214	RB	denotes	apparently
T14711	27215-27221	JJ	denotes	normal
T14712	27228-27235	NN	denotes	meiosis
T14713	27222-27227	JJ	denotes	early
T14714	27236-27239	CC	denotes	and
T14715	27240-27244	RB	denotes	then
T14716	27245-27251	VBP	denotes	arrest
T14717	27252-27258	IN	denotes	during
T14718	27259-27268	NN	denotes	pachynema
T14719	27269-27272	IN	denotes	due
T14720	27273-27275	IN	denotes	to
T14721	27276-27277	DT	denotes	a
T14722	27285-27296	NN	denotes	requirement
T14723	27278-27284	JJ	denotes	strict
T14724	27297-27300	IN	denotes	for
T14725	27301-27306	NN	denotes	Dmrt7
T14726	27307-27309	IN	denotes	in
T14727	27310-27313	DT	denotes	the
T14728	27319-27323	NN	denotes	line
T14729	27314-27318	NN	denotes	germ
T14730	27323-27324	.	denotes	.
T14731	27324-27437	sentence	denotes	To better understand the basis of the meiotic arrest, we more closely examined meiotic germ cells in the mutant.
T14732	27325-27327	TO	denotes	To
T14733	27335-27345	VB	denotes	understand
T14734	27328-27334	RBR	denotes	better
T14735	27395-27403	VBN	denotes	examined
T14736	27346-27349	DT	denotes	the
T14737	27350-27355	NN	denotes	basis
T14738	27356-27358	IN	denotes	of
T14739	27359-27362	DT	denotes	the
T14740	27371-27377	NN	denotes	arrest
T14741	27363-27370	JJ	denotes	meiotic
T14742	27377-27379	,	denotes	,
T14743	27379-27381	PRP	denotes	we
T14744	27382-27386	RBR	denotes	more
T14745	27387-27394	RB	denotes	closely
T14746	27404-27411	JJ	denotes	meiotic
T14747	27417-27422	NNS	denotes	cells
T14748	27412-27416	NN	denotes	germ
T14749	27423-27425	IN	denotes	in
T14750	27426-27429	DT	denotes	the
T14751	27430-27436	NN	denotes	mutant
T14752	27436-27437	.	denotes	.
T14753	27437-27573	sentence	denotes	We focused on the XY body, which is thought to be essential for meiotic progression and is the site of preferential DMRT7 localization.
T14754	27438-27440	PRP	denotes	We
T14755	27441-27448	VBD	denotes	focused
T14756	27449-27451	IN	denotes	on
T14757	27452-27455	DT	denotes	the
T14758	27459-27463	NN	denotes	body
T14759	27456-27458	NN	denotes	XY
T14760	27463-27465	,	denotes	,
T14761	27465-27470	WDT	denotes	which
T14762	27474-27481	VBN	denotes	thought
T14763	27471-27473	VBZ	denotes	is
T14764	27482-27484	TO	denotes	to
T14765	27485-27487	VB	denotes	be
T14766	27488-27497	JJ	denotes	essential
T14767	27498-27501	IN	denotes	for
T14768	27502-27509	JJ	denotes	meiotic
T14769	27510-27521	NN	denotes	progression
T14770	27522-27525	CC	denotes	and
T14771	27526-27528	VBZ	denotes	is
T14772	27529-27532	DT	denotes	the
T14773	27533-27537	NN	denotes	site
T14774	27538-27540	IN	denotes	of
T14775	27541-27553	JJ	denotes	preferential
T14776	27560-27572	NN	denotes	localization
T14777	27554-27559	NN	denotes	DMRT7
T14778	27572-27573	.	denotes	.
T14779	27573-27822	sentence	denotes	Condensation of the X and Y chromosomes begins in late-zygotene cells, and, by mid-pachynema (when homologous chromosome pairs are fully aligned) the sex chromatin forms a microscopically visible spherical structure near the nuclear periphery [53].
T14780	27574-27586	NN	denotes	Condensation
T14781	27614-27620	VBZ	denotes	begins
T14782	27587-27589	IN	denotes	of
T14783	27590-27593	DT	denotes	the
T14784	27602-27613	NNS	denotes	chromosomes
T14785	27594-27595	NN	denotes	X
T14786	27596-27599	CC	denotes	and
T14787	27600-27601	NN	denotes	Y
T14788	27621-27623	IN	denotes	in
T14789	27624-27628	JJ	denotes	late
T14790	27629-27637	NN	denotes	zygotene
T14791	27628-27629	HYPH	denotes	-
T14792	27638-27643	NNS	denotes	cells
T14793	27643-27645	,	denotes	,
T14794	27645-27648	CC	denotes	and
T14795	27648-27650	,	denotes	,
T14796	27650-27652	IN	denotes	by
T14797	27738-27743	VBZ	denotes	forms
T14798	27653-27666	NN	denotes	mid-pachynema
T14799	27667-27668	-LRB-	denotes	(
T14800	27711-27718	VBN	denotes	aligned
T14801	27668-27672	WRB	denotes	when
T14802	27673-27683	JJ	denotes	homologous
T14803	27695-27700	NNS	denotes	pairs
T14804	27684-27694	NN	denotes	chromosome
T14805	27701-27704	VBP	denotes	are
T14806	27705-27710	RB	denotes	fully
T14807	27718-27719	-RRB-	denotes	)
T14808	27720-27723	DT	denotes	the
T14809	27728-27737	NN	denotes	chromatin
T14810	27724-27727	NN	denotes	sex
T14811	27744-27745	DT	denotes	a
T14812	27780-27789	NN	denotes	structure
T14813	27746-27761	RB	denotes	microscopically
T14814	27762-27769	JJ	denotes	visible
T14815	27770-27779	JJ	denotes	spherical
T14816	27790-27794	IN	denotes	near
T14817	27795-27798	DT	denotes	the
T14818	27807-27816	NN	denotes	periphery
T14819	27799-27806	JJ	denotes	nuclear
T14820	27817-27818	-LRB-	denotes	[
T14821	27818-27820	CD	denotes	53
T14822	27820-27821	-RRB-	denotes	]
T14823	27821-27822	.	denotes	.
T14824	27822-27950	sentence	denotes	We first asked whether DMRT7 is required for XY body formation by evaluating several characteristic XY body chromatin features.
T14825	27823-27825	PRP	denotes	We
T14826	27832-27837	VBD	denotes	asked
T14827	27826-27831	RB	denotes	first
T14828	27838-27845	IN	denotes	whether
T14829	27855-27863	VBN	denotes	required
T14830	27846-27851	NN	denotes	DMRT7
T14831	27852-27854	VBZ	denotes	is
T14832	27864-27867	IN	denotes	for
T14833	27868-27870	NN	denotes	XY
T14834	27871-27875	NN	denotes	body
T14835	27876-27885	NN	denotes	formation
T14836	27886-27888	IN	denotes	by
T14837	27889-27899	VBG	denotes	evaluating
T14838	27900-27907	JJ	denotes	several
T14839	27941-27949	NNS	denotes	features
T14840	27908-27922	JJ	denotes	characteristic
T14841	27923-27925	NN	denotes	XY
T14842	27926-27930	NN	denotes	body
T14843	27931-27940	NN	denotes	chromatin
T14844	27949-27950	.	denotes	.
T14845	27950-28015	sentence	denotes	First, we tested γH2AX expression by immunofluorescent staining.
T14846	27951-27956	RB	denotes	First
T14847	27961-27967	VBD	denotes	tested
T14848	27956-27958	,	denotes	,
T14849	27958-27960	PRP	denotes	we
T14850	27968-27973	NN	denotes	γH2AX
T14851	27974-27984	NN	denotes	expression
T14852	27985-27987	IN	denotes	by
T14853	27988-28005	JJ	denotes	immunofluorescent
T14854	28006-28014	NN	denotes	staining
T14855	28014-28015	.	denotes	.
T14856	28015-28093	sentence	denotes	H2AX is a variant of H2A that is crucial for XY body formation and MSCI [12].
T14857	28016-28020	NN	denotes	H2AX
T14858	28021-28023	VBZ	denotes	is
T14859	28024-28025	DT	denotes	a
T14860	28026-28033	NN	denotes	variant
T14861	28034-28036	IN	denotes	of
T14862	28037-28040	NN	denotes	H2A
T14863	28041-28045	WDT	denotes	that
T14864	28046-28048	VBZ	denotes	is
T14865	28049-28056	JJ	denotes	crucial
T14866	28057-28060	IN	denotes	for
T14867	28061-28063	NN	denotes	XY
T14868	28064-28068	NN	denotes	body
T14869	28069-28078	NN	denotes	formation
T14870	28079-28082	CC	denotes	and
T14871	28083-28087	NN	denotes	MSCI
T14872	28088-28089	-LRB-	denotes	[
T14873	28089-28091	CD	denotes	12
T14874	28091-28092	-RRB-	denotes	]
T14875	28092-28093	.	denotes	.
T14876	28093-28281	sentence	denotes	γH2AX localized normally to the XY body of DMRT7 mutant cells in meiotic spreads (Figure 7A), and many γH2AX-positive puncta were present in germ cells of Dmrt7 mutant testes (Figure 7B).
T14877	28094-28099	NN	denotes	γH2AX
T14878	28100-28109	VBD	denotes	localized
T14879	28110-28118	RB	denotes	normally
T14880	28119-28121	IN	denotes	to
T14881	28122-28125	DT	denotes	the
T14882	28129-28133	NN	denotes	body
T14883	28126-28128	NN	denotes	XY
T14884	28134-28136	IN	denotes	of
T14885	28137-28142	NN	denotes	DMRT7
T14886	28150-28155	NNS	denotes	cells
T14887	28143-28149	NN	denotes	mutant
T14888	28156-28158	IN	denotes	in
T14889	28159-28166	JJ	denotes	meiotic
T14890	28167-28174	NNS	denotes	spreads
T14891	28175-28176	-LRB-	denotes	(
T14892	28183-28185	NN	denotes	7A
T14893	28176-28182	NN	denotes	Figure
T14894	28185-28186	-RRB-	denotes	)
T14895	28186-28188	,	denotes	,
T14896	28188-28191	CC	denotes	and
T14897	28192-28196	JJ	denotes	many
T14898	28212-28218	NNS	denotes	puncta
T14899	28197-28202	NN	denotes	γH2AX
T14900	28203-28211	JJ	denotes	positive
T14901	28202-28203	HYPH	denotes	-
T14902	28219-28223	VBD	denotes	were
T14903	28224-28231	JJ	denotes	present
T14904	28232-28234	IN	denotes	in
T14905	28235-28239	NN	denotes	germ
T14906	28240-28245	NNS	denotes	cells
T14907	28246-28248	IN	denotes	of
T14908	28249-28254	NN	denotes	Dmrt7
T14909	28255-28261	NN	denotes	mutant
T14910	28262-28268	NNS	denotes	testes
T14911	28269-28270	-LRB-	denotes	(
T14912	28277-28279	NN	denotes	7B
T14913	28270-28276	NN	denotes	Figure
T14914	28279-28280	-RRB-	denotes	)
T14915	28280-28281	.	denotes	.
T14916	28281-28341	sentence	denotes	Next, we examined SUMO-1 localization in the mutant testis.
T14917	28282-28286	RB	denotes	Next
T14918	28291-28299	VBD	denotes	examined
T14919	28286-28288	,	denotes	,
T14920	28288-28290	PRP	denotes	we
T14921	28300-28304	NN	denotes	SUMO
T14922	28307-28319	NN	denotes	localization
T14923	28304-28305	HYPH	denotes	-
T14924	28305-28306	CD	denotes	1
T14925	28320-28322	IN	denotes	in
T14926	28323-28326	DT	denotes	the
T14927	28334-28340	NN	denotes	testis
T14928	28327-28333	NN	denotes	mutant
T14929	28340-28341	.	denotes	.
T14930	28341-28478	sentence	denotes	SUMO-1 expression normally increases in the XY body of early- to mid-pachytene spermatocytes at the time of sex chromosome condensation.
T14931	28342-28346	NN	denotes	SUMO
T14932	28349-28359	NN	denotes	expression
T14933	28346-28347	HYPH	denotes	-
T14934	28347-28348	CD	denotes	1
T14935	28369-28378	VBZ	denotes	increases
T14936	28360-28368	RB	denotes	normally
T14937	28379-28381	IN	denotes	in
T14938	28382-28385	DT	denotes	the
T14939	28389-28393	NN	denotes	body
T14940	28386-28388	NN	denotes	XY
T14941	28394-28396	IN	denotes	of
T14942	28397-28402	JJ	denotes	early
T14943	28421-28434	NNS	denotes	spermatocytes
T14944	28402-28403	HYPH	denotes	-
T14945	28404-28406	IN	denotes	to
T14946	28407-28420	NN	denotes	mid-pachytene
T14947	28435-28437	IN	denotes	at
T14948	28438-28441	DT	denotes	the
T14949	28442-28446	NN	denotes	time
T14950	28447-28449	IN	denotes	of
T14951	28450-28453	NN	denotes	sex
T14952	28454-28464	NN	denotes	chromosome
T14953	28465-28477	NN	denotes	condensation
T14954	28477-28478	.	denotes	.
T14955	28478-28611	sentence	denotes	Prior to the completion of the first meiotic division, SUMO-1 disappears from the XY body as the X and Y chromosomes desynapse [40].
T14956	28479-28484	IN	denotes	Prior
T14957	28541-28551	VBZ	denotes	disappears
T14958	28485-28487	IN	denotes	to
T14959	28488-28491	DT	denotes	the
T14960	28492-28502	NN	denotes	completion
T14961	28503-28505	IN	denotes	of
T14962	28506-28509	DT	denotes	the
T14963	28524-28532	NN	denotes	division
T14964	28510-28515	JJ	denotes	first
T14965	28516-28523	JJ	denotes	meiotic
T14966	28532-28534	,	denotes	,
T14967	28534-28538	NN	denotes	SUMO
T14968	28538-28539	HYPH	denotes	-
T14969	28539-28540	CD	denotes	1
T14970	28552-28556	IN	denotes	from
T14971	28557-28560	DT	denotes	the
T14972	28564-28568	NN	denotes	body
T14973	28561-28563	NN	denotes	XY
T14974	28569-28571	IN	denotes	as
T14975	28596-28605	VBP	denotes	desynapse
T14976	28572-28575	DT	denotes	the
T14977	28584-28595	NNS	denotes	chromosomes
T14978	28576-28577	NN	denotes	X
T14979	28578-28581	CC	denotes	and
T14980	28582-28583	NN	denotes	Y
T14981	28606-28607	-LRB-	denotes	[
T14982	28607-28609	CD	denotes	40
T14983	28609-28610	-RRB-	denotes	]
T14984	28610-28611	.	denotes	.
T14985	28611-28755	sentence	denotes	Punctate SUMO-1 localization was present in Dmrt7 mutant germ cells, again consistent with formation of a correctly marked XY body (Figure 7C).
T14986	28612-28620	JJ	denotes	Punctate
T14987	28628-28640	NN	denotes	localization
T14988	28621-28625	NN	denotes	SUMO
T14989	28625-28626	HYPH	denotes	-
T14990	28626-28627	CD	denotes	1
T14991	28641-28644	VBD	denotes	was
T14992	28645-28652	JJ	denotes	present
T14993	28653-28655	IN	denotes	in
T14994	28656-28661	NN	denotes	Dmrt7
T14995	28674-28679	NNS	denotes	cells
T14996	28662-28668	NN	denotes	mutant
T14997	28669-28673	NN	denotes	germ
T14998	28679-28681	,	denotes	,
T14999	28681-28686	RB	denotes	again
T15000	28687-28697	JJ	denotes	consistent
T15001	28698-28702	IN	denotes	with
T15002	28703-28712	NN	denotes	formation
T15003	28713-28715	IN	denotes	of
T15004	28716-28717	DT	denotes	a
T15005	28738-28742	NN	denotes	body
T15006	28718-28727	RB	denotes	correctly
T15007	28728-28734	JJ	denotes	marked
T15008	28735-28737	NN	denotes	XY
T15009	28743-28744	-LRB-	denotes	(
T15010	28751-28753	NN	denotes	7C
T15011	28744-28750	NN	denotes	Figure
T15012	28753-28754	-RRB-	denotes	)
T15013	28754-28755	.	denotes	.
T15014	28755-28904	sentence	denotes	However, some tubules in mutants had multiple layers of cells with SUMO-1-condensed spots (Figure 7C), rather than the normal single layer of cells.
T15015	28756-28763	RB	denotes	However
T15016	28789-28792	VBD	denotes	had
T15017	28763-28765	,	denotes	,
T15018	28765-28769	DT	denotes	some
T15019	28770-28777	NNS	denotes	tubules
T15020	28778-28780	IN	denotes	in
T15021	28781-28788	NNS	denotes	mutants
T15022	28793-28801	JJ	denotes	multiple
T15023	28802-28808	NNS	denotes	layers
T15024	28809-28811	IN	denotes	of
T15025	28812-28817	NNS	denotes	cells
T15026	28818-28822	IN	denotes	with
T15027	28823-28827	NN	denotes	SUMO
T15028	28830-28839	VBN	denotes	condensed
T15029	28827-28828	HYPH	denotes	-
T15030	28828-28829	CD	denotes	1
T15031	28829-28830	HYPH	denotes	-
T15032	28840-28845	NNS	denotes	spots
T15033	28846-28847	-LRB-	denotes	(
T15034	28854-28856	NN	denotes	7C
T15035	28847-28853	NN	denotes	Figure
T15036	28856-28857	-RRB-	denotes	)
T15037	28857-28859	,	denotes	,
T15038	28859-28865	RB	denotes	rather
T15039	28866-28870	IN	denotes	than
T15040	28871-28874	DT	denotes	the
T15041	28889-28894	NN	denotes	layer
T15042	28875-28881	JJ	denotes	normal
T15043	28882-28888	JJ	denotes	single
T15044	28895-28897	IN	denotes	of
T15045	28898-28903	NNS	denotes	cells
T15046	28903-28904	.	denotes	.
T15047	28904-29077	sentence	denotes	This accumulation of XY body–containing cells also was apparent with γH2AX staining and is consistent with a developmental arrest of mutant cells in mid- to late-pachytene.
T15048	28905-28909	DT	denotes	This
T15049	28910-28922	NN	denotes	accumulation
T15050	28956-28959	VBD	denotes	was
T15051	28923-28925	IN	denotes	of
T15052	28926-28928	NN	denotes	XY
T15053	28929-28933	NN	denotes	body
T15054	28934-28944	VBG	denotes	containing
T15055	28933-28934	HYPH	denotes	–
T15056	28945-28950	NNS	denotes	cells
T15057	28951-28955	RB	denotes	also
T15058	28960-28968	JJ	denotes	apparent
T15059	28969-28973	IN	denotes	with
T15060	28974-28979	NN	denotes	γH2AX
T15061	28980-28988	NN	denotes	staining
T15062	28989-28992	CC	denotes	and
T15063	28993-28995	VBZ	denotes	is
T15064	28996-29006	JJ	denotes	consistent
T15065	29007-29011	IN	denotes	with
T15066	29012-29013	DT	denotes	a
T15067	29028-29034	NN	denotes	arrest
T15068	29014-29027	JJ	denotes	developmental
T15069	29035-29037	IN	denotes	of
T15070	29038-29044	NN	denotes	mutant
T15071	29045-29050	NNS	denotes	cells
T15072	29051-29053	IN	denotes	in
T15073	29054-29057	JJ	denotes	mid
T15074	29067-29076	NN	denotes	pachytene
T15075	29057-29058	HYPH	denotes	-
T15076	29059-29061	IN	denotes	to
T15077	29062-29066	JJ	denotes	late
T15078	29066-29067	HYPH	denotes	-
T15079	29076-29077	.	denotes	.
T15080	29077-29138	sentence	denotes	We also examined Ub-H2A localization in Dmrt7 mutant testes.
T15081	29078-29080	PRP	denotes	We
T15082	29086-29094	VBD	denotes	examined
T15083	29081-29085	RB	denotes	also
T15084	29095-29097	NN	denotes	Ub
T15085	29098-29101	NN	denotes	H2A
T15086	29097-29098	HYPH	denotes	-
T15087	29102-29114	NN	denotes	localization
T15088	29115-29117	IN	denotes	in
T15089	29118-29123	NN	denotes	Dmrt7
T15090	29124-29130	NN	denotes	mutant
T15091	29131-29137	NNS	denotes	testes
T15092	29137-29138	.	denotes	.
T15093	29138-29346	sentence	denotes	In early-pachytene, Ub-H2A is concentrated in the XY body; by mid-pachytene Ub-H2A is observed throughout the entire nucleus, but it again becomes limited to the XY body in late-pachytene spermatocytes [13].
T15094	29139-29141	IN	denotes	In
T15095	29169-29181	VBN	denotes	concentrated
T15096	29142-29147	JJ	denotes	early
T15097	29148-29157	NN	denotes	pachytene
T15098	29147-29148	HYPH	denotes	-
T15099	29157-29159	,	denotes	,
T15100	29159-29161	NN	denotes	Ub
T15101	29162-29165	NN	denotes	H2A
T15102	29161-29162	HYPH	denotes	-
T15103	29166-29168	VBZ	denotes	is
T15104	29225-29233	VBN	denotes	observed
T15105	29182-29184	IN	denotes	in
T15106	29185-29188	DT	denotes	the
T15107	29192-29196	NN	denotes	body
T15108	29189-29191	NN	denotes	XY
T15109	29196-29197	:	denotes	;
T15110	29198-29200	IN	denotes	by
T15111	29201-29214	NN	denotes	mid-pachytene
T15112	29215-29217	NN	denotes	Ub
T15113	29218-29221	NN	denotes	H2A
T15114	29217-29218	HYPH	denotes	-
T15115	29222-29224	VBZ	denotes	is
T15116	29234-29244	IN	denotes	throughout
T15117	29245-29248	DT	denotes	the
T15118	29256-29263	NN	denotes	nucleus
T15119	29249-29255	JJ	denotes	entire
T15120	29263-29265	,	denotes	,
T15121	29265-29268	CC	denotes	but
T15122	29269-29271	PRP	denotes	it
T15123	29278-29285	VBZ	denotes	becomes
T15124	29272-29277	RB	denotes	again
T15125	29286-29293	JJ	denotes	limited
T15126	29294-29296	IN	denotes	to
T15127	29297-29300	DT	denotes	the
T15128	29304-29308	NN	denotes	body
T15129	29301-29303	NN	denotes	XY
T15130	29309-29311	IN	denotes	in
T15131	29312-29316	JJ	denotes	late
T15132	29317-29326	NN	denotes	pachytene
T15133	29316-29317	HYPH	denotes	-
T15134	29327-29340	NNS	denotes	spermatocytes
T15135	29341-29342	-LRB-	denotes	[
T15136	29342-29344	CD	denotes	13
T15137	29344-29345	-RRB-	denotes	]
T15138	29345-29346	.	denotes	.
T15139	29346-29459	sentence	denotes	Analysis of nuclear spreads revealed that Ub-H2A localizes normally to the XY body in Dmrt7 mutants (Figure S4).
T15140	29347-29355	NN	denotes	Analysis
T15141	29375-29383	VBD	denotes	revealed
T15142	29356-29358	IN	denotes	of
T15143	29359-29366	JJ	denotes	nuclear
T15144	29367-29374	NNS	denotes	spreads
T15145	29384-29388	IN	denotes	that
T15146	29396-29405	VBZ	denotes	localizes
T15147	29389-29391	NN	denotes	Ub
T15148	29392-29395	NN	denotes	H2A
T15149	29391-29392	HYPH	denotes	-
T15150	29406-29414	RB	denotes	normally
T15151	29415-29417	IN	denotes	to
T15152	29418-29421	DT	denotes	the
T15153	29425-29429	NN	denotes	body
T15154	29422-29424	NN	denotes	XY
T15155	29430-29432	IN	denotes	in
T15156	29433-29438	NN	denotes	Dmrt7
T15157	29439-29446	NNS	denotes	mutants
T15158	29447-29448	-LRB-	denotes	(
T15159	29455-29457	NN	denotes	S4
T15160	29448-29454	NN	denotes	Figure
T15161	29457-29458	-RRB-	denotes	)
T15162	29458-29459	.	denotes	.
T15163	29459-29600	sentence	denotes	Collectively, these results indicate that Dmrt7 mutant germ cells can establish an XY body with at least some of the normal chromatin marks.
T15164	29460-29472	RB	denotes	Collectively
T15165	29488-29496	VBP	denotes	indicate
T15166	29472-29474	,	denotes	,
T15167	29474-29479	DT	denotes	these
T15168	29480-29487	NNS	denotes	results
T15169	29497-29501	IN	denotes	that
T15170	29530-29539	VB	denotes	establish
T15171	29502-29507	NN	denotes	Dmrt7
T15172	29520-29525	NNS	denotes	cells
T15173	29508-29514	NN	denotes	mutant
T15174	29515-29519	NN	denotes	germ
T15175	29526-29529	MD	denotes	can
T15176	29540-29542	DT	denotes	an
T15177	29546-29550	NN	denotes	body
T15178	29543-29545	NN	denotes	XY
T15179	29551-29555	IN	denotes	with
T15180	29556-29558	RB	denotes	at
T15181	29559-29564	RBS	denotes	least
T15182	29565-29569	DT	denotes	some
T15183	29570-29572	IN	denotes	of
T15184	29573-29576	DT	denotes	the
T15185	29594-29599	NNS	denotes	marks
T15186	29577-29583	JJ	denotes	normal
T15187	29584-29593	NN	denotes	chromatin
T15188	29599-29600	.	denotes	.
T21793	38160-38162	IN	denotes	in
T21794	38163-38168	NN	denotes	Dmrt7
T17284	30107-30115	JJ	denotes	Abnormal
T17285	30120-30129	NN	denotes	Chromatin
T17286	30116-30119	NN	denotes	Sex
T17287	30130-30132	IN	denotes	in
T17288	30133-30138	NN	denotes	Dmrt7
T17289	30139-30145	NN	denotes	Mutant
T17290	30151-30156	NNS	denotes	Cells
T17291	30146-30150	NN	denotes	Germ
T17292	30156-30317	sentence	denotes	Although the XY body can form during pachynema in Dmrt7 mutants, we considered the possibility that transcriptional silencing might not be properly established.
T17293	30157-30165	IN	denotes	Although
T17294	30182-30186	VB	denotes	form
T17295	30166-30169	DT	denotes	the
T17296	30173-30177	NN	denotes	body
T17297	30170-30172	NN	denotes	XY
T17298	30178-30181	MD	denotes	can
T17299	30225-30235	VBD	denotes	considered
T17300	30187-30193	IN	denotes	during
T17301	30194-30203	NN	denotes	pachynema
T17302	30204-30206	IN	denotes	in
T17303	30207-30212	NN	denotes	Dmrt7
T17304	30213-30220	NNS	denotes	mutants
T17305	30220-30222	,	denotes	,
T17306	30222-30224	PRP	denotes	we
T17307	30236-30239	DT	denotes	the
T17308	30240-30251	NN	denotes	possibility
T17309	30252-30256	IN	denotes	that
T17310	30305-30316	VBN	denotes	established
T17311	30257-30272	JJ	denotes	transcriptional
T17312	30273-30282	NN	denotes	silencing
T17313	30283-30288	MD	denotes	might
T17314	30289-30292	RB	denotes	not
T17315	30293-30295	VB	denotes	be
T17316	30296-30304	RB	denotes	properly
T17317	30316-30317	.	denotes	.
T17318	30317-30460	sentence	denotes	This would be consistent with the Dmrt7 phenotype: pachytene cells that escape from MSCI normally are eliminated prior to late-pachytene [17].
T17319	30318-30322	DT	denotes	This
T17320	30329-30331	VB	denotes	be
T17321	30323-30328	MD	denotes	would
T17322	30420-30430	VBN	denotes	eliminated
T17323	30332-30342	JJ	denotes	consistent
T17324	30343-30347	IN	denotes	with
T17325	30348-30351	DT	denotes	the
T17326	30358-30367	NN	denotes	phenotype
T17327	30352-30357	NN	denotes	Dmrt7
T17328	30367-30369	:	denotes	:
T17329	30369-30378	NN	denotes	pachytene
T17330	30379-30384	NNS	denotes	cells
T17331	30385-30389	WDT	denotes	that
T17332	30390-30396	VBP	denotes	escape
T17333	30397-30401	IN	denotes	from
T17334	30402-30406	NN	denotes	MSCI
T17335	30407-30415	RB	denotes	normally
T17336	30416-30419	VBP	denotes	are
T17337	30431-30436	IN	denotes	prior
T17338	30437-30439	IN	denotes	to
T17339	30440-30444	JJ	denotes	late
T17340	30445-30454	NN	denotes	pachytene
T17341	30444-30445	HYPH	denotes	-
T17342	30455-30456	-LRB-	denotes	[
T17343	30456-30458	CD	denotes	17
T17344	30458-30459	-RRB-	denotes	]
T17345	30459-30460	.	denotes	.
T17346	30460-30682	sentence	denotes	Recently, MSCI has been shown to continue into meiosis II and spermiogenesis, apparently mediated by a distinct chromatin compartment termed postmeiotic sex chromatin (PMSC) that is established starting in diplonema [16].
T17347	30461-30469	RB	denotes	Recently
T17348	30485-30490	VBN	denotes	shown
T17349	30469-30471	,	denotes	,
T17350	30471-30475	NN	denotes	MSCI
T17351	30476-30479	VBZ	denotes	has
T17352	30480-30484	VBN	denotes	been
T17353	30491-30493	TO	denotes	to
T17354	30494-30502	VB	denotes	continue
T17355	30503-30507	IN	denotes	into
T17356	30508-30515	NN	denotes	meiosis
T17357	30516-30518	CD	denotes	II
T17358	30519-30522	CC	denotes	and
T17359	30523-30537	NN	denotes	spermiogenesis
T17360	30537-30539	,	denotes	,
T17361	30539-30549	RB	denotes	apparently
T17362	30550-30558	VBN	denotes	mediated
T17363	30559-30561	IN	denotes	by
T17364	30562-30563	DT	denotes	a
T17365	30583-30594	NN	denotes	compartment
T17366	30564-30572	JJ	denotes	distinct
T17367	30573-30582	NN	denotes	chromatin
T17368	30595-30601	VBN	denotes	termed
T17369	30602-30613	JJ	denotes	postmeiotic
T17370	30618-30627	NN	denotes	chromatin
T17371	30614-30617	NN	denotes	sex
T17372	30628-30629	-LRB-	denotes	(
T17373	30629-30633	NN	denotes	PMSC
T17374	30633-30634	-RRB-	denotes	)
T17375	30635-30639	WDT	denotes	that
T17376	30643-30654	VBN	denotes	established
T17377	30640-30642	VBZ	denotes	is
T17378	30655-30663	VBG	denotes	starting
T17379	30664-30666	IN	denotes	in
T17380	30667-30676	NN	denotes	diplonema
T17381	30677-30678	-LRB-	denotes	[
T17382	30678-30680	CD	denotes	16
T17383	30680-30681	-RRB-	denotes	]
T17384	30681-30682	.	denotes	.
T17385	30682-30848	sentence	denotes	We therefore asked whether the pachytene germ cell death in Dmrt7 mutants is associated with a failure either to initiate or to maintain sex chromosome inactivation.
T17386	30683-30685	PRP	denotes	We
T17387	30696-30701	VBD	denotes	asked
T17388	30686-30695	RB	denotes	therefore
T17389	30702-30709	IN	denotes	whether
T17390	30760-30770	VBN	denotes	associated
T17391	30710-30713	DT	denotes	the
T17392	30734-30739	NN	denotes	death
T17393	30714-30723	NN	denotes	pachytene
T17394	30724-30728	NN	denotes	germ
T17395	30729-30733	NN	denotes	cell
T17396	30740-30742	IN	denotes	in
T17397	30743-30748	NN	denotes	Dmrt7
T17398	30749-30756	NNS	denotes	mutants
T17399	30757-30759	VBZ	denotes	is
T17400	30771-30775	IN	denotes	with
T17401	30776-30777	DT	denotes	a
T17402	30778-30785	NN	denotes	failure
T17403	30786-30792	CC	denotes	either
T17404	30796-30804	VB	denotes	initiate
T17405	30793-30795	TO	denotes	to
T17406	30805-30807	CC	denotes	or
T17407	30808-30810	TO	denotes	to
T17408	30811-30819	VB	denotes	maintain
T17409	30820-30823	NN	denotes	sex
T17410	30824-30834	NN	denotes	chromosome
T17411	30835-30847	NN	denotes	inactivation
T17412	30847-30848	.	denotes	.
T17413	30848-30894	sentence	denotes	First, we examined the mid-pachytene XY body.
T17414	30849-30854	RB	denotes	First
T17415	30859-30867	VBD	denotes	examined
T17416	30854-30856	,	denotes	,
T17417	30856-30858	PRP	denotes	we
T17418	30868-30871	DT	denotes	the
T17419	30889-30893	NN	denotes	body
T17420	30872-30885	JJ	denotes	mid-pachytene
T17421	30886-30888	NN	denotes	XY
T17422	30893-30894	.	denotes	.
T17423	30894-31155	sentence	denotes	To examine XY transcriptional status, we carried out Cot-1 RNA fluorescence in situ hybridization (FISH) to detect nascent RNA polymerase II transcription, combined with DAPI staining to locate the XY body on spreads of seminiferous tubules (Figure 8A and 8B).
T17424	30895-30897	TO	denotes	To
T17425	30898-30905	VB	denotes	examine
T17426	30936-30943	VBD	denotes	carried
T17427	30906-30908	NN	denotes	XY
T17428	30925-30931	NN	denotes	status
T17429	30909-30924	JJ	denotes	transcriptional
T17430	30931-30933	,	denotes	,
T17431	30933-30935	PRP	denotes	we
T17432	30944-30947	RP	denotes	out
T17433	30948-30951	NN	denotes	Cot
T17434	30979-30992	NN	denotes	hybridization
T17435	30951-30952	HYPH	denotes	-
T17436	30952-30953	CD	denotes	1
T17437	30954-30957	NN	denotes	RNA
T17438	30958-30970	NN	denotes	fluorescence
T17439	30971-30973	FW	denotes	in
T17440	30974-30978	FW	denotes	situ
T17441	30993-30994	-LRB-	denotes	(
T17442	30994-30998	NN	denotes	FISH
T17443	30998-30999	-RRB-	denotes	)
T17444	31000-31002	TO	denotes	to
T17445	31003-31009	VB	denotes	detect
T17446	31010-31017	JJ	denotes	nascent
T17447	31036-31049	NN	denotes	transcription
T17448	31018-31021	NN	denotes	RNA
T17449	31022-31032	NN	denotes	polymerase
T17450	31033-31035	CD	denotes	II
T17451	31049-31051	,	denotes	,
T17452	31051-31059	VBN	denotes	combined
T17453	31060-31064	IN	denotes	with
T17454	31065-31069	NN	denotes	DAPI
T17455	31070-31078	NN	denotes	staining
T17456	31079-31081	TO	denotes	to
T17457	31082-31088	VB	denotes	locate
T17458	31089-31092	DT	denotes	the
T17459	31096-31100	NN	denotes	body
T17460	31093-31095	NN	denotes	XY
T17461	31101-31103	IN	denotes	on
T17462	31104-31111	NNS	denotes	spreads
T17463	31112-31114	IN	denotes	of
T17464	31115-31127	JJ	denotes	seminiferous
T17465	31128-31135	NNS	denotes	tubules
T17466	31136-31137	-LRB-	denotes	(
T17467	31144-31146	NN	denotes	8A
T17468	31137-31143	NN	denotes	Figure
T17469	31147-31150	CC	denotes	and
T17470	31151-31153	NN	denotes	8B
T17471	31153-31154	-RRB-	denotes	)
T17472	31154-31155	.	denotes	.
T17473	31155-31335	sentence	denotes	In Dmrt7 mutants, the XY body was formed and excluded Cot-1 hybridization (Figure 8B), indicating that transcriptional silencing is established normally in mutant pachytene cells.
T17474	31156-31158	IN	denotes	In
T17475	31190-31196	VBN	denotes	formed
T17476	31159-31164	NN	denotes	Dmrt7
T17477	31165-31172	NNS	denotes	mutants
T17478	31172-31174	,	denotes	,
T17479	31174-31177	DT	denotes	the
T17480	31181-31185	NN	denotes	body
T17481	31178-31180	NN	denotes	XY
T17482	31186-31189	VBD	denotes	was
T17483	31197-31200	CC	denotes	and
T17484	31201-31209	VBD	denotes	excluded
T17485	31210-31213	NN	denotes	Cot
T17486	31216-31229	NN	denotes	hybridization
T17487	31213-31214	HYPH	denotes	-
T17488	31214-31215	CD	denotes	1
T17489	31230-31231	-LRB-	denotes	(
T17490	31238-31240	NN	denotes	8B
T17491	31231-31237	NN	denotes	Figure
T17492	31240-31241	-RRB-	denotes	)
T17493	31241-31243	,	denotes	,
T17494	31243-31253	VBG	denotes	indicating
T17495	31254-31258	IN	denotes	that
T17496	31288-31299	VBN	denotes	established
T17497	31259-31274	JJ	denotes	transcriptional
T17498	31275-31284	NN	denotes	silencing
T17499	31285-31287	VBZ	denotes	is
T17500	31300-31308	RB	denotes	normally
T17501	31309-31311	IN	denotes	in
T17502	31312-31318	NN	denotes	mutant
T17503	31329-31334	NNS	denotes	cells
T17504	31319-31328	NN	denotes	pachytene
T17505	31334-31335	.	denotes	.
T17506	31335-31493	sentence	denotes	We also examined expression of the Y-linked gene Rbmy, which normally is inactivated during pachytene and reactivated after secondary meiosis begins [54,55].
T17507	31336-31338	PRP	denotes	We
T17508	31344-31352	VBD	denotes	examined
T17509	31339-31343	RB	denotes	also
T17510	31353-31363	NN	denotes	expression
T17511	31364-31366	IN	denotes	of
T17512	31367-31370	DT	denotes	the
T17513	31380-31384	NN	denotes	gene
T17514	31371-31372	NN	denotes	Y
T17515	31373-31379	VBN	denotes	linked
T17516	31372-31373	HYPH	denotes	-
T17517	31385-31389	NN	denotes	Rbmy
T17518	31389-31391	,	denotes	,
T17519	31391-31396	WDT	denotes	which
T17520	31409-31420	VBN	denotes	inactivated
T17521	31397-31405	RB	denotes	normally
T17522	31406-31408	VBZ	denotes	is
T17523	31421-31427	IN	denotes	during
T17524	31428-31437	NN	denotes	pachytene
T17525	31438-31441	CC	denotes	and
T17526	31442-31453	VBN	denotes	reactivated
T17527	31454-31459	IN	denotes	after
T17528	31478-31484	VBZ	denotes	begins
T17529	31460-31469	JJ	denotes	secondary
T17530	31470-31477	NN	denotes	meiosis
T17531	31485-31486	-LRB-	denotes	[
T17532	31489-31491	CD	denotes	55
T17533	31486-31488	CD	denotes	54
T17534	31488-31489	,	denotes	,
T17535	31491-31492	-RRB-	denotes	]
T17536	31492-31493	.	denotes	.
T17537	31493-31636	sentence	denotes	Rbmy was inactivated normally in pachytene cells of Dmrt7 mutants, based on immunofluorescent staining with an anti-RBMY antibody (Figure S5).
T17538	31494-31498	NN	denotes	Rbmy
T17539	31503-31514	VBN	denotes	inactivated
T17540	31499-31502	VBD	denotes	was
T17541	31515-31523	RB	denotes	normally
T17542	31524-31526	IN	denotes	in
T17543	31527-31536	NN	denotes	pachytene
T17544	31537-31542	NNS	denotes	cells
T17545	31543-31545	IN	denotes	of
T17546	31546-31551	NN	denotes	Dmrt7
T17547	31552-31559	NNS	denotes	mutants
T17548	31559-31561	,	denotes	,
T17549	31561-31566	VBN	denotes	based
T17550	31567-31569	IN	denotes	on
T17551	31570-31587	JJ	denotes	immunofluorescent
T17552	31588-31596	NN	denotes	staining
T17553	31597-31601	IN	denotes	with
T17554	31602-31604	DT	denotes	an
T17555	31615-31623	NN	denotes	antibody
T17556	31605-31614	JJ	denotes	anti-RBMY
T17557	31624-31625	-LRB-	denotes	(
T17558	31632-31634	NN	denotes	S5
T17559	31625-31631	NN	denotes	Figure
T17560	31634-31635	-RRB-	denotes	)
T17561	31635-31636	.	denotes	.
T17562	31636-31833	sentence	denotes	We also examined heterochromatin protein 1 beta (HP1β), which normally localizes to the X centromere at mid-pachynema and then spreads through the XY body as it internalizes during diplonema [56].
T17563	31637-31639	PRP	denotes	We
T17564	31645-31653	VBD	denotes	examined
T17565	31640-31644	RB	denotes	also
T17566	31654-31669	NN	denotes	heterochromatin
T17567	31680-31684	NN	denotes	beta
T17568	31670-31677	NN	denotes	protein
T17569	31678-31679	CD	denotes	1
T17570	31685-31686	-LRB-	denotes	(
T17571	31686-31690	NN	denotes	HP1β
T17572	31690-31691	-RRB-	denotes	)
T17573	31691-31693	,	denotes	,
T17574	31693-31698	WDT	denotes	which
T17575	31708-31717	VBZ	denotes	localizes
T17578	31721-31724	DT	denotes	the
T17579	31727-31737	NN	denotes	centromere
T17580	31725-31726	NN	denotes	X
T17581	31738-31740	IN	denotes	at
T17582	31741-31754	NN	denotes	mid-pachynema
T17583	31755-31758	CC	denotes	and
T17584	31759-31763	RB	denotes	then
T17585	31764-31771	VBZ	denotes	spreads
T17586	31772-31779	IN	denotes	through
T17587	31780-31783	DT	denotes	the
T17588	31787-31791	NN	denotes	body
T17589	31784-31786	NN	denotes	XY
T17590	31792-31794	IN	denotes	as
T17591	31798-31810	VBZ	denotes	internalizes
T17592	31795-31797	PRP	denotes	it
T17593	31811-31817	IN	denotes	during
T17594	31818-31827	NN	denotes	diplonema
T17595	31828-31829	-LRB-	denotes	[
T17596	31829-31831	CD	denotes	56
T17597	31831-31832	-RRB-	denotes	]
T17598	31832-31833	.	denotes	.
T17599	31833-31934	sentence	denotes	We found that HP1β localization is normal in DMRT7 mutant cells in mid-pachynema (Figure 8C and 8D).
T17600	31834-31836	PRP	denotes	We
T17601	31837-31842	VBD	denotes	found
T17602	31843-31847	IN	denotes	that
T17603	31866-31868	VBZ	denotes	is
T17604	31848-31852	NN	denotes	HP1β
T17605	31853-31865	NN	denotes	localization
T17606	31869-31875	JJ	denotes	normal
T17607	31876-31878	IN	denotes	in
T17608	31879-31884	NN	denotes	DMRT7
T17609	31892-31897	NNS	denotes	cells
T17610	31885-31891	NN	denotes	mutant
T17611	31898-31900	IN	denotes	in
T17612	31901-31914	NN	denotes	mid-pachynema
T17613	31915-31916	-LRB-	denotes	(
T17614	31923-31925	NN	denotes	8C
T17615	31916-31922	NN	denotes	Figure
T17616	31926-31929	CC	denotes	and
T17617	31930-31932	NN	denotes	8D
T17618	31932-31933	-RRB-	denotes	)
T17619	31933-31934	.	denotes	.
T17620	31934-32050	sentence	denotes	These results suggest that XY body formation and initiation of MSCI both occur normally in Dmrt7 mutant germ cells.
T17621	31935-31940	DT	denotes	These
T17622	31941-31948	NNS	denotes	results
T17623	31949-31956	VBP	denotes	suggest
T17624	31957-31961	IN	denotes	that
T17625	32008-32013	VBP	denotes	occur
T17626	31962-31964	NN	denotes	XY
T17627	31970-31979	NN	denotes	formation
T17628	31965-31969	NN	denotes	body
T17629	31980-31983	CC	denotes	and
T17630	31984-31994	NN	denotes	initiation
T17631	31995-31997	IN	denotes	of
T17632	31998-32002	NN	denotes	MSCI
T17633	32003-32007	DT	denotes	both
T17634	32014-32022	RB	denotes	normally
T17635	32023-32025	IN	denotes	in
T17636	32026-32031	NN	denotes	Dmrt7
T17637	32032-32038	NN	denotes	mutant
T17638	32044-32049	NNS	denotes	cells
T17639	32039-32043	NN	denotes	germ
T17640	32049-32050	.	denotes	.
T17641	32050-32051	sentence	denotes
T17642	33335-33489	sentence	denotes	We next considered the possibility that sex chromatin is established normally but is not properly modified as cells exit pachynema and begin to form PMSC.
T17643	33335-33337	PRP	denotes	We
T17644	33343-33353	VBD	denotes	considered
T17645	33338-33342	RB	denotes	next
T17646	33354-33357	DT	denotes	the
T17647	33358-33369	NN	denotes	possibility
T17648	33370-33374	IN	denotes	that
T17649	33392-33403	VBN	denotes	established
T17650	33375-33378	NN	denotes	sex
T17651	33379-33388	NN	denotes	chromatin
T17652	33389-33391	VBZ	denotes	is
T17653	33404-33412	RB	denotes	normally
T17654	33413-33416	CC	denotes	but
T17655	33417-33419	VBZ	denotes	is
T17656	33433-33441	VBN	denotes	modified
T17657	33420-33423	RB	denotes	not
T17658	33424-33432	RB	denotes	properly
T17659	33442-33444	IN	denotes	as
T17660	33451-33455	VBP	denotes	exit
T17661	33445-33450	NNS	denotes	cells
T17662	33456-33465	NN	denotes	pachynema
T17663	33466-33469	CC	denotes	and
T17664	33470-33475	VB	denotes	begin
T17665	33476-33478	TO	denotes	to
T17666	33479-33483	VB	denotes	form
T17667	33484-33488	NN	denotes	PMSC
T17668	33488-33489	.	denotes	.
T17669	33489-33717	sentence	denotes	Although most Dmrt7 mutant cells are eliminated by apoptosis prior to diplonema, we were able to examine epigenetic markers of PMSC in rare Dmrt7 mutant spermatocytes that escaped pachytene arrest and progressed into diplonema.
T17670	33490-33498	IN	denotes	Although
T17671	33527-33537	VBN	denotes	eliminated
T17672	33499-33503	JJS	denotes	most
T17673	33517-33522	NNS	denotes	cells
T17674	33504-33509	NN	denotes	Dmrt7
T17675	33510-33516	NN	denotes	mutant
T17676	33523-33526	VBP	denotes	are
T17677	33574-33578	VBD	denotes	were
T17678	33538-33540	IN	denotes	by
T17679	33541-33550	NN	denotes	apoptosis
T17680	33551-33556	IN	denotes	prior
T17681	33557-33559	IN	denotes	to
T17682	33560-33569	NN	denotes	diplonema
T17683	33569-33571	,	denotes	,
T17684	33571-33573	PRP	denotes	we
T17685	33579-33583	JJ	denotes	able
T17686	33584-33586	TO	denotes	to
T17687	33587-33594	VB	denotes	examine
T17688	33595-33605	JJ	denotes	epigenetic
T17689	33606-33613	NNS	denotes	markers
T17690	33614-33616	IN	denotes	of
T17691	33617-33621	NN	denotes	PMSC
T17692	33622-33624	IN	denotes	in
T17693	33625-33629	JJ	denotes	rare
T17694	33643-33656	NNS	denotes	spermatocytes
T17695	33630-33635	NN	denotes	Dmrt7
T17696	33636-33642	NN	denotes	mutant
T17697	33657-33661	WDT	denotes	that
T17698	33662-33669	VBD	denotes	escaped
T17699	33670-33679	NN	denotes	pachytene
T17700	33680-33686	NN	denotes	arrest
T17701	33687-33690	CC	denotes	and
T17702	33691-33701	VBD	denotes	progressed
T17703	33702-33706	IN	denotes	into
T17704	33707-33716	NN	denotes	diplonema
T17705	33716-33717	.	denotes	.
T17706	33717-33782	sentence	denotes	First, we examined nascent transcription by Cot-1 hybridization.
T17707	33718-33723	RB	denotes	First
T17708	33728-33736	VBD	denotes	examined
T17709	33723-33725	,	denotes	,
T17710	33725-33727	PRP	denotes	we
T17711	33737-33744	JJ	denotes	nascent
T17712	33745-33758	NN	denotes	transcription
T17713	33759-33761	IN	denotes	by
T17714	33762-33765	NN	denotes	Cot
T17715	33768-33781	NN	denotes	hybridization
T17716	33765-33766	HYPH	denotes	-
T17717	33766-33767	CD	denotes	1
T17718	33781-33782	.	denotes	.
T17719	33782-34007	sentence	denotes	Although heterochromatic regions generally showed lower Cot-1 signal than euchromatic regions (Figure 8E and 8F), in some mutant cells the sex chromatin appeared to be incompletely silenced relative to wild-type (Figure 8F).
T17720	33783-33791	IN	denotes	Although
T17721	33826-33832	VBD	denotes	showed
T17722	33792-33807	JJ	denotes	heterochromatic
T17723	33808-33815	NNS	denotes	regions
T17724	33816-33825	RB	denotes	generally
T17725	33936-33944	VBD	denotes	appeared
T17726	33833-33838	JJR	denotes	lower
T17727	33845-33851	NN	denotes	signal
T17728	33839-33842	NN	denotes	Cot
T17729	33842-33843	HYPH	denotes	-
T17730	33843-33844	CD	denotes	1
T17731	33852-33856	IN	denotes	than
T17732	33857-33868	JJ	denotes	euchromatic
T17733	33869-33876	NNS	denotes	regions
T17734	33877-33878	-LRB-	denotes	(
T17735	33885-33887	NN	denotes	8E
T17736	33878-33884	NN	denotes	Figure
T17737	33888-33891	CC	denotes	and
T17738	33892-33894	NN	denotes	8F
T17739	33894-33895	-RRB-	denotes	)
T17740	33895-33897	,	denotes	,
T17741	33897-33899	IN	denotes	in
T17742	33900-33904	DT	denotes	some
T17743	33912-33917	NNS	denotes	cells
T17744	33905-33911	NN	denotes	mutant
T17745	33918-33921	DT	denotes	the
T17746	33926-33935	NN	denotes	chromatin
T17747	33922-33925	NN	denotes	sex
T17748	33945-33947	TO	denotes	to
T17749	33948-33950	VB	denotes	be
T17750	33951-33963	RB	denotes	incompletely
T17751	33964-33972	JJ	denotes	silenced
T17752	33973-33981	JJ	denotes	relative
T17753	33982-33984	IN	denotes	to
T17754	33985-33989	JJ	denotes	wild
T17755	33990-33994	NN	denotes	type
T17756	33989-33990	HYPH	denotes	-
T17757	33995-33996	-LRB-	denotes	(
T17758	34003-34005	NN	denotes	8F
T17759	33996-34002	NN	denotes	Figure
T17760	34005-34006	-RRB-	denotes	)
T17761	34006-34007	.	denotes	.
T17762	34007-34224	sentence	denotes	We also examined three epigenetic signatures of PMSC: histone H3 dimethylated or trimethylated at lysine-9 (H3-2meK9, H3-3meK9) and spreading of HP1β through the XY body [16,57,58] (S. H. Namekawa, unpublished data).
T17763	34008-34010	PRP	denotes	We
T17764	34016-34024	VBD	denotes	examined
T17765	34011-34015	RB	denotes	also
T17766	34025-34030	CD	denotes	three
T17767	34042-34052	NNS	denotes	signatures
T17768	34031-34041	JJ	denotes	epigenetic
T17769	34053-34055	IN	denotes	of
T17770	34056-34060	NN	denotes	PMSC
T17771	34060-34062	:	denotes	:
T17772	34062-34069	NN	denotes	histone
T17773	34070-34072	NN	denotes	H3
T17774	34073-34085	VBN	denotes	dimethylated
T17775	34086-34088	CC	denotes	or
T17776	34089-34102	VBN	denotes	trimethylated
T17777	34103-34105	IN	denotes	at
T17778	34106-34112	NN	denotes	lysine
T17779	34112-34113	HYPH	denotes	-
T17780	34113-34114	CD	denotes	9
T17781	34115-34116	-LRB-	denotes	(
T17782	34119-34124	NN	denotes	2meK9
T17783	34116-34118	NN	denotes	H3
T17784	34118-34119	HYPH	denotes	-
T17785	34124-34126	,	denotes	,
T17786	34126-34128	NN	denotes	H3
T17787	34129-34134	NN	denotes	3meK9
T17788	34128-34129	HYPH	denotes	-
T17789	34134-34135	-RRB-	denotes	)
T17790	34136-34139	CC	denotes	and
T17791	34140-34149	NN	denotes	spreading
T17792	34150-34152	IN	denotes	of
T17793	34153-34157	NN	denotes	HP1β
T17794	34158-34165	IN	denotes	through
T17795	34166-34169	DT	denotes	the
T17796	34173-34177	NN	denotes	body
T17797	34170-34172	NN	denotes	XY
T17798	34178-34179	-LRB-	denotes	[
T17799	34185-34187	CD	denotes	58
T17800	34179-34181	CD	denotes	16
T17801	34181-34182	,	denotes	,
T17802	34182-34184	CD	denotes	57
T17803	34184-34185	,	denotes	,
T17804	34187-34188	-RRB-	denotes	]
T17805	34189-34190	-LRB-	denotes	(
T17806	34190-34192	NNP	denotes	S.
T17807	34193-34195	NNP	denotes	H.
T17808	34196-34204	NNP	denotes	Namekawa
T17809	34204-34206	,	denotes	,
T17810	34206-34217	JJ	denotes	unpublished
T17811	34218-34222	NNS	denotes	data
T17812	34222-34223	-RRB-	denotes	)
T17813	34223-34224	.	denotes	.
T17814	34224-34321	sentence	denotes	We observed defects in sex chromatin localization of all three markers in Dmrt7 diplotene cells.
T17815	34225-34227	PRP	denotes	We
T17816	34228-34236	VBD	denotes	observed
T17817	34237-34244	NNS	denotes	defects
T17818	34245-34247	IN	denotes	in
T17819	34248-34251	NN	denotes	sex
T17820	34252-34261	NN	denotes	chromatin
T17821	34262-34274	NN	denotes	localization
T17822	34275-34277	IN	denotes	of
T17823	34278-34281	DT	denotes	all
T17824	34288-34295	NNS	denotes	markers
T17825	34282-34287	CD	denotes	three
T17826	34296-34298	IN	denotes	in
T17827	34299-34304	NN	denotes	Dmrt7
T17828	34305-34314	NN	denotes	diplotene
T17829	34315-34320	NNS	denotes	cells
T17830	34320-34321	.	denotes	.
T17831	34321-34544	sentence	denotes	Although HP1β localization to the X chromosome centromere initially appeared normal at mid-pachynema, we observed Dmrt7 mutant diplotene cells that failed to show spreading of HP1β to the entire XY body (Figure 8G and 8H).
T17832	34322-34330	IN	denotes	Although
T17833	34390-34398	VBD	denotes	appeared
T17834	34331-34335	NN	denotes	HP1β
T17835	34336-34348	NN	denotes	localization
T17836	34349-34351	IN	denotes	to
T17837	34352-34355	DT	denotes	the
T17838	34369-34379	NN	denotes	centromere
T17839	34356-34357	NN	denotes	X
T17840	34358-34368	NN	denotes	chromosome
T17841	34380-34389	RB	denotes	initially
T17842	34427-34435	VBD	denotes	observed
T17843	34399-34405	JJ	denotes	normal
T17844	34406-34408	IN	denotes	at
T17845	34409-34422	NN	denotes	mid-pachynema
T17846	34422-34424	,	denotes	,
T17847	34424-34426	PRP	denotes	we
T17848	34436-34441	NN	denotes	Dmrt7
T17849	34459-34464	NNS	denotes	cells
T17850	34442-34448	NN	denotes	mutant
T17851	34449-34458	NN	denotes	diplotene
T17852	34465-34469	WDT	denotes	that
T17853	34470-34476	VBD	denotes	failed
T17854	34477-34479	TO	denotes	to
T17855	34480-34484	VB	denotes	show
T17856	34485-34494	NN	denotes	spreading
T17857	34495-34497	IN	denotes	of
T17858	34498-34502	NN	denotes	HP1β
T17859	34503-34505	IN	denotes	to
T17860	34506-34509	DT	denotes	the
T17861	34520-34524	NN	denotes	body
T17862	34510-34516	JJ	denotes	entire
T17863	34517-34519	NN	denotes	XY
T17864	34525-34526	-LRB-	denotes	(
T17865	34533-34535	NN	denotes	8G
T17866	34526-34532	NN	denotes	Figure
T17867	34536-34539	CC	denotes	and
T17868	34540-34542	NN	denotes	8H
T17869	34542-34543	-RRB-	denotes	)
T17870	34543-34544	.	denotes	.
T17871	34544-34684	sentence	denotes	Similarly, we found Dmrt7 mutant diplotene cells lacking accumulation of H3-2meK9 and H3-3meK9 marks onto the sex chromatin (Figure 8I–8L).
T17872	34545-34554	RB	denotes	Similarly
T17873	34559-34564	VBD	denotes	found
T17874	34554-34556	,	denotes	,
T17875	34556-34558	PRP	denotes	we
T17876	34565-34570	NN	denotes	Dmrt7
T17877	34588-34593	NNS	denotes	cells
T17878	34571-34577	NN	denotes	mutant
T17879	34578-34587	NN	denotes	diplotene
T17880	34594-34601	VBG	denotes	lacking
T17881	34602-34614	NN	denotes	accumulation
T17882	34615-34617	IN	denotes	of
T17883	34618-34620	NN	denotes	H3
T17884	34621-34626	NN	denotes	2meK9
T17885	34620-34621	HYPH	denotes	-
T17886	34640-34645	NNS	denotes	marks
T17887	34627-34630	CC	denotes	and
T17888	34631-34633	NN	denotes	H3
T17889	34634-34639	NN	denotes	3meK9
T17890	34633-34634	HYPH	denotes	-
T17891	34646-34650	IN	denotes	onto
T17892	34651-34654	DT	denotes	the
T17893	34659-34668	NN	denotes	chromatin
T17894	34655-34658	NN	denotes	sex
T17895	34669-34670	-LRB-	denotes	(
T17896	34677-34679	NN	denotes	8I
T17897	34670-34676	NN	denotes	Figure
T17898	34679-34680	SYM	denotes	–
T17899	34680-34682	NN	denotes	8L
T17900	34682-34683	-RRB-	denotes	)
T17901	34683-34684	.	denotes	.
T17902	34684-34792	sentence	denotes	Not all Dmrt7 mutant diplotene cells showed abnormal localization of HP1β to the sex chromatin (Figure 8M).
T17903	34685-34688	RB	denotes	Not
T17904	34716-34721	NNS	denotes	cells
T17905	34689-34692	DT	denotes	all
T17906	34693-34698	NN	denotes	Dmrt7
T17907	34699-34705	NN	denotes	mutant
T17908	34706-34715	NN	denotes	diplotene
T17909	34722-34728	VBD	denotes	showed
T17910	34729-34737	JJ	denotes	abnormal
T17911	34738-34750	NN	denotes	localization
T17912	34751-34753	IN	denotes	of
T17913	34754-34758	NN	denotes	HP1β
T17914	34759-34761	IN	denotes	to
T17915	34762-34765	DT	denotes	the
T17916	34770-34779	NN	denotes	chromatin
T17917	34766-34769	NN	denotes	sex
T17918	34780-34781	-LRB-	denotes	(
T17919	34788-34790	NN	denotes	8M
T17920	34781-34787	NN	denotes	Figure
T17921	34790-34791	-RRB-	denotes	)
T17922	34791-34792	.	denotes	.
T17923	34792-34910	sentence	denotes	In one experiment, 11/27 mutant cells in diplonema lacked HP1β on the XY body, as compared with 2/22 wild-type cells.
T17924	34793-34795	IN	denotes	In
T17925	34844-34850	VBD	denotes	lacked
T17926	34796-34799	CD	denotes	one
T17927	34800-34810	NN	denotes	experiment
T17928	34810-34812	,	denotes	,
T17929	34812-34814	CD	denotes	11
T17930	34815-34817	CD	denotes	27
T17931	34814-34815	SYM	denotes	/
T17932	34825-34830	NNS	denotes	cells
T17933	34818-34824	NN	denotes	mutant
T17934	34831-34833	IN	denotes	in
T17935	34834-34843	NN	denotes	diplonema
T17936	34851-34855	NN	denotes	HP1β
T17937	34856-34858	IN	denotes	on
T17938	34859-34862	DT	denotes	the
T17939	34866-34870	NN	denotes	body
T17940	34863-34865	NN	denotes	XY
T17941	34870-34872	,	denotes	,
T17942	34872-34874	IN	denotes	as
T17943	34875-34883	VBN	denotes	compared
T17944	34884-34888	IN	denotes	with
T17945	34889-34890	CD	denotes	2
T17946	34891-34893	CD	denotes	22
T17947	34890-34891	SYM	denotes	/
T17948	34904-34909	NNS	denotes	cells
T17949	34894-34898	JJ	denotes	wild
T17950	34899-34903	NN	denotes	type
T17951	34898-34899	HYPH	denotes	-
T17952	34909-34910	.	denotes	.
T17953	34910-35022	sentence	denotes	We hypothesize that the mutant cells with normal HP1β may be those that can complete meiosis (Figures 4 and 5).
T17954	34911-34913	PRP	denotes	We
T17955	34914-34925	VBP	denotes	hypothesize
T17956	34926-34930	IN	denotes	that
T17957	34969-34971	VB	denotes	be
T17958	34931-34934	DT	denotes	the
T17959	34942-34947	NNS	denotes	cells
T17960	34935-34941	NN	denotes	mutant
T17961	34948-34952	IN	denotes	with
T17962	34953-34959	JJ	denotes	normal
T17963	34960-34964	NN	denotes	HP1β
T17964	34965-34968	MD	denotes	may
T17965	34972-34977	DT	denotes	those
T17966	34978-34982	WDT	denotes	that
T17967	34987-34995	VB	denotes	complete
T17968	34983-34986	MD	denotes	can
T17969	34996-35003	NN	denotes	meiosis
T17970	35004-35005	-LRB-	denotes	(
T17971	35013-35014	CD	denotes	4
T17972	35005-35012	NNS	denotes	Figures
T17973	35015-35018	CC	denotes	and
T17974	35019-35020	CD	denotes	5
T17975	35020-35021	-RRB-	denotes	)
T17976	35021-35022	.	denotes	.
T17977	35022-35144	sentence	denotes	Some of the mutant diplotene cells showing abnormal sex chromatin also had abnormal autosomal γH2AX staining (Figure 8L).
T17978	35023-35027	DT	denotes	Some
T17979	35094-35097	VBD	denotes	had
T17980	35028-35030	IN	denotes	of
T17981	35031-35034	DT	denotes	the
T17982	35052-35057	NNS	denotes	cells
T17983	35035-35041	NN	denotes	mutant
T17984	35042-35051	NN	denotes	diplotene
T17985	35058-35065	VBG	denotes	showing
T17986	35066-35074	JJ	denotes	abnormal
T17987	35079-35088	NN	denotes	chromatin
T17988	35075-35078	NN	denotes	sex
T17989	35089-35093	RB	denotes	also
T17990	35098-35106	JJ	denotes	abnormal
T17991	35123-35131	NN	denotes	staining
T17992	35107-35116	JJ	denotes	autosomal
T17993	35117-35122	NN	denotes	γH2AX
T17994	35132-35133	-LRB-	denotes	(
T17995	35140-35142	NN	denotes	8L
T17996	35133-35139	NN	denotes	Figure
T17997	35142-35143	-RRB-	denotes	)
T17998	35143-35144	.	denotes	.
T17999	35144-35296	sentence	denotes	γH2AX localizes to double-strand DNA breaks, so this staining may indicate that some diplotene mutant cells are approaching or entering apoptosis [59].
T18000	35145-35150	NN	denotes	γH2AX
T18001	35151-35160	VBZ	denotes	localizes
T18002	35161-35163	IN	denotes	to
T18003	35164-35170	JJ	denotes	double
T18004	35171-35177	NN	denotes	strand
T18005	35170-35171	HYPH	denotes	-
T18006	35178-35181	NN	denotes	DNA
T18007	35182-35188	NNS	denotes	breaks
T18008	35188-35190	,	denotes	,
T18009	35190-35192	IN	denotes	so
T18010	35211-35219	VB	denotes	indicate
T18011	35193-35197	DT	denotes	this
T18012	35198-35206	NN	denotes	staining
T18013	35207-35210	MD	denotes	may
T18014	35220-35224	IN	denotes	that
T18015	35257-35268	VBG	denotes	approaching
T18016	35225-35229	DT	denotes	some
T18017	35247-35252	NNS	denotes	cells
T18018	35230-35239	NN	denotes	diplotene
T18019	35240-35246	NN	denotes	mutant
T18020	35253-35256	VBP	denotes	are
T18021	35269-35271	CC	denotes	or
T18022	35272-35280	VBG	denotes	entering
T18023	35281-35290	NN	denotes	apoptosis
T18024	35291-35292	-LRB-	denotes	[
T18025	35292-35294	CD	denotes	59
T18026	35294-35295	-RRB-	denotes	]
T18027	35295-35296	.	denotes	.
T18028	35296-35469	sentence	denotes	We did not observe sex chromatin defects prior to diplonema, but we cannot exclude the possibility that earlier defects exist and the affected cells are rapidly eliminated.
T18029	35297-35299	PRP	denotes	We
T18030	35308-35315	VB	denotes	observe
T18031	35300-35303	VBD	denotes	did
T18032	35304-35307	RB	denotes	not
T18033	35316-35319	NN	denotes	sex
T18034	35330-35337	NNS	denotes	defects
T18035	35320-35329	NN	denotes	chromatin
T18036	35338-35343	IN	denotes	prior
T18037	35344-35346	IN	denotes	to
T18038	35347-35356	NN	denotes	diplonema
T18039	35356-35358	,	denotes	,
T18040	35358-35361	CC	denotes	but
T18041	35362-35364	PRP	denotes	we
T18042	35372-35379	VB	denotes	exclude
T18043	35365-35368	MD	denotes	can
T18044	35368-35371	RB	denotes	not
T18045	35380-35383	DT	denotes	the
T18046	35384-35395	NN	denotes	possibility
T18047	35396-35400	IN	denotes	that
T18048	35417-35422	VBP	denotes	exist
T18049	35401-35408	JJR	denotes	earlier
T18050	35409-35416	NNS	denotes	defects
T18051	35423-35426	CC	denotes	and
T18052	35427-35430	DT	denotes	the
T18053	35440-35445	NNS	denotes	cells
T18054	35431-35439	VBN	denotes	affected
T18055	35458-35468	VBN	denotes	eliminated
T18056	35446-35449	VBP	denotes	are
T18057	35450-35457	RB	denotes	rapidly
T18058	35468-35469	.	denotes	.
T18059	35469-35549	sentence	denotes	In the preceding experiments, we staged cells based on XY body internalization.
T18060	35470-35472	IN	denotes	In
T18061	35503-35509	VBD	denotes	staged
T18062	35473-35476	DT	denotes	the
T18063	35487-35498	NNS	denotes	experiments
T18064	35477-35486	VBG	denotes	preceding
T18065	35498-35500	,	denotes	,
T18066	35500-35502	PRP	denotes	we
T18067	35510-35515	NNS	denotes	cells
T18068	35516-35521	VBN	denotes	based
T18069	35522-35524	IN	denotes	on
T18070	35525-35527	NN	denotes	XY
T18071	35528-35532	NN	denotes	body
T18072	35533-35548	NN	denotes	internalization
T18073	35548-35549	.	denotes	.
T18074	35549-35701	sentence	denotes	Because this process could be abnormal in the mutant cells, we also staged mutant cells by chromosome morphology using an antibody to SYCP3 (Figure 9).
T18075	35550-35557	IN	denotes	Because
T18076	35577-35579	VB	denotes	be
T18077	35558-35562	DT	denotes	this
T18078	35563-35570	NN	denotes	process
T18079	35571-35576	MD	denotes	could
T18080	35618-35624	VBD	denotes	staged
T18081	35580-35588	JJ	denotes	abnormal
T18082	35589-35591	IN	denotes	in
T18083	35592-35595	DT	denotes	the
T18084	35603-35608	NNS	denotes	cells
T18085	35596-35602	NN	denotes	mutant
T18086	35608-35610	,	denotes	,
T18087	35610-35612	PRP	denotes	we
T18088	35613-35617	RB	denotes	also
T18089	35625-35631	NN	denotes	mutant
T18090	35632-35637	NNS	denotes	cells
T18091	35638-35640	IN	denotes	by
T18092	35641-35651	NN	denotes	chromosome
T18093	35652-35662	NN	denotes	morphology
T18094	35663-35668	VBG	denotes	using
T18095	35669-35671	DT	denotes	an
T18096	35672-35680	NN	denotes	antibody
T18097	35681-35683	IN	denotes	to
T18098	35684-35689	NN	denotes	SYCP3
T18099	35690-35691	-LRB-	denotes	(
T18100	35691-35697	NN	denotes	Figure
T18101	35698-35699	CD	denotes	9
T18102	35699-35700	-RRB-	denotes	)
T18103	35700-35701	.	denotes	.
T18104	35701-35836	sentence	denotes	This independently identified Dmrt7 mutant diplotene cells lacking HP1β accumulation in the XY body, such as the example in Figure 9B.
T18105	35702-35706	DT	denotes	This
T18106	35721-35731	VBN	denotes	identified
T18107	35707-35720	RB	denotes	independently
T18108	35732-35737	NN	denotes	Dmrt7
T18109	35738-35744	NN	denotes	mutant
T18110	35755-35760	NNS	denotes	cells
T18111	35745-35754	NN	denotes	diplotene
T18112	35761-35768	VBG	denotes	lacking
T18113	35769-35773	NN	denotes	HP1β
T18114	35774-35786	NN	denotes	accumulation
T18115	35787-35789	IN	denotes	in
T18116	35790-35793	DT	denotes	the
T18117	35797-35801	NN	denotes	body
T18118	35794-35796	NN	denotes	XY
T18119	35801-35803	,	denotes	,
T18120	35803-35807	JJ	denotes	such
T18121	35808-35810	IN	denotes	as
T18122	35811-35814	DT	denotes	the
T18123	35815-35822	NN	denotes	example
T18124	35823-35825	IN	denotes	in
T18125	35826-35832	NN	denotes	Figure
T18126	35833-35835	NN	denotes	9B
T18127	35835-35836	.	denotes	.
T18128	35836-36040	sentence	denotes	From these results, we conclude that Dmrt7 mutant cells establish a normal XY body in mid-pachynema, but then have multiple epigenetic defects in the sex chromatin transition from pachynema to diplonema.
T18129	35837-35841	IN	denotes	From
T18130	35860-35868	VBP	denotes	conclude
T18131	35842-35847	DT	denotes	these
T18132	35848-35855	NNS	denotes	results
T18133	35855-35857	,	denotes	,
T18134	35857-35859	PRP	denotes	we
T18135	35869-35873	IN	denotes	that
T18136	35893-35902	VBP	denotes	establish
T18137	35874-35879	NN	denotes	Dmrt7
T18138	35887-35892	NNS	denotes	cells
T18139	35880-35886	NN	denotes	mutant
T18140	35903-35904	DT	denotes	a
T18141	35915-35919	NN	denotes	body
T18142	35905-35911	JJ	denotes	normal
T18143	35912-35914	NN	denotes	XY
T18144	35920-35922	IN	denotes	in
T18145	35923-35936	NN	denotes	mid-pachynema
T18146	35936-35938	,	denotes	,
T18147	35938-35941	CC	denotes	but
T18148	35942-35946	RB	denotes	then
T18149	35947-35951	VBP	denotes	have
T18150	35952-35960	JJ	denotes	multiple
T18151	35972-35979	NNS	denotes	defects
T18152	35961-35971	JJ	denotes	epigenetic
T18153	35980-35982	IN	denotes	in
T18154	35983-35986	DT	denotes	the
T18155	36001-36011	NN	denotes	transition
T18156	35987-35990	NN	denotes	sex
T18157	35991-36000	NN	denotes	chromatin
T18158	36012-36016	IN	denotes	from
T18159	36017-36026	NN	denotes	pachynema
T18160	36027-36029	IN	denotes	to
T18161	36030-36039	NN	denotes	diplonema
T18162	36039-36040	.	denotes	.
T21499	36505-36507	IN	denotes	In
T21500	36523-36527	VBP	denotes	find
T21501	36508-36512	DT	denotes	this
T21502	36513-36518	NN	denotes	study
T21503	36518-36520	,	denotes	,
T21504	36520-36522	PRP	denotes	we
T21505	36528-36532	IN	denotes	that
T21506	36564-36572	VBN	denotes	required
T21507	36533-36536	DT	denotes	the
T21508	36547-36554	NN	denotes	protein
T21509	36537-36539	NN	denotes	DM
T21510	36540-36546	NN	denotes	domain
T21511	36555-36560	NN	denotes	DMRT7
T21512	36561-36563	VBZ	denotes	is
T21513	36573-36576	IN	denotes	for
T21514	36596-36604	VB	denotes	complete
T21515	36577-36581	JJ	denotes	male
T21516	36587-36592	NNS	denotes	cells
T21517	36582-36586	NN	denotes	germ
T21518	36593-36595	TO	denotes	to
T21519	36605-36612	JJ	denotes	meiotic
T21520	36613-36621	NN	denotes	prophase
T21521	36622-36625	CC	denotes	but
T21522	36626-36628	VBZ	denotes	is
T21523	36629-36640	JJ	denotes	dispensable
T21524	36641-36643	IN	denotes	in
T21525	36644-36647	DT	denotes	the
T21526	36660-36664	NN	denotes	line
T21527	36648-36654	JJ	denotes	female
T21528	36655-36659	NN	denotes	germ
T21529	36664-36665	.	denotes	.
T21530	36665-36788	sentence	denotes	In males, DMRT7 expression is highest in pachytene spermatocytes, and the protein preferentially localizes to the XY body.
T21531	36666-36668	IN	denotes	In
T21532	36693-36695	VBZ	denotes	is
T21533	36669-36674	NNS	denotes	males
T21534	36674-36676	,	denotes	,
T21535	36676-36681	NN	denotes	DMRT7
T21536	36682-36692	NN	denotes	expression
T21537	36696-36703	JJS	denotes	highest
T21538	36704-36706	IN	denotes	in
T21539	36707-36716	NN	denotes	pachytene
T21540	36717-36730	NNS	denotes	spermatocytes
T21541	36730-36732	,	denotes	,
T21542	36732-36735	CC	denotes	and
T21543	36736-36739	DT	denotes	the
T21544	36740-36747	NN	denotes	protein
T21545	36763-36772	VBZ	denotes	localizes
T21546	36748-36762	RB	denotes	preferentially
T21547	36773-36775	IN	denotes	to
T21548	36776-36779	DT	denotes	the
T21549	36783-36787	NN	denotes	body
T21550	36780-36782	NN	denotes	XY
T21551	36787-36788	.	denotes	.
T21552	36788-36982	sentence	denotes	Consistent with this expression, we found that most mutant male germ cells arrest in pachynema and undergo apoptosis, although a small proportion can progress to diplonema and sometimes beyond.
T21553	36789-36799	JJ	denotes	Consistent
T21554	36825-36830	VBD	denotes	found
T21555	36800-36804	IN	denotes	with
T21556	36805-36809	DT	denotes	this
T21557	36810-36820	NN	denotes	expression
T21558	36820-36822	,	denotes	,
T21559	36822-36824	PRP	denotes	we
T21560	36831-36835	IN	denotes	that
T21561	36864-36870	VBP	denotes	arrest
T21562	36836-36840	JJS	denotes	most
T21563	36858-36863	NNS	denotes	cells
T21564	36841-36847	NN	denotes	mutant
T21565	36848-36852	JJ	denotes	male
T21566	36853-36857	NN	denotes	germ
T21567	36871-36873	IN	denotes	in
T21568	36874-36883	NN	denotes	pachynema
T21569	36884-36887	CC	denotes	and
T21570	36888-36895	VBP	denotes	undergo
T21571	36896-36905	NN	denotes	apoptosis
T21572	36905-36907	,	denotes	,
T21573	36907-36915	IN	denotes	although
T21574	36939-36947	VB	denotes	progress
T21575	36916-36917	DT	denotes	a
T21576	36924-36934	NN	denotes	proportion
T21577	36918-36923	JJ	denotes	small
T21578	36935-36938	MD	denotes	can
T21579	36948-36950	IN	denotes	to
T21580	36951-36960	NN	denotes	diplonema
T21581	36961-36964	CC	denotes	and
T21582	36965-36974	RB	denotes	sometimes
T21583	36975-36981	RB	denotes	beyond
T21584	36981-36982	.	denotes	.
T21585	36982-37136	sentence	denotes	Examination of chromatin and nascent transcription in mutant cells that progressed to diplonema revealed sex chromatin abnormalities, as discussed below.
T21586	36983-36994	NN	denotes	Examination
T21587	37079-37087	VBD	denotes	revealed
T21588	36995-36997	IN	denotes	of
T21589	36998-37007	NN	denotes	chromatin
T21590	37008-37011	CC	denotes	and
T21591	37012-37019	JJ	denotes	nascent
T21592	37020-37033	NN	denotes	transcription
T21593	37034-37036	IN	denotes	in
T21594	37037-37043	NN	denotes	mutant
T21595	37044-37049	NNS	denotes	cells
T21596	37050-37054	WDT	denotes	that
T21597	37055-37065	VBD	denotes	progressed
T21598	37066-37068	IN	denotes	to
T21599	37069-37078	NN	denotes	diplonema
T21600	37088-37091	NN	denotes	sex
T21601	37092-37101	NN	denotes	chromatin
T21602	37102-37115	NNS	denotes	abnormalities
T21603	37115-37117	,	denotes	,
T21604	37117-37119	IN	denotes	as
T21605	37120-37129	VBN	denotes	discussed
T21606	37130-37135	RB	denotes	below
T21607	37135-37136	.	denotes	.
T21608	37136-37255	sentence	denotes	The pachytene stage of prophase involves tremendous chromosomal changes as the homologs align, synapse, and recombine.
T21609	37137-37140	DT	denotes	The
T21610	37151-37156	NN	denotes	stage
T21611	37141-37150	NN	denotes	pachytene
T21612	37169-37177	VBZ	denotes	involves
T21613	37157-37159	IN	denotes	of
T21614	37160-37168	NN	denotes	prophase
T21615	37178-37188	JJ	denotes	tremendous
T21616	37201-37208	NNS	denotes	changes
T21617	37189-37200	JJ	denotes	chromosomal
T21618	37209-37211	IN	denotes	as
T21619	37225-37230	VBP	denotes	align
T21620	37212-37215	DT	denotes	the
T21621	37216-37224	NNS	denotes	homologs
T21622	37230-37232	,	denotes	,
T21623	37232-37239	VBP	denotes	synapse
T21624	37239-37241	,	denotes	,
T21625	37241-37244	CC	denotes	and
T21626	37245-37254	VBP	denotes	recombine
T21627	37254-37255	.	denotes	.
T21628	37255-37371	sentence	denotes	During this period, at least one pachytene surveillance system exists to monitor key events of meiotic progression.
T21629	37256-37262	IN	denotes	During
T21630	37319-37325	VBZ	denotes	exists
T21631	37263-37267	DT	denotes	this
T21632	37268-37274	NN	denotes	period
T21633	37274-37276	,	denotes	,
T21634	37276-37278	RB	denotes	at
T21635	37285-37288	CD	denotes	one
T21636	37279-37284	RBS	denotes	least
T21637	37312-37318	NN	denotes	system
T21638	37289-37298	NN	denotes	pachytene
T21639	37299-37311	NN	denotes	surveillance
T21640	37326-37328	TO	denotes	to
T21641	37329-37336	VB	denotes	monitor
T21642	37337-37340	JJ	denotes	key
T21643	37341-37347	NNS	denotes	events
T21644	37348-37350	IN	denotes	of
T21645	37351-37358	JJ	denotes	meiotic
T21646	37359-37370	NN	denotes	progression
T21647	37370-37371	.	denotes	.
T21648	37371-37465	sentence	denotes	Cells in which any of these events is anomalous are efficiently eliminated by apoptosis [46].
T21649	37372-37377	NNS	denotes	Cells
T21650	37436-37446	VBN	denotes	eliminated
T21651	37378-37380	IN	denotes	in
T21652	37407-37409	VBZ	denotes	is
T21653	37381-37386	WDT	denotes	which
T21654	37387-37390	DT	denotes	any
T21655	37391-37393	IN	denotes	of
T21656	37394-37399	DT	denotes	these
T21657	37400-37406	NNS	denotes	events
T21658	37410-37419	JJ	denotes	anomalous
T21659	37420-37423	VBP	denotes	are
T21660	37424-37435	RB	denotes	efficiently
T21661	37447-37449	IN	denotes	by
T21662	37450-37459	NN	denotes	apoptosis
T21663	37460-37461	-LRB-	denotes	[
T21664	37461-37463	CD	denotes	46
T21665	37463-37464	-RRB-	denotes	]
T21666	37464-37465	.	denotes	.
T21667	37465-37600	sentence	denotes	Another key event of pachynema in male mammals is the packaging of the sex chromosomes into the XY body and the establishment of MSCI.
T21668	37466-37473	DT	denotes	Another
T21669	37478-37483	NN	denotes	event
T21670	37474-37477	JJ	denotes	key
T21671	37513-37515	VBZ	denotes	is
T21672	37484-37486	IN	denotes	of
T21673	37487-37496	NN	denotes	pachynema
T21674	37497-37499	IN	denotes	in
T21675	37500-37504	JJ	denotes	male
T21676	37505-37512	NNS	denotes	mammals
T21677	37516-37519	DT	denotes	the
T21678	37520-37529	NN	denotes	packaging
T21679	37530-37532	IN	denotes	of
T21680	37533-37536	DT	denotes	the
T21681	37541-37552	NNS	denotes	chromosomes
T21682	37537-37540	NN	denotes	sex
T21683	37553-37557	IN	denotes	into
T21684	37558-37561	DT	denotes	the
T21685	37565-37569	NN	denotes	body
T21686	37562-37564	NN	denotes	XY
T21687	37570-37573	CC	denotes	and
T21688	37574-37577	DT	denotes	the
T21689	37578-37591	NN	denotes	establishment
T21690	37592-37594	IN	denotes	of
T21691	37595-37599	NN	denotes	MSCI
T21692	37599-37600	.	denotes	.
T21693	37600-37803	sentence	denotes	Examination of male meiosis in XYY mice and mice carrying a sex-chromosome-to-autosome translocation showed that cells in which a sex chromosome escapes MSCI are eliminated prior to late-pachynema [17].
T21694	37601-37612	NN	denotes	Examination
T21695	37702-37708	VBD	denotes	showed
T21696	37613-37615	IN	denotes	of
T21697	37616-37620	JJ	denotes	male
T21698	37621-37628	NN	denotes	meiosis
T21699	37629-37631	IN	denotes	in
T21700	37632-37635	NN	denotes	XYY
T21701	37636-37640	NNS	denotes	mice
T21702	37641-37644	CC	denotes	and
T21703	37645-37649	NNS	denotes	mice
T21704	37650-37658	VBG	denotes	carrying
T21705	37659-37660	DT	denotes	a
T21706	37688-37701	NN	denotes	translocation
T21707	37661-37664	NN	denotes	sex
T21708	37665-37675	NN	denotes	chromosome
T21709	37664-37665	HYPH	denotes	-
T21710	37675-37676	HYPH	denotes	-
T21711	37676-37678	IN	denotes	to
T21712	37678-37679	HYPH	denotes	-
T21713	37679-37687	NN	denotes	autosome
T21714	37709-37713	IN	denotes	that
T21715	37763-37773	VBN	denotes	eliminated
T21716	37714-37719	NNS	denotes	cells
T21717	37720-37722	IN	denotes	in
T21718	37746-37753	VBZ	denotes	escapes
T21719	37723-37728	WDT	denotes	which
T21720	37729-37730	DT	denotes	a
T21721	37735-37745	NN	denotes	chromosome
T21722	37731-37734	NN	denotes	sex
T21723	37754-37758	NN	denotes	MSCI
T21724	37759-37762	VBP	denotes	are
T21725	37774-37779	IN	denotes	prior
T21726	37780-37782	IN	denotes	to
T21727	37783-37787	JJ	denotes	late
T21728	37788-37797	NN	denotes	pachynema
T21729	37787-37788	HYPH	denotes	-
T21730	37798-37799	-LRB-	denotes	[
T21731	37799-37801	CD	denotes	17
T21732	37801-37802	-RRB-	denotes	]
T21733	37802-37803	.	denotes	.
T21734	37803-37882	sentence	denotes	This indicates that the establishment of MSCI also is subject to surveillance.
T21735	37804-37808	DT	denotes	This
T21736	37809-37818	VBZ	denotes	indicates
T21737	37819-37823	IN	denotes	that
T21738	37855-37857	VBZ	denotes	is
T21739	37824-37827	DT	denotes	the
T21740	37828-37841	NN	denotes	establishment
T21741	37842-37844	IN	denotes	of
T21742	37845-37849	NN	denotes	MSCI
T21743	37850-37854	RB	denotes	also
T21744	37858-37865	JJ	denotes	subject
T21745	37866-37868	IN	denotes	to
T21746	37869-37881	NN	denotes	surveillance
T21747	37881-37882	.	denotes	.
T21748	37882-38092	sentence	denotes	Since the arrest and apoptosis of Dmrt7 mutant spermatocytes could result from perturbation of any of the critical pachytene events mentioned above, we tested whether they occur abnormally in the mutant cells.
T21749	37883-37888	IN	denotes	Since
T21750	37950-37956	VB	denotes	result
T21751	37889-37892	DT	denotes	the
T21752	37893-37899	NN	denotes	arrest
T21753	37900-37903	CC	denotes	and
T21754	37904-37913	NN	denotes	apoptosis
T21755	37914-37916	IN	denotes	of
T21756	37917-37922	NN	denotes	Dmrt7
T21757	37923-37929	NN	denotes	mutant
T21758	37930-37943	NNS	denotes	spermatocytes
T21759	37944-37949	MD	denotes	could
T21760	38035-38041	VBD	denotes	tested
T21761	37957-37961	IN	denotes	from
T21762	37962-37974	NN	denotes	perturbation
T21763	37975-37977	IN	denotes	of
T21764	37978-37981	DT	denotes	any
T21765	37982-37984	IN	denotes	of
T21766	37985-37988	DT	denotes	the
T21767	38008-38014	NNS	denotes	events
T21768	37989-37997	JJ	denotes	critical
T21769	37998-38007	NN	denotes	pachytene
T21770	38015-38024	VBN	denotes	mentioned
T21771	38025-38030	RB	denotes	above
T21772	38030-38032	,	denotes	,
T21773	38032-38034	PRP	denotes	we
T21774	38042-38049	IN	denotes	whether
T21775	38055-38060	VBP	denotes	occur
T21776	38050-38054	PRP	denotes	they
T21777	38061-38071	RB	denotes	abnormally
T21778	38072-38074	IN	denotes	in
T21779	38075-38078	DT	denotes	the
T21780	38086-38091	NNS	denotes	cells
T21781	38079-38085	NN	denotes	mutant
T21782	38091-38092	.	denotes	.
T21783	38092-38182	sentence	denotes	We found that chromosomal synapsis and recombination appear normal in Dmrt7 mutant cells.
T21784	38093-38095	PRP	denotes	We
T21785	38096-38101	VBD	denotes	found
T21786	38102-38106	IN	denotes	that
T21787	38146-38152	VBP	denotes	appear
T21788	38107-38118	JJ	denotes	chromosomal
T21789	38119-38127	NN	denotes	synapsis
T21790	38128-38131	CC	denotes	and
T21795	38169-38175	NN	denotes	mutant
T21796	38176-38181	NNS	denotes	cells
T21797	38181-38182	.	denotes	.
T21798	38182-38266	sentence	denotes	We therefore focused on the XY body, the most prominent site of DMRT7 accumulation.
T21799	38183-38185	PRP	denotes	We
T21800	38196-38203	VBD	denotes	focused
T21801	38186-38195	RB	denotes	therefore
T21802	38204-38206	IN	denotes	on
T21803	38207-38210	DT	denotes	the
T21804	38214-38218	NN	denotes	body
T21805	38211-38213	NN	denotes	XY
T21806	38218-38220	,	denotes	,
T21807	38220-38223	DT	denotes	the
T21808	38239-38243	NN	denotes	site
T21809	38224-38228	RBS	denotes	most
T21810	38229-38238	JJ	denotes	prominent
T21811	38244-38246	IN	denotes	of
T21812	38247-38252	NN	denotes	DMRT7
T21813	38253-38265	NN	denotes	accumulation
T21814	38265-38266	.	denotes	.
T21815	38266-38356	sentence	denotes	First, we tested whether the XY body forms and MSCI is established in Dmrt7 mutant cells.
T21816	38267-38272	RB	denotes	First
T21817	38277-38283	VBD	denotes	tested
T21818	38272-38274	,	denotes	,
T21819	38274-38276	PRP	denotes	we
T21820	38284-38291	IN	denotes	whether
T21821	38304-38309	VBZ	denotes	forms
T21822	38292-38295	DT	denotes	the
T21823	38299-38303	NN	denotes	body
T21824	38296-38298	NN	denotes	XY
T21825	38310-38313	CC	denotes	and
T21826	38314-38318	NN	denotes	MSCI
T21827	38322-38333	VBN	denotes	established
T21828	38319-38321	VBZ	denotes	is
T21829	38334-38336	IN	denotes	in
T21830	38337-38342	NN	denotes	Dmrt7
T21831	38343-38349	NN	denotes	mutant
T21832	38350-38355	NNS	denotes	cells
T21833	38355-38356	.	denotes	.
T21834	38356-38499	sentence	denotes	Surprisingly, we found that these cells form an XY body with normal morphology and proper accumulation of all the chromatin marks we examined.
T21835	38357-38369	RB	denotes	Surprisingly
T21836	38374-38379	VBD	denotes	found
T21837	38369-38371	,	denotes	,
T21838	38371-38373	PRP	denotes	we
T21839	38380-38384	IN	denotes	that
T21840	38397-38401	VBP	denotes	form
T21841	38385-38390	DT	denotes	these
T21842	38391-38396	NNS	denotes	cells
T21843	38402-38404	DT	denotes	an
T21844	38408-38412	NN	denotes	body
T21845	38405-38407	NN	denotes	XY
T21846	38413-38417	IN	denotes	with
T21847	38418-38424	JJ	denotes	normal
T21848	38425-38435	NN	denotes	morphology
T21849	38436-38439	CC	denotes	and
T21850	38440-38446	JJ	denotes	proper
T21851	38447-38459	NN	denotes	accumulation
T21852	38460-38462	IN	denotes	of
T21853	38463-38466	PDT	denotes	all
T21854	38481-38486	NNS	denotes	marks
T21855	38467-38470	DT	denotes	the
T21856	38471-38480	NN	denotes	chromatin
T21857	38487-38489	PRP	denotes	we
T21858	38490-38498	VBD	denotes	examined
T21859	38498-38499	.	denotes	.
T21860	38499-38655	sentence	denotes	Moreover, Cot-1 hybridization and analysis of RBMY expression demonstrated that MSCI initiates normally in the XY body of mid-pachytene Dmrt7 mutant cells.
T21861	38500-38508	RB	denotes	Moreover
T21862	38562-38574	VBD	denotes	demonstrated
T21863	38508-38510	,	denotes	,
T21864	38510-38513	NN	denotes	Cot
T21865	38516-38529	NN	denotes	hybridization
T21866	38513-38514	HYPH	denotes	-
T21867	38514-38515	CD	denotes	1
T21868	38530-38533	CC	denotes	and
T21869	38534-38542	NN	denotes	analysis
T21870	38543-38545	IN	denotes	of
T21871	38546-38550	NN	denotes	RBMY
T21872	38551-38561	NN	denotes	expression
T21873	38575-38579	IN	denotes	that
T21874	38585-38594	VBZ	denotes	initiates
T21875	38580-38584	NN	denotes	MSCI
T21876	38595-38603	RB	denotes	normally
T21877	38604-38606	IN	denotes	in
T21878	38607-38610	DT	denotes	the
T21879	38614-38618	NN	denotes	body
T21880	38611-38613	NN	denotes	XY
T21881	38619-38621	IN	denotes	of
T21882	38622-38635	NN	denotes	mid-pachytene
T21883	38649-38654	NNS	denotes	cells
T21884	38636-38641	NN	denotes	Dmrt7
T21885	38642-38648	NN	denotes	mutant
T21886	38654-38655	.	denotes	.
T21887	38655-38818	sentence	denotes	We did, however, observe three specific defects in the sex chromatin of Dmrt7 mutant germ cells that avoided arrest in pachynema and were able to enter diplonema.
T21888	38656-38658	PRP	denotes	We
T21889	38673-38680	VB	denotes	observe
T21890	38659-38662	VBD	denotes	did
T21891	38662-38664	,	denotes	,
T21892	38664-38671	RB	denotes	however
T21893	38671-38673	,	denotes	,
T21894	38681-38686	CD	denotes	three
T21895	38696-38703	NNS	denotes	defects
T21896	38687-38695	JJ	denotes	specific
T21897	38704-38706	IN	denotes	in
T21898	38707-38710	DT	denotes	the
T21899	38715-38724	NN	denotes	chromatin
T21900	38711-38714	NN	denotes	sex
T21901	38725-38727	IN	denotes	of
T21902	38728-38733	NN	denotes	Dmrt7
T21903	38734-38740	NN	denotes	mutant
T21904	38746-38751	NNS	denotes	cells
T21905	38741-38745	NN	denotes	germ
T21906	38752-38756	WDT	denotes	that
T21907	38757-38764	VBD	denotes	avoided
T21908	38765-38771	NN	denotes	arrest
T21909	38772-38774	IN	denotes	in
T21910	38775-38784	NN	denotes	pachynema
T21911	38785-38788	CC	denotes	and
T21912	38789-38793	VBD	denotes	were
T21913	38794-38798	JJ	denotes	able
T21914	38799-38801	TO	denotes	to
T21915	38802-38807	VB	denotes	enter
T21916	38808-38817	NN	denotes	diplonema
T21917	38817-38818	.	denotes	.
T21918	38818-39004	sentence	denotes	Normally cells accumulate H3-2meK9 and H3-3meK9 marks and HP1β protein on the sex chromatin as they progress to diplonema, but we observed mutant diplotene cells lacking these features.
T21919	38819-38827	RB	denotes	Normally
T21920	38834-38844	VBP	denotes	accumulate
T21921	38828-38833	NNS	denotes	cells
T21922	38845-38847	NN	denotes	H3
T21923	38848-38853	NN	denotes	2meK9
T21924	38847-38848	HYPH	denotes	-
T21925	38867-38872	NNS	denotes	marks
T21926	38854-38857	CC	denotes	and
T21927	38858-38860	NN	denotes	H3
T21928	38861-38866	NN	denotes	3meK9
T21929	38860-38861	HYPH	denotes	-
T21930	38873-38876	CC	denotes	and
T21931	38877-38881	NN	denotes	HP1β
T21932	38882-38889	NN	denotes	protein
T21933	38890-38892	IN	denotes	on
T21934	38893-38896	DT	denotes	the
T21935	38901-38910	NN	denotes	chromatin
T21936	38897-38900	NN	denotes	sex
T21937	38911-38913	IN	denotes	as
T21938	38919-38927	VBP	denotes	progress
T21939	38914-38918	PRP	denotes	they
T21940	38928-38930	IN	denotes	to
T21941	38931-38940	NN	denotes	diplonema
T21942	38940-38942	,	denotes	,
T21943	38942-38945	CC	denotes	but
T21944	38946-38948	PRP	denotes	we
T21945	38949-38957	VBD	denotes	observed
T21946	38958-38964	NN	denotes	mutant
T21947	38975-38980	NNS	denotes	cells
T21948	38965-38974	NN	denotes	diplotene
T21949	38981-38988	VBG	denotes	lacking
T21950	38989-38994	DT	denotes	these
T21951	38995-39003	NNS	denotes	features
T21952	39003-39004	.	denotes	.
T21953	39004-39170	sentence	denotes	Thus, although a minority of Dmrt7 mutant germ cells can progress from pachynema to diplonema, there are defects in sex chromatin modification during the transition.
T21954	39005-39009	RB	denotes	Thus
T21955	39106-39109	VBP	denotes	are
T21956	39009-39011	,	denotes	,
T21957	39011-39019	IN	denotes	although
T21958	39062-39070	VB	denotes	progress
T21959	39020-39021	DT	denotes	a
T21960	39022-39030	NN	denotes	minority
T21961	39031-39033	IN	denotes	of
T21962	39034-39039	NN	denotes	Dmrt7
T21963	39040-39046	NN	denotes	mutant
T21964	39052-39057	NNS	denotes	cells
T21965	39047-39051	NN	denotes	germ
T21966	39058-39061	MD	denotes	can
T21967	39071-39075	IN	denotes	from
T21968	39076-39085	NN	denotes	pachynema
T21969	39086-39088	IN	denotes	to
T21970	39089-39098	NN	denotes	diplonema
T21971	39098-39100	,	denotes	,
T21972	39100-39105	EX	denotes	there
T21973	39110-39117	NNS	denotes	defects
T21974	39118-39120	IN	denotes	in
T21975	39121-39124	NN	denotes	sex
T21976	39125-39134	NN	denotes	chromatin
T21977	39135-39147	NN	denotes	modification
T21978	39148-39154	IN	denotes	during
T21979	39155-39158	DT	denotes	the
T21980	39159-39169	NN	denotes	transition
T21981	39169-39170	.	denotes	.
T21982	39170-39317	sentence	denotes	A function in male sex chromatin can reconcile the findings that DMRT7 is required for meiosis, but only in males, and is present only in mammals.
T21983	39171-39172	DT	denotes	A
T21984	39173-39181	NN	denotes	function
T21985	39208-39217	VB	denotes	reconcile
T21986	39182-39184	IN	denotes	in
T21987	39185-39189	JJ	denotes	male
T21988	39194-39203	NN	denotes	chromatin
T21989	39190-39193	NN	denotes	sex
T21990	39204-39207	MD	denotes	can
T21991	39218-39221	DT	denotes	the
T21992	39222-39230	NNS	denotes	findings
T21993	39231-39235	IN	denotes	that
T21994	39245-39253	VBN	denotes	required
T21995	39236-39241	NN	denotes	DMRT7
T21996	39242-39244	VBZ	denotes	is
T21997	39254-39257	IN	denotes	for
T21998	39258-39265	NN	denotes	meiosis
T21999	39265-39267	,	denotes	,
T22000	39267-39270	CC	denotes	but
T22001	39271-39275	RB	denotes	only
T22002	39276-39278	IN	denotes	in
T22003	39279-39284	NNS	denotes	males
T22004	39284-39286	,	denotes	,
T22005	39286-39289	CC	denotes	and
T22006	39290-39292	VBZ	denotes	is
T22007	39293-39300	JJ	denotes	present
T22008	39301-39305	RB	denotes	only
T22009	39306-39308	IN	denotes	in
T22010	39309-39316	NNS	denotes	mammals
T22011	39316-39317	.	denotes	.
T22012	39317-39488	sentence	denotes	A proportion of mutant diplotene cells have apparently normal sex chromatin (for example, Figure 8M); these are likely to be the cells that can progress beyond diplonema.
T22013	39318-39319	DT	denotes	A
T22014	39320-39330	NN	denotes	proportion
T22015	39357-39361	VBP	denotes	have
T22016	39331-39333	IN	denotes	of
T22017	39334-39340	NN	denotes	mutant
T22018	39351-39356	NNS	denotes	cells
T22019	39341-39350	NN	denotes	diplotene
T22020	39426-39429	VBP	denotes	are
T22021	39362-39372	RB	denotes	apparently
T22022	39373-39379	JJ	denotes	normal
T22023	39384-39393	NN	denotes	chromatin
T22024	39380-39383	NN	denotes	sex
T22025	39394-39395	-LRB-	denotes	(
T22026	39415-39417	NN	denotes	8M
T22027	39395-39398	IN	denotes	for
T22028	39399-39406	NN	denotes	example
T22029	39406-39408	,	denotes	,
T22030	39408-39414	NN	denotes	Figure
T22031	39417-39418	-RRB-	denotes	)
T22032	39418-39419	:	denotes	;
T22033	39420-39425	DT	denotes	these
T22034	39430-39436	JJ	denotes	likely
T22035	39437-39439	TO	denotes	to
T22036	39440-39442	VB	denotes	be
T22037	39443-39446	DT	denotes	the
T22038	39447-39452	NNS	denotes	cells
T22039	39453-39457	WDT	denotes	that
T22040	39462-39470	VB	denotes	progress
T22041	39458-39461	MD	denotes	can
T22042	39471-39477	IN	denotes	beyond
T22043	39478-39487	NN	denotes	diplonema
T22044	39487-39488	.	denotes	.
T22045	39488-39697	sentence	denotes	Because most Dmrt7 mutant germ cells are eliminated by apoptosis around the time at which we observed sex chromatin defects, a simple model is that the apoptosis is a consequence of the sex chromatin defects.
T22046	39489-39496	IN	denotes	Because
T22047	39530-39540	VBN	denotes	eliminated
T22048	39497-39501	JJS	denotes	most
T22049	39520-39525	NNS	denotes	cells
T22050	39502-39507	NN	denotes	Dmrt7
T22051	39508-39514	NN	denotes	mutant
T22052	39515-39519	NN	denotes	germ
T22053	39526-39529	VBP	denotes	are
T22054	39629-39631	VBZ	denotes	is
T22055	39541-39543	IN	denotes	by
T22056	39544-39553	NN	denotes	apoptosis
T22057	39554-39560	IN	denotes	around
T22058	39561-39564	DT	denotes	the
T22059	39565-39569	NN	denotes	time
T22060	39570-39572	IN	denotes	at
T22061	39582-39590	VBD	denotes	observed
T22062	39573-39578	WDT	denotes	which
T22063	39579-39581	PRP	denotes	we
T22064	39591-39594	NN	denotes	sex
T22065	39605-39612	NNS	denotes	defects
T22066	39595-39604	NN	denotes	chromatin
T22067	39612-39614	,	denotes	,
T22068	39614-39615	DT	denotes	a
T22069	39623-39628	NN	denotes	model
T22070	39616-39622	JJ	denotes	simple
T22071	39632-39636	IN	denotes	that
T22072	39651-39653	VBZ	denotes	is
T22073	39637-39640	DT	denotes	the
T22074	39641-39650	NN	denotes	apoptosis
T22075	39654-39655	DT	denotes	a
T22076	39656-39667	NN	denotes	consequence
T22077	39668-39670	IN	denotes	of
T22078	39671-39674	DT	denotes	the
T22079	39689-39696	NNS	denotes	defects
T22080	39675-39678	NN	denotes	sex
T22081	39679-39688	NN	denotes	chromatin
T22082	39696-39697	.	denotes	.
T22083	39697-39892	sentence	denotes	The reciprocal situation (sex chromatin defects caused by apoptosis) is possible, but seems unlikely, because we observed mutant cells with sex chromatin defects but no indications of apoptosis.
T22084	39698-39701	DT	denotes	The
T22085	39713-39722	NN	denotes	situation
T22086	39702-39712	JJ	denotes	reciprocal
T22087	39767-39769	VBZ	denotes	is
T22088	39723-39724	-LRB-	denotes	(
T22089	39738-39745	NNS	denotes	defects
T22090	39724-39727	NN	denotes	sex
T22091	39728-39737	NN	denotes	chromatin
T22092	39746-39752	VBN	denotes	caused
T22093	39753-39755	IN	denotes	by
T22094	39756-39765	NN	denotes	apoptosis
T22095	39765-39766	-RRB-	denotes	)
T22096	39770-39778	JJ	denotes	possible
T22097	39778-39780	,	denotes	,
T22098	39780-39783	CC	denotes	but
T22099	39784-39789	VBZ	denotes	seems
T22100	39790-39798	JJ	denotes	unlikely
T22101	39798-39800	,	denotes	,
T22102	39800-39807	IN	denotes	because
T22103	39811-39819	VBD	denotes	observed
T22104	39808-39810	PRP	denotes	we
T22105	39820-39826	NN	denotes	mutant
T22106	39827-39832	NNS	denotes	cells
T22107	39833-39837	IN	denotes	with
T22108	39838-39841	NN	denotes	sex
T22109	39842-39851	NN	denotes	chromatin
T22110	39852-39859	NNS	denotes	defects
T22111	39860-39863	CC	denotes	but
T22112	39864-39866	DT	denotes	no
T22113	39867-39878	NNS	denotes	indications
T22114	39879-39881	IN	denotes	of
T22115	39882-39891	NN	denotes	apoptosis
T22116	39891-39892	.	denotes	.
T22117	39892-39995	sentence	denotes	Alternatively, apoptosis and abnormal sex chromatin may be two independent consequences of Dmrt7 loss.
T22118	39893-39906	RB	denotes	Alternatively
T22119	39949-39951	VB	denotes	be
T22120	39906-39908	,	denotes	,
T22121	39908-39917	NN	denotes	apoptosis
T22122	39918-39921	CC	denotes	and
T22123	39922-39930	JJ	denotes	abnormal
T22124	39935-39944	NN	denotes	chromatin
T22125	39931-39934	NN	denotes	sex
T22126	39945-39948	MD	denotes	may
T22127	39952-39955	CD	denotes	two
T22128	39968-39980	NNS	denotes	consequences
T22129	39956-39967	JJ	denotes	independent
T22130	39981-39983	IN	denotes	of
T22131	39984-39989	NN	denotes	Dmrt7
T22132	39990-39994	NN	denotes	loss
T22133	39994-39995	.	denotes	.
T22134	39995-40098	sentence	denotes	This question cannot be answered definitively until we know the detailed molecular mechanism of DMRT7.
T22135	39996-40000	DT	denotes	This
T22136	40001-40009	NN	denotes	question
T22137	40020-40028	VBN	denotes	answered
T22138	40010-40013	MD	denotes	can
T22139	40013-40016	RB	denotes	not
T22140	40017-40019	VB	denotes	be
T22141	40029-40041	RB	denotes	definitively
T22142	40042-40047	IN	denotes	until
T22143	40051-40055	VBP	denotes	know
T22144	40048-40050	PRP	denotes	we
T22145	40056-40059	DT	denotes	the
T22146	40079-40088	NN	denotes	mechanism
T22147	40060-40068	JJ	denotes	detailed
T22148	40069-40078	JJ	denotes	molecular
T22149	40089-40091	IN	denotes	of
T22150	40092-40097	NN	denotes	DMRT7
T22151	40097-40098	.	denotes	.
T22152	40098-40380	sentence	denotes	A number of other proteins have been identified that interact with the XY body, including histone variants and modified histones, a testis-specific histone methyl transferase, chromobox proteins, an orphan receptor germ-cell nuclear factor, and recombination-related proteins [60].
T22153	40099-40100	DT	denotes	A
T22154	40101-40107	NN	denotes	number
T22155	40136-40146	VBN	denotes	identified
T22156	40108-40110	IN	denotes	of
T22157	40111-40116	JJ	denotes	other
T22158	40117-40125	NN	denotes	proteins
T22159	40126-40130	VBP	denotes	have
T22160	40131-40135	VBN	denotes	been
T22161	40147-40151	WDT	denotes	that
T22162	40152-40160	VBP	denotes	interact
T22163	40161-40165	IN	denotes	with
T22164	40166-40169	DT	denotes	the
T22165	40173-40177	NN	denotes	body
T22166	40170-40172	NN	denotes	XY
T22167	40177-40179	,	denotes	,
T22168	40179-40188	VBG	denotes	including
T22169	40189-40196	NN	denotes	histone
T22170	40197-40205	NNS	denotes	variants
T22171	40206-40209	CC	denotes	and
T22172	40210-40218	VBN	denotes	modified
T22173	40219-40227	NNS	denotes	histones
T22174	40227-40229	,	denotes	,
T22175	40229-40230	DT	denotes	a
T22176	40262-40273	NN	denotes	transferase
T22177	40231-40237	NN	denotes	testis
T22178	40238-40246	JJ	denotes	specific
T22179	40237-40238	HYPH	denotes	-
T22180	40247-40254	NN	denotes	histone
T22181	40255-40261	NN	denotes	methyl
T22182	40273-40275	,	denotes	,
T22183	40275-40284	NN	denotes	chromobox
T22184	40285-40293	NN	denotes	proteins
T22185	40293-40295	,	denotes	,
T22186	40295-40297	DT	denotes	an
T22187	40332-40338	NN	denotes	factor
T22188	40298-40304	NN	denotes	orphan
T22189	40305-40313	NN	denotes	receptor
T22190	40314-40318	NN	denotes	germ
T22191	40319-40323	NN	denotes	cell
T22192	40318-40319	HYPH	denotes	-
T22193	40324-40331	JJ	denotes	nuclear
T22194	40338-40340	,	denotes	,
T22195	40340-40343	CC	denotes	and
T22196	40344-40357	NN	denotes	recombination
T22197	40358-40365	VBN	denotes	related
T22198	40357-40358	HYPH	denotes	-
T22199	40366-40374	NN	denotes	proteins
T22200	40375-40376	-LRB-	denotes	[
T22201	40376-40378	CD	denotes	60
T22202	40378-40379	-RRB-	denotes	]
T22203	40379-40380	.	denotes	.
T22204	40380-40486	sentence	denotes	A common feature of these proteins is involvement with heterochromatin and/or transcriptional repression.
T22205	40381-40382	DT	denotes	A
T22206	40390-40397	NN	denotes	feature
T22207	40383-40389	JJ	denotes	common
T22208	40416-40418	VBZ	denotes	is
T22209	40398-40400	IN	denotes	of
T22210	40401-40406	DT	denotes	these
T22211	40407-40415	NN	denotes	proteins
T22212	40419-40430	NN	denotes	involvement
T22213	40431-40435	IN	denotes	with
T22214	40436-40451	NN	denotes	heterochromatin
T22215	40475-40485	NN	denotes	repression
T22216	40452-40455	CC	denotes	and
T22217	40455-40456	HYPH	denotes	/
T22218	40456-40458	CC	denotes	or
T22219	40459-40474	JJ	denotes	transcriptional
T22220	40485-40486	.	denotes	.
T22221	40486-40595	sentence	denotes	DMRT7 is unusual among XY body proteins in being related to highly site-specific transcriptional regulators.
T22222	40487-40492	NN	denotes	DMRT7
T22223	40493-40495	VBZ	denotes	is
T22224	40496-40503	JJ	denotes	unusual
T22225	40504-40509	IN	denotes	among
T22226	40510-40512	NN	denotes	XY
T22227	40518-40526	NN	denotes	proteins
T22228	40513-40517	NN	denotes	body
T22229	40527-40529	IN	denotes	in
T22230	40530-40535	VBG	denotes	being
T22231	40536-40543	JJ	denotes	related
T22232	40544-40546	IN	denotes	to
T22233	40547-40553	RB	denotes	highly
T22234	40559-40567	JJ	denotes	specific
T22235	40554-40558	NN	denotes	site
T22236	40558-40559	HYPH	denotes	-
T22237	40584-40594	NNS	denotes	regulators
T22238	40568-40583	JJ	denotes	transcriptional
T22239	40594-40595	.	denotes	.
T22240	40595-40777	sentence	denotes	An attractive speculation is that DMRT7 may provide sequence specificity in recruiting other proteins, such as chromatin modifiers, to the XY body as part of the transition to PMSC.
T22241	40596-40598	DT	denotes	An
T22242	40610-40621	NN	denotes	speculation
T22243	40599-40609	JJ	denotes	attractive
T22244	40622-40624	VBZ	denotes	is
T22245	40625-40629	IN	denotes	that
T22246	40640-40647	VB	denotes	provide
T22247	40630-40635	NN	denotes	DMRT7
T22248	40636-40639	MD	denotes	may
T22249	40648-40656	NN	denotes	sequence
T22250	40657-40668	NN	denotes	specificity
T22251	40669-40671	IN	denotes	in
T22252	40672-40682	VBG	denotes	recruiting
T22253	40683-40688	JJ	denotes	other
T22254	40689-40697	NN	denotes	proteins
T22255	40697-40699	,	denotes	,
T22256	40699-40703	JJ	denotes	such
T22257	40704-40706	IN	denotes	as
T22258	40707-40716	NN	denotes	chromatin
T22259	40717-40726	NNS	denotes	modifiers
T22260	40726-40728	,	denotes	,
T22261	40728-40730	IN	denotes	to
T22262	40731-40734	DT	denotes	the
T22263	40738-40742	NN	denotes	body
T22264	40735-40737	NN	denotes	XY
T22265	40743-40745	IN	denotes	as
T22266	40746-40750	NN	denotes	part
T22267	40751-40753	IN	denotes	of
T22268	40754-40757	DT	denotes	the
T22269	40758-40768	NN	denotes	transition
T22270	40769-40771	IN	denotes	to
T22271	40772-40776	NN	denotes	PMSC
T22272	40776-40777	.	denotes	.
T22273	40777-41001	sentence	denotes	Chromatin regulation may be a common mechanism for DM domain proteins, as we find that other DM domain proteins associate with chromatin modifying complexes (M. W. Murphy, D. Zarkower, and V. J. Bardwell, unpublished data).
T22274	40778-40787	NN	denotes	Chromatin
T22275	40788-40798	NN	denotes	regulation
T22276	40803-40805	VB	denotes	be
T22277	40799-40802	MD	denotes	may
T22278	40806-40807	DT	denotes	a
T22279	40815-40824	NN	denotes	mechanism
T22280	40808-40814	JJ	denotes	common
T22281	40825-40828	IN	denotes	for
T22282	40829-40831	NN	denotes	DM
T22283	40839-40847	NN	denotes	proteins
T22284	40832-40838	NN	denotes	domain
T22285	40847-40849	,	denotes	,
T22286	40849-40851	IN	denotes	as
T22287	40855-40859	VBP	denotes	find
T22288	40852-40854	PRP	denotes	we
T22289	40860-40864	IN	denotes	that
T22290	40890-40899	VBP	denotes	associate
T22291	40865-40870	JJ	denotes	other
T22292	40881-40889	NN	denotes	proteins
T22293	40871-40873	NN	denotes	DM
T22294	40874-40880	NN	denotes	domain
T22295	40900-40904	IN	denotes	with
T22296	40905-40914	NN	denotes	chromatin
T22297	40915-40924	NN	denotes	modifying
T22298	40925-40934	NNS	denotes	complexes
T22299	40935-40936	-LRB-	denotes	(
T22300	40936-40938	NNP	denotes	M.
T22301	40939-40941	NNP	denotes	W.
T22302	40942-40948	NNP	denotes	Murphy
T22303	40948-40950	,	denotes	,
T22304	40950-40952	NNP	denotes	D.
T22305	40953-40961	NNP	denotes	Zarkower
T22306	40961-40963	,	denotes	,
T22307	40963-40966	CC	denotes	and
T22308	40967-40969	NNP	denotes	V.
T22309	40970-40972	NNP	denotes	J.
T22310	40973-40981	NNP	denotes	Bardwell
T22311	40981-40983	,	denotes	,
T22312	40983-40994	JJ	denotes	unpublished
T22313	40995-40999	NNS	denotes	data
T22314	40999-41000	-RRB-	denotes	)
T22315	41000-41001	.	denotes	.
T22316	41001-41108	sentence	denotes	The finding that Dmrt7 is essential for mammalian meiosis expands the known functions of this gene family.
T22317	41002-41005	DT	denotes	The
T22318	41006-41013	NN	denotes	finding
T22319	41060-41067	VBZ	denotes	expands
T22320	41014-41018	IN	denotes	that
T22321	41025-41027	VBZ	denotes	is
T22322	41019-41024	NN	denotes	Dmrt7
T22323	41028-41037	JJ	denotes	essential
T22324	41038-41041	IN	denotes	for
T22325	41042-41051	JJ	denotes	mammalian
T22326	41052-41059	NN	denotes	meiosis
T22327	41068-41071	DT	denotes	the
T22328	41078-41087	NNS	denotes	functions
T22329	41072-41077	VBN	denotes	known
T22330	41088-41090	IN	denotes	of
T22331	41091-41095	DT	denotes	this
T22332	41101-41107	NN	denotes	family
T22333	41096-41100	NN	denotes	gene
T22334	41107-41108	.	denotes	.
T22335	41108-41195	sentence	denotes	Invertebrate DM domain genes so far have only been found to function in somatic cells.
T22336	41109-41121	NN	denotes	Invertebrate
T22337	41132-41137	NNS	denotes	genes
T22338	41122-41124	NN	denotes	DM
T22339	41125-41131	NN	denotes	domain
T22340	41160-41165	VBN	denotes	found
T22341	41138-41140	RB	denotes	so
T22342	41141-41144	RB	denotes	far
T22343	41145-41149	VBP	denotes	have
T22344	41150-41154	RB	denotes	only
T22345	41155-41159	VBN	denotes	been
T22346	41166-41168	TO	denotes	to
T22347	41169-41177	VB	denotes	function
T22348	41178-41180	IN	denotes	in
T22349	41181-41188	JJ	denotes	somatic
T22350	41189-41194	NNS	denotes	cells
T22351	41194-41195	.	denotes	.
T22352	41195-41285	sentence	denotes	Two other DM domain genes, Dmrt1 and Dmrt4, do affect germ cell development in the mouse.
T22353	41196-41199	CD	denotes	Two
T22354	41216-41221	NNS	denotes	genes
T22355	41200-41205	JJ	denotes	other
T22356	41206-41208	NN	denotes	DM
T22357	41209-41215	NN	denotes	domain
T22358	41243-41249	VB	denotes	affect
T22359	41221-41223	,	denotes	,
T22360	41223-41228	NN	denotes	Dmrt1
T22361	41229-41232	CC	denotes	and
T22362	41233-41238	NN	denotes	Dmrt4
T22363	41238-41240	,	denotes	,
T22364	41240-41242	VBP	denotes	do
T22365	41250-41254	NN	denotes	germ
T22366	41255-41259	NN	denotes	cell
T22367	41260-41271	NN	denotes	development
T22368	41272-41274	IN	denotes	in
T22369	41275-41278	DT	denotes	the
T22370	41279-41284	NN	denotes	mouse
T22371	41284-41285	.	denotes	.
T22372	41285-41506	sentence	denotes	Dmrt1 is required in pre-meiotic male germ cells for differentiation of gonocytes into spermatogonia, as well as in Sertoli cells, but it is not expressed in meiotic cells [31] (S. Kim and D. Zarkower, unpublished data).
T22373	41286-41291	NN	denotes	Dmrt1
T22374	41295-41303	VBN	denotes	required
T22375	41292-41294	VBZ	denotes	is
T22376	41304-41306	IN	denotes	in
T22377	41307-41318	JJ	denotes	pre-meiotic
T22378	41329-41334	NNS	denotes	cells
T22379	41319-41323	JJ	denotes	male
T22380	41324-41328	NN	denotes	germ
T22381	41335-41338	IN	denotes	for
T22382	41339-41354	NN	denotes	differentiation
T22383	41355-41357	IN	denotes	of
T22384	41358-41367	NNS	denotes	gonocytes
T22385	41368-41372	IN	denotes	into
T22386	41373-41386	NNS	denotes	spermatogonia
T22387	41386-41388	,	denotes	,
T22388	41388-41390	RB	denotes	as
T22389	41396-41398	IN	denotes	as
T22390	41391-41395	RB	denotes	well
T22391	41399-41401	IN	denotes	in
T22392	41402-41409	NNP	denotes	Sertoli
T22393	41410-41415	NNS	denotes	cells
T22394	41415-41417	,	denotes	,
T22395	41417-41420	CC	denotes	but
T22396	41421-41423	PRP	denotes	it
T22397	41431-41440	VBN	denotes	expressed
T22398	41424-41426	VBZ	denotes	is
T22399	41427-41430	RB	denotes	not
T22400	41441-41443	IN	denotes	in
T22401	41444-41451	JJ	denotes	meiotic
T22402	41452-41457	NNS	denotes	cells
T22403	41458-41459	-LRB-	denotes	[
T22404	41459-41461	CD	denotes	31
T22405	41461-41462	-RRB-	denotes	]
T22406	41463-41464	-LRB-	denotes	(
T22407	41464-41466	NNP	denotes	S.
T22408	41467-41470	NNP	denotes	Kim
T22409	41471-41474	CC	denotes	and
T22410	41475-41477	NNP	denotes	D.
T22411	41478-41486	NNP	denotes	Zarkower
T22412	41486-41488	,	denotes	,
T22413	41488-41499	JJ	denotes	unpublished
T22414	41500-41504	NNS	denotes	data
T22415	41504-41505	-RRB-	denotes	)
T22416	41505-41506	.	denotes	.
T22417	41506-41690	sentence	denotes	The requirement for DMRT1 in pre-meiotic germ cells and DMRT7 in meiotic germ cells demonstrates that DM domain proteins act at multiple critical points of male germ cell development.
T22418	41507-41510	DT	denotes	The
T22419	41511-41522	NN	denotes	requirement
T22420	41591-41603	VBZ	denotes	demonstrates
T22421	41523-41526	IN	denotes	for
T22422	41527-41532	NN	denotes	DMRT1
T22423	41533-41535	IN	denotes	in
T22424	41536-41547	JJ	denotes	pre-meiotic
T22425	41553-41558	NNS	denotes	cells
T22426	41548-41552	NN	denotes	germ
T22427	41559-41562	CC	denotes	and
T22428	41563-41568	NN	denotes	DMRT7
T22429	41569-41571	IN	denotes	in
T22430	41572-41579	JJ	denotes	meiotic
T22431	41585-41590	NNS	denotes	cells
T22432	41580-41584	NN	denotes	germ
T22433	41604-41608	IN	denotes	that
T22434	41628-41631	VBP	denotes	act
T22435	41609-41611	NN	denotes	DM
T22436	41612-41618	NN	denotes	domain
T22437	41619-41627	NN	denotes	proteins
T22438	41632-41634	IN	denotes	at
T22439	41635-41643	JJ	denotes	multiple
T22440	41653-41659	NNS	denotes	points
T22441	41644-41652	JJ	denotes	critical
T22442	41660-41662	IN	denotes	of
T22443	41663-41667	JJ	denotes	male
T22444	41678-41689	NN	denotes	development
T22445	41668-41672	NN	denotes	germ
T22446	41673-41677	NN	denotes	cell
T22447	41689-41690	.	denotes	.
T22448	41690-41868	sentence	denotes	Ovaries of Dmrt4 mutant females have polyovular follicles (follicles containing multiple oocytes), but it is unknown whether this reflects a defect in the germ line or the soma.
T22449	41691-41698	NNS	denotes	Ovaries
T22450	41723-41727	VBP	denotes	have
T22451	41699-41701	IN	denotes	of
T22452	41702-41707	NN	denotes	Dmrt4
T22453	41715-41722	NNS	denotes	females
T22454	41708-41714	NN	denotes	mutant
T22455	41728-41738	JJ	denotes	polyovular
T22456	41739-41748	NNS	denotes	follicles
T22457	41749-41750	-LRB-	denotes	(
T22458	41750-41759	NNS	denotes	follicles
T22459	41760-41770	VBG	denotes	containing
T22460	41771-41779	JJ	denotes	multiple
T22461	41780-41787	NNS	denotes	oocytes
T22462	41787-41788	-RRB-	denotes	)
T22463	41788-41790	,	denotes	,
T22464	41790-41793	CC	denotes	but
T22465	41794-41796	PRP	denotes	it
T22466	41797-41799	VBZ	denotes	is
T22467	41800-41807	JJ	denotes	unknown
T22468	41808-41815	IN	denotes	whether
T22469	41821-41829	VBZ	denotes	reflects
T22470	41816-41820	DT	denotes	this
T22471	41830-41831	DT	denotes	a
T22472	41832-41838	NN	denotes	defect
T22473	41839-41841	IN	denotes	in
T22474	41842-41845	DT	denotes	the
T22475	41851-41855	NN	denotes	line
T22476	41846-41850	NN	denotes	germ
T22477	41856-41858	CC	denotes	or
T22478	41859-41862	DT	denotes	the
T22479	41863-41867	NN	denotes	soma
T22480	41867-41868	.	denotes	.
T22481	41868-42078	sentence	denotes	It is notable that at least three mammalian DM domain genes affect gonadal development only in one sex, given the similar roles of related proteins in directing sex-specific somatic development in other phyla.
T22482	41869-41871	PRP	denotes	It
T22483	41872-41874	VBZ	denotes	is
T22484	41875-41882	JJ	denotes	notable
T22485	41883-41887	IN	denotes	that
T22486	41929-41935	VBP	denotes	affect
T22487	41888-41890	RB	denotes	at
T22488	41897-41902	CD	denotes	three
T22489	41891-41896	RBS	denotes	least
T22490	41923-41928	NNS	denotes	genes
T22491	41903-41912	JJ	denotes	mammalian
T22492	41913-41915	NN	denotes	DM
T22493	41916-41922	NN	denotes	domain
T22494	41936-41943	JJ	denotes	gonadal
T22495	41944-41955	NN	denotes	development
T22496	41956-41960	RB	denotes	only
T22497	41961-41963	IN	denotes	in
T22498	41964-41967	CD	denotes	one
T22499	41968-41971	NN	denotes	sex
T22500	41971-41973	,	denotes	,
T22501	41973-41978	VBN	denotes	given
T22502	41979-41982	DT	denotes	the
T22503	41991-41996	NNS	denotes	roles
T22504	41983-41990	JJ	denotes	similar
T22505	41997-41999	IN	denotes	of
T22506	42000-42007	JJ	denotes	related
T22507	42008-42016	NN	denotes	proteins
T22508	42017-42019	IN	denotes	in
T22509	42020-42029	VBG	denotes	directing
T22510	42030-42033	NN	denotes	sex
T22511	42034-42042	JJ	denotes	specific
T22512	42033-42034	HYPH	denotes	-
T22513	42051-42062	NN	denotes	development
T22514	42043-42050	JJ	denotes	somatic
T22515	42063-42065	IN	denotes	in
T22516	42066-42071	JJ	denotes	other
T22517	42072-42077	NNS	denotes	phyla
T22518	42077-42078	.	denotes	.
T22519	42078-42252	sentence	denotes	Strikingly, Dmrt7 is present, not only in placental mammals, but also in marsupials and a monotreme (egg-laying mammal), the platypus, which has a clear Dmrt7 ortholog [36].
T22520	42079-42089	RB	denotes	Strikingly
T22521	42097-42099	VBZ	denotes	is
T22522	42089-42091	,	denotes	,
T22523	42091-42096	NN	denotes	Dmrt7
T22524	42100-42107	JJ	denotes	present
T22525	42107-42109	,	denotes	,
T22526	42109-42112	RB	denotes	not
T22527	42118-42120	IN	denotes	in
T22528	42113-42117	RB	denotes	only
T22529	42121-42130	JJ	denotes	placental
T22530	42131-42138	NNS	denotes	mammals
T22531	42138-42140	,	denotes	,
T22532	42140-42143	CC	denotes	but
T22533	42144-42148	RB	denotes	also
T22534	42149-42151	IN	denotes	in
T22535	42152-42162	NNS	denotes	marsupials
T22536	42163-42166	CC	denotes	and
T22537	42167-42168	DT	denotes	a
T22538	42169-42178	NN	denotes	monotreme
T22539	42179-42180	-LRB-	denotes	(
T22540	42191-42197	NN	denotes	mammal
T22541	42180-42183	NN	denotes	egg
T22542	42183-42184	HYPH	denotes	-
T22543	42184-42190	VBG	denotes	laying
T22544	42197-42198	-RRB-	denotes	)
T22545	42198-42200	,	denotes	,
T22546	42200-42203	DT	denotes	the
T22547	42204-42212	NN	denotes	platypus
T22548	42212-42214	,	denotes	,
T22549	42214-42219	WDT	denotes	which
T22550	42220-42223	VBZ	denotes	has
T22551	42224-42225	DT	denotes	a
T22552	42238-42246	NN	denotes	ortholog
T22553	42226-42231	JJ	denotes	clear
T22554	42232-42237	NN	denotes	Dmrt7
T22555	42247-42248	-LRB-	denotes	[
T22556	42248-42250	CD	denotes	36
T22557	42250-42251	-RRB-	denotes	]
T22558	42251-42252	.	denotes	.
T22559	42252-42378	sentence	denotes	However, no close Dmrt7 ortholog has been reported in nonmammalian vertebrates, and our database searches did not reveal one.
T22560	42253-42260	RB	denotes	However
T22561	42295-42303	VBN	denotes	reported
T22562	42260-42262	,	denotes	,
T22563	42262-42264	DT	denotes	no
T22564	42277-42285	NN	denotes	ortholog
T22565	42265-42270	JJ	denotes	close
T22566	42271-42276	NN	denotes	Dmrt7
T22567	42286-42289	VBZ	denotes	has
T22568	42290-42294	VBN	denotes	been
T22569	42304-42306	IN	denotes	in
T22570	42307-42319	JJ	denotes	nonmammalian
T22571	42320-42331	NNS	denotes	vertebrates
T22572	42331-42333	,	denotes	,
T22573	42333-42336	CC	denotes	and
T22574	42337-42340	PRP$	denotes	our
T22575	42350-42358	NNS	denotes	searches
T22576	42341-42349	NN	denotes	database
T22577	42367-42373	VB	denotes	reveal
T22578	42359-42362	VBD	denotes	did
T22579	42363-42366	RB	denotes	not
T22580	42374-42377	CD	denotes	one
T22581	42377-42378	.	denotes	.
T22582	42378-42526	sentence	denotes	Thus, Dmrt7 likely arose, presumably by duplication and divergence of another Dmrt gene, shortly before or coincident with the mammalian radiation.
T22583	42379-42383	RB	denotes	Thus
T22584	42398-42403	VBD	denotes	arose
T22585	42383-42385	,	denotes	,
T22586	42385-42390	NN	denotes	Dmrt7
T22587	42391-42397	RB	denotes	likely
T22588	42403-42405	,	denotes	,
T22589	42405-42415	RB	denotes	presumably
T22590	42416-42418	IN	denotes	by
T22591	42419-42430	NN	denotes	duplication
T22592	42431-42434	CC	denotes	and
T22593	42435-42445	NN	denotes	divergence
T22594	42446-42448	IN	denotes	of
T22595	42449-42456	DT	denotes	another
T22596	42462-42466	NN	denotes	gene
T22597	42457-42461	NN	denotes	Dmrt
T22598	42466-42468	,	denotes	,
T22599	42468-42475	RB	denotes	shortly
T22600	42476-42482	IN	denotes	before
T22601	42483-42485	CC	denotes	or
T22602	42486-42496	JJ	denotes	coincident
T22603	42516-42525	NN	denotes	radiation
T22604	42497-42501	IN	denotes	with
T22605	42502-42505	DT	denotes	the
T22606	42506-42515	JJ	denotes	mammalian
T22607	42525-42526	.	denotes	.
T22608	42526-42696	sentence	denotes	Monotremes have five X and five Y chromosomes, which form an extended pairing chain during meiosis and appear unrelated to the sex chromosomes of the other mammals [61].
T22609	42527-42537	NNS	denotes	Monotremes
T22610	42538-42542	VBP	denotes	have
T22611	42543-42547	CD	denotes	five
T22612	42548-42549	NN	denotes	X
T22613	42550-42553	CC	denotes	and
T22614	42554-42558	CD	denotes	five
T22615	42559-42560	NN	denotes	Y
T22616	42561-42572	NNS	denotes	chromosomes
T22617	42572-42574	,	denotes	,
T22618	42574-42579	WDT	denotes	which
T22619	42580-42584	VBP	denotes	form
T22620	42585-42587	DT	denotes	an
T22621	42605-42610	NN	denotes	chain
T22622	42588-42596	VBN	denotes	extended
T22623	42597-42604	NN	denotes	pairing
T22624	42611-42617	IN	denotes	during
T22625	42618-42625	NN	denotes	meiosis
T22626	42626-42629	CC	denotes	and
T22627	42630-42636	VBP	denotes	appear
T22628	42637-42646	JJ	denotes	unrelated
T22629	42647-42649	IN	denotes	to
T22630	42650-42653	DT	denotes	the
T22631	42658-42669	NNS	denotes	chromosomes
T22632	42654-42657	NN	denotes	sex
T22633	42670-42672	IN	denotes	of
T22634	42673-42676	DT	denotes	the
T22635	42683-42690	NNS	denotes	mammals
T22636	42677-42682	JJ	denotes	other
T22637	42691-42692	-LRB-	denotes	[
T22638	42692-42694	CD	denotes	61
T22639	42694-42695	-RRB-	denotes	]
T22640	42695-42696	.	denotes	.
T22641	42696-42848	sentence	denotes	The presence of Dmrt7 in both lineages may support a common origin for either the sex chromosomes or the sex chromatin of monotremes and other mammals.
T22642	42697-42700	DT	denotes	The
T22643	42701-42709	NN	denotes	presence
T22644	42740-42747	VB	denotes	support
T22645	42710-42712	IN	denotes	of
T22646	42713-42718	NN	denotes	Dmrt7
T22647	42719-42721	IN	denotes	in
T22648	42722-42726	DT	denotes	both
T22649	42727-42735	NNS	denotes	lineages
T22650	42736-42739	MD	denotes	may
T22651	42748-42749	DT	denotes	a
T22652	42757-42763	NN	denotes	origin
T22653	42750-42756	JJ	denotes	common
T22654	42764-42767	IN	denotes	for
T22655	42768-42774	CC	denotes	either
T22656	42783-42794	NNS	denotes	chromosomes
T22657	42775-42778	DT	denotes	the
T22658	42779-42782	NN	denotes	sex
T22659	42795-42797	CC	denotes	or
T22660	42798-42801	DT	denotes	the
T22661	42806-42815	NN	denotes	chromatin
T22662	42802-42805	NN	denotes	sex
T22663	42816-42818	IN	denotes	of
T22664	42819-42829	NNS	denotes	monotremes
T22665	42830-42833	CC	denotes	and
T22666	42834-42839	JJ	denotes	other
T22667	42840-42847	NNS	denotes	mammals
T22668	42847-42848	.	denotes	.
T22669	42848-43101	sentence	denotes	A plausible model is that Dmrt7 evolved during the establishment of mammalian sex determination to help cope with ancestral differences in gene dosage, chromosome pairing, recombination, or other meiotic issues arising from sex chromosome heteromorphy.
T22670	42849-42850	DT	denotes	A
T22671	42861-42866	NN	denotes	model
T22672	42851-42860	JJ	denotes	plausible
T22673	42867-42869	VBZ	denotes	is
T22674	42870-42874	IN	denotes	that
T22675	42881-42888	VBD	denotes	evolved
T22676	42875-42880	NN	denotes	Dmrt7
T22677	42889-42895	IN	denotes	during
T22678	42896-42899	DT	denotes	the
T22679	42900-42913	NN	denotes	establishment
T22680	42914-42916	IN	denotes	of
T22681	42917-42926	JJ	denotes	mammalian
T22682	42931-42944	NN	denotes	determination
T22683	42927-42930	NN	denotes	sex
T22684	42945-42947	TO	denotes	to
T22685	42953-42957	VB	denotes	cope
T22686	42948-42952	VB	denotes	help
T22687	42958-42962	IN	denotes	with
T22688	42963-42972	JJ	denotes	ancestral
T22689	42973-42984	NNS	denotes	differences
T22690	42985-42987	IN	denotes	in
T22691	42988-42992	NN	denotes	gene
T22692	42993-42999	NN	denotes	dosage
T22693	42999-43001	,	denotes	,
T22694	43001-43011	NN	denotes	chromosome
T22695	43012-43019	NN	denotes	pairing
T22696	43019-43021	,	denotes	,
T22697	43021-43034	NN	denotes	recombination
T22698	43034-43036	,	denotes	,
T22699	43036-43038	CC	denotes	or
T22700	43039-43044	JJ	denotes	other
T22701	43053-43059	NNS	denotes	issues
T22702	43045-43052	JJ	denotes	meiotic
T22703	43060-43067	VBG	denotes	arising
T22704	43068-43072	IN	denotes	from
T22705	43073-43076	NN	denotes	sex
T22706	43077-43087	NN	denotes	chromosome
T22707	43088-43100	NN	denotes	heteromorphy
T22708	43100-43101	.	denotes	.
T22709	43101-43383	sentence	denotes	In this regard, we speculate that the recruitment of Dmrt7 during mammalian evolution may be analogous to the recruitment of chromatin regulatory complexes to achieve somatic dosage compensation during evolution of heteromorphic sex chromosomes in several phyla (reviewed in [62]).
T22710	43102-43104	IN	denotes	In
T22711	43121-43130	VBP	denotes	speculate
T22712	43105-43109	DT	denotes	this
T22713	43110-43116	NN	denotes	regard
T22714	43116-43118	,	denotes	,
T22715	43118-43120	PRP	denotes	we
T22716	43131-43135	IN	denotes	that
T22717	43192-43194	VB	denotes	be
T22718	43136-43139	DT	denotes	the
T22719	43140-43151	NN	denotes	recruitment
T22720	43152-43154	IN	denotes	of
T22721	43155-43160	NN	denotes	Dmrt7
T22722	43161-43167	IN	denotes	during
T22723	43168-43177	JJ	denotes	mammalian
T22724	43178-43187	NN	denotes	evolution
T22725	43188-43191	MD	denotes	may
T22726	43195-43204	JJ	denotes	analogous
T22727	43205-43207	IN	denotes	to
T22728	43208-43211	DT	denotes	the
T22729	43212-43223	NN	denotes	recruitment
T22730	43224-43226	IN	denotes	of
T22731	43227-43236	NN	denotes	chromatin
T22732	43248-43257	NNS	denotes	complexes
T22733	43237-43247	JJ	denotes	regulatory
T22734	43258-43260	TO	denotes	to
T22735	43261-43268	VB	denotes	achieve
T22736	43269-43276	JJ	denotes	somatic
T22737	43284-43296	NN	denotes	compensation
T22738	43277-43283	NN	denotes	dosage
T22739	43297-43303	IN	denotes	during
T22740	43304-43313	NN	denotes	evolution
T22741	43314-43316	IN	denotes	of
T22742	43317-43330	JJ	denotes	heteromorphic
T22743	43335-43346	NNS	denotes	chromosomes
T22744	43331-43334	NN	denotes	sex
T22745	43347-43349	IN	denotes	in
T22746	43350-43357	JJ	denotes	several
T22747	43358-43363	NNS	denotes	phyla
T22748	43364-43365	-LRB-	denotes	(
T22749	43365-43373	VBN	denotes	reviewed
T22750	43374-43376	IN	denotes	in
T22751	43377-43378	-LRB-	denotes	[
T22752	43378-43380	CD	denotes	62
T22753	43380-43381	-RRB-	denotes	]
T22754	43381-43382	-RRB-	denotes	)
T22755	43382-43383	.	denotes	.
T22756	43383-43488	sentence	denotes	It will be of interest to determine whether DMRT7 localizes to sex chromosomes during monotreme meiosis.
T22757	43384-43386	PRP	denotes	It
T22758	43392-43394	VB	denotes	be
T22759	43387-43391	MD	denotes	will
T22760	43395-43397	IN	denotes	of
T22761	43398-43406	NN	denotes	interest
T22762	43407-43409	TO	denotes	to
T22763	43410-43419	VB	denotes	determine
T22764	43420-43427	IN	denotes	whether
T22765	43434-43443	VBZ	denotes	localizes
T22766	43428-43433	NN	denotes	DMRT7
T22767	43444-43446	IN	denotes	to
T22768	43447-43450	NN	denotes	sex
T22769	43451-43462	NNS	denotes	chromosomes
T22770	43463-43469	IN	denotes	during
T22771	43470-43479	NN	denotes	monotreme
T22772	43480-43487	NN	denotes	meiosis
T22773	43487-43488	.	denotes	.
T22774	43488-43619	sentence	denotes	In summary, we have found that the mammal-specific DM domain protein DMRT7 is essential for meiotic prophase progression in males.
T22775	43489-43491	IN	denotes	In
T22776	43509-43514	VBN	denotes	found
T22777	43492-43499	NN	denotes	summary
T22778	43499-43501	,	denotes	,
T22779	43501-43503	PRP	denotes	we
T22780	43504-43508	VBP	denotes	have
T22781	43515-43519	IN	denotes	that
T22782	43564-43566	VBZ	denotes	is
T22783	43520-43523	DT	denotes	the
T22784	43558-43563	NN	denotes	DMRT7
T22785	43524-43530	NN	denotes	mammal
T22786	43531-43539	JJ	denotes	specific
T22787	43530-43531	HYPH	denotes	-
T22788	43540-43542	NN	denotes	DM
T22789	43543-43549	NN	denotes	domain
T22790	43550-43557	NN	denotes	protein
T22791	43567-43576	JJ	denotes	essential
T22792	43577-43580	IN	denotes	for
T22793	43581-43588	JJ	denotes	meiotic
T22794	43589-43597	NN	denotes	prophase
T22795	43598-43609	NN	denotes	progression
T22796	43610-43612	IN	denotes	in
T22797	43613-43618	NNS	denotes	males
T22798	43618-43619	.	denotes	.
T22799	43619-43843	sentence	denotes	DMRT7 localizes to the sex chromosomes after they are assembled into specialized heterochromatin, and many Dmrt7 mutant cells have epigenetic defects in the modification of the sex chromatin between pachytene and diplotene.
T22800	43620-43625	NN	denotes	DMRT7
T22801	43626-43635	VBZ	denotes	localizes
T22802	43636-43638	IN	denotes	to
T22803	43639-43642	DT	denotes	the
T22804	43647-43658	NNS	denotes	chromosomes
T22805	43643-43646	NN	denotes	sex
T22806	43659-43664	IN	denotes	after
T22807	43674-43683	VBN	denotes	assembled
T22808	43665-43669	PRP	denotes	they
T22809	43670-43673	VBP	denotes	are
T22810	43684-43688	IN	denotes	into
T22811	43689-43700	JJ	denotes	specialized
T22812	43701-43716	NN	denotes	heterochromatin
T22813	43716-43718	,	denotes	,
T22814	43718-43721	CC	denotes	and
T22815	43722-43726	JJ	denotes	many
T22816	43740-43745	NNS	denotes	cells
T22817	43727-43732	NN	denotes	Dmrt7
T22818	43733-43739	NN	denotes	mutant
T22819	43746-43750	VBP	denotes	have
T22820	43751-43761	JJ	denotes	epigenetic
T22821	43762-43769	NNS	denotes	defects
T22822	43770-43772	IN	denotes	in
T22823	43773-43776	DT	denotes	the
T22824	43777-43789	NN	denotes	modification
T22825	43790-43792	IN	denotes	of
T22826	43793-43796	DT	denotes	the
T22827	43801-43810	NN	denotes	chromatin
T22828	43797-43800	NN	denotes	sex
T22829	43811-43818	IN	denotes	between
T22830	43819-43828	NN	denotes	pachytene
T22831	43829-43832	CC	denotes	and
T22832	43833-43842	NN	denotes	diplotene
T22833	43842-43843	.	denotes	.
T22834	43843-44043	sentence	denotes	Although Dmrt7 belongs to an ancient and conserved gene family, it is found only in mammals, and to our knowledge DMRT7 is the only example of a mammal-specific protein that is essential for meiosis.
T22835	43844-43852	IN	denotes	Although
T22836	43859-43866	VBZ	denotes	belongs
T22837	43853-43858	NN	denotes	Dmrt7
T22838	43914-43919	VBN	denotes	found
T22839	43867-43869	IN	denotes	to
T22840	43870-43872	DT	denotes	an
T22841	43900-43906	NN	denotes	family
T22842	43873-43880	JJ	denotes	ancient
T22843	43881-43884	CC	denotes	and
T22844	43885-43894	VBN	denotes	conserved
T22845	43895-43899	NN	denotes	gene
T22846	43906-43908	,	denotes	,
T22847	43908-43910	PRP	denotes	it
T22848	43911-43913	VBZ	denotes	is
T22849	43920-43924	RB	denotes	only
T22850	43925-43927	IN	denotes	in
T22851	43928-43935	NNS	denotes	mammals
T22852	43935-43937	,	denotes	,
T22853	43937-43940	CC	denotes	and
T22854	43941-43943	IN	denotes	to
T22855	43964-43966	VBZ	denotes	is
T22856	43944-43947	PRP$	denotes	our
T22857	43948-43957	NN	denotes	knowledge
T22858	43958-43963	NN	denotes	DMRT7
T22859	43967-43970	DT	denotes	the
T22860	43976-43983	NN	denotes	example
T22861	43971-43975	JJ	denotes	only
T22862	43984-43986	IN	denotes	of
T22863	43987-43988	DT	denotes	a
T22864	44005-44012	NN	denotes	protein
T22865	43989-43995	NN	denotes	mammal
T22866	43996-44004	JJ	denotes	specific
T22867	43995-43996	HYPH	denotes	-
T22868	44013-44017	WDT	denotes	that
T22869	44018-44020	VBZ	denotes	is
T22870	44021-44030	JJ	denotes	essential
T22871	44031-44034	IN	denotes	for
T22872	44035-44042	NN	denotes	meiosis
T22873	44042-44043	.	denotes	.
T22874	44043-44168	sentence	denotes	It will be important to determine the precise mechanism by which DMRT7 affects sex chromatin regulation during male meiosis.
T22875	44044-44046	PRP	denotes	It
T22876	44052-44054	VB	denotes	be
T22877	44047-44051	MD	denotes	will
T22878	44055-44064	JJ	denotes	important
T22879	44065-44067	TO	denotes	to
T22880	44068-44077	VB	denotes	determine
T22881	44078-44081	DT	denotes	the
T22882	44090-44099	NN	denotes	mechanism
T22883	44082-44089	JJ	denotes	precise
T22884	44100-44102	IN	denotes	by
T22885	44115-44122	VBZ	denotes	affects
T22886	44103-44108	WDT	denotes	which
T22887	44109-44114	NN	denotes	DMRT7
T22888	44123-44126	NN	denotes	sex
T22889	44137-44147	NN	denotes	regulation
T22890	44127-44136	NN	denotes	chromatin
T22891	44148-44154	IN	denotes	during
T22892	44155-44159	JJ	denotes	male
T22893	44160-44167	NN	denotes	meiosis
T22894	44167-44168	.	denotes	.
T23872	44634-44635	.	denotes	.
T23873	44635-44801	sentence	denotes	3′ to Pgk-neo and the loxP site, we inserted, as a XmaI/XmaI DNA fragment, the third intron of Dmrt7 (from 366 bp to 2,773 bp downstream of exon 3) generated by PCR.
T23874	44636-44637	CD	denotes	3
T23875	44672-44680	VBD	denotes	inserted
T23791	44193-44203	NN	denotes	Generation
T23792	44204-44206	IN	denotes	of
T23793	44207-44212	NN	denotes	Dmrt7
T23794	44213-44217	NNS	denotes	mice
T23795	44217-44218	.	denotes	.
T23796	44218-44486	sentence	denotes	A mouse Dmrt7 cDNA fragment containing sequences from exon 8 was used to screen a mouse BAC library from the 129/SvJ strain (Stratagene, http://www.stratagene.com), and clones containing promoter sequences were isolated and sequenced to obtain Dmrt7 genomic sequence.
T23797	44219-44220	DT	denotes	A
T23798	44238-44246	NN	denotes	fragment
T23799	44221-44226	NN	denotes	mouse
T23800	44227-44232	NN	denotes	Dmrt7
T23801	44233-44237	NN	denotes	cDNA
T23802	44284-44288	VBN	denotes	used
T23803	44247-44257	VBG	denotes	containing
T23804	44258-44267	NNS	denotes	sequences
T23805	44268-44272	IN	denotes	from
T23806	44273-44277	NN	denotes	exon
T23807	44278-44279	CD	denotes	8
T23808	44280-44283	VBD	denotes	was
T23809	44289-44291	TO	denotes	to
T23810	44292-44298	VB	denotes	screen
T23811	44299-44300	DT	denotes	a
T23812	44311-44318	NN	denotes	library
T23813	44301-44306	NN	denotes	mouse
T23814	44307-44310	NN	denotes	BAC
T23815	44319-44323	IN	denotes	from
T23816	44324-44327	DT	denotes	the
T23817	44336-44342	NN	denotes	strain
T23818	44328-44331	CD	denotes	129
T23819	44332-44335	NN	denotes	SvJ
T23820	44331-44332	HYPH	denotes	/
T23821	44343-44344	-LRB-	denotes	(
T23822	44344-44354	NN	denotes	Stratagene
T23823	44354-44356	,	denotes	,
T23824	44356-44381	NN	denotes	http://www.stratagene.com
T23825	44381-44382	-RRB-	denotes	)
T23826	44382-44384	,	denotes	,
T23827	44384-44387	CC	denotes	and
T23828	44388-44394	NNS	denotes	clones
T23829	44430-44438	VBN	denotes	isolated
T23830	44395-44405	VBG	denotes	containing
T23831	44406-44414	NN	denotes	promoter
T23832	44415-44424	NNS	denotes	sequences
T23833	44425-44429	VBD	denotes	were
T23834	44439-44442	CC	denotes	and
T23835	44443-44452	VBN	denotes	sequenced
T23836	44453-44455	TO	denotes	to
T23837	44456-44462	VB	denotes	obtain
T23838	44463-44468	NN	denotes	Dmrt7
T23839	44477-44485	NN	denotes	sequence
T23840	44469-44476	JJ	denotes	genomic
T23841	44485-44486	.	denotes	.
T23842	44486-44635	sentence	denotes	The targeting vector pDZ169 (diagrammed in Figure S2) was constructed by the following scheme: The vector pDZ157 was used as a backbone vector [31].
T23843	44487-44490	DT	denotes	The
T23844	44501-44507	NN	denotes	vector
T23845	44491-44500	NN	denotes	targeting
T23846	44545-44556	VBN	denotes	constructed
T23847	44508-44514	NN	denotes	pDZ169
T23848	44515-44516	-LRB-	denotes	(
T23849	44516-44526	VBN	denotes	diagrammed
T23850	44527-44529	IN	denotes	in
T23851	44530-44536	NN	denotes	Figure
T23852	44537-44539	NN	denotes	S2
T23853	44539-44540	-RRB-	denotes	)
T23854	44541-44544	VBD	denotes	was
T23855	44604-44608	VBN	denotes	used
T23856	44557-44559	IN	denotes	by
T23857	44560-44563	DT	denotes	the
T23858	44574-44580	NN	denotes	scheme
T23859	44564-44573	VBG	denotes	following
T23860	44580-44582	:	denotes	:
T23861	44582-44585	DT	denotes	The
T23862	44593-44599	NN	denotes	pDZ157
T23863	44586-44592	NN	denotes	vector
T23864	44600-44603	VBD	denotes	was
T23865	44609-44611	IN	denotes	as
T23866	44612-44613	DT	denotes	a
T23867	44623-44629	NN	denotes	vector
T23868	44614-44622	NN	denotes	backbone
T23869	44630-44631	-LRB-	denotes	[
T23870	44631-44633	CD	denotes	31
T23871	44633-44634	-RRB-	denotes	]
T23876	44637-44638	SYM	denotes	′
T23877	44639-44641	IN	denotes	to
T23878	44642-44645	NN	denotes	Pgk
T23879	44646-44649	NN	denotes	neo
T23880	44645-44646	HYPH	denotes	-
T23881	44650-44653	CC	denotes	and
T23882	44654-44657	DT	denotes	the
T23883	44663-44667	NN	denotes	site
T23884	44658-44662	NN	denotes	loxP
T23885	44667-44669	,	denotes	,
T23886	44669-44671	PRP	denotes	we
T23887	44680-44682	,	denotes	,
T23888	44682-44684	IN	denotes	as
T23889	44685-44686	DT	denotes	a
T23890	44701-44709	NN	denotes	fragment
T23891	44687-44691	NN	denotes	XmaI
T23892	44692-44696	NN	denotes	XmaI
T23893	44691-44692	HYPH	denotes	/
T23894	44697-44700	NN	denotes	DNA
T23895	44709-44711	,	denotes	,
T23896	44711-44714	DT	denotes	the
T23897	44721-44727	NN	denotes	intron
T23898	44715-44720	JJ	denotes	third
T23899	44728-44730	IN	denotes	of
T23900	44731-44736	NN	denotes	Dmrt7
T23901	44737-44738	-LRB-	denotes	(
T23902	44762-44772	RB	denotes	downstream
T23903	44738-44742	IN	denotes	from
T23904	44743-44746	CD	denotes	366
T23905	44747-44749	NNS	denotes	bp
T23906	44750-44752	IN	denotes	to
T23907	44753-44758	CD	denotes	2,773
T23908	44759-44761	NNS	denotes	bp
T23909	44773-44775	IN	denotes	of
T23910	44776-44780	NN	denotes	exon
T23911	44781-44782	CD	denotes	3
T23912	44782-44783	-RRB-	denotes	)
T23913	44784-44793	VBN	denotes	generated
T23914	44794-44796	IN	denotes	by
T23915	44797-44800	NN	denotes	PCR
T23916	44800-44801	.	denotes	.
T23917	44801-44926	sentence	denotes	5′ to Pgk-neo, we inserted an EcoRI/NotI PCR fragment extending from 4,107 bp to 336 bp 5′ of the Dmrt7 translational start.
T23918	44802-44803	CD	denotes	5
T23919	44820-44828	VBD	denotes	inserted
T23920	44803-44804	SYM	denotes	′
T23921	44805-44807	IN	denotes	to
T23922	44808-44811	NN	denotes	Pgk
T23923	44812-44815	NN	denotes	neo
T23924	44811-44812	HYPH	denotes	-
T23925	44815-44817	,	denotes	,
T23926	44817-44819	PRP	denotes	we
T23927	44829-44831	DT	denotes	an
T23928	44847-44855	NN	denotes	fragment
T23929	44832-44837	NN	denotes	EcoRI
T23930	44838-44842	NN	denotes	NotI
T23931	44837-44838	HYPH	denotes	/
T23932	44843-44846	NN	denotes	PCR
T23933	44856-44865	VBG	denotes	extending
T23934	44866-44870	IN	denotes	from
T23935	44871-44876	CD	denotes	4,107
T23936	44877-44879	NNS	denotes	bp
T23937	44880-44882	IN	denotes	to
T23938	44883-44886	CD	denotes	336
T23939	44887-44889	NNS	denotes	bp
T23940	44890-44891	CD	denotes	5
T23941	44891-44892	SYM	denotes	′
T23942	44893-44895	IN	denotes	of
T23943	44896-44899	DT	denotes	the
T23944	44920-44925	NN	denotes	start
T23945	44900-44905	NN	denotes	Dmrt7
T23946	44906-44919	JJ	denotes	translational
T23947	44925-44926	.	denotes	.
T23948	44926-45017	sentence	denotes	Finally, we inserted a loxP site and NotI site 336 bp 5′ of the Dmrt7 translational start.
T23949	44927-44934	RB	denotes	Finally
T23950	44939-44947	VBD	denotes	inserted
T23951	44934-44936	,	denotes	,
T23952	44936-44938	PRP	denotes	we
T23953	44948-44949	DT	denotes	a
T23954	44955-44959	NN	denotes	site
T23955	44950-44954	NN	denotes	loxP
T23956	44960-44963	CC	denotes	and
T23957	44964-44968	NN	denotes	NotI
T23958	44969-44973	NN	denotes	site
T23959	44974-44977	CD	denotes	336
T23960	44978-44980	NNS	denotes	bp
T23961	44981-44982	CD	denotes	5
T23962	44982-44983	SYM	denotes	′
T23963	44984-44986	IN	denotes	of
T23964	44987-44990	DT	denotes	the
T23965	45011-45016	NN	denotes	start
T23966	44991-44996	NN	denotes	Dmrt7
T23967	44997-45010	JJ	denotes	translational
T23968	45016-45017	.	denotes	.
T23969	45017-45114	sentence	denotes	In the resulting vector, the second and third exons of Dmrt7 are flanked by loxP sites (floxed).
T23970	45018-45020	IN	denotes	In
T23971	45083-45090	VBN	denotes	flanked
T23972	45021-45024	DT	denotes	the
T23973	45035-45041	NN	denotes	vector
T23974	45025-45034	VBG	denotes	resulting
T23975	45041-45043	,	denotes	,
T23976	45043-45046	DT	denotes	the
T23977	45064-45069	NNS	denotes	exons
T23978	45047-45053	JJ	denotes	second
T23979	45054-45057	CC	denotes	and
T23980	45058-45063	JJ	denotes	third
T23981	45070-45072	IN	denotes	of
T23982	45073-45078	NN	denotes	Dmrt7
T23983	45079-45082	VBP	denotes	are
T23984	45091-45093	IN	denotes	by
T23985	45094-45098	NN	denotes	loxP
T23986	45099-45104	NNS	denotes	sites
T23987	45105-45106	-LRB-	denotes	(
T23988	45106-45112	JJ	denotes	floxed
T23989	45112-45113	-RRB-	denotes	)
T23990	45113-45114	.	denotes	.
T23991	45114-45181	sentence	denotes	The Dmrt7-containing portions of pDZ169 were completely sequenced.
T23992	45115-45118	DT	denotes	The
T23993	45136-45144	NNS	denotes	portions
T23994	45119-45124	NN	denotes	Dmrt7
T23995	45125-45135	VBG	denotes	containing
T23996	45124-45125	HYPH	denotes	-
T23997	45171-45180	VBN	denotes	sequenced
T23998	45145-45147	IN	denotes	of
T23999	45148-45154	NN	denotes	pDZ169
T24000	45155-45159	VBD	denotes	were
T24001	45160-45170	RB	denotes	completely
T24002	45180-45181	.	denotes	.
T24003	45181-45294	sentence	denotes	pDZ169 was linearized with PmeI and electroporated into CJ7 ES cells (originally derived from the 129S1 strain).
T24004	45182-45188	NN	denotes	pDZ169
T24005	45193-45203	VBN	denotes	linearized
T24006	45189-45192	VBD	denotes	was
T24007	45204-45208	IN	denotes	with
T24008	45209-45213	NN	denotes	PmeI
T24009	45214-45217	CC	denotes	and
T24010	45218-45232	VBN	denotes	electroporated
T24011	45233-45237	IN	denotes	into
T24012	45238-45241	NN	denotes	CJ7
T24013	45245-45250	NNS	denotes	cells
T24014	45242-45244	NN	denotes	ES
T24015	45251-45252	-LRB-	denotes	(
T24016	45252-45262	RB	denotes	originally
T24017	45263-45270	VBN	denotes	derived
T24018	45271-45275	IN	denotes	from
T24019	45276-45279	DT	denotes	the
T24020	45286-45292	NN	denotes	strain
T24021	45280-45285	NN	denotes	129S1
T24022	45292-45293	-RRB-	denotes	)
T24023	45293-45294	.	denotes	.
T24024	45294-45502	sentence	denotes	Three homologous recombinants were identified from 296 G418-resistant colonies by Southern hybridization by use of a DNA probe from the sequences upstream of exon 1 to screen genomic DNA digested with EcoRI.
T24025	45295-45300	CD	denotes	Three
T24026	45312-45324	NNS	denotes	recombinants
T24027	45301-45311	JJ	denotes	homologous
T24028	45330-45340	VBN	denotes	identified
T24029	45325-45329	VBD	denotes	were
T24030	45341-45345	IN	denotes	from
T24031	45346-45349	CD	denotes	296
T24032	45365-45373	NNS	denotes	colonies
T24033	45350-45354	NN	denotes	G418
T24034	45355-45364	JJ	denotes	resistant
T24035	45354-45355	HYPH	denotes	-
T24036	45374-45376	IN	denotes	by
T24037	45377-45385	NNP	denotes	Southern
T24038	45386-45399	NN	denotes	hybridization
T24039	45400-45402	IN	denotes	by
T24040	45403-45406	NN	denotes	use
T24041	45407-45409	IN	denotes	of
T24042	45410-45411	DT	denotes	a
T24043	45416-45421	NN	denotes	probe
T24044	45412-45415	NN	denotes	DNA
T24045	45422-45426	IN	denotes	from
T24046	45427-45430	DT	denotes	the
T24047	45431-45440	NNS	denotes	sequences
T24048	45441-45449	RB	denotes	upstream
T24049	45450-45452	IN	denotes	of
T24050	45453-45457	NN	denotes	exon
T24051	45458-45459	CD	denotes	1
T24052	45460-45462	TO	denotes	to
T24053	45463-45469	VB	denotes	screen
T24054	45470-45477	JJ	denotes	genomic
T24055	45478-45481	NN	denotes	DNA
T24056	45482-45490	VBN	denotes	digested
T24057	45491-45495	IN	denotes	with
T24058	45496-45501	NN	denotes	EcoRI
T24059	45501-45502	.	denotes	.
T24060	45502-45604	sentence	denotes	Homologous recombination was confirmed on both ends of the targeted region by Southern hybridization.
T24061	45503-45513	JJ	denotes	Homologous
T24062	45514-45527	NN	denotes	recombination
T24063	45532-45541	VBN	denotes	confirmed
T24064	45528-45531	VBD	denotes	was
T24065	45542-45544	IN	denotes	on
T24066	45545-45549	DT	denotes	both
T24067	45550-45554	NNS	denotes	ends
T24068	45555-45557	IN	denotes	of
T24069	45558-45561	DT	denotes	the
T24070	45571-45577	NN	denotes	region
T24071	45562-45570	VBN	denotes	targeted
T24072	45578-45580	IN	denotes	by
T24073	45581-45589	NNP	denotes	Southern
T24074	45590-45603	NN	denotes	hybridization
T24075	45603-45604	.	denotes	.
T24076	45604-45738	sentence	denotes	Probes for Southern hybridization were made by PCR using primers DM5S10/DM5S11 (5′ probe) and DM5PR1/DM5PR2 (3′ probe), listed below.
T24077	45605-45611	NNS	denotes	Probes
T24078	45644-45648	VBN	denotes	made
T24079	45612-45615	IN	denotes	for
T24080	45616-45624	NNP	denotes	Southern
T24081	45625-45638	NN	denotes	hybridization
T24082	45639-45643	VBD	denotes	were
T24083	45649-45651	IN	denotes	by
T24084	45652-45655	NN	denotes	PCR
T24085	45656-45661	VBG	denotes	using
T24086	45662-45669	NNS	denotes	primers
T24087	45677-45683	NN	denotes	DM5S11
T24088	45670-45676	NN	denotes	DM5S10
T24089	45676-45677	HYPH	denotes	/
T24090	45684-45685	-LRB-	denotes	(
T24091	45688-45693	NN	denotes	probe
T24092	45685-45686	CD	denotes	5
T24093	45686-45687	SYM	denotes	′
T24094	45693-45694	-RRB-	denotes	)
T24095	45695-45698	CC	denotes	and
T24096	45699-45705	NN	denotes	DM5PR1
T24097	45706-45712	NN	denotes	DM5PR2
T24098	45705-45706	HYPH	denotes	/
T24099	45713-45714	-LRB-	denotes	(
T24100	45717-45722	NN	denotes	probe
T24101	45714-45715	CD	denotes	3
T24102	45715-45716	SYM	denotes	′
T24103	45722-45723	-RRB-	denotes	)
T24104	45723-45725	,	denotes	,
T24105	45725-45731	VBN	denotes	listed
T24106	45732-45737	RB	denotes	below
T24107	45737-45738	.	denotes	.
T24108	45738-45865	sentence	denotes	Two targeted ES cell clones containing the floxed allele Dmrt7neo were injected into C57Bl/6 blastocysts to generate chimeras.
T24109	45739-45742	CD	denotes	Two
T24110	45760-45766	NNS	denotes	clones
T24111	45743-45751	VBN	denotes	targeted
T24112	45752-45754	NN	denotes	ES
T24113	45755-45759	NN	denotes	cell
T24114	45810-45818	VBN	denotes	injected
T24115	45767-45777	VBG	denotes	containing
T24116	45778-45781	DT	denotes	the
T24117	45789-45795	NN	denotes	allele
T24118	45782-45788	VBN	denotes	floxed
T24119	45796-45804	NN	denotes	Dmrt7neo
T24120	45805-45809	VBD	denotes	were
T24121	45819-45823	IN	denotes	into
T24122	45824-45829	NN	denotes	C57Bl
T24123	45832-45843	NNS	denotes	blastocysts
T24124	45829-45830	HYPH	denotes	/
T24125	45830-45831	CD	denotes	6
T24126	45844-45846	TO	denotes	to
T24127	45847-45855	VB	denotes	generate
T24128	45856-45864	NNS	denotes	chimeras
T24129	45864-45865	.	denotes	.
T24130	45865-45956	sentence	denotes	Chimeric males were bred with C57Bl/6 females to generate heterozygotes carrying Dmrt7neo.
T24131	45866-45874	JJ	denotes	Chimeric
T24132	45875-45880	NNS	denotes	males
T24133	45886-45890	VBN	denotes	bred
T24134	45881-45885	VBD	denotes	were
T24135	45891-45895	IN	denotes	with
T24136	45896-45901	NN	denotes	C57Bl
T24137	45904-45911	NNS	denotes	females
T24138	45901-45902	HYPH	denotes	/
T24139	45902-45903	CD	denotes	6
T24140	45912-45914	TO	denotes	to
T24141	45915-45923	VB	denotes	generate
T24142	45924-45937	NNS	denotes	heterozygotes
T24143	45938-45946	VBG	denotes	carrying
T24144	45947-45955	NN	denotes	Dmrt7neo
T24145	45955-45956	.	denotes	.
T24146	45956-46175	sentence	denotes	Dmrt7+/Dmrt7neo females were bred with male β-actin-Cre transgenic mice to delete the floxed sequences and generate heterozygous Dmrt7− /+ deletion mutants, which were interbred to generate homozygous Dmrt7−/− mutants.
T24147	45957-45962	NN	denotes	Dmrt7
T24148	45973-45980	NNS	denotes	females
T24149	45962-45963	SYM	denotes	+
T24150	45963-45964	HYPH	denotes	/
T24151	45964-45972	NN	denotes	Dmrt7neo
T24152	45986-45990	VBN	denotes	bred
T24153	45981-45985	VBD	denotes	were
T24154	45991-45995	IN	denotes	with
T24155	45996-46000	JJ	denotes	male
T24156	46024-46028	NNS	denotes	mice
T24157	46001-46002	NN	denotes	β
T24158	46003-46008	NN	denotes	actin
T24159	46002-46003	HYPH	denotes	-
T24160	46009-46012	NN	denotes	Cre
T24161	46008-46009	HYPH	denotes	-
T24162	46013-46023	JJ	denotes	transgenic
T24163	46029-46031	TO	denotes	to
T24164	46032-46038	VB	denotes	delete
T24165	46039-46042	DT	denotes	the
T24166	46050-46059	NNS	denotes	sequences
T24167	46043-46049	VBN	denotes	floxed
T24168	46060-46063	CC	denotes	and
T24169	46064-46072	VB	denotes	generate
T24170	46073-46085	JJ	denotes	heterozygous
T24171	46105-46112	NNS	denotes	mutants
T24172	46086-46091	NN	denotes	Dmrt7
T24173	46091-46092	SYM	denotes	−
T24174	46093-46094	HYPH	denotes	/
T24175	46094-46095	SYM	denotes	+
T24176	46096-46104	NN	denotes	deletion
T24177	46112-46114	,	denotes	,
T24178	46114-46119	WDT	denotes	which
T24179	46125-46134	VBN	denotes	interbred
T24180	46120-46124	VBD	denotes	were
T24181	46135-46137	TO	denotes	to
T24182	46138-46146	VB	denotes	generate
T24183	46147-46157	JJ	denotes	homozygous
T24184	46167-46174	NNS	denotes	mutants
T24185	46158-46163	NN	denotes	Dmrt7
T24186	46163-46164	SYM	denotes	−
T24187	46164-46165	HYPH	denotes	/
T24188	46165-46166	SYM	denotes	−
T24189	46174-46175	.	denotes	.
T27915	11195-11196	HYPH	denotes	-
T24486	46177-46187	NN	denotes	Genotyping
T24487	46188-46191	CC	denotes	and
T24488	46192-46194	NN	denotes	RT
T24489	46195-46198	NN	denotes	PCR
T24490	46194-46195	HYPH	denotes	-
T24491	46198-46199	.	denotes	.
T24492	46199-46258	sentence	denotes	For genotyping, tail-clip DNA was amplified for 35 cycles.
T24493	46200-46203	IN	denotes	For
T24494	46234-46243	VBN	denotes	amplified
T24495	46204-46214	NN	denotes	genotyping
T24496	46214-46216	,	denotes	,
T24497	46216-46220	NN	denotes	tail
T24498	46221-46225	NN	denotes	clip
T24499	46220-46221	HYPH	denotes	-
T24500	46226-46229	NN	denotes	DNA
T24501	46230-46233	VBD	denotes	was
T24502	46244-46247	IN	denotes	for
T24503	46248-46250	CD	denotes	35
T24504	46251-46257	NNS	denotes	cycles
T24505	46257-46258	.	denotes	.
T24506	46258-46347	sentence	denotes	Chromosomal sex was determined by PCR with primers to the Y chromosome gene Zfy (below).
T24507	46259-46270	JJ	denotes	Chromosomal
T24508	46271-46274	NN	denotes	sex
T24509	46279-46289	VBN	denotes	determined
T24510	46275-46278	VBD	denotes	was
T24511	46290-46292	IN	denotes	by
T24512	46293-46296	NN	denotes	PCR
T24513	46297-46301	IN	denotes	with
T24514	46302-46309	NNS	denotes	primers
T24515	46310-46312	IN	denotes	to
T24516	46313-46316	DT	denotes	the
T24517	46330-46334	NN	denotes	gene
T24518	46317-46318	NN	denotes	Y
T24519	46319-46329	NN	denotes	chromosome
T24520	46335-46338	NN	denotes	Zfy
T24521	46339-46340	-LRB-	denotes	(
T24522	46340-46345	RB	denotes	below
T24523	46345-46346	-RRB-	denotes	)
T24524	46346-46347	.	denotes	.
T24525	46347-46459	sentence	denotes	The wild-type Dmrt7 allele Dmrt7+ was detected by PCR with DM5S4/DM5S5, with an annealing temperature of 60 °C.
T24526	46348-46351	DT	denotes	The
T24527	46368-46374	NN	denotes	allele
T24528	46352-46356	JJ	denotes	wild
T24529	46357-46361	NN	denotes	type
T24530	46356-46357	HYPH	denotes	-
T24531	46362-46367	NN	denotes	Dmrt7
T24532	46386-46394	VBN	denotes	detected
T24533	46375-46380	NN	denotes	Dmrt7
T24534	46380-46381	SYM	denotes	+
T24535	46382-46385	VBD	denotes	was
T24536	46395-46397	IN	denotes	by
T24537	46398-46401	NN	denotes	PCR
T24538	46402-46406	IN	denotes	with
T24539	46407-46412	NN	denotes	DM5S4
T24540	46413-46418	NN	denotes	DM5S5
T24541	46412-46413	HYPH	denotes	/
T24542	46418-46420	,	denotes	,
T24543	46420-46424	IN	denotes	with
T24544	46425-46427	DT	denotes	an
T24545	46438-46449	NN	denotes	temperature
T24546	46428-46437	JJ	denotes	annealing
T24547	46450-46452	IN	denotes	of
T24548	46453-46455	CD	denotes	60
T24549	46456-46458	NN	denotes	°C
T24550	46458-46459	.	denotes	.
T24551	46459-46560	sentence	denotes	The Dmrt7flox allele was detected by PCR with DM5S5F/DM7KO7R with an annealing temperature of 62 °C.
T24552	46460-46463	DT	denotes	The
T24553	46474-46480	NN	denotes	allele
T24554	46464-46473	NN	denotes	Dmrt7flox
T24555	46485-46493	VBN	denotes	detected
T24556	46481-46484	VBD	denotes	was
T24557	46494-46496	IN	denotes	by
T24558	46497-46500	NN	denotes	PCR
T24559	46501-46505	IN	denotes	with
T24560	46506-46512	NN	denotes	DM5S5F
T24561	46513-46520	NN	denotes	DM7KO7R
T24562	46512-46513	HYPH	denotes	/
T24563	46521-46525	IN	denotes	with
T24564	46526-46528	DT	denotes	an
T24565	46539-46550	NN	denotes	temperature
T24566	46529-46538	JJ	denotes	annealing
T24567	46551-46553	IN	denotes	of
T24568	46554-46556	CD	denotes	62
T24569	46557-46559	NN	denotes	°C
T24570	46559-46560	.	denotes	.
T24571	46560-46664	sentence	denotes	The deleted Dmrt7 allele Dmrt7− was detected with DM5S3/DM7KO7R with an annealing temperature of 62 °C.
T24572	46561-46564	DT	denotes	The
T24573	46579-46585	NN	denotes	allele
T24574	46565-46572	VBN	denotes	deleted
T24575	46573-46578	NN	denotes	Dmrt7
T24576	46597-46605	VBN	denotes	detected
T24577	46586-46591	NN	denotes	Dmrt7
T24578	46591-46592	SYM	denotes	−
T24579	46593-46596	VBD	denotes	was
T24580	46606-46610	IN	denotes	with
T24581	46611-46616	NN	denotes	DM5S3
T24582	46617-46624	NN	denotes	DM7KO7R
T24583	46616-46617	HYPH	denotes	/
T24584	46625-46629	IN	denotes	with
T24585	46630-46632	DT	denotes	an
T24586	46643-46654	NN	denotes	temperature
T24587	46633-46642	JJ	denotes	annealing
T24588	46655-46657	IN	denotes	of
T24589	46658-46660	CD	denotes	62
T24590	46661-46663	NN	denotes	°C
T24591	46663-46664	.	denotes	.
T24592	46664-46789	sentence	denotes	RT-PCR for Dmrt7 expression analysis was as described [23] using primers SK111/SK112 with an annealing temperature of 62 °C.
T24593	46665-46667	NN	denotes	RT
T24594	46668-46671	NN	denotes	PCR
T24595	46667-46668	HYPH	denotes	-
T24596	46702-46705	VBD	denotes	was
T24597	46672-46675	IN	denotes	for
T24598	46676-46681	NN	denotes	Dmrt7
T24599	46682-46692	NN	denotes	expression
T24600	46693-46701	NN	denotes	analysis
T24601	46706-46708	IN	denotes	as
T24602	46709-46718	VBN	denotes	described
T24603	46719-46720	-LRB-	denotes	[
T24604	46720-46722	CD	denotes	23
T24605	46722-46723	-RRB-	denotes	]
T24606	46724-46729	VBG	denotes	using
T24607	46730-46737	NNS	denotes	primers
T24608	46744-46749	NN	denotes	SK112
T24609	46738-46743	NN	denotes	SK111
T24610	46743-46744	HYPH	denotes	/
T24611	46750-46754	IN	denotes	with
T24612	46755-46757	DT	denotes	an
T24613	46768-46779	NN	denotes	temperature
T24614	46758-46767	NN	denotes	annealing
T24615	46780-46782	IN	denotes	of
T24616	46783-46785	CD	denotes	62
T24617	46786-46788	NNS	denotes	°C
T24618	46788-46789	.	denotes	.
T24840	46791-46798	NNS	denotes	Primers
T24841	46798-46799	.	denotes	.
T24842	46799-46837	sentence	denotes	DM5S3: 5′-AGAGTGGATTGAATCGGATAGCTC-3′
T24843	46800-46805	NN	denotes	DM5S3
T24844	46805-46807	:	denotes	:
T24845	46807-46808	CD	denotes	5
T24846	46810-46834	NN	denotes	AGAGTGGATTGAATCGGATAGCTC
T24847	46808-46809	SYM	denotes	′
T24848	46809-46810	HYPH	denotes	-
T24849	46834-46835	HYPH	denotes	-
T24850	46835-46836	CD	denotes	3
T24851	46836-46837	SYM	denotes	′
T24852	46837-46875	sentence	denotes	DM5S4: 5′-AGGATCTTAGTGTCGAATGAATAC-3′
T24853	46838-46843	NN	denotes	DM5S4
T24854	46843-46845	:	denotes	:
T24855	46845-46846	CD	denotes	5
T24856	46848-46872	NN	denotes	AGGATCTTAGTGTCGAATGAATAC
T24857	46846-46847	SYM	denotes	′
T24858	46847-46848	HYPH	denotes	-
T24859	46872-46873	HYPH	denotes	-
T24860	46873-46874	CD	denotes	3
T24861	46874-46875	SYM	denotes	′
T24862	46875-46913	sentence	denotes	DM5S5: 5′-CCCTTATCCTCCTGCATCCAGATC-3′
T24863	46876-46881	NN	denotes	DM5S5
T24864	46881-46883	:	denotes	:
T24865	46883-46884	CD	denotes	5
T24866	46886-46910	NN	denotes	CCCTTATCCTCCTGCATCCAGATC
T24867	46884-46885	SYM	denotes	′
T24868	46885-46886	HYPH	denotes	-
T24869	46910-46911	HYPH	denotes	-
T24870	46911-46912	CD	denotes	3
T24871	46912-46913	SYM	denotes	′
T24872	46913-46952	sentence	denotes	DM5S10: 5′-CAGGCTATGGTTAGACTTGAGCAC-3′
T24873	46914-46920	NN	denotes	DM5S10
T24874	46920-46922	:	denotes	:
T24875	46922-46923	CD	denotes	5
T24876	46925-46949	NN	denotes	CAGGCTATGGTTAGACTTGAGCAC
T24877	46923-46924	SYM	denotes	′
T24878	46924-46925	HYPH	denotes	-
T24879	46949-46950	HYPH	denotes	-
T24880	46950-46951	CD	denotes	3
T24881	46951-46952	SYM	denotes	′
T24882	46952-46991	sentence	denotes	DM5S11: 5′-CATCACTCGCGGACAAAGATGCAG-3′
T24883	46953-46959	NN	denotes	DM5S11
T24884	46959-46961	:	denotes	:
T24885	46961-46962	CD	denotes	5
T24886	46964-46988	NN	denotes	CATCACTCGCGGACAAAGATGCAG
T24887	46962-46963	SYM	denotes	′
T24888	46963-46964	HYPH	denotes	-
T24889	46988-46989	HYPH	denotes	-
T24890	46989-46990	CD	denotes	3
T24891	46990-46991	SYM	denotes	′
T24892	46991-47030	sentence	denotes	DM5PR1: 5′-CTTCTGCTACAGCCACAGGTCTGG-3′
T24893	46992-46998	NN	denotes	DM5PR1
T24894	46998-47000	:	denotes	:
T24895	47000-47001	CD	denotes	5
T24896	47003-47027	NN	denotes	CTTCTGCTACAGCCACAGGTCTGG
T24897	47001-47002	SYM	denotes	′
T24898	47002-47003	HYPH	denotes	-
T24899	47027-47028	HYPH	denotes	-
T24900	47028-47029	CD	denotes	3
T24901	47029-47030	SYM	denotes	′
T24902	47030-47067	sentence	denotes	DM5PR2: 5′-GAATTCAACTAGTATCTGTCCC-3′
T24903	47031-47037	NN	denotes	DM5PR2
T24904	47037-47039	:	denotes	:
T24905	47039-47040	CD	denotes	5
T24906	47042-47064	NN	denotes	GAATTCAACTAGTATCTGTCCC
T24907	47040-47041	SYM	denotes	′
T24908	47041-47042	HYPH	denotes	-
T24909	47064-47065	HYPH	denotes	-
T24910	47065-47066	CD	denotes	3
T24911	47066-47067	SYM	denotes	′
T24912	47067-47108	sentence	denotes	DM7KO7R: 5′-CGAGGATCAAGCTCAGGTCACTAGG-3′
T24913	47068-47075	NN	denotes	DM7KO7R
T24914	47075-47077	:	denotes	:
T24915	47077-47078	CD	denotes	5
T24916	47080-47105	NN	denotes	CGAGGATCAAGCTCAGGTCACTAGG
T24917	47078-47079	SYM	denotes	′
T24918	47079-47080	HYPH	denotes	-
T24919	47105-47106	HYPH	denotes	-
T24920	47106-47107	CD	denotes	3
T24921	47107-47108	SYM	denotes	′
T24922	47108-47147	sentence	denotes	DM5S5F: 5′-GATCTGGATGCAGGAGGATAAGGG-3′
T24923	47109-47115	NN	denotes	DM5S5F
T24924	47115-47117	:	denotes	:
T24925	47117-47118	CD	denotes	5
T24926	47120-47144	NN	denotes	GATCTGGATGCAGGAGGATAAGGG
T24927	47118-47119	SYM	denotes	′
T24928	47119-47120	HYPH	denotes	-
T24929	47144-47145	HYPH	denotes	-
T24930	47145-47146	CD	denotes	3
T24931	47146-47147	SYM	denotes	′
T24932	47147-47186	sentence	denotes	ZFYF: 5′-CCTATTGCATGGACAGCAGTCTTATG-3′
T24933	47148-47152	NN	denotes	ZFYF
T24934	47152-47154	:	denotes	:
T24935	47154-47155	CD	denotes	5
T24936	47157-47183	NN	denotes	CCTATTGCATGGACAGCAGTCTTATG
T24937	47155-47156	SYM	denotes	′
T24938	47156-47157	HYPH	denotes	-
T24939	47183-47184	HYPH	denotes	-
T24940	47184-47185	CD	denotes	3
T24941	47185-47186	SYM	denotes	′
T24942	47186-47226	sentence	denotes	ZFYR: 5′-GACTAGACATGTTCTTAACATCTGTCC-3′
T24943	47187-47191	NN	denotes	ZFYR
T24944	47191-47193	:	denotes	:
T24945	47193-47194	CD	denotes	5
T24946	47196-47223	NN	denotes	GACTAGACATGTTCTTAACATCTGTCC
T24947	47194-47195	SYM	denotes	′
T24948	47195-47196	HYPH	denotes	-
T24949	47223-47224	HYPH	denotes	-
T24950	47224-47225	CD	denotes	3
T24951	47225-47226	SYM	denotes	′
T24952	47226-47264	sentence	denotes	SK111: 5′-CCCTTCTGGAAAAGAGAACATAGC-3′
T24953	47227-47232	NN	denotes	SK111
T24954	47232-47234	:	denotes	:
T24955	47234-47235	CD	denotes	5
T24956	47237-47261	NN	denotes	CCCTTCTGGAAAAGAGAACATAGC
T24957	47235-47236	SYM	denotes	′
T24958	47236-47237	HYPH	denotes	-
T24959	47261-47262	HYPH	denotes	-
T24960	47262-47263	CD	denotes	3
T24961	47263-47264	SYM	denotes	′
T24962	47264-47302	sentence	denotes	SK112: 5′-GCTCCAGGGGCCTGTGGCTGTAGC-3′
T24963	47265-47270	NN	denotes	SK112
T24964	47270-47272	:	denotes	:
T24965	47272-47273	CD	denotes	5
T24966	47275-47299	NN	denotes	GCTCCAGGGGCCTGTGGCTGTAGC
T24967	47273-47274	SYM	denotes	′
T24968	47274-47275	HYPH	denotes	-
T24969	47299-47300	HYPH	denotes	-
T24970	47300-47301	CD	denotes	3
T24971	47301-47302	SYM	denotes	′
T24972	47302-47339	sentence	denotes	β-actinF: 5′-TGCGTGACATCAAAGAGAAG-3′
T24973	47303-47304	NN	denotes	β
T24974	47305-47311	NN	denotes	actinF
T24975	47304-47305	HYPH	denotes	-
T24976	47311-47313	:	denotes	:
T24977	47313-47314	CD	denotes	5
T24978	47316-47336	NN	denotes	TGCGTGACATCAAAGAGAAG
T24979	47314-47315	SYM	denotes	′
T24980	47315-47316	HYPH	denotes	-
T24981	47336-47337	HYPH	denotes	-
T24982	47337-47338	CD	denotes	3
T24983	47338-47339	SYM	denotes	′
T24984	47339-47375	sentence	denotes	β-actinR: 5′-GATGCCACAGGATTCCATA-3′
T24985	47340-47341	NN	denotes	β
T24986	47342-47348	NN	denotes	actinR
T24987	47341-47342	HYPH	denotes	-
T24988	47348-47350	:	denotes	:
T24989	47350-47351	CD	denotes	5
T24990	47353-47372	NN	denotes	GATGCCACAGGATTCCATA
T24991	47351-47352	SYM	denotes	′
T24992	47352-47353	HYPH	denotes	-
T24993	47372-47373	HYPH	denotes	-
T24994	47373-47374	CD	denotes	3
T24995	47374-47375	SYM	denotes	′
T25224	47390-47398	NN	denotes	analysis
T25223	47377-47389	JJ	denotes	Histological
T25225	47399-47402	CC	denotes	and
T25226	47403-47408	NN	denotes	TUNEL
T25227	47409-47414	NN	denotes	assay
T25228	47414-47415	.	denotes	.
T25229	47415-47596	sentence	denotes	Dissected testes were fixed in Bouin's fixative or phosphate-buffered formalin overnight at 4 °C, progressively dehydrated in a graded ethanol series, and embedded in paraffin wax.
T25230	47416-47425	VBN	denotes	Dissected
T25231	47426-47432	NNS	denotes	testes
T25232	47438-47443	VBN	denotes	fixed
T25233	47433-47437	VBD	denotes	were
T25234	47444-47446	IN	denotes	in
T25235	47447-47452	NNP	denotes	Bouin
T25236	47455-47463	NN	denotes	fixative
T25237	47452-47454	POS	denotes	's
T25238	47464-47466	CC	denotes	or
T25239	47467-47476	NN	denotes	phosphate
T25240	47477-47485	VBN	denotes	buffered
T25241	47476-47477	HYPH	denotes	-
T25242	47486-47494	NN	denotes	formalin
T25243	47495-47504	RB	denotes	overnight
T25244	47505-47507	IN	denotes	at
T25245	47508-47509	CD	denotes	4
T25246	47510-47512	NN	denotes	°C
T25247	47512-47514	,	denotes	,
T25248	47514-47527	RB	denotes	progressively
T25249	47528-47538	VBN	denotes	dehydrated
T25250	47539-47541	IN	denotes	in
T25251	47542-47543	DT	denotes	a
T25252	47559-47565	NN	denotes	series
T25253	47544-47550	VBN	denotes	graded
T25254	47551-47558	NN	denotes	ethanol
T25255	47565-47567	,	denotes	,
T25256	47567-47570	CC	denotes	and
T25257	47571-47579	VBN	denotes	embedded
T25258	47580-47582	IN	denotes	in
T25259	47583-47591	NN	denotes	paraffin
T25260	47592-47595	NN	denotes	wax
T25261	47595-47596	.	denotes	.
T25262	47596-47685	sentence	denotes	Sections (6 μm) were deparaffinized, rehydrated, and stained with hematoxylin and eosin.
T25263	47597-47605	NNS	denotes	Sections
T25264	47618-47632	VBN	denotes	deparaffinized
T25265	47606-47607	-LRB-	denotes	(
T25266	47609-47611	NNS	denotes	μm
T25267	47607-47608	CD	denotes	6
T25268	47611-47612	-RRB-	denotes	)
T25269	47613-47617	VBD	denotes	were
T25270	47632-47634	,	denotes	,
T25271	47634-47644	VBN	denotes	rehydrated
T25272	47644-47646	,	denotes	,
T25273	47646-47649	CC	denotes	and
T25274	47650-47657	VBN	denotes	stained
T25275	47658-47662	IN	denotes	with
T25276	47663-47674	NN	denotes	hematoxylin
T25277	47675-47678	CC	denotes	and
T25278	47679-47684	NN	denotes	eosin
T25279	47684-47685	.	denotes	.
T25280	47685-47848	sentence	denotes	For TUNEL analyses, deparaffinized sections were treated with proteinase K for 15 min and quenched in 3.0% hydrogen peroxide in PBS for 5 min at room temperature.
T25281	47686-47689	IN	denotes	For
T25282	47735-47742	VBN	denotes	treated
T25283	47690-47695	NN	denotes	TUNEL
T25284	47696-47704	NNS	denotes	analyses
T25285	47704-47706	,	denotes	,
T25286	47706-47720	VBN	denotes	deparaffinized
T25287	47721-47729	NNS	denotes	sections
T25288	47730-47734	VBD	denotes	were
T25289	47743-47747	IN	denotes	with
T25290	47748-47758	NN	denotes	proteinase
T25291	47759-47760	NN	denotes	K
T25292	47761-47764	IN	denotes	for
T25293	47765-47767	CD	denotes	15
T25294	47768-47771	NNS	denotes	min
T25295	47772-47775	CC	denotes	and
T25296	47776-47784	VBN	denotes	quenched
T25297	47785-47787	IN	denotes	in
T25298	47788-47791	CD	denotes	3.0
T25299	47791-47792	NN	denotes	%
T25300	47802-47810	NN	denotes	peroxide
T25301	47793-47801	NN	denotes	hydrogen
T25302	47811-47813	IN	denotes	in
T25303	47814-47817	NN	denotes	PBS
T25304	47818-47821	IN	denotes	for
T25305	47822-47823	CD	denotes	5
T25306	47824-47827	NNS	denotes	min
T25307	47828-47830	IN	denotes	at
T25308	47831-47835	NN	denotes	room
T25309	47836-47847	NN	denotes	temperature
T25310	47847-47848	.	denotes	.
T25311	47848-48011	sentence	denotes	Subsequently, nuclear staining in apoptotic cells was detected using ApopTag kit (Chemicon, http://www.chemicon.com) according to the manufacturer's instructions.
T25312	47849-47861	RB	denotes	Subsequently
T25313	47903-47911	VBN	denotes	detected
T25314	47861-47863	,	denotes	,
T25315	47863-47870	JJ	denotes	nuclear
T25316	47871-47879	NN	denotes	staining
T25317	47880-47882	IN	denotes	in
T25318	47883-47892	JJ	denotes	apoptotic
T25319	47893-47898	NNS	denotes	cells
T25320	47899-47902	VBD	denotes	was
T25321	47912-47917	VBG	denotes	using
T25322	47918-47925	NN	denotes	ApopTag
T25323	47926-47929	NN	denotes	kit
T25324	47930-47931	-LRB-	denotes	(
T25325	47931-47939	NNP	denotes	Chemicon
T25326	47939-47941	,	denotes	,
T25327	47941-47964	NN	denotes	http://www.chemicon.com
T25328	47964-47965	-RRB-	denotes	)
T25329	47966-47975	VBG	denotes	according
T25330	47976-47978	IN	denotes	to
T25331	47979-47982	DT	denotes	the
T25332	47983-47995	NN	denotes	manufacturer
T25333	47998-48010	NNS	denotes	instructions
T25334	47995-47997	POS	denotes	's
T25335	48010-48011	.	denotes	.
T25519	48141-48143	NN	denotes	mM
T25494	48013-48019	NN	denotes	Tissue
T25495	48038-48046	NN	denotes	staining
T25496	48020-48037	JJ	denotes	immunofluorescent
T25497	48046-48047	.	denotes	.
T25498	48047-48190	sentence	denotes	Slides with paraffin sections were washed in PBT (0.1% Tween 20 in PBS) and autoclaved in 10 mM citric acid (pH 6.0) to retrieve antigenicity.
T25499	48048-48054	NNS	denotes	Slides
T25500	48083-48089	VBN	denotes	washed
T25501	48055-48059	IN	denotes	with
T25502	48060-48068	NN	denotes	paraffin
T25503	48069-48077	NNS	denotes	sections
T25504	48078-48082	VBD	denotes	were
T25505	48090-48092	IN	denotes	in
T25506	48093-48096	NN	denotes	PBT
T25507	48097-48098	-LRB-	denotes	(
T25508	48103-48108	NN	denotes	Tween
T25509	48098-48101	CD	denotes	0.1
T25510	48101-48102	NN	denotes	%
T25511	48109-48111	CD	denotes	20
T25512	48112-48114	IN	denotes	in
T25513	48115-48118	NN	denotes	PBS
T25514	48118-48119	-RRB-	denotes	)
T25515	48120-48123	CC	denotes	and
T25516	48124-48134	VBN	denotes	autoclaved
T25517	48135-48137	IN	denotes	in
T25518	48138-48140	CD	denotes	10
T25520	48151-48155	NN	denotes	acid
T25521	48144-48150	JJ	denotes	citric
T25522	48156-48157	-LRB-	denotes	(
T25523	48157-48159	NN	denotes	pH
T25524	48160-48163	CD	denotes	6.0
T25525	48163-48164	-RRB-	denotes	)
T25526	48165-48167	TO	denotes	to
T25527	48168-48176	VB	denotes	retrieve
T25528	48177-48189	NN	denotes	antigenicity
T25529	48189-48190	.	denotes	.
T25530	48190-48410	sentence	denotes	Slides were blocked in 5% serum (matched to the species of the secondary antibody) in PBS for 1 h at room temperature and incubated with primary antibodies overnight at 4 °C prior to detection with secondary antibodies.
T25531	48191-48197	NNS	denotes	Slides
T25532	48203-48210	VBN	denotes	blocked
T25533	48198-48202	VBD	denotes	were
T25534	48211-48213	IN	denotes	in
T25535	48214-48215	CD	denotes	5
T25536	48215-48216	NN	denotes	%
T25537	48217-48222	NN	denotes	serum
T25538	48223-48224	-LRB-	denotes	(
T25539	48224-48231	VBN	denotes	matched
T25540	48232-48234	IN	denotes	to
T25541	48235-48238	DT	denotes	the
T25542	48239-48246	NNS	denotes	species
T25543	48247-48249	IN	denotes	of
T25544	48250-48253	DT	denotes	the
T25545	48264-48272	NN	denotes	antibody
T25546	48254-48263	JJ	denotes	secondary
T25547	48272-48273	-RRB-	denotes	)
T25548	48274-48276	IN	denotes	in
T25549	48277-48280	NN	denotes	PBS
T25550	48281-48284	IN	denotes	for
T25551	48285-48286	CD	denotes	1
T25552	48287-48288	NN	denotes	h
T25553	48289-48291	IN	denotes	at
T25554	48292-48296	NN	denotes	room
T25555	48297-48308	NN	denotes	temperature
T25556	48309-48312	CC	denotes	and
T25557	48313-48322	VBN	denotes	incubated
T25558	48323-48327	IN	denotes	with
T25559	48328-48335	JJ	denotes	primary
T25560	48336-48346	NNS	denotes	antibodies
T25561	48347-48356	RB	denotes	overnight
T25562	48357-48359	IN	denotes	at
T25563	48360-48361	CD	denotes	4
T25564	48362-48364	NN	denotes	°C
T25565	48365-48370	IN	denotes	prior
T25566	48371-48373	IN	denotes	to
T25567	48374-48383	NN	denotes	detection
T25568	48384-48388	IN	denotes	with
T25569	48389-48398	JJ	denotes	secondary
T25570	48399-48409	NNS	denotes	antibodies
T25571	48409-48410	.	denotes	.
T26486	48412-48422	NNS	denotes	Antibodies
T26487	48422-48423	.	denotes	.
T26488	48423-48600	sentence	denotes	Rabbit polyclonal antibodies to DMRT7 were raised against a purified fusion protein containing glutathione-S-transferase (GST) fused to the C-terminal 279 amino acids of DMRT7.
T26489	48424-48430	NN	denotes	Rabbit
T26490	48442-48452	NNS	denotes	antibodies
T26491	48431-48441	JJ	denotes	polyclonal
T26492	48467-48473	VBN	denotes	raised
T26493	48453-48455	IN	denotes	to
T26494	48456-48461	NN	denotes	DMRT7
T26495	48462-48466	VBD	denotes	were
T26496	48474-48481	IN	denotes	against
T26497	48482-48483	DT	denotes	a
T26498	48500-48507	NN	denotes	protein
T26499	48484-48492	VBN	denotes	purified
T26500	48493-48499	NN	denotes	fusion
T26501	48508-48518	VBG	denotes	containing
T26502	48519-48530	NN	denotes	glutathione
T26503	48533-48544	NN	denotes	transferase
T26504	48530-48531	HYPH	denotes	-
T26505	48531-48532	NN	denotes	S
T26506	48532-48533	HYPH	denotes	-
T26507	48545-48546	-LRB-	denotes	(
T26508	48546-48549	NN	denotes	GST
T26509	48549-48550	-RRB-	denotes	)
T26510	48551-48556	VBN	denotes	fused
T26511	48557-48559	IN	denotes	to
T26512	48560-48563	DT	denotes	the
T26513	48585-48590	NNS	denotes	acids
T26514	48564-48565	NN	denotes	C
T26515	48566-48574	JJ	denotes	terminal
T26516	48565-48566	HYPH	denotes	-
T26517	48575-48578	CD	denotes	279
T26518	48579-48584	NN	denotes	amino
T26519	48591-48593	IN	denotes	of
T26520	48594-48599	NN	denotes	DMRT7
T26521	48599-48600	.	denotes	.
T26522	48600-48740	sentence	denotes	Antibodies to GST were removed by GST-affigel 10 chromatography and the antiserum was then purified by GST-DMRT7-affigel 15 chromatography.
T26523	48601-48611	NNS	denotes	Antibodies
T26524	48624-48631	VBN	denotes	removed
T26525	48612-48614	IN	denotes	to
T26526	48615-48618	NN	denotes	GST
T26527	48619-48623	VBD	denotes	were
T26528	48632-48634	IN	denotes	by
T26529	48635-48638	NN	denotes	GST
T26530	48639-48646	NN	denotes	affigel
T26531	48638-48639	HYPH	denotes	-
T26532	48650-48664	NN	denotes	chromatography
T26533	48647-48649	CD	denotes	10
T26534	48665-48668	CC	denotes	and
T26535	48669-48672	DT	denotes	the
T26536	48673-48682	NN	denotes	antiserum
T26537	48692-48700	VBN	denotes	purified
T26538	48683-48686	VBD	denotes	was
T26539	48687-48691	RB	denotes	then
T26540	48701-48703	IN	denotes	by
T26541	48704-48707	NN	denotes	GST
T26542	48708-48713	NN	denotes	DMRT7
T26543	48707-48708	HYPH	denotes	-
T26544	48714-48721	NN	denotes	affigel
T26545	48713-48714	HYPH	denotes	-
T26546	48725-48739	NN	denotes	chromatography
T26547	48722-48724	CD	denotes	15
T26548	48739-48740	.	denotes	.
T26549	48740-48890	sentence	denotes	DMRT7 antibody was used at 1:200 dilution with a goat anti-rabbit secondary antibody (Molecular Probes, http://www.invitrogen.com) at 1:200 dilution.
T26550	48741-48746	NN	denotes	DMRT7
T26551	48747-48755	NN	denotes	antibody
T26552	48760-48764	VBN	denotes	used
T26553	48756-48759	VBD	denotes	was
T26554	48765-48767	IN	denotes	at
T26555	48768-48769	CD	denotes	1
T26556	48774-48782	NN	denotes	dilution
T26557	48769-48770	SYM	denotes	:
T26558	48770-48773	CD	denotes	200
T26559	48783-48787	IN	denotes	with
T26560	48788-48789	DT	denotes	a
T26561	48817-48825	NN	denotes	antibody
T26562	48790-48794	NN	denotes	goat
T26563	48795-48806	JJ	denotes	anti-rabbit
T26564	48807-48816	JJ	denotes	secondary
T26565	48826-48827	-LRB-	denotes	(
T26566	48837-48843	NNP	denotes	Probes
T26567	48827-48836	NNP	denotes	Molecular
T26568	48843-48845	,	denotes	,
T26569	48845-48870	NN	denotes	http://www.invitrogen.com
T26570	48870-48871	-RRB-	denotes	)
T26571	48872-48874	IN	denotes	at
T26572	48875-48876	CD	denotes	1
T26573	48881-48889	NN	denotes	dilution
T26574	48876-48877	SYM	denotes	:
T26575	48877-48880	CD	denotes	200
T26576	48889-48890	.	denotes	.
T26577	48890-49892	sentence	denotes	Other primary antibodies used for immunofluorescence were rat anti-GATA1 (1:200, Santa Cruz Biotechnology, http://www.scbt.com, sc-265), goat anti-GATA4 (1:200, Santa Cruz Biotechnology, sc-1237), rat anti-TRA98 (1:200, gift of H. Tanaka and Y. Nishimune), rat anti-BC7 (1:50, gift of H. Tanaka and Y. Nishimune), rat anti-TRA369 (1:200, gift of H. Tanaka and Y. Nishimune), rabbit anti-RAD51 (1:600 Calbiochem, http://www.calbiochem.com, PC130), mouse anti-GMP-1/SUMO-1 (1:200, Zymed, http://invitrogen.com, 33–2400), rabbit anti-phospho-H2AX (Ser139) (1:200, Upstate, http://www.millipore.com, 01–164), mouse anti-phospho-H2AX (1:200, Upstate, 05–636), mouse anti-SYCP3 (1:200, Abcam, http://www.abcam.com, ab12452), rabbit anti-HP1β (1:100, Abcam, ab10478), rabbit anti-H3-2meK9 (1:100, Upstate, 07–441), rabbit anti-H3-3meK9 (1:200, Upstate, 07–442), rabbit anti-AR (N-20) (1:200, Santa Cruz Biotechnology, sc-816), and mouse anti-αSMA clone 1A4 (1:800, Sigma, http://www.sigmaaldrich.com, A2547).
T26578	48891-48896	JJ	denotes	Other
T26579	48905-48915	NNS	denotes	antibodies
T26580	48897-48904	JJ	denotes	primary
T26581	48944-48948	VBD	denotes	were
T26582	48916-48920	VBN	denotes	used
T26583	48921-48924	IN	denotes	for
T26584	48925-48943	NN	denotes	immunofluorescence
T26585	48949-48952	NN	denotes	rat
T26586	48953-48963	JJ	denotes	anti-GATA1
T26587	48964-48965	-LRB-	denotes	(
T26588	49022-49025	NN	denotes	265
T26589	48965-48966	CD	denotes	1
T26590	48966-48967	SYM	denotes	:
T26591	48967-48970	CD	denotes	200
T26592	48970-48972	,	denotes	,
T26593	48972-48977	NNP	denotes	Santa
T26594	48978-48982	NNP	denotes	Cruz
T26595	48983-48996	NNP	denotes	Biotechnology
T26596	48996-48998	,	denotes	,
T26597	48998-49017	NN	denotes	http://www.scbt.com
T26598	49017-49019	,	denotes	,
T26599	49019-49021	NN	denotes	sc
T26600	49021-49022	HYPH	denotes	-
T26601	49025-49026	-RRB-	denotes	)
T26602	49026-49028	,	denotes	,
T26603	49028-49032	NN	denotes	goat
T26604	49033-49043	JJ	denotes	anti-GATA4
T26605	49044-49045	-LRB-	denotes	(
T26606	49078-49080	NN	denotes	sc
T26607	49045-49046	CD	denotes	1
T26608	49046-49047	SYM	denotes	:
T26609	49047-49050	CD	denotes	200
T26610	49050-49052	,	denotes	,
T26611	49052-49057	NNP	denotes	Santa
T26612	49058-49062	NNP	denotes	Cruz
T26613	49063-49076	NNP	denotes	Biotechnology
T26614	49076-49078	,	denotes	,
T26615	49080-49081	HYPH	denotes	-
T26616	49081-49085	CD	denotes	1237
T26617	49085-49086	-RRB-	denotes	)
T26618	49086-49088	,	denotes	,
T26619	49088-49091	NN	denotes	rat
T26620	49092-49102	JJ	denotes	anti-TRA98
T26621	49103-49104	-LRB-	denotes	(
T26622	49111-49115	NN	denotes	gift
T26623	49104-49105	CD	denotes	1
T26624	49105-49106	SYM	denotes	:
T26625	49106-49109	CD	denotes	200
T26626	49109-49111	,	denotes	,
T26627	49116-49118	IN	denotes	of
T26628	49119-49121	NNP	denotes	H.
T26629	49122-49128	NNP	denotes	Tanaka
T26630	49129-49132	CC	denotes	and
T26631	49133-49135	NNP	denotes	Y.
T26632	49136-49145	NNP	denotes	Nishimune
T26633	49145-49146	-RRB-	denotes	)
T26634	49146-49148	,	denotes	,
T26635	49148-49151	NN	denotes	rat
T26636	49152-49160	JJ	denotes	anti-BC7
T26637	49161-49162	-LRB-	denotes	(
T26638	49168-49172	NN	denotes	gift
T26639	49162-49163	CD	denotes	1
T26640	49163-49164	SYM	denotes	:
T26641	49164-49166	CD	denotes	50
T26642	49166-49168	,	denotes	,
T26643	49173-49175	IN	denotes	of
T26644	49176-49178	NNP	denotes	H.
T26645	49179-49185	NNP	denotes	Tanaka
T26646	49186-49189	CC	denotes	and
T26647	49190-49192	NNP	denotes	Y.
T26648	49193-49202	NNP	denotes	Nishimune
T26649	49202-49203	-RRB-	denotes	)
T26650	49203-49205	,	denotes	,
T26651	49205-49208	NN	denotes	rat
T26652	49209-49220	JJ	denotes	anti-TRA369
T26653	49221-49222	-LRB-	denotes	(
T26654	49229-49233	NN	denotes	gift
T26655	49222-49223	CD	denotes	1
T26656	49223-49224	SYM	denotes	:
T26657	49224-49227	CD	denotes	200
T26658	49227-49229	,	denotes	,
T26659	49234-49236	IN	denotes	of
T26660	49237-49239	NNP	denotes	H.
T26661	49240-49246	NNP	denotes	Tanaka
T26662	49247-49250	CC	denotes	and
T26663	49251-49253	NNP	denotes	Y.
T26664	49254-49263	NNP	denotes	Nishimune
T26665	49263-49264	-RRB-	denotes	)
T26666	49264-49266	,	denotes	,
T26667	49266-49272	NN	denotes	rabbit
T26668	49273-49283	JJ	denotes	anti-RAD51
T26669	49284-49285	-LRB-	denotes	(
T26670	49330-49335	NN	denotes	PC130
T26671	49285-49286	CD	denotes	1
T26672	49286-49287	SYM	denotes	:
T26673	49287-49290	CD	denotes	600
T26674	49291-49301	NNP	denotes	Calbiochem
T26675	49301-49303	,	denotes	,
T26676	49303-49328	NN	denotes	http://www.calbiochem.com
T26677	49328-49330	,	denotes	,
T26678	49335-49336	-RRB-	denotes	)
T26679	49336-49338	,	denotes	,
T26680	49338-49343	NN	denotes	mouse
T26681	49355-49359	NN	denotes	SUMO
T26682	49344-49352	JJ	denotes	anti-GMP
T26683	49352-49353	HYPH	denotes	-
T26684	49353-49354	CD	denotes	1
T26685	49354-49355	HYPH	denotes	/
T26686	49359-49360	HYPH	denotes	-
T26687	49360-49361	CD	denotes	1
T26688	49362-49363	-LRB-	denotes	(
T26689	49400-49402	CD	denotes	33
T26690	49363-49364	CD	denotes	1
T26691	49364-49365	SYM	denotes	:
T26692	49365-49368	CD	denotes	200
T26693	49368-49370	,	denotes	,
T26694	49370-49375	NNP	denotes	Zymed
T26695	49375-49377	,	denotes	,
T26696	49377-49398	NN	denotes	http://invitrogen.com
T26697	49398-49400	,	denotes	,
T26698	49402-49403	SYM	denotes	–
T26699	49403-49407	CD	denotes	2400
T26700	49407-49408	-RRB-	denotes	)
T26701	49408-49410	,	denotes	,
T26702	49410-49416	NN	denotes	rabbit
T26703	49430-49434	NN	denotes	H2AX
T26704	49417-49429	JJ	denotes	anti-phospho
T26705	49429-49430	HYPH	denotes	-
T26706	49435-49436	-LRB-	denotes	(
T26707	49436-49442	NN	denotes	Ser139
T26708	49442-49443	-RRB-	denotes	)
T26709	49444-49445	-LRB-	denotes	(
T26710	49487-49489	CD	denotes	01
T26711	49445-49446	CD	denotes	1
T26712	49446-49447	SYM	denotes	:
T26713	49447-49450	CD	denotes	200
T26714	49450-49452	,	denotes	,
T26715	49452-49459	NNP	denotes	Upstate
T26716	49459-49461	,	denotes	,
T26717	49461-49485	NN	denotes	http://www.millipore.com
T26718	49485-49487	,	denotes	,
T26719	49489-49490	SYM	denotes	–
T26720	49490-49493	CD	denotes	164
T26721	49493-49494	-RRB-	denotes	)
T26722	49494-49496	,	denotes	,
T26723	49496-49501	NN	denotes	mouse
T26724	49515-49519	NN	denotes	H2AX
T26725	49502-49514	JJ	denotes	anti-phospho
T26726	49514-49515	HYPH	denotes	-
T26727	49520-49521	-LRB-	denotes	(
T26728	49537-49539	CD	denotes	05
T26729	49521-49522	CD	denotes	1
T26730	49522-49523	SYM	denotes	:
T26731	49523-49526	CD	denotes	200
T26732	49526-49528	,	denotes	,
T26733	49528-49535	NNP	denotes	Upstate
T26734	49535-49537	,	denotes	,
T26735	49539-49540	SYM	denotes	–
T26736	49540-49543	CD	denotes	636
T26737	49543-49544	-RRB-	denotes	)
T26738	49544-49546	,	denotes	,
T26739	49546-49551	NN	denotes	mouse
T26740	49552-49562	JJ	denotes	anti-SYCP3
T26741	49563-49564	-LRB-	denotes	(
T26742	49600-49607	NN	denotes	ab12452
T26743	49564-49565	CD	denotes	1
T26744	49565-49566	SYM	denotes	:
T26745	49566-49569	CD	denotes	200
T26746	49569-49571	,	denotes	,
T26747	49571-49576	NNP	denotes	Abcam
T26748	49576-49578	,	denotes	,
T26749	49578-49598	NN	denotes	http://www.abcam.com
T26750	49598-49600	,	denotes	,
T26751	49607-49608	-RRB-	denotes	)
T26752	49608-49610	,	denotes	,
T26753	49610-49616	NN	denotes	rabbit
T26754	49617-49626	JJ	denotes	anti-HP1β
T26755	49627-49628	-LRB-	denotes	(
T26756	49642-49649	NN	denotes	ab10478
T26757	49628-49629	CD	denotes	1
T26758	49629-49630	SYM	denotes	:
T26759	49630-49633	CD	denotes	100
T26760	49633-49635	,	denotes	,
T26761	49635-49640	NNP	denotes	Abcam
T26762	49640-49642	,	denotes	,
T26763	49649-49650	-RRB-	denotes	)
T26764	49650-49652	,	denotes	,
T26765	49652-49658	NN	denotes	rabbit
T26766	49667-49672	NN	denotes	2meK9
T26767	49659-49666	JJ	denotes	anti-H3
T26768	49666-49667	HYPH	denotes	-
T26769	49673-49674	-LRB-	denotes	(
T26770	49690-49692	CD	denotes	07
T26771	49674-49675	CD	denotes	1
T26772	49675-49676	SYM	denotes	:
T26773	49676-49679	CD	denotes	100
T26774	49679-49681	,	denotes	,
T26775	49681-49688	NNP	denotes	Upstate
T26776	49688-49690	,	denotes	,
T26777	49692-49693	SYM	denotes	–
T26778	49693-49696	CD	denotes	441
T26779	49696-49697	-RRB-	denotes	)
T26780	49697-49699	,	denotes	,
T26781	49699-49705	NN	denotes	rabbit
T26782	49714-49719	NN	denotes	3meK9
T26783	49706-49713	JJ	denotes	anti-H3
T26784	49713-49714	HYPH	denotes	-
T26785	49720-49721	-LRB-	denotes	(
T26786	49737-49739	CD	denotes	07
T26787	49721-49722	CD	denotes	1
T26788	49722-49723	SYM	denotes	:
T26789	49723-49726	CD	denotes	200
T26790	49726-49728	,	denotes	,
T26791	49728-49735	NNP	denotes	Upstate
T26792	49735-49737	,	denotes	,
T26793	49739-49740	SYM	denotes	–
T26794	49740-49743	CD	denotes	442
T26795	49743-49744	-RRB-	denotes	)
T26796	49744-49746	,	denotes	,
T26797	49746-49752	NN	denotes	rabbit
T26798	49753-49760	JJ	denotes	anti-AR
T26799	49761-49762	-LRB-	denotes	(
T26800	49762-49763	NN	denotes	N
T26801	49763-49764	HYPH	denotes	-
T26802	49764-49766	CD	denotes	20
T26803	49766-49767	-RRB-	denotes	)
T26804	49768-49769	-LRB-	denotes	(
T26805	49802-49804	NN	denotes	sc
T26806	49769-49770	CD	denotes	1
T26807	49770-49771	SYM	denotes	:
T26808	49771-49774	CD	denotes	200
T26809	49774-49776	,	denotes	,
T26810	49776-49781	NNP	denotes	Santa
T26811	49782-49786	NNP	denotes	Cruz
T26812	49787-49800	NNP	denotes	Biotechnology
T26813	49800-49802	,	denotes	,
T26814	49804-49805	HYPH	denotes	-
T26815	49805-49808	CD	denotes	816
T26816	49808-49809	-RRB-	denotes	)
T26817	49809-49811	,	denotes	,
T26818	49811-49814	CC	denotes	and
T26819	49815-49820	NN	denotes	mouse
T26820	49837-49840	NN	denotes	1A4
T26821	49821-49830	JJ	denotes	anti-αSMA
T26822	49831-49836	NN	denotes	clone
T26823	49841-49842	-LRB-	denotes	(
T26824	49885-49890	NN	denotes	A2547
T26825	49842-49843	CD	denotes	1
T26826	49843-49844	SYM	denotes	:
T26827	49844-49847	CD	denotes	800
T26828	49847-49849	,	denotes	,
T26829	49849-49854	NNP	denotes	Sigma
T26830	49854-49856	,	denotes	,
T26831	49856-49883	NN	denotes	http://www.sigmaaldrich.com
T26832	49883-49885	,	denotes	,
T26833	49890-49891	-RRB-	denotes	)
T26834	49891-49892	.	denotes	.
T26835	49892-50068	sentence	denotes	Secondary antibodies used were goat anti-rabbit Alexa 488, goat anti-rabbit Alexa 594, goat anti-rat Alexa 594, and goat anti-mouse Alexa 488 (Molecular Probes) used at 1:250.
T26836	49893-49902	JJ	denotes	Secondary
T26837	49903-49913	NNS	denotes	antibodies
T26838	49919-49923	VBD	denotes	were
T26839	49914-49918	VBN	denotes	used
T26840	49924-49928	NN	denotes	goat
T26841	49941-49946	NNP	denotes	Alexa
T26842	49929-49940	JJ	denotes	anti-rabbit
T26843	49947-49950	CD	denotes	488
T26844	49950-49952	,	denotes	,
T26845	49952-49956	NN	denotes	goat
T26846	49969-49974	NNP	denotes	Alexa
T26847	49957-49968	JJ	denotes	anti-rabbit
T26848	49975-49978	CD	denotes	594
T26849	49978-49980	,	denotes	,
T26850	49980-49984	NN	denotes	goat
T26851	49994-49999	NNP	denotes	Alexa
T26852	49985-49993	JJ	denotes	anti-rat
T26853	50000-50003	CD	denotes	594
T26854	50003-50005	,	denotes	,
T26855	50005-50008	CC	denotes	and
T26856	50009-50013	NN	denotes	goat
T26857	50025-50030	NNP	denotes	Alexa
T26858	50014-50024	JJ	denotes	anti-mouse
T26859	50031-50034	CD	denotes	488
T26860	50035-50036	-LRB-	denotes	(
T26861	50046-50052	NNP	denotes	Probes
T26862	50036-50045	NNP	denotes	Molecular
T26863	50052-50053	-RRB-	denotes	)
T26864	50054-50058	VBN	denotes	used
T26865	50059-50061	IN	denotes	at
T26866	50062-50063	CD	denotes	1
T26867	50063-50064	SYM	denotes	:
T26868	50064-50067	CD	denotes	250
T26869	50067-50068	.	denotes	.
T26870	50068-50265	sentence	denotes	Donkey anti-goat FITC (Jackson ImmunoResearch Laboratories, http://www.jacksonimmuno.com) and donkey anti-rabbit Texas Red (Jackson) were used at 1:50 according to the manufacturer's instructions.
T26871	50069-50075	NN	denotes	Donkey
T26872	50086-50090	NN	denotes	FITC
T26873	50076-50085	JJ	denotes	anti-goat
T26874	50207-50211	VBN	denotes	used
T26875	50091-50092	-LRB-	denotes	(
T26876	50115-50127	NNP	denotes	Laboratories
T26877	50092-50099	NNP	denotes	Jackson
T26878	50100-50114	NNP	denotes	ImmunoResearch
T26879	50127-50129	,	denotes	,
T26880	50129-50157	NN	denotes	http://www.jacksonimmuno.com
T26881	50157-50158	-RRB-	denotes	)
T26882	50159-50162	CC	denotes	and
T26883	50163-50169	NN	denotes	donkey
T26884	50188-50191	NN	denotes	Red
T26885	50170-50181	JJ	denotes	anti-rabbit
T26886	50182-50187	NN	denotes	Texas
T26887	50192-50193	-LRB-	denotes	(
T26888	50193-50200	NNP	denotes	Jackson
T26889	50200-50201	-RRB-	denotes	)
T26890	50202-50206	VBD	denotes	were
T26891	50212-50214	IN	denotes	at
T26892	50215-50216	CD	denotes	1
T26893	50216-50217	SYM	denotes	:
T26894	50217-50219	CD	denotes	50
T26895	50220-50229	VBG	denotes	according
T26896	50230-50232	IN	denotes	to
T26897	50233-50236	DT	denotes	the
T26898	50237-50249	NN	denotes	manufacturer
T26899	50252-50264	NNS	denotes	instructions
T26900	50249-50251	POS	denotes	's
T26901	50264-50265	.	denotes	.
T27238	50540-50550	VBG	denotes	containing
T27179	50267-50274	JJ	denotes	Meiotic
T27180	50275-50285	NN	denotes	chromosome
T27181	50293-50305	NNS	denotes	preparations
T27182	50286-50292	NN	denotes	spread
T27183	50306-50309	CC	denotes	and
T27184	50310-50314	NN	denotes	FISH
T27185	50314-50315	.	denotes	.
T27186	50315-50432	sentence	denotes	Meiotic chromosome spread preparations were made from 3-wk-old mice, prepared as described by Reinholdt et al. [63].
T27187	50316-50323	JJ	denotes	Meiotic
T27188	50324-50334	NN	denotes	chromosome
T27189	50342-50354	NNS	denotes	preparations
T27190	50335-50341	NN	denotes	spread
T27191	50360-50364	VBN	denotes	made
T27192	50355-50359	VBD	denotes	were
T27193	50365-50369	IN	denotes	from
T27194	50370-50371	CD	denotes	3
T27195	50372-50374	NN	denotes	wk
T27196	50371-50372	HYPH	denotes	-
T27197	50375-50378	JJ	denotes	old
T27198	50374-50375	HYPH	denotes	-
T27199	50379-50383	NNS	denotes	mice
T27200	50383-50385	,	denotes	,
T27201	50385-50393	VBN	denotes	prepared
T27202	50394-50396	IN	denotes	as
T27203	50397-50406	VBN	denotes	described
T27204	50407-50409	IN	denotes	by
T27205	50410-50419	NNP	denotes	Reinholdt
T27206	50420-50422	FW	denotes	et
T27207	50423-50426	FW	denotes	al.
T27208	50427-50428	-LRB-	denotes	[
T27209	50428-50430	CD	denotes	63
T27210	50430-50431	-RRB-	denotes	]
T27211	50431-50432	.	denotes	.
T27212	50432-50532	sentence	denotes	For analysis of PMSC and Cot-1 RNA FISH, meiotic slides were prepared as previously described [16].
T27213	50433-50436	IN	denotes	For
T27214	50494-50502	VBN	denotes	prepared
T27215	50437-50445	NN	denotes	analysis
T27216	50446-50448	IN	denotes	of
T27217	50449-50453	NN	denotes	PMSC
T27218	50454-50457	CC	denotes	and
T27219	50458-50461	NN	denotes	Cot
T27220	50468-50472	NN	denotes	FISH
T27221	50461-50462	HYPH	denotes	-
T27222	50462-50463	CD	denotes	1
T27223	50464-50467	NN	denotes	RNA
T27224	50472-50474	,	denotes	,
T27225	50474-50481	JJ	denotes	meiotic
T27226	50482-50488	NNS	denotes	slides
T27227	50489-50493	VBD	denotes	were
T27228	50503-50505	IN	denotes	as
T27229	50517-50526	VBN	denotes	described
T27230	50506-50516	RB	denotes	previously
T27231	50527-50528	-LRB-	denotes	[
T27232	50528-50530	CD	denotes	16
T27233	50530-50531	-RRB-	denotes	]
T27234	50531-50532	.	denotes	.
T27235	50532-50685	sentence	denotes	Slides containing chromosome spreads or meiotic spermatocytes were subjected to immunofluorescent staining or RNA FISH, as previously described [16,63].
T27236	50533-50539	NNS	denotes	Slides
T27237	50600-50609	VBN	denotes	subjected
T27239	50551-50561	NN	denotes	chromosome
T27240	50562-50569	NNS	denotes	spreads
T27241	50570-50572	CC	denotes	or
T27242	50573-50580	JJ	denotes	meiotic
T27243	50581-50594	NNS	denotes	spermatocytes
T27244	50595-50599	VBD	denotes	were
T27245	50610-50612	IN	denotes	to
T27246	50613-50630	JJ	denotes	immunofluorescent
T27247	50631-50639	NN	denotes	staining
T27248	50640-50642	CC	denotes	or
T27249	50643-50646	NN	denotes	RNA
T27250	50647-50651	NN	denotes	FISH
T27251	50651-50653	,	denotes	,
T27252	50653-50655	IN	denotes	as
T27253	50667-50676	VBN	denotes	described
T27254	50656-50666	RB	denotes	previously
T27255	50677-50678	-LRB-	denotes	[
T27256	50681-50683	CD	denotes	63
T27257	50678-50680	CD	denotes	16
T27258	50680-50681	,	denotes	,
T27259	50683-50684	-RRB-	denotes	]
T27260	50684-50685	.	denotes	.
T27261	50685-50786	sentence	denotes	For combined RNA FISH/immunostaining, we carried out RNA FISH first, followed by immunofluorescence.
T27262	50686-50689	IN	denotes	For
T27263	50727-50734	VBD	denotes	carried
T27264	50690-50698	VBN	denotes	combined
T27265	50703-50707	NN	denotes	FISH
T27266	50699-50702	NN	denotes	RNA
T27267	50707-50708	HYPH	denotes	/
T27268	50708-50722	NN	denotes	immunostaining
T27269	50722-50724	,	denotes	,
T27270	50724-50726	PRP	denotes	we
T27271	50735-50738	RP	denotes	out
T27272	50739-50742	NN	denotes	RNA
T27273	50743-50747	NN	denotes	FISH
T27274	50748-50753	RB	denotes	first
T27275	50753-50755	,	denotes	,
T27276	50755-50763	VBN	denotes	followed
T27277	50764-50766	IN	denotes	by
T27278	50767-50785	NN	denotes	immunofluorescence
T27279	50785-50786	.	denotes	.
T27280	50786-50870	sentence	denotes	DNA FISH was performed using chromosome painting (Cambio, http://www.cambio.co.uk).
T27281	50787-50790	NN	denotes	DNA
T27282	50791-50795	NN	denotes	FISH
T27283	50800-50809	VBN	denotes	performed
T27284	50796-50799	VBD	denotes	was
T27285	50810-50815	VBG	denotes	using
T27286	50816-50826	NN	denotes	chromosome
T27287	50827-50835	NN	denotes	painting
T27288	50836-50837	-LRB-	denotes	(
T27289	50837-50843	NNP	denotes	Cambio
T27290	50843-50845	,	denotes	,
T27291	50845-50868	NN	denotes	http://www.cambio.co.uk
T27292	50868-50869	-RRB-	denotes	)
T27293	50869-50870	.	denotes	.
T27294	50870-51022	sentence	denotes	Z-sections were captured by Zeiss Axioplan microscope (Zeiss, http://www.zeiss.com) and processed by Openlab (Improvision, http://www.improvision.com).
T27295	50871-50872	NN	denotes	Z
T27296	50873-50881	NNS	denotes	sections
T27297	50872-50873	HYPH	denotes	-
T27298	50887-50895	VBN	denotes	captured
T27299	50882-50886	VBD	denotes	were
T27300	50896-50898	IN	denotes	by
T27301	50899-50904	NNP	denotes	Zeiss
T27302	50914-50924	NN	denotes	microscope
T27303	50905-50913	NNP	denotes	Axioplan
T27304	50925-50926	-LRB-	denotes	(
T27305	50926-50931	NNP	denotes	Zeiss
T27306	50931-50933	,	denotes	,
T27307	50933-50953	NN	denotes	http://www.zeiss.com
T27308	50953-50954	-RRB-	denotes	)
T27309	50955-50958	CC	denotes	and
T27310	50959-50968	VBN	denotes	processed
T27311	50969-50971	IN	denotes	by
T27312	50972-50979	NNP	denotes	Openlab
T27313	50980-50981	-LRB-	denotes	(
T27314	50981-50992	NNP	denotes	Improvision
T27315	50992-50994	,	denotes	,
T27316	50994-51020	NN	denotes	http://www.improvision.com
T27317	51020-51021	-RRB-	denotes	)
T27318	51021-51022	.	denotes	.
T27803	10737-10738	-LRB-	denotes	(
T27759	10545-10555	NN	denotes	Expression
T27760	10556-10558	IN	denotes	of
T27761	10559-10564	NN	denotes	Dmrt7
T27762	10565-10569	NN	denotes	mRNA
T27763	10570-10573	CC	denotes	and
T27764	10574-10581	NN	denotes	Protein
T27765	10581-10647	sentence	denotes	(A) RT-PCR analysis of Dmrt7 mRNA from ten organs of adult mouse.
T27766	10582-10583	-LRB-	denotes	(
T27767	10583-10584	LS	denotes	A
T27768	10593-10601	NN	denotes	analysis
T27769	10584-10585	-RRB-	denotes	)
T27770	10586-10588	NN	denotes	RT
T27771	10589-10592	NN	denotes	PCR
T27772	10588-10589	HYPH	denotes	-
T27773	10602-10604	IN	denotes	of
T27774	10605-10610	NN	denotes	Dmrt7
T27775	10611-10615	NN	denotes	mRNA
T27776	10616-10620	IN	denotes	from
T27777	10621-10624	CD	denotes	ten
T27778	10625-10631	NNS	denotes	organs
T27779	10632-10634	IN	denotes	of
T27780	10635-10640	JJ	denotes	adult
T27781	10641-10646	NN	denotes	mouse
T27782	10646-10647	.	denotes	.
T27783	10647-10750	sentence	denotes	cDNA from each organ was amplified with primers specific for Dmrt7 (top row) and β-actin (bottom row).
T27784	10648-10652	NN	denotes	cDNA
T27785	10673-10682	VBN	denotes	amplified
T27786	10653-10657	IN	denotes	from
T27787	10658-10662	DT	denotes	each
T27788	10663-10668	NN	denotes	organ
T27789	10669-10672	VBD	denotes	was
T27790	10683-10687	IN	denotes	with
T27791	10688-10695	NNS	denotes	primers
T27792	10696-10704	JJ	denotes	specific
T27793	10705-10708	IN	denotes	for
T27794	10709-10714	NN	denotes	Dmrt7
T27795	10715-10716	-LRB-	denotes	(
T27796	10720-10723	NN	denotes	row
T27797	10716-10719	JJ	denotes	top
T27798	10723-10724	-RRB-	denotes	)
T27799	10725-10728	CC	denotes	and
T27800	10729-10730	NN	denotes	β
T27801	10731-10736	NN	denotes	actin
T27802	10730-10731	HYPH	denotes	-
T27804	10745-10748	NN	denotes	row
T27805	10738-10744	JJ	denotes	bottom
T27806	10748-10749	-RRB-	denotes	)
T27807	10749-10750	.	denotes	.
T27808	10750-10819	sentence	denotes	(B) Dmrt7 mRNA expression during the first round of spermatogenesis.
T27809	10751-10752	-LRB-	denotes	(
T27810	10752-10753	LS	denotes	B
T27811	10766-10776	NN	denotes	expression
T27812	10753-10754	-RRB-	denotes	)
T27813	10755-10760	NN	denotes	Dmrt7
T27814	10761-10765	NN	denotes	mRNA
T27815	10777-10783	IN	denotes	during
T27816	10784-10787	DT	denotes	the
T27817	10794-10799	NN	denotes	round
T27818	10788-10793	JJ	denotes	first
T27819	10800-10802	IN	denotes	of
T27820	10803-10818	NN	denotes	spermatogenesis
T27821	10818-10819	.	denotes	.
T27822	10819-10906	sentence	denotes	cDNAs obtained from testis at the indicated days after birth were amplified as in (A).
T27823	10820-10825	NNS	denotes	cDNAs
T27824	10886-10895	VBN	denotes	amplified
T27825	10826-10834	VBN	denotes	obtained
T27826	10835-10839	IN	denotes	from
T27827	10840-10846	NN	denotes	testis
T27828	10847-10849	IN	denotes	at
T27829	10850-10853	DT	denotes	the
T27830	10864-10868	NNS	denotes	days
T27831	10854-10863	VBN	denotes	indicated
T27832	10869-10874	IN	denotes	after
T27833	10875-10880	NN	denotes	birth
T27834	10881-10885	VBD	denotes	were
T27835	10896-10898	IN	denotes	as
T27836	10899-10901	IN	denotes	in
T27837	10902-10903	-LRB-	denotes	(
T27838	10903-10904	NN	denotes	A
T27839	10904-10905	-RRB-	denotes	)
T27840	10905-10906	.	denotes	.
T27841	10906-10936	sentence	denotes	(C) DMRT7 protein expression.
T27842	10907-10908	-LRB-	denotes	(
T27843	10908-10909	LS	denotes	C
T27844	10925-10935	NN	denotes	expression
T27845	10909-10910	-RRB-	denotes	)
T27846	10911-10916	NN	denotes	DMRT7
T27847	10917-10924	NN	denotes	protein
T27848	10935-10936	.	denotes	.
T27849	10936-11049	sentence	denotes	Immunofluorescence of testis sections from 6-wk-old male stained with antibody to DMRT7 (green) and DAPI (blue).
T27850	10937-10955	NN	denotes	Immunofluorescence
T27851	10956-10958	IN	denotes	of
T27852	10959-10965	NN	denotes	testis
T27853	10966-10974	NNS	denotes	sections
T27854	10975-10979	IN	denotes	from
T27855	10980-10981	CD	denotes	6
T27856	10982-10984	NN	denotes	wk
T27857	10981-10982	HYPH	denotes	-
T27858	10985-10988	JJ	denotes	old
T27859	10984-10985	HYPH	denotes	-
T27860	10989-10993	JJ	denotes	male
T27861	10994-11001	VBN	denotes	stained
T27862	11002-11006	IN	denotes	with
T27863	11007-11015	NN	denotes	antibody
T27864	11016-11018	IN	denotes	to
T27865	11019-11024	NN	denotes	DMRT7
T27866	11025-11026	-LRB-	denotes	(
T27867	11026-11031	JJ	denotes	green
T27868	11031-11032	-RRB-	denotes	)
T27869	11033-11036	CC	denotes	and
T27870	11037-11041	NN	denotes	DAPI
T27871	11042-11043	-LRB-	denotes	(
T27872	11043-11047	JJ	denotes	blue
T27873	11047-11048	-RRB-	denotes	)
T27874	11048-11049	.	denotes	.
T27875	11049-11096	sentence	denotes	(D) DMRT7 subcellular localization to XY body.
T27876	11050-11051	-LRB-	denotes	(
T27877	11051-11052	LS	denotes	D
T27878	11072-11084	NN	denotes	localization
T27879	11052-11053	-RRB-	denotes	)
T27880	11054-11059	NN	denotes	DMRT7
T27881	11060-11071	JJ	denotes	subcellular
T27882	11085-11087	IN	denotes	to
T27883	11088-11090	NN	denotes	XY
T27884	11091-11095	NN	denotes	body
T27885	11095-11096	.	denotes	.
T27886	11096-11190	sentence	denotes	Testis sections from 6-wk-old male stained with antibodies to DMRT7 (red) and SUMO-1 (green).
T27887	11097-11103	NN	denotes	Testis
T27888	11104-11112	NNS	denotes	sections
T27889	11113-11117	IN	denotes	from
T27890	11118-11119	CD	denotes	6
T27891	11120-11122	NN	denotes	wk
T27892	11119-11120	HYPH	denotes	-
T27893	11123-11126	JJ	denotes	old
T27894	11122-11123	HYPH	denotes	-
T27895	11127-11131	JJ	denotes	male
T27896	11132-11139	VBN	denotes	stained
T27897	11140-11144	IN	denotes	with
T27898	11145-11155	NNS	denotes	antibodies
T27899	11156-11158	IN	denotes	to
T27900	11159-11164	NN	denotes	DMRT7
T27901	11165-11166	-LRB-	denotes	(
T27902	11166-11169	JJ	denotes	red
T27903	11169-11170	-RRB-	denotes	)
T27904	11171-11174	CC	denotes	and
T27905	11175-11179	NN	denotes	SUMO
T27906	11179-11180	HYPH	denotes	-
T27907	11180-11181	CD	denotes	1
T27908	11182-11183	-LRB-	denotes	(
T27909	11183-11188	JJ	denotes	green
T27910	11188-11189	-RRB-	denotes	)
T27911	11189-11190	.	denotes	.
T27912	11190-11226	sentence	denotes	SUMO-1 is localized to the XY body.
T27913	11191-11195	NN	denotes	SUMO
T27914	11201-11210	VBN	denotes	localized
T27916	11196-11197	CD	denotes	1
T27917	11198-11200	VBZ	denotes	is
T27918	11211-11213	IN	denotes	to
T27919	11214-11217	DT	denotes	the
T27920	11221-11225	NN	denotes	body
T27921	11218-11220	NN	denotes	XY
T27922	11225-11226	.	denotes	.
T27923	11226-11276	sentence	denotes	Right-most panel shows merge of other two panels.
T27924	11227-11237	JJ	denotes	Right-most
T27925	11238-11243	NN	denotes	panel
T27926	11244-11249	VBZ	denotes	shows
T27927	11250-11255	NN	denotes	merge
T27928	11256-11258	IN	denotes	of
T27929	11259-11264	JJ	denotes	other
T27930	11269-11275	NNS	denotes	panels
T27931	11265-11268	CD	denotes	two
T27932	11275-11276	.	denotes	.
T27933	11276-11353	sentence	denotes	Inserts show higher magnification of pachytene spermatocytes with XY bodies.
T27934	11277-11284	NNS	denotes	Inserts
T27935	11285-11289	VBP	denotes	show
T27936	11290-11296	JJR	denotes	higher
T27937	11297-11310	NN	denotes	magnification
T27938	11311-11313	IN	denotes	of
T27939	11314-11323	NN	denotes	pachytene
T27940	11324-11337	NNS	denotes	spermatocytes
T27941	11338-11342	IN	denotes	with
T27942	11343-11345	NN	denotes	XY
T27943	11346-11352	NNS	denotes	bodies
T27944	11352-11353	.	denotes	.
T28554	17541-17542	-RRB-	denotes	)
T28555	17542-17544	,	denotes	,
T28556	17544-17547	CC	denotes	and
T28557	17548-17550	CD	denotes	42
T28558	17551-17552	NN	denotes	d
T28480	17305-17312	VBN	denotes	Reduced
T28481	17320-17324	NN	denotes	Size
T28482	17313-17319	NN	denotes	Testis
T28483	17325-17328	CC	denotes	and
T28484	17329-17333	NN	denotes	Germ
T28485	17334-17338	NN	denotes	Cell
T28486	17339-17348	NN	denotes	Apoptosis
T28487	17349-17351	IN	denotes	in
T28488	17352-17356	NNS	denotes	Mice
T28489	17357-17361	IN	denotes	with
T28490	17362-17370	VBN	denotes	Targeted
T28491	17371-17379	NN	denotes	Deletion
T28492	17380-17382	IN	denotes	in
T28493	17383-17388	NN	denotes	Dmrt7
T28494	17388-17485	sentence	denotes	(A) Testes from a 6-wk-old wild-type (+/+) mouse and a homozygous (−/−) Dmrt7 mutant littermate.
T28495	17389-17390	-LRB-	denotes	(
T28496	17390-17391	LS	denotes	A
T28497	17393-17399	NNS	denotes	Testes
T28498	17391-17392	-RRB-	denotes	)
T28499	17400-17404	IN	denotes	from
T28500	17405-17406	DT	denotes	a
T28501	17432-17437	NN	denotes	mouse
T28502	17407-17408	CD	denotes	6
T28503	17409-17411	NN	denotes	wk
T28504	17408-17409	HYPH	denotes	-
T28505	17412-17415	JJ	denotes	old
T28506	17411-17412	HYPH	denotes	-
T28507	17416-17420	JJ	denotes	wild
T28508	17421-17425	NN	denotes	type
T28509	17420-17421	HYPH	denotes	-
T28510	17426-17427	-LRB-	denotes	(
T28511	17429-17430	SYM	denotes	+
T28512	17427-17428	SYM	denotes	+
T28513	17428-17429	HYPH	denotes	/
T28514	17430-17431	-RRB-	denotes	)
T28515	17438-17441	CC	denotes	and
T28516	17442-17443	DT	denotes	a
T28517	17474-17484	NN	denotes	littermate
T28518	17444-17454	JJ	denotes	homozygous
T28519	17455-17456	-LRB-	denotes	(
T28520	17458-17459	SYM	denotes	−
T28521	17456-17457	SYM	denotes	−
T28522	17457-17458	HYPH	denotes	/
T28523	17459-17460	-RRB-	denotes	)
T28524	17461-17466	NN	denotes	Dmrt7
T28525	17467-17473	NN	denotes	mutant
T28526	17484-17485	.	denotes	.
T28527	17485-17601	sentence	denotes	(B–D) Sections of testes from 14-d-old (B), 21-d-old (C), and 42-d-old mice (D) stained with hematoxylin and eosin.
T28528	17486-17487	-LRB-	denotes	(
T28529	17487-17488	LS	denotes	B
T28530	17492-17500	NNS	denotes	Sections
T28531	17488-17489	SYM	denotes	–
T28532	17489-17490	LS	denotes	D
T28533	17490-17491	-RRB-	denotes	)
T28534	17501-17503	IN	denotes	of
T28535	17504-17510	NNS	denotes	testes
T28536	17511-17515	IN	denotes	from
T28537	17516-17518	CD	denotes	14
T28538	17519-17520	NN	denotes	d
T28539	17518-17519	HYPH	denotes	-
T28540	17521-17524	JJ	denotes	old
T28541	17520-17521	HYPH	denotes	-
T28542	17557-17561	NNS	denotes	mice
T28543	17525-17526	-LRB-	denotes	(
T28544	17526-17527	NN	denotes	B
T28545	17527-17528	-RRB-	denotes	)
T28546	17528-17530	,	denotes	,
T28547	17530-17532	CD	denotes	21
T28548	17533-17534	NN	denotes	d
T28549	17532-17533	HYPH	denotes	-
T28550	17535-17538	JJ	denotes	old
T28551	17534-17535	HYPH	denotes	-
T28552	17539-17540	-LRB-	denotes	(
T28553	17540-17541	NN	denotes	C
T28559	17550-17551	HYPH	denotes	-
T28560	17553-17556	JJ	denotes	old
T28561	17552-17553	HYPH	denotes	-
T28562	17562-17563	-LRB-	denotes	(
T28563	17563-17564	NN	denotes	D
T28564	17564-17565	-RRB-	denotes	)
T28565	17566-17573	VBN	denotes	stained
T28566	17574-17578	IN	denotes	with
T28567	17579-17590	NN	denotes	hematoxylin
T28568	17591-17594	CC	denotes	and
T28569	17595-17600	NN	denotes	eosin
T28570	17600-17601	.	denotes	.
T28571	17601-17650	sentence	denotes	Wild-type is in left column and mutant in right.
T28572	17602-17606	JJ	denotes	Wild
T28573	17607-17611	NN	denotes	type
T28574	17606-17607	HYPH	denotes	-
T28575	17612-17614	VBZ	denotes	is
T28576	17615-17617	IN	denotes	in
T28577	17618-17622	JJ	denotes	left
T28578	17623-17629	NN	denotes	column
T28579	17630-17633	CC	denotes	and
T28580	17634-17640	NN	denotes	mutant
T28581	17641-17643	IN	denotes	in
T28582	17644-17649	JJ	denotes	right
T28583	17649-17650	.	denotes	.
T28584	17650-17857	sentence	denotes	No significant difference is observed at 14 d (B), but by 21 d some tubules are lacking abundant spermatocytes (C, asterisk) or cells with typical apoptotic morphology are present (open arrowhead, C and D).
T28585	17651-17653	DT	denotes	No
T28586	17666-17676	NN	denotes	difference
T28587	17654-17665	JJ	denotes	significant
T28588	17680-17688	VBN	denotes	observed
T28589	17677-17679	VBZ	denotes	is
T28590	17689-17691	IN	denotes	at
T28591	17692-17694	CD	denotes	14
T28592	17695-17696	NNS	denotes	d
T28593	17697-17698	-LRB-	denotes	(
T28594	17698-17699	NN	denotes	B
T28595	17699-17700	-RRB-	denotes	)
T28596	17700-17702	,	denotes	,
T28597	17702-17705	CC	denotes	but
T28598	17706-17708	IN	denotes	by
T28599	17731-17738	VBG	denotes	lacking
T28600	17709-17711	CD	denotes	21
T28601	17712-17713	NNS	denotes	d
T28602	17714-17718	DT	denotes	some
T28603	17719-17726	NNS	denotes	tubules
T28604	17727-17730	VBP	denotes	are
T28605	17739-17747	JJ	denotes	abundant
T28606	17748-17761	NNS	denotes	spermatocytes
T28607	17762-17763	-LRB-	denotes	(
T28608	17766-17774	NN	denotes	asterisk
T28609	17763-17764	NN	denotes	C
T28610	17764-17766	,	denotes	,
T28611	17774-17775	-RRB-	denotes	)
T28612	17776-17778	CC	denotes	or
T28613	17779-17784	NNS	denotes	cells
T28614	17819-17822	VBP	denotes	are
T28615	17785-17789	IN	denotes	with
T28616	17790-17797	JJ	denotes	typical
T28617	17808-17818	NN	denotes	morphology
T28618	17798-17807	JJ	denotes	apoptotic
T28619	17823-17830	JJ	denotes	present
T28620	17831-17832	-LRB-	denotes	(
T28621	17848-17849	NN	denotes	C
T28622	17832-17836	JJ	denotes	open
T28623	17837-17846	NN	denotes	arrowhead
T28624	17846-17848	,	denotes	,
T28625	17850-17853	CC	denotes	and
T28626	17854-17855	NN	denotes	D
T28627	17855-17856	-RRB-	denotes	)
T28628	17856-17857	.	denotes	.
T28629	17857-17923	sentence	denotes	Mutant tubules contain multinucleate cells (closed arrowhead, D).
T28630	17858-17864	NN	denotes	Mutant
T28631	17865-17872	NNS	denotes	tubules
T28632	17873-17880	VBP	denotes	contain
T28633	17881-17894	JJ	denotes	multinucleate
T28634	17895-17900	NNS	denotes	cells
T28635	17901-17902	-LRB-	denotes	(
T28636	17920-17921	NN	denotes	D
T28637	17902-17908	VBN	denotes	closed
T28638	17909-17918	NN	denotes	arrowhead
T28639	17918-17920	,	denotes	,
T28640	17921-17922	-RRB-	denotes	)
T28641	17922-17923	.	denotes	.
T28642	17923-17981	sentence	denotes	(E and F) TUNEL labeling of Dmrt7-deficient mouse testes.
T28643	17924-17925	-LRB-	denotes	(
T28644	17925-17926	LS	denotes	E
T28645	17940-17948	NN	denotes	labeling
T28646	17927-17930	CC	denotes	and
T28647	17931-17932	LS	denotes	F
T28648	17932-17933	-RRB-	denotes	)
T28649	17934-17939	NN	denotes	TUNEL
T28650	17949-17951	IN	denotes	of
T28651	17952-17957	NN	denotes	Dmrt7
T28652	17958-17967	JJ	denotes	deficient
T28653	17957-17958	HYPH	denotes	-
T28654	17974-17980	NNS	denotes	testes
T28655	17968-17973	NN	denotes	mouse
T28656	17980-17981	.	denotes	.
T28657	17981-18096	sentence	denotes	Testes from wild-type and homozygous mutant littermates were analyzed by TUNEL labeling to detect apoptotic cells.
T28658	17982-17988	NNS	denotes	Testes
T28659	18043-18051	VBN	denotes	analyzed
T28660	17989-17993	IN	denotes	from
T28661	17994-17998	JJ	denotes	wild
T28662	17999-18003	NN	denotes	type
T28663	17998-17999	HYPH	denotes	-
T28664	18026-18037	NNS	denotes	littermates
T28665	18004-18007	CC	denotes	and
T28666	18008-18018	JJ	denotes	homozygous
T28667	18019-18025	NN	denotes	mutant
T28668	18038-18042	VBD	denotes	were
T28669	18052-18054	IN	denotes	by
T28670	18055-18060	NN	denotes	TUNEL
T28671	18061-18069	NN	denotes	labeling
T28672	18070-18072	TO	denotes	to
T28673	18073-18079	VB	denotes	detect
T28674	18080-18089	JJ	denotes	apoptotic
T28675	18090-18095	NNS	denotes	cells
T28676	18095-18096	.	denotes	.
T28677	18096-18153	sentence	denotes	Testis sections from 21-d-old (E) and 6-wk-old mice (F).
T28678	18097-18103	NN	denotes	Testis
T28679	18104-18112	NNS	denotes	sections
T28680	18113-18117	IN	denotes	from
T28681	18118-18120	CD	denotes	21
T28682	18121-18122	NN	denotes	d
T28683	18120-18121	HYPH	denotes	-
T28684	18123-18126	JJ	denotes	old
T28685	18122-18123	HYPH	denotes	-
T28686	18144-18148	NNS	denotes	mice
T28687	18127-18128	-LRB-	denotes	(
T28688	18128-18129	NN	denotes	E
T28689	18129-18130	-RRB-	denotes	)
T28690	18131-18134	CC	denotes	and
T28691	18135-18136	CD	denotes	6
T28692	18137-18139	NN	denotes	wk
T28693	18136-18137	HYPH	denotes	-
T28694	18140-18143	JJ	denotes	old
T28695	18139-18140	HYPH	denotes	-
T28696	18149-18150	-LRB-	denotes	(
T28697	18150-18151	NN	denotes	F
T28698	18151-18152	-RRB-	denotes	)
T28699	18152-18153	.	denotes	.
T28700	18153-18279	sentence	denotes	Apoptotic cells (brown) are much more abundant in seminiferous tubules of homozygous Dmrt7 mutant mice relative to wild-type.
T28701	18154-18163	JJ	denotes	Apoptotic
T28702	18164-18169	NNS	denotes	cells
T28703	18178-18181	VBP	denotes	are
T28704	18170-18171	-LRB-	denotes	(
T28705	18171-18176	JJ	denotes	brown
T28706	18176-18177	-RRB-	denotes	)
T28707	18182-18186	RB	denotes	much
T28708	18187-18191	RBR	denotes	more
T28709	18192-18200	JJ	denotes	abundant
T28710	18201-18203	IN	denotes	in
T28711	18204-18216	JJ	denotes	seminiferous
T28712	18217-18224	NNS	denotes	tubules
T28713	18225-18227	IN	denotes	of
T28714	18228-18238	JJ	denotes	homozygous
T28715	18252-18256	NNS	denotes	mice
T28716	18239-18244	NN	denotes	Dmrt7
T28717	18245-18251	NN	denotes	mutant
T28718	18257-18265	JJ	denotes	relative
T28719	18266-18268	IN	denotes	to
T28720	18269-18273	JJ	denotes	wild
T28721	18274-18278	NN	denotes	type
T28722	18273-18274	HYPH	denotes	-
T28723	18278-18279	.	denotes	.
T28724	18279-18311	sentence	denotes	Bars in (B–F) represent 100 μm.
T28725	18280-18284	NNS	denotes	Bars
T28726	18294-18303	VBP	denotes	represent
T28727	18285-18287	IN	denotes	in
T28728	18288-18289	-LRB-	denotes	(
T28729	18289-18290	NN	denotes	B
T28730	18290-18291	SYM	denotes	–
T28731	18291-18292	NN	denotes	F
T28732	18292-18293	-RRB-	denotes	)
T28733	18304-18307	CD	denotes	100
T28734	18308-18310	NNS	denotes	μm
T28735	18310-18311	.	denotes	.
T28985	20879-20887	NN	denotes	Prophase
T28986	20890-20896	NN	denotes	Arrest
T28987	20888-20889	CD	denotes	I
T28988	20897-20899	IN	denotes	of
T28989	20900-20905	NN	denotes	Dmrt7
T28990	20906-20912	NN	denotes	Mutant
T28991	20918-20923	NNS	denotes	Cells
T28992	20913-20917	NN	denotes	Germ
T28993	20923-21076	sentence	denotes	Testis sections from 6-wk-old wild-type (+/+) and Dmrt7 mutant (−/−) littermates stained with stage-specific antibodies specific to spermatogenic cells.
T28994	20924-20930	NN	denotes	Testis
T28995	20931-20939	NNS	denotes	sections
T28996	20940-20944	IN	denotes	from
T28997	20945-20946	CD	denotes	6
T28998	20947-20949	NN	denotes	wk
T28999	20946-20947	HYPH	denotes	-
T29000	20950-20953	JJ	denotes	old
T29001	20949-20950	HYPH	denotes	-
T29002	20993-21004	NNS	denotes	littermates
T29003	20954-20958	JJ	denotes	wild
T29004	20959-20963	NN	denotes	type
T29005	20958-20959	HYPH	denotes	-
T29006	20964-20965	-LRB-	denotes	(
T29007	20967-20968	SYM	denotes	+
T29008	20965-20966	SYM	denotes	+
T29009	20966-20967	HYPH	denotes	/
T29010	20968-20969	-RRB-	denotes	)
T29011	20970-20973	CC	denotes	and
T29012	20974-20979	NN	denotes	Dmrt7
T29013	20980-20986	NN	denotes	mutant
T29014	20987-20988	-LRB-	denotes	(
T29015	20990-20991	SYM	denotes	−
T29016	20988-20989	SYM	denotes	−
T29017	20989-20990	HYPH	denotes	/
T29018	20991-20992	-RRB-	denotes	)
T29019	21005-21012	VBN	denotes	stained
T29020	21013-21017	IN	denotes	with
T29021	21018-21023	NN	denotes	stage
T29022	21024-21032	JJ	denotes	specific
T29023	21023-21024	HYPH	denotes	-
T29024	21033-21043	NNS	denotes	antibodies
T29025	21044-21052	JJ	denotes	specific
T29026	21053-21055	IN	denotes	to
T29027	21056-21069	JJ	denotes	spermatogenic
T29028	21070-21075	NNS	denotes	cells
T29029	21075-21076	.	denotes	.
T29030	21076-21169	sentence	denotes	(A) TRA98 antibody strongly stains spermatogonia, which are present in wild-type and mutant.
T29031	21077-21078	-LRB-	denotes	(
T29032	21078-21079	LS	denotes	A
T29033	21105-21111	VBZ	denotes	stains
T29034	21079-21080	-RRB-	denotes	)
T29035	21081-21086	NN	denotes	TRA98
T29036	21087-21095	NN	denotes	antibody
T29037	21096-21104	RB	denotes	strongly
T29038	21112-21125	NNS	denotes	spermatogonia
T29039	21125-21127	,	denotes	,
T29040	21127-21132	WDT	denotes	which
T29041	21133-21136	VBP	denotes	are
T29042	21137-21144	JJ	denotes	present
T29043	21145-21147	IN	denotes	in
T29044	21148-21152	JJ	denotes	wild
T29045	21153-21157	NN	denotes	type
T29046	21152-21153	HYPH	denotes	-
T29047	21158-21161	CC	denotes	and
T29048	21162-21168	NN	denotes	mutant
T29049	21168-21169	.	denotes	.
T29050	21169-21251	sentence	denotes	(B) BC7 antibody stains spermatocytes, which are present in wild-type and mutant.
T29051	21170-21171	-LRB-	denotes	(
T29052	21171-21172	LS	denotes	B
T29053	21187-21193	VBZ	denotes	stains
T29054	21172-21173	-RRB-	denotes	)
T29055	21174-21177	NN	denotes	BC7
T29056	21178-21186	NN	denotes	antibody
T29057	21194-21207	NNS	denotes	spermatocytes
T29058	21207-21209	,	denotes	,
T29059	21209-21214	WDT	denotes	which
T29060	21215-21218	VBP	denotes	are
T29061	21219-21226	JJ	denotes	present
T29062	21227-21229	IN	denotes	in
T29063	21230-21234	JJ	denotes	wild
T29064	21235-21239	NN	denotes	type
T29065	21234-21235	HYPH	denotes	-
T29066	21240-21243	CC	denotes	and
T29067	21244-21250	NN	denotes	mutant
T29068	21250-21251	.	denotes	.
T29069	21251-21361	sentence	denotes	(C) TRA369 antibody stains pachytene and later germ cells, which are severely deficient in the mutant testis.
T29070	21252-21253	-LRB-	denotes	(
T29071	21253-21254	LS	denotes	C
T29072	21272-21278	VBZ	denotes	stains
T29073	21254-21255	-RRB-	denotes	)
T29074	21256-21262	NN	denotes	TRA369
T29075	21263-21271	NN	denotes	antibody
T29076	21279-21288	NN	denotes	pachytene
T29077	21304-21309	NNS	denotes	cells
T29078	21289-21292	CC	denotes	and
T29079	21293-21298	JJ	denotes	later
T29080	21299-21303	NN	denotes	germ
T29081	21309-21311	,	denotes	,
T29082	21311-21316	WDT	denotes	which
T29083	21317-21320	VBP	denotes	are
T29084	21321-21329	RB	denotes	severely
T29085	21330-21339	JJ	denotes	deficient
T29086	21340-21342	IN	denotes	in
T29087	21343-21346	DT	denotes	the
T29088	21354-21360	NN	denotes	testis
T29089	21347-21353	NN	denotes	mutant
T29090	21360-21361	.	denotes	.
T29240	21372-21379	NN	denotes	Profile
T29241	21380-21382	IN	denotes	of
T29242	21383-21390	JJ	denotes	Meiotic
T29243	21391-21397	NN	denotes	Arrest
T29244	21398-21400	IN	denotes	in
T29245	21401-21406	NN	denotes	Dmrt7
T29246	21407-21413	NN	denotes	Mutant
T29247	21414-21420	NN	denotes	Testis
T29248	21420-21681	sentence	denotes	Graph of distribution of meiotic stages of germ cells from heterozygous (n = 1,970) and homozygous mutant (n = 2,084) P26 testes, spread and stained for the synaptonemal complex protein SYCP3 to permit precise staging, which was performed as described [64,65].
T29249	21421-21426	NN	denotes	Graph
T29250	21427-21429	IN	denotes	of
T29251	21430-21442	NN	denotes	distribution
T29252	21443-21445	IN	denotes	of
T29253	21446-21453	JJ	denotes	meiotic
T29254	21454-21460	NNS	denotes	stages
T29255	21461-21463	IN	denotes	of
T29256	21464-21468	NN	denotes	germ
T29257	21469-21474	NNS	denotes	cells
T29258	21475-21479	IN	denotes	from
T29259	21480-21492	JJ	denotes	heterozygous
T29260	21520-21526	NN	denotes	mutant
T29261	21493-21494	-LRB-	denotes	(
T29262	21498-21503	CD	denotes	1,970
T29263	21494-21495	NN	denotes	n
T29264	21496-21497	SYM	denotes	=
T29265	21503-21504	-RRB-	denotes	)
T29266	21505-21508	CC	denotes	and
T29267	21509-21519	JJ	denotes	homozygous
T29268	21543-21549	NNS	denotes	testes
T29269	21527-21528	-LRB-	denotes	(
T29270	21532-21537	CD	denotes	2,084
T29271	21528-21529	NN	denotes	n
T29272	21530-21531	SYM	denotes	=
T29273	21537-21538	-RRB-	denotes	)
T29274	21539-21542	NN	denotes	P26
T29275	21549-21551	,	denotes	,
T29276	21551-21557	VBN	denotes	spread
T29277	21558-21561	CC	denotes	and
T29278	21562-21569	VBN	denotes	stained
T29279	21570-21573	IN	denotes	for
T29280	21574-21577	DT	denotes	the
T29281	21607-21612	NN	denotes	SYCP3
T29282	21578-21590	JJ	denotes	synaptonemal
T29283	21591-21598	NN	denotes	complex
T29284	21599-21606	NN	denotes	protein
T29285	21613-21615	TO	denotes	to
T29286	21616-21622	VB	denotes	permit
T29287	21623-21630	JJ	denotes	precise
T29288	21631-21638	NN	denotes	staging
T29289	21638-21640	,	denotes	,
T29290	21640-21645	WDT	denotes	which
T29291	21650-21659	VBN	denotes	performed
T29292	21646-21649	VBD	denotes	was
T29293	21660-21662	IN	denotes	as
T29294	21663-21672	VBN	denotes	described
T29295	21673-21674	-LRB-	denotes	[
T29296	21677-21679	CD	denotes	65
T29297	21674-21676	CD	denotes	64
T29298	21676-21677	,	denotes	,
T29299	21679-21680	-RRB-	denotes	]
T29300	21680-21681	.	denotes	.
T29623	22993-22999	JJ	denotes	Normal
T29624	23000-23008	NN	denotes	Synapsis
T29625	23009-23012	CC	denotes	and
T29626	23013-23026	NN	denotes	Recombination
T29627	23027-23029	IN	denotes	in
T29628	23030-23035	NN	denotes	Dmrt7
T29629	23036-23042	NN	denotes	Mutant
T29630	23048-23053	NNS	denotes	Cells
T29631	23043-23047	NN	denotes	Germ
T29632	23053-23190	sentence	denotes	(A) Testicular cells from Dmrt7 heterozygous (+/−) or homozygous (−/−) mutant mice were spread and stained with antibody to SYCP3 (red).
T29633	23054-23055	-LRB-	denotes	(
T29634	23055-23056	LS	denotes	A
T29635	23142-23148	VBN	denotes	spread
T29636	23056-23057	-RRB-	denotes	)
T29637	23058-23068	JJ	denotes	Testicular
T29638	23069-23074	NNS	denotes	cells
T29639	23075-23079	IN	denotes	from
T29640	23080-23085	NN	denotes	Dmrt7
T29641	23125-23131	NN	denotes	mutant
T29642	23086-23098	JJ	denotes	heterozygous
T29643	23099-23100	-LRB-	denotes	(
T29644	23102-23103	SYM	denotes	−
T29645	23100-23101	SYM	denotes	+
T29646	23101-23102	HYPH	denotes	/
T29647	23103-23104	-RRB-	denotes	)
T29648	23105-23107	CC	denotes	or
T29649	23108-23118	JJ	denotes	homozygous
T29650	23119-23120	-LRB-	denotes	(
T29651	23122-23123	SYM	denotes	−
T29652	23120-23121	SYM	denotes	−
T29653	23121-23122	HYPH	denotes	/
T29654	23123-23124	-RRB-	denotes	)
T29655	23132-23136	NNS	denotes	mice
T29656	23137-23141	VBD	denotes	were
T29657	23149-23152	CC	denotes	and
T29658	23153-23160	VBN	denotes	stained
T29659	23161-23165	IN	denotes	with
T29660	23166-23174	NN	denotes	antibody
T29661	23175-23177	IN	denotes	to
T29662	23178-23183	NN	denotes	SYCP3
T29663	23184-23185	-LRB-	denotes	(
T29664	23185-23188	JJ	denotes	red
T29665	23188-23189	-RRB-	denotes	)
T29666	23189-23190	.	denotes	.
T29667	23190-23292	sentence	denotes	The developmental stages of meiotic prophase based on SYCP3 organization are indicated in each panel.
T29668	23191-23194	DT	denotes	The
T29669	23209-23215	NNS	denotes	stages
T29670	23195-23208	JJ	denotes	developmental
T29671	23268-23277	VBN	denotes	indicated
T29672	23216-23218	IN	denotes	of
T29673	23219-23226	JJ	denotes	meiotic
T29674	23227-23235	NN	denotes	prophase
T29675	23236-23241	VBN	denotes	based
T29676	23242-23244	IN	denotes	on
T29677	23245-23250	NN	denotes	SYCP3
T29678	23251-23263	NN	denotes	organization
T29679	23264-23267	VBP	denotes	are
T29680	23278-23280	IN	denotes	in
T29681	23281-23285	DT	denotes	each
T29682	23286-23291	NN	denotes	panel
T29683	23291-23292	.	denotes	.
T29684	23292-23443	sentence	denotes	By pachynema, all autosomes are fully synapsed, and the XY bivalent is synapsed only at the pseudoautosomal region in both wild-type and mutant cells.
T29685	23293-23295	IN	denotes	By
T29686	23331-23339	VBN	denotes	synapsed
T29687	23296-23305	NN	denotes	pachynema
T29688	23305-23307	,	denotes	,
T29689	23307-23310	DT	denotes	all
T29690	23311-23320	NNS	denotes	autosomes
T29691	23321-23324	VBP	denotes	are
T29692	23325-23330	RB	denotes	fully
T29693	23339-23341	,	denotes	,
T29694	23341-23344	CC	denotes	and
T29695	23345-23348	DT	denotes	the
T29696	23349-23351	NN	denotes	XY
T29697	23364-23372	VBN	denotes	synapsed
T29698	23352-23360	JJ	denotes	bivalent
T29699	23361-23363	VBZ	denotes	is
T29700	23373-23377	RB	denotes	only
T29701	23378-23380	IN	denotes	at
T29702	23381-23384	DT	denotes	the
T29703	23401-23407	NN	denotes	region
T29704	23385-23400	JJ	denotes	pseudoautosomal
T29705	23408-23410	IN	denotes	in
T29706	23411-23415	CC	denotes	both
T29707	23421-23425	NN	denotes	type
T29708	23416-23420	JJ	denotes	wild
T29709	23420-23421	HYPH	denotes	-
T29710	23437-23442	NNS	denotes	cells
T29711	23426-23429	CC	denotes	and
T29712	23430-23436	NN	denotes	mutant
T29713	23442-23443	.	denotes	.
T29714	23443-23559	sentence	denotes	(B) Testicular cells in zygonema and pachynema spread and stained with antibodies to RAD51 (green) and SYCP3 (red).
T29715	23444-23445	-LRB-	denotes	(
T29716	23445-23446	LS	denotes	B
T29717	23459-23464	NNS	denotes	cells
T29718	23446-23447	-RRB-	denotes	)
T29719	23448-23458	JJ	denotes	Testicular
T29720	23465-23467	IN	denotes	in
T29721	23468-23476	NN	denotes	zygonema
T29722	23477-23480	CC	denotes	and
T29723	23481-23490	NN	denotes	pachynema
T29724	23491-23497	VBN	denotes	spread
T29725	23498-23501	CC	denotes	and
T29726	23502-23509	VBN	denotes	stained
T29727	23510-23514	IN	denotes	with
T29728	23515-23525	NNS	denotes	antibodies
T29729	23526-23528	IN	denotes	to
T29730	23529-23534	NN	denotes	RAD51
T29731	23535-23536	-LRB-	denotes	(
T29732	23536-23541	JJ	denotes	green
T29733	23541-23542	-RRB-	denotes	)
T29734	23543-23546	CC	denotes	and
T29735	23547-23552	NN	denotes	SYCP3
T29736	23553-23554	-LRB-	denotes	(
T29737	23554-23557	JJ	denotes	red
T29738	23557-23558	-RRB-	denotes	)
T29739	23558-23559	.	denotes	.
T29740	23559-23651	sentence	denotes	Size and distribution of RAD51 foci are similar between wild-type and mutant spermatocytes.
T29741	23560-23564	NN	denotes	Size
T29742	23596-23599	VBP	denotes	are
T29743	23565-23568	CC	denotes	and
T29744	23569-23581	NN	denotes	distribution
T29745	23582-23584	IN	denotes	of
T29746	23585-23590	NN	denotes	RAD51
T29747	23591-23595	NNS	denotes	foci
T29748	23600-23607	JJ	denotes	similar
T29749	23608-23615	IN	denotes	between
T29750	23616-23620	JJ	denotes	wild
T29751	23621-23625	NN	denotes	type
T29752	23620-23621	HYPH	denotes	-
T29753	23637-23650	NNS	denotes	spermatocytes
T29754	23626-23629	CC	denotes	and
T29755	23630-23636	NN	denotes	mutant
T29756	23650-23651	.	denotes	.
T30296	24808-24816	JJ	denotes	Abnormal
T30297	24830-24842	NN	denotes	Organization
T30298	24817-24824	NNP	denotes	Sertoli
T30299	24825-24829	NN	denotes	Cell
T30300	24843-24845	IN	denotes	in
T30301	24846-24851	NN	denotes	Dmrt7
T30302	24852-24858	NN	denotes	Mutant
T30303	24859-24865	NNS	denotes	Testes
T30304	24865-24968	sentence	denotes	(A) Testes from P14 wild-type and Dmrt7 mutant mice were sectioned and stained with antibody to GATA4.
T30305	24866-24867	-LRB-	denotes	(
T30306	24867-24868	LS	denotes	A
T30307	24923-24932	VBN	denotes	sectioned
T30308	24868-24869	-RRB-	denotes	)
T30309	24870-24876	NNS	denotes	Testes
T30310	24877-24881	IN	denotes	from
T30311	24882-24885	NN	denotes	P14
T30312	24913-24917	NNS	denotes	mice
T30313	24886-24890	JJ	denotes	wild
T30314	24891-24895	NN	denotes	type
T30315	24890-24891	HYPH	denotes	-
T30316	24896-24899	CC	denotes	and
T30317	24900-24905	NN	denotes	Dmrt7
T30318	24906-24912	NN	denotes	mutant
T30319	24918-24922	VBD	denotes	were
T30320	24933-24936	CC	denotes	and
T30321	24937-24944	VBN	denotes	stained
T30322	24945-24949	IN	denotes	with
T30323	24950-24958	NN	denotes	antibody
T30324	24959-24961	IN	denotes	to
T30325	24962-24967	NN	denotes	GATA4
T30326	24967-24968	.	denotes	.
T30327	24968-25024	sentence	denotes	(B) P14 testis sections stained with antibody to GATA1.
T30328	24969-24970	-LRB-	denotes	(
T30329	24970-24971	LS	denotes	B
T30330	24984-24992	NNS	denotes	sections
T30331	24971-24972	-RRB-	denotes	)
T30332	24973-24976	NN	denotes	P14
T30333	24977-24983	NN	denotes	testis
T30334	24993-25000	VBN	denotes	stained
T30335	25001-25005	IN	denotes	with
T30336	25006-25014	NN	denotes	antibody
T30337	25015-25017	IN	denotes	to
T30338	25018-25023	NN	denotes	GATA1
T30339	25023-25024	.	denotes	.
T30340	25024-25105	sentence	denotes	At P14, GATA4 and GATA1 levels are similar in wild-type and mutant Sertoli cell.
T30341	25025-25027	IN	denotes	At
T30342	25056-25059	VBP	denotes	are
T30343	25028-25031	NN	denotes	P14
T30344	25031-25033	,	denotes	,
T30345	25033-25038	NN	denotes	GATA4
T30346	25049-25055	NNS	denotes	levels
T30347	25039-25042	CC	denotes	and
T30348	25043-25048	NN	denotes	GATA1
T30349	25060-25067	JJ	denotes	similar
T30350	25068-25070	IN	denotes	in
T30351	25071-25075	JJ	denotes	wild
T30352	25076-25080	NN	denotes	type
T30353	25075-25076	HYPH	denotes	-
T30354	25100-25104	NN	denotes	cell
T30355	25081-25084	CC	denotes	and
T30356	25085-25091	NN	denotes	mutant
T30357	25092-25099	NNP	denotes	Sertoli
T30358	25104-25105	.	denotes	.
T30359	25105-25207	sentence	denotes	(C) Wild-type and mutant testis sections double-stained with antibody to GATA1 (red) and DAPI (blue).
T30360	25106-25107	-LRB-	denotes	(
T30361	25107-25108	LS	denotes	C
T30362	25138-25146	NNS	denotes	sections
T30363	25108-25109	-RRB-	denotes	)
T30364	25110-25114	JJ	denotes	Wild
T30365	25115-25119	NN	denotes	type
T30366	25114-25115	HYPH	denotes	-
T30367	25120-25123	CC	denotes	and
T30368	25124-25130	NN	denotes	mutant
T30369	25131-25137	NN	denotes	testis
T30370	25147-25153	RB	denotes	double
T30371	25154-25161	VBN	denotes	stained
T30372	25153-25154	HYPH	denotes	-
T30373	25162-25166	IN	denotes	with
T30374	25167-25175	NN	denotes	antibody
T30375	25176-25178	IN	denotes	to
T30376	25179-25184	NN	denotes	GATA1
T30377	25185-25186	-LRB-	denotes	(
T30378	25186-25189	JJ	denotes	red
T30379	25189-25190	-RRB-	denotes	)
T30380	25191-25194	CC	denotes	and
T30381	25195-25199	NN	denotes	DAPI
T30382	25200-25201	-LRB-	denotes	(
T30383	25201-25205	JJ	denotes	blue
T30384	25205-25206	-RRB-	denotes	)
T30385	25206-25207	.	denotes	.
T30386	25207-25351	sentence	denotes	Most Sertoli cell nuclei were adjacent to the basal membrane in wild-type, but mutant Sertoli cells were displaced in some tubules (arrowhead).
T30387	25208-25212	JJS	denotes	Most
T30388	25226-25232	NNS	denotes	nuclei
T30389	25213-25220	NNP	denotes	Sertoli
T30390	25221-25225	NN	denotes	cell
T30391	25233-25237	VBD	denotes	were
T30392	25238-25246	JJ	denotes	adjacent
T30393	25247-25249	IN	denotes	to
T30394	25250-25253	DT	denotes	the
T30395	25260-25268	NN	denotes	membrane
T30396	25254-25259	JJ	denotes	basal
T30397	25269-25271	IN	denotes	in
T30398	25272-25276	JJ	denotes	wild
T30399	25277-25281	NN	denotes	type
T30400	25276-25277	HYPH	denotes	-
T30401	25281-25283	,	denotes	,
T30402	25283-25286	CC	denotes	but
T30403	25287-25293	NN	denotes	mutant
T30404	25302-25307	NNS	denotes	cells
T30405	25294-25301	NNP	denotes	Sertoli
T30406	25313-25322	VBN	denotes	displaced
T30407	25308-25312	VBD	denotes	were
T30408	25323-25325	IN	denotes	in
T30409	25326-25330	DT	denotes	some
T30410	25331-25338	NNS	denotes	tubules
T30411	25339-25340	-LRB-	denotes	(
T30412	25340-25349	NN	denotes	arrowhead
T30413	25349-25350	-RRB-	denotes	)
T30414	25350-25351	.	denotes	.
T30415	25351-25408	sentence	denotes	White dotted line indicates position of basal membranes.
T30416	25352-25357	JJ	denotes	White
T30417	25365-25369	NN	denotes	line
T30418	25358-25364	VBN	denotes	dotted
T30419	25370-25379	VBZ	denotes	indicates
T30420	25380-25388	NN	denotes	position
T30421	25389-25391	IN	denotes	of
T30422	25392-25397	JJ	denotes	basal
T30423	25398-25407	NNS	denotes	membranes
T30424	25407-25408	.	denotes	.
T30425	25408-25546	sentence	denotes	(D) Testis sections from 10-wk-old wild-type and Sertoli cell-specific Dmrt7 mutant (SC-Dmrt7KO) mice stained with hematoxylin and eosin.
T30426	25409-25410	-LRB-	denotes	(
T30427	25410-25411	LS	denotes	D
T30428	25420-25428	NNS	denotes	sections
T30429	25411-25412	-RRB-	denotes	)
T30430	25413-25419	NN	denotes	Testis
T30431	25429-25433	IN	denotes	from
T30432	25434-25436	CD	denotes	10
T30433	25437-25439	NN	denotes	wk
T30434	25436-25437	HYPH	denotes	-
T30435	25440-25443	JJ	denotes	old
T30436	25439-25440	HYPH	denotes	-
T30437	25506-25510	NNS	denotes	mice
T30438	25444-25448	JJ	denotes	wild
T30439	25449-25453	NN	denotes	type
T30440	25448-25449	HYPH	denotes	-
T30441	25454-25457	CC	denotes	and
T30442	25458-25465	NNP	denotes	Sertoli
T30443	25466-25470	NN	denotes	cell
T30444	25471-25479	JJ	denotes	specific
T30445	25470-25471	HYPH	denotes	-
T30446	25486-25492	NN	denotes	mutant
T30447	25480-25485	NN	denotes	Dmrt7
T30448	25493-25494	-LRB-	denotes	(
T30449	25494-25496	NN	denotes	SC
T30450	25497-25504	NN	denotes	Dmrt7KO
T30451	25496-25497	HYPH	denotes	-
T30452	25504-25505	-RRB-	denotes	)
T30453	25511-25518	VBN	denotes	stained
T30454	25519-25523	IN	denotes	with
T30455	25524-25535	NN	denotes	hematoxylin
T30456	25536-25539	CC	denotes	and
T30457	25540-25545	NN	denotes	eosin
T30458	25545-25546	.	denotes	.
T30459	25546-25614	sentence	denotes	Spermatogenesis and spermiogenesis are normal in SC-Dmrt7KO testis.
T30460	25547-25562	NN	denotes	Spermatogenesis
T30461	25582-25585	VBP	denotes	are
T30462	25563-25566	CC	denotes	and
T30463	25567-25581	NN	denotes	spermiogenesis
T30464	25586-25592	JJ	denotes	normal
T30465	25593-25595	IN	denotes	in
T30466	25596-25598	NN	denotes	SC
T30467	25599-25606	NN	denotes	Dmrt7KO
T30468	25598-25599	HYPH	denotes	-
T30469	25607-25613	NN	denotes	testis
T30470	25613-25614	.	denotes	.
T30471	25614-25784	sentence	denotes	(E) Testis sections from 10-wk-old wild-type and SC-Dmrt7KO mice stained with antibodies to GATA1 (red) and smooth muscle actin (to outline seminiferous tubules; green).
T30472	25615-25616	-LRB-	denotes	(
T30473	25616-25617	LS	denotes	E
T30474	25626-25634	NNS	denotes	sections
T30475	25617-25618	-RRB-	denotes	)
T30476	25619-25625	NN	denotes	Testis
T30477	25635-25639	IN	denotes	from
T30478	25640-25642	CD	denotes	10
T30479	25643-25645	NN	denotes	wk
T30480	25642-25643	HYPH	denotes	-
T30481	25646-25649	JJ	denotes	old
T30482	25645-25646	HYPH	denotes	-
T30483	25675-25679	NNS	denotes	mice
T30484	25650-25654	JJ	denotes	wild
T30485	25655-25659	NN	denotes	type
T30486	25654-25655	HYPH	denotes	-
T30487	25660-25663	CC	denotes	and
T30488	25664-25666	NN	denotes	SC
T30489	25667-25674	NN	denotes	Dmrt7KO
T30490	25666-25667	HYPH	denotes	-
T30491	25680-25687	VBN	denotes	stained
T30492	25688-25692	IN	denotes	with
T30493	25693-25703	NNS	denotes	antibodies
T30494	25704-25706	IN	denotes	to
T30495	25707-25712	NN	denotes	GATA1
T30496	25713-25714	-LRB-	denotes	(
T30497	25714-25717	JJ	denotes	red
T30498	25717-25718	-RRB-	denotes	)
T30499	25719-25722	CC	denotes	and
T30500	25723-25729	JJ	denotes	smooth
T30501	25737-25742	NN	denotes	actin
T30502	25730-25736	NN	denotes	muscle
T30503	25743-25744	-LRB-	denotes	(
T30504	25747-25754	VB	denotes	outline
T30505	25744-25746	TO	denotes	to
T30506	25755-25767	JJ	denotes	seminiferous
T30507	25768-25775	NNS	denotes	tubules
T30508	25775-25776	:	denotes	;
T30509	25777-25782	JJ	denotes	green
T30510	25782-25783	-RRB-	denotes	)
T30511	25783-25784	.	denotes	.
T30512	25784-25872	sentence	denotes	Sertoli cell nuclei are positioned normally near the basal membrane in SC-Dmrt7KO mice.
T30513	25785-25792	NNP	denotes	Sertoli
T30514	25793-25797	NN	denotes	cell
T30515	25798-25804	NNS	denotes	nuclei
T30516	25809-25819	VBN	denotes	positioned
T30517	25805-25808	VBP	denotes	are
T30518	25820-25828	RB	denotes	normally
T30519	25829-25833	IN	denotes	near
T30520	25834-25837	DT	denotes	the
T30521	25844-25852	NN	denotes	membrane
T30522	25838-25843	JJ	denotes	basal
T30523	25853-25855	IN	denotes	in
T30524	25856-25858	NN	denotes	SC
T30525	25859-25866	NN	denotes	Dmrt7KO
T30526	25858-25859	HYPH	denotes	-
T30527	25867-25871	NNS	denotes	mice
T30528	25871-25872	.	denotes	.
T30819	29693-29699	VBN	denotes	spread
T30820	29700-29703	CC	denotes	and
T30803	29611-29613	NN	denotes	XY
T30804	29614-29618	NN	denotes	Body
T30805	29619-29624	VBZ	denotes	Forms
T30806	29625-29633	RB	denotes	Normally
T30807	29634-29640	IN	denotes	during
T30808	29641-29650	NN	denotes	Pachynema
T30809	29651-29653	IN	denotes	in
T30810	29654-29659	NN	denotes	Dmrt7
T30811	29660-29666	NN	denotes	Mutant
T30812	29667-29671	NNS	denotes	Mice
T30813	29671-29761	sentence	denotes	(A) Testicular cells spread and stained with antibodies to γH2AX (red) and SYCP3 (green).
T30814	29672-29673	-LRB-	denotes	(
T30815	29687-29692	NNS	denotes	cells
T30816	29673-29674	LS	denotes	A
T30817	29674-29675	-RRB-	denotes	)
T30818	29676-29686	JJ	denotes	Testicular
T30821	29704-29711	VBN	denotes	stained
T30822	29712-29716	IN	denotes	with
T30823	29717-29727	NNS	denotes	antibodies
T30824	29728-29730	IN	denotes	to
T30825	29731-29736	NN	denotes	γH2AX
T30826	29737-29738	-LRB-	denotes	(
T30827	29738-29741	JJ	denotes	red
T30828	29741-29742	-RRB-	denotes	)
T30829	29743-29746	CC	denotes	and
T30830	29747-29752	NN	denotes	SYCP3
T30831	29753-29754	-LRB-	denotes	(
T30832	29754-29759	JJ	denotes	green
T30833	29759-29760	-RRB-	denotes	)
T30834	29760-29761	.	denotes	.
T30835	29761-29854	sentence	denotes	In pachytene cells, γH2AX is concentrated in the XY body both in wild-type and Dmrt7 mutant.
T30836	29762-29764	IN	denotes	In
T30837	29791-29803	VBN	denotes	concentrated
T30838	29765-29774	NN	denotes	pachytene
T30839	29775-29780	NNS	denotes	cells
T30840	29780-29782	,	denotes	,
T30841	29782-29787	NN	denotes	γH2AX
T30842	29788-29790	VBZ	denotes	is
T30843	29804-29806	IN	denotes	in
T30844	29807-29810	DT	denotes	the
T30845	29814-29818	NN	denotes	body
T30846	29811-29813	NN	denotes	XY
T30847	29819-29823	CC	denotes	both
T30848	29824-29826	IN	denotes	in
T30849	29827-29831	JJ	denotes	wild
T30850	29832-29836	NN	denotes	type
T30851	29831-29832	HYPH	denotes	-
T30852	29837-29840	CC	denotes	and
T30853	29841-29846	NN	denotes	Dmrt7
T30854	29847-29853	NN	denotes	mutant
T30855	29853-29854	.	denotes	.
T30856	29854-29936	sentence	denotes	(B) Testes from 6-wk-old mice sectioned and stained with antibody to γH2AX (red).
T30857	29855-29856	-LRB-	denotes	(
T30858	29856-29857	LS	denotes	B
T30859	29859-29865	NNS	denotes	Testes
T30860	29857-29858	-RRB-	denotes	)
T30861	29866-29870	IN	denotes	from
T30862	29871-29872	CD	denotes	6
T30863	29873-29875	NN	denotes	wk
T30864	29872-29873	HYPH	denotes	-
T30865	29876-29879	JJ	denotes	old
T30866	29875-29876	HYPH	denotes	-
T30867	29880-29884	NNS	denotes	mice
T30868	29885-29894	VBN	denotes	sectioned
T30869	29895-29898	CC	denotes	and
T30870	29899-29906	VBN	denotes	stained
T30871	29907-29911	IN	denotes	with
T30872	29912-29920	NN	denotes	antibody
T30873	29921-29923	IN	denotes	to
T30874	29924-29929	NN	denotes	γH2AX
T30875	29930-29931	-LRB-	denotes	(
T30876	29931-29934	JJ	denotes	red
T30877	29934-29935	-RRB-	denotes	)
T30878	29935-29936	.	denotes	.
T30879	29936-30021	sentence	denotes	(C) Testes from 6-wk-old mice sectioned and stained with antibody to SUMO-1 (green).
T30880	29937-29938	-LRB-	denotes	(
T30881	29938-29939	LS	denotes	C
T30882	29941-29947	NNS	denotes	Testes
T30883	29939-29940	-RRB-	denotes	)
T30884	29948-29952	IN	denotes	from
T30885	29953-29954	CD	denotes	6
T30886	29955-29957	NN	denotes	wk
T30887	29954-29955	HYPH	denotes	-
T30888	29958-29961	JJ	denotes	old
T30889	29957-29958	HYPH	denotes	-
T30890	29962-29966	NNS	denotes	mice
T30891	29967-29976	VBN	denotes	sectioned
T30892	29977-29980	CC	denotes	and
T30893	29981-29988	VBN	denotes	stained
T30894	29989-29993	IN	denotes	with
T30895	29994-30002	NN	denotes	antibody
T30896	30003-30005	IN	denotes	to
T30897	30006-30010	NN	denotes	SUMO
T30898	30010-30011	HYPH	denotes	-
T30899	30011-30012	CD	denotes	1
T30900	30013-30014	-LRB-	denotes	(
T30901	30014-30019	JJ	denotes	green
T30902	30019-30020	-RRB-	denotes	)
T30903	30020-30021	.	denotes	.
T30904	30021-30105	sentence	denotes	Abundant pachytene cells with XY bodies are present in wild-type and mutant testes.
T30905	30022-30030	JJ	denotes	Abundant
T30906	30041-30046	NNS	denotes	cells
T30907	30031-30040	NN	denotes	pachytene
T30908	30062-30065	VBP	denotes	are
T30909	30047-30051	IN	denotes	with
T30910	30052-30054	NN	denotes	XY
T30911	30055-30061	NNS	denotes	bodies
T30912	30066-30073	JJ	denotes	present
T30913	30074-30076	IN	denotes	in
T30914	30077-30081	JJ	denotes	wild
T30915	30082-30086	NN	denotes	type
T30916	30081-30082	HYPH	denotes	-
T30917	30098-30104	NNS	denotes	testes
T30918	30087-30090	CC	denotes	and
T30919	30091-30097	NN	denotes	mutant
T30920	30104-30105	.	denotes	.
T31607	32061-32070	NN	denotes	Chromatin
T31608	32071-32084	NNS	denotes	Abnormalities
T31609	32085-32087	IN	denotes	in
T31610	32088-32093	NN	denotes	Dmrt7
T31611	32094-32100	NN	denotes	Mutant
T31612	32116-32121	NNS	denotes	Cells
T31613	32101-32110	NN	denotes	Diplotene
T31614	32111-32115	NN	denotes	Germ
T31615	32121-32199	sentence	denotes	(A and B) MSCI occurs normally in mid-pachytene spermatocyte of Dmrt7 mutant.
T31616	32122-32123	-LRB-	denotes	(
T31617	32123-32124	LS	denotes	A
T31618	32137-32143	VBZ	denotes	occurs
T31619	32125-32128	CC	denotes	and
T31620	32129-32130	LS	denotes	B
T31621	32130-32131	-RRB-	denotes	)
T31622	32132-32136	NN	denotes	MSCI
T31623	32144-32152	RB	denotes	normally
T31624	32153-32155	IN	denotes	in
T31625	32156-32169	JJ	denotes	mid-pachytene
T31626	32170-32182	NN	denotes	spermatocyte
T31627	32183-32185	IN	denotes	of
T31628	32186-32191	NN	denotes	Dmrt7
T31629	32192-32198	NN	denotes	mutant
T31630	32198-32199	.	denotes	.
T31631	32199-32238	sentence	denotes	Arrows indicate XY body in all panels.
T31632	32200-32206	NNS	denotes	Arrows
T31633	32207-32215	VBP	denotes	indicate
T31634	32216-32218	NN	denotes	XY
T31635	32219-32223	NN	denotes	body
T31636	32224-32226	IN	denotes	in
T31637	32227-32230	DT	denotes	all
T31638	32231-32237	NNS	denotes	panels
T31639	32237-32238	.	denotes	.
T31640	32238-32328	sentence	denotes	Cot-1 RNA FISH (red) reveals normal silencing of sex chromosome transcription in XY body.
T31641	32239-32242	NN	denotes	Cot
T31642	32249-32253	NN	denotes	FISH
T31643	32242-32243	HYPH	denotes	-
T31644	32243-32244	CD	denotes	1
T31645	32245-32248	NN	denotes	RNA
T31646	32260-32267	VBZ	denotes	reveals
T31647	32254-32255	-LRB-	denotes	(
T31648	32255-32258	JJ	denotes	red
T31649	32258-32259	-RRB-	denotes	)
T31650	32268-32274	JJ	denotes	normal
T31651	32275-32284	NN	denotes	silencing
T31652	32285-32287	IN	denotes	of
T31653	32288-32291	NN	denotes	sex
T31654	32303-32316	NN	denotes	transcription
T31655	32292-32302	NN	denotes	chromosome
T31656	32317-32319	IN	denotes	in
T31657	32320-32322	NN	denotes	XY
T31658	32323-32327	NN	denotes	body
T31659	32327-32328	.	denotes	.
T31660	32328-32406	sentence	denotes	This is consistent with wild-type mid-pachynema as described previously [16].
T31661	32329-32333	DT	denotes	This
T31662	32334-32336	VBZ	denotes	is
T31663	32337-32347	JJ	denotes	consistent
T31664	32348-32352	IN	denotes	with
T31665	32353-32357	JJ	denotes	wild
T31666	32358-32362	NN	denotes	type
T31667	32357-32358	HYPH	denotes	-
T31668	32363-32376	NN	denotes	mid-pachynema
T31669	32377-32379	IN	denotes	as
T31670	32380-32389	VBN	denotes	described
T31671	32390-32400	RB	denotes	previously
T31672	32401-32402	-LRB-	denotes	[
T31673	32402-32404	CD	denotes	16
T31674	32404-32405	-RRB-	denotes	]
T31675	32405-32406	.	denotes	.
T31676	32406-32466	sentence	denotes	(C and D) HP1β localization in mid-pachytene spermatocytes.
T31677	32407-32408	-LRB-	denotes	(
T31678	32408-32409	LS	denotes	C
T31679	32422-32434	NN	denotes	localization
T31680	32410-32413	CC	denotes	and
T31681	32414-32415	LS	denotes	D
T31682	32415-32416	-RRB-	denotes	)
T31683	32417-32421	NN	denotes	HP1β
T31684	32435-32437	IN	denotes	in
T31685	32438-32451	JJ	denotes	mid-pachytene
T31686	32452-32465	NNS	denotes	spermatocytes
T31687	32465-32466	.	denotes	.
T31688	32466-32553	sentence	denotes	HP1β localizes to X chromosome centromere (arrowhead) in wild-type (C) and mutant (D).
T31689	32467-32471	NN	denotes	HP1β
T31690	32472-32481	VBZ	denotes	localizes
T31691	32482-32484	IN	denotes	to
T31692	32485-32486	NN	denotes	X
T31693	32487-32497	NN	denotes	chromosome
T31694	32498-32508	NN	denotes	centromere
T31695	32509-32510	-LRB-	denotes	(
T31696	32510-32519	NN	denotes	arrowhead
T31697	32519-32520	-RRB-	denotes	)
T31698	32521-32523	IN	denotes	in
T31699	32524-32528	JJ	denotes	wild
T31700	32529-32533	NN	denotes	type
T31701	32528-32529	HYPH	denotes	-
T31702	32534-32535	-LRB-	denotes	(
T31703	32535-32536	NN	denotes	C
T31704	32536-32537	-RRB-	denotes	)
T31705	32538-32541	CC	denotes	and
T31706	32542-32548	NN	denotes	mutant
T31707	32549-32550	-LRB-	denotes	(
T31708	32550-32551	NN	denotes	D
T31709	32551-32552	-RRB-	denotes	)
T31710	32552-32553	.	denotes	.
T31711	32553-32597	sentence	denotes	(E and F) Cot-1 hybridization in diplotene.
T31712	32554-32555	-LRB-	denotes	(
T31713	32555-32556	LS	denotes	E
T31714	32570-32583	NN	denotes	hybridization
T31715	32557-32560	CC	denotes	and
T31716	32561-32562	LS	denotes	F
T31717	32562-32563	-RRB-	denotes	)
T31718	32564-32567	NN	denotes	Cot
T31719	32567-32568	HYPH	denotes	-
T31720	32568-32569	CD	denotes	1
T31721	32584-32586	IN	denotes	in
T31722	32587-32596	NN	denotes	diplotene
T31723	32596-32597	.	denotes	.
T31724	32597-32686	sentence	denotes	Presumptive XY body, based on DAPI and γH2AX localization, is indicated by arrow in (F).
T31725	32598-32609	JJ	denotes	Presumptive
T31726	32613-32617	NN	denotes	body
T31727	32610-32612	NN	denotes	XY
T31728	32660-32669	VBN	denotes	indicated
T31729	32617-32619	,	denotes	,
T31730	32619-32624	VBN	denotes	based
T31731	32625-32627	IN	denotes	on
T31732	32628-32632	NN	denotes	DAPI
T31733	32643-32655	NN	denotes	localization
T31734	32633-32636	CC	denotes	and
T31735	32637-32642	NN	denotes	γH2AX
T31736	32655-32657	,	denotes	,
T31737	32657-32659	VBZ	denotes	is
T31738	32670-32672	IN	denotes	by
T31739	32673-32678	NN	denotes	arrow
T31740	32679-32681	IN	denotes	in
T31741	32682-32683	-LRB-	denotes	(
T31742	32683-32684	NN	denotes	F
T31743	32684-32685	-RRB-	denotes	)
T31744	32685-32686	.	denotes	.
T31745	32686-32715	sentence	denotes	(G and H) HP1β in diplotene.
T31746	32687-32688	-LRB-	denotes	(
T31747	32688-32689	LS	denotes	G
T31748	32697-32701	NN	denotes	HP1β
T31749	32690-32693	CC	denotes	and
T31750	32694-32695	LS	denotes	H
T31751	32695-32696	-RRB-	denotes	)
T31752	32702-32704	IN	denotes	in
T31753	32705-32714	NN	denotes	diplotene
T31754	32714-32715	.	denotes	.
T31755	32715-32849	sentence	denotes	Wild-type cell (E) has HP1β throughout XY body, whereas mutant cell (H) only has localization to X chromosome centromere (arrowhead).
T31756	32716-32720	JJ	denotes	Wild
T31757	32721-32725	NN	denotes	type
T31758	32720-32721	HYPH	denotes	-
T31759	32726-32730	NN	denotes	cell
T31760	32735-32738	VBZ	denotes	has
T31761	32731-32732	-LRB-	denotes	(
T31762	32732-32733	NN	denotes	E
T31763	32733-32734	-RRB-	denotes	)
T31764	32739-32743	NN	denotes	HP1β
T31765	32744-32754	IN	denotes	throughout
T31766	32755-32757	NN	denotes	XY
T31767	32758-32762	NN	denotes	body
T31768	32762-32764	,	denotes	,
T31769	32764-32771	IN	denotes	whereas
T31770	32793-32796	VBZ	denotes	has
T31771	32772-32778	NN	denotes	mutant
T31772	32779-32783	NN	denotes	cell
T31773	32784-32785	-LRB-	denotes	(
T31774	32785-32786	NN	denotes	H
T31775	32786-32787	-RRB-	denotes	)
T31776	32788-32792	RB	denotes	only
T31777	32797-32809	NN	denotes	localization
T31778	32810-32812	IN	denotes	to
T31779	32813-32814	NN	denotes	X
T31780	32815-32825	NN	denotes	chromosome
T31781	32826-32836	NN	denotes	centromere
T31782	32837-32838	-LRB-	denotes	(
T31783	32838-32847	NN	denotes	arrowhead
T31784	32847-32848	-RRB-	denotes	)
T31785	32848-32849	.	denotes	.
T31786	32849-32901	sentence	denotes	(I and J) H3-2meK9 localization in diplotene cells.
T31787	32850-32851	-LRB-	denotes	(
T31788	32851-32852	LS	denotes	I
T31789	32869-32881	NN	denotes	localization
T31790	32853-32856	CC	denotes	and
T31791	32857-32858	LS	denotes	J
T31792	32858-32859	-RRB-	denotes	)
T31793	32860-32862	NN	denotes	H3
T31794	32863-32868	NN	denotes	2meK9
T31795	32862-32863	HYPH	denotes	-
T31796	32882-32884	IN	denotes	in
T31797	32885-32894	NN	denotes	diplotene
T31798	32895-32900	NNS	denotes	cells
T31799	32900-32901	.	denotes	.
T31800	32901-32995	sentence	denotes	Mutant cell (J) lacks strong concentration of this mark to the XY body seen in wild-type (I).
T31801	32902-32908	NN	denotes	Mutant
T31802	32909-32913	NN	denotes	cell
T31803	32918-32923	VBZ	denotes	lacks
T31804	32914-32915	-LRB-	denotes	(
T31805	32915-32916	NN	denotes	J
T31806	32916-32917	-RRB-	denotes	)
T31807	32924-32930	JJ	denotes	strong
T31808	32931-32944	NN	denotes	concentration
T31809	32945-32947	IN	denotes	of
T31810	32948-32952	DT	denotes	this
T31811	32953-32957	NN	denotes	mark
T31812	32958-32960	IN	denotes	to
T31813	32961-32964	DT	denotes	the
T31814	32968-32972	NN	denotes	body
T31815	32965-32967	NN	denotes	XY
T31816	32973-32977	VBN	denotes	seen
T31817	32978-32980	IN	denotes	in
T31818	32981-32985	JJ	denotes	wild
T31819	32986-32990	NN	denotes	type
T31820	32985-32986	HYPH	denotes	-
T31821	32991-32992	-LRB-	denotes	(
T31822	32992-32993	NN	denotes	I
T31823	32993-32994	-RRB-	denotes	)
T31824	32994-32995	.	denotes	.
T31825	32995-33047	sentence	denotes	(K and L) H3-3meK9 localization in diplotene cells.
T31826	32996-32997	-LRB-	denotes	(
T31827	32997-32998	LS	denotes	K
T31828	33015-33027	NN	denotes	localization
T31829	32999-33002	CC	denotes	and
T31830	33003-33004	LS	denotes	L
T31831	33004-33005	-RRB-	denotes	)
T31832	33006-33008	NN	denotes	H3
T31833	33009-33014	NN	denotes	3meK9
T31834	33008-33009	HYPH	denotes	-
T31835	33028-33030	IN	denotes	in
T31836	33031-33040	NN	denotes	diplotene
T31837	33041-33046	NNS	denotes	cells
T31838	33046-33047	.	denotes	.
T31839	33047-33112	sentence	denotes	Mutant cell (L) has no localization of this mark to the XY body.
T31840	33048-33054	NN	denotes	Mutant
T31841	33055-33059	NN	denotes	cell
T31842	33064-33067	VBZ	denotes	has
T31843	33060-33061	-LRB-	denotes	(
T31844	33061-33062	NN	denotes	L
T31845	33062-33063	-RRB-	denotes	)
T31846	33068-33070	DT	denotes	no
T31847	33071-33083	NN	denotes	localization
T31848	33084-33086	IN	denotes	of
T31849	33087-33091	DT	denotes	this
T31850	33092-33096	NN	denotes	mark
T31851	33097-33099	IN	denotes	to
T31852	33100-33103	DT	denotes	the
T31853	33107-33111	NN	denotes	body
T31854	33104-33106	NN	denotes	XY
T31855	33111-33112	.	denotes	.
T31856	33112-33197	sentence	denotes	γH2AX localizes to autosomes in mutant cell, possibly indicating onset of apoptosis.
T31857	33113-33118	NN	denotes	γH2AX
T31858	33119-33128	VBZ	denotes	localizes
T31859	33129-33131	IN	denotes	to
T31860	33132-33141	NNS	denotes	autosomes
T31861	33142-33144	IN	denotes	in
T31862	33145-33151	NN	denotes	mutant
T31863	33152-33156	NN	denotes	cell
T31864	33156-33158	,	denotes	,
T31865	33158-33166	RB	denotes	possibly
T31866	33167-33177	VBG	denotes	indicating
T31867	33178-33183	NN	denotes	onset
T31868	33184-33186	IN	denotes	of
T31869	33187-33196	NN	denotes	apoptosis
T31870	33196-33197	.	denotes	.
T31871	33197-33280	sentence	denotes	(M) Example of mutant diplotene cell with normal HP1β accumulation to the XY body.
T31872	33198-33199	-LRB-	denotes	(
T31873	33199-33200	LS	denotes	M
T31874	33202-33209	NN	denotes	Example
T31875	33200-33201	-RRB-	denotes	)
T31876	33210-33212	IN	denotes	of
T31877	33213-33219	NN	denotes	mutant
T31878	33230-33234	NN	denotes	cell
T31879	33220-33229	NN	denotes	diplotene
T31880	33235-33239	IN	denotes	with
T31881	33240-33246	JJ	denotes	normal
T31882	33252-33264	NN	denotes	accumulation
T31883	33247-33251	NN	denotes	HP1β
T31884	33265-33267	IN	denotes	to
T31885	33268-33271	DT	denotes	the
T31886	33275-33279	NN	denotes	body
T31887	33272-33274	NN	denotes	XY
T31888	33279-33280	.	denotes	.
T31889	33280-33334	sentence	denotes	All images except those in (M) are single Z sections.
T31890	33281-33284	DT	denotes	All
T31891	33285-33291	NNS	denotes	images
T31892	33312-33315	VBP	denotes	are
T31893	33292-33298	IN	denotes	except
T31894	33299-33304	DT	denotes	those
T31895	33305-33307	IN	denotes	in
T31896	33308-33309	-LRB-	denotes	(
T31897	33309-33310	NN	denotes	M
T31898	33310-33311	-RRB-	denotes	)
T31899	33316-33322	JJ	denotes	single
T31900	33323-33324	NN	denotes	Z
T31901	33325-33333	NNS	denotes	sections
T31902	33333-33334	.	denotes	.
T32136	36253-36265	VBN	denotes	internalized
T32137	36269-36273	NN	denotes	body
T32100	36051-36059	JJ	denotes	Abnormal
T32101	36064-36073	NN	denotes	Chromatin
T32102	36060-36063	NN	denotes	Sex
T32103	36074-36076	IN	denotes	in
T32104	36077-36082	NNS	denotes	Cells
T32105	36083-36089	VBN	denotes	Staged
T32106	36090-36092	IN	denotes	by
T32107	36093-36103	NN	denotes	Chromosome
T32108	36112-36118	NN	denotes	Status
T32109	36104-36111	VBG	denotes	Pairing
T32110	36118-36297	sentence	denotes	(A) Spread of wild-type germ cell stained with DAPI, anti-SYCP3, and anti-HP1β showing chromosome morphology typical of diplonema and internalized XY body with HP1β accumulation.
T32111	36119-36120	-LRB-	denotes	(
T32112	36120-36121	LS	denotes	A
T32113	36123-36129	NN	denotes	Spread
T32114	36121-36122	-RRB-	denotes	)
T32115	36130-36132	IN	denotes	of
T32116	36133-36137	JJ	denotes	wild
T32117	36138-36142	NN	denotes	type
T32118	36137-36138	HYPH	denotes	-
T32119	36148-36152	NN	denotes	cell
T32120	36143-36147	NN	denotes	germ
T32121	36153-36160	VBN	denotes	stained
T32122	36161-36165	IN	denotes	with
T32123	36166-36170	NN	denotes	DAPI
T32124	36170-36172	,	denotes	,
T32125	36172-36182	JJ	denotes	anti-SYCP3
T32126	36182-36184	,	denotes	,
T32127	36184-36187	CC	denotes	and
T32128	36188-36197	JJ	denotes	anti-HP1β
T32129	36198-36205	VBG	denotes	showing
T32130	36206-36216	NN	denotes	chromosome
T32131	36217-36227	NN	denotes	morphology
T32132	36228-36235	JJ	denotes	typical
T32133	36236-36238	IN	denotes	of
T32134	36239-36248	NN	denotes	diplonema
T32135	36249-36252	CC	denotes	and
T32138	36266-36268	NN	denotes	XY
T32139	36274-36278	IN	denotes	with
T32140	36279-36283	NN	denotes	HP1β
T32141	36284-36296	NN	denotes	accumulation
T32142	36296-36297	.	denotes	.
T32143	36297-36448	sentence	denotes	(B) Spread of Dmrt7 mutant germ cell showing normal diplotene chromosome morphology and internalized XY body, but no HP1β accumulation in the XY body.
T32144	36298-36299	-LRB-	denotes	(
T32145	36299-36300	LS	denotes	B
T32146	36302-36308	NN	denotes	Spread
T32147	36300-36301	-RRB-	denotes	)
T32148	36309-36311	IN	denotes	of
T32149	36312-36317	NN	denotes	Dmrt7
T32150	36318-36324	NN	denotes	mutant
T32151	36330-36334	NN	denotes	cell
T32152	36325-36329	NN	denotes	germ
T32153	36335-36342	VBG	denotes	showing
T32154	36343-36349	JJ	denotes	normal
T32155	36371-36381	NN	denotes	morphology
T32156	36350-36359	NN	denotes	diplotene
T32157	36360-36370	NN	denotes	chromosome
T32158	36382-36385	CC	denotes	and
T32159	36386-36398	VBN	denotes	internalized
T32160	36402-36406	NN	denotes	body
T32161	36399-36401	NN	denotes	XY
T32162	36406-36408	,	denotes	,
T32163	36408-36411	CC	denotes	but
T32164	36412-36414	DT	denotes	no
T32165	36420-36432	NN	denotes	accumulation
T32166	36415-36419	NN	denotes	HP1β
T32167	36433-36435	IN	denotes	in
T32168	36436-36439	DT	denotes	the
T32169	36443-36447	NN	denotes	body
T32170	36440-36442	NN	denotes	XY
T32171	36447-36448	.	denotes	.
T32172	36448-36492	sentence	denotes	XY chromosome pairs are indicated by arrow.
T32173	36449-36451	NN	denotes	XY
T32174	36463-36468	NNS	denotes	pairs
T32175	36452-36462	NN	denotes	chromosome
T32176	36473-36482	VBN	denotes	indicated
T32177	36469-36472	VBP	denotes	are
T32178	36483-36485	IN	denotes	by
T32179	36486-36491	NN	denotes	arrow
T32180	36491-36492	.	denotes	.
T814	0-1	DT	denotes	A
T815	28-35	NN	denotes	Homolog
T13185	24277-24285	NN	denotes	proteins
T13186	24295-24301	JJ	denotes	normal
T10048	17188-17202	JJ	denotes	multinucleated
T10049	17203-17208	NNS	denotes	cells
T10050	17209-17212	CC	denotes	and
T6854	10030-10035	NN	denotes	Dmrt7
T6855	10046-10048	,	denotes	,
T17576	31699-31707	RB	denotes	normally
T17577	31718-31720	IN	denotes	to
R6382	T23792	T23791	prep	of,Generation
R6383	T23793	T23794	compound	Dmrt7,mice
R6384	T23794	T23792	pobj	mice,of
R6385	T23795	T23791	punct	.,Generation
R6386	T23797	T23798	det	A,fragment
R6387	T23798	T23802	nsubjpass	fragment,used
R6388	T23799	T23798	compound	mouse,fragment
R6389	T23800	T23801	compound	Dmrt7,cDNA
R6390	T23801	T23798	compound	cDNA,fragment
R6391	T23803	T23798	acl	containing,fragment
R6392	T23804	T23803	dobj	sequences,containing
R6393	T23805	T23804	prep	from,sequences
R6394	T23806	T23805	pobj	exon,from
R6395	T23807	T23806	nummod	8,exon
R6396	T23808	T23802	auxpass	was,used
R6397	T23809	T23810	aux	to,screen
R6398	T23810	T23802	advcl	screen,used
R6399	T23811	T23812	det	a,library
R6400	T23812	T23810	dobj	library,screen
R6401	T23813	T23812	compound	mouse,library
R6402	T23814	T23812	compound	BAC,library
R6403	T23815	T23812	prep	from,library
R6404	T23816	T23817	det	the,strain
R6405	T23817	T23815	pobj	strain,from
R6406	T23818	T23819	nummod	129,SvJ
R6407	T23819	T23817	compound	SvJ,strain
R6408	T23820	T23819	punct	/,SvJ
R6409	T23821	T23822	punct	(,Stratagene
R6410	T23822	T23802	parataxis	Stratagene,used
R6411	T23823	T23822	punct	", ",Stratagene
R6412	T23824	T23822	npadvmod	http://www.stratagene.com,Stratagene
R6413	T23825	T23822	punct	),Stratagene
R6414	T23826	T23802	punct	", ",used
R6415	T23827	T23802	cc	and,used
R6416	T23828	T23829	nsubjpass	clones,isolated
R6417	T23829	T23802	conj	isolated,used
R6418	T23830	T23828	acl	containing,clones
R6419	T23831	T23832	compound	promoter,sequences
R6420	T23832	T23830	dobj	sequences,containing
R6421	T23833	T23829	auxpass	were,isolated
R6422	T23834	T23829	cc	and,isolated
R6423	T23835	T23829	conj	sequenced,isolated
R6424	T23836	T23837	aux	to,obtain
R6425	T23837	T23835	advcl	obtain,sequenced
R6426	T23838	T23839	nmod	Dmrt7,sequence
R6427	T23839	T23837	dobj	sequence,obtain
R6428	T23840	T23839	amod	genomic,sequence
R6429	T23841	T23829	punct	.,isolated
R6430	T23843	T23844	det	The,vector
R6431	T23844	T23846	nsubjpass	vector,constructed
R6432	T23845	T23844	compound	targeting,vector
R6433	T23846	T23855	ccomp	constructed,used
R6434	T23847	T23844	appos	pDZ169,vector
R6435	T23848	T23844	punct	(,vector
R6436	T23849	T23844	acl	diagrammed,vector
R6437	T23850	T23849	prep	in,diagrammed
R6438	T23851	T23852	compound	Figure,S2
R6439	T23852	T23850	pobj	S2,in
R6440	T23853	T23844	punct	),vector
R6441	T23854	T23846	auxpass	was,constructed
R6442	T23856	T23846	prep	by,constructed
R6443	T23857	T23858	det	the,scheme
R6444	T23858	T23856	pobj	scheme,by
R6445	T23859	T23858	amod	following,scheme
R6446	T23860	T23855	punct	: ,used
R6447	T23861	T23862	det	The,pDZ157
R6448	T23862	T23855	nsubjpass	pDZ157,used
R6449	T23863	T23862	compound	vector,pDZ157
R6450	T23864	T23855	auxpass	was,used
R6451	T23865	T23855	prep	as,used
R6452	T23866	T23867	det	a,vector
R6453	T23867	T23865	pobj	vector,as
R6454	T23868	T23867	compound	backbone,vector
R6455	T23869	T23870	punct	[,31
R6456	T23870	T23855	parataxis	31,used
R6457	T23871	T23870	punct	],31
R6458	T23872	T23855	punct	.,used
R6459	T23874	T23875	npadvmod	3,inserted
R6460	T23876	T23874	punct	′,3
R6461	T23877	T23874	prep	to,3
R6462	T23878	T23879	compound	Pgk,neo
R6463	T23879	T23877	pobj	neo,to
R6464	T23880	T23879	punct	-,neo
R6465	T23881	T23879	cc	and,neo
R6466	T23882	T23883	det	the,site
R6467	T23883	T23879	conj	site,neo
R6468	T23884	T23883	compound	loxP,site
R6469	T23885	T23875	punct	", ",inserted
R6470	T23886	T23875	nsubj	we,inserted
R6471	T23887	T23875	punct	", ",inserted
R6472	T23888	T23875	prep	as,inserted
R6473	T23889	T23890	det	a,fragment
R6474	T23890	T23888	pobj	fragment,as
R6475	T23891	T23892	compound	XmaI,XmaI
R6476	T23892	T23890	compound	XmaI,fragment
R6477	T23893	T23892	punct	/,XmaI
R6478	T23894	T23890	compound	DNA,fragment
R6479	T23895	T23875	punct	", ",inserted
R6480	T23896	T23897	det	the,intron
R6481	T23897	T23875	dobj	intron,inserted
R6482	T23898	T23897	amod	third,intron
R6483	T23899	T23897	prep	of,intron
R6484	T23900	T23899	pobj	Dmrt7,of
R6485	T23901	T23902	punct	(,downstream
R6486	T23902	T23900	parataxis	downstream,Dmrt7
R6487	T23903	T23902	prep	from,downstream
R6488	T23904	T23905	nummod	366,bp
R6489	T23905	T23903	pobj	bp,from
R6490	T23906	T23903	prep	to,from
R6491	T23907	T23908	nummod	"2,773",bp
R6492	T23908	T23906	pobj	bp,to
R6493	T23909	T23902	prep	of,downstream
R6494	T23910	T23909	pobj	exon,of
R6495	T23911	T23910	nummod	3,exon
R6496	T23912	T23902	punct	),downstream
R6497	T23913	T23897	acl	generated,intron
R6498	T23914	T23913	prep	by,generated
R6499	T23915	T23914	pobj	PCR,by
R6500	T23916	T23875	punct	.,inserted
R6501	T23918	T23919	npadvmod	5,inserted
R6502	T23920	T23918	punct	′,5
R6503	T23921	T23918	prep	to,5
R6504	T23922	T23923	compound	Pgk,neo
R6505	T23923	T23921	pobj	neo,to
R6506	T23924	T23923	punct	-,neo
R6507	T23925	T23919	punct	", ",inserted
R6508	T23926	T23919	nsubj	we,inserted
R6509	T23927	T23928	det	an,fragment
R6510	T23928	T23919	dobj	fragment,inserted
R6511	T23929	T23930	compound	EcoRI,NotI
R6512	T23930	T23928	compound	NotI,fragment
R6513	T23931	T23930	punct	/,NotI
R6514	T23932	T23928	compound	PCR,fragment
R6515	T23933	T23928	acl	extending,fragment
R6516	T23934	T23933	prep	from,extending
R6517	T23935	T23936	nummod	"4,107",bp
R6518	T23936	T23934	pobj	bp,from
R6519	T23937	T23934	prep	to,from
R6520	T23938	T23939	nummod	336,bp
R6521	T23939	T23937	pobj	bp,to
R6522	T23940	T23933	npadvmod	5,extending
R6523	T23941	T23940	punct	′,5
R6524	T23942	T23940	prep	of,5
R6525	T23943	T23944	det	the,start
R6526	T23944	T23942	pobj	start,of
R6527	T23945	T23944	nmod	Dmrt7,start
R6528	T23946	T23944	amod	translational,start
R6529	T23947	T23919	punct	.,inserted
R6530	T23949	T23950	advmod	Finally,inserted
R6531	T23951	T23950	punct	", ",inserted
R6532	T23952	T23950	nsubj	we,inserted
R6533	T23953	T23954	det	a,site
R6534	T23954	T23950	dobj	site,inserted
R6535	T23955	T23954	compound	loxP,site
R6536	T23956	T23954	cc	and,site
R6537	T23957	T23958	compound	NotI,site
R6538	T23958	T23954	conj	site,site
R6539	T23959	T23960	nummod	336,bp
R6540	T23960	T23950	npadvmod	bp,inserted
R6541	T23961	T23960	nummod	5,bp
R6542	T23962	T23960	punct	′,bp
R6543	T23963	T23960	prep	of,bp
R6544	T23964	T23965	det	the,start
R6545	T23965	T23963	pobj	start,of
R6546	T23966	T23965	nmod	Dmrt7,start
R6547	T23967	T23965	amod	translational,start
R6548	T23968	T23950	punct	.,inserted
R6549	T23970	T23971	prep	In,flanked
R6550	T23972	T23973	det	the,vector
R6551	T23973	T23970	pobj	vector,In
R6552	T23974	T23973	amod	resulting,vector
R6553	T23975	T23971	punct	", ",flanked
R6554	T23976	T23977	det	the,exons
R6555	T23977	T23971	nsubjpass	exons,flanked
R6556	T23978	T23977	amod	second,exons
R6557	T23979	T23978	cc	and,second
R6558	T23980	T23978	conj	third,second
R6559	T23981	T23977	prep	of,exons
R6560	T23982	T23981	pobj	Dmrt7,of
R6561	T23983	T23971	auxpass	are,flanked
R6562	T23984	T23971	agent	by,flanked
R6563	T23985	T23986	compound	loxP,sites
R6564	T23986	T23984	pobj	sites,by
R6565	T23987	T23988	punct	(,floxed
R6566	T23988	T23986	parataxis	floxed,sites
R6567	T23989	T23988	punct	),floxed
R6568	T23990	T23971	punct	.,flanked
R6569	T23992	T23993	det	The,portions
R6570	T23993	T23997	nsubjpass	portions,sequenced
R6571	T23994	T23995	npadvmod	Dmrt7,containing
R6572	T23995	T23993	amod	containing,portions
R6573	T23996	T23995	punct	-,containing
R6574	T23998	T23993	prep	of,portions
R6575	T23999	T23998	pobj	pDZ169,of
R6576	T24000	T23997	auxpass	were,sequenced
R6577	T24001	T23997	advmod	completely,sequenced
R6578	T24002	T23997	punct	.,sequenced
R6579	T24004	T24005	nsubjpass	pDZ169,linearized
R6580	T24006	T24005	auxpass	was,linearized
R6581	T24007	T24005	prep	with,linearized
R6582	T24008	T24007	pobj	PmeI,with
R6583	T24009	T24005	cc	and,linearized
R6584	T24010	T24005	conj	electroporated,linearized
R6585	T24011	T24010	prep	into,electroporated
R6586	T24012	T24013	compound	CJ7,cells
R6587	T24013	T24011	pobj	cells,into
R6588	T24014	T24013	compound	ES,cells
R6589	T24015	T24013	punct	(,cells
R6590	T24016	T24017	advmod	originally,derived
R6591	T24017	T24013	acl	derived,cells
R6592	T24018	T24017	prep	from,derived
R6593	T24019	T24020	det	the,strain
R6594	T24020	T24018	pobj	strain,from
R6595	T24021	T24020	compound	129S1,strain
R6596	T24022	T24013	punct	),cells
R6597	T24023	T24005	punct	.,linearized
R6598	T24025	T24026	nummod	Three,recombinants
R6599	T24026	T24028	nsubjpass	recombinants,identified
R6600	T24027	T24026	amod	homologous,recombinants
R6601	T24029	T24028	auxpass	were,identified
R6602	T24030	T24028	prep	from,identified
R6603	T24031	T24032	nummod	296,colonies
R6604	T24032	T24030	pobj	colonies,from
R6605	T24033	T24034	npadvmod	G418,resistant
R6606	T24034	T24032	amod	resistant,colonies
R6607	T24035	T24034	punct	-,resistant
R6608	T24036	T24028	prep	by,identified
R6609	T24037	T24038	compound	Southern,hybridization
R6610	T24038	T24036	pobj	hybridization,by
R6611	T24039	T24028	prep	by,identified
R6612	T24040	T24039	pobj	use,by
R6613	T24041	T24040	prep	of,use
R6614	T24042	T24043	det	a,probe
R6615	T24043	T24041	pobj	probe,of
R6616	T24044	T24043	compound	DNA,probe
R6617	T24045	T24043	prep	from,probe
R6618	T24046	T24047	det	the,sequences
R6619	T24047	T24045	pobj	sequences,from
R6620	T24048	T24047	advmod	upstream,sequences
R6621	T24049	T24048	prep	of,upstream
R6622	T24050	T24049	pobj	exon,of
R6623	T24051	T24050	nummod	1,exon
R6624	T24052	T24053	aux	to,screen
R6625	T24053	T24028	advcl	screen,identified
R6626	T24054	T24055	amod	genomic,DNA
R6627	T24055	T24053	dobj	DNA,screen
R6628	T24056	T24055	acl	digested,DNA
R6629	T24057	T24056	prep	with,digested
R6630	T24058	T24057	pobj	EcoRI,with
R6631	T24059	T24028	punct	.,identified
R6632	T24061	T24062	amod	Homologous,recombination
R6633	T24062	T24063	nsubjpass	recombination,confirmed
R6634	T24064	T24063	auxpass	was,confirmed
R6635	T24065	T24063	prep	on,confirmed
R6636	T24066	T24067	det	both,ends
R6637	T24067	T24065	pobj	ends,on
R6638	T24068	T24067	prep	of,ends
R6639	T24069	T24070	det	the,region
R6640	T24070	T24068	pobj	region,of
R6641	T24071	T24070	amod	targeted,region
R6642	T24072	T24063	prep	by,confirmed
R6643	T24073	T24074	compound	Southern,hybridization
R6644	T24074	T24072	pobj	hybridization,by
R6645	T24075	T24063	punct	.,confirmed
R6646	T24077	T24078	nsubjpass	Probes,made
R6647	T24079	T24077	prep	for,Probes
R6648	T24080	T24081	compound	Southern,hybridization
R6649	T24081	T24079	pobj	hybridization,for
R6650	T24082	T24078	auxpass	were,made
R6651	T24083	T24078	prep	by,made
R6652	T24084	T24083	pobj	PCR,by
R6653	T24085	T24078	advcl	using,made
R6654	T24086	T24087	compound	primers,DM5S11
R6655	T24087	T24085	dobj	DM5S11,using
R6656	T24088	T24087	compound	DM5S10,DM5S11
R6657	T24089	T24087	punct	/,DM5S11
R6658	T24090	T24091	punct	(,probe
R6659	T24091	T24087	parataxis	probe,DM5S11
R6660	T24092	T24091	nummod	5,probe
R6661	T24093	T24092	punct	′,5
R6662	T24094	T24091	punct	),probe
R6663	T24095	T24087	cc	and,DM5S11
R6664	T24096	T24097	compound	DM5PR1,DM5PR2
R6665	T24097	T24087	conj	DM5PR2,DM5S11
R6666	T24098	T24097	punct	/,DM5PR2
R6667	T24099	T24100	punct	(,probe
R6668	T24100	T24097	parataxis	probe,DM5PR2
R6669	T24101	T24100	nummod	3,probe
R6670	T24102	T24101	punct	′,3
R6671	T24103	T24100	punct	),probe
R6672	T24104	T24087	punct	", ",DM5S11
R6673	T24105	T24087	acl	listed,DM5S11
R6674	T24106	T24105	advmod	below,listed
R6675	T24107	T24078	punct	.,made
R6676	T24109	T24110	nummod	Two,clones
R6677	T24110	T24114	nsubjpass	clones,injected
R6678	T24111	T24110	amod	targeted,clones
R6679	T24112	T24113	compound	ES,cell
R6680	T24113	T24110	compound	cell,clones
R6681	T24115	T24110	acl	containing,clones
R6682	T24116	T24117	det	the,allele
R6683	T24117	T24115	dobj	allele,containing
R6684	T24118	T24117	amod	floxed,allele
R6685	T24119	T24117	appos	Dmrt7neo,allele
R6686	T24120	T24114	auxpass	were,injected
R6687	T24121	T24114	prep	into,injected
R6688	T24122	T24123	nmod	C57Bl,blastocysts
R6689	T24123	T24121	pobj	blastocysts,into
R6690	T24124	T24122	punct	/,C57Bl
R6691	T24125	T24122	nummod	6,C57Bl
R6692	T24126	T24127	aux	to,generate
R6693	T24127	T24114	advcl	generate,injected
R6694	T24128	T24127	dobj	chimeras,generate
R6695	T24129	T24114	punct	.,injected
R6696	T24131	T24132	amod	Chimeric,males
R6697	T24132	T24133	nsubjpass	males,bred
R6698	T24134	T24133	auxpass	were,bred
R6699	T24135	T24133	prep	with,bred
R6700	T24136	T24137	nmod	C57Bl,females
R6701	T24137	T24135	pobj	females,with
R6702	T24138	T24136	punct	/,C57Bl
R6703	T24139	T24136	nummod	6,C57Bl
R6704	T24140	T24141	aux	to,generate
R6705	T24141	T24133	advcl	generate,bred
R6706	T24142	T24141	dobj	heterozygotes,generate
R6707	T24143	T24142	acl	carrying,heterozygotes
R6708	T24144	T24143	dobj	Dmrt7neo,carrying
R6709	T24145	T24133	punct	.,bred
R6710	T24147	T24148	nmod	Dmrt7,females
R6711	T24148	T24152	nsubjpass	females,bred
R6712	T24149	T24147	punct	+,Dmrt7
R6713	T24150	T24147	punct	/,Dmrt7
R6714	T24151	T24147	appos	Dmrt7neo,Dmrt7
R6715	T24153	T24152	auxpass	were,bred
R6716	T24154	T24152	prep	with,bred
R6717	T24155	T24156	amod	male,mice
R6718	T24156	T24154	pobj	mice,with
R6719	T24157	T24158	compound	β,actin
R6720	T24158	T24160	compound	actin,Cre
R6721	T24159	T24158	punct	-,actin
R6722	T24160	T24162	npadvmod	Cre,transgenic
R6723	T24161	T24160	punct	-,Cre
R6724	T24162	T24156	amod	transgenic,mice
R6725	T24163	T24164	aux	to,delete
R6726	T24164	T24152	advcl	delete,bred
R6727	T24165	T24166	det	the,sequences
R6728	T24166	T24164	dobj	sequences,delete
R6729	T24167	T24166	amod	floxed,sequences
R6730	T24168	T24164	cc	and,delete
R6731	T24169	T24164	conj	generate,delete
R6732	T24170	T24171	amod	heterozygous,mutants
R6733	T24171	T24169	dobj	mutants,generate
R6734	T24172	T24171	nmod	Dmrt7,mutants
R6735	T24173	T24172	punct	−,Dmrt7
R6736	T24174	T24172	punct	/,Dmrt7
R6737	T24175	T24172	punct	+,Dmrt7
R6738	T24176	T24171	compound	deletion,mutants
R6739	T24177	T24171	punct	", ",mutants
R6740	T24178	T24179	dep	which,interbred
R6741	T24179	T24171	relcl	interbred,mutants
R6742	T24180	T24179	auxpass	were,interbred
R6743	T24181	T24182	aux	to,generate
R6744	T24182	T24179	advcl	generate,interbred
R6745	T24183	T24184	amod	homozygous,mutants
R6746	T24184	T24182	dobj	mutants,generate
R6747	T24185	T24184	nmod	Dmrt7,mutants
R6748	T24186	T24185	punct	−,Dmrt7
R6749	T24187	T24185	punct	/,Dmrt7
R6750	T24188	T24185	punct	−,Dmrt7
R6751	T24189	T24152	punct	.,bred
R6752	T24487	T24486	cc	and,Genotyping
R6753	T24488	T24489	compound	RT,PCR
R6754	T24489	T24486	conj	PCR,Genotyping
R6755	T24490	T24489	punct	-,PCR
R6756	T24491	T24489	punct	.,PCR
R6757	T24493	T24494	prep	For,amplified
R6758	T24495	T24493	pobj	genotyping,For
R6759	T24496	T24494	punct	", ",amplified
R6760	T24497	T24498	compound	tail,clip
R6761	T24498	T24500	compound	clip,DNA
R6762	T24499	T24498	punct	-,clip
R6763	T24500	T24494	nsubjpass	DNA,amplified
R6764	T24501	T24494	auxpass	was,amplified
R6765	T24502	T24494	prep	for,amplified
R6766	T24503	T24504	nummod	35,cycles
R6767	T24504	T24502	pobj	cycles,for
R6768	T24505	T24494	punct	.,amplified
R6769	T24507	T24508	amod	Chromosomal,sex
R6770	T24508	T24509	nsubjpass	sex,determined
R6771	T24510	T24509	auxpass	was,determined
R6772	T24511	T24509	prep	by,determined
R6773	T24512	T24511	pobj	PCR,by
R6774	T24513	T24509	prep	with,determined
R6775	T24514	T24513	pobj	primers,with
R6776	T24515	T24514	prep	to,primers
R6777	T24516	T24517	det	the,gene
R6778	T24517	T24515	pobj	gene,to
R6779	T24518	T24519	compound	Y,chromosome
R6780	T24519	T24517	compound	chromosome,gene
R6781	T24520	T24517	appos	Zfy,gene
R6782	T24521	T24522	punct	(,below
R6783	T24522	T24509	parataxis	below,determined
R6784	T24523	T24522	punct	),below
R6785	T24524	T24509	punct	.,determined
R6786	T24526	T24527	det	The,allele
R6787	T24527	T24532	nsubjpass	allele,detected
R6788	T24528	T24529	amod	wild,type
R6789	T24529	T24527	compound	type,allele
R6790	T24530	T24529	punct	-,type
R6791	T24531	T24527	compound	Dmrt7,allele
R6792	T24533	T24527	appos	Dmrt7,allele
R6793	T24534	T24533	punct	+,Dmrt7
R6794	T24535	T24532	auxpass	was,detected
R6795	T24536	T24532	prep	by,detected
R6796	T24537	T24536	pobj	PCR,by
R6797	T24538	T24532	prep	with,detected
R6798	T24539	T24540	compound	DM5S4,DM5S5
R6799	T24540	T24538	pobj	DM5S5,with
R6800	T24541	T24540	punct	/,DM5S5
R6801	T24542	T24532	punct	", ",detected
R6802	T24543	T24532	prep	with,detected
R6803	T24544	T24545	det	an,temperature
R6804	T24545	T24543	pobj	temperature,with
R6805	T24546	T24545	amod	annealing,temperature
R6806	T24547	T24545	prep	of,temperature
R6807	T24548	T24549	nummod	60,°C
R6808	T24549	T24547	pobj	°C,of
R6809	T24550	T24532	punct	.,detected
R6810	T24552	T24553	det	The,allele
R6811	T24553	T24555	nsubjpass	allele,detected
R6812	T24554	T24553	compound	Dmrt7flox,allele
R6813	T24556	T24555	auxpass	was,detected
R6814	T24557	T24555	prep	by,detected
R6815	T24558	T24557	pobj	PCR,by
R6816	T24559	T24555	prep	with,detected
R6817	T24560	T24561	compound	DM5S5F,DM7KO7R
R6818	T24561	T24559	pobj	DM7KO7R,with
R6819	T24562	T24561	punct	/,DM7KO7R
R6820	T24563	T24555	prep	with,detected
R6821	T24564	T24565	det	an,temperature
R6822	T24565	T24563	pobj	temperature,with
R6823	T24566	T24565	amod	annealing,temperature
R6824	T24567	T24565	prep	of,temperature
R6825	T24568	T24569	nummod	62,°C
R6826	T24569	T24567	pobj	°C,of
R6827	T24570	T24555	punct	.,detected
R6828	T24572	T24573	det	The,allele
R6829	T24573	T24576	nsubjpass	allele,detected
R6830	T24574	T24573	amod	deleted,allele
R6831	T24575	T24573	compound	Dmrt7,allele
R6832	T24577	T24573	appos	Dmrt7,allele
R6833	T24578	T24577	punct	−,Dmrt7
R6834	T24579	T24576	auxpass	was,detected
R6835	T24580	T24576	prep	with,detected
R6836	T24581	T24582	compound	DM5S3,DM7KO7R
R6837	T24582	T24580	pobj	DM7KO7R,with
R6838	T24583	T24582	punct	/,DM7KO7R
R6839	T24584	T24576	prep	with,detected
R6840	T24585	T24586	det	an,temperature
R6841	T24586	T24584	pobj	temperature,with
R6842	T24587	T24586	amod	annealing,temperature
R6843	T24588	T24586	prep	of,temperature
R6844	T24589	T24590	nummod	62,°C
R6845	T24590	T24588	pobj	°C,of
R6846	T24591	T24576	punct	.,detected
R6847	T24593	T24594	compound	RT,PCR
R6848	T24594	T24596	nsubj	PCR,was
R6849	T24595	T24594	punct	-,PCR
R6850	T24597	T24594	prep	for,PCR
R6851	T24598	T24599	compound	Dmrt7,expression
R6852	T24599	T24600	compound	expression,analysis
R6853	T24600	T24597	pobj	analysis,for
R6854	T24601	T24602	mark	as,described
R6855	T24602	T24596	advcl	described,was
R6856	T24603	T24604	punct	[,23
R6857	T24604	T24602	parataxis	23,described
R6858	T24605	T24604	punct	],23
R6859	T24606	T24596	advcl	using,was
R6860	T24607	T24608	compound	primers,SK112
R6861	T24608	T24606	dobj	SK112,using
R6862	T24609	T24608	compound	SK111,SK112
R6863	T24610	T24608	punct	/,SK112
R6864	T24611	T24606	prep	with,using
R6865	T24612	T24613	det	an,temperature
R6866	T24613	T24611	pobj	temperature,with
R6867	T24614	T24613	compound	annealing,temperature
R6868	T24615	T24613	prep	of,temperature
R6869	T24616	T24617	nummod	62,°C
R6870	T24617	T24615	pobj	°C,of
R6871	T24618	T24596	punct	.,was
R6872	T24841	T24840	punct	.,Primers
R6873	T24844	T24843	punct	: ,DM5S3
R6874	T24845	T24846	nummod	5,AGAGTGGATTGAATCGGATAGCTC
R6875	T24846	T24843	appos	AGAGTGGATTGAATCGGATAGCTC,DM5S3
R6876	T24847	T24845	punct	′,5
R6877	T24848	T24846	punct	-,AGAGTGGATTGAATCGGATAGCTC
R6878	T24849	T24846	punct	-,AGAGTGGATTGAATCGGATAGCTC
R6879	T24850	T24846	nummod	3,AGAGTGGATTGAATCGGATAGCTC
R6880	T24851	T24846	punct	′,AGAGTGGATTGAATCGGATAGCTC
R6881	T24854	T24853	punct	: ,DM5S4
R6882	T24855	T24856	nummod	5,AGGATCTTAGTGTCGAATGAATAC
R6883	T24856	T24853	appos	AGGATCTTAGTGTCGAATGAATAC,DM5S4
R6884	T24857	T24855	punct	′,5
R6885	T24858	T24856	punct	-,AGGATCTTAGTGTCGAATGAATAC
R6886	T24859	T24856	punct	-,AGGATCTTAGTGTCGAATGAATAC
R6887	T24860	T24856	nummod	3,AGGATCTTAGTGTCGAATGAATAC
R6888	T24861	T24856	punct	′,AGGATCTTAGTGTCGAATGAATAC
R6889	T24864	T24863	punct	: ,DM5S5
R6890	T24865	T24866	nummod	5,CCCTTATCCTCCTGCATCCAGATC
R6891	T24866	T24863	appos	CCCTTATCCTCCTGCATCCAGATC,DM5S5
R6892	T24867	T24865	punct	′,5
R6893	T24868	T24866	punct	-,CCCTTATCCTCCTGCATCCAGATC
R6894	T24869	T24866	punct	-,CCCTTATCCTCCTGCATCCAGATC
R6895	T24870	T24866	nummod	3,CCCTTATCCTCCTGCATCCAGATC
R6896	T24871	T24866	punct	′,CCCTTATCCTCCTGCATCCAGATC
R6897	T24874	T24873	punct	: ,DM5S10
R6898	T24875	T24876	nummod	5,CAGGCTATGGTTAGACTTGAGCAC
R6899	T24876	T24873	appos	CAGGCTATGGTTAGACTTGAGCAC,DM5S10
R6900	T24877	T24875	punct	′,5
R6901	T24878	T24876	punct	-,CAGGCTATGGTTAGACTTGAGCAC
R6902	T24879	T24876	punct	-,CAGGCTATGGTTAGACTTGAGCAC
R6903	T24880	T24876	nummod	3,CAGGCTATGGTTAGACTTGAGCAC
R6904	T24881	T24876	punct	′,CAGGCTATGGTTAGACTTGAGCAC
R6905	T24884	T24883	punct	: ,DM5S11
R6906	T24885	T24886	nummod	5,CATCACTCGCGGACAAAGATGCAG
R6907	T24886	T24883	appos	CATCACTCGCGGACAAAGATGCAG,DM5S11
R6908	T24887	T24885	punct	′,5
R6909	T24888	T24886	punct	-,CATCACTCGCGGACAAAGATGCAG
R6910	T24889	T24886	punct	-,CATCACTCGCGGACAAAGATGCAG
R6911	T24890	T24886	nummod	3,CATCACTCGCGGACAAAGATGCAG
R6912	T24891	T24886	punct	′,CATCACTCGCGGACAAAGATGCAG
R6913	T24894	T24893	punct	: ,DM5PR1
R6914	T24895	T24896	nummod	5,CTTCTGCTACAGCCACAGGTCTGG
R6915	T24896	T24893	appos	CTTCTGCTACAGCCACAGGTCTGG,DM5PR1
R6916	T24897	T24895	punct	′,5
R6917	T24898	T24896	punct	-,CTTCTGCTACAGCCACAGGTCTGG
R6918	T24899	T24896	punct	-,CTTCTGCTACAGCCACAGGTCTGG
R6919	T24900	T24896	nummod	3,CTTCTGCTACAGCCACAGGTCTGG
R6920	T24901	T24896	punct	′,CTTCTGCTACAGCCACAGGTCTGG
R6921	T24904	T24903	punct	: ,DM5PR2
R6922	T24905	T24906	nummod	5,GAATTCAACTAGTATCTGTCCC
R6923	T24906	T24903	appos	GAATTCAACTAGTATCTGTCCC,DM5PR2
R6924	T24907	T24905	punct	′,5
R6925	T24908	T24906	punct	-,GAATTCAACTAGTATCTGTCCC
R6926	T24909	T24906	punct	-,GAATTCAACTAGTATCTGTCCC
R6927	T24910	T24906	nummod	3,GAATTCAACTAGTATCTGTCCC
R6928	T24911	T24906	punct	′,GAATTCAACTAGTATCTGTCCC
R6929	T24914	T24913	punct	: ,DM7KO7R
R6930	T24915	T24916	nummod	5,CGAGGATCAAGCTCAGGTCACTAGG
R6931	T24916	T24913	appos	CGAGGATCAAGCTCAGGTCACTAGG,DM7KO7R
R6932	T24917	T24915	punct	′,5
R6933	T24918	T24916	punct	-,CGAGGATCAAGCTCAGGTCACTAGG
R6934	T24919	T24916	punct	-,CGAGGATCAAGCTCAGGTCACTAGG
R6935	T24920	T24916	nummod	3,CGAGGATCAAGCTCAGGTCACTAGG
R6936	T24921	T24916	punct	′,CGAGGATCAAGCTCAGGTCACTAGG
R6937	T24924	T24923	punct	: ,DM5S5F
R6938	T24925	T24926	nummod	5,GATCTGGATGCAGGAGGATAAGGG
R6939	T24926	T24923	appos	GATCTGGATGCAGGAGGATAAGGG,DM5S5F
R6940	T24927	T24925	punct	′,5
R6941	T24928	T24926	punct	-,GATCTGGATGCAGGAGGATAAGGG
R6942	T24929	T24926	punct	-,GATCTGGATGCAGGAGGATAAGGG
R6943	T24930	T24926	nummod	3,GATCTGGATGCAGGAGGATAAGGG
R6944	T24931	T24926	punct	′,GATCTGGATGCAGGAGGATAAGGG
R6945	T24934	T24933	punct	: ,ZFYF
R6946	T24935	T24936	nummod	5,CCTATTGCATGGACAGCAGTCTTATG
R6947	T24936	T24933	appos	CCTATTGCATGGACAGCAGTCTTATG,ZFYF
R6948	T24937	T24935	punct	′,5
R6949	T24938	T24936	punct	-,CCTATTGCATGGACAGCAGTCTTATG
R6950	T24939	T24936	punct	-,CCTATTGCATGGACAGCAGTCTTATG
R6951	T24940	T24936	nummod	3,CCTATTGCATGGACAGCAGTCTTATG
R6952	T24941	T24936	punct	′,CCTATTGCATGGACAGCAGTCTTATG
R6953	T24944	T24943	punct	: ,ZFYR
R6954	T24945	T24946	nummod	5,GACTAGACATGTTCTTAACATCTGTCC
R6955	T24946	T24943	appos	GACTAGACATGTTCTTAACATCTGTCC,ZFYR
R6956	T24947	T24945	punct	′,5
R6957	T24948	T24946	punct	-,GACTAGACATGTTCTTAACATCTGTCC
R6958	T24949	T24946	punct	-,GACTAGACATGTTCTTAACATCTGTCC
R6959	T24950	T24946	nummod	3,GACTAGACATGTTCTTAACATCTGTCC
R6960	T24951	T24946	punct	′,GACTAGACATGTTCTTAACATCTGTCC
R6961	T24954	T24953	punct	: ,SK111
R6962	T24955	T24956	nummod	5,CCCTTCTGGAAAAGAGAACATAGC
R6963	T24956	T24953	appos	CCCTTCTGGAAAAGAGAACATAGC,SK111
R6964	T24957	T24955	punct	′,5
R6965	T24958	T24956	punct	-,CCCTTCTGGAAAAGAGAACATAGC
R6966	T24959	T24956	punct	-,CCCTTCTGGAAAAGAGAACATAGC
R6967	T24960	T24956	nummod	3,CCCTTCTGGAAAAGAGAACATAGC
R6968	T24961	T24956	punct	′,CCCTTCTGGAAAAGAGAACATAGC
R6969	T24964	T24963	punct	: ,SK112
R6970	T24965	T24966	nummod	5,GCTCCAGGGGCCTGTGGCTGTAGC
R6971	T24966	T24963	appos	GCTCCAGGGGCCTGTGGCTGTAGC,SK112
R6972	T24967	T24965	punct	′,5
R6973	T24968	T24966	punct	-,GCTCCAGGGGCCTGTGGCTGTAGC
R6974	T24969	T24966	punct	-,GCTCCAGGGGCCTGTGGCTGTAGC
R6975	T24970	T24966	nummod	3,GCTCCAGGGGCCTGTGGCTGTAGC
R6976	T24971	T24966	punct	′,GCTCCAGGGGCCTGTGGCTGTAGC
R6977	T24973	T24974	compound	β,actinF
R6978	T24975	T24974	punct	-,actinF
R6979	T24976	T24974	punct	: ,actinF
R6980	T24977	T24978	nummod	5,TGCGTGACATCAAAGAGAAG
R6981	T24978	T24974	appos	TGCGTGACATCAAAGAGAAG,actinF
R6982	T24979	T24977	punct	′,5
R6983	T24980	T24978	punct	-,TGCGTGACATCAAAGAGAAG
R6984	T24981	T24978	punct	-,TGCGTGACATCAAAGAGAAG
R6985	T24982	T24978	nummod	3,TGCGTGACATCAAAGAGAAG
R6986	T24983	T24978	punct	′,TGCGTGACATCAAAGAGAAG
R6987	T24985	T24986	compound	β,actinR
R6988	T24987	T24986	punct	-,actinR
R6989	T24988	T24986	punct	: ,actinR
R6990	T24989	T24990	nummod	5,GATGCCACAGGATTCCATA
R6991	T24990	T24986	appos	GATGCCACAGGATTCCATA,actinR
R6992	T24991	T24989	punct	′,5
R6993	T24992	T24990	punct	-,GATGCCACAGGATTCCATA
R6994	T24993	T24990	punct	-,GATGCCACAGGATTCCATA
R6995	T24994	T24990	nummod	3,GATGCCACAGGATTCCATA
R6996	T24995	T24990	punct	′,GATGCCACAGGATTCCATA
R6997	T25223	T25224	amod	Histological,analysis
R6998	T25225	T25224	cc	and,analysis
R6999	T25226	T25227	compound	TUNEL,assay
R7000	T25227	T25224	conj	assay,analysis
R7001	T25228	T25227	punct	.,assay
R7002	T25230	T25231	amod	Dissected,testes
R7003	T25231	T25232	nsubjpass	testes,fixed
R7004	T25233	T25232	auxpass	were,fixed
R7005	T25234	T25232	prep	in,fixed
R7006	T25235	T25236	poss	Bouin,fixative
R7007	T25236	T25234	pobj	fixative,in
R7008	T25237	T25235	case	's,Bouin
R7009	T25238	T25236	cc	or,fixative
R7010	T25239	T25240	npadvmod	phosphate,buffered
R7011	T25240	T25242	amod	buffered,formalin
R7012	T25241	T25240	punct	-,buffered
R7013	T25242	T25236	conj	formalin,fixative
R7014	T25243	T25232	advmod	overnight,fixed
R7015	T25244	T25232	prep	at,fixed
R7016	T25245	T25246	nummod	4,°C
R7017	T25246	T25244	pobj	°C,at
R7018	T25247	T25232	punct	", ",fixed
R7019	T25248	T25249	advmod	progressively,dehydrated
R7020	T25249	T25232	conj	dehydrated,fixed
R7021	T25250	T25249	prep	in,dehydrated
R7022	T25251	T25252	det	a,series
R7023	T25252	T25250	pobj	series,in
R7024	T25253	T25252	amod	graded,series
R7025	T25254	T25252	compound	ethanol,series
R7026	T25255	T25249	punct	", ",dehydrated
R7027	T25256	T25249	cc	and,dehydrated
R7028	T25257	T25249	conj	embedded,dehydrated
R7029	T25258	T25257	prep	in,embedded
R7030	T25259	T25260	compound	paraffin,wax
R7031	T25260	T25258	pobj	wax,in
R7032	T25261	T25232	punct	.,fixed
R7033	T25263	T25264	nsubjpass	Sections,deparaffinized
R7034	T25265	T25266	punct	(,μm
R7035	T25266	T25263	parataxis	μm,Sections
R7036	T25267	T25266	nummod	6,μm
R7037	T25268	T25266	punct	),μm
R7038	T25269	T25264	auxpass	were,deparaffinized
R7039	T25270	T25264	punct	", ",deparaffinized
R7040	T25271	T25264	conj	rehydrated,deparaffinized
R7041	T25272	T25271	punct	", ",rehydrated
R7042	T25273	T25271	cc	and,rehydrated
R7043	T25274	T25271	conj	stained,rehydrated
R7044	T25275	T25274	prep	with,stained
R7045	T25276	T25275	pobj	hematoxylin,with
R7046	T25277	T25276	cc	and,hematoxylin
R7047	T25278	T25276	conj	eosin,hematoxylin
R7048	T25279	T25264	punct	.,deparaffinized
R7049	T25281	T25282	prep	For,treated
R7050	T25283	T25284	compound	TUNEL,analyses
R7051	T25284	T25281	pobj	analyses,For
R7052	T25285	T25282	punct	", ",treated
R7053	T25286	T25287	amod	deparaffinized,sections
R7054	T25287	T25282	nsubjpass	sections,treated
R7055	T25288	T25282	auxpass	were,treated
R7056	T25289	T25282	prep	with,treated
R7057	T25290	T25291	compound	proteinase,K
R7058	T25291	T25289	pobj	K,with
R7059	T25292	T25282	prep	for,treated
R7060	T25293	T25294	nummod	15,min
R7061	T25294	T25292	pobj	min,for
R7062	T25295	T25282	cc	and,treated
R7063	T25296	T25282	conj	quenched,treated
R7064	T25297	T25296	prep	in,quenched
R7065	T25298	T25299	nummod	3.0,%
R7066	T25299	T25300	compound	%,peroxide
R7067	T25300	T25297	pobj	peroxide,in
R7068	T25301	T25300	compound	hydrogen,peroxide
R7069	T25302	T25296	prep	in,quenched
R7070	T25303	T25302	pobj	PBS,in
R7071	T25304	T25296	prep	for,quenched
R7072	T25305	T25306	nummod	5,min
R7073	T25306	T25304	pobj	min,for
R7074	T25307	T25296	prep	at,quenched
R7075	T25308	T25309	compound	room,temperature
R7076	T25309	T25307	pobj	temperature,at
R7077	T25310	T25282	punct	.,treated
R7078	T25312	T25313	advmod	Subsequently,detected
R7079	T25314	T25313	punct	", ",detected
R7080	T25315	T25316	amod	nuclear,staining
R7081	T25316	T25313	nsubjpass	staining,detected
R7082	T25317	T25316	prep	in,staining
R7083	T25318	T25319	amod	apoptotic,cells
R7084	T25319	T25317	pobj	cells,in
R7085	T25320	T25313	auxpass	was,detected
R7086	T25321	T25313	advcl	using,detected
R7087	T25322	T25323	compound	ApopTag,kit
R7088	T25323	T25321	dobj	kit,using
R7089	T25324	T25325	punct	(,Chemicon
R7090	T25325	T25323	parataxis	Chemicon,kit
R7091	T25326	T25325	punct	", ",Chemicon
R7092	T25327	T25325	npadvmod	http://www.chemicon.com,Chemicon
R7093	T25328	T25325	punct	),Chemicon
R7094	T25329	T25321	prep	according,using
R7095	T25330	T25329	prep	to,according
R7096	T25331	T25332	det	the,manufacturer
R7097	T25332	T25333	poss	manufacturer,instructions
R7098	T25333	T25330	pobj	instructions,to
R7099	T25334	T25332	case	's,manufacturer
R7100	T25335	T25313	punct	.,detected
R7101	T25494	T25495	nmod	Tissue,staining
R7102	T25496	T25495	amod	immunofluorescent,staining
R7103	T25497	T25495	punct	.,staining
R7104	T25499	T25500	nsubjpass	Slides,washed
R7105	T25501	T25499	prep	with,Slides
R7106	T25502	T25503	compound	paraffin,sections
R7107	T25503	T25501	pobj	sections,with
R7108	T25504	T25500	auxpass	were,washed
R7109	T25505	T25500	prep	in,washed
R7110	T25506	T25505	pobj	PBT,in
R7111	T25507	T25508	punct	(,Tween
R7112	T25508	T25506	parataxis	Tween,PBT
R7113	T25509	T25510	nummod	0.1,%
R7114	T25510	T25508	compound	%,Tween
R7115	T25511	T25508	nummod	20,Tween
R7116	T25512	T25508	prep	in,Tween
R7117	T25513	T25512	pobj	PBS,in
R7118	T25514	T25508	punct	),Tween
R7119	T25515	T25500	cc	and,washed
R7120	T25516	T25500	conj	autoclaved,washed
R7121	T25517	T25516	prep	in,autoclaved
R7122	T25518	T25519	nummod	10,mM
R7123	T25519	T25520	nmod	mM,acid
R7124	T25520	T25517	pobj	acid,in
R7125	T25521	T25520	amod	citric,acid
R7126	T25522	T25523	punct	(,pH
R7127	T25523	T25520	parataxis	pH,acid
R7128	T25524	T25523	nummod	6.0,pH
R7129	T25525	T25523	punct	),pH
R7130	T25526	T25527	aux	to,retrieve
R7131	T25527	T25516	advcl	retrieve,autoclaved
R7132	T25528	T25527	dobj	antigenicity,retrieve
R7133	T25529	T25500	punct	.,washed
R7134	T25531	T25532	nsubjpass	Slides,blocked
R7135	T25533	T25532	auxpass	were,blocked
R7136	T25534	T25532	prep	in,blocked
R7137	T25535	T25536	nummod	5,%
R7138	T25536	T25537	compound	%,serum
R7139	T25537	T25534	pobj	serum,in
R7140	T25538	T25539	punct	(,matched
R7141	T25539	T25537	parataxis	matched,serum
R7142	T25540	T25539	prep	to,matched
R7143	T25541	T25542	det	the,species
R7144	T25542	T25540	pobj	species,to
R7145	T25543	T25542	prep	of,species
R7146	T25544	T25545	det	the,antibody
R7147	T25545	T25543	pobj	antibody,of
R7148	T25546	T25545	amod	secondary,antibody
R7149	T25547	T25539	punct	),matched
R7150	T25548	T25532	prep	in,blocked
R7151	T25549	T25548	pobj	PBS,in
R7152	T25550	T25532	prep	for,blocked
R7153	T25551	T25552	nummod	1,h
R7154	T25552	T25550	pobj	h,for
R7155	T25553	T25532	prep	at,blocked
R7156	T25554	T25555	compound	room,temperature
R7157	T25555	T25553	pobj	temperature,at
R7158	T25556	T25532	cc	and,blocked
R7159	T25557	T25532	conj	incubated,blocked
R7160	T25558	T25557	prep	with,incubated
R7161	T25559	T25560	amod	primary,antibodies
R7162	T25560	T25558	pobj	antibodies,with
R7163	T25561	T25557	advmod	overnight,incubated
R7164	T25562	T25557	prep	at,incubated
R7165	T25563	T25564	nummod	4,°C
R7166	T25564	T25562	pobj	°C,at
R7167	T25565	T25557	prep	prior,incubated
R7168	T25566	T25565	prep	to,prior
R7169	T25567	T25566	pobj	detection,to
R7170	T25568	T25567	prep	with,detection
R7171	T25569	T25570	amod	secondary,antibodies
R7172	T25570	T25568	pobj	antibodies,with
R7173	T25571	T25532	punct	.,blocked
R7174	T26487	T26486	punct	.,Antibodies
R7175	T26489	T26490	nmod	Rabbit,antibodies
R7176	T26490	T26492	nsubjpass	antibodies,raised
R7177	T26491	T26490	amod	polyclonal,antibodies
R7178	T26493	T26490	prep	to,antibodies
R7179	T26494	T26493	pobj	DMRT7,to
R7180	T26495	T26492	auxpass	were,raised
R7181	T26496	T26492	prep	against,raised
R7182	T26497	T26498	det	a,protein
R7183	T26498	T26496	pobj	protein,against
R7184	T26499	T26498	amod	purified,protein
R7185	T26500	T26498	compound	fusion,protein
R7186	T26501	T26498	acl	containing,protein
R7187	T26502	T26503	compound	glutathione,transferase
R7188	T26503	T26501	dobj	transferase,containing
R7189	T26504	T26503	punct	-,transferase
R7190	T26505	T26503	compound	S,transferase
R7191	T26506	T26503	punct	-,transferase
R7192	T26507	T26503	punct	(,transferase
R7193	T26508	T26503	appos	GST,transferase
R7194	T26509	T26503	punct	),transferase
R7195	T26510	T26503	acl	fused,transferase
R7196	T26511	T26510	prep	to,fused
R7197	T26512	T26513	det	the,acids
R7198	T26513	T26511	pobj	acids,to
R7199	T26514	T26515	npadvmod	C,terminal
R7200	T26515	T26513	amod	terminal,acids
R7201	T26516	T26515	punct	-,terminal
R7202	T26517	T26513	nummod	279,acids
R7203	T26518	T26513	compound	amino,acids
R7204	T26519	T26513	prep	of,acids
R7205	T26520	T26519	pobj	DMRT7,of
R7206	T26521	T26492	punct	.,raised
R7207	T26523	T26524	nsubjpass	Antibodies,removed
R7208	T26525	T26523	prep	to,Antibodies
R7209	T26526	T26525	pobj	GST,to
R7210	T26527	T26524	auxpass	were,removed
R7211	T26528	T26524	prep	by,removed
R7212	T26529	T26530	nmod	GST,affigel
R7213	T26530	T26532	nmod	affigel,chromatography
R7214	T26531	T26530	punct	-,affigel
R7215	T26532	T26528	pobj	chromatography,by
R7216	T26533	T26530	nummod	10,affigel
R7217	T26534	T26524	cc	and,removed
R7218	T26535	T26536	det	the,antiserum
R7219	T26536	T26537	nsubjpass	antiserum,purified
R7220	T26537	T26524	conj	purified,removed
R7221	T26538	T26537	auxpass	was,purified
R7222	T26539	T26537	advmod	then,purified
R7223	T26540	T26537	prep	by,purified
R7224	T26541	T26542	nmod	GST,DMRT7
R7225	T26542	T26544	nmod	DMRT7,affigel
R7226	T26543	T26542	punct	-,DMRT7
R7227	T26544	T26546	nmod	affigel,chromatography
R7228	T26545	T26544	punct	-,affigel
R7229	T26546	T26540	pobj	chromatography,by
R7230	T26547	T26544	nummod	15,affigel
R7231	T26548	T26537	punct	.,purified
R7232	T26550	T26551	compound	DMRT7,antibody
R7233	T26551	T26552	nsubjpass	antibody,used
R7234	T26553	T26552	auxpass	was,used
R7235	T26554	T26552	prep	at,used
R7236	T26555	T26556	nummod	1,dilution
R7237	T26556	T26554	pobj	dilution,at
R7238	T26557	T26558	punct	:,200
R7239	T26558	T26555	prep	200,1
R7240	T26559	T26552	prep	with,used
R7241	T26560	T26561	det	a,antibody
R7242	T26561	T26559	pobj	antibody,with
R7243	T26562	T26561	nmod	goat,antibody
R7244	T26563	T26561	amod	anti-rabbit,antibody
R7245	T26564	T26561	amod	secondary,antibody
R7246	T26565	T26566	punct	(,Probes
R7247	T26566	T26561	parataxis	Probes,antibody
R7248	T26567	T26566	compound	Molecular,Probes
R7249	T26568	T26566	punct	", ",Probes
R7250	T26569	T26566	npadvmod	http://www.invitrogen.com,Probes
R7251	T26570	T26566	punct	),Probes
R7252	T26571	T26561	prep	at,antibody
R7253	T26572	T26573	nummod	1,dilution
R7254	T26573	T26571	pobj	dilution,at
R7255	T26574	T26575	punct	:,200
R7256	T26575	T26572	prep	200,1
R7257	T26576	T26552	punct	.,used
R7258	T26578	T26579	amod	Other,antibodies
R7259	T26579	T26581	nsubj	antibodies,were
R7260	T26580	T26579	amod	primary,antibodies
R7261	T26582	T26579	acl	used,antibodies
R7262	T26583	T26582	prep	for,used
R7263	T26584	T26583	pobj	immunofluorescence,for
R7264	T26585	T26581	attr	rat,were
R7265	T26586	T26585	amod	anti-GATA1,rat
R7266	T26587	T26588	punct	(,265
R7267	T26588	T26585	parataxis	265,rat
R7268	T26589	T26588	dep	1,265
R7269	T26590	T26591	punct	:,200
R7270	T26591	T26589	prep	200,1
R7271	T26592	T26588	punct	", ",265
R7272	T26593	T26594	compound	Santa,Cruz
R7273	T26594	T26595	compound	Cruz,Biotechnology
R7274	T26595	T26588	dep	Biotechnology,265
R7275	T26596	T26595	punct	", ",Biotechnology
R7276	T26597	T26595	npadvmod	http://www.scbt.com,Biotechnology
R7277	T26598	T26588	punct	", ",265
R7278	T26599	T26588	compound	sc,265
R7279	T26600	T26588	punct	-,265
R7280	T26601	T26588	punct	),265
R7281	T26602	T26585	punct	", ",rat
R7282	T26603	T26585	conj	goat,rat
R7283	T26604	T26603	amod	anti-GATA4,goat
R7284	T26605	T26606	punct	(,sc
R7285	T26606	T26603	parataxis	sc,goat
R7286	T26607	T26606	dep	1,sc
R7287	T26608	T26609	punct	:,200
R7288	T26609	T26607	prep	200,1
R7289	T26610	T26606	punct	", ",sc
R7290	T26611	T26612	compound	Santa,Cruz
R7291	T26612	T26613	compound	Cruz,Biotechnology
R7292	T26613	T26606	dep	Biotechnology,sc
R7293	T26614	T26606	punct	", ",sc
R7294	T26615	T26606	punct	-,sc
R7295	T26616	T26606	nummod	1237,sc
R7296	T26617	T26606	punct	),sc
R7297	T26618	T26603	punct	", ",goat
R7298	T26619	T26603	conj	rat,goat
R7299	T26620	T26619	amod	anti-TRA98,rat
R7300	T26621	T26622	punct	(,gift
R7301	T26622	T26619	parataxis	gift,rat
R7302	T26623	T26622	dep	1,gift
R7303	T26624	T26625	punct	:,200
R7304	T26625	T26623	prep	200,1
R7305	T26626	T26622	punct	", ",gift
R7306	T26627	T26622	prep	of,gift
R7307	T26628	T26629	compound	H.,Tanaka
R7308	T26629	T26627	pobj	Tanaka,of
R7309	T26630	T26629	cc	and,Tanaka
R7310	T26631	T26632	compound	Y.,Nishimune
R7311	T26632	T26629	conj	Nishimune,Tanaka
R7312	T26633	T26622	punct	),gift
R7313	T26634	T26619	punct	", ",rat
R7314	T26635	T26619	conj	rat,rat
R7315	T26636	T26635	amod	anti-BC7,rat
R7316	T26637	T26638	punct	(,gift
R7317	T26638	T26635	parataxis	gift,rat
R7318	T26639	T26638	dep	1,gift
R7319	T26640	T26641	punct	:,50
R7320	T26641	T26639	prep	50,1
R7321	T26642	T26638	punct	", ",gift
R7322	T26643	T26638	prep	of,gift
R7323	T26644	T26645	compound	H.,Tanaka
R7324	T26645	T26643	pobj	Tanaka,of
R7325	T26646	T26645	cc	and,Tanaka
R7326	T26647	T26648	compound	Y.,Nishimune
R7327	T26648	T26645	conj	Nishimune,Tanaka
R7328	T26649	T26638	punct	),gift
R7329	T26650	T26635	punct	", ",rat
R7330	T26651	T26635	conj	rat,rat
R7331	T26652	T26651	amod	anti-TRA369,rat
R7332	T26653	T26654	punct	(,gift
R7333	T26654	T26651	parataxis	gift,rat
R7334	T26655	T26654	dep	1,gift
R7335	T26656	T26657	punct	:,200
R7336	T26657	T26655	prep	200,1
R7337	T26658	T26654	punct	", ",gift
R7338	T26659	T26654	prep	of,gift
R7339	T26660	T26661	compound	H.,Tanaka
R7340	T26661	T26659	pobj	Tanaka,of
R7341	T26662	T26661	cc	and,Tanaka
R7342	T26663	T26664	compound	Y.,Nishimune
R7343	T26664	T26661	conj	Nishimune,Tanaka
R7344	T26665	T26654	punct	),gift
R7345	T26666	T26651	punct	", ",rat
R7346	T26667	T26651	conj	rabbit,rat
R7347	T26668	T26667	amod	anti-RAD51,rabbit
R7348	T26669	T26670	punct	(,PC130
R7349	T26670	T26667	parataxis	PC130,rabbit
R7350	T26671	T26670	dep	1,PC130
R7351	T26672	T26673	punct	:,600
R7352	T26673	T26671	prep	600,1
R7353	T26674	T26670	dep	Calbiochem,PC130
R7354	T26675	T26674	punct	", ",Calbiochem
R7355	T26676	T26674	npadvmod	http://www.calbiochem.com,Calbiochem
R7356	T26677	T26670	punct	", ",PC130
R7357	T26678	T26670	punct	),PC130
R7358	T26679	T26667	punct	", ",rabbit
R7359	T26680	T26681	nmod	mouse,SUMO
R7360	T26681	T26667	conj	SUMO,rabbit
R7361	T26682	T26681	amod	anti-GMP,SUMO
R7362	T26683	T26681	punct	-,SUMO
R7363	T26684	T26681	nummod	1,SUMO
R7364	T26685	T26681	punct	/,SUMO
R7365	T26686	T26681	punct	-,SUMO
R7366	T26687	T26681	nummod	1,SUMO
R7367	T26688	T26689	punct	(,33
R7368	T26689	T26681	parataxis	33,SUMO
R7369	T26690	T26689	dep	1,33
R7370	T26691	T26692	punct	:,200
R7371	T26692	T26690	prep	200,1
R7372	T26693	T26689	punct	", ",33
R7373	T26694	T26689	dep	Zymed,33
R7374	T26695	T26694	punct	", ",Zymed
R7375	T26696	T26694	npadvmod	http://invitrogen.com,Zymed
R7376	T26697	T26689	punct	", ",33
R7377	T26698	T26699	punct	–,2400
R7378	T26699	T26689	prep	2400,33
R7379	T26700	T26689	punct	),33
R7380	T26701	T26681	punct	", ",SUMO
R7381	T26702	T26703	nmod	rabbit,H2AX
R7382	T26703	T26681	conj	H2AX,SUMO
R7383	T26704	T26703	amod	anti-phospho,H2AX
R7384	T26705	T26703	punct	-,H2AX
R7385	T26706	T26707	punct	(,Ser139
R7386	T26707	T26703	parataxis	Ser139,H2AX
R7387	T26708	T26707	punct	),Ser139
R7388	T26709	T26710	punct	(,01
R7389	T26710	T26703	parataxis	01,H2AX
R7390	T26711	T26710	dep	1,01
R7391	T26712	T26713	punct	:,200
R7392	T26713	T26711	prep	200,1
R7393	T26714	T26710	punct	", ",01
R7394	T26715	T26710	dep	Upstate,01
R7395	T26716	T26715	punct	", ",Upstate
R7396	T26717	T26715	npadvmod	http://www.millipore.com,Upstate
R7397	T26718	T26710	punct	", ",01
R7398	T26719	T26720	punct	–,164
R7399	T26720	T26710	prep	164,01
R7400	T26721	T26710	punct	),01
R7401	T26722	T26703	punct	", ",H2AX
R7402	T26723	T26724	nmod	mouse,H2AX
R7403	T26724	T26703	conj	H2AX,H2AX
R7404	T26725	T26724	amod	anti-phospho,H2AX
R7405	T26726	T26724	punct	-,H2AX
R7406	T26727	T26728	punct	(,05
R7407	T26728	T26724	parataxis	05,H2AX
R7408	T26729	T26728	dep	1,05
R7409	T26730	T26731	punct	:,200
R7410	T26731	T26729	prep	200,1
R7411	T26732	T26728	punct	", ",05
R7412	T26733	T26728	dep	Upstate,05
R7413	T26734	T26728	punct	", ",05
R7414	T26735	T26736	punct	–,636
R7415	T26736	T26728	prep	636,05
R7416	T26737	T26728	punct	),05
R7417	T26738	T26724	punct	", ",H2AX
R7418	T26739	T26724	conj	mouse,H2AX
R7419	T26740	T26739	amod	anti-SYCP3,mouse
R7420	T26741	T26742	punct	(,ab12452
R7421	T26742	T26739	parataxis	ab12452,mouse
R7422	T26743	T26742	dep	1,ab12452
R7423	T26744	T26745	punct	:,200
R7424	T26745	T26743	prep	200,1
R7425	T26746	T26742	punct	", ",ab12452
R7426	T26747	T26742	dep	Abcam,ab12452
R7427	T26748	T26747	punct	", ",Abcam
R7428	T26749	T26747	npadvmod	http://www.abcam.com,Abcam
R7429	T26750	T26742	punct	", ",ab12452
R7430	T26751	T26742	punct	),ab12452
R7431	T26752	T26739	punct	", ",mouse
R7432	T26753	T26739	conj	rabbit,mouse
R7433	T26754	T26753	amod	anti-HP1β,rabbit
R7434	T26755	T26756	punct	(,ab10478
R7435	T26756	T26753	parataxis	ab10478,rabbit
R7436	T26757	T26756	dep	1,ab10478
R7437	T26758	T26759	punct	:,100
R7438	T26759	T26757	prep	100,1
R7439	T26760	T26756	punct	", ",ab10478
R7440	T26761	T26756	dep	Abcam,ab10478
R7441	T26762	T26756	punct	", ",ab10478
R7442	T26763	T26756	punct	),ab10478
R7443	T26764	T26753	punct	", ",rabbit
R7444	T26765	T26766	nmod	rabbit,2meK9
R7445	T26766	T26753	conj	2meK9,rabbit
R7446	T26767	T26766	amod	anti-H3,2meK9
R7447	T26768	T26766	punct	-,2meK9
R7448	T26769	T26770	punct	(,07
R7449	T26770	T26766	parataxis	07,2meK9
R7450	T26771	T26770	dep	1,07
R7451	T26772	T26773	punct	:,100
R7452	T26773	T26771	prep	100,1
R7453	T26774	T26770	punct	", ",07
R7454	T26775	T26770	dep	Upstate,07
R7455	T26776	T26770	punct	", ",07
R7456	T26777	T26778	punct	–,441
R7457	T26778	T26770	prep	441,07
R7458	T26779	T26770	punct	),07
R7459	T26780	T26766	punct	", ",2meK9
R7460	T26781	T26782	nmod	rabbit,3meK9
R7461	T26782	T26766	conj	3meK9,2meK9
R7462	T26783	T26782	amod	anti-H3,3meK9
R7463	T26784	T26782	punct	-,3meK9
R7464	T26785	T26786	punct	(,07
R7465	T26786	T26782	parataxis	07,3meK9
R7466	T26787	T26786	dep	1,07
R7467	T26788	T26789	punct	:,200
R7468	T26789	T26787	prep	200,1
R7469	T26790	T26786	punct	", ",07
R7470	T26791	T26786	dep	Upstate,07
R7471	T26792	T26786	punct	", ",07
R7472	T26793	T26794	punct	–,442
R7473	T26794	T26786	prep	442,07
R7474	T26795	T26786	punct	),07
R7475	T26796	T26782	punct	", ",3meK9
R7476	T26797	T26782	conj	rabbit,3meK9
R7477	T26798	T26797	amod	anti-AR,rabbit
R7478	T26799	T26800	punct	(,N
R7479	T26800	T26797	parataxis	N,rabbit
R7480	T26801	T26800	punct	-,N
R7481	T26802	T26800	nummod	20,N
R7482	T26803	T26800	punct	),N
R7483	T26804	T26805	punct	(,sc
R7484	T26805	T26797	parataxis	sc,rabbit
R7485	T26806	T26805	dep	1,sc
R7486	T26807	T26808	punct	:,200
R7487	T26808	T26806	prep	200,1
R7488	T26809	T26805	punct	", ",sc
R7489	T26810	T26811	compound	Santa,Cruz
R7490	T26811	T26812	compound	Cruz,Biotechnology
R7491	T26812	T26805	dep	Biotechnology,sc
R7492	T26813	T26805	punct	", ",sc
R7493	T26814	T26805	punct	-,sc
R7494	T26815	T26805	nummod	816,sc
R7495	T26816	T26805	punct	),sc
R7496	T26817	T26797	punct	", ",rabbit
R7497	T26818	T26797	cc	and,rabbit
R7498	T26819	T26820	nmod	mouse,1A4
R7499	T26820	T26797	conj	1A4,rabbit
R7500	T26821	T26820	amod	anti-αSMA,1A4
R7501	T26822	T26820	compound	clone,1A4
R7502	T26823	T26824	punct	(,A2547
R7503	T26824	T26820	parataxis	A2547,1A4
R7504	T26825	T26824	dep	1,A2547
R7505	T26826	T26827	punct	:,800
R7506	T26827	T26825	prep	800,1
R7507	T26828	T26824	punct	", ",A2547
R7508	T26829	T26824	dep	Sigma,A2547
R7509	T26830	T26829	punct	", ",Sigma
R7510	T26831	T26829	npadvmod	http://www.sigmaaldrich.com,Sigma
R7511	T26832	T26824	punct	", ",A2547
R7512	T26833	T26824	punct	),A2547
R7513	T26834	T26581	punct	.,were
R7514	T26836	T26837	amod	Secondary,antibodies
R7515	T26837	T26838	nsubj	antibodies,were
R7516	T26839	T26837	acl	used,antibodies
R7517	T26840	T26841	nmod	goat,Alexa
R7518	T26841	T26838	attr	Alexa,were
R7519	T26842	T26841	amod	anti-rabbit,Alexa
R7520	T26843	T26841	nummod	488,Alexa
R7521	T26844	T26841	punct	", ",Alexa
R7522	T26845	T26846	nmod	goat,Alexa
R7523	T26846	T26841	conj	Alexa,Alexa
R7524	T26847	T26846	amod	anti-rabbit,Alexa
R7525	T26848	T26846	nummod	594,Alexa
R7526	T26849	T26846	punct	", ",Alexa
R7527	T26850	T26851	nmod	goat,Alexa
R7528	T26851	T26846	conj	Alexa,Alexa
R7529	T26852	T26851	amod	anti-rat,Alexa
R7530	T26853	T26851	nummod	594,Alexa
R7531	T26854	T26851	punct	", ",Alexa
R7532	T26855	T26851	cc	and,Alexa
R7533	T26856	T26857	nmod	goat,Alexa
R7534	T26857	T26851	conj	Alexa,Alexa
R7535	T26858	T26857	amod	anti-mouse,Alexa
R7536	T26859	T26857	nummod	488,Alexa
R7537	T26860	T26861	punct	(,Probes
R7538	T26861	T26857	parataxis	Probes,Alexa
R7539	T26862	T26861	compound	Molecular,Probes
R7540	T26863	T26861	punct	),Probes
R7541	T26864	T26841	acl	used,Alexa
R7542	T26865	T26864	prep	at,used
R7543	T26866	T26865	pobj	1,at
R7544	T26867	T26868	punct	:,250
R7545	T26868	T26866	prep	250,1
R7546	T26869	T26838	punct	.,were
R7547	T26871	T26872	nmod	Donkey,FITC
R7548	T26872	T26874	nsubjpass	FITC,used
R7549	T26873	T26872	amod	anti-goat,FITC
R7550	T26875	T26876	punct	(,Laboratories
R7551	T26876	T26872	parataxis	Laboratories,FITC
R7552	T26877	T26876	compound	Jackson,Laboratories
R7553	T26878	T26876	compound	ImmunoResearch,Laboratories
R7554	T26879	T26876	punct	", ",Laboratories
R7555	T26880	T26876	npadvmod	http://www.jacksonimmuno.com,Laboratories
R7556	T26881	T26876	punct	),Laboratories
R7557	T26882	T26872	cc	and,FITC
R7558	T26883	T26884	nmod	donkey,Red
R7559	T26884	T26872	conj	Red,FITC
R7560	T26885	T26884	amod	anti-rabbit,Red
R7561	T26886	T26884	compound	Texas,Red
R7562	T26887	T26888	punct	(,Jackson
R7563	T26888	T26884	parataxis	Jackson,Red
R7564	T26889	T26888	punct	),Jackson
R7565	T26890	T26874	auxpass	were,used
R7566	T26891	T26874	prep	at,used
R7567	T26892	T26891	pobj	1,at
R7568	T26893	T26894	punct	:,50
R7569	T26894	T26892	prep	50,1
R7570	T26895	T26874	prep	according,used
R7571	T26896	T26895	prep	to,according
R7572	T26897	T26898	det	the,manufacturer
R7573	T26898	T26899	poss	manufacturer,instructions
R7574	T26899	T26896	pobj	instructions,to
R7575	T26900	T26898	case	's,manufacturer
R7576	T26901	T26874	punct	.,used
R7577	T27179	T27180	amod	Meiotic,chromosome
R7578	T27180	T27181	compound	chromosome,preparations
R7579	T27182	T27181	compound	spread,preparations
R7580	T27183	T27181	cc	and,preparations
R7581	T27184	T27181	conj	FISH,preparations
R7582	T27185	T27184	punct	.,FISH
R7583	T27187	T27188	amod	Meiotic,chromosome
R7584	T27188	T27189	compound	chromosome,preparations
R7585	T27189	T27191	nsubjpass	preparations,made
R7586	T27190	T27189	compound	spread,preparations
R7587	T27192	T27191	auxpass	were,made
R7588	T27193	T27191	prep	from,made
R7589	T27194	T27195	nummod	3,wk
R7590	T27195	T27197	npadvmod	wk,old
R7591	T27196	T27195	punct	-,wk
R7592	T27197	T27199	amod	old,mice
R7593	T27198	T27197	punct	-,old
R7594	T27199	T27193	pobj	mice,from
R7595	T27200	T27191	punct	", ",made
R7596	T27201	T27191	advcl	prepared,made
R7597	T27202	T27203	mark	as,described
R7598	T27203	T27201	advcl	described,prepared
R7599	T27204	T27203	agent	by,described
R7600	T27205	T27204	pobj	Reinholdt,by
R7601	T27206	T27207	advmod	et,al.
R7602	T27207	T27205	advmod	al.,Reinholdt
R7603	T27208	T27209	punct	[,63
R7604	T27209	T27191	parataxis	63,made
R7605	T27210	T27209	punct	],63
R7606	T27211	T27191	punct	.,made
R7607	T27213	T27214	prep	For,prepared
R7608	T27215	T27213	pobj	analysis,For
R7609	T27216	T27215	prep	of,analysis
R7610	T27217	T27216	pobj	PMSC,of
R7611	T27218	T27217	cc	and,PMSC
R7612	T27219	T27220	nmod	Cot,FISH
R7613	T27220	T27217	conj	FISH,PMSC
R7614	T27221	T27219	punct	-,Cot
R7615	T27222	T27219	nummod	1,Cot
R7616	T27223	T27220	compound	RNA,FISH
R7617	T27224	T27214	punct	", ",prepared
R7618	T27225	T27226	amod	meiotic,slides
R7619	T27226	T27214	nsubjpass	slides,prepared
R7620	T27227	T27214	auxpass	were,prepared
R7621	T27228	T27229	mark	as,described
R7622	T27229	T27214	advcl	described,prepared
R7623	T27230	T27229	advmod	previously,described
R7624	T27231	T27232	punct	[,16
R7625	T27232	T27214	parataxis	16,prepared
R7626	T27233	T27232	punct	],16
R7627	T27234	T27214	punct	.,prepared
R7628	T27236	T27237	nsubjpass	Slides,subjected
R7629	T27238	T27236	acl	containing,Slides
R7630	T27239	T27240	compound	chromosome,spreads
R7631	T27240	T27238	dobj	spreads,containing
R7632	T27241	T27240	cc	or,spreads
R7633	T27242	T27243	amod	meiotic,spermatocytes
R7634	T27243	T27240	conj	spermatocytes,spreads
R7635	T27244	T27237	auxpass	were,subjected
R7636	T27245	T27237	prep	to,subjected
R7637	T27246	T27247	amod	immunofluorescent,staining
R7638	T27247	T27245	pobj	staining,to
R7639	T27248	T27247	cc	or,staining
R7640	T27249	T27250	compound	RNA,FISH
R7641	T27250	T27247	conj	FISH,staining
R7642	T27251	T27237	punct	", ",subjected
R7643	T27252	T27253	mark	as,described
R7644	T27253	T27237	advcl	described,subjected
R7645	T27254	T27253	advmod	previously,described
R7646	T27255	T27256	punct	[,63
R7647	T27256	T27237	parataxis	63,subjected
R7648	T27257	T27256	nummod	16,63
R7649	T27258	T27256	punct	",",63
R7650	T27259	T27256	punct	],63
R7651	T27260	T27237	punct	.,subjected
R7652	T27262	T27263	prep	For,carried
R7653	T27264	T27265	amod	combined,FISH
R7654	T27265	T27262	pobj	FISH,For
R7655	T27266	T27265	compound	RNA,FISH
R7656	T27267	T27265	punct	/,FISH
R7657	T27268	T27265	appos	immunostaining,FISH
R7658	T27269	T27263	punct	", ",carried
R7659	T27270	T27263	nsubj	we,carried
R7660	T27271	T27263	prt	out,carried
R7661	T27272	T27273	compound	RNA,FISH
R7662	T27273	T27263	dobj	FISH,carried
R7663	T27274	T27263	advmod	first,carried
R7664	T27275	T27263	punct	", ",carried
R7665	T27276	T27263	advcl	followed,carried
R7666	T27277	T27276	agent	by,followed
R7667	T27278	T27277	pobj	immunofluorescence,by
R7668	T27279	T27263	punct	.,carried
R7669	T27281	T27282	compound	DNA,FISH
R7670	T27282	T27283	nsubjpass	FISH,performed
R7671	T27284	T27283	auxpass	was,performed
R7672	T27285	T27283	advcl	using,performed
R7673	T27286	T27287	compound	chromosome,painting
R7674	T27287	T27285	dobj	painting,using
R7675	T27288	T27289	punct	(,Cambio
R7676	T27289	T27287	parataxis	Cambio,painting
R7677	T27290	T27289	punct	", ",Cambio
R7678	T27291	T27289	npadvmod	http://www.cambio.co.uk,Cambio
R7679	T27292	T27289	punct	),Cambio
R7680	T27293	T27283	punct	.,performed
R7681	T27295	T27296	compound	Z,sections
R7682	T27296	T27298	nsubjpass	sections,captured
R7683	T27297	T27296	punct	-,sections
R7684	T27299	T27298	auxpass	were,captured
R7685	T27300	T27298	prep	by,captured
R7686	T27301	T27302	compound	Zeiss,microscope
R7687	T27302	T27300	pobj	microscope,by
R7688	T27303	T27302	compound	Axioplan,microscope
R7689	T27304	T27305	punct	(,Zeiss
R7690	T27305	T27302	parataxis	Zeiss,microscope
R7691	T27306	T27305	punct	", ",Zeiss
R7692	T27307	T27305	npadvmod	http://www.zeiss.com,Zeiss
R7693	T27308	T27305	punct	),Zeiss
R7694	T27309	T27298	cc	and,captured
R7695	T27310	T27298	conj	processed,captured
R7696	T27311	T27310	prep	by,processed
R7697	T27312	T27311	pobj	Openlab,by
R7698	T27313	T27314	punct	(,Improvision
R7699	T27314	T27312	parataxis	Improvision,Openlab
R7700	T27315	T27314	punct	", ",Improvision
R7701	T27316	T27314	npadvmod	http://www.improvision.com,Improvision
R7702	T27317	T27314	punct	),Improvision
R7703	T27318	T27298	punct	.,captured
R7704	T27760	T27759	prep	of,Expression
R7705	T27761	T27762	compound	Dmrt7,mRNA
R7706	T27762	T27760	pobj	mRNA,of
R7707	T27763	T27762	cc	and,mRNA
R7708	T27764	T27762	conj	Protein,mRNA
R7709	T27766	T27767	punct	(,A
R7710	T27767	T27768	meta	A,analysis
R7711	T27769	T27767	punct	),A
R7712	T27770	T27771	compound	RT,PCR
R7713	T27771	T27768	compound	PCR,analysis
R7714	T27772	T27771	punct	-,PCR
R7715	T27773	T27768	prep	of,analysis
R7716	T27774	T27775	compound	Dmrt7,mRNA
R7717	T27775	T27773	pobj	mRNA,of
R7718	T27776	T27775	prep	from,mRNA
R7719	T27777	T27778	nummod	ten,organs
R7720	T27778	T27776	pobj	organs,from
R7721	T27779	T27778	prep	of,organs
R7722	T27780	T27781	amod	adult,mouse
R7723	T27781	T27779	pobj	mouse,of
R7724	T27782	T27768	punct	.,analysis
R7725	T27784	T27785	nsubjpass	cDNA,amplified
R7726	T27786	T27784	prep	from,cDNA
R7727	T27787	T27788	det	each,organ
R7728	T27788	T27786	pobj	organ,from
R7729	T27789	T27785	auxpass	was,amplified
R7730	T27790	T27785	prep	with,amplified
R7731	T27791	T27790	pobj	primers,with
R7732	T27792	T27791	amod	specific,primers
R7733	T27793	T27792	prep	for,specific
R7734	T27794	T27793	pobj	Dmrt7,for
R7735	T27795	T27796	punct	(,row
R7736	T27796	T27794	parataxis	row,Dmrt7
R7737	T27797	T27796	amod	top,row
R7738	T27798	T27796	punct	),row
R7739	T27799	T27794	cc	and,Dmrt7
R7740	T27800	T27801	compound	β,actin
R7741	T27801	T27794	conj	actin,Dmrt7
R7742	T27802	T27801	punct	-,actin
R7743	T27803	T27804	punct	(,row
R7744	T27804	T27801	parataxis	row,actin
R7745	T27805	T27804	amod	bottom,row
R7746	T27806	T27804	punct	),row
R7747	T27807	T27785	punct	.,amplified
R7748	T27809	T27810	punct	(,B
R7749	T27810	T27811	meta	B,expression
R7750	T27812	T27810	punct	),B
R7751	T27813	T27811	compound	Dmrt7,expression
R7752	T27814	T27811	compound	mRNA,expression
R7753	T27815	T27811	prep	during,expression
R7754	T27816	T27817	det	the,round
R7755	T27817	T27815	pobj	round,during
R7756	T27818	T27817	amod	first,round
R7757	T27819	T27817	prep	of,round
R7758	T27820	T27819	pobj	spermatogenesis,of
R7759	T27821	T27811	punct	.,expression
R7760	T27823	T27824	nsubjpass	cDNAs,amplified
R7761	T27825	T27823	acl	obtained,cDNAs
R7762	T27826	T27825	prep	from,obtained
R7763	T27827	T27826	pobj	testis,from
R7764	T27828	T27825	prep	at,obtained
R7765	T27829	T27830	det	the,days
R7766	T27830	T27828	pobj	days,at
R7767	T27831	T27830	amod	indicated,days
R7768	T27832	T27830	prep	after,days
R7769	T27833	T27832	pobj	birth,after
R7770	T27834	T27824	auxpass	were,amplified
R7771	T27835	T27824	prep	as,amplified
R7772	T27836	T27835	prep	in,as
R7773	T27837	T27836	punct	(,in
R7774	T27838	T27836	pobj	A,in
R7775	T27839	T27824	punct	),amplified
R7776	T27840	T27824	punct	.,amplified
R7777	T27842	T27843	punct	(,C
R7778	T27843	T27844	meta	C,expression
R7779	T27845	T27843	punct	),C
R7780	T27846	T27844	compound	DMRT7,expression
R7781	T27847	T27844	compound	protein,expression
R7782	T27848	T27844	punct	.,expression
R7783	T27851	T27850	prep	of,Immunofluorescence
R7784	T27852	T27853	compound	testis,sections
R7785	T27853	T27851	pobj	sections,of
R7786	T27854	T27853	prep	from,sections
R7787	T27855	T27856	nummod	6,wk
R7788	T27856	T27858	npadvmod	wk,old
R7789	T27857	T27856	punct	-,wk
R7790	T27858	T27860	amod	old,male
R7791	T27859	T27858	punct	-,old
R7792	T27860	T27854	pobj	male,from
R7793	T27861	T27850	acl	stained,Immunofluorescence
R7794	T27862	T27861	prep	with,stained
R7795	T27863	T27862	pobj	antibody,with
R7796	T27864	T27863	prep	to,antibody
R7797	T27865	T27864	pobj	DMRT7,to
R7798	T27866	T27867	punct	(,green
R7799	T27867	T27865	parataxis	green,DMRT7
R7800	T27868	T27867	punct	),green
R7801	T27869	T27865	cc	and,DMRT7
R7802	T27870	T27865	conj	DAPI,DMRT7
R7803	T27871	T27872	punct	(,blue
R7804	T27872	T27870	parataxis	blue,DAPI
R7805	T27873	T27872	punct	),blue
R7806	T27874	T27850	punct	.,Immunofluorescence
R7807	T27876	T27877	punct	(,D
R7808	T27877	T27878	meta	D,localization
R7809	T27879	T27878	punct	),localization
R7810	T27880	T27878	nmod	DMRT7,localization
R7811	T27881	T27878	amod	subcellular,localization
R7812	T27882	T27878	prep	to,localization
R7813	T27883	T27884	compound	XY,body
R7814	T27884	T27882	pobj	body,to
R7815	T27885	T27878	punct	.,localization
R7816	T27887	T27888	compound	Testis,sections
R7817	T27889	T27888	prep	from,sections
R7818	T27890	T27891	nummod	6,wk
R7819	T27891	T27893	npadvmod	wk,old
R7820	T27892	T27891	punct	-,wk
R7821	T27893	T27895	amod	old,male
R7822	T27894	T27893	punct	-,old
R7823	T27895	T27889	pobj	male,from
R7824	T27896	T27888	acl	stained,sections
R7825	T27897	T27896	prep	with,stained
R7826	T27898	T27897	pobj	antibodies,with
R7827	T27899	T27898	prep	to,antibodies
R7828	T27900	T27899	pobj	DMRT7,to
R7829	T27901	T27902	punct	(,red
R7830	T27902	T27900	parataxis	red,DMRT7
R7831	T27903	T27902	punct	),red
R7832	T27904	T27900	cc	and,DMRT7
R7833	T27905	T27900	conj	SUMO,DMRT7
R7834	T27906	T27905	punct	-,SUMO
R7835	T27907	T27905	nummod	1,SUMO
R7836	T27908	T27909	punct	(,green
R7837	T27909	T27905	parataxis	green,SUMO
R7838	T27910	T27909	punct	),green
R7839	T27911	T27888	punct	.,sections
R7840	T27913	T27914	nsubjpass	SUMO,localized
R7841	T27915	T27913	punct	-,SUMO
R7842	T27916	T27913	nummod	1,SUMO
R7843	T27917	T27914	auxpass	is,localized
R7844	T27918	T27914	prep	to,localized
R7845	T27919	T27920	det	the,body
R7846	T27920	T27918	pobj	body,to
R7847	T27921	T27920	compound	XY,body
R7848	T27922	T27914	punct	.,localized
R7849	T27924	T27925	amod	Right-most,panel
R7850	T27925	T27926	nsubj	panel,shows
R7851	T27927	T27926	dobj	merge,shows
R7852	T27928	T27927	prep	of,merge
R7853	T27929	T27930	amod	other,panels
R7854	T27930	T27928	pobj	panels,of
R7855	T27931	T27930	nummod	two,panels
R7856	T27932	T27926	punct	.,shows
R7857	T27934	T27935	nsubj	Inserts,show
R7858	T27936	T27937	amod	higher,magnification
R7859	T27937	T27935	dobj	magnification,show
R7860	T27938	T27937	prep	of,magnification
R7861	T27939	T27940	compound	pachytene,spermatocytes
R7862	T27940	T27938	pobj	spermatocytes,of
R7863	T27941	T27940	prep	with,spermatocytes
R7864	T27942	T27943	compound	XY,bodies
R7865	T27943	T27941	pobj	bodies,with
R7866	T27944	T27935	punct	.,show
R7867	T28480	T28481	amod	Reduced,Size
R7868	T28482	T28481	compound	Testis,Size
R7869	T28483	T28481	cc	and,Size
R7870	T28484	T28485	compound	Germ,Cell
R7871	T28485	T28486	compound	Cell,Apoptosis
R7872	T28486	T28481	conj	Apoptosis,Size
R7873	T28487	T28481	prep	in,Size
R7874	T28488	T28487	pobj	Mice,in
R7875	T28489	T28488	prep	with,Mice
R7876	T28490	T28491	amod	Targeted,Deletion
R7877	T28491	T28489	pobj	Deletion,with
R7878	T28492	T28491	prep	in,Deletion
R7879	T28493	T28492	pobj	Dmrt7,in
R7880	T28495	T28496	punct	(,A
R7881	T28496	T28497	meta	A,Testes
R7882	T28498	T28496	punct	),A
R7883	T28499	T28497	prep	from,Testes
R7884	T28500	T28501	det	a,mouse
R7885	T28501	T28499	pobj	mouse,from
R7886	T28502	T28503	nummod	6,wk
R7887	T28503	T28505	npadvmod	wk,old
R7888	T28504	T28503	punct	-,wk
R7889	T28505	T28501	amod	old,mouse
R7890	T28506	T28505	punct	-,old
R7891	T28507	T28508	amod	wild,type
R7892	T28508	T28501	nmod	type,mouse
R7893	T28509	T28508	punct	-,type
R7894	T28510	T28511	punct	(,+
R7895	T28511	T28501	punct	+,mouse
R7896	T28512	T28511	punct	+,+
R7897	T28513	T28511	punct	/,+
R7898	T28514	T28511	punct	),+
R7899	T28515	T28501	cc	and,mouse
R7900	T28516	T28517	det	a,littermate
R7901	T28517	T28501	conj	littermate,mouse
R7902	T28518	T28517	amod	homozygous,littermate
R7903	T28519	T28520	punct	(,−
R7904	T28520	T28518	punct	−,homozygous
R7905	T28521	T28520	punct	−,−
R7906	T28522	T28520	punct	/,−
R7907	T28523	T28520	punct	),−
R7908	T28524	T28525	compound	Dmrt7,mutant
R7909	T28525	T28517	compound	mutant,littermate
R7910	T28526	T28497	punct	.,Testes
R7911	T28528	T28529	punct	(,B
R7912	T28529	T28530	meta	B,Sections
R7913	T28531	T28529	punct	–,B
R7914	T28532	T28529	dep	D,B
R7915	T28533	T28529	punct	),B
R7916	T28534	T28530	prep	of,Sections
R7917	T28535	T28534	pobj	testes,of
R7918	T28536	T28535	prep	from,testes
R7919	T28537	T28538	nummod	14,d
R7920	T28538	T28540	npadvmod	d,old
R7921	T28539	T28538	punct	-,d
R7922	T28540	T28542	amod	old,mice
R7923	T28541	T28540	punct	-,old
R7924	T28542	T28536	pobj	mice,from
R7925	T28543	T28544	punct	(,B
R7926	T28544	T28540	parataxis	B,old
R7927	T28545	T28544	punct	),B
R7928	T28546	T28540	punct	", ",old
R7929	T28547	T28548	nummod	21,d
R7930	T28548	T28550	npadvmod	d,old
R7931	T28549	T28548	punct	-,d
R7932	T28550	T28540	conj	old,old
R7933	T28551	T28550	punct	-,old
R7934	T28552	T28553	punct	(,C
R7935	T28553	T28550	parataxis	C,old
R7936	T28554	T28553	punct	),C
R7937	T28555	T28550	punct	", ",old
R7938	T28556	T28550	cc	and,old
R7939	T28557	T28558	nummod	42,d
R7940	T28558	T28560	npadvmod	d,old
R7941	T28559	T28558	punct	-,d
R7942	T28560	T28550	conj	old,old
R7943	T28561	T28560	punct	-,old
R7944	T28562	T28563	punct	(,D
R7945	T28563	T28542	parataxis	D,mice
R7946	T28564	T28563	punct	),D
R7947	T28565	T28530	acl	stained,Sections
R7948	T28566	T28565	prep	with,stained
R7949	T28567	T28566	pobj	hematoxylin,with
R7950	T28568	T28567	cc	and,hematoxylin
R7951	T28569	T28567	conj	eosin,hematoxylin
R7952	T28570	T28530	punct	.,Sections
R7953	T28572	T28573	amod	Wild,type
R7954	T28573	T28575	nsubj	type,is
R7955	T28574	T28573	punct	-,type
R7956	T28576	T28575	prep	in,is
R7957	T28577	T28578	amod	left,column
R7958	T28578	T28576	pobj	column,in
R7959	T28579	T28575	cc	and,is
R7960	T28580	T28581	nsubj	mutant,in
R7961	T28581	T28575	conj	in,is
R7962	T28582	T28581	pobj	right,in
R7963	T28583	T28581	punct	.,in
R7964	T28585	T28586	det	No,difference
R7965	T28586	T28588	nsubjpass	difference,observed
R7966	T28587	T28586	amod	significant,difference
R7967	T28589	T28588	auxpass	is,observed
R7968	T28590	T28588	prep	at,observed
R7969	T28591	T28592	nummod	14,d
R7970	T28592	T28590	pobj	d,at
R7971	T28593	T28594	punct	(,B
R7972	T28594	T28588	parataxis	B,observed
R7973	T28595	T28594	punct	),B
R7974	T28596	T28588	punct	", ",observed
R7975	T28597	T28588	cc	but,observed
R7976	T28598	T28599	prep	by,lacking
R7977	T28599	T28588	conj	lacking,observed
R7978	T28600	T28601	nummod	21,d
R7979	T28601	T28598	pobj	d,by
R7980	T28602	T28603	det	some,tubules
R7981	T28603	T28599	nsubj	tubules,lacking
R7982	T28604	T28599	aux	are,lacking
R7983	T28605	T28606	amod	abundant,spermatocytes
R7984	T28606	T28599	dobj	spermatocytes,lacking
R7985	T28607	T28608	punct	(,asterisk
R7986	T28608	T28599	parataxis	asterisk,lacking
R7987	T28609	T28608	dep	C,asterisk
R7988	T28610	T28608	punct	", ",asterisk
R7989	T28611	T28608	punct	),asterisk
R7990	T28612	T28599	cc	or,lacking
R7991	T28613	T28614	nsubj	cells,are
R7992	T28614	T28599	conj	are,lacking
R7993	T28615	T28613	prep	with,cells
R7994	T28616	T28617	amod	typical,morphology
R7995	T28617	T28615	pobj	morphology,with
R7996	T28618	T28617	amod	apoptotic,morphology
R7997	T28619	T28614	acomp	present,are
R7998	T28620	T28621	punct	(,C
R7999	T28621	T28614	parataxis	C,are
R8000	T28622	T28623	amod	open,arrowhead
R8001	T28623	T28621	dep	arrowhead,C
R8002	T28624	T28621	punct	", ",C
R8003	T28625	T28621	cc	and,C
R8004	T28626	T28621	conj	D,C
R8005	T28627	T28621	punct	),C
R8006	T28628	T28599	punct	.,lacking
R8007	T28630	T28631	compound	Mutant,tubules
R8008	T28631	T28632	nsubj	tubules,contain
R8009	T28633	T28634	amod	multinucleate,cells
R8010	T28634	T28632	dobj	cells,contain
R8011	T28635	T28636	punct	(,D
R8012	T28636	T28632	parataxis	D,contain
R8013	T28637	T28638	amod	closed,arrowhead
R8014	T28638	T28636	dep	arrowhead,D
R8015	T28639	T28636	punct	", ",D
R8016	T28640	T28636	punct	),D
R8017	T28641	T28632	punct	.,contain
R8018	T28643	T28644	punct	(,E
R8019	T28644	T28645	meta	E,labeling
R8020	T28646	T28644	cc	and,E
R8021	T28647	T28644	conj	F,E
R8022	T28648	T28647	punct	),F
R8023	T28649	T28645	compound	TUNEL,labeling
R8024	T28650	T28645	prep	of,labeling
R8025	T28651	T28652	npadvmod	Dmrt7,deficient
R8026	T28652	T28654	amod	deficient,testes
R8027	T28653	T28652	punct	-,deficient
R8028	T28654	T28650	pobj	testes,of
R8029	T28655	T28654	compound	mouse,testes
R8030	T28656	T28645	punct	.,labeling
R8031	T28658	T28659	nsubjpass	Testes,analyzed
R8032	T28660	T28658	prep	from,Testes
R8033	T28661	T28662	amod	wild,type
R8034	T28662	T28664	nmod	type,littermates
R8035	T28663	T28662	punct	-,type
R8036	T28664	T28660	pobj	littermates,from
R8037	T28665	T28662	cc	and,type
R8038	T28666	T28662	conj	homozygous,type
R8039	T28667	T28664	compound	mutant,littermates
R8040	T28668	T28659	auxpass	were,analyzed
R8041	T28669	T28659	prep	by,analyzed
R8042	T28670	T28671	compound	TUNEL,labeling
R8043	T28671	T28669	pobj	labeling,by
R8044	T28672	T28673	aux	to,detect
R8045	T28673	T28659	advcl	detect,analyzed
R8046	T28674	T28675	amod	apoptotic,cells
R8047	T28675	T28673	dobj	cells,detect
R8048	T28676	T28659	punct	.,analyzed
R8049	T28678	T28679	compound	Testis,sections
R8050	T28680	T28679	prep	from,sections
R8051	T28681	T28682	nummod	21,d
R8052	T28682	T28684	npadvmod	d,old
R8053	T28683	T28682	punct	-,d
R8054	T28684	T28686	amod	old,mice
R8055	T28685	T28684	punct	-,old
R8056	T28686	T28680	pobj	mice,from
R8057	T28687	T28688	punct	(,E
R8058	T28688	T28684	parataxis	E,old
R8059	T28689	T28688	punct	),E
R8060	T28690	T28684	cc	and,old
R8061	T28691	T28692	nummod	6,wk
R8062	T28692	T28694	npadvmod	wk,old
R8063	T28693	T28692	punct	-,wk
R8064	T28694	T28684	conj	old,old
R8065	T28695	T28694	punct	-,old
R8066	T28696	T28697	punct	(,F
R8067	T28697	T28686	parataxis	F,mice
R8068	T28698	T28697	punct	),F
R8069	T28699	T28679	punct	.,sections
R8070	T28701	T28702	amod	Apoptotic,cells
R8071	T28702	T28703	nsubj	cells,are
R8072	T28704	T28705	punct	(,brown
R8073	T28705	T28702	parataxis	brown,cells
R8074	T28706	T28705	punct	),brown
R8075	T28707	T28708	advmod	much,more
R8076	T28708	T28709	advmod	more,abundant
R8077	T28709	T28703	acomp	abundant,are
R8078	T28710	T28703	prep	in,are
R8079	T28711	T28712	amod	seminiferous,tubules
R8080	T28712	T28710	pobj	tubules,in
R8081	T28713	T28712	prep	of,tubules
R8082	T28714	T28715	amod	homozygous,mice
R8083	T28715	T28713	pobj	mice,of
R8084	T28716	T28717	compound	Dmrt7,mutant
R8085	T28717	T28715	compound	mutant,mice
R8086	T28718	T28703	advcl	relative,are
R8087	T28719	T28718	prep	to,relative
R8088	T28720	T28721	amod	wild,type
R8089	T28721	T28719	pobj	type,to
R8090	T28722	T28721	punct	-,type
R8091	T28723	T28703	punct	.,are
R8092	T28725	T28726	nsubj	Bars,represent
R8093	T28727	T28725	prep	in,Bars
R8094	T28728	T28729	punct	(,B
R8095	T28729	T28727	pobj	B,in
R8096	T28730	T28731	punct	–,F
R8097	T28731	T28729	prep	F,B
R8098	T28732	T28726	punct	),represent
R8099	T28733	T28734	nummod	100,μm
R8100	T28734	T28726	dobj	μm,represent
R8101	T28735	T28726	punct	.,represent
R8102	T28985	T28986	nmod	Prophase,Arrest
R8103	T28987	T28985	nummod	I,Prophase
R8104	T28988	T28986	prep	of,Arrest
R8105	T28989	T28990	compound	Dmrt7,Mutant
R8106	T28990	T28991	compound	Mutant,Cells
R8107	T28991	T28988	pobj	Cells,of
R8108	T28992	T28991	compound	Germ,Cells
R8109	T28994	T28995	compound	Testis,sections
R8110	T28996	T28995	prep	from,sections
R8111	T28997	T28998	nummod	6,wk
R8112	T28998	T29000	npadvmod	wk,old
R8113	T28999	T28998	punct	-,wk
R8114	T29000	T29002	amod	old,littermates
R8115	T29001	T29000	punct	-,old
R8116	T29002	T28996	pobj	littermates,from
R8117	T29003	T29004	amod	wild,type
R8118	T29004	T29002	nmod	type,littermates
R8119	T29005	T29004	punct	-,type
R8120	T29006	T29007	punct	(,+
R8121	T29007	T29004	punct	+,type
R8122	T29008	T29007	punct	+,+
R8123	T29009	T29007	punct	/,+
R8124	T29010	T29007	punct	),+
R8125	T29011	T29004	cc	and,type
R8126	T29012	T29013	compound	Dmrt7,mutant
R8127	T29013	T29004	conj	mutant,type
R8128	T29014	T29015	punct	(,−
R8129	T29015	T29013	punct	−,mutant
R8130	T29016	T29015	punct	−,−
R8131	T29017	T29015	punct	/,−
R8132	T29018	T29015	punct	),−
R8133	T29019	T28995	acl	stained,sections
R8134	T29020	T29019	prep	with,stained
R8135	T29021	T29022	npadvmod	stage,specific
R8136	T29022	T29024	amod	specific,antibodies
R8137	T29023	T29022	punct	-,specific
R8138	T29024	T29020	pobj	antibodies,with
R8139	T29025	T29024	amod	specific,antibodies
R8140	T29026	T29025	prep	to,specific
R8141	T29027	T29028	amod	spermatogenic,cells
R8142	T29028	T29026	pobj	cells,to
R8143	T29029	T28995	punct	.,sections
R8144	T29031	T29032	punct	(,A
R8145	T29032	T29033	meta	A,stains
R8146	T29034	T29032	punct	),A
R8147	T29035	T29036	compound	TRA98,antibody
R8148	T29036	T29033	nsubj	antibody,stains
R8149	T29037	T29033	advmod	strongly,stains
R8150	T29038	T29033	dobj	spermatogonia,stains
R8151	T29039	T29038	punct	", ",spermatogonia
R8152	T29040	T29041	dep	which,are
R8153	T29041	T29038	relcl	are,spermatogonia
R8154	T29042	T29041	acomp	present,are
R8155	T29043	T29041	prep	in,are
R8156	T29044	T29045	amod	wild,type
R8157	T29045	T29043	pobj	type,in
R8158	T29046	T29045	punct	-,type
R8159	T29047	T29045	cc	and,type
R8160	T29048	T29045	conj	mutant,type
R8161	T29049	T29033	punct	.,stains
R8162	T29051	T29052	punct	(,B
R8163	T29052	T29053	meta	B,stains
R8164	T29054	T29052	punct	),B
R8165	T29055	T29056	compound	BC7,antibody
R8166	T29056	T29053	nsubj	antibody,stains
R8167	T29057	T29053	dobj	spermatocytes,stains
R8168	T29058	T29057	punct	", ",spermatocytes
R8169	T29059	T29060	dep	which,are
R8170	T29060	T29057	relcl	are,spermatocytes
R8171	T29061	T29060	acomp	present,are
R8172	T29062	T29060	prep	in,are
R8173	T29063	T29064	amod	wild,type
R8174	T29064	T29062	pobj	type,in
R8175	T29065	T29064	punct	-,type
R8176	T29066	T29064	cc	and,type
R8177	T29067	T29064	conj	mutant,type
R8178	T29068	T29053	punct	.,stains
R8179	T29070	T29071	punct	(,C
R8180	T29071	T29072	meta	C,stains
R8181	T29073	T29071	punct	),C
R8182	T29074	T29075	compound	TRA369,antibody
R8183	T29075	T29072	nsubj	antibody,stains
R8184	T29076	T29077	nmod	pachytene,cells
R8185	T29077	T29072	dobj	cells,stains
R8186	T29078	T29076	cc	and,pachytene
R8187	T29079	T29076	conj	later,pachytene
R8188	T29080	T29077	compound	germ,cells
R8189	T29081	T29077	punct	", ",cells
R8190	T29082	T29083	dep	which,are
R8191	T29083	T29077	relcl	are,cells
R8192	T29084	T29085	advmod	severely,deficient
R8193	T29085	T29083	acomp	deficient,are
R8194	T29086	T29083	prep	in,are
R8195	T29087	T29088	det	the,testis
R8196	T29088	T29086	pobj	testis,in
R8197	T29089	T29088	compound	mutant,testis
R8198	T29090	T29072	punct	.,stains
R8201	T29241	T29240	prep	of,Profile
R8202	T29242	T29243	amod	Meiotic,Arrest
R8203	T29243	T29241	pobj	Arrest,of
R8204	T29244	T29240	prep	in,Profile
R8205	T29245	T29246	compound	Dmrt7,Mutant
R8206	T29246	T29247	compound	Mutant,Testis
R8207	T29247	T29244	pobj	Testis,in
R8208	T29250	T29249	prep	of,Graph
R8209	T29251	T29250	pobj	distribution,of
R8210	T29252	T29251	prep	of,distribution
R8211	T29253	T29254	amod	meiotic,stages
R8212	T29254	T29252	pobj	stages,of
R8213	T29255	T29254	prep	of,stages
R8214	T29256	T29257	compound	germ,cells
R8215	T29257	T29255	pobj	cells,of
R8216	T29258	T29251	prep	from,distribution
R8217	T29259	T29260	amod	heterozygous,mutant
R8218	T29260	T29268	nmod	mutant,testes
R8219	T29261	T29262	punct	(,"1,970"
R8220	T29262	T29259	parataxis	"1,970",heterozygous
R8221	T29263	T29262	nsubj	n,"1,970"
R8222	T29264	T29262	punct	=,"1,970"
R8223	T29265	T29262	punct	),"1,970"
R8224	T29266	T29259	cc	and,heterozygous
R8225	T29267	T29259	conj	homozygous,heterozygous
R8226	T29268	T29258	pobj	testes,from
R8227	T29269	T29270	punct	(,"2,084"
R8228	T29270	T29260	parataxis	"2,084",mutant
R8229	T29271	T29270	nsubj	n,"2,084"
R8230	T29272	T29270	punct	=,"2,084"
R8231	T29273	T29270	punct	),"2,084"
R8232	T29274	T29268	compound	P26,testes
R8233	T29275	T29249	punct	", ",Graph
R8234	T29276	T29249	acl	spread,Graph
R8235	T29277	T29276	cc	and,spread
R8236	T29278	T29276	conj	stained,spread
R8237	T29279	T29278	prep	for,stained
R8238	T29280	T29281	det	the,SYCP3
R8239	T29281	T29279	pobj	SYCP3,for
R8240	T29282	T29281	amod	synaptonemal,SYCP3
R8241	T29283	T29284	compound	complex,protein
R8242	T29284	T29281	compound	protein,SYCP3
R8243	T29285	T29286	aux	to,permit
R8244	T29286	T29278	advcl	permit,stained
R8245	T29287	T29288	amod	precise,staging
R8246	T29288	T29286	dobj	staging,permit
R8247	T29289	T29288	punct	", ",staging
R8248	T29290	T29291	dep	which,performed
R8249	T29291	T29288	relcl	performed,staging
R8250	T29292	T29291	auxpass	was,performed
R8251	T29293	T29294	mark	as,described
R8252	T29294	T29291	advcl	described,performed
R8253	T29295	T29296	punct	[,65
R8254	T29296	T29278	parataxis	65,stained
R8255	T29297	T29296	nummod	64,65
R8256	T29298	T29296	punct	",",65
R8257	T29299	T29296	punct	],65
R8258	T29300	T29249	punct	.,Graph
R8259	T29623	T29624	amod	Normal,Synapsis
R8260	T29625	T29624	cc	and,Synapsis
R8261	T29626	T29624	conj	Recombination,Synapsis
R8262	T29627	T29624	prep	in,Synapsis
R8263	T29628	T29629	compound	Dmrt7,Mutant
R8264	T29629	T29630	compound	Mutant,Cells
R8265	T29630	T29627	pobj	Cells,in
R8266	T29631	T29630	compound	Germ,Cells
R8267	T29633	T29634	punct	(,A
R8268	T29634	T29635	meta	A,spread
R8269	T29636	T29634	punct	),A
R8270	T29637	T29638	amod	Testicular,cells
R8271	T29638	T29635	nsubjpass	cells,spread
R8272	T29639	T29638	prep	from,cells
R8273	T29640	T29641	nmod	Dmrt7,mutant
R8274	T29641	T29655	compound	mutant,mice
R8275	T29642	T29641	amod	heterozygous,mutant
R8276	T29643	T29644	punct	(,−
R8277	T29644	T29642	punct	−,heterozygous
R8278	T29645	T29644	punct	+,−
R8279	T29646	T29644	punct	/,−
R8280	T29647	T29644	punct	),−
R8281	T29648	T29642	cc	or,heterozygous
R8282	T29649	T29642	conj	homozygous,heterozygous
R8283	T29650	T29651	punct	(,−
R8284	T29651	T29649	punct	−,homozygous
R8285	T29652	T29651	punct	−,−
R8286	T29653	T29651	punct	/,−
R8287	T29654	T29651	punct	),−
R8288	T29655	T29639	pobj	mice,from
R8289	T29656	T29635	auxpass	were,spread
R8290	T29657	T29635	cc	and,spread
R8291	T29658	T29635	conj	stained,spread
R8292	T29659	T29658	prep	with,stained
R8293	T29660	T29659	pobj	antibody,with
R8294	T29661	T29660	prep	to,antibody
R8295	T29662	T29661	pobj	SYCP3,to
R8296	T29663	T29664	punct	(,red
R8297	T29664	T29658	parataxis	red,stained
R8298	T29665	T29664	punct	),red
R8299	T29666	T29635	punct	.,spread
R8300	T29668	T29669	det	The,stages
R8301	T29669	T29671	nsubjpass	stages,indicated
R8302	T29670	T29669	amod	developmental,stages
R8303	T29672	T29669	prep	of,stages
R8304	T29673	T29674	amod	meiotic,prophase
R8305	T29674	T29672	pobj	prophase,of
R8306	T29675	T29669	prep	based,stages
R8307	T29676	T29675	prep	on,based
R8308	T29677	T29678	compound	SYCP3,organization
R8309	T29678	T29676	pobj	organization,on
R8310	T29679	T29671	auxpass	are,indicated
R8311	T29680	T29671	prep	in,indicated
R8312	T29681	T29682	det	each,panel
R8313	T29682	T29680	pobj	panel,in
R8314	T29683	T29671	punct	.,indicated
R8315	T29685	T29686	prep	By,synapsed
R8316	T29687	T29685	pobj	pachynema,By
R8317	T29688	T29686	punct	", ",synapsed
R8318	T29689	T29690	det	all,autosomes
R8319	T29690	T29686	nsubjpass	autosomes,synapsed
R8320	T29691	T29686	auxpass	are,synapsed
R8321	T29692	T29686	advmod	fully,synapsed
R8322	T29693	T29686	punct	", ",synapsed
R8323	T29694	T29686	cc	and,synapsed
R8324	T29695	T29696	det	the,XY
R8325	T29696	T29697	nsubjpass	XY,synapsed
R8326	T29697	T29686	conj	synapsed,synapsed
R8327	T29698	T29696	amod	bivalent,XY
R8328	T29699	T29697	auxpass	is,synapsed
R8329	T29700	T29701	advmod	only,at
R8330	T29701	T29697	prep	at,synapsed
R8331	T29702	T29703	det	the,region
R8332	T29703	T29701	pobj	region,at
R8333	T29704	T29703	amod	pseudoautosomal,region
R8334	T29705	T29697	prep	in,synapsed
R8335	T29706	T29707	preconj	both,type
R8336	T29707	T29710	nmod	type,cells
R8337	T29708	T29707	amod	wild,type
R8338	T29709	T29707	punct	-,type
R8339	T29710	T29705	pobj	cells,in
R8340	T29711	T29707	cc	and,type
R8341	T29712	T29707	conj	mutant,type
R8342	T29713	T29686	punct	.,synapsed
R8343	T29715	T29716	punct	(,B
R8344	T29716	T29717	meta	B,cells
R8345	T29718	T29716	punct	),B
R8346	T29719	T29717	amod	Testicular,cells
R8347	T29720	T29717	prep	in,cells
R8348	T29721	T29720	pobj	zygonema,in
R8349	T29722	T29721	cc	and,zygonema
R8350	T29723	T29721	conj	pachynema,zygonema
R8351	T29724	T29717	acl	spread,cells
R8352	T29725	T29724	cc	and,spread
R8353	T29726	T29724	conj	stained,spread
R8354	T29727	T29726	prep	with,stained
R8355	T29728	T29727	pobj	antibodies,with
R8356	T29729	T29728	prep	to,antibodies
R8357	T29730	T29729	pobj	RAD51,to
R8358	T29731	T29732	punct	(,green
R8359	T29732	T29730	parataxis	green,RAD51
R8360	T29733	T29732	punct	),green
R8361	T29734	T29730	cc	and,RAD51
R8362	T29735	T29730	conj	SYCP3,RAD51
R8363	T29736	T29737	punct	(,red
R8364	T29737	T29735	parataxis	red,SYCP3
R8365	T29738	T29737	punct	),red
R8366	T29739	T29717	punct	.,cells
R8367	T29741	T29742	nsubj	Size,are
R8368	T29743	T29741	cc	and,Size
R8369	T29744	T29741	conj	distribution,Size
R8370	T29745	T29741	prep	of,Size
R8371	T29746	T29747	compound	RAD51,foci
R8372	T29747	T29745	pobj	foci,of
R8373	T29748	T29742	acomp	similar,are
R8374	T29749	T29742	prep	between,are
R8375	T29750	T29751	amod	wild,type
R8376	T29751	T29753	nmod	type,spermatocytes
R8377	T29752	T29751	punct	-,type
R8378	T29753	T29749	pobj	spermatocytes,between
R8379	T29754	T29751	cc	and,type
R8380	T29755	T29751	conj	mutant,type
R8381	T29756	T29742	punct	.,are
R8382	T30296	T30297	amod	Abnormal,Organization
R8383	T30298	T30299	compound	Sertoli,Cell
R8384	T30299	T30297	compound	Cell,Organization
R8385	T30300	T30297	prep	in,Organization
R8386	T30301	T30302	compound	Dmrt7,Mutant
R8387	T30302	T30303	compound	Mutant,Testes
R8388	T30303	T30300	pobj	Testes,in
R8389	T30305	T30306	punct	(,A
R8390	T30306	T30307	meta	A,sectioned
R8391	T30308	T30306	punct	),A
R8392	T30309	T30307	nsubjpass	Testes,sectioned
R8393	T30310	T30309	prep	from,Testes
R8394	T30311	T30312	nmod	P14,mice
R8395	T30312	T30310	pobj	mice,from
R8396	T30313	T30314	amod	wild,type
R8397	T30314	T30312	nmod	type,mice
R8398	T30315	T30314	punct	-,type
R8399	T30316	T30314	cc	and,type
R8400	T30317	T30314	conj	Dmrt7,type
R8401	T30318	T30312	compound	mutant,mice
R8402	T30319	T30307	auxpass	were,sectioned
R8403	T30320	T30307	cc	and,sectioned
R8404	T30321	T30307	conj	stained,sectioned
R8405	T30322	T30321	prep	with,stained
R8406	T30323	T30322	pobj	antibody,with
R8407	T30324	T30323	prep	to,antibody
R8408	T30325	T30324	pobj	GATA4,to
R8409	T30326	T30307	punct	.,sectioned
R8410	T30328	T30329	punct	(,B
R8411	T30329	T30330	meta	B,sections
R8412	T30331	T30329	punct	),B
R8413	T30332	T30330	compound	P14,sections
R8414	T30333	T30330	compound	testis,sections
R8415	T30334	T30330	acl	stained,sections
R8416	T30335	T30334	prep	with,stained
R8417	T30336	T30335	pobj	antibody,with
R8418	T30337	T30336	prep	to,antibody
R8419	T30338	T30337	pobj	GATA1,to
R8420	T30339	T30330	punct	.,sections
R8421	T30341	T30342	prep	At,are
R8422	T30343	T30341	pobj	P14,At
R8423	T30344	T30342	punct	", ",are
R8424	T30345	T30346	nmod	GATA4,levels
R8425	T30346	T30342	nsubj	levels,are
R8426	T30347	T30345	cc	and,GATA4
R8427	T30348	T30345	conj	GATA1,GATA4
R8428	T30349	T30342	acomp	similar,are
R8429	T30350	T30342	prep	in,are
R8430	T30351	T30352	amod	wild,type
R8431	T30352	T30354	nmod	type,cell
R8432	T30353	T30352	punct	-,type
R8433	T30354	T30350	pobj	cell,in
R8434	T30355	T30352	cc	and,type
R8435	T30356	T30352	conj	mutant,type
R8436	T30357	T30354	compound	Sertoli,cell
R8437	T30358	T30342	punct	.,are
R8438	T30360	T30361	punct	(,C
R8439	T30361	T30362	meta	C,sections
R8440	T30363	T30361	punct	),C
R8441	T30364	T30365	amod	Wild,type
R8442	T30365	T30362	nmod	type,sections
R8443	T30366	T30365	punct	-,type
R8444	T30367	T30365	cc	and,type
R8445	T30368	T30365	conj	mutant,type
R8446	T30369	T30362	compound	testis,sections
R8447	T30370	T30371	advmod	double,stained
R8448	T30371	T30362	acl	stained,sections
R8449	T30372	T30371	punct	-,stained
R8450	T30373	T30371	prep	with,stained
R8451	T30374	T30373	pobj	antibody,with
R8452	T30375	T30374	prep	to,antibody
R8453	T30376	T30375	pobj	GATA1,to
R8454	T30377	T30378	punct	(,red
R8455	T30378	T30376	parataxis	red,GATA1
R8456	T30379	T30378	punct	),red
R8457	T30380	T30376	cc	and,GATA1
R8458	T30381	T30376	conj	DAPI,GATA1
R8459	T30382	T30383	punct	(,blue
R8460	T30383	T30381	parataxis	blue,DAPI
R8461	T30384	T30383	punct	),blue
R8462	T30385	T30362	punct	.,sections
R8463	T30387	T30388	amod	Most,nuclei
R8464	T30388	T30391	nsubj	nuclei,were
R8465	T30389	T30390	compound	Sertoli,cell
R8466	T30390	T30388	compound	cell,nuclei
R8467	T30392	T30391	acomp	adjacent,were
R8468	T30393	T30392	prep	to,adjacent
R8469	T30394	T30395	det	the,membrane
R8470	T30395	T30393	pobj	membrane,to
R8471	T30396	T30395	amod	basal,membrane
R8472	T30397	T30391	prep	in,were
R8473	T30398	T30399	amod	wild,type
R8474	T30399	T30397	pobj	type,in
R8475	T30400	T30399	punct	-,type
R8476	T30401	T30391	punct	", ",were
R8477	T30402	T30391	cc	but,were
R8478	T30403	T30404	compound	mutant,cells
R8479	T30404	T30406	nsubjpass	cells,displaced
R8480	T30405	T30404	compound	Sertoli,cells
R8481	T30406	T30391	conj	displaced,were
R8482	T30407	T30406	auxpass	were,displaced
R8483	T30408	T30406	prep	in,displaced
R8484	T30409	T30410	det	some,tubules
R8485	T30410	T30408	pobj	tubules,in
R8486	T30411	T30412	punct	(,arrowhead
R8487	T30412	T30406	parataxis	arrowhead,displaced
R8488	T30413	T30412	punct	),arrowhead
R8489	T30414	T30406	punct	.,displaced
R8490	T30416	T30417	amod	White,line
R8491	T30417	T30419	nsubj	line,indicates
R8492	T30418	T30417	amod	dotted,line
R8493	T30420	T30419	dobj	position,indicates
R8494	T30421	T30420	prep	of,position
R8495	T30422	T30423	amod	basal,membranes
R8496	T30423	T30421	pobj	membranes,of
R8497	T30424	T30419	punct	.,indicates
R8498	T30426	T30427	punct	(,D
R8499	T30427	T30428	meta	D,sections
R8500	T30429	T30427	punct	),D
R8501	T30430	T30428	compound	Testis,sections
R8502	T30431	T30428	prep	from,sections
R8503	T30432	T30433	nummod	10,wk
R8504	T30433	T30435	npadvmod	wk,old
R8505	T30434	T30433	punct	-,wk
R8506	T30435	T30437	amod	old,mice
R8507	T30436	T30435	punct	-,old
R8508	T30437	T30431	pobj	mice,from
R8509	T30438	T30439	amod	wild,type
R8510	T30439	T30437	nmod	type,mice
R8511	T30440	T30439	punct	-,type
R8512	T30441	T30439	cc	and,type
R8513	T30442	T30443	compound	Sertoli,cell
R8514	T30443	T30444	npadvmod	cell,specific
R8515	T30444	T30446	amod	specific,mutant
R8516	T30445	T30444	punct	-,specific
R8517	T30446	T30439	conj	mutant,type
R8518	T30447	T30446	compound	Dmrt7,mutant
R8519	T30448	T30446	punct	(,mutant
R8520	T30449	T30450	compound	SC,Dmrt7KO
R8521	T30450	T30446	appos	Dmrt7KO,mutant
R8522	T30451	T30450	punct	-,Dmrt7KO
R8523	T30452	T30437	punct	),mice
R8524	T30453	T30428	acl	stained,sections
R8525	T30454	T30453	prep	with,stained
R8526	T30455	T30454	pobj	hematoxylin,with
R8527	T30456	T30455	cc	and,hematoxylin
R8528	T30457	T30455	conj	eosin,hematoxylin
R8529	T30458	T30428	punct	.,sections
R8530	T30460	T30461	nsubj	Spermatogenesis,are
R8531	T30462	T30460	cc	and,Spermatogenesis
R8532	T30463	T30460	conj	spermiogenesis,Spermatogenesis
R8533	T30464	T30461	acomp	normal,are
R8534	T30465	T30461	prep	in,are
R8535	T30466	T30467	compound	SC,Dmrt7KO
R8536	T30467	T30469	compound	Dmrt7KO,testis
R8537	T30468	T30467	punct	-,Dmrt7KO
R8538	T30469	T30465	pobj	testis,in
R8539	T30470	T30461	punct	.,are
R8540	T30472	T30473	punct	(,E
R8541	T30473	T30474	meta	E,sections
R8542	T30475	T30473	punct	),E
R8543	T30476	T30474	compound	Testis,sections
R8544	T30477	T30474	prep	from,sections
R8545	T30478	T30479	nummod	10,wk
R8546	T30479	T30481	npadvmod	wk,old
R8547	T30480	T30479	punct	-,wk
R8548	T30481	T30483	amod	old,mice
R8549	T30482	T30481	punct	-,old
R8550	T30483	T30477	pobj	mice,from
R8551	T30484	T30485	amod	wild,type
R8552	T30485	T30483	nmod	type,mice
R8553	T30486	T30485	punct	-,type
R8554	T30487	T30485	cc	and,type
R8555	T30488	T30489	compound	SC,Dmrt7KO
R8556	T30489	T30485	conj	Dmrt7KO,type
R8557	T30490	T30489	punct	-,Dmrt7KO
R8558	T30491	T30474	acl	stained,sections
R8559	T30492	T30491	prep	with,stained
R8560	T30493	T30492	pobj	antibodies,with
R8561	T30494	T30493	prep	to,antibodies
R8562	T30495	T30494	pobj	GATA1,to
R8563	T30496	T30497	punct	(,red
R8564	T30497	T30493	parataxis	red,antibodies
R8565	T30498	T30497	punct	),red
R8566	T30499	T30493	cc	and,antibodies
R8567	T30500	T30501	amod	smooth,actin
R8568	T30501	T30493	conj	actin,antibodies
R8569	T30502	T30501	compound	muscle,actin
R8570	T30503	T30504	punct	(,outline
R8571	T30504	T30501	parataxis	outline,actin
R8572	T30505	T30504	aux	to,outline
R8573	T30506	T30507	amod	seminiferous,tubules
R8574	T30507	T30504	dobj	tubules,outline
R8575	T30508	T30504	punct	;,outline
R8576	T30509	T30504	amod	green,outline
R8577	T30510	T30504	punct	),outline
R8578	T30511	T30474	punct	.,sections
R8579	T30513	T30514	compound	Sertoli,cell
R8580	T30514	T30515	compound	cell,nuclei
R8581	T30515	T30516	nsubjpass	nuclei,positioned
R8582	T30517	T30516	auxpass	are,positioned
R8583	T30518	T30516	advmod	normally,positioned
R8584	T30519	T30516	prep	near,positioned
R8585	T30520	T30521	det	the,membrane
R8586	T30521	T30519	pobj	membrane,near
R8587	T30522	T30521	amod	basal,membrane
R8588	T30523	T30516	prep	in,positioned
R8589	T30524	T30525	compound	SC,Dmrt7KO
R8590	T30525	T30527	compound	Dmrt7KO,mice
R8591	T30526	T30525	punct	-,Dmrt7KO
R8592	T30527	T30523	pobj	mice,in
R8593	T30528	T30516	punct	.,positioned
R8594	T30803	T30804	compound	XY,Body
R8595	T30804	T30805	nsubj	Body,Forms
R8596	T30806	T30805	advmod	Normally,Forms
R8597	T30807	T30805	prep	during,Forms
R8598	T30808	T30807	pobj	Pachynema,during
R8599	T30809	T30805	prep	in,Forms
R8600	T30810	T30811	compound	Dmrt7,Mutant
R8601	T30811	T30812	compound	Mutant,Mice
R8602	T30812	T30809	pobj	Mice,in
R8603	T30814	T30815	punct	(,cells
R8604	T30816	T30815	meta	A,cells
R8605	T30817	T30815	punct	),cells
R8606	T30818	T30815	amod	Testicular,cells
R8607	T30819	T30815	acl	spread,cells
R8608	T30820	T30819	cc	and,spread
R8609	T30821	T30819	conj	stained,spread
R8610	T30822	T30821	prep	with,stained
R8611	T30823	T30822	pobj	antibodies,with
R8612	T30824	T30823	prep	to,antibodies
R8613	T30825	T30824	pobj	γH2AX,to
R8614	T30826	T30827	punct	(,red
R8615	T30827	T30825	parataxis	red,γH2AX
R8616	T30828	T30827	punct	),red
R8617	T30829	T30825	cc	and,γH2AX
R8618	T30830	T30825	conj	SYCP3,γH2AX
R8619	T30831	T30832	punct	(,green
R8620	T30832	T30830	parataxis	green,SYCP3
R8621	T30833	T30832	punct	),green
R8622	T30834	T30815	punct	.,cells
R8623	T30836	T30837	prep	In,concentrated
R8624	T30838	T30839	compound	pachytene,cells
R8625	T30839	T30836	pobj	cells,In
R8626	T30840	T30837	punct	", ",concentrated
R8627	T30841	T30837	nsubjpass	γH2AX,concentrated
R8628	T30842	T30837	auxpass	is,concentrated
R8629	T30843	T30837	prep	in,concentrated
R8630	T30844	T30845	det	the,body
R8631	T30845	T30843	pobj	body,in
R8632	T30846	T30845	compound	XY,body
R8633	T30847	T30848	preconj	both,in
R8634	T30848	T30837	prep	in,concentrated
R8635	T30849	T30850	amod	wild,type
R8636	T30850	T30848	pobj	type,in
R8637	T30851	T30850	punct	-,type
R8638	T30852	T30850	cc	and,type
R8639	T30853	T30854	compound	Dmrt7,mutant
R8640	T30854	T30850	conj	mutant,type
R8641	T30855	T30837	punct	.,concentrated
R8642	T30857	T30858	punct	(,B
R8643	T30858	T30859	meta	B,Testes
R8644	T30860	T30858	punct	),B
R8645	T30861	T30859	prep	from,Testes
R8646	T30862	T30863	nummod	6,wk
R8647	T30863	T30865	npadvmod	wk,old
R8648	T30864	T30863	punct	-,wk
R8649	T30865	T30867	amod	old,mice
R8650	T30866	T30865	punct	-,old
R8651	T30867	T30861	pobj	mice,from
R8652	T30868	T30859	acl	sectioned,Testes
R8653	T30869	T30868	cc	and,sectioned
R8654	T30870	T30868	conj	stained,sectioned
R8655	T30871	T30870	prep	with,stained
R8656	T30872	T30871	pobj	antibody,with
R8657	T30873	T30872	prep	to,antibody
R8658	T30874	T30873	pobj	γH2AX,to
R8659	T30875	T30876	punct	(,red
R8660	T30876	T30870	parataxis	red,stained
R8661	T30877	T30876	punct	),red
R8662	T30878	T30859	punct	.,Testes
R8663	T30880	T30881	punct	(,C
R8664	T30881	T30882	meta	C,Testes
R8665	T30883	T30881	punct	),C
R8666	T30884	T30882	prep	from,Testes
R8667	T30885	T30886	nummod	6,wk
R8668	T30886	T30888	npadvmod	wk,old
R8669	T30887	T30886	punct	-,wk
R8670	T30888	T30890	amod	old,mice
R8671	T30889	T30888	punct	-,old
R8672	T30890	T30884	pobj	mice,from
R8673	T30891	T30882	acl	sectioned,Testes
R8674	T30892	T30891	cc	and,sectioned
R8675	T30893	T30891	conj	stained,sectioned
R8676	T30894	T30893	prep	with,stained
R8677	T30895	T30894	pobj	antibody,with
R8678	T30896	T30895	prep	to,antibody
R8679	T30897	T30896	pobj	SUMO,to
R8680	T30898	T30897	punct	-,SUMO
R8681	T30899	T30897	nummod	1,SUMO
R8682	T30900	T30901	punct	(,green
R8683	T30901	T30893	parataxis	green,stained
R8684	T30902	T30901	punct	),green
R8685	T30903	T30882	punct	.,Testes
R8686	T30905	T30906	amod	Abundant,cells
R8687	T30906	T30908	nsubj	cells,are
R8688	T30907	T30906	compound	pachytene,cells
R8689	T30909	T30906	prep	with,cells
R8690	T30910	T30911	compound	XY,bodies
R8691	T30911	T30909	pobj	bodies,with
R8692	T30912	T30908	acomp	present,are
R8693	T30913	T30908	prep	in,are
R8694	T30914	T30915	amod	wild,type
R8695	T30915	T30917	nmod	type,testes
R8696	T30916	T30915	punct	-,type
R8697	T30917	T30913	pobj	testes,in
R8698	T30918	T30915	cc	and,type
R8699	T30919	T30915	conj	mutant,type
R8700	T30920	T30908	punct	.,are
R8703	T31607	T31608	compound	Chromatin,Abnormalities
R8704	T31609	T31608	prep	in,Abnormalities
R8705	T31610	T31611	compound	Dmrt7,Mutant
R8706	T31611	T31612	compound	Mutant,Cells
R8707	T31612	T31609	pobj	Cells,in
R8708	T31613	T31612	compound	Diplotene,Cells
R8709	T31614	T31612	compound	Germ,Cells
R8710	T31616	T31617	punct	(,A
R8711	T31617	T31618	meta	A,occurs
R8712	T31619	T31617	cc	and,A
R8713	T31620	T31617	conj	B,A
R8714	T31621	T31620	punct	),B
R8715	T31622	T31618	nsubj	MSCI,occurs
R8716	T31623	T31618	advmod	normally,occurs
R8717	T31624	T31618	prep	in,occurs
R8718	T31625	T31626	amod	mid-pachytene,spermatocyte
R8719	T31626	T31624	pobj	spermatocyte,in
R8720	T31627	T31626	prep	of,spermatocyte
R8721	T31628	T31629	compound	Dmrt7,mutant
R8722	T31629	T31627	pobj	mutant,of
R8723	T31630	T31618	punct	.,occurs
R8724	T31632	T31633	nsubj	Arrows,indicate
R8725	T31634	T31635	compound	XY,body
R8726	T31635	T31633	dobj	body,indicate
R8727	T31636	T31633	prep	in,indicate
R8728	T31637	T31638	det	all,panels
R8729	T31638	T31636	pobj	panels,in
R8730	T31639	T31633	punct	.,indicate
R8731	T31641	T31642	nmod	Cot,FISH
R8732	T31642	T31646	nsubj	FISH,reveals
R8733	T31643	T31641	punct	-,Cot
R8734	T31644	T31641	nummod	1,Cot
R8735	T31645	T31642	compound	RNA,FISH
R8736	T31647	T31648	punct	(,red
R8737	T31648	T31642	parataxis	red,FISH
R8738	T31649	T31648	punct	),red
R8739	T31650	T31651	amod	normal,silencing
R8740	T31651	T31646	dobj	silencing,reveals
R8741	T31652	T31651	prep	of,silencing
R8742	T31653	T31654	compound	sex,transcription
R8743	T31654	T31652	pobj	transcription,of
R8744	T31655	T31654	compound	chromosome,transcription
R8745	T31656	T31654	prep	in,transcription
R8746	T31657	T31658	compound	XY,body
R8747	T31658	T31656	pobj	body,in
R8748	T31659	T31646	punct	.,reveals
R8749	T31661	T31662	nsubj	This,is
R8750	T31663	T31662	acomp	consistent,is
R8751	T31664	T31663	prep	with,consistent
R8752	T31665	T31666	amod	wild,type
R8753	T31666	T31668	compound	type,mid-pachynema
R8754	T31667	T31666	punct	-,type
R8755	T31668	T31664	pobj	mid-pachynema,with
R8756	T31669	T31670	mark	as,described
R8757	T31670	T31662	advcl	described,is
R8758	T31671	T31670	advmod	previously,described
R8759	T31672	T31673	punct	[,16
R8760	T31673	T31662	parataxis	16,is
R8761	T31674	T31673	punct	],16
R8762	T31675	T31662	punct	.,is
R8763	T31677	T31678	punct	(,C
R8764	T31678	T31679	meta	C,localization
R8765	T31680	T31678	cc	and,C
R8766	T31681	T31678	conj	D,C
R8767	T31682	T31681	punct	),D
R8768	T31683	T31679	compound	HP1β,localization
R8769	T31684	T31679	prep	in,localization
R8770	T31685	T31686	amod	mid-pachytene,spermatocytes
R8771	T31686	T31684	pobj	spermatocytes,in
R8772	T31687	T31679	punct	.,localization
R8773	T31689	T31690	nsubj	HP1β,localizes
R8774	T31691	T31690	prep	to,localizes
R8775	T31692	T31693	compound	X,chromosome
R8776	T31693	T31694	compound	chromosome,centromere
R8777	T31694	T31691	pobj	centromere,to
R8778	T31695	T31696	punct	(,arrowhead
R8779	T31696	T31690	parataxis	arrowhead,localizes
R8780	T31697	T31696	punct	),arrowhead
R8781	T31698	T31690	prep	in,localizes
R8782	T31699	T31700	amod	wild,type
R8783	T31700	T31698	pobj	type,in
R8784	T31701	T31700	punct	-,type
R8785	T31702	T31703	punct	(,C
R8786	T31703	T31700	parataxis	C,type
R8787	T31704	T31703	punct	),C
R8788	T31705	T31700	cc	and,type
R8789	T31706	T31700	conj	mutant,type
R8790	T31707	T31708	punct	(,D
R8791	T31708	T31706	parataxis	D,mutant
R8792	T31709	T31708	punct	),D
R8793	T31710	T31690	punct	.,localizes
R8794	T31712	T31713	punct	(,E
R8795	T31713	T31714	meta	E,hybridization
R8796	T31715	T31713	cc	and,E
R8797	T31716	T31713	conj	F,E
R8798	T31717	T31716	punct	),F
R8799	T31718	T31714	nmod	Cot,hybridization
R8800	T31719	T31718	punct	-,Cot
R8801	T31720	T31718	nummod	1,Cot
R8802	T31721	T31714	prep	in,hybridization
R8803	T31722	T31721	pobj	diplotene,in
R8804	T31723	T31714	punct	.,hybridization
R8805	T31725	T31726	amod	Presumptive,body
R8806	T31726	T31728	nsubjpass	body,indicated
R8807	T31727	T31726	compound	XY,body
R8808	T31729	T31728	punct	", ",indicated
R8809	T31730	T31728	prep	based,indicated
R8810	T31731	T31730	prep	on,based
R8811	T31732	T31733	nmod	DAPI,localization
R8812	T31733	T31731	pobj	localization,on
R8813	T31734	T31732	cc	and,DAPI
R8814	T31735	T31732	conj	γH2AX,DAPI
R8815	T31736	T31728	punct	", ",indicated
R8816	T31737	T31728	auxpass	is,indicated
R8817	T31738	T31728	agent	by,indicated
R8818	T31739	T31738	pobj	arrow,by
R8819	T31740	T31739	prep	in,arrow
R8820	T31741	T31742	punct	(,F
R8821	T31742	T31740	pobj	F,in
R8822	T31743	T31728	punct	),indicated
R8823	T31744	T31728	punct	.,indicated
R8824	T31746	T31747	punct	(,G
R8825	T31747	T31748	meta	G,HP1β
R8826	T31749	T31747	cc	and,G
R8827	T31750	T31747	conj	H,G
R8828	T31751	T31750	punct	),H
R8829	T31752	T31748	prep	in,HP1β
R8830	T31753	T31752	pobj	diplotene,in
R8831	T31754	T31748	punct	.,HP1β
R8832	T31756	T31757	amod	Wild,type
R8833	T31757	T31759	compound	type,cell
R8834	T31758	T31757	punct	-,type
R8835	T31759	T31760	nsubj	cell,has
R8836	T31761	T31762	punct	(,E
R8837	T31762	T31759	parataxis	E,cell
R8838	T31763	T31762	punct	),E
R8839	T31764	T31760	dobj	HP1β,has
R8840	T31765	T31760	prep	throughout,has
R8841	T31766	T31767	compound	XY,body
R8842	T31767	T31765	pobj	body,throughout
R8843	T31768	T31760	punct	", ",has
R8844	T31769	T31770	mark	whereas,has
R8845	T31770	T31760	advcl	has,has
R8846	T31771	T31772	compound	mutant,cell
R8847	T31772	T31770	nsubj	cell,has
R8848	T31773	T31774	punct	(,H
R8849	T31774	T31772	parataxis	H,cell
R8850	T31775	T31774	punct	),H
R8851	T31776	T31770	advmod	only,has
R8852	T31777	T31770	dobj	localization,has
R8853	T31778	T31777	prep	to,localization
R8854	T31779	T31780	compound	X,chromosome
R8855	T31780	T31781	compound	chromosome,centromere
R8856	T31781	T31778	pobj	centromere,to
R8857	T31782	T31783	punct	(,arrowhead
R8858	T31783	T31777	parataxis	arrowhead,localization
R8859	T31784	T31783	punct	),arrowhead
R8860	T31785	T31760	punct	.,has
R8861	T31787	T31788	punct	(,I
R8862	T31788	T31789	meta	I,localization
R8863	T31790	T31788	cc	and,I
R8864	T31791	T31788	conj	J,I
R8865	T31792	T31791	punct	),J
R8866	T31793	T31794	compound	H3,2meK9
R8867	T31794	T31789	compound	2meK9,localization
R8868	T31795	T31794	punct	-,2meK9
R8869	T31796	T31789	prep	in,localization
R8870	T31797	T31798	compound	diplotene,cells
R8871	T31798	T31796	pobj	cells,in
R8872	T31799	T31789	punct	.,localization
R8873	T31801	T31802	compound	Mutant,cell
R8874	T31802	T31803	nsubj	cell,lacks
R8875	T31804	T31805	punct	(,J
R8876	T31805	T31802	parataxis	J,cell
R8877	T31806	T31805	punct	),J
R8878	T31807	T31808	amod	strong,concentration
R8879	T31808	T31803	dobj	concentration,lacks
R8880	T31809	T31808	prep	of,concentration
R8881	T31810	T31811	det	this,mark
R8882	T31811	T31809	pobj	mark,of
R8883	T31812	T31808	prep	to,concentration
R8884	T31813	T31814	det	the,body
R8885	T31814	T31812	pobj	body,to
R8886	T31815	T31814	compound	XY,body
R8887	T31816	T31814	acl	seen,body
R8888	T31817	T31816	prep	in,seen
R8889	T31818	T31819	amod	wild,type
R8890	T31819	T31817	pobj	type,in
R8891	T31820	T31819	punct	-,type
R8892	T31821	T31822	punct	(,I
R8893	T31822	T31803	parataxis	I,lacks
R8894	T31823	T31822	punct	),I
R8895	T31824	T31803	punct	.,lacks
R8896	T31826	T31827	punct	(,K
R8897	T31827	T31828	meta	K,localization
R8898	T31829	T31827	cc	and,K
R8899	T31830	T31827	conj	L,K
R8900	T31831	T31830	punct	),L
R8901	T31832	T31833	compound	H3,3meK9
R8902	T31833	T31828	compound	3meK9,localization
R8903	T31834	T31833	punct	-,3meK9
R8904	T31835	T31828	prep	in,localization
R8905	T31836	T31837	compound	diplotene,cells
R8906	T31837	T31835	pobj	cells,in
R8907	T31838	T31828	punct	.,localization
R8908	T31840	T31841	compound	Mutant,cell
R8909	T31841	T31842	nsubj	cell,has
R8910	T31843	T31844	punct	(,L
R8911	T31844	T31841	parataxis	L,cell
R8912	T31845	T31844	punct	),L
R8913	T31846	T31847	det	no,localization
R8914	T31847	T31842	dobj	localization,has
R8915	T31848	T31847	prep	of,localization
R8916	T31849	T31850	det	this,mark
R8917	T31850	T31848	pobj	mark,of
R8918	T31851	T31847	prep	to,localization
R8919	T31852	T31853	det	the,body
R8920	T31853	T31851	pobj	body,to
R8921	T31854	T31853	compound	XY,body
R8922	T31855	T31842	punct	.,has
R8923	T31857	T31858	nsubj	γH2AX,localizes
R8924	T31859	T31858	prep	to,localizes
R8925	T31860	T31859	pobj	autosomes,to
R8926	T31861	T31858	prep	in,localizes
R8927	T31862	T31863	compound	mutant,cell
R8928	T31863	T31861	pobj	cell,in
R8929	T31864	T31858	punct	", ",localizes
R8930	T31865	T31866	advmod	possibly,indicating
R8931	T31866	T31858	advcl	indicating,localizes
R8932	T31867	T31866	dobj	onset,indicating
R8933	T31868	T31867	prep	of,onset
R8934	T31869	T31868	pobj	apoptosis,of
R8935	T31870	T31858	punct	.,localizes
R8936	T31872	T31873	punct	(,M
R8937	T31873	T31874	meta	M,Example
R8938	T31875	T31873	punct	),M
R8939	T31876	T31874	prep	of,Example
R8940	T31877	T31878	compound	mutant,cell
R8941	T31878	T31876	pobj	cell,of
R8942	T31879	T31878	compound	diplotene,cell
R8943	T31880	T31878	prep	with,cell
R8944	T31881	T31882	amod	normal,accumulation
R8945	T31882	T31880	pobj	accumulation,with
R8946	T31883	T31882	compound	HP1β,accumulation
R8947	T31884	T31882	prep	to,accumulation
R8948	T31885	T31886	det	the,body
R8949	T31886	T31884	pobj	body,to
R8950	T31887	T31886	compound	XY,body
R8951	T31888	T31874	punct	.,Example
R8952	T31890	T31891	det	All,images
R8953	T31891	T31892	nsubj	images,are
R8954	T31893	T31891	prep	except,images
R8955	T31894	T31893	pobj	those,except
R8956	T31895	T31894	prep	in,those
R8957	T31896	T31897	punct	(,M
R8958	T31897	T31895	pobj	M,in
R8959	T31898	T31892	punct	),are
R8960	T31899	T31900	amod	single,Z
R8961	T31900	T31901	compound	Z,sections
R8962	T31901	T31892	attr	sections,are
R8963	T31902	T31892	punct	.,are
R8964	T32100	T32101	amod	Abnormal,Chromatin
R8965	T32102	T32101	compound	Sex,Chromatin
R8966	T32103	T32101	prep	in,Chromatin
R8967	T32104	T32103	pobj	Cells,in
R8968	T32105	T32101	acl	Staged,Chromatin
R8969	T32106	T32105	prep	by,Staged
R8970	T32107	T32108	nmod	Chromosome,Status
R8971	T32108	T32106	pobj	Status,by
R8972	T32109	T32108	amod	Pairing,Status
R8973	T32111	T32112	punct	(,A
R8974	T32112	T32113	meta	A,Spread
R8975	T32114	T32112	punct	),A
R8976	T32115	T32113	prep	of,Spread
R8977	T32116	T32117	amod	wild,type
R8978	T32117	T32119	compound	type,cell
R8979	T32118	T32117	punct	-,type
R8980	T32119	T32115	pobj	cell,of
R8981	T32120	T32119	compound	germ,cell
R8982	T32121	T32119	acl	stained,cell
R8983	T32122	T32121	prep	with,stained
R8984	T32123	T32122	pobj	DAPI,with
R8985	T32124	T32123	punct	", ",DAPI
R8986	T32125	T32123	amod	anti-SYCP3,DAPI
R8987	T32126	T32123	punct	", ",DAPI
R8988	T32127	T32123	cc	and,DAPI
R8989	T32128	T32123	conj	anti-HP1β,DAPI
R8990	T32129	T32113	acl	showing,Spread
R8991	T32130	T32131	compound	chromosome,morphology
R8992	T32131	T32129	dobj	morphology,showing
R8993	T32132	T32131	amod	typical,morphology
R8994	T32133	T32132	prep	of,typical
R8995	T32134	T32133	pobj	diplonema,of
R8996	T32135	T32131	cc	and,morphology
R8997	T32136	T32137	amod	internalized,body
R8998	T32137	T32131	conj	body,morphology
R8999	T32138	T32137	compound	XY,body
R9000	T32139	T32137	prep	with,body
R9001	T32140	T32141	compound	HP1β,accumulation
R9002	T32141	T32139	pobj	accumulation,with
R9003	T32142	T32113	punct	.,Spread
R9004	T32144	T32145	punct	(,B
R9005	T32145	T32146	meta	B,Spread
R9006	T32147	T32145	punct	),B
R9007	T32148	T32146	prep	of,Spread
R9008	T32149	T32150	compound	Dmrt7,mutant
R9009	T32150	T32151	compound	mutant,cell
R9010	T32151	T32148	pobj	cell,of
R9011	T32152	T32151	compound	germ,cell
R9012	T32153	T32146	acl	showing,Spread
R9013	T32154	T32155	amod	normal,morphology
R9014	T32155	T32153	dobj	morphology,showing
R9015	T32156	T32155	compound	diplotene,morphology
R9016	T32157	T32155	compound	chromosome,morphology
R9017	T32158	T32155	cc	and,morphology
R9018	T32159	T32160	amod	internalized,body
R9019	T32160	T32155	conj	body,morphology
R9020	T32161	T32160	compound	XY,body
R9021	T32162	T32155	punct	", ",morphology
R9022	T32163	T32155	cc	but,morphology
R9023	T32164	T32165	det	no,accumulation
R9024	T32165	T32155	conj	accumulation,morphology
R9025	T32166	T32165	compound	HP1β,accumulation
R9026	T32167	T32165	prep	in,accumulation
R9027	T32168	T32169	det	the,body
R9028	T32169	T32167	pobj	body,in
R9029	T32170	T32169	compound	XY,body
R9030	T32171	T32146	punct	.,Spread
R9031	T32173	T32174	compound	XY,pairs
R9032	T32174	T32176	nsubjpass	pairs,indicated
R9033	T32175	T32174	compound	chromosome,pairs
R9034	T32177	T32176	auxpass	are,indicated
R9035	T32178	T32176	agent	by,indicated
R9036	T32179	T32178	pobj	arrow,by
R9037	T32180	T32176	punct	.,indicated
R49	T836	T834	attr	process,is
R50	T943	T944	mark	that,localizes
R5	T817	T818	npadvmod	Mammal,Specific
R8	T818	T815	amod	Specific,Homolog
R9	T819	T818	punct	-,Specific
R10	T820	T815	compound	Doublesex,Homolog
R11	T822	T821	prep	with,Associates
R12	T914	T915	advmod	Here,investigate
R13	T823	T824	amod	Male,Chromatin
R14	T824	T822	pobj	Chromatin,with
R15	T916	T915	punct	", ",investigate
R16	T825	T824	compound	Sex,Chromatin
R17	T917	T915	nsubj	we,investigate
R18	T918	T919	det	the,function
R19	T919	T915	dobj	function,investigate
R20	T826	T821	cc	and,Associates
R21	T920	T919	prep	of,function
R22	T921	T920	pobj	DMRT7,of
R23	T827	T828	auxpass	Is,Required
R24	T922	T921	punct	", ",DMRT7
R25	T923	T924	det	a,protein
R26	T828	T821	conj	Required,Associates
R27	T924	T921	appos	protein,DMRT7
R28	T925	T926	npadvmod	mammal,specific
R29	T829	T828	prep	for,Required
R30	T926	T924	amod	specific,protein
R31	T927	T926	punct	-,specific
R32	T928	T924	acl	related,protein
R33	T929	T928	prep	to,related
R34	T830	T831	amod	Male,Meiosis
R35	T930	T931	det	the,regulators
R36	T931	T929	pobj	regulators,to
R37	T932	T931	nmod	invertebrate,regulators
R38	T831	T829	pobj	Meiosis,for
R39	T933	T931	amod	sexual,regulators
R40	T934	T931	appos	Doublesex,regulators
R41	T833	T834	nsubj	Gametogenesis,is
R42	T935	T934	cc	and,Doublesex
R43	T936	T934	conj	MAB,Doublesex
R44	T937	T936	punct	-,MAB
R45	T938	T936	nummod	3,MAB
R46	T835	T836	det	a,process
R47	T939	T915	punct	.,investigate
R48	T941	T942	nsubj	We,find
R51	T837	T838	advmod	sexually,dimorphic
R52	T944	T942	ccomp	localizes,find
R53	T945	T944	nsubj	DMRT7,localizes
R54	T946	T944	advmod	preferentially,localizes
R55	T947	T944	prep	to,localizes
R56	T948	T949	det	the,body
R57	T949	T947	pobj	body,to
R58	T838	T836	amod	dimorphic,process
R59	T950	T949	compound	XY,body
R60	T951	T944	prep	in,localizes
R61	T952	T953	det	the,stage
R62	T839	T836	acl	requiring,process
R63	T953	T951	pobj	stage,in
R64	T954	T953	compound	pachytene,stage
R65	T840	T841	amod	profound,differences
R66	T955	T953	prep	of,stage
R67	T956	T957	amod	meiotic,prophase
R68	T957	T955	pobj	prophase,of
R69	T841	T839	dobj	differences,requiring
R70	T958	T944	cc	and,localizes
R71	T959	T960	auxpass	is,required
R72	T960	T944	conj	required,localizes
R73	T842	T841	prep	in,differences
R74	T961	T960	prep	for,required
R75	T843	T844	compound	germ,cell
R76	T962	T963	amod	male,meiosis
R77	T844	T845	compound	cell,differentiation
R78	T963	T961	pobj	meiosis,for
R79	T964	T942	punct	.,find
R80	T845	T842	pobj	differentiation,in
R81	T966	T967	prep	In,appear
R82	T846	T841	prep	between,differences
R83	T968	T969	compound	Dmrt7,mutants
R84	T969	T966	pobj	mutants,In
R85	T847	T848	det	the,sexes
R86	T970	T967	punct	", ",appear
R87	T971	T972	amod	meiotic,pairing
R88	T848	T846	pobj	sexes,between
R89	T972	T967	nsubj	pairing,appear
R90	T973	T972	cc	and,pairing
R91	T849	T834	punct	.,is
R92	T974	T972	conj	recombination,pairing
R93	T975	T967	oprd	normal,appear
R94	T976	T967	punct	", ",appear
R95	T851	T852	prep	In,creates
R96	T977	T967	cc	and,appear
R97	T978	T979	det	a,body
R98	T979	T983	nsubjpass	body,formed
R99	T853	T851	pobj	mammals,In
R100	T980	T981	advmod	transcriptionally,silenced
R101	T981	T979	amod	silenced,body
R102	T982	T979	compound	XY,body
R103	T854	T852	punct	", ",creates
R104	T983	T967	conj	formed,appear
R105	T984	T979	prep	with,body
R106	T985	T986	amod	appropriate,marks
R107	T986	T984	pobj	marks,with
R108	T855	T856	det	the,presence
R109	T987	T986	compound	chromatin,marks
R110	T988	T983	auxpass	is,formed
R111	T989	T967	punct	", ",appear
R112	T856	T852	nsubj	presence,creates
R113	T990	T967	cc	but,appear
R114	T991	T992	amod	most,cells
R115	T857	T856	prep	of,presence
R116	T992	T994	nsubj	cells,undergo
R117	T858	T859	amod	heteromorphic,chromosomes
R118	T859	T857	pobj	chromosomes,of
R119	T993	T992	compound	germ,cells
R120	T994	T967	conj	undergo,appear
R121	T860	T859	compound	sex,chromosomes
R122	T995	T994	dobj	apoptosis,undergo
R123	T996	T994	prep	during,undergo
R124	T997	T996	pobj	pachynema,during
R125	T861	T859	prep	in,chromosomes
R126	T998	T994	punct	.,undergo
R127	T1000	T1001	det	A,minority
R128	T1001	T1002	nsubj	minority,progress
R129	T862	T861	pobj	males,in
R130	T1003	T1001	prep	of,minority
R131	T1004	T1005	compound	mutant,cells
R132	T863	T864	amod	additional,challenges
R133	T1005	T1003	pobj	cells,of
R134	T1006	T1002	aux	can,progress
R135	T1007	T1002	prep	to,progress
R136	T864	T852	dobj	challenges,creates
R137	T1008	T1007	pobj	diplonema,to
R138	T1009	T1002	punct	", ",progress
R139	T1010	T1002	cc	but,progress
R140	T865	T866	npadvmod	sex,specific
R141	T1011	T1012	nsubj	many,have
R142	T1012	T1002	conj	have,progress
R143	T1013	T1011	prep	of,many
R144	T1014	T1015	det	these,cells
R145	T866	T864	amod	specific,challenges
R146	T1015	T1013	pobj	cells,of
R147	T1016	T1015	amod	escaping,cells
R148	T1017	T1018	amod	abnormal,chromatin
R149	T867	T866	punct	-,specific
R150	T1018	T1012	dobj	chromatin,have
R151	T868	T864	punct	", ",challenges
R152	T869	T864	prep	including,challenges
R153	T870	T871	amod	incomplete,pairing
R154	T871	T869	pobj	pairing,including
R155	T1019	T1018	compound	sex,chromatin
R156	T1020	T1018	acl	lacking,chromatin
R157	T1021	T1022	nmod	histone,trimethylation
R158	T1022	T1020	dobj	trimethylation,lacking
R159	T1023	T1022	nmod	H3K9,trimethylation
R160	T1024	T1022	nmod	di,trimethylation
R161	T1025	T1022	punct	-,trimethylation
R162	T872	T871	nmod	X,pairing
R163	T1026	T1022	cc	and,trimethylation
R164	T1027	T1022	cc	and,trimethylation
R165	T1028	T1029	compound	heterochromatin,accumulation
R166	T873	T872	cc	and,X
R167	T1029	T1022	conj	accumulation,trimethylation
R168	T1030	T1029	compound	protein,accumulation
R169	T1031	T1029	compound	1β,accumulation
R170	T1032	T1018	punct	", ",chromatin
R171	T874	T872	conj	Y,X
R172	T1033	T1018	appos	modifications,chromatin
R173	T1034	T1035	dep	that,occur
R174	T1035	T1033	relcl	occur,modifications
R175	T875	T852	prep	during,creates
R176	T1036	T1035	advmod	normally,occur
R177	T1037	T1035	prep	between,occur
R178	T1038	T1037	pobj	pachynema,between
R179	T876	T877	amod	meiotic,prophase
R180	T1039	T1038	cc	and,pachynema
R181	T1040	T1038	conj	diplonema,pachynema
R182	T1041	T1012	punct	.,have
R183	T877	T875	pobj	prophase,during
R184	T1043	T1044	prep	Based,conclude
R185	T878	T852	punct	.,creates
R186	T1045	T1043	prep	on,Based
R187	T1046	T1047	det	the,localization
R188	T880	T881	nsubj	This,triggers
R189	T1047	T1045	pobj	localization,on
R190	T882	T881	dobj	formation,triggers
R191	T1048	T1047	prep	of,localization
R192	T1049	T1048	pobj	DMRT7,of
R193	T1050	T1047	prep	to,localization
R194	T1051	T1052	det	the,body
R195	T883	T882	prep	of,formation
R196	T1052	T1050	pobj	body,to
R197	T1053	T1052	compound	XY,body
R198	T1054	T1047	cc	and,localization
R199	T884	T885	det	a,domain
R200	T1055	T1056	det	the,defects
R201	T1056	T1047	conj	defects,localization
R202	T1057	T1058	compound	sex,chromatin
R203	T885	T883	pobj	domain,of
R204	T1058	T1056	compound	chromatin,defects
R205	T1059	T1056	acl	observed,defects
R206	T1060	T1059	prep	in,observed
R207	T886	T885	compound	heterochromatin,domain
R208	T1061	T1062	compound	Dmrt7,mutants
R209	T1062	T1060	pobj	mutants,in
R210	T1063	T1044	punct	", ",conclude
R211	T887	T885	punct	", ",domain
R212	T1064	T1044	nsubj	we,conclude
R213	T1065	T1066	mark	that,plays
R214	T1066	T1044	ccomp	plays,conclude
R215	T1067	T1066	nsubj	DMRT7,plays
R216	T888	T889	det	the,body
R217	T1068	T1069	det	a,role
R218	T1069	T1066	dobj	role,plays
R219	T1070	T1066	prep	in,plays
R220	T1071	T1072	det	the,transformation
R221	T1072	T1070	pobj	transformation,in
R222	T889	T885	appos	body,domain
R223	T1073	T1074	compound	sex,chromatin
R224	T1074	T1072	compound	chromatin,transformation
R225	T1075	T1076	dep	that,occurs
R226	T890	T889	compound	XY,body
R227	T1076	T1072	relcl	occurs,transformation
R228	T1077	T1076	prep	between,occurs
R229	T1078	T1077	pobj	pachynema,between
R230	T1079	T1078	cc	and,pachynema
R231	T891	T881	punct	.,triggers
R232	T1080	T1078	conj	diplonema,pachynema
R233	T1081	T1044	punct	.,conclude
R234	T893	T894	det	The,body
R235	T1083	T1084	nsubj	We,suggest
R236	T1085	T1086	mark	that,help
R237	T894	T896	nsubj	body,disassembles
R238	T1086	T1084	ccomp	help,suggest
R239	T1087	T1086	nsubj	DMRT7,help
R240	T1088	T1086	aux	may,help
R241	T1089	T1086	xcomp	control,help
R242	T895	T894	compound	XY,body
R243	T1090	T1091	det	the,transition
R244	T1091	T1089	dobj	transition,control
R245	T1092	T1091	prep	from,transition
R246	T897	T896	prep	after,disassembles
R247	T1093	T1094	amod	meiotic,chromosome
R248	T1094	T1096	compound	chromosome,inactivation
R249	T1095	T1094	compound	sex,chromosome
R250	T898	T897	pobj	prophase,after
R251	T899	T896	punct	", ",disassembles
R252	T900	T896	cc	but,disassembles
R253	T1096	T1092	pobj	inactivation,from
R254	T1097	T1091	prep	to,transition
R255	T901	T902	amod	specialized,chromatin
R256	T1098	T1099	amod	postmeiotic,chromatin
R257	T1099	T1097	pobj	chromatin,to
R258	T1100	T1099	compound	sex,chromatin
R259	T902	T904	nsubj	chromatin,persists
R260	T1101	T1091	prep	in,transition
R261	T1102	T1101	pobj	males,in
R262	T1103	T1084	punct	.,suggest
R263	T903	T902	compound	sex,chromatin
R264	T1105	T1106	prep	In,shed
R265	T904	T896	conj	persists,disassembles
R266	T1107	T1105	pobj	addition,In
R267	T1108	T1106	punct	", ",shed
R268	T1109	T1110	mark	because,found
R269	T1110	T1106	advcl	found,shed
R270	T1111	T1110	nsubjpass	it,found
R271	T905	T904	punct	", ",persists
R272	T1112	T1110	auxpass	is,found
R273	T1113	T1110	prep	in,found
R274	T1114	T1115	det	all,branches
R275	T1115	T1113	pobj	branches,in
R276	T906	T904	prep	with,persists
R277	T1116	T1115	prep	of,branches
R278	T1117	T1116	pobj	mammals,of
R279	T1118	T1113	punct	", ",in
R280	T1119	T1113	cc	but,in
R281	T907	T908	amod	further,modification
R282	T1120	T1119	neg	not,but
R283	T1121	T1113	conj	in,in
R284	T1122	T1123	amod	other,vertebrates
R285	T908	T906	pobj	modification,with
R289	T909	T904	punct	", ",persists
R290	T910	T904	prep	through,persists
R291	T1126	T1106	aux	may,shed
R292	T1127	T1106	dobj	light,shed
R293	T911	T910	pobj	meiosis,through
R294	T1128	T1106	prep	on,shed
R295	T1129	T1128	pobj	evolution,on
R296	T1130	T1129	prep	of,evolution
R297	T912	T904	punct	.,persists
R298	T1131	T1130	pobj	meiosis,of
R299	T814	T815	det	A,Homolog
R300	T1132	T1130	cc	and,of
R301	T1133	T1130	conj	of,of
R302	T1134	T1135	compound	sex,chromatin
R303	T1135	T1133	pobj	chromatin,of
R304	T1136	T1106	punct	.,shed
R305	T815	T821	nsubj	Homolog,Associates
R313	T4035	T4033	pobj	sexes,between
R314	T3987	T3988	amod	Sexual,differentiation
R315	T3988	T3989	nsubj	differentiation,generates
R316	T3990	T3991	amod	anatomical,dimorphisms
R317	T4036	T4032	prep	in,differ
R318	T3991	T3989	dobj	dimorphisms,generates
R319	T3992	T3990	punct	", ",anatomical
R320	T3993	T3990	conj	physiological,anatomical
R321	T4037	T4036	pobj	size,in
R322	T3994	T3993	punct	", ",physiological
R323	T3995	T3993	cc	and,physiological
R324	T4038	T4037	cc	and,size
R325	T4039	T4037	conj	morphology,size
R326	T3996	T3993	conj	behavioral,physiological
R327	T4040	T4032	punct	", ",differ
R328	T3997	T3998	dep	that,are
R329	T3998	T3991	relcl	are,dimorphisms
R330	T4041	T4042	advmod	sometimes,so
R331	T3999	T3998	acomp	essential,are
R332	T4000	T3999	prep	for,essential
R333	T4001	T4002	amod	sexual,reproduction
R334	T4042	T4032	advmod	so,differ
R335	T4002	T4000	pobj	reproduction,for
R336	T4003	T3989	punct	.,generates
R337	T4043	T4042	advmod	dramatically,so
R338	T4005	T4006	nsubj	Many,affect
R339	T4044	T4032	punct	", ",differ
R340	T4007	T4005	prep	of,Many
R341	T4008	T4009	det	these,dimorphisms
R342	T4009	T4007	pobj	dimorphisms,of
R343	T4045	T4032	advcl	reflecting,differ
R344	T4010	T4011	amod	somatic,cells
R345	T4011	T4006	dobj	cells,affect
R346	T4012	T4006	punct	", ",affect
R347	T4046	T4047	poss	their,roles
R348	T4013	T4006	cc	but,affect
R349	T4014	T4015	det	the,dimorphisms
R350	T4015	T4017	nsubj	dimorphisms,are
R351	T4047	T4045	dobj	roles,reflecting
R352	T4016	T4015	amod	sexual,dimorphisms
R353	T4048	T4049	advmod	very,different
R354	T4017	T4006	conj	are,affect
R355	T4018	T4019	dep	that,mediate
R356	T4049	T4047	amod	different,roles
R357	T4019	T4015	relcl	mediate,dimorphisms
R358	T4020	T4021	advmod	most,directly
R359	T4021	T4019	advmod	directly,mediate
R360	T4022	T4023	amod	sexual,reproduction
R361	T4023	T4019	dobj	reproduction,mediate
R362	T4024	T4017	attr	those,are
R363	T4025	T4024	prep	of,those
R364	T4026	T4027	det	the,gametes
R365	T4027	T4025	pobj	gametes,of
R366	T4028	T4027	appos	themselves,gametes
R367	T4029	T4017	punct	.,are
R368	T4031	T4032	nsubj	Gametes,differ
R369	T4033	T4032	prep	between,differ
R370	T4034	T4035	det	the,sexes
R371	T4050	T4047	prep	in,roles
R372	T4051	T4052	compound	zygote,formation
R373	T4141	T4140	prep	during,arrest
R374	T4052	T4050	pobj	formation,in
R375	T4142	T4143	amod	meiotic,prophase
R376	T4143	T4141	pobj	prophase,during
R377	T4144	T4143	nummod	I,prophase
R378	T4053	T4032	punct	.,differ
R379	T4145	T4129	punct	.,initiate
R380	T4055	T4056	advmod	Indeed,is
R381	T4147	T4148	prep	After,recruited
R382	T4149	T4147	pobj	puberty,After
R383	T4150	T4148	punct	", ",recruited
R384	T4056	T4063	ccomp	is,are
R385	T4151	T4148	nsubjpass	oocytes,recruited
R386	T4152	T4148	auxpass	are,recruited
R387	T4153	T4148	advmod	selectively,recruited
R388	T4154	T4148	prep	for,recruited
R389	T4057	T4056	punct	", ",is
R390	T4155	T4154	pobj	ovulation,for
R391	T4156	T4148	punct	", ",recruited
R392	T4157	T4158	advmod	when,proceed
R393	T4158	T4148	advcl	proceed,recruited
R394	T4159	T4158	nsubj	they,proceed
R395	T4058	T4059	det	the,morphology
R396	T4160	T4158	prep	to,proceed
R397	T4161	T4160	pobj	metaphase,to
R398	T4162	T4161	nummod	II,metaphase
R399	T4163	T4148	cc	and,recruited
R400	T4059	T4056	nsubj	morphology,is
R401	T4164	T4165	advmod	then,complete
R402	T4165	T4148	conj	complete,recruited
R403	T4060	T4059	prep	of,morphology
R404	T4166	T4165	dobj	meiosis,complete
R405	T4167	T4168	mark	after,occurs
R406	T4168	T4165	advcl	occurs,complete
R407	T4061	T4062	det	the,gametes
R408	T4169	T4168	nsubj	fertilization,occurs
R409	T4170	T4171	punct	[,2
R410	T4171	T4165	parataxis	2,complete
R411	T4172	T4171	punct	],2
R412	T4173	T4148	punct	.,recruited
R413	T4175	T4176	prep	In,occurs
R414	T4062	T4060	pobj	gametes,of
R415	T4177	T4175	pobj	contrast,In
R416	T4178	T4176	punct	", ",occurs
R417	T4064	T4065	dep	what,defines
R418	T4179	T4180	amod	male,meiosis
R419	T4180	T4176	nsubj	meiosis,occurs
R420	T4181	T4182	advmod	entirely,postnatally
R421	T4182	T4176	advmod	postnatally,occurs
R422	T4065	T4056	ccomp	defines,is
R423	T4183	T4176	punct	", ",occurs
R424	T4184	T4176	prep	without,occurs
R425	T4066	T4065	dobj	sex,defines
R426	T4185	T4186	det	the,periods
R427	T4186	T4184	pobj	periods,without
R428	T4187	T4186	compound	arrest,periods
R429	T4067	T4063	punct	: ,are
R430	T4188	T4186	acl	found,periods
R431	T4189	T4188	prep	in,found
R432	T4190	T4189	pobj	females,in
R433	T4068	T4063	nsubj	females,are
R434	T4069	T4070	det	the,sex
R435	T4191	T4176	punct	.,occurs
R436	T4070	T4063	attr	sex,are
R437	T4193	T4194	prep	In,produce
R438	T4195	T4193	pobj	females,In
R439	T4071	T4072	dep	that,produces
R440	T4196	T4194	punct	", ",produce
R441	T4197	T4198	det	each,meiosis
R442	T4072	T4070	relcl	produces,sex
R443	T4198	T4194	nsubj	meiosis,produce
R444	T4073	T4074	det	the,gametes
R445	T4074	T4072	dobj	gametes,produces
R446	T4075	T4074	amod	larger,gametes
R447	T4199	T4194	aux	can,produce
R448	T4076	T4063	cc	and,are
R449	T4200	T4201	det	a,oocyte
R450	T4077	T4078	nsubj	males,produce
R451	T4201	T4194	dobj	oocyte,produce
R452	T4202	T4201	amod	single,oocyte
R453	T4203	T4201	compound	haploid,oocyte
R454	T4078	T4063	conj	produce,are
R455	T4204	T4201	punct	(,oocyte
R456	T4205	T4201	cc	and,oocyte
R457	T4079	T4080	det	the,ones
R458	T4206	T4207	nummod	two,bodies
R459	T4207	T4201	conj	bodies,oocyte
R460	T4208	T4207	amod	extruded,bodies
R461	T4080	T4078	dobj	ones,produce
R462	T4209	T4207	amod	polar,bodies
R463	T4210	T4194	punct	),produce
R464	T4211	T4194	punct	", ",produce
R465	T4212	T4213	mark	whereas,produce
R466	T4213	T4194	advcl	produce,produce
R467	T4214	T4215	det	each,meiosis
R468	T4081	T4080	amod	smaller,ones
R469	T4215	T4213	nsubj	meiosis,produce
R470	T4216	T4215	amod	male,meiosis
R471	T4217	T4213	aux	can,produce
R472	T4218	T4219	nummod	four,spermatocytes
R473	T4082	T4063	punct	.,are
R474	T4219	T4213	dobj	spermatocytes,produce
R475	T4220	T4219	compound	haploid,spermatocytes
R476	T4221	T4194	punct	.,produce
R477	T4084	T4085	amod	Mammalian,meiosis
R478	T4223	T4224	amod	Other,processes
R479	T4224	T4226	nsubj	processes,occur
R480	T4225	T4224	amod	meiotic,processes
R481	T4227	T4224	punct	", ",processes
R482	T4228	T4229	amod	such,as
R483	T4085	T4086	nsubjpass	meiosis,regulated
R484	T4229	T4224	prep	as,processes
R485	T4230	T4229	pobj	recombination,as
R486	T4231	T4230	cc	and,recombination
R487	T4232	T4233	compound	chromosome,pairing
R488	T4233	T4230	conj	pairing,recombination
R489	T4087	T4086	auxpass	is,regulated
R490	T4234	T4235	punct	(,synapsis
R491	T4235	T4233	parataxis	synapsis,pairing
R492	T4236	T4235	punct	),synapsis
R493	T4237	T4226	punct	", ",occur
R494	T4238	T4226	prep	in,occur
R495	T4088	T4089	npadvmod	sex,specifically
R496	T4239	T4240	preconj	both,sexes
R497	T4240	T4238	pobj	sexes,in
R498	T4241	T4226	cc	but,occur
R499	T4089	T4086	advmod	specifically,regulated
R500	T4242	T4226	conj	operate,occur
R501	T4243	T4244	advmod	somewhat,differently
R502	T4244	T4242	advmod	differently,operate
R503	T4090	T4089	punct	-,specifically
R504	T4245	T4226	punct	.,occur
R505	T4091	T4086	advcl	starting,regulated
R506	T4092	T4091	prep	in,starting
R507	T4093	T4092	pobj	embryogenesis,in
R508	T4247	T4248	prep	For,is
R509	T4094	T4091	cc	and,starting
R510	T4249	T4247	pobj	example,For
R511	T4250	T4248	punct	", ",is
R512	T4095	T4091	conj	continuing,starting
R513	T4251	T4248	expl	there,is
R514	T4252	T4253	det	a,rate
R515	T4253	T4248	attr	rate,is
R516	T4096	T4095	prep	through,continuing
R517	T4254	T4253	amod	higher,rate
R518	T4255	T4253	compound	failure,rate
R519	T4256	T4253	prep	for,rate
R520	T4257	T4256	pobj	meiosis,for
R521	T4258	T4253	prep	in,rate
R522	T4259	T4258	pobj	females,in
R523	T4260	T4248	punct	", ",is
R524	T4097	T4096	pobj	much,through
R525	T4261	T4248	prep	with,is
R526	T4262	T4263	amod	human,rates
R527	T4263	T4261	pobj	rates,with
R528	T4098	T4097	prep	of,much
R529	T4264	T4263	compound	oocyte,rates
R530	T4265	T4263	compound	aneuploidy,rates
R531	T4266	T4267	quantmod	up,25
R532	T4099	T4100	amod	adult,life
R533	T4267	T4269	nummod	25,%
R534	T4268	T4267	quantmod	to,25
R535	T4269	T4263	npadvmod	%,rates
R536	T4100	T4098	pobj	life,of
R537	T4270	T4269	cc	versus,%
R538	T4271	T4272	quantmod	about,2
R539	T4272	T4273	nummod	2,%
R540	T4101	T4102	punct	(,reviewed
R541	T4273	T4269	conj	%,%
R542	T4274	T4273	prep	in,%
R543	T4102	T4086	parataxis	reviewed,regulated
R544	T4275	T4276	amod	human,sperm
R545	T4276	T4274	pobj	sperm,in
R546	T4103	T4102	prep	in,reviewed
R547	T4277	T4278	punct	[,3
R548	T4104	T4103	punct	[,in
R549	T4278	T4248	parataxis	3,is
R550	T4279	T4278	punct	],3
R551	T4280	T4248	punct	", ",is
R552	T4105	T4103	pobj	1,in
R553	T4281	T4248	cc	and,is
R554	T4282	T4283	nsubj	this,indicate
R555	T4283	T4248	conj	indicate,is
R556	T4106	T4102	punct	],reviewed
R557	T4284	T4283	aux	may,indicate
R558	T4285	T4286	mark	that,are
R559	T4107	T4102	punct	),reviewed
R560	T4286	T4283	ccomp	are,indicate
R561	T4287	T4288	det	the,checkpoints
R562	T4108	T4086	punct	.,regulated
R563	T4288	T4286	nsubj	checkpoints,are
R564	T4289	T4288	acl	controlling,checkpoints
R565	T4290	T4289	cc	and,controlling
R566	T4110	T4111	prep	For,are
R567	T4291	T4289	conj	monitoring,controlling
R568	T4292	T4293	det	the,events
R569	T4293	T4291	dobj	events,monitoring
R570	T4294	T4293	prep	of,events
R571	T4295	T4296	amod	meiotic,progression
R572	T4296	T4294	pobj	progression,of
R573	T4297	T4291	prep	in,monitoring
R574	T4298	T4297	pobj	males,in
R575	T4299	T4300	advmod	more,stringent
R576	T4112	T4110	pobj	example,For
R577	T4300	T4286	acomp	stringent,are
R578	T4301	T4283	punct	.,indicate
R579	T4303	T4304	advcl	Consistent,demonstrated
R580	T4305	T4303	prep	with,Consistent
R581	T4113	T4111	punct	", ",are
R582	T4306	T4307	det	this,idea
R583	T4307	T4305	pobj	idea,with
R584	T4308	T4304	punct	", ",demonstrated
R585	T4309	T4310	amod	genetic,analysis
R586	T4114	T4115	det	the,timing
R587	T4310	T4304	nsubj	analysis,demonstrated
R588	T4311	T4310	prep	of,analysis
R589	T4312	T4313	det	a,number
R590	T4313	T4311	pobj	number,of
R591	T4314	T4313	prep	of,number
R592	T4315	T4316	amod	meiotic,genes
R593	T4115	T4111	nsubj	timing,are
R594	T4316	T4314	pobj	genes,of
R595	T4317	T4316	amod	regulatory,genes
R596	T4318	T4313	prep	in,number
R597	T4116	T4115	cc	and,timing
R598	T4319	T4320	det	the,mouse
R599	T4320	T4318	pobj	mouse,in
R600	T4321	T4304	aux	has,demonstrated
R601	T4322	T4323	det	a,requirement
R602	T4117	T4115	conj	synchrony,timing
R603	T4323	T4304	dobj	requirement,demonstrated
R604	T4324	T4325	advmod	much,stronger
R605	T4325	T4323	amod	stronger,requirement
R606	T4326	T4304	prep	in,demonstrated
R607	T4118	T4115	prep	of,timing
R608	T4327	T4326	pobj	males,in
R609	T4328	T4304	prep	than,demonstrated
R610	T4329	T4328	prep	in,than
R611	T4330	T4329	pobj	females,in
R612	T4119	T4118	pobj	meiosis,of
R613	T4331	T4332	punct	[,4
R614	T4332	T4304	parataxis	4,demonstrated
R615	T4333	T4332	nummod	1,4
R616	T4120	T4121	advmod	very,different
R617	T4334	T4332	punct	",",4
R618	T4335	T4332	punct	],4
R619	T4336	T4304	punct	.,demonstrated
R620	T4121	T4111	acomp	different,are
R621	T4338	T4339	det	The,existence
R622	T4339	T4340	nsubj	existence,creates
R623	T4122	T4111	prep	in,are
R624	T4341	T4339	prep	of,existence
R625	T4342	T4343	amod	heteromorphic,chromosomes
R626	T4343	T4341	pobj	chromosomes,of
R627	T4344	T4343	compound	sex,chromosomes
R628	T4345	T4343	punct	", ",chromosomes
R629	T4346	T4347	amod	such,as
R630	T4123	T4124	det	the,sexes
R631	T4347	T4343	prep	as,chromosomes
R632	T4348	T4349	det	the,system
R633	T4349	T4347	pobj	system,as
R634	T4124	T4122	pobj	sexes,in
R635	T4350	T4351	compound	XX,XY
R636	T4351	T4349	compound	XY,system
R637	T4352	T4351	punct	/,XY
R638	T4125	T4124	nummod	two,sexes
R639	T4126	T4111	punct	.,are
R640	T4128	T4129	prep	In,initiate
R641	T4353	T4349	prep	of,system
R642	T4354	T4353	pobj	mammals,of
R643	T4355	T4340	punct	", ",creates
R644	T4130	T4128	pobj	females,In
R645	T4356	T4357	npadvmod	sex,specific
R646	T4131	T4129	punct	", ",initiate
R647	T4357	T4359	amod	specific,challenges
R648	T4358	T4357	punct	-,specific
R649	T4132	T4133	compound	germ,cells
R650	T4359	T4340	dobj	challenges,creates
R651	T4360	T4340	punct	.,creates
R652	T4133	T4129	nsubj	cells,initiate
R653	T4134	T4129	advmod	synchronously,initiate
R654	T4362	T4363	nsubj	One,is
R655	T4135	T4129	dobj	meiosis,initiate
R656	T4364	T4365	det	the,need
R657	T4365	T4363	attr	need,is
R658	T4136	T4129	prep	in,initiate
R659	T4366	T4365	prep	for,need
R660	T4367	T4366	pobj	mechanisms,for
R661	T4368	T4369	aux	to,balance
R662	T4137	T4138	det	the,embryo
R663	T4369	T4367	acl	balance,mechanisms
R664	T4370	T4369	dobj	expression,balance
R665	T4138	T4136	pobj	embryo,in
R666	T4371	T4370	prep	of,expression
R667	T4372	T4373	npadvmod	sex,linked
R668	T4373	T4375	amod	linked,genes
R669	T4139	T4129	cc	and,initiate
R670	T4374	T4373	punct	-,linked
R671	T4375	T4371	pobj	genes,of
R672	T4140	T4129	conj	arrest,initiate
R673	T4376	T4370	prep	between,expression
R674	T4377	T4378	det	the,sexes
R675	T4378	T4376	pobj	sexes,between
R676	T4459	T4452	nsubjpass	regions,associated
R677	T4379	T4370	punct	", ",expression
R678	T4380	T4381	dep	which,accomplished
R679	T4381	T4370	relcl	accomplished,expression
R680	T4382	T4381	prep	in,accomplished
R681	T4383	T4382	pobj	mammals,in
R682	T4384	T4381	auxpass	is,accomplished
R683	T4385	T4381	prep	by,accomplished
R684	T4386	T4387	compound	X,chromosome
R685	T4387	T4388	compound	chromosome,inactivation
R686	T4388	T4385	pobj	inactivation,by
R687	T4460	T4459	amod	unpaired,regions
R688	T4389	T4388	prep	in,inactivation
R689	T4390	T4389	pobj	females,in
R690	T4391	T4392	punct	[,6
R691	T4392	T4363	parataxis	6,is
R692	T4393	T4392	nummod	5,6
R693	T4461	T4459	compound	chromosome,regions
R694	T4394	T4392	punct	",",6
R695	T4395	T4392	punct	],6
R696	T4396	T4363	punct	.,is
R697	T4398	T4399	prep	In,is
R698	T4462	T4452	auxpass	are,associated
R699	T4400	T4401	amod	male,cells
R700	T4401	T4398	pobj	cells,In
R701	T4402	T4401	compound	germ,cells
R702	T4463	T4452	prep	with,associated
R703	T4403	T4399	expl	there,is
R704	T4404	T4405	det	another,consideration
R705	T4405	T4399	attr	consideration,is
R706	T4464	T4465	det	a,domain
R707	T4406	T4407	npadvmod	sex,specific
R708	T4407	T4405	amod	specific,consideration
R709	T4408	T4407	punct	-,specific
R710	T4465	T4463	pobj	domain,with
R711	T4409	T4399	prep	during,is
R712	T4410	T4409	pobj	meiosis,during
R713	T4411	T4399	punct	.,is
R714	T4466	T4465	amod	specialized,domain
R715	T4413	T4414	prep	In,limited
R716	T4467	T4465	compound	chromatin,domain
R717	T4415	T4413	pobj	prophase,In
R718	T4416	T4415	nummod	I,prophase
R719	T4417	T4415	punct	", ",prophase
R720	T4468	T4465	acl	termed,domain
R721	T4418	T4419	advmod	when,synapse
R722	T4419	T4415	relcl	synapse,prophase
R723	T4420	T4421	det	the,chromosomes
R724	T4469	T4470	det	the,body
R725	T4421	T4419	nsubj	chromosomes,synapse
R726	T4422	T4421	amod	homologous,chromosomes
R727	T4470	T4468	oprd	body,termed
R728	T4423	T4419	cc	and,synapse
R729	T4424	T4425	amod	homologous,recombination
R730	T4471	T4470	compound	XY,body
R731	T4425	T4426	nsubj	recombination,occurs
R732	T4426	T4419	conj	occurs,synapse
R733	T4427	T4414	punct	", ",limited
R734	T4428	T4429	nmod	X,chromosome
R735	T4429	T4432	compound	chromosome,pairing
R736	T4430	T4428	cc	and,X
R737	T4431	T4428	conj	Y,X
R738	T4432	T4414	nsubjpass	pairing,limited
R739	T4433	T4414	auxpass	is,limited
R740	T4472	T4470	cc	or,body
R741	T4434	T4414	prep	to,limited
R742	T4435	T4436	det	a,region
R743	T4436	T4434	pobj	region,to
R744	T4437	T4436	acl	termed,region
R745	T4473	T4474	compound	sex,body
R746	T4438	T4439	det	the,region
R747	T4439	T4437	oprd	region,termed
R748	T4440	T4439	amod	pseudoautosomal,region
R749	T4474	T4470	conj	body,body
R750	T4441	T4414	punct	", ",limited
R751	T4442	T4414	advcl	leaving,limited
R752	T4443	T4444	amod	large,portions
R753	T4475	T4452	punct	.,associated
R754	T4444	T4442	dobj	portions,leaving
R755	T4445	T4444	prep	of,portions
R756	T4446	T4447	det	each,chromosome
R757	T4477	T4478	det	The,function
R758	T4447	T4445	pobj	chromosome,of
R759	T4478	T4479	nsubj	function,is
R760	T4448	T4442	oprd	unpaired,leaving
R761	T4449	T4414	punct	.,limited
R762	T4480	T4478	prep	of,function
R763	T4451	T4452	prep	In,associated
R764	T4453	T4454	amod	eutherian,mammals
R765	T4481	T4482	det	the,body
R766	T4454	T4451	pobj	mammals,In
R767	T4455	T4453	cc	and,eutherian
R768	T4456	T4453	conj	marsupial,eutherian
R769	T4482	T4480	pobj	body,of
R770	T4457	T4452	punct	", ",associated
R771	T4458	T4459	det	these,regions
R772	T4483	T4482	compound	XY,body
R773	T4484	T4479	acomp	uncertain,is
R774	T4485	T4486	punct	[,7
R775	T4486	T4479	parataxis	7,is
R776	T4487	T4488	punct	–,11
R777	T4565	T4555	prep	in,silenced
R778	T4566	T4567	det	a,process
R779	T4488	T4486	prep	11,7
R780	T4567	T4565	pobj	process,in
R781	T4568	T4567	acl	termed,process
R782	T4489	T4486	punct	],7
R783	T4569	T4570	amod	meiotic,inactivation
R784	T4570	T4568	oprd	inactivation,termed
R785	T4571	T4570	compound	sex,inactivation
R786	T4572	T4570	compound	chromosome,inactivation
R787	T4573	T4570	punct	(,inactivation
R788	T4574	T4570	appos	MSCI,inactivation
R789	T4490	T4479	punct	", ",is
R790	T4575	T4555	punct	),silenced
R791	T4576	T4555	punct	.,silenced
R792	T4491	T4479	cc	but,is
R793	T4578	T4579	det	The,body
R794	T4579	T4581	nsubj	body,disappears
R795	T4580	T4579	compound	XY,body
R796	T4492	T4493	expl	there,is
R797	T4581	T4582	ccomp	disappears,remain
R798	T4493	T4479	conj	is,is
R799	T4583	T4581	prep	after,disappears
R800	T4584	T4583	pobj	pachynema,after
R801	T4585	T4582	punct	;,remain
R802	T4494	T4493	attr	evidence,is
R803	T4586	T4582	advmod	however,remain
R804	T4587	T4582	punct	", ",remain
R805	T4495	T4496	mark	that,is
R806	T4496	T4494	acl	is,evidence
R807	T4588	T4589	amod	many,genes
R808	T4589	T4582	nsubj	genes,remain
R809	T4497	T4496	nsubj	it,is
R810	T4590	T4591	npadvmod	sex,linked
R811	T4591	T4589	amod	linked,genes
R812	T4498	T4496	acomp	essential,is
R813	T4592	T4591	punct	-,linked
R814	T4593	T4594	advmod	transcriptionally,silent
R815	T4594	T4582	acomp	silent,remain
R816	T4499	T4498	prep	for,essential
R817	T4595	T4582	prep	into,remain
R818	T4596	T4595	pobj	spermiogenesis,into
R819	T4500	T4501	amod	male,progression
R820	T4597	T4598	punct	[,16
R821	T4598	T4582	parataxis	16,remain
R822	T4599	T4598	punct	],16
R823	T4501	T4499	pobj	progression,for
R824	T4600	T4582	punct	.,remain
R825	T4602	T4603	det	This,maintenance
R826	T4502	T4501	amod	meiotic,progression
R827	T4603	T4604	nsubjpass	maintenance,associated
R828	T4503	T4504	punct	[,12
R829	T4605	T4603	prep	of,maintenance
R830	T4606	T4605	pobj	silencing,of
R831	T4607	T4604	auxpass	is,associated
R832	T4504	T4493	parataxis	12,is
R833	T4608	T4604	prep	with,associated
R834	T4609	T4610	det	a,set
R835	T4505	T4504	punct	],12
R836	T4610	T4608	pobj	set,with
R837	T4611	T4610	amod	distinct,set
R838	T4612	T4610	prep	of,set
R839	T4613	T4614	compound	chromatin,marks
R840	T4614	T4612	pobj	marks,of
R841	T4506	T4493	punct	.,is
R842	T4615	T4616	dep	that,define
R843	T4616	T4610	relcl	define,set
R844	T4617	T4618	det	a,domain
R845	T4508	T4509	amod	Several,proteins
R846	T4618	T4616	dobj	domain,define
R847	T4619	T4618	compound	sex,domain
R848	T4509	T4510	nsubjpass	proteins,reported
R849	T4620	T4618	compound	chromatin,domain
R850	T4621	T4618	acl	termed,domain
R851	T4622	T4623	amod	postmeiotic,chromatin
R852	T4511	T4510	auxpass	are,reported
R853	T4623	T4621	oprd	chromatin,termed
R854	T4624	T4623	compound	sex,chromatin
R855	T4625	T4623	punct	(,chromatin
R856	T4512	T4513	aux	to,localize
R857	T4626	T4623	appos	PMSC,chromatin
R858	T4627	T4604	punct	),associated
R859	T4628	T4629	punct	[,17
R860	T4513	T4510	xcomp	localize,reported
R861	T4629	T4604	parataxis	17,associated
R862	T4630	T4629	nummod	16,17
R863	T4514	T4513	prep	to,localize
R864	T4631	T4629	punct	",",17
R865	T4632	T4629	punct	],17
R866	T4633	T4604	punct	.,associated
R867	T4515	T4516	det	the,body
R868	T4635	T4636	nsubjpass	Regulators,identified
R869	T4516	T4514	pobj	body,to
R870	T4637	T4635	prep	of,Regulators
R871	T4638	T4639	amod	sexual,differentiation
R872	T4517	T4516	compound	XY,body
R873	T4639	T4637	pobj	differentiation,of
R874	T4640	T4636	aux	have,identified
R875	T4518	T4510	punct	", ",reported
R876	T4641	T4636	auxpass	been,identified
R877	T4642	T4636	prep	in,identified
R878	T4643	T4644	det	a,number
R879	T4519	T4510	prep	including,reported
R880	T4644	T4642	pobj	number,in
R881	T4645	T4644	prep	of,number
R882	T4646	T4645	pobj	organisms,of
R883	T4520	T4519	pobj	BRCA1,including
R884	T4647	T4636	punct	", ",identified
R885	T4648	T4636	cc	but,identified
R886	T4521	T4520	punct	", ",BRCA1
R887	T4649	T4650	prep	in,are
R888	T4650	T4636	conj	are,identified
R889	T4651	T4649	pobj	contrast,in
R890	T4652	T4651	prep	to,contrast
R891	T4653	T4654	amod	many,processes
R892	T4654	T4652	pobj	processes,to
R893	T4522	T4520	conj	ATR,BRCA1
R894	T4655	T4654	amod	other,processes
R895	T4656	T4654	amod	developmental,processes
R896	T4523	T4522	punct	", ",ATR
R897	T4657	T4654	punct	", ",processes
R898	T4658	T4659	amod	such,as
R899	T4659	T4654	prep	as,processes
R900	T4524	T4525	det	the,H3.3
R901	T4660	T4661	amod	axial,patterning
R902	T4661	T4659	pobj	patterning,as
R903	T4662	T4661	cc	or,patterning
R904	T4525	T4522	conj	H3.3,ATR
R905	T4663	T4661	conj	development,patterning
R906	T4664	T4663	prep	of,development
R907	T4665	T4666	amod	many,parts
R908	T4526	T4525	compound	histone,H3.3
R909	T4666	T4664	pobj	parts,of
R910	T4667	T4666	compound	body,parts
R911	T4668	T4650	punct	", ",are
R912	T4527	T4525	compound	variant,H3.3
R913	T4669	T4670	det	the,mechanisms
R914	T4670	T4650	nsubj	mechanisms,are
R915	T4528	T4525	punct	", ",H3.3
R916	T4529	T4525	cc	and,H3.3
R917	T4530	T4531	amod	modified,histones
R918	T4671	T4670	amod	molecular,mechanisms
R919	T4531	T4525	conj	histones,H3.3
R920	T4672	T4673	dep	that,regulate
R921	T4673	T4670	relcl	regulate,mechanisms
R922	T4674	T4675	amod	sexual,differentiation
R923	T4532	T4533	amod	such,as
R924	T4675	T4673	dobj	differentiation,regulate
R925	T4676	T4677	advmod	highly,variable
R926	T4533	T4531	prep	as,histones
R927	T4677	T4650	acomp	variable,are
R928	T4678	T4650	prep	between,are
R929	T4679	T4678	pobj	phyla,between
R930	T4534	T4535	amod	ubiquitinated,H2A
R931	T4680	T4650	punct	.,are
R932	T4535	T4533	pobj	H2A,as
R933	T4682	T4683	det	A,exception
R934	T4683	T4685	nsubj	exception,involves
R935	T4684	T4683	amod	notable,exception
R936	T4536	T4535	punct	(,H2A
R937	T4686	T4685	dobj	genes,involves
R938	T4537	T4538	compound	Ub,H2A
R939	T4687	T4686	acl	related,genes
R940	T4688	T4687	prep	to,related
R941	T4689	T4688	pobj	doublesex,to
R942	T4538	T4535	appos	H2A,H2A
R943	T4690	T4689	punct	(,doublesex
R944	T4691	T4689	appos	dsx,doublesex
R945	T4692	T4689	punct	),doublesex
R946	T4693	T4689	prep	of,doublesex
R947	T4694	T4693	pobj	Drosophila,of
R948	T4695	T4686	punct	", ",genes
R949	T4539	T4538	punct	-,H2A
R950	T4696	T4697	dep	which,share
R951	T4697	T4686	relcl	share,genes
R952	T4540	T4535	punct	),H2A
R953	T4698	T4699	det	a,motif
R954	T4541	T4535	cc	and,H2A
R955	T4699	T4697	dobj	motif,share
R956	T4700	T4701	nmod	Doublesex,MAB
R957	T4542	T4543	amod	phosphorylated,H2AX
R958	T4701	T4699	nmod	MAB,motif
R959	T4702	T4701	punct	/,MAB
R960	T4543	T4535	conj	H2AX,H2A
R961	T4703	T4701	punct	-,MAB
R962	T4704	T4701	nummod	3,MAB
R963	T4705	T4699	nmod	DNA,motif
R964	T4544	T4543	punct	(,H2AX
R965	T4706	T4705	punct	-,DNA
R966	T4707	T4705	amod	binding,DNA
R967	T4708	T4699	acl	called,motif
R968	T4545	T4543	appos	γH2AX,H2AX
R969	T4709	T4710	det	the,domain
R970	T4710	T4708	oprd	domain,called
R971	T4546	T4510	punct	),reported
R972	T4711	T4710	compound	DM,domain
R973	T4712	T4713	punct	[,19
R974	T4547	T4548	punct	[,12
R975	T4713	T4685	parataxis	19,involves
R976	T4714	T4713	nummod	18,19
R977	T4715	T4713	punct	",",19
R978	T4548	T4510	parataxis	12,reported
R979	T4716	T4713	punct	],19
R980	T4717	T4685	punct	.,involves
R981	T4549	T4550	punct	–,15
R982	T4719	T4720	nmod	DM,genes
R983	T4720	T4724	nsubjpass	genes,shown
R984	T4550	T4548	prep	15,12
R985	T4721	T4722	npadvmod	domain,encoding
R986	T4722	T4720	amod	encoding,genes
R987	T4551	T4548	punct	],12
R988	T4723	T4722	punct	–,encoding
R989	T4725	T4724	aux	have,shown
R990	T4552	T4510	punct	.,reported
R991	T4726	T4724	auxpass	been,shown
R992	T4727	T4728	aux	to,regulate
R993	T4728	T4724	xcomp	regulate,shown
R994	T4554	T4555	prep	In,silenced
R995	T4729	T4730	amod	various,aspects
R996	T4730	T4728	dobj	aspects,regulate
R997	T4731	T4730	prep	of,aspects
R998	T4732	T4733	amod	sexual,differentiation
R999	T4733	T4731	pobj	differentiation,of
R1000	T4734	T4728	prep	in,regulate
R1001	T4556	T4557	det	the,body
R1002	T4735	T4734	pobj	insects,in
R1003	T4736	T4735	punct	", ",insects
R1004	T4737	T4735	conj	nematodes,insects
R1005	T4557	T4554	pobj	body,In
R1006	T4738	T4737	punct	", ",nematodes
R1007	T4739	T4737	cc	and,nematodes
R1008	T4740	T4737	conj	mammals,nematodes
R1009	T4558	T4557	compound	XY,body
R1010	T4741	T4742	punct	[,20
R1011	T4742	T4724	parataxis	20,shown
R1012	T4743	T4742	punct	],20
R1013	T4559	T4555	punct	", ",silenced
R1014	T4744	T4724	punct	.,shown
R1015	T4560	T4561	det	the,chromosomes
R1016	T4746	T4747	det	The,gene
R1017	T4561	T4555	nsubjpass	chromosomes,silenced
R1018	T4747	T4751	nsubjpass	gene,shown
R1019	T4562	T4561	compound	sex,chromosomes
R1020	T4748	T4747	nmod	mab,gene
R1021	T4749	T4748	punct	-,mab
R1022	T4750	T4748	nummod	3,mab
R1023	T4563	T4555	auxpass	are,silenced
R1024	T4752	T4747	prep	of,gene
R1025	T4564	T4555	advmod	transcriptionally,silenced
R1026	T4753	T4754	compound	Caenorhabditis,elegans
R1027	T4754	T4752	pobj	elegans,of
R1028	T4755	T4751	aux	has,shown
R1029	T4777	T4751	advcl	suggesting,shown
R1030	T4756	T4751	auxpass	been,shown
R1031	T4757	T4758	aux	to,function
R1032	T4758	T4751	xcomp	function,shown
R1033	T4759	T4758	advmod	analogously,function
R1034	T4778	T4779	mark	that,stem
R1035	T4760	T4759	prep	to,analogously
R1036	T4761	T4760	pobj	DSX,to
R1037	T4762	T4758	prep	in,function
R1038	T4779	T4777	ccomp	stem,suggesting
R1039	T4763	T4764	amod	several,respects
R1040	T4764	T4762	pobj	respects,in
R1041	T4765	T4751	cc	and,shown
R1042	T4780	T4781	det	the,similarity
R1043	T4766	T4767	aux	can,replaced
R1044	T4767	T4751	conj	replaced,shown
R1045	T4781	T4779	nsubj	similarity,stem
R1046	T4768	T4767	auxpass	be,replaced
R1047	T4769	T4767	advmod	functionally,replaced
R1048	T4770	T4767	agent	by,replaced
R1049	T4771	T4772	det	the,isoform
R1050	T4772	T4770	pobj	isoform,by
R1051	T4773	T4772	amod	male,isoform
R1052	T4774	T4772	prep	of,isoform
R1053	T4782	T4781	prep	in,similarity
R1054	T4775	T4774	pobj	DSX,of
R1055	T4776	T4751	punct	", ",shown
R1056	T4783	T4784	det	the,sequence
R1057	T4784	T4782	pobj	sequence,in
R1058	T4785	T4784	prep	of,sequence
R1059	T4786	T4787	det	these,genes
R1060	T4883	T4882	punct	", ",birds
R1061	T4787	T4785	pobj	genes,of
R1062	T4884	T4882	conj	fish,birds
R1063	T4788	T4779	aux	may,stem
R1064	T4885	T4884	punct	", ",fish
R1065	T4789	T4779	prep	from,stem
R1066	T4886	T4884	cc	and,fish
R1067	T4887	T4884	conj	reptiles,fish
R1068	T4888	T4862	punct	", ",expressed
R1069	T4889	T4862	cc	and,expressed
R1070	T4890	T4891	det	a,gene
R1071	T4790	T4789	pobj	conservation,from
R1072	T4891	T4895	nsubj	gene,functions
R1073	T4892	T4893	advmod	recently,duplicated
R1074	T4893	T4891	amod	duplicated,gene
R1075	T4791	T4790	prep	of,conservation
R1076	T4894	T4891	compound	Dmrt1,gene
R1077	T4895	T4862	conj	functions,expressed
R1078	T4896	T4895	prep	as,functions
R1079	T4792	T4793	det	an,regulator
R1080	T4897	T4898	det	the,gene
R1081	T4898	T4896	pobj	gene,as
R1082	T4899	T4900	npadvmod	Y,linked
R1083	T4793	T4791	pobj	regulator,of
R1084	T4900	T4898	amod	linked,gene
R1085	T4901	T4900	punct	-,linked
R1086	T4794	T4793	amod	ancestral,regulator
R1087	T4902	T4903	npadvmod	testis,determining
R1088	T4903	T4898	amod	determining,gene
R1089	T4904	T4903	punct	-,determining
R1090	T4795	T4796	nmod	DM,domain
R1091	T4905	T4895	prep	in,functions
R1092	T4906	T4907	det	the,fish
R1093	T4907	T4905	pobj	fish,in
R1094	T4796	T4793	nmod	domain,regulator
R1095	T4908	T4907	compound	Medaka,fish
R1096	T4909	T4910	punct	[,25
R1097	T4910	T4895	parataxis	25,functions
R1098	T4797	T4793	amod	sexual,regulator
R1099	T4911	T4912	punct	–,29
R1100	T4912	T4910	prep	29,25
R1101	T4913	T4910	punct	],25
R1102	T4914	T4895	punct	.,functions
R1103	T4916	T4917	amod	Human,DMRT1
R1104	T4798	T4799	punct	[,22
R1105	T4917	T4918	nsubj	DMRT1,maps
R1106	T4919	T4918	prep	to,maps
R1107	T4920	T4921	det	an,locus
R1108	T4799	T4751	parataxis	22,shown
R1109	T4921	T4919	pobj	locus,to
R1110	T4922	T4921	amod	autosomal,locus
R1111	T4923	T4921	punct	", ",locus
R1112	T4800	T4799	nummod	18,22
R1113	T4924	T4925	dep	which,associated
R1114	T4925	T4921	relcl	associated,locus
R1115	T4801	T4799	punct	",",22
R1116	T4926	T4925	punct	", ",associated
R1117	T4927	T4928	advmod	when,hemizygous
R1118	T4928	T4925	advcl	hemizygous,associated
R1119	T4802	T4799	nummod	21,22
R1120	T4929	T4925	punct	", ",associated
R1121	T4930	T4925	auxpass	is,associated
R1122	T4803	T4799	punct	",",22
R1123	T4931	T4925	prep	with,associated
R1124	T4932	T4933	amod	defective,development
R1125	T4933	T4931	pobj	development,with
R1126	T4934	T4933	amod	testicular,development
R1127	T4804	T4799	punct	],22
R1128	T4935	T4933	cc	and,development
R1129	T4936	T4937	amod	consequent,feminization
R1130	T4805	T4751	punct	.,shown
R1131	T4937	T4933	conj	feminization,development
R1132	T4938	T4937	compound	XY,feminization
R1133	T4939	T4940	punct	[,30
R1134	T4807	T4808	nsubj	Vertebrates,have
R1135	T4940	T4918	parataxis	30,maps
R1136	T4941	T4940	punct	],30
R1137	T4942	T4918	punct	.,maps
R1138	T4809	T4808	advmod	also,have
R1139	T4944	T4945	advmod	Similarly,have
R1140	T4946	T4945	punct	", ",have
R1141	T4947	T4945	nsubj	mice,have
R1142	T4810	T4811	compound	DM,domain
R1143	T4948	T4947	amod	homozygous,mice
R1144	T4949	T4948	prep	for,homozygous
R1145	T4950	T4951	det	a,mutation
R1146	T4811	T4812	compound	domain,genes
R1147	T4951	T4949	pobj	mutation,for
R1148	T4952	T4951	amod	null,mutation
R1149	T4953	T4951	prep	in,mutation
R1150	T4812	T4808	dobj	genes,have
R1151	T4954	T4953	pobj	Dmrt1,in
R1152	T4955	T4956	amod	severe,defects
R1153	T4813	T4808	punct	", ",have
R1154	T4956	T4945	dobj	defects,have
R1155	T4957	T4956	prep	in,defects
R1156	T4958	T4959	compound	testis,differentiation
R1157	T4959	T4957	pobj	differentiation,in
R1158	T4814	T4808	cc	and,have
R1159	T4960	T4956	acl	involving,defects
R1160	T4961	T4962	preconj	both,cells
R1161	T4815	T4816	nsubj	analysis,shown
R1162	T4962	T4960	dobj	cells,involving
R1163	T4963	T4962	compound	germ,cells
R1164	T4964	T4962	cc	and,cells
R1165	T4816	T4808	conj	shown,have
R1166	T4965	T4966	compound	Sertoli,cells
R1167	T4966	T4962	conj	cells,cells
R1168	T4817	T4815	prep	to,analysis
R1169	T4967	T4968	punct	[,31
R1170	T4968	T4945	parataxis	31,have
R1171	T4818	T4817	pobj	date,to
R1172	T4969	T4968	punct	],31
R1173	T4970	T4945	punct	.,have
R1174	T4819	T4816	punct	", ",shown
R1175	T4972	T4973	amod	Female,mice
R1176	T4973	T4974	nsubj	mice,have
R1177	T4820	T4821	mark	although,limited
R1178	T4975	T4973	relcl	mutant,mice
R1179	T4821	T4816	advcl	limited,shown
R1180	T4822	T4816	punct	", ",shown
R1181	T4976	T4975	prep	in,mutant
R1182	T4823	T4816	aux	has,shown
R1183	T4977	T4976	pobj	Dmrt4,in
R1184	T4978	T4979	amod	polyovular,follicles
R1185	T4979	T4974	dobj	follicles,have
R1186	T4824	T4825	mark	that,control
R1187	T4980	T4974	punct	", ",have
R1188	T4981	T4974	advcl	indicating,have
R1189	T4825	T4816	ccomp	control,shown
R1190	T4982	T4983	mark	that,plays
R1191	T4983	T4981	ccomp	plays,indicating
R1192	T4984	T4985	det	this,gene
R1193	T4826	T4827	det	these,genes
R1194	T4985	T4983	nsubj	gene,plays
R1195	T4986	T4983	advmod	also,plays
R1196	T4827	T4825	nsubj	genes,control
R1197	T4987	T4988	det	a,role
R1198	T4988	T4983	dobj	role,plays
R1199	T4828	T4825	advmod	also,control
R1200	T4829	T4830	amod	sexual,differentiation
R1201	T4989	T4983	prep	in,plays
R1202	T4830	T4825	dobj	differentiation,control
R1203	T4990	T4991	amod	gonadal,development
R1204	T4991	T4989	pobj	development,in
R1205	T4831	T4816	punct	.,shown
R1206	T4992	T4993	punct	[,32
R1207	T4993	T4974	parataxis	32,have
R1208	T4994	T4993	punct	],32
R1209	T4995	T4974	punct	.,have
R1210	T4997	T4998	nsubj	It,appears
R1211	T4833	T4834	nsubj	Mammals,have
R1212	T4999	T4998	prep	from,appears
R1213	T5000	T5001	det	these,studies
R1214	T5001	T4999	pobj	studies,from
R1215	T4835	T4836	nummod	seven,genes
R1216	T5002	T5003	mark	that,is
R1217	T5003	T4998	ccomp	is,appears
R1218	T5004	T5005	det	the,involvement
R1219	T4836	T4834	dobj	genes,have
R1220	T5005	T5003	nsubj	involvement,is
R1221	T5006	T5005	prep	of,involvement
R1222	T5007	T5008	compound	DM,domain
R1223	T4837	T4838	compound	DM,domain
R1224	T5008	T5009	compound	domain,genes
R1225	T5009	T5006	pobj	genes,of
R1226	T5010	T5005	prep	in,involvement
R1227	T4838	T4836	compound	domain,genes
R1228	T5011	T5012	amod	sexual,differentiation
R1229	T5012	T5010	pobj	differentiation,in
R1230	T4839	T4840	punct	(,genes
R1231	T5013	T5003	acomp	ancient,is
R1232	T5014	T5013	cc	and,ancient
R1233	T5015	T5013	conj	conserved,ancient
R1234	T4840	T4836	parataxis	genes,genes
R1235	T5016	T4998	punct	.,appears
R1236	T5018	T5019	advmod	However,is
R1237	T4841	T4840	compound	Dmrt,genes
R1238	T5019	T5025	ccomp	is,required
R1239	T5020	T5019	punct	", ",is
R1240	T4842	T4840	punct	),genes
R1241	T5021	T5022	compound	vertebrate,function
R1242	T5022	T5019	nsubj	function,is
R1243	T5023	T5022	compound	Dmrt,function
R1244	T4843	T4836	punct	", ",genes
R1245	T5024	T5022	compound	gene,function
R1246	T5026	T5019	neg	not,is
R1247	T4844	T4845	dep	several,exhibit
R1248	T5027	T5019	acomp	limited,is
R1249	T5028	T5027	prep	to,limited
R1250	T4845	T4836	relcl	exhibit,genes
R1251	T5029	T5030	amod	sexual,differentiation
R1252	T5030	T5028	pobj	differentiation,to
R1253	T5031	T5025	punct	: ,required
R1254	T5032	T5025	nsubjpass	Dmrt2,required
R1255	T4846	T4844	prep	of,several
R1256	T5033	T5025	auxpass	is,required
R1257	T5034	T5025	prep	in,required
R1258	T4847	T4846	pobj	which,of
R1259	T5035	T5036	det	both,sexes
R1260	T5036	T5034	pobj	sexes,in
R1261	T5037	T5025	prep	for,required
R1262	T5038	T5037	pobj	segmentation,for
R1263	T5039	T5038	prep	in,segmentation
R1264	T5040	T5039	pobj	mice,in
R1265	T4848	T4849	advmod	sexually,dimorphic
R1266	T5041	T5040	cc	and,mice
R1267	T5042	T5040	conj	fish,mice
R1268	T5043	T5044	punct	[,33
R1269	T5044	T5025	parataxis	33,required
R1270	T4849	T4850	amod	dimorphic,expression
R1271	T5045	T5046	punct	–,35
R1272	T4850	T4845	dobj	expression,exhibit
R1273	T5046	T5044	prep	35,33
R1274	T5047	T5044	punct	],33
R1275	T4851	T4850	compound	mRNA,expression
R1276	T5048	T5025	punct	.,required
R1277	T5050	T5051	advmod	Here,investigated
R1278	T4852	T4853	punct	[,24
R1279	T5052	T5051	punct	", ",investigated
R1280	T5053	T5051	nsubj	we,investigated
R1281	T4853	T4834	parataxis	24,have
R1282	T5054	T5051	aux	have,investigated
R1283	T5055	T5056	det	the,expression
R1284	T5056	T5051	dobj	expression,investigated
R1285	T4854	T4853	nummod	23,24
R1286	T5057	T5056	cc	and,expression
R1287	T5058	T5056	conj	function,expression
R1288	T4855	T4853	punct	",",24
R1289	T5059	T5056	prep	of,expression
R1290	T5060	T5061	det	the,gene
R1291	T5061	T5059	pobj	gene,of
R1292	T4856	T4853	punct	],24
R1293	T5062	T5061	compound	Dmrt7,gene
R1294	T5063	T5056	prep	in,expression
R1295	T4857	T4834	punct	.,have
R1296	T5064	T5065	det	the,mouse
R1297	T5065	T5063	pobj	mouse,in
R1298	T5066	T5051	punct	.,investigated
R1299	T4859	T4860	det	The,studied
R1300	T5068	T5069	nsubjpass	Dmrt7,expressed
R1301	T4860	T4862	nsubjpass	studied,expressed
R1302	T5070	T5069	auxpass	is,expressed
R1303	T5071	T5069	advmod	only,expressed
R1304	T5072	T5069	prep	in,expressed
R1305	T4861	T4860	advmod	best,studied
R1306	T5073	T5074	det	the,gonad
R1307	T5074	T5072	pobj	gonad,in
R1308	T4863	T4860	prep	of,studied
R1309	T5075	T5069	punct	", ",expressed
R1310	T5076	T5069	cc	and,expressed
R1311	T5077	T5069	punct	", ",expressed
R1312	T5078	T5079	prep	unlike,appears
R1313	T4864	T4865	det	these,genes
R1314	T5079	T5069	conj	appears,expressed
R1315	T5080	T5081	det	the,genes
R1316	T5081	T5078	pobj	genes,unlike
R1317	T5082	T5081	amod	other,genes
R1318	T5083	T5081	compound	Dmrt,genes
R1319	T4865	T4863	pobj	genes,of
R1320	T5084	T5079	punct	", ",appears
R1321	T5085	T5086	aux	to,be
R1322	T5086	T5079	xcomp	be,appears
R1323	T4866	T4860	punct	", ",studied
R1324	T5087	T5086	acomp	present,be
R1325	T5088	T5089	advmod	exclusively,in
R1326	T4867	T4860	appos	Dmrt1,studied
R1327	T5089	T5086	prep	in,be
R1328	T5090	T5089	pobj	mammals,in
R1329	T5091	T5089	cc	and,in
R1330	T4868	T4862	punct	", ",expressed
R1331	T5092	T5091	neg	not,and
R1332	T5093	T5089	conj	in,in
R1333	T4869	T4862	auxpass	is,expressed
R1334	T5094	T5095	amod	nonmammalian,vertebrates
R1335	T4870	T4862	prep	in,expressed
R1336	T4871	T4872	det	the,ridges
R1337	T5095	T5093	pobj	vertebrates,in
R1338	T5096	T5097	punct	[,36
R1339	T4872	T4870	pobj	ridges,in
R1340	T5097	T5079	parataxis	36,appears
R1341	T5098	T5097	nummod	23,36
R1342	T5099	T5097	punct	",",36
R1343	T4873	T4872	amod	differentiating,ridges
R1344	T5100	T5097	punct	],36
R1345	T5101	T5069	punct	.,expressed
R1346	T4874	T4872	amod	male,ridges
R1347	T5103	T5104	nsubj	We,find
R1348	T4875	T4872	amod	genital,ridges
R1349	T5105	T5106	mark	that,expressed
R1350	T5106	T5104	ccomp	expressed,find
R1351	T4876	T4872	cc	and,ridges
R1352	T5107	T5108	compound	DMRT7,protein
R1353	T5108	T5106	nsubjpass	protein,expressed
R1354	T5109	T5106	auxpass	is,expressed
R1355	T4877	T4878	amod	adult,testis
R1356	T5110	T5106	advmod	only,expressed
R1357	T5111	T5106	prep	in,expressed
R1358	T5112	T5113	compound	germ,cells
R1359	T4878	T4872	conj	testis,ridges
R1360	T5113	T5111	pobj	cells,in
R1361	T5114	T5106	cc	and,expressed
R1362	T5115	T5116	auxpass	is,localized
R1363	T4879	T4872	prep	of,ridges
R1364	T5116	T5106	conj	localized,expressed
R1365	T5117	T5116	advmod	selectively,localized
R1366	T5118	T5116	prep	to,localized
R1367	T5119	T5120	det	the,body
R1368	T5120	T5118	pobj	body,to
R1369	T5121	T5120	compound	XY,body
R1370	T4880	T4879	pobj	mammals,of
R1371	T5122	T5120	prep	of,body
R1372	T5123	T5124	amod	male,cells
R1373	T5124	T5122	pobj	cells,of
R1374	T4881	T4880	punct	", ",mammals
R1375	T5125	T5124	compound	pachytene,cells
R1376	T5126	T5124	compound	germ,cells
R1377	T4882	T4880	conj	birds,mammals
R1378	T5127	T5104	punct	.,find
R1379	T5129	T5130	aux	To,test
R1380	T5201	T5196	prep	in,plays
R1381	T5130	T5131	advcl	test,generated
R1382	T5132	T5133	poss	its,function
R1383	T5133	T5130	dobj	function,test
R1384	T5202	T5203	det	a,transition
R1385	T5203	T5201	pobj	transition,in
R1386	T5134	T5131	punct	", ",generated
R1387	T5135	T5131	nsubj	we,generated
R1388	T5204	T5205	amod	male,specific
R1389	T5136	T5137	det	a,mutation
R1390	T5137	T5131	dobj	mutation,generated
R1391	T5205	T5203	amod	specific,transition
R1392	T5206	T5205	punct	-,specific
R1393	T5138	T5137	amod	conditional,mutation
R1394	T5139	T5137	amod	null,mutation
R1395	T5207	T5203	compound	chromatin,transition
R1396	T5140	T5137	prep	of,mutation
R1397	T5141	T5140	pobj	Dmrt7,of
R1398	T5208	T5203	prep	between,transition
R1399	T5142	T5131	prep	in,generated
R1400	T5143	T5144	det	the,mouse
R1401	T5144	T5142	pobj	mouse,in
R1402	T5209	T5208	pobj	pachynema,between
R1403	T5145	T5131	punct	.,generated
R1404	T5210	T5209	cc	and,pachynema
R1405	T5147	T5148	nsubj	We,find
R1406	T5211	T5209	conj	diplonema,pachynema
R1407	T5149	T5150	mark	that,required
R1408	T5150	T5148	ccomp	required,find
R1409	T5151	T5150	nsubjpass	Dmrt7,required
R1410	T5212	T5196	prep	during,plays
R1411	T5152	T5150	auxpass	is,required
R1412	T5153	T5150	prep	in,required
R1413	T5154	T5153	pobj	males,in
R1414	T5213	T5214	amod	meiotic,prophase
R1415	T5155	T5150	prep	for,required
R1416	T5156	T5155	pobj	progression,for
R1417	T5157	T5156	prep	beyond,progression
R1418	T5214	T5212	pobj	prophase,during
R1419	T5158	T5159	det	the,stage
R1420	T5159	T5157	pobj	stage,beyond
R1421	T5160	T5159	compound	pachytene,stage
R1422	T5161	T5159	prep	of,stage
R1423	T5162	T5163	amod	meiotic,prophase
R1424	T5163	T5161	pobj	prophase,of
R1425	T5215	T5189	punct	.,suggest
R1426	T5164	T5150	cc	but,required
R1427	T5165	T5166	auxpass	is,required
R1428	T5166	T5150	conj	required,required
R1429	T5167	T5166	neg	not,required
R1430	T5168	T5166	prep	in,required
R1431	T5169	T5168	pobj	females,in
R1432	T5170	T5148	punct	.,find
R1433	T5172	T5173	prep	In,observed
R1434	T5174	T5175	amod	rare,cells
R1435	T5175	T5172	pobj	cells,In
R1436	T5176	T5175	compound	mutant,cells
R1437	T5177	T5178	dep	that,survive
R1438	T5178	T5175	relcl	survive,cells
R1439	T5179	T5178	prep	to,survive
R1440	T5180	T5179	pobj	diplonema,to
R1441	T5181	T5173	punct	", ",observed
R1442	T5182	T5173	nsubj	we,observed
R1443	T5183	T5184	compound	sex,chromatin
R1444	T5184	T5185	compound	chromatin,abnormalities
R1445	T5185	T5173	dobj	abnormalities,observed
R1446	T5186	T5173	punct	.,observed
R1447	T5188	T5189	prep	Based,suggest
R1448	T5190	T5188	prep	on,Based
R1449	T5191	T5192	det	these,observations
R1450	T5192	T5190	pobj	observations,on
R1451	T5193	T5189	punct	", ",suggest
R1452	T5194	T5189	nsubj	we,suggest
R1453	T5195	T5196	mark	that,plays
R1454	T5196	T5189	ccomp	plays,suggest
R1455	T5197	T5196	nsubj	Dmrt7,plays
R1456	T5198	T5199	det	a,role
R1457	T5199	T5196	dobj	role,plays
R1458	T5200	T5199	amod	critical,role
R1459	T6760	T6759	prep	of,Expression
R1460	T6761	T6762	compound	DMRT7,Proteins
R1461	T6762	T6760	pobj	Proteins,of
R1462	T6763	T6759	prep	in,Expression
R1463	T6764	T6763	pobj	Testis,in
R1464	T6766	T6767	poss	Our,analysis
R1465	T6767	T6771	nsubj	analysis,suggested
R1466	T6768	T6767	amod	previous,analysis
R1467	T6769	T6770	compound	mRNA,expression
R1468	T6770	T6767	compound	expression,analysis
R1469	T6772	T6773	det	a,function
R1470	T6773	T6771	dobj	function,suggested
R1471	T6774	T6773	amod	possible,function
R1472	T6775	T6773	amod	meiotic,function
R1473	T6776	T6773	prep	for,function
R1474	T6777	T6776	pobj	Dmrt7,for
R1475	T6778	T6771	punct	", ",suggested
R1476	T6779	T6771	prep	based,suggested
R1477	T6780	T6779	prep	on,based
R1478	T6781	T6782	det	the,expression
R1479	T6782	T6780	pobj	expression,on
R1480	T6783	T6782	prep	of,expression
R1481	T6784	T6785	compound	Dmrt7,mRNA
R1482	T6785	T6783	pobj	mRNA,of
R1483	T6786	T6782	prep	in,expression
R1484	T6787	T6788	det	the,gonads
R1485	T6788	T6786	pobj	gonads,in
R1486	T6789	T6788	amod	fetal,gonads
R1487	T6790	T6788	prep	of,gonads
R1488	T6791	T6792	det	the,sexes
R1489	T6792	T6790	pobj	sexes,of
R1490	T6793	T6792	nummod	two,sexes
R1491	T6794	T6795	punct	[,23
R1492	T6795	T6771	parataxis	23,suggested
R1493	T6796	T6795	punct	],23
R1494	T6797	T6771	punct	.,suggested
R1495	T6799	T6800	prep	In,detected
R1496	T6801	T6802	det	the,ovary
R1497	T6802	T6799	pobj	ovary,In
R1498	T6803	T6802	amod	fetal,ovary
R1499	T6804	T6800	punct	", ",detected
R1500	T6805	T6806	compound	Dmrt7,mRNA
R1501	T6806	T6800	nsubjpass	mRNA,detected
R1502	T6807	T6800	auxpass	was,detected
R1503	T6808	T6800	advmod	primarily,detected
R1504	T6809	T6800	prep	from,detected
R1505	T6810	T6809	pobj	E13.5,from
R1506	T6811	T6809	prep	to,from
R1507	T6812	T6811	pobj	E15.5,to
R1508	T6813	T6800	punct	", ",detected
R1509	T6814	T6815	det	the,time
R1510	T6815	T6800	npadvmod	time,detected
R1511	T6816	T6817	prep	during,progresses
R1512	T6817	T6815	relcl	progresses,time
R1513	T6818	T6816	pobj	which,during
R1514	T6819	T6817	nsubj	meiosis,progresses
R1515	T6820	T6817	prep	from,progresses
R1516	T6821	T6822	amod	pre-meiotic,replication
R1517	T6822	T6820	pobj	replication,from
R1518	T6823	T6820	prep	to,from
R1519	T6824	T6825	det	the,stage
R1520	T6825	T6823	pobj	stage,to
R1521	T6826	T6825	compound	pachytene,stage
R1522	T6827	T6828	punct	[,4
R1523	T6828	T6800	parataxis	4,detected
R1524	T6829	T6828	punct	],4
R1525	T6830	T6800	punct	", ",detected
R1526	T6831	T6832	mark	whereas,was
R1527	T6832	T6800	advcl	was,detected
R1528	T6833	T6834	compound	Dmrt7,expression
R1529	T6834	T6832	nsubj	expression,was
R1530	T6835	T6834	prep	in,expression
R1531	T6836	T6837	det	the,testis
R1532	T6837	T6835	pobj	testis,in
R1533	T6838	T6837	amod	non-meiotic,testis
R1534	T6839	T6837	amod	fetal,testis
R1535	T6840	T6841	advmod	very,low
R1536	T6841	T6832	acomp	low,was
R1537	T6842	T6800	punct	.,detected
R1538	T6844	T6845	mark	Because,examine
R1539	T6845	T6851	advcl	examine,performed
R1540	T6846	T6847	det	this,work
R1541	T6847	T6845	nsubj	work,examine
R1542	T6848	T6847	amod	earlier,work
R1543	T6849	T6845	aux	did,examine
R1544	T6850	T6845	neg	not,examine
R1545	T6852	T6853	amod	adult,expression
R1546	T6853	T6845	dobj	expression,examine
R1547	T6854	T6853	compound	Dmrt7,expression
R1548	T6855	T6851	punct	", ",performed
R1549	T6856	T6851	nsubj	we,performed
R1550	T6857	T6851	advmod	first,performed
R1551	T6858	T6859	amod	reverse,transcriptase
R1552	T6859	T6860	nmod	transcriptase,PCR
R1553	T6860	T6851	dobj	PCR,performed
R1554	T6861	T6859	punct	(,transcriptase
R1555	T6862	T6859	appos	RT,transcriptase
R1556	T6863	T6860	punct	),PCR
R1557	T6864	T6860	punct	-,PCR
R1558	T6865	T6860	prep	on,PCR
R1559	T6866	T6865	pobj	mRNA,on
R1560	T6867	T6866	prep	from,mRNA
R1561	T6868	T6869	nummod	ten,organs
R1562	T6869	T6867	pobj	organs,from
R1563	T6870	T6869	amod	adult,organs
R1564	T6871	T6851	cc	and,performed
R1565	T6872	T6851	conj	detected,performed
R1566	T6873	T6874	amod	strong,expression
R1567	T6874	T6872	dobj	expression,detected
R1568	T6875	T6874	compound	Dmrt7,expression
R1569	T6876	T6874	compound	mRNA,expression
R1570	T6877	T6874	prep	in,expression
R1571	T6878	T6879	det	the,testis
R1572	T6879	T6877	pobj	testis,in
R1573	T6880	T6874	cc	and,expression
R1574	T6881	T6882	det	a,trace
R1575	T6882	T6874	conj	trace,expression
R1576	T6883	T6882	prep	of,trace
R1577	T6884	T6883	pobj	expression,of
R1578	T6885	T6882	prep	in,trace
R1579	T6886	T6885	pobj	heart,in
R1580	T6887	T6885	punct	", ",in
R1581	T6888	T6885	cc	but,in
R1582	T6889	T6888	neg	not,but
R1583	T6890	T6885	conj	in,in
R1584	T6891	T6892	det	any,tissue
R1585	T6892	T6890	pobj	tissue,in
R1586	T6893	T6892	amod	other,tissue
R1587	T6894	T6892	acl	tested,tissue
R1588	T6895	T6896	punct	(,1A
R1589	T6896	T6872	parataxis	1A,detected
R1590	T6897	T6896	compound	Figure,1A
R1591	T6898	T6896	punct	),1A
R1592	T6899	T6851	punct	.,performed
R1593	T6901	T6902	nsubj	We,examined
R1594	T6903	T6904	det	the,timing
R1595	T6904	T6902	dobj	timing,examined
R1596	T6905	T6904	prep	of,timing
R1597	T6906	T6907	compound	Dmrt7,expression
R1598	T6907	T6905	pobj	expression,of
R1599	T6908	T6907	compound	mRNA,expression
R1600	T6909	T6904	prep	during,timing
R1601	T6910	T6911	amod	postnatal,development
R1602	T6911	T6909	pobj	development,during
R1603	T6912	T6911	compound	testis,development
R1604	T6913	T6902	cc	and,examined
R1605	T6914	T6902	conj	detected,examined
R1606	T6915	T6916	amod	strong,expression
R1607	T6916	T6914	dobj	expression,detected
R1608	T6917	T6916	acl	beginning,expression
R1609	T6918	T6917	prep	at,beginning
R1610	T6919	T6920	nummod	2,wk
R1611	T6920	T6918	pobj	wk,at
R1612	T6921	T6916	punct	", ",expression
R1613	T6922	T6923	dep	which,coincides
R1614	T6923	T6916	relcl	coincides,expression
R1615	T6924	T6923	advmod	roughly,coincides
R1616	T6925	T6923	prep	with,coincides
R1617	T6926	T6927	det	the,onset
R1618	T6927	T6925	pobj	onset,with
R1619	T6928	T6927	prep	of,onset
R1620	T6929	T6930	det	the,stage
R1621	T6930	T6928	pobj	stage,of
R1622	T6931	T6930	compound	pachytene,stage
R1623	T6932	T6927	prep	during,onset
R1625	T6934	T6932	pobj	wave,during
R1626	T6935	T6934	amod	first,wave
R1627	T6936	T6934	amod	synchronous,wave
R1628	T6937	T6934	prep	of,wave
R1629	T6938	T6937	pobj	spermatogenesis,of
R1630	T6939	T6940	punct	(,1B
R1631	T6940	T6923	parataxis	1B,coincides
R1632	T6941	T6940	compound	Figure,1B
R1633	T6942	T6940	punct	),1B
R1634	T6943	T6944	punct	[,37
R1635	T6944	T6914	parataxis	37,detected
R1636	T6945	T6944	punct	],37
R1637	T6946	T6902	punct	.,examined
R1638	T6949	T6950	aux	To,investigate
R1639	T6950	T6951	advcl	investigate,generated
R1640	T6952	T6953	compound	DMRT7,expression
R1641	T6953	T6950	dobj	expression,investigate
R1642	T6954	T6953	compound	protein,expression
R1643	T6955	T6951	punct	", ",generated
R1644	T6956	T6951	nsubj	we,generated
R1645	T6957	T6958	det	an,antibody
R1646	T6958	T6951	dobj	antibody,generated
R1647	T6959	T6958	prep	against,antibody
R1648	T6960	T6961	det	the,portion
R1649	T6961	T6959	pobj	portion,against
R1650	T6962	T6963	npadvmod	C,terminal
R1651	T6963	T6961	amod	terminal,portion
R1652	T6964	T6963	punct	-,terminal
R1653	T6965	T6961	prep	of,portion
R1654	T6966	T6967	det	the,protein
R1655	T6967	T6965	pobj	protein,of
R1656	T6968	T6951	punct	.,generated
R1657	T6970	T6971	det	The,antibody
R1658	T6971	T6972	nsubjpass	antibody,raised
R1659	T6973	T6972	auxpass	was,raised
R1660	T6974	T6972	prep	against,raised
R1661	T6975	T6976	det	a,region
R1662	T6976	T6974	pobj	region,against
R1663	T6977	T6976	amod	unique,region
R1664	T6978	T6976	acl	lacking,region
R1665	T6979	T6980	det	the,domain
R1666	T6980	T6978	dobj	domain,lacking
R1667	T6981	T6980	compound	DM,domain
R1668	T6982	T6972	prep	in,raised
R1669	T6983	T6982	pobj	order,in
R1670	T6984	T6985	aux	to,avoid
R1671	T6985	T6983	acl	avoid,order
R1672	T6986	T6985	dobj	cross-reaction,avoid
R1673	T6987	T6986	prep	with,cross-reaction
R1674	T6988	T6989	amod	other,proteins
R1675	T6989	T6987	pobj	proteins,with
R1676	T6990	T6991	compound	DM,domain
R1677	T6991	T6989	compound	domain,proteins
R1678	T6992	T6972	punct	.,raised
R1679	T6994	T6995	amod	Immunofluorescent,staining
R1680	T6995	T6996	nsubj	staining,showed
R1681	T6997	T6995	prep	with,staining
R1682	T6998	T6999	amod	purified,antisera
R1683	T6999	T6997	pobj	antisera,with
R1684	T7000	T6999	compound	DMRT7,antisera
R1685	T7001	T7002	mark	that,expressed
R1686	T7002	T6996	ccomp	expressed,showed
R1687	T7003	T7004	compound	DMRT7,protein
R1688	T7004	T7002	nsubjpass	protein,expressed
R1689	T7005	T7002	auxpass	is,expressed
R1690	T7006	T7002	advmod	predominantly,expressed
R1691	T7007	T7002	prep	in,expressed
R1692	T7008	T7009	amod	mid,pachytene
R1693	T7009	T7014	compound	pachytene,spermatocytes
R1694	T7010	T7008	punct	-,mid
R1695	T7011	T7008	prep	to,mid
R1696	T7012	T7011	amod	late,to
R1697	T7013	T7009	punct	-,pachytene
R1698	T7014	T7007	pobj	spermatocytes,in
R1699	T7015	T7016	punct	(,1C
R1700	T7016	T7014	parataxis	1C,spermatocytes
R1701	T7017	T7016	compound	Figure,1C
R1702	T7018	T7016	punct	),1C
R1703	T7019	T7007	punct	", ",in
R1704	T7020	T7021	advmod	as,as
R1705	T7021	T7007	cc	as,in
R1706	T7022	T7021	advmod	well,as
R1707	T7023	T7007	conj	in,in
R1708	T7024	T7023	pobj	sperm,in
R1709	T7025	T7002	punct	", ",expressed
R1710	T7026	T7002	cc	and,expressed
R1711	T7027	T7002	conj	is,expressed
R1712	T7028	T7027	neg	not,is
R1713	T7029	T7027	acomp	detectable,is
R1714	T7030	T7027	prep	in,is
R1715	T7031	T7032	amod	other,types
R1716	T7032	T7030	pobj	types,in
R1717	T7033	T7034	compound	germ,cell
R1718	T7034	T7032	compound	cell,types
R1719	T7035	T7032	prep	including,types
R1720	T7036	T7035	pobj	spermatogonia,including
R1721	T7037	T7036	cc	and,spermatogonia
R1722	T7038	T7039	amod	round,spermatids
R1723	T7039	T7036	conj	spermatids,spermatogonia
R1724	T7040	T6996	punct	.,showed
R1725	T7042	T7043	nsubj	We,detect
R1726	T7044	T7043	aux	did,detect
R1727	T7045	T7043	neg	not,detect
R1728	T7046	T7047	compound	DMRT7,protein
R1729	T7047	T7043	dobj	protein,detect
R1730	T7048	T7043	prep	in,detect
R1731	T7049	T7050	amod	somatic,cells
R1732	T7050	T7048	pobj	cells,in
R1733	T7051	T7052	amod	such,as
R1734	T7052	T7050	prep	as,cells
R1735	T7053	T7054	compound	Sertoli,cells
R1736	T7054	T7052	pobj	cells,as
R1737	T7055	T7054	punct	", ",cells
R1738	T7056	T7057	amod	peritubular,cells
R1739	T7057	T7054	conj	cells,cells
R1740	T7058	T7057	amod	myoid,cells
R1741	T7059	T7057	punct	", ",cells
R1742	T7060	T7057	cc	or,cells
R1743	T7061	T7062	compound	Leydig,cells
R1744	T7062	T7057	conj	cells,cells
R1745	T7063	T7043	punct	.,detect
R1746	T7065	T7066	aux	To,determine
R1747	T7066	T7069	advcl	determine,stained
R1748	T7067	T7068	advmod	more,precisely
R1749	T7068	T7066	advmod	precisely,determine
R1750	T7070	T7071	det	the,stages
R1751	T7071	T7066	dobj	stages,determine
R1752	T7072	T7071	compound	pachytene,stages
R1753	T7073	T7071	prep	of,stages
R1754	T7074	T7075	compound	DMRT7,expression
R1755	T7075	T7073	pobj	expression,of
R1756	T7076	T7069	punct	", ",stained
R1757	T7077	T7069	nsubj	we,stained
R1758	T7078	T7069	advmod	double,stained
R1759	T7079	T7069	punct	-,stained
R1760	T7080	T7069	prep	with,stained
R1761	T7081	T7082	det	an,antibody
R1762	T7082	T7080	pobj	antibody,with
R1763	T7083	T7082	prep	to,antibody
R1764	T7084	T7083	pobj	GATA1,to
R1765	T7085	T7084	punct	", ",GATA1
R1766	T7086	T7087	dep	which,expressed
R1767	T7087	T7084	relcl	expressed,GATA1
R1768	T7088	T7087	auxpass	is,expressed
R1769	T7089	T7087	prep	in,expressed
R1770	T7090	T7091	compound	Sertoli,cells
R1771	T7091	T7089	pobj	cells,in
R1772	T7092	T7091	prep	from,cells
R1773	T7093	T7094	nmod	stages,VII
R1774	T7094	T7092	pobj	VII,from
R1775	T7095	T7094	prep	to,VII
R1776	T7096	T7095	pobj	IX,to
R1777	T7097	T7098	punct	[,38
R1778	T7098	T7069	parataxis	38,stained
R1779	T7099	T7098	punct	],38
R1780	T7100	T7069	punct	.,stained
R1781	T7102	T7103	nsubj	This,confirmed
R1782	T7104	T7105	mark	that,expressed
R1783	T7105	T7103	ccomp	expressed,confirmed
R1784	T7106	T7105	nsubjpass	DMRT7,expressed
R1785	T7107	T7105	auxpass	is,expressed
R1786	T7108	T7105	prep	in,expressed
R1787	T7109	T7110	amod	mid,pachytene
R1788	T7110	T7115	compound	pachytene,spermatocytes
R1789	T7111	T7109	punct	-,mid
R1790	T7112	T7109	prep	to,mid
R1791	T7113	T7112	amod	late,to
R1792	T7114	T7110	punct	-,pachytene
R1793	T7115	T7108	pobj	spermatocytes,in
R1794	T7116	T7105	punct	", ",expressed
R1795	T7117	T7105	advcl	starting,expressed
R1796	T7118	T7119	advmod	slightly,earlier
R1797	T7119	T7117	advmod	earlier,starting
R1798	T7120	T7119	prep	than,earlier
R1799	T7121	T7120	pobj	stage,than
R1800	T7122	T7121	nummod	VII,stage
R1801	T7123	T7117	cc	and,starting
R1802	T7124	T7117	conj	extending,starting
R1803	T7125	T7124	prep	through,extending
R1804	T7126	T7125	pobj	stage,through
R1805	T7127	T7126	nummod	IX,stage
R1806	T7128	T7129	punct	(,data
R1807	T7129	T7103	meta	data,confirmed
R1808	T7130	T7129	amod	unpublished,data
R1809	T7131	T7129	punct	),data
R1810	T7132	T7103	punct	.,confirmed
R1811	T7134	T7135	prep	Within,concentrated
R1812	T7136	T7137	compound	pachytene,spermatocytes
R1813	T7137	T7134	pobj	spermatocytes,Within
R1814	T7138	T7135	punct	", ",concentrated
R1815	T7139	T7135	nsubjpass	DMRT7,concentrated
R1816	T7140	T7135	auxpass	is,concentrated
R1817	T7141	T7135	prep	in,concentrated
R1818	T7142	T7143	det	the,body
R1819	T7143	T7141	pobj	body,in
R1820	T7144	T7143	compound	XY,body
R1821	T7145	T7143	punct	", ",body
R1822	T7146	T7143	cc	or,body
R1823	T7147	T7148	compound	sex,body
R1824	T7148	T7143	conj	body,body
R1825	T7149	T7143	punct	", ",body
R1826	T7150	T7151	det	a,domain
R1827	T7151	T7143	appos	domain,body
R1828	T7152	T7153	advmod	densely,staining
R1829	T7153	T7151	amod	staining,domain
R1830	T7154	T7151	compound	chromatin,domain
R1831	T7155	T7156	dep	that,harbors
R1832	T7156	T7151	relcl	harbors,domain
R1833	T7157	T7158	det	the,chromosomes
R1834	T7158	T7156	dobj	chromosomes,harbors
R1835	T7159	T7158	compound	sex,chromosomes
R1836	T7160	T7135	punct	.,concentrated
R1837	T7162	T7163	nsubj	These,undergo
R1838	T7164	T7165	amod	transcriptional,inactivation
R1839	T7165	T7163	dobj	inactivation,undergo
R1840	T7166	T7165	cc	and,inactivation
R1841	T7167	T7165	conj	heterochromatinization,inactivation
R1842	T7168	T7163	prep	as,undergo
R1843	T7169	T7170	det	a,result
R1844	T7170	T7168	pobj	result,as
R1845	T7171	T7170	prep	of,result
R1846	T7172	T7173	poss	their,pairing
R1847	T7173	T7171	pobj	pairing,of
R1848	T7174	T7173	amod	incomplete,pairing
R1849	T7175	T7173	prep	during,pairing
R1850	T7176	T7175	pobj	prophase,during
R1851	T7177	T7176	prep	of,prophase
R1852	T7178	T7179	amod	mammalian,meiosis
R1853	T7179	T7177	pobj	meiosis,of
R1854	T7180	T7179	amod	male,meiosis
R1855	T7181	T7182	punct	[,17
R1856	T7182	T7163	parataxis	17,undergo
R1857	T7183	T7182	punct	],17
R1858	T7184	T7163	punct	.,undergo
R1859	T7186	T7187	aux	To,verify
R1860	T7187	T7188	advcl	verify,stained
R1861	T7189	T7190	compound	DMRT7,expression
R1862	T7190	T7187	dobj	expression,verify
R1863	T7191	T7190	compound	protein,expression
R1864	T7192	T7187	prep	in,verify
R1865	T7193	T7194	det	the,body
R1866	T7194	T7192	pobj	body,in
R1867	T7195	T7194	compound	XY,body
R1868	T7196	T7188	punct	", ",stained
R1869	T7197	T7188	nsubj	we,stained
R1870	T7198	T7188	advmod	double,stained
R1871	T7199	T7188	punct	-,stained
R1872	T7200	T7201	compound	mouse,testis
R1873	T7201	T7202	compound	testis,sections
R1874	T7202	T7188	dobj	sections,stained
R1875	T7203	T7188	prep	for,stained
R1876	T7204	T7203	pobj	DMRT7,for
R1877	T7205	T7204	cc	and,DMRT7
R1878	T7206	T7207	amod	small,modifier
R1879	T7207	T7204	conj	modifier,DMRT7
R1880	T7208	T7209	npadvmod	ubiquitin,related
R1881	T7209	T7207	amod	related,modifier
R1882	T7210	T7209	punct	-,related
R1883	T7211	T7207	nummod	1,modifier
R1884	T7212	T7207	punct	(,modifier
R1885	T7213	T7207	appos	SUMO,modifier
R1886	T7214	T7213	punct	-,SUMO
R1887	T7215	T7213	nummod	1,SUMO
R1888	T7216	T7207	punct	),modifier
R1889	T7217	T7207	punct	", ",modifier
R1890	T7218	T7219	dep	which,concentrated
R1891	T7219	T7207	relcl	concentrated,modifier
R1892	T7220	T7219	auxpass	is,concentrated
R1893	T7221	T7219	prep	in,concentrated
R1894	T7222	T7223	det	the,body
R1895	T7223	T7221	pobj	body,in
R1896	T7224	T7223	compound	XY,body
R1897	T7225	T7219	prep	during,concentrated
R1898	T7226	T7225	pobj	pachynema,during
R1899	T7227	T7228	punct	[,40
R1900	T7228	T7188	parataxis	40,stained
R1901	T7229	T7228	nummod	39,40
R1902	T7230	T7228	punct	",",40
R1903	T7231	T7228	punct	],40
R1904	T7232	T7188	punct	.,stained
R1905	T7234	T7235	nsubjpass	DMRT7,colocalized
R1906	T7236	T7234	cc	and,DMRT7
R1907	T7237	T7234	conj	SUMO,DMRT7
R1908	T7238	T7237	punct	-,SUMO
R1909	T7239	T7237	nummod	1,SUMO
R1910	T7240	T7235	auxpass	were,colocalized
R1911	T7241	T7235	punct	", ",colocalized
R1912	T7242	T7235	advcl	confirming,colocalized
R1913	T7243	T7244	mark	that,localized
R1914	T7244	T7242	ccomp	localized,confirming
R1915	T7245	T7246	compound	DMRT7,protein
R1916	T7246	T7244	nsubjpass	protein,localized
R1917	T7247	T7244	auxpass	is,localized
R1918	T7248	T7244	advmod	preferentially,localized
R1919	T7249	T7244	prep	to,localized
R1920	T7250	T7251	det	the,body
R1921	T7251	T7249	pobj	body,to
R1922	T7252	T7251	compound	XY,body
R1923	T7253	T7254	punct	(,1D
R1924	T7254	T7235	parataxis	1D,colocalized
R1925	T7255	T7254	compound	Figure,1D
R1926	T7256	T7254	punct	),1D
R1927	T7257	T7235	punct	.,colocalized
R1928	T7259	T7260	nsubj	We,confirmed
R1929	T7261	T7260	advmod	also,confirmed
R1930	T7262	T7263	compound	XY,localization
R1931	T7263	T7260	dobj	localization,confirmed
R1932	T7264	T7263	compound	body,localization
R1933	T7265	T7263	prep	of,localization
R1934	T7266	T7265	pobj	DMRT7,of
R1935	T7267	T7260	prep	by,confirmed
R1936	T7268	T7269	amod	double,staining
R1937	T7269	T7267	pobj	staining,by
R1938	T7270	T7269	prep	for,staining
R1939	T7271	T7272	amod	other,markers
R1940	T7272	T7270	pobj	markers,for
R1941	T7273	T7272	prep	including,markers
R1942	T7274	T7275	compound	Ub,H2A
R1943	T7275	T7273	pobj	H2A,including
R1944	T7276	T7275	punct	-,H2A
R1945	T7277	T7275	cc	and,H2A
R1946	T7278	T7275	conj	γH2AX,H2A
R1947	T7279	T7280	punct	(,data
R1948	T7280	T7260	meta	data,confirmed
R1949	T7281	T7280	amod	unpublished,data
R1950	T7282	T7280	punct	),data
R1951	T7283	T7260	punct	.,confirmed
R1952	T7285	T7286	nsubjpass	DMRT7,localized
R1953	T7287	T7286	auxpass	is,localized
R1954	T7288	T7286	neg	not,localized
R1955	T7289	T7286	advmod	preferentially,localized
R1956	T7290	T7286	prep	to,localized
R1957	T7291	T7292	det	the,body
R1958	T7292	T7290	pobj	body,to
R1959	T7293	T7292	compound	XY,body
R1960	T7294	T7286	prep	at,localized
R1961	T7295	T7296	det	all,stages
R1962	T7296	T7294	pobj	stages,at
R1963	T7297	T7286	cc	but,localized
R1964	T7298	T7299	advmod	instead,is
R1965	T7299	T7286	conj	is,localized
R1966	T7300	T7299	acomp	dynamic,is
R1967	T7301	T7286	punct	.,localized
R1968	T7303	T7304	prep	Based,appears
R1969	T7305	T7303	prep	on,Based
R1970	T7306	T7307	amod	epithelial,staging
R1971	T7307	T7305	pobj	staging,on
R1972	T7308	T7304	punct	", ",appears
R1973	T7309	T7304	nsubj	it,appears
R1974	T7310	T7311	mark	that,localizes
R1975	T7311	T7304	ccomp	localizes,appears
R1976	T7312	T7311	nsubj	DMRT7,localizes
R1977	T7313	T7311	prep	to,localizes
R1978	T7314	T7315	det	the,body
R1979	T7315	T7313	pobj	body,to
R1980	T7316	T7315	compound	XY,body
R1981	T7317	T7311	prep	from,localizes
R1982	T7318	T7319	amod	mid,pachynema
R1983	T7319	T7317	pobj	pachynema,from
R1984	T7320	T7318	punct	-,mid
R1985	T7321	T7318	prep	to,mid
R1986	T7322	T7321	amod	late,to
R1987	T7323	T7319	punct	-,pachynema
R1988	T7324	T7311	punct	", ",localizes
R1989	T7325	T7311	conj	becomes,localizes
R1990	T7326	T7327	advmod	diffusely,distributed
R1991	T7327	T7325	acomp	distributed,becomes
R1992	T7328	T7325	prep	in,becomes
R1993	T7329	T7330	amod	late,pachynema
R1994	T7330	T7328	pobj	pachynema,in
R1995	T7331	T7330	punct	-,pachynema
R1996	T7332	T7325	punct	", ",becomes
R1997	T7333	T7325	cc	and,becomes
R1998	T7334	T7325	conj	disappears,becomes
R1999	T7335	T7334	prep	in,disappears
R2000	T7336	T7335	pobj	diplonema,in
R2001	T7337	T7338	punct	(,data
R2002	T7338	T7304	meta	data,appears
R2003	T7339	T7338	amod	unpublished,data
R2004	T7340	T7338	punct	),data
R2005	T7341	T7304	punct	.,appears
R2006	T7343	T7344	det	This,localization
R2007	T7344	T7345	nsubjpass	localization,confirmed
R2008	T7346	T7345	auxpass	was,confirmed
R2009	T7347	T7345	prep	by,confirmed
R2010	T7348	T7347	pobj	staining,by
R2011	T7349	T7348	prep	of,staining
R2012	T7350	T7351	amod	meiotic,spreads
R2013	T7351	T7349	pobj	spreads,of
R2014	T7352	T7353	punct	(,S1
R2015	T7353	T7345	parataxis	S1,confirmed
R2016	T7354	T7353	compound	Figure,S1
R2017	T7355	T7353	punct	),S1
R2018	T7356	T7345	punct	.,confirmed
R2019	T7358	T7359	nsubjpass	DMRT7,localized
R2020	T7360	T7359	advmod	also,localized
R2021	T7361	T7359	auxpass	is,localized
R2022	T7362	T7359	advmod	specifically,localized
R2023	T7363	T7359	prep	in,localized
R2024	T7364	T7363	pobj	sperm,in
R2025	T7365	T7359	punct	", ",localized
R2026	T7366	T7359	prep	with,localized
R2027	T7367	T7368	compound	antibody,staining
R2028	T7368	T7366	pobj	staining,with
R2029	T7369	T7370	advmod	mainly,in
R2030	T7370	T7368	prep	in,staining
R2031	T7371	T7372	det	the,ring
R2032	T7372	T7370	pobj	ring,in
R2033	T7373	T7372	amod	perinuclear,ring
R2034	T7374	T7372	prep	of,ring
R2035	T7375	T7376	det	the,manchette
R2036	T7376	T7374	pobj	manchette,of
R2037	T7377	T7378	compound	sperm,head
R2038	T7378	T7376	compound	head,manchette
R2039	T7379	T7359	punct	.,localized
R2040	T7381	T7382	det	This,staining
R2041	T7382	T7383	nsubj	staining,coincided
R2042	T7384	T7383	prep	with,coincided
R2043	T7385	T7386	det	the,stages
R2044	T7386	T7384	pobj	stages,with
R2045	T7387	T7386	amod	epithelial,stages
R2046	T7388	T7389	prep	in,localizes
R2047	T7389	T7386	relcl	localizes,stages
R2048	T7390	T7388	pobj	which,in
R2049	T7391	T7389	nsubj	DMRT7,localizes
R2050	T7392	T7389	prep	to,localizes
R2051	T7393	T7394	det	the,body
R2052	T7394	T7392	pobj	body,to
R2053	T7395	T7394	compound	XY,body
R2054	T7396	T7394	prep	in,body
R2055	T7397	T7396	pobj	spermatocytes,in
R2056	T7398	T7399	punct	(,1C
R2057	T7399	T7383	parataxis	1C,coincided
R2058	T7400	T7399	compound	Figure,1C
R2059	T7401	T7399	cc	and,1C
R2060	T7402	T7399	conj	1D,1C
R2061	T7403	T7399	punct	),1C
R2062	T7404	T7383	punct	.,coincided
R2067	T8160	T8161	amod	Targeted,Deletion
R2068	T8162	T8161	prep	of,Deletion
R2069	T8163	T8162	pobj	Dmrt7,of
R2070	T8165	T8166	aux	To,establish
R2071	T8166	T8167	advcl	establish,generated
R2072	T8168	T8169	det	the,requirement
R2073	T8169	T8166	dobj	requirement,establish
R2074	T8170	T8169	amod	functional,requirement
R2075	T8171	T8169	prep	for,requirement
R2076	T8172	T8171	pobj	Dmrt7,for
R2077	T8173	T8167	punct	", ",generated
R2078	T8174	T8167	nsubj	we,generated
R2079	T8175	T8176	nmod	Dmrt7,mice
R2080	T8176	T8167	dobj	mice,generated
R2081	T8177	T8175	punct	−,Dmrt7
R2082	T8178	T8175	punct	/,Dmrt7
R2083	T8179	T8175	punct	−,Dmrt7
R2084	T8180	T8167	prep	by,generated
R2085	T8181	T8182	amod	targeted,disruption
R2086	T8182	T8180	pobj	disruption,by
R2087	T8183	T8182	prep	in,disruption
R2088	T8184	T8185	amod	embryonic,stem
R2089	T8185	T8186	nmod	stem,cells
R2090	T8186	T8183	pobj	cells,in
R2091	T8187	T8185	punct	(,stem
R2092	T8188	T8185	appos	ES,stem
R2093	T8189	T8186	punct	),cells
R2094	T8190	T8182	acl	using,disruption
R2095	T8191	T8192	det	a,strategy
R2096	T8192	T8190	dobj	strategy,using
R2097	T8193	T8192	acl	diagrammed,strategy
R2098	T8194	T8193	prep	in,diagrammed
R2099	T8195	T8196	compound	Figure,S2A
R2100	T8196	T8194	pobj	S2A,in
R2101	T8197	T8167	punct	.,generated
R2102	T8199	T8200	det	The,gene
R2103	T8200	T8202	nsubj	gene,has
R2104	T8201	T8200	compound	Dmrt7,gene
R2105	T8203	T8204	nummod	nine,exons
R2106	T8204	T8202	dobj	exons,has
R2107	T8205	T8204	prep	with,exons
R2108	T8206	T8207	det	the,domain
R2109	T8207	T8205	pobj	domain,with
R2110	T8208	T8207	compound	DM,domain
R2111	T8209	T8207	acl	encoded,domain
R2112	T8210	T8209	agent	by,encoded
R2113	T8211	T8212	det	the,exons
R2114	T8212	T8210	pobj	exons,by
R2115	T8213	T8212	amod	second,exons
R2116	T8214	T8213	cc	and,second
R2117	T8215	T8213	conj	third,second
R2118	T8216	T8202	punct	.,has
R2119	T8218	T8219	mark	Because,is
R2120	T8219	T8223	advcl	is,generated
R2121	T8220	T8221	det	the,domain
R2122	T8221	T8219	nsubj	domain,is
R2123	T8222	T8221	compound	DM,domain
R2124	T8224	T8219	acomp	essential,is
R2125	T8225	T8224	prep	for,essential
R2126	T8226	T8225	pobj	function,for
R2127	T8227	T8226	prep	of,function
R2128	T8228	T8229	amod	other,genes
R2129	T8229	T8227	pobj	genes,of
R2130	T8230	T8229	punct	", ",genes
R2131	T8231	T8229	prep	including,genes
R2132	T8232	T8231	pobj	mab,including
R2133	T8233	T8232	punct	-,mab
R2134	T8234	T8232	nummod	3,mab
R2135	T8235	T8232	punct	", ",mab
R2136	T8236	T8232	conj	mab,mab
R2137	T8237	T8236	punct	-,mab
R2138	T8238	T8236	nummod	23,mab
R2139	T8239	T8236	punct	", ",mab
R2140	T8240	T8236	cc	and,mab
R2141	T8241	T8236	conj	dsx,mab
R2142	T8242	T8243	punct	[,41
R2143	T8243	T8219	parataxis	41,is
R2144	T8244	T8243	nummod	18,41
R2145	T8245	T8243	punct	",",41
R2146	T8246	T8243	nummod	19,41
R2147	T8247	T8243	punct	",",41
R2148	T8248	T8243	punct	],41
R2149	T8249	T8223	punct	", ",generated
R2150	T8250	T8223	nsubj	we,generated
R2151	T8251	T8252	det	a,allele
R2152	T8252	T8223	dobj	allele,generated
R2153	T8253	T8254	advmod	conditionally,targeted
R2154	T8254	T8252	amod	targeted,allele
R2155	T8255	T8252	punct	“,allele
R2156	T8256	T8252	amod	floxed,allele
R2157	T8257	T8252	punct	”,allele
R2158	T8258	T8259	prep	in,flanked
R2159	T8259	T8252	relcl	flanked,allele
R2160	T8260	T8258	pobj	which,in
R2161	T8261	T8262	det	the,exons
R2162	T8262	T8259	nsubjpass	exons,flanked
R2163	T8263	T8262	nmod	DM,exons
R2164	T8264	T8265	npadvmod	domain,containing
R2165	T8265	T8262	amod	containing,exons
R2166	T8266	T8265	punct	–,containing
R2167	T8267	T8262	prep	of,exons
R2168	T8268	T8267	pobj	Dmrt7,of
R2169	T8269	T8259	auxpass	are,flanked
R2170	T8270	T8259	prep	by,flanked
R2171	T8271	T8272	compound	recognition,sites
R2172	T8272	T8270	pobj	sites,by
R2173	T8273	T8259	prep	for,flanked
R2174	T8274	T8275	det	the,recombinase
R2175	T8275	T8273	pobj	recombinase,for
R2176	T8276	T8275	compound	Cre,recombinase
R2177	T8277	T8278	punct	(,sites
R2178	T8278	T8223	parataxis	sites,generated
R2179	T8279	T8278	compound	loxP,sites
R2180	T8280	T8278	punct	),sites
R2181	T8281	T8223	punct	.,generated
R2182	T8283	T8284	det	The,vector
R2183	T8284	T8286	nsubj	vector,contained
R2184	T8285	T8284	compound	targeting,vector
R2185	T8287	T8286	advmod	also,contained
R2186	T8288	T8289	det	a,cassette
R2187	T8289	T8286	dobj	cassette,contained
R2188	T8290	T8289	compound	neomycin,cassette
R2189	T8291	T8289	compound	resistance,cassette
R2190	T8292	T8293	punct	(,neo
R2191	T8293	T8289	parataxis	neo,cassette
R2192	T8294	T8293	punct	),neo
R2193	T8295	T8289	acl	flanked,cassette
R2194	T8296	T8295	prep	by,flanked
R2195	T8297	T8298	compound	Flpe,sites
R2196	T8298	T8296	pobj	sites,by
R2197	T8299	T8298	compound	recognition,sites
R2198	T8300	T8286	punct	.,contained
R2199	T8302	T8303	det	The,removal
R2200	T8303	T8304	nsubj	removal,eliminates
R2201	T8305	T8303	prep	of,removal
R2202	T8306	T8307	det	these,sequences
R2203	T8307	T8305	pobj	sequences,of
R2204	T8308	T8303	prep	by,removal
R2205	T8309	T8310	npadvmod	Cre,mediated
R2206	T8310	T8312	amod	mediated,recombination
R2207	T8311	T8310	punct	-,mediated
R2208	T8312	T8308	pobj	recombination,by
R2209	T8313	T8314	det	the,domain
R2210	T8314	T8304	dobj	domain,eliminates
R2211	T8315	T8314	compound	DM,domain
R2212	T8316	T8314	cc	and,domain
R2213	T8317	T8318	det	the,site
R2214	T8318	T8314	conj	site,domain
R2215	T8319	T8318	amod	translational,site
R2216	T8320	T8318	compound	start,site
R2217	T8321	T8304	punct	", ",eliminates
R2218	T8322	T8323	advmod	thus,generating
R2219	T8323	T8304	advcl	generating,eliminates
R2220	T8324	T8325	det	a,allele
R2221	T8325	T8323	dobj	allele,generating
R2222	T8326	T8325	amod	putative,allele
R2223	T8327	T8325	amod	null,allele
R2224	T8328	T8304	punct	.,eliminates
R2225	T8330	T8331	nsubj	We,identified
R2226	T8332	T8333	nummod	three,clones
R2227	T8333	T8331	dobj	clones,identified
R2228	T8334	T8335	advmod	homologously,targeted
R2229	T8335	T8333	amod	targeted,clones
R2230	T8336	T8337	compound	ES,cell
R2231	T8337	T8333	compound	cell,clones
R2232	T8338	T8331	prep	by,identified
R2233	T8339	T8340	compound	Southern,blotting
R2234	T8340	T8338	pobj	blotting,by
R2235	T8341	T8342	punct	(,S2B
R2236	T8342	T8331	parataxis	S2B,identified
R2237	T8343	T8342	compound	Figure,S2B
R2238	T8344	T8342	punct	),S2B
R2239	T8345	T8331	cc	and,identified
R2240	T8346	T8331	conj	injected,identified
R2241	T8347	T8346	dobj	cells,injected
R2242	T8348	T8347	prep	from,cells
R2243	T8349	T8350	nummod	two,clones
R2244	T8350	T8348	pobj	clones,from
R2245	T8351	T8346	prep	into,injected
R2246	T8352	T8353	nmod	C57BL,blastocysts
R2247	T8353	T8351	pobj	blastocysts,into
R2248	T8354	T8352	punct	/,C57BL
R2249	T8355	T8352	nummod	6,C57BL
R2250	T8356	T8331	punct	.,identified
R2251	T8358	T8359	amod	Chimeric,animals
R2252	T8359	T8360	nsubj	animals,transmitted
R2253	T8361	T8359	prep	from,animals
R2254	T8362	T8363	det	both,lines
R2255	T8363	T8361	pobj	lines,from
R2256	T8364	T8363	compound	cell,lines
R2257	T8365	T8366	det	the,allele
R2258	T8366	T8360	dobj	allele,transmitted
R2259	T8367	T8366	amod	targeted,allele
R2260	T8368	T8360	prep	through,transmitted
R2261	T8369	T8370	det	the,line
R2262	T8370	T8368	pobj	line,through
R2263	T8371	T8370	compound	germ,line
R2264	T8372	T8360	punct	.,transmitted
R2265	T8374	T8375	amod	Targeted,animals
R2266	T8375	T8376	nsubjpass	animals,bred
R2267	T8377	T8376	auxpass	were,bred
R2268	T8378	T8376	prep	to,bred
R2269	T8379	T8380	compound	β,actin
R2270	T8380	T8382	compound	actin,mice
R2271	T8381	T8380	punct	-,actin
R2272	T8382	T8378	pobj	mice,to
R2273	T8383	T8382	compound	Cre,mice
R2274	T8384	T8385	aux	to,delete
R2275	T8385	T8376	advcl	delete,bred
R2276	T8386	T8387	det	the,exons
R2277	T8387	T8385	dobj	exons,delete
R2278	T8388	T8389	compound	DM,domain
R2279	T8389	T8390	npadvmod	domain,encoding
R2280	T8390	T8387	amod	encoding,exons
R2281	T8391	T8390	punct	–,encoding
R2282	T8392	T8376	punct	", ",bred
R2283	T8393	T8376	advcl	generating,bred
R2284	T8394	T8395	det	the,allele
R2285	T8395	T8393	dobj	allele,generating
R2286	T8396	T8395	compound	Dmrt7,allele
R2287	T8397	T8395	punct	−,allele
R2288	T8398	T8376	punct	", ",bred
R2289	T8399	T8376	cc	or,bred
R2290	T8400	T8376	conj	to,bred
R2291	T8401	T8402	nmod	Flpe,mice
R2292	T8402	T8400	pobj	mice,to
R2293	T8403	T8402	amod	transgenic,mice
R2294	T8404	T8405	aux	to,delete
R2295	T8405	T8400	advcl	delete,to
R2296	T8406	T8407	det	the,cassette
R2297	T8407	T8405	dobj	cassette,delete
R2298	T8408	T8407	compound	neo,cassette
R2299	T8409	T8400	punct	", ",to
R2300	T8410	T8400	advcl	generating,to
R2301	T8411	T8412	det	the,allele
R2302	T8412	T8410	dobj	allele,generating
R2303	T8413	T8412	compound	Dmrt7flox,allele
R2304	T8414	T8376	punct	.,bred
R2305	T8416	T8417	nmod	Dmrt7,mice
R2306	T8417	T8421	nsubjpass	mice,interbred
R2307	T8418	T8416	punct	+,Dmrt7
R2308	T8419	T8416	punct	/,Dmrt7
R2309	T8420	T8416	punct	−,Dmrt7
R2310	T8422	T8421	auxpass	were,interbred
R2311	T8423	T8424	aux	to,generate
R2312	T8424	T8421	advcl	generate,interbred
R2313	T8425	T8426	nmod	Dmrt7,mice
R2314	T8426	T8424	dobj	mice,generate
R2315	T8427	T8425	punct	−,Dmrt7
R2316	T8428	T8425	punct	/,Dmrt7
R2317	T8429	T8425	punct	−,Dmrt7
R2318	T8430	T8421	punct	.,interbred
R2319	T8432	T8433	aux	To,confirm
R2320	T8433	T8434	advcl	confirm,stained
R2321	T8435	T8436	det	the,lack
R2322	T8436	T8433	dobj	lack,confirm
R2323	T8437	T8436	prep	of,lack
R2324	T8438	T8439	amod	functional,protein
R2325	T8439	T8437	pobj	protein,of
R2326	T8440	T8439	compound	DMRT7,protein
R2327	T8441	T8439	prep	in,protein
R2328	T8442	T8443	nmod	Dmrt7,testes
R2329	T8443	T8441	pobj	testes,in
R2330	T8444	T8442	punct	−,Dmrt7
R2331	T8445	T8442	punct	/,Dmrt7
R2332	T8446	T8442	punct	−,Dmrt7
R2333	T8447	T8434	punct	", ",stained
R2334	T8448	T8434	nsubj	we,stained
R2335	T8449	T8450	amod	meiotic,spreads
R2336	T8450	T8434	dobj	spreads,stained
R2337	T8451	T8450	prep	from,spreads
R2338	T8452	T8453	compound	Dmrt7,mutants
R2339	T8453	T8451	pobj	mutants,from
R2340	T8454	T8455	punct	(,S1
R2341	T8455	T8450	parataxis	S1,spreads
R2342	T8456	T8455	compound	Figure,S1
R2343	T8457	T8455	punct	),S1
R2344	T8458	T8450	cc	and,spreads
R2345	T8459	T8450	conj	sections,spreads
R2346	T8460	T8459	prep	from,sections
R2347	T8461	T8462	compound	mutant,testes
R2348	T8462	T8460	pobj	testes,from
R2349	T8463	T8464	punct	(,S2C
R2350	T8464	T8459	parataxis	S2C,sections
R2351	T8465	T8464	compound	Figure,S2C
R2352	T8466	T8464	punct	),S2C
R2353	T8467	T8434	cc	and,stained
R2354	T8468	T8434	conj	carried,stained
R2355	T8469	T8468	prt	out,carried
R2356	T8470	T8471	compound	western,blot
R2357	T8471	T8472	compound	blot,analysis
R2358	T8472	T8468	dobj	analysis,carried
R2359	T8473	T8474	punct	(,data
R2360	T8474	T8468	meta	data,carried
R2361	T8475	T8474	amod	unpublished,data
R2362	T8476	T8474	punct	),data
R2363	T8477	T8434	punct	.,stained
R2364	T8479	T8480	prep	In,detected
R2365	T8481	T8482	det	each,case
R2366	T8482	T8479	pobj	case,In
R2367	T8483	T8480	punct	", ",detected
R2368	T8484	T8480	nsubj	we,detected
R2369	T8485	T8486	det	no,protein
R2370	T8486	T8480	dobj	protein,detected
R2371	T8487	T8486	compound	DMRT7,protein
R2372	T8488	T8480	prep	in,detected
R2373	T8489	T8490	det	the,testes
R2374	T8490	T8488	pobj	testes,in
R2375	T8491	T8490	compound	mutant,testes
R2376	T8492	T8480	punct	.,detected
R2383	T9723	T9724	nsubjpass	Dmrt7,Required
R2384	T9725	T9724	auxpass	Is,Required
R2385	T9726	T9724	prep	for,Required
R2386	T9727	T9728	amod	Male,Gametogenesis
R2387	T9728	T9726	pobj	Gametogenesis,for
R2388	T9729	T9727	cc	but,Male
R2389	T9730	T9729	neg	Not,but
R2390	T9731	T9727	conj	Female,Male
R2391	T9733	T9734	nsubj	Breeding,produced
R2392	T9735	T9733	prep	of,Breeding
R2393	T9736	T9737	compound	Dmrt7,heterozygotes
R2394	T9737	T9735	pobj	heterozygotes,of
R2395	T9738	T9739	amod	homozygous,progeny
R2396	T9739	T9734	dobj	progeny,produced
R2397	T9740	T9739	compound	mutant,progeny
R2398	T9741	T9739	prep	of,progeny
R2399	T9742	T9743	det	both,sexes
R2400	T9743	T9741	pobj	sexes,of
R2401	T9744	T9734	prep	at,produced
R2402	T9745	T9746	det	the,frequency
R2403	T9746	T9744	pobj	frequency,at
R2404	T9747	T9746	amod	expected,frequency
R2405	T9748	T9749	punct	(,%
R2406	T9749	T9734	parataxis	%,produced
R2407	T9750	T9751	quantmod	63,264
R2408	T9751	T9749	dep	264,%
R2409	T9752	T9751	punct	/,264
R2410	T9753	T9749	punct	;,%
R2411	T9754	T9749	nummod	23,%
R2412	T9755	T9749	punct	),%
R2413	T9756	T9734	punct	.,produced
R2414	T9758	T9759	amod	Male,mutants
R2415	T9759	T9763	nsubj	mutants,were
R2416	T9760	T9758	cc	and,Male
R2417	T9761	T9758	conj	female,Male
R2418	T9762	T9759	amod	homozygous,mutants
R2419	T9764	T9763	acomp	viable,were
R2420	T9765	T9763	punct	", ",were
R2421	T9766	T9763	conj	grew,were
R2422	T9767	T9766	prep	to,grew
R2423	T9768	T9767	pobj	adulthood,to
R2424	T9769	T9766	advmod	normally,grew
R2425	T9770	T9766	punct	", ",grew
R2426	T9771	T9766	cc	and,grew
R2427	T9772	T9766	conj	exhibited,grew
R2428	T9773	T9774	amod	normal,behavior
R2429	T9774	T9772	dobj	behavior,exhibited
R2430	T9775	T9774	amod	sexual,behavior
R2431	T9776	T9763	punct	.,were
R2432	T9778	T9779	amod	Female,homozygotes
R2433	T9779	T9780	nsubj	homozygotes,were
R2434	T9781	T9780	acomp	fertile,were
R2435	T9782	T9780	punct	", ",were
R2436	T9783	T9780	conj	produced,were
R2437	T9784	T9783	dobj	litters,produced
R2438	T9785	T9784	prep	of,litters
R2439	T9786	T9787	amod	normal,size
R2440	T9787	T9785	pobj	size,of
R2441	T9788	T9783	punct	", ",produced
R2442	T9789	T9783	cc	and,produced
R2443	T9790	T9783	conj	had,produced
R2444	T9791	T9792	det	no,abnormalities
R2445	T9792	T9790	dobj	abnormalities,had
R2446	T9793	T9792	amod	obvious,abnormalities
R2447	T9794	T9792	amod	ovarian,abnormalities
R2448	T9795	T9796	mark	as,judged
R2449	T9796	T9790	advcl	judged,had
R2450	T9797	T9796	prep	by,judged
R2451	T9798	T9799	amod	histological,analysis
R2452	T9799	T9797	pobj	analysis,by
R2453	T9800	T9801	punct	(,data
R2454	T9801	T9790	meta	data,had
R2455	T9802	T9801	amod	unpublished,data
R2456	T9803	T9801	punct	),data
R2457	T9804	T9780	punct	.,were
R2458	T9806	T9807	prep	In,were
R2459	T9808	T9806	pobj	contrast,In
R2460	T9809	T9807	punct	", ",were
R2461	T9810	T9811	nmod	Dmrt7,mutant
R2462	T9811	T9813	compound	mutant,males
R2463	T9812	T9811	amod	homozygous,mutant
R2464	T9813	T9807	nsubj	males,were
R2465	T9814	T9815	advmod	completely,infertile
R2466	T9815	T9807	acomp	infertile,were
R2467	T9816	T9807	cc	and,were
R2468	T9817	T9807	conj	had,were
R2469	T9818	T9817	dobj	testes,had
R2470	T9819	T9820	quantmod	about,one
R2471	T9820	T9821	nummod	one,weight
R2472	T9821	T9818	npadvmod	weight,testes
R2473	T9822	T9820	punct	-,one
R2474	T9823	T9820	quantmod	third,one
R2475	T9824	T9821	det	the,weight
R2476	T9825	T9821	prep	of,weight
R2477	T9826	T9825	pobj	those,of
R2478	T9827	T9826	prep	of,those
R2479	T9828	T9829	amod	heterozygous,littermates
R2480	T9829	T9827	pobj	littermates,of
R2481	T9830	T9828	cc	or,heterozygous
R2482	T9831	T9832	amod	wild,type
R2483	T9832	T9828	conj	type,heterozygous
R2484	T9833	T9832	punct	-,type
R2485	T9834	T9829	amod	adult,littermates
R2486	T9835	T9836	punct	(,Figure
R2487	T9836	T9817	parataxis	Figure,had
R2488	T9837	T9836	nummod	2,Figure
R2489	T9838	T9836	punct	),Figure
R2490	T9839	T9807	punct	.,were
R2491	T9841	T9842	aux	To,determine
R2492	T9842	T9843	advcl	determine,compared
R2493	T9844	T9845	advmod	when,begins
R2494	T9845	T9842	ccomp	begins,determine
R2495	T9846	T9847	amod	defective,development
R2496	T9847	T9845	nsubj	development,begins
R2497	T9848	T9847	compound	testis,development
R2498	T9849	T9845	prep	in,begins
R2499	T9850	T9851	compound	Dmrt7,mutants
R2500	T9851	T9849	pobj	mutants,in
R2501	T9852	T9843	punct	", ",compared
R2502	T9853	T9843	nsubj	we,compared
R2503	T9854	T9855	det	the,testes
R2504	T9855	T9843	dobj	testes,compared
R2505	T9856	T9855	prep	of,testes
R2506	T9857	T9858	amod	wild,type
R2507	T9858	T9860	nmod	type,littermates
R2508	T9859	T9858	punct	-,type
R2509	T9860	T9856	pobj	littermates,of
R2510	T9861	T9858	cc	and,type
R2511	T9862	T9858	conj	mutant,type
R2512	T9863	T9843	prep	during,compared
R2513	T9864	T9865	det	the,wave
R2514	T9865	T9863	pobj	wave,during
R2515	T9866	T9865	amod	first,wave
R2516	T9867	T9865	prep	of,wave
R2517	T9868	T9867	pobj	spermatogenesis,of
R2518	T9869	T9843	punct	.,compared
R2519	T9871	T9872	prep	Prior,appeared
R2520	T9873	T9871	prep	to,Prior
R2521	T9874	T9875	amod	postnatal,day
R2522	T9875	T9873	pobj	day,to
R2523	T9876	T9875	nummod	14,day
R2524	T9877	T9875	punct	(,day
R2525	T9878	T9875	appos	P14,day
R2526	T9879	T9872	punct	),appeared
R2527	T9880	T9872	punct	", ",appeared
R2528	T9881	T9882	compound	mutant,testes
R2529	T9882	T9872	nsubj	testes,appeared
R2530	T9883	T9884	advmod	histologically,normal
R2531	T9884	T9872	oprd	normal,appeared
R2532	T9885	T9872	cc	and,appeared
R2533	T9886	T9887	det	the,weights
R2534	T9887	T9889	nsubj	weights,were
R2535	T9888	T9887	compound	testis,weights
R2536	T9889	T9872	conj	were,appeared
R2537	T9890	T9889	acomp	similar,were
R2538	T9891	T9890	prep	to,similar
R2539	T9892	T9891	pobj	those,to
R2540	T9893	T9892	prep	of,those
R2541	T9894	T9895	amod	heterozygous,littermates
R2542	T9895	T9893	pobj	littermates,of
R2543	T9896	T9894	cc	and,heterozygous
R2544	T9897	T9898	amod	wild,type
R2545	T9898	T9894	conj	type,heterozygous
R2546	T9899	T9898	punct	-,type
R2547	T9900	T9889	punct	", ",were
R2548	T9901	T9889	advcl	indicating,were
R2549	T9902	T9903	mark	that,form
R2550	T9903	T9901	ccomp	form,indicating
R2551	T9904	T9903	nsubj	spermatogonia,form
R2552	T9905	T9904	cc	and,spermatogonia
R2553	T9906	T9907	amod	early,cells
R2554	T9907	T9904	conj	cells,spermatogonia
R2555	T9908	T9907	amod	meiotic,cells
R2556	T9909	T9907	compound	germ,cells
R2557	T9910	T9903	advmod	normally,form
R2558	T9911	T9912	punct	(,data
R2559	T9912	T9889	parataxis	data,were
R2560	T9913	T9914	compound	Figure,2B
R2561	T9914	T9912	dep	2B,data
R2562	T9915	T9912	punct	;,data
R2563	T9916	T9912	amod	unpublished,data
R2564	T9917	T9912	punct	),data
R2565	T9918	T9889	punct	.,were
R2566	T9920	T9921	advmod	Thereafter,ceased
R2567	T9922	T9921	punct	", ",ceased
R2568	T9923	T9924	det	the,testes
R2569	T9924	T9921	nsubj	testes,ceased
R2570	T9925	T9924	prep	of,testes
R2571	T9926	T9927	det	the,mice
R2572	T9927	T9925	pobj	mice,of
R2573	T9928	T9927	compound	Dmrt7,mice
R2574	T9929	T9927	compound	mutant,mice
R2575	T9930	T9931	aux	to,grow
R2576	T9931	T9921	xcomp	grow,ceased
R2577	T9932	T9921	cc	and,ceased
R2578	T9933	T9934	det	the,difference
R2579	T9934	T9936	nsubj	difference,was
R2580	T9935	T9934	compound	weight,difference
R2581	T9936	T9921	conj	was,ceased
R2582	T9937	T9936	acomp	significant,was
R2583	T9938	T9921	punct	.,ceased
R2584	T9940	T9941	amod	Microscopic,examination
R2585	T9941	T9942	nsubj	examination,revealed
R2586	T9943	T9941	prep	of,examination
R2587	T9944	T9945	nmod	P21,testes
R2588	T9945	T9943	pobj	testes,of
R2589	T9946	T9944	cc	and,P21
R2590	T9947	T9944	conj	P42,P21
R2591	T9948	T9949	compound	Dmrt7,mutant
R2592	T9949	T9945	compound	mutant,testes
R2593	T9950	T9951	mark	that,arrest
R2594	T9951	T9942	ccomp	arrest,revealed
R2595	T9952	T9953	compound	germ,cells
R2596	T9953	T9951	nsubj	cells,arrest
R2597	T9954	T9951	prep	in,arrest
R2598	T9955	T9954	pobj	pachynema,in
R2599	T9956	T9951	punct	", ",arrest
R2600	T9957	T9951	cc	and,arrest
R2601	T9958	T9959	amod	later,stages
R2602	T9959	T9960	nsubj	stages,are
R2603	T9960	T9951	conj	are,arrest
R2604	T9961	T9959	prep	of,stages
R2605	T9962	T9963	compound	germ,cells
R2606	T9963	T9961	pobj	cells,of
R2607	T9964	T9965	advmod	largely,missing
R2608	T9965	T9960	acomp	missing,are
R2609	T9966	T9967	punct	(,2C
R2610	T9967	T9942	parataxis	2C,revealed
R2611	T9968	T9967	compound	Figure,2C
R2612	T9969	T9967	cc	and,2C
R2613	T9970	T9967	conj	2D,2C
R2614	T9971	T9967	punct	),2C
R2615	T9972	T9942	punct	.,revealed
R2616	T9974	T9975	compound	Dmrt7,mutant
R2617	T9975	T9976	compound	mutant,mice
R2618	T9976	T9977	nsubj	mice,are
R2619	T9978	T9977	acomp	deficient,are
R2620	T9979	T9977	prep	in,are
R2621	T9980	T9981	amod	postmeiotic,spermatids
R2622	T9981	T9979	pobj	spermatids,in
R2623	T9982	T9977	cc	and,are
R2624	T9983	T9977	conj	lack,are
R2625	T9984	T9985	amod	epididymal,spermatozoa
R2626	T9985	T9983	dobj	spermatozoa,lack
R2627	T9986	T9983	punct	", ",lack
R2628	T9987	T9988	mark	although,develop
R2629	T9988	T9983	advcl	develop,lack
R2630	T9989	T9990	det	a,cells
R2631	T9990	T9988	nsubj	cells,develop
R2632	T9991	T9990	amod	few,cells
R2633	T9992	T9988	prep	to,develop
R2634	T9993	T9994	det	the,stage
R2635	T9994	T9992	pobj	stage,to
R2636	T9995	T9994	amod	round,stage
R2637	T9996	T9994	compound	spermatid,stage
R2638	T9997	T9977	punct	.,are
R2639	T9999	T10000	det	These,defects
R2640	T10000	T10002	nsubj	defects,are
R2641	T10001	T10000	amod	meiotic,defects
R2642	T10003	T10002	prep	in,are
R2643	T10004	T10003	pobj	agreement,in
R2644	T10005	T10004	prep	with,agreement
R2645	T10006	T10007	det	a,analysis
R2646	T10007	T10005	pobj	analysis,with
R2647	T10008	T10007	amod	recent,analysis
R2648	T10009	T10007	amod	preliminary,analysis
R2649	T10010	T10007	prep	of,analysis
R2650	T10011	T10012	det	another,mutation
R2651	T10012	T10010	pobj	mutation,of
R2652	T10013	T10012	compound	Dmrt7,mutation
R2654	T10015	T10002	parataxis	42,are
R2655	T10016	T10015	punct	],42
R2656	T10017	T10002	punct	.,are
R2657	T10019	T10020	mark	While,are
R2658	T10020	T10025	advcl	are,have
R2659	T10021	T10022	det	some,tubules
R2660	T10022	T10020	nsubj	tubules,are
R2661	T10023	T10024	compound	Dmrt7,mutant
R2662	T10024	T10022	compound	mutant,tubules
R2663	T10026	T10027	advmod	highly,vacuolated
R2664	T10027	T10020	acomp	vacuolated,are
R2665	T10028	T10020	cc	and,are
R2666	T10029	T10020	conj	contain,are
R2667	T10030	T10029	advmod	primarily,contain
R2668	T10031	T10032	compound	Sertoli,cells
R2669	T10032	T10029	dobj	cells,contain
R2670	T10033	T10032	cc	and,cells
R2671	T10034	T10032	conj	spermatogonia,cells
R2672	T10035	T10025	punct	", ",have
R2673	T10036	T10025	nsubj	others,have
R2674	T10037	T10038	amod	abundant,spermatocytes
R2675	T10038	T10025	dobj	spermatocytes,have
R2676	T10039	T10038	amod	primary,spermatocytes
R2677	T10040	T10025	punct	.,have
R2678	T10042	T10043	prep	In,contain
R2679	T10044	T10042	pobj	addition,In
R2680	T10045	T10043	punct	", ",contain
R2681	T10046	T10047	det	some,tubules
R2682	T10047	T10043	nsubj	tubules,contain
R2683	T10048	T10049	amod	multinucleated,cells
R2684	T10049	T10043	dobj	cells,contain
R2685	T10050	T10049	cc	and,cells
R2686	T10051	T10049	conj	cells,cells
R2687	T10052	T10051	prep	with,cells
R2688	T10053	T10054	advmod	darkly,stained
R2689	T10054	T10055	amod	stained,nuclei
R2690	T10055	T10052	pobj	nuclei,with
R2691	T10056	T10057	dep	that,are
R2692	T10057	T10055	relcl	are,nuclei
R2693	T10058	T10057	acomp	typical,are
R2694	T10059	T10058	prep	of,typical
R2695	T10060	T10061	amod	apoptotic,cells
R2696	T10061	T10059	pobj	cells,of
R2697	T10062	T10063	punct	(,2D
R2698	T10063	T10043	parataxis	2D,contain
R2699	T10064	T10063	compound	Figure,2D
R2700	T10065	T10063	punct	),2D
R2701	T10066	T10043	punct	.,contain
R2702	T10068	T10069	mark	Since,lack
R2703	T10069	T10073	advcl	lack,used
R2704	T10070	T10071	compound	Dmrt7,testes
R2705	T10071	T10069	nsubj	testes,lack
R2706	T10072	T10071	compound	mutant,testes
R2707	T10074	T10075	advmod	most,cells
R2708	T10075	T10069	dobj	cells,lack
R2709	T10076	T10075	amod	post-pachytene,cells
R2710	T10077	T10073	punct	", ",used
R2711	T10078	T10073	nsubj	we,used
R2712	T10079	T10080	compound	TUNEL,analysis
R2713	T10080	T10073	dobj	analysis,used
R2714	T10081	T10082	aux	to,test
R2715	T10082	T10073	advcl	test,used
R2716	T10083	T10084	mark	whether,eliminated
R2717	T10084	T10082	ccomp	eliminated,test
R2718	T10085	T10086	det	the,cells
R2719	T10086	T10084	nsubjpass	cells,eliminated
R2720	T10087	T10086	amod	missing,cells
R2721	T10088	T10084	auxpass	are,eliminated
R2722	T10089	T10084	prep	by,eliminated
R2723	T10090	T10089	pobj	apoptosis,by
R2724	T10091	T10073	punct	.,used
R2725	T10093	T10094	prep	At,contain
R2726	T10095	T10096	nummod	3,wk
R2727	T10096	T10093	pobj	wk,At
R2728	T10097	T10094	punct	", ",contain
R2729	T10098	T10099	compound	Dmrt7,mutant
R2730	T10099	T10100	compound	mutant,testes
R2731	T10100	T10094	nsubj	testes,contain
R2732	T10101	T10102	advmod	significantly,more
R2733	T10102	T10103	amod	more,cells
R2734	T10103	T10094	dobj	cells,contain
R2735	T10104	T10103	amod	apoptotic,cells
R2736	T10105	T10103	prep	than,cells
R2737	T10106	T10105	pobj	those,than
R2738	T10107	T10106	prep	of,those
R2739	T10108	T10109	amod	wild,type
R2740	T10109	T10111	compound	type,controls
R2741	T10110	T10109	punct	-,type
R2742	T10111	T10107	pobj	controls,of
R2743	T10112	T10094	punct	.,contain
R2744	T10114	T10115	det	The,percentage
R2745	T10115	T10116	nsubj	percentage,was
R2746	T10117	T10115	prep	of,percentage
R2747	T10118	T10119	compound	tubule,sections
R2748	T10119	T10117	pobj	sections,of
R2749	T10120	T10115	prep	with,percentage
R2750	T10121	T10122	nummod	five,nuclei
R2751	T10122	T10120	pobj	nuclei,with
R2752	T10123	T10121	cc	or,five
R2753	T10124	T10121	conj	more,five
R2754	T10125	T10122	amod	apoptotic,nuclei
R2755	T10126	T10127	quantmod	about,three
R2756	T10127	T10128	npadvmod	three,higher
R2757	T10128	T10116	acomp	higher,was
R2758	T10129	T10127	quantmod	times,three
R2759	T10130	T10116	prep	in,was
R2760	T10131	T10132	compound	Dmrt7,mutants
R2761	T10132	T10130	pobj	mutants,in
R2762	T10133	T10116	prep	compared,was
R2763	T10134	T10133	prep	with,compared
R2764	T10135	T10136	amod	wild,type
R2765	T10136	T10134	pobj	type,with
R2766	T10137	T10136	punct	-,type
R2767	T10138	T10139	punct	(,2E
R2768	T10139	T10116	parataxis	2E,was
R2769	T10140	T10141	nummod	20,%
R2770	T10141	T10139	dep	%,2E
R2771	T10142	T10141	cc	versus,%
R2772	T10143	T10144	nummod	7,%
R2773	T10144	T10141	conj	%,%
R2774	T10145	T10139	punct	;,2E
R2775	T10146	T10139	compound	Figure,2E
R2776	T10147	T10139	punct	),2E
R2777	T10148	T10116	punct	.,was
R2778	T10150	T10151	det	A,elevation
R2779	T10151	T10153	nsubj	elevation,was
R2780	T10152	T10151	amod	similar,elevation
R2781	T10154	T10151	prep	of,elevation
R2782	T10155	T10154	pobj	apoptosis,of
R2783	T10156	T10153	acomp	apparent,was
R2784	T10157	T10153	prep	in,was
R2785	T10158	T10159	compound	mutant,testes
R2786	T10159	T10157	pobj	testes,in
R2787	T10160	T10153	prep	at,was
R2788	T10161	T10162	nummod	7,wk
R2789	T10162	T10160	pobj	wk,at
R2790	T10163	T10164	punct	(,2F
R2791	T10164	T10153	parataxis	2F,was
R2792	T10165	T10164	compound	Figure,2F
R2793	T10166	T10164	punct	),2F
R2794	T10167	T10153	punct	.,was
R2795	T10169	T10170	prep	In,were
R2796	T10171	T10169	pobj	mutants,In
R2797	T10172	T10170	punct	", ",were
R2798	T10173	T10174	amod	many,cells
R2799	T10174	T10170	nsubj	cells,were
R2800	T10175	T10174	amod	apoptotic,cells
R2801	T10176	T10170	prep	in,were
R2802	T10177	T10178	det	the,middle
R2803	T10178	T10176	pobj	middle,in
R2804	T10179	T10178	prep	of,middle
R2805	T10180	T10181	det	the,tubules
R2806	T10181	T10179	pobj	tubules,of
R2807	T10182	T10170	punct	", ",were
R2808	T10183	T10184	mark	whereas,occur
R2809	T10184	T10170	advcl	occur,were
R2810	T10185	T10186	det	the,cells
R2811	T10186	T10184	nsubj	cells,occur
R2812	T10187	T10186	amod	apoptotic,cells
R2813	T10188	T10186	prep	in,cells
R2814	T10189	T10190	amod	wild,type
R2815	T10190	T10188	pobj	type,in
R2816	T10191	T10190	punct	-,type
R2817	T10192	T10184	advmod	mainly,occur
R2818	T10193	T10184	prep	near,occur
R2819	T10194	T10195	det	the,periphery
R2820	T10195	T10193	pobj	periphery,near
R2821	T10196	T10195	amod	seminiferous,periphery
R2822	T10197	T10195	compound	tubule,periphery
R2823	T10198	T10170	punct	.,were
R2824	T10200	T10201	det	The,numbers
R2825	T10201	T10202	nsubj	numbers,were
R2826	T10203	T10201	prep	of,numbers
R2827	T10204	T10205	compound	Sertoli,cells
R2828	T10205	T10203	pobj	cells,of
R2829	T10206	T10202	neg	not,were
R2830	T10207	T10208	advmod	significantly,different
R2831	T10208	T10202	acomp	different,were
R2832	T10209	T10208	prep	between,different
R2833	T10210	T10211	amod	wild,type
R2834	T10211	T10213	nmod	type,testes
R2835	T10212	T10211	punct	-,type
R2836	T10213	T10209	pobj	testes,between
R2837	T10214	T10211	cc	and,type
R2838	T10215	T10211	conj	mutant,type
R2839	T10216	T10202	punct	", ",were
R2840	T10217	T10202	cc	and,were
R2841	T10218	T10219	nsubj	we,observed
R2842	T10219	T10202	conj	observed,were
R2843	T10220	T10221	det	no,difference
R2844	T10221	T10219	dobj	difference,observed
R2845	T10222	T10221	prep	in,difference
R2846	T10223	T10224	amod	somatic,apoptosis
R2847	T10224	T10222	pobj	apoptosis,in
R2848	T10225	T10224	compound	cell,apoptosis
R2849	T10226	T10221	prep	in,difference
R2850	T10227	T10226	pobj	mutants,in
R2851	T10228	T10229	punct	(,data
R2852	T10229	T10219	meta	data,observed
R2853	T10230	T10229	amod	unpublished,data
R2854	T10231	T10229	punct	),data
R2855	T10232	T10219	punct	.,observed
R2856	T10234	T10235	prep	From,conclude
R2857	T10236	T10237	det	these,results
R2858	T10237	T10234	pobj	results,From
R2859	T10238	T10235	punct	", ",conclude
R2860	T10239	T10235	nsubj	we,conclude
R2861	T10240	T10241	mark	that,causes
R2862	T10241	T10235	ccomp	causes,conclude
R2863	T10242	T10241	nsubj	loss,causes
R2864	T10243	T10242	prep	of,loss
R2865	T10244	T10243	pobj	Dmrt7,of
R2866	T10245	T10246	det	a,block
R2867	T10246	T10241	dobj	block,causes
R2868	T10247	T10246	prep	in,block
R2869	T10248	T10249	amod	meiotic,progression
R2870	T10249	T10247	pobj	progression,in
R2871	T10250	T10241	punct	", ",causes
R2872	T10251	T10252	advmod	mainly,in
R2873	T10252	T10241	prep	in,causes
R2874	T10253	T10252	pobj	pachynema,in
R2875	T10254	T10241	punct	", ",causes
R2876	T10255	T10241	advcl	leading,causes
R2877	T10256	T10255	prep	to,leading
R2878	T10257	T10258	det	the,elimination
R2879	T10258	T10256	pobj	elimination,to
R2880	T10259	T10258	punct	", ",elimination
R2881	T10260	T10258	prep	by,elimination
R2882	T10261	T10260	pobj	apoptosis,by
R2883	T10262	T10258	punct	", ",elimination
R2884	T10263	T10258	prep	of,elimination
R2885	T10264	T10265	det	the,cells
R2886	T10265	T10263	pobj	cells,of
R2887	T10266	T10265	amod	arrested,cells
R2888	T10267	T10235	punct	.,conclude
R2889	T10945	T10946	compound	Pachytene,Arrest
R2890	T10947	T10946	prep	of,Arrest
R2891	T10948	T10949	compound	Dmrt7,Mutant
R2892	T10949	T10950	compound	Mutant,Cells
R2893	T10950	T10947	pobj	Cells,of
R2894	T10951	T10950	compound	Germ,Cells
R2895	T10953	T10954	aux	To,define
R2896	T10954	T10956	advcl	define,used
R2897	T10955	T10954	advmod	better,define
R2898	T10957	T10958	det	the,stage
R2899	T10958	T10954	dobj	stage,define
R2900	T10959	T10958	amod	spermatogenic,stage
R2901	T10960	T10961	prep	at,arrest
R2902	T10961	T10958	relcl	arrest,stage
R2903	T10962	T10960	pobj	which,at
R2904	T10963	T10964	nmod	Dmrt7,cells
R2905	T10964	T10961	nsubj	cells,arrest
R2906	T10965	T10963	punct	−,Dmrt7
R2907	T10966	T10963	punct	/,Dmrt7
R2908	T10967	T10963	punct	−,Dmrt7
R2909	T10968	T10964	amod	male,cells
R2910	T10969	T10964	compound	germ,cells
R2911	T10970	T10961	cc	and,arrest
R2912	T10971	T10961	conj	die,arrest
R2913	T10972	T10956	punct	", ",used
R2914	T10973	T10956	nsubj	we,used
R2915	T10974	T10956	dobj	antibodies,used
R2916	T10975	T10974	prep	against,antibodies
R2917	T10976	T10977	amod	several,markers
R2918	T10977	T10975	pobj	markers,against
R2919	T10978	T10979	npadvmod	stage,specific
R2920	T10979	T10977	amod	specific,markers
R2921	T10980	T10979	punct	-,specific
R2922	T10981	T10982	compound	germ,cell
R2923	T10982	T10977	compound	cell,markers
R2924	T10983	T10956	punct	.,used
R2925	T10985	T10986	nsubjpass	TRA98,expressed
R2926	T10987	T10986	auxpass	is,expressed
R2927	T10988	T10986	prep	in,expressed
R2928	T10989	T10988	pobj	PGCs,in
R2929	T10990	T10989	cc	and,PGCs
R2930	T10991	T10989	conj	spermatogonia,PGCs
R2931	T10992	T10993	punct	[,43
R2932	T10993	T10986	parataxis	43,expressed
R2933	T10994	T10993	punct	],43
R2934	T10995	T10986	punct	.,expressed
R2935	T10997	T10998	prep	In,form
R2936	T10998	T11012	ccomp	form,were
R2937	T10999	T11000	det	the,testis
R2938	T11000	T10997	pobj	testis,In
R2939	T11001	T11002	amod	wild,type
R2940	T11002	T11000	nmod	type,testis
R2941	T11003	T11002	punct	-,type
R2942	T11004	T11000	amod	adult,testis
R2943	T11005	T10998	punct	", ",form
R2944	T11006	T11007	advmod	strongly,staining
R2945	T11007	T11008	amod	staining,cells
R2946	T11008	T10998	nsubj	cells,form
R2947	T11009	T11010	npadvmod	TRA98,positive
R2948	T11010	T11008	amod	positive,cells
R2949	T11011	T11010	punct	-,positive
R2950	T11013	T11014	det	a,layer
R2951	T11014	T10998	dobj	layer,form
R2952	T11015	T11016	nummod	one,cell
R2953	T11016	T11017	npadvmod	cell,deep
R2954	T11017	T11014	amod	deep,layer
R2955	T11018	T11012	punct	;,were
R2956	T11019	T11012	advmod	however,were
R2957	T11020	T11012	punct	", ",were
R2958	T11021	T11012	prep	in,were
R2959	T11022	T11023	det	the,TRA98
R2960	T11023	T11021	pobj	TRA98,in
R2961	T11024	T11023	compound	mutant,TRA98
R2962	T11025	T11012	punct	", ",were
R2963	T11026	T11027	advmod	strongly,positive
R2964	T11027	T11028	amod	positive,cells
R2965	T11028	T11012	nsubj	cells,were
R2966	T11029	T11030	advmod	abnormally,organized
R2967	T11030	T11012	acomp	organized,were
R2968	T11031	T11012	punct	", ",were
R2969	T11032	T11012	cc	and,were
R2970	T11033	T11034	det	some,tubules
R2971	T11034	T11035	nsubj	tubules,had
R2972	T11035	T11012	conj	had,were
R2973	T11036	T11037	det	a,layer
R2974	T11037	T11035	dobj	layer,had
R2975	T11038	T11039	amod	several,cells
R2976	T11039	T11040	npadvmod	cells,deep
R2977	T11040	T11037	amod	deep,layer
R2978	T11041	T11042	punct	(,3A
R2979	T11042	T11012	parataxis	3A,were
R2980	T11043	T11042	compound	Figure,3A
R2981	T11044	T11042	punct	),3A
R2982	T11045	T11012	punct	.,were
R2983	T11047	T11048	det	The,antibody
R2984	T11048	T11050	nsubj	antibody,recognizes
R2985	T11049	T11048	compound	BC7,antibody
R2986	T11051	T11050	dobj	spermatocytes,recognizes
R2987	T11052	T11050	prep	in,recognizes
R2988	T11053	T11054	det	the,leptotene
R2989	T11054	T11052	pobj	leptotene,in
R2990	T11055	T11050	prep	to,recognizes
R2991	T11056	T11057	amod	early,pachytene
R2992	T11057	T11059	compound	pachytene,stages
R2993	T11058	T11057	punct	-,pachytene
R2994	T11059	T11055	pobj	stages,to
R2995	T11060	T11061	punct	[,44
R2996	T11061	T11050	parataxis	44,recognizes
R2997	T11062	T11061	punct	],44
R2998	T11063	T11050	punct	.,recognizes
R2999	T11065	T11066	compound	Dmrt7,mutant
R3000	T11066	T11067	compound	mutant,testes
R3001	T11067	T11068	nsubj	testes,had
R3002	T11069	T11070	npadvmod	BC7,positive
R3003	T11070	T11072	amod	positive,cells
R3004	T11071	T11070	punct	-,positive
R3005	T11072	T11068	dobj	cells,had
R3006	T11073	T11072	prep	in,cells
R3007	T11074	T11075	advmod	approximately,normal
R3008	T11075	T11076	amod	normal,numbers
R3009	T11076	T11073	pobj	numbers,in
R3010	T11077	T11073	punct	", ",in
R3011	T11078	T11073	cc	but,in
R3012	T11079	T11080	advmod	again,organized
R3013	T11080	T11073	conj	organized,in
R3014	T11081	T11080	advmod	abnormally,organized
R3015	T11082	T11068	punct	", ",had
R3016	T11083	T11068	prep	with,had
R3017	T11084	T11085	amod	many,cells
R3018	T11085	T11083	pobj	cells,with
R3019	T11086	T11085	amod	positive,cells
R3020	T11087	T11085	prep	in,cells
R3021	T11088	T11089	det	the,center
R3022	T11089	T11087	pobj	center,in
R3023	T11090	T11091	advmod	rather,than
R3024	T11091	T11089	cc	than,center
R3025	T11092	T11093	det	the,periphery
R3026	T11093	T11089	conj	periphery,center
R3027	T11094	T11089	prep	of,center
R3028	T11095	T11096	det	the,tubules
R3029	T11096	T11094	pobj	tubules,of
R3030	T11097	T11098	punct	(,3B
R3031	T11098	T11068	parataxis	3B,had
R3032	T11099	T11098	compound	Figure,3B
R3033	T11100	T11098	punct	),3B
R3034	T11101	T11068	punct	.,had
R3035	T11103	T11104	det	The,antibody
R3036	T11104	T11106	nsubj	antibody,recognizes
R3037	T11105	T11104	compound	TRA369,antibody
R3038	T11107	T11108	det	a,protein
R3039	T11108	T11106	dobj	protein,recognizes
R3040	T11109	T11108	compound	calmegin,protein
R3041	T11110	T11108	acl	expressed,protein
R3042	T11111	T11110	prep	in,expressed
R3043	T11112	T11113	compound	pachytene,spermatocytes
R3044	T11113	T11111	pobj	spermatocytes,in
R3045	T11114	T11110	prep	through,expressed
R3046	T11115	T11116	amod	elongated,spermatids
R3047	T11116	T11114	pobj	spermatids,through
R3048	T11117	T11118	punct	[,45
R3049	T11118	T11106	parataxis	45,recognizes
R3050	T11119	T11118	punct	],45
R3051	T11120	T11106	punct	.,recognizes
R3052	T11122	T11123	prep	In,were
R3053	T11124	T11122	pobj	contrast,In
R3054	T11125	T11124	prep	to,contrast
R3055	T11126	T11127	det	the,stages
R3056	T11127	T11125	pobj	stages,to
R3057	T11128	T11127	amod	earlier,stages
R3058	T11129	T11123	punct	", ",were
R3059	T11130	T11131	advmod	far,fewer
R3060	T11131	T11132	amod	fewer,cells
R3061	T11132	T11123	nsubj	cells,were
R3062	T11133	T11134	npadvmod	TRA369,positive
R3063	T11134	T11132	amod	positive,cells
R3064	T11135	T11134	punct	-,positive
R3065	T11136	T11123	acomp	present,were
R3066	T11137	T11136	prep	in,present
R3067	T11138	T11139	compound	mutant,testes
R3068	T11139	T11137	pobj	testes,in
R3069	T11140	T11123	advcl	relative,were
R3070	T11141	T11140	prep	to,relative
R3071	T11142	T11143	amod	wild,type
R3072	T11143	T11141	pobj	type,to
R3073	T11144	T11143	punct	-,type
R3074	T11145	T11146	punct	(,3C
R3075	T11146	T11123	parataxis	3C,were
R3076	T11147	T11146	compound	Figure,3C
R3077	T11148	T11146	punct	),3C
R3078	T11149	T11123	punct	.,were
R3079	T11151	T11152	nsubj	We,quantitated
R3080	T11153	T11152	advmod	also,quantitated
R3081	T11154	T11155	det	the,number
R3082	T11155	T11152	dobj	number,quantitated
R3083	T11156	T11155	prep	of,number
R3084	T11157	T11156	pobj	cells,of
R3085	T11158	T11155	prep	at,number
R3086	T11159	T11160	det	each,stage
R3087	T11160	T11158	pobj	stage,at
R3088	T11161	T11160	amod	meiotic,stage
R3089	T11162	T11152	advcl	using,quantitated
R3090	T11163	T11164	compound	spermatocyte,spreads
R3091	T11164	T11162	dobj	spreads,using
R3092	T11165	T11152	punct	", ",quantitated
R3093	T11166	T11152	advcl	assaying,quantitated
R3094	T11167	T11168	npadvmod	chromosome,pairing
R3095	T11168	T11170	amod	pairing,status
R3096	T11169	T11168	punct	-,pairing
R3097	T11170	T11166	dobj	status,assaying
R3098	T11171	T11166	prep	by,assaying
R3099	T11172	T11171	pcomp	staining,by
R3100	T11173	T11172	prep	for,staining
R3101	T11174	T11173	pobj	SYCP3,for
R3102	T11175	T11174	punct	", ",SYCP3
R3103	T11176	T11177	det	a,component
R3104	T11177	T11174	appos	component,SYCP3
R3105	T11178	T11177	prep	of,component
R3106	T11179	T11180	det	the,complex
R3107	T11180	T11178	pobj	complex,of
R3108	T11181	T11180	amod	synaptonemal,complex
R3109	T11182	T11183	punct	(,Figure
R3110	T11183	T11152	parataxis	Figure,quantitated
R3111	T11184	T11183	nummod	4,Figure
R3112	T11185	T11183	punct	),Figure
R3113	T11186	T11152	punct	.,quantitated
R3114	T11188	T11189	nsubj	We,found
R3115	T11190	T11191	mark	that,accumulate
R3116	T11191	T11189	ccomp	accumulate,found
R3117	T11192	T11193	compound	Dmrt7,mutants
R3118	T11193	T11191	nsubj	mutants,accumulate
R3119	T11194	T11195	compound	pachytene,cells
R3120	T11195	T11191	dobj	cells,accumulate
R3121	T11196	T11191	cc	but,accumulate
R3122	T11197	T11191	conj	have,accumulate
R3123	T11198	T11199	advmod	greatly,reduced
R3124	T11199	T11200	amod	reduced,numbers
R3125	T11200	T11197	dobj	numbers,have
R3126	T11201	T11200	prep	of,numbers
R3127	T11202	T11201	pobj	cells,of
R3128	T11203	T11197	prep	in,have
R3129	T11204	T11205	amod	late,pachynema
R3130	T11205	T11203	pobj	pachynema,in
R3131	T11206	T11205	punct	-,pachynema
R3132	T11207	T11203	cc	and,in
R3133	T11208	T11203	conj	beyond,in
R3134	T11209	T11189	punct	.,found
R3135	T11211	T11212	advmod	Together,confirm
R3136	T11213	T11212	punct	", ",confirm
R3137	T11214	T11215	det	these,results
R3138	T11215	T11212	nsubj	results,confirm
R3139	T11216	T11217	mark	that,occurs
R3140	T11217	T11212	ccomp	occurs,confirm
R3141	T11218	T11219	det	the,arrest
R3142	T11219	T11217	nsubj	arrest,occurs
R3143	T11220	T11219	amod	meiotic,arrest
R3144	T11221	T11219	prep	in,arrest
R3145	T11222	T11223	compound	Dmrt7,mutants
R3146	T11223	T11221	pobj	mutants,in
R3147	T11224	T11217	advmod	primarily,occurs
R3148	T11225	T11217	prep	during,occurs
R3149	T11226	T11225	pobj	pachynema,during
R3150	T11227	T11217	cc	and,occurs
R3151	T11228	T11217	conj	results,occurs
R3152	T11229	T11228	prep	in,results
R3153	T11230	T11231	amod	efficient,elimination
R3154	T11231	T11229	pobj	elimination,in
R3155	T11232	T11231	prep	of,elimination
R3156	T11233	T11234	amod	arrested,cells
R3157	T11234	T11232	pobj	cells,of
R3158	T11235	T11212	punct	.,confirm
R3159	T11774	T11775	amod	Normal,Prophase
R3160	T11776	T11775	amod	Meiotic,Prophase
R3161	T11777	T11775	prep	in,Prophase
R3162	T11778	T11779	compound	Dmrt7,Mutant
R3163	T11779	T11780	compound	Mutant,Cells
R3164	T11780	T11777	pobj	Cells,in
R3165	T11781	T11780	compound	Germ,Cells
R3166	T11783	T11784	nsubj	Defects,trigger
R3167	T11785	T11783	prep	in,Defects
R3168	T11786	T11787	compound	chromosome,pairing
R3169	T11787	T11785	pobj	pairing,in
R3170	T11788	T11787	punct	", ",pairing
R3171	T11789	T11787	conj	synapsis,pairing
R3172	T11790	T11789	punct	", ",synapsis
R3173	T11791	T11789	cc	or,synapsis
R3174	T11792	T11789	conj	recombination,synapsis
R3175	T11793	T11784	aux	can,trigger
R3176	T11794	T11795	compound	pachytene,arrest
R3177	T11795	T11784	dobj	arrest,trigger
R3178	T11796	T11795	cc	and,arrest
R3179	T11797	T11795	conj	apoptosis,arrest
R3180	T11798	T11799	punct	[,46
R3181	T11799	T11784	parataxis	46,trigger
R3182	T11800	T11799	punct	],46
R3183	T11801	T11784	punct	.,trigger
R3184	T11803	T11804	nsubj	We,examined
R3185	T11805	T11804	advmod	therefore,examined
R3186	T11806	T11807	det	these,events
R3187	T11807	T11804	dobj	events,examined
R3188	T11808	T11804	prep	in,examined
R3189	T11809	T11810	compound	Dmrt7,mutant
R3190	T11810	T11811	compound	mutant,testes
R3191	T11811	T11808	pobj	testes,in
R3192	T11812	T11804	punct	.,examined
R3193	T11814	T11815	aux	To,assess
R3194	T11815	T11816	advcl	assess,used
R3195	T11817	T11818	compound	homolog,synapsis
R3196	T11818	T11815	dobj	synapsis,assess
R3197	T11819	T11816	punct	", ",used
R3198	T11820	T11816	nsubj	we,used
R3199	T11821	T11816	dobj	antibodies,used
R3200	T11822	T11821	prep	to,antibodies
R3201	T11823	T11822	pobj	SYCP1,to
R3202	T11824	T11823	punct	", ",SYCP1
R3203	T11825	T11826	det	a,component
R3204	T11826	T11823	appos	component,SYCP1
R3205	T11827	T11826	amod	synaptonemal,component
R3206	T11828	T11826	compound	complex,component
R3207	T11829	T11826	compound	transverse,component
R3208	T11830	T11826	compound	element,component
R3209	T11831	T11821	punct	", ",antibodies
R3210	T11832	T11821	cc	and,antibodies
R3211	T11833	T11821	conj	SYCP3,antibodies
R3212	T11834	T11833	punct	", ",SYCP3
R3213	T11835	T11836	det	a,component
R3214	T11836	T11833	appos	component,SYCP3
R3215	T11837	T11836	prep	of,component
R3216	T11838	T11839	det	the,element
R3217	T11839	T11837	pobj	element,of
R3218	T11840	T11839	amod	axial,element
R3219	T11841	T11836	punct	", ",component
R3220	T11842	T11843	dep	which,remains
R3221	T11843	T11836	relcl	remains,component
R3222	T11844	T11843	prep	on,remains
R3223	T11845	T11846	det	the,axes
R3224	T11846	T11844	pobj	axes,on
R3225	T11847	T11846	amod	desynapsed,axes
R3226	T11848	T11843	prep	during,remains
R3227	T11849	T11848	pobj	diplonema,during
R3228	T11850	T11851	punct	[,48
R3229	T11851	T11816	parataxis	48,used
R3230	T11852	T11851	nummod	47,48
R3231	T11853	T11851	punct	",",48
R3232	T11854	T11851	punct	],48
R3233	T11855	T11816	punct	.,used
R3234	T11857	T11858	nsubj	Formation,was
R3235	T11859	T11857	prep	of,Formation
R3236	T11860	T11861	amod	synaptonemal,complexes
R3237	T11861	T11859	pobj	complexes,of
R3238	T11862	T11857	prep	in,Formation
R3239	T11863	T11864	det	the,mutant
R3240	T11864	T11862	pobj	mutant,in
R3241	T11865	T11858	acomp	indistinguishable,was
R3242	T11866	T11865	prep	from,indistinguishable
R3243	T11867	T11866	pobj	that,from
R3244	T11868	T11867	prep	in,that
R3245	T11869	T11870	amod	wild,type
R3246	T11870	T11868	pobj	type,in
R3247	T11871	T11870	punct	-,type
R3248	T11872	T11858	punct	", ",was
R3249	T11873	T11874	mark	as,indicated
R3250	T11874	T11858	advcl	indicated,was
R3251	T11875	T11874	prep	by,indicated
R3252	T11876	T11877	det	the,accumulation
R3253	T11877	T11875	pobj	accumulation,by
R3254	T11878	T11877	amod	proper,accumulation
R3255	T11879	T11877	prep	of,accumulation
R3256	T11880	T11879	pobj	SYCP1,of
R3257	T11881	T11882	punct	(,data
R3258	T11882	T11880	parataxis	data,SYCP1
R3259	T11883	T11882	amod	unpublished,data
R3260	T11884	T11882	punct	),data
R3261	T11885	T11880	cc	and,SYCP1
R3262	T11886	T11880	conj	SYCP3,SYCP1
R3263	T11887	T11888	punct	(,5A
R3264	T11888	T11858	parataxis	5A,was
R3265	T11889	T11888	compound	Figure,5A
R3266	T11890	T11888	punct	),5A
R3267	T11891	T11858	punct	.,was
R3268	T11893	T11894	advmod	Likewise,showed
R3269	T11895	T11894	punct	", ",showed
R3270	T11896	T11897	det	the,spermatocytes
R3271	T11897	T11894	nsubj	spermatocytes,showed
R3272	T11898	T11899	compound	Dmrt7,mutant
R3273	T11899	T11897	compound	mutant,spermatocytes
R3274	T11900	T11897	compound	zygotene,spermatocytes
R3275	T11901	T11902	amod	normal,accumulation
R3276	T11902	T11894	dobj	accumulation,showed
R3277	T11903	T11902	prep	of,accumulation
R3278	T11904	T11905	det	the,RAD51
R3279	T11905	T11903	pobj	RAD51,of
R3280	T11906	T11905	amod	early,RAD51
R3281	T11907	T11905	compound	recombination,RAD51
R3282	T11908	T11909	compound	repair,marker
R3283	T11909	T11905	compound	marker,RAD51
R3284	T11910	T11894	punct	", ",showed
R3285	T11911	T11894	advcl	suggesting,showed
R3286	T11912	T11913	mark	that,affected
R3287	T11913	T11911	ccomp	affected,suggesting
R3288	T11914	T11915	amod	early,recombination
R3289	T11915	T11913	nsubjpass	recombination,affected
R3290	T11916	T11915	amod	meiotic,recombination
R3291	T11917	T11913	auxpass	is,affected
R3292	T11918	T11913	neg	not,affected
R3293	T11919	T11913	advmod	significantly,affected
R3294	T11920	T11921	punct	(,5B
R3295	T11921	T11894	parataxis	5B,showed
R3296	T11922	T11921	compound	Figure,5B
R3297	T11923	T11921	punct	),5B
R3298	T11924	T11894	punct	.,showed
R3299	T11926	T11927	compound	Dmrt7,mutant
R3300	T11927	T11928	compound	mutant,spermatocytes
R3301	T11928	T11929	nsubj	spermatocytes,exhibited
R3302	T11930	T11931	det	the,decline
R3303	T11931	T11929	dobj	decline,exhibited
R3304	T11932	T11931	amod	expected,decline
R3305	T11933	T11931	prep	in,decline
R3306	T11934	T11935	det	the,presence
R3307	T11935	T11933	pobj	presence,in
R3308	T11936	T11935	prep	of,presence
R3309	T11937	T11938	compound	RAD51,foci
R3310	T11938	T11936	pobj	foci,of
R3311	T11939	T11931	acl	associated,decline
R3312	T11940	T11939	prep	with,associated
R3313	T11941	T11942	det	the,complexes
R3314	T11942	T11940	pobj	complexes,with
R3315	T11943	T11942	amod	autosomal,complexes
R3316	T11944	T11942	amod	synaptonemal,complexes
R3317	T11945	T11946	punct	(,data
R3318	T11946	T11929	parataxis	data,exhibited
R3319	T11947	T11948	compound	Figure,5B
R3320	T11948	T11946	dep	5B,data
R3321	T11949	T11946	punct	;,data
R3322	T11950	T11946	amod	unpublished,data
R3323	T11951	T11946	punct	),data
R3324	T11952	T11953	punct	[,49
R3325	T11953	T11929	parataxis	49,exhibited
R3326	T11954	T11953	punct	],49
R3327	T11955	T11929	punct	.,exhibited
R3328	T11957	T11958	det	The,cells
R3329	T11958	T11961	nsubj	cells,underwent
R3330	T11959	T11958	amod	few,cells
R3331	T11960	T11958	amod	surviving,cells
R3332	T11962	T11963	dep	that,progressed
R3333	T11963	T11958	relcl	progressed,cells
R3334	T11964	T11963	prep	beyond,progressed
R3335	T11965	T11964	pobj	pachynema,beyond
R3336	T11966	T11961	advmod	also,underwent
R3337	T11967	T11968	advmod	apparently,normal
R3338	T11968	T11969	amod	normal,desynapsis
R3339	T11969	T11961	dobj	desynapsis,underwent
R3340	T11970	T11961	prep	during,underwent
R3341	T11971	T11970	pobj	diplonema,during
R3342	T11972	T11973	punct	(,5A
R3343	T11973	T11961	parataxis	5A,underwent
R3344	T11974	T11973	compound	Figure,5A
R3345	T11975	T11973	punct	),5A
R3346	T11976	T11961	punct	.,underwent
R3347	T11978	T11979	prep	From,conclude
R3348	T11980	T11981	det	these,results
R3349	T11981	T11978	pobj	results,From
R3350	T11982	T11979	punct	", ",conclude
R3351	T11983	T11979	nsubj	we,conclude
R3352	T11984	T11985	mark	that,are
R3353	T11985	T11979	ccomp	are,conclude
R3354	T11986	T11987	amod	chromosomal,pairing
R3355	T11987	T11985	nsubj	pairing,are
R3356	T11988	T11987	punct	", ",pairing
R3357	T11989	T11987	conj	synapsis,pairing
R3358	T11990	T11989	punct	", ",synapsis
R3359	T11991	T11989	conj	recombination,synapsis
R3360	T11992	T11991	punct	", ",recombination
R3361	T11993	T11991	cc	and,recombination
R3362	T11994	T11991	conj	desynapsis,recombination
R3363	T11995	T11987	prep	during,pairing
R3364	T11996	T11995	pobj	prophase,during
R3365	T11997	T11996	nummod	I,prophase
R3366	T11998	T11987	prep	in,pairing
R3367	T11999	T12000	compound	Dmrt7,mutant
R3368	T12000	T12001	compound	mutant,males
R3369	T12001	T11998	pobj	males,in
R3370	T12002	T12003	advmod	grossly,normal
R3371	T12003	T11985	acomp	normal,are
R3372	T12004	T11979	punct	.,conclude
R3375	T13075	T13076	amod	Abnormal,Organization
R3376	T13077	T13076	amod	Cellular,Organization
R3377	T13078	T13076	cc	and,Organization
R3378	T13079	T13080	det	the,Role
R3379	T13080	T13076	conj	Role,Organization
R3380	T13081	T13080	prep	of,Role
R3381	T13082	T13083	compound	Sertoli,Cells
R3382	T13083	T13081	pobj	Cells,of
R3383	T13085	T13086	compound	Sertoli,cells
R3384	T13086	T13087	nsubj	cells,interact
R3385	T13088	T13087	prep	with,interact
R3386	T13089	T13090	compound	germ,cells
R3387	T13090	T13088	pobj	cells,with
R3388	T13091	T13087	prep	during,interact
R3389	T13092	T13091	pobj	spermatogenesis,during
R3390	T13093	T13087	cc	and,interact
R3391	T13094	T13095	det	the,interaction
R3392	T13095	T13096	nsubj	interaction,is
R3393	T13096	T13087	conj	is,interact
R3394	T13097	T13096	acomp	critical,is
R3395	T13098	T13097	prep	for,critical
R3396	T13099	T13100	compound	germ,cell
R3397	T13100	T13101	compound	cell,maturation
R3398	T13101	T13098	pobj	maturation,for
R3399	T13102	T13103	punct	[,50
R3400	T13103	T13096	parataxis	50,is
R3401	T13104	T13103	punct	],50
R3402	T13105	T13096	punct	.,is
R3403	T13107	T13108	mark	Although,detect
R3404	T13108	T13112	advcl	detect,considered
R3405	T13109	T13108	nsubj	we,detect
R3406	T13110	T13108	aux	did,detect
R3407	T13111	T13108	neg	not,detect
R3408	T13113	T13114	compound	DMRT7,expression
R3409	T13114	T13108	dobj	expression,detect
R3410	T13115	T13108	prep	in,detect
R3411	T13116	T13117	compound	Sertoli,cells
R3412	T13117	T13115	pobj	cells,in
R3413	T13118	T13108	prep	by,detect
R3414	T13119	T13120	compound	antibody,staining
R3415	T13120	T13118	pobj	staining,by
R3416	T13121	T13112	punct	", ",considered
R3417	T13122	T13112	nsubj	we,considered
R3418	T13123	T13112	advmod	nevertheless,considered
R3419	T13124	T13125	det	the,possibility
R3420	T13125	T13112	dobj	possibility,considered
R3421	T13126	T13127	mark	that,contribute
R3422	T13127	T13125	acl	contribute,possibility
R3423	T13128	T13129	compound	Sertoli,cell
R3424	T13129	T13130	compound	cell,defects
R3425	T13130	T13127	nsubj	defects,contribute
R3426	T13131	T13127	aux	might,contribute
R3427	T13132	T13127	prep	to,contribute
R3428	T13133	T13134	det	the,failure
R3429	T13134	T13132	pobj	failure,to
R3430	T13135	T13136	amod	male,specific
R3431	T13136	T13134	amod	specific,failure
R3432	T13137	T13136	punct	-,specific
R3433	T13138	T13139	compound	germ,line
R3434	T13139	T13134	compound	line,failure
R3435	T13140	T13134	prep	of,failure
R3436	T13141	T13142	compound	Dmrt7,mutants
R3437	T13142	T13140	pobj	mutants,of
R3438	T13143	T13112	punct	.,considered
R3439	T13145	T13146	aux	To,characterize
R3440	T13146	T13147	advcl	characterize,examined
R3441	T13148	T13149	compound	Sertoli,cell
R3442	T13149	T13150	compound	cell,differentiation
R3443	T13150	T13146	dobj	differentiation,characterize
R3444	T13151	T13147	punct	", ",examined
R3445	T13152	T13147	nsubj	we,examined
R3446	T13153	T13147	dobj	expression,examined
R3447	T13154	T13153	prep	of,expression
R3448	T13155	T13156	det	the,markers
R3449	T13156	T13154	pobj	markers,of
R3450	T13157	T13158	compound	Sertoli,cell
R3451	T13158	T13156	compound	cell,markers
R3452	T13159	T13156	appos	GATA4,markers
R3453	T13160	T13159	punct	(,GATA4
R3454	T13161	T13162	det	a,marker
R3455	T13162	T13159	appos	marker,GATA4
R3456	T13163	T13162	prep	of,marker
R3457	T13164	T13165	amod	immature,cells
R3458	T13165	T13163	pobj	cells,of
R3459	T13166	T13165	amod	postnatal,cells
R3460	T13167	T13165	compound	Sertoli,cells
R3461	T13168	T13159	punct	),GATA4
R3462	T13169	T13159	cc	and,GATA4
R3463	T13170	T13159	conj	GATA1,GATA4
R3464	T13171	T13170	punct	(,GATA1
R3465	T13172	T13173	det	a,marker
R3466	T13173	T13170	appos	marker,GATA1
R3467	T13174	T13173	amod	mature,marker
R3468	T13175	T13176	compound	Sertoli,cell
R3469	T13176	T13173	compound	cell,marker
R3470	T13177	T13170	punct	),GATA1
R3471	T13178	T13147	punct	.,examined
R3472	T13180	T13181	det	The,levels
R3473	T13181	T13182	nsubj	levels,appeared
R3474	T13183	T13181	prep	of,levels
R3475	T13184	T13185	det	these,proteins
R3476	T13185	T13183	pobj	proteins,of
R3477	T13186	T13182	oprd	normal,appeared
R3478	T13187	T13182	advcl	relative,appeared
R3479	T13188	T13187	prep	to,relative
R3480	T13189	T13190	amod	wild,type
R3481	T13190	T13188	pobj	type,to
R3482	T13191	T13190	punct	-,type
R3483	T13192	T13190	prep	at,type
R3484	T13193	T13192	pobj	P14,at
R3485	T13194	T13193	cc	and,P14
R3486	T13195	T13193	conj	P42,P14
R3487	T13196	T13197	punct	(,6A
R3488	T13197	T13182	parataxis	6A,appeared
R3489	T13198	T13197	compound	Figure,6A
R3490	T13199	T13200	punct	–,6C
R3491	T13200	T13197	prep	6C,6A
R3492	T13201	T13197	punct	),6A
R3493	T13202	T13182	punct	", ",appeared
R3494	T13203	T13204	mark	as,did
R3495	T13204	T13182	advcl	did,appeared
R3496	T13205	T13206	det	the,receptor
R3497	T13206	T13204	nsubj	receptor,did
R3498	T13207	T13206	compound	androgen,receptor
R3499	T13208	T13209	punct	(,data
R3500	T13209	T13206	parataxis	data,receptor
R3501	T13210	T13211	compound	Figure,S3
R3502	T13211	T13209	dep	S3,data
R3503	T13212	T13209	punct	;,data
R3504	T13213	T13209	amod	unpublished,data
R3505	T13214	T13209	punct	),data
R3506	T13215	T13182	punct	.,appeared
R3507	T13217	T13218	advmod	However,was
R3508	T13218	T13229	ccomp	was,displaced
R3509	T13219	T13218	punct	", ",was
R3510	T13220	T13221	det	the,organization
R3511	T13221	T13218	nsubj	organization,was
R3512	T13222	T13221	prep	of,organization
R3513	T13223	T13224	compound	Sertoli,cells
R3514	T13224	T13222	pobj	cells,of
R3515	T13225	T13221	prep	in,organization
R3516	T13226	T13227	compound	Dmrt7,testes
R3517	T13227	T13225	pobj	testes,in
R3518	T13228	T13227	compound	mutant,testes
R3519	T13230	T13218	acomp	abnormal,was
R3520	T13231	T13229	punct	: ,displaced
R3521	T13232	T13229	prep	in,displaced
R3522	T13233	T13234	det	some,tubules
R3523	T13234	T13232	pobj	tubules,in
R3524	T13235	T13236	npadvmod	GATA1,positive
R3525	T13236	T13238	amod	positive,nuclei
R3526	T13237	T13236	punct	-,positive
R3527	T13238	T13229	nsubjpass	nuclei,displaced
R3528	T13239	T13240	compound	Sertoli,cell
R3529	T13240	T13238	compound	cell,nuclei
R3530	T13241	T13229	auxpass	were,displaced
R3531	T13242	T13229	prep	from,displaced
R3532	T13243	T13244	poss	their,apposition
R3533	T13244	T13242	pobj	apposition,from
R3534	T13245	T13244	amod	usual,apposition
R3535	T13246	T13244	amod	close,apposition
R3536	T13247	T13244	prep	with,apposition
R3537	T13248	T13249	det	the,membrane
R3538	T13249	T13247	pobj	membrane,with
R3539	T13250	T13249	compound	basement,membrane
R3540	T13251	T13252	punct	(,6C
R3541	T13252	T13229	parataxis	6C,displaced
R3542	T13253	T13252	compound	Figure,6C
R3543	T13254	T13252	punct	),6C
R3544	T13255	T13229	punct	.,displaced
R3545	T13257	T13258	prep	In,packed
R3546	T13259	T13260	amod	such,tubules
R3547	T13260	T13257	pobj	tubules,In
R3548	T13261	T13258	punct	", ",packed
R3549	T13262	T13258	nsubjpass	nuclei,packed
R3550	T13263	T13262	prep	of,nuclei
R3551	T13264	T13265	amod	pre-meiotic,cells
R3552	T13265	T13263	pobj	cells,of
R3553	T13266	T13265	compound	germ,cells
R3554	T13267	T13265	cc	and,cells
R3555	T13268	T13265	conj	spermatocytes,cells
R3556	T13269	T13258	auxpass	were,packed
R3557	T13270	T13258	advmod	close,packed
R3558	T13271	T13270	prep	to,close
R3559	T13272	T13273	det	the,membrane
R3560	T13273	T13271	pobj	membrane,to
R3561	T13274	T13273	amod	basal,membrane
R3563	T13276	T13277	amod	few,cells
R3564	T13277	T13279	nsubjpass	cells,found
R3565	T13278	T13277	compound	germ,cells
R3566	T13279	T13258	conj	found,packed
R3567	T13280	T13279	auxpass	were,found
R3568	T13281	T13279	prep	in,found
R3569	T13282	T13283	det	the,region
R3570	T13283	T13281	pobj	region,in
R3571	T13284	T13283	amod	adlumenal,region
R3572	T13285	T13279	punct	.,found
R3573	T13287	T13288	det	The,organization
R3574	T13288	T13292	nsubj	organization,raised
R3575	T13289	T13288	amod	aberrant,organization
R3576	T13290	T13291	compound	Sertoli,cell
R3577	T13291	T13288	compound	cell,organization
R3578	T13293	T13288	prep	in,organization
R3579	T13294	T13295	compound	Dmrt7,testes
R3580	T13295	T13293	pobj	testes,in
R3581	T13296	T13295	compound	mutant,testes
R3582	T13297	T13298	det	the,possibility
R3583	T13298	T13292	dobj	possibility,raised
R3584	T13299	T13300	mark	that,result
R3585	T13300	T13298	acl	result,possibility
R3586	T13301	T13302	det	the,phenotype
R3587	T13302	T13300	nsubj	phenotype,result
R3588	T13303	T13304	compound	germ,cell
R3589	T13304	T13302	compound	cell,phenotype
R3590	T13305	T13300	aux	might,result
R3591	T13306	T13300	advmod	indirectly,result
R3592	T13307	T13300	prep	from,result
R3593	T13308	T13307	pobj	defects,from
R3594	T13309	T13308	prep	in,defects
R3595	T13310	T13311	compound	Sertoli,cell
R3596	T13311	T13312	compound	cell,function
R3597	T13312	T13309	pobj	function,in
R3598	T13313	T13292	punct	.,raised
R3599	T13315	T13316	aux	To,test
R3600	T13316	T13317	advcl	test,deleted
R3601	T13318	T13319	det	this,possibility
R3602	T13319	T13316	dobj	possibility,test
R3603	T13320	T13317	punct	", ",deleted
R3604	T13321	T13317	nsubj	we,deleted
R3605	T13322	T13317	dobj	Dmrt7,deleted
R3606	T13323	T13317	advmod	just,deleted
R3607	T13324	T13317	prep	in,deleted
R3608	T13325	T13326	det	the,lineage
R3609	T13326	T13324	pobj	lineage,in
R3610	T13327	T13328	compound	Sertoli,cell
R3611	T13328	T13326	compound	cell,lineage
R3612	T13329	T13317	prep	by,deleted
R3613	T13330	T13329	pcomp	crossing,by
R3614	T13331	T13330	dobj	mice,crossing
R3615	T13332	T13331	acl	carrying,mice
R3616	T13333	T13334	det	the,allele
R3617	T13334	T13332	dobj	allele,carrying
R3618	T13335	T13334	amod	floxed,allele
R3619	T13336	T13334	compound	Dmrt7,allele
R3620	T13337	T13330	prep	with,crossing
R3621	T13338	T13339	compound	Dhh,Cre
R3622	T13339	T13341	npadvmod	Cre,transgenic
R3623	T13340	T13339	punct	-,Cre
R3624	T13341	T13342	amod	transgenic,mice
R3625	T13342	T13337	pobj	mice,with
R3626	T13343	T13344	punct	[,51
R3627	T13344	T13317	parataxis	51,deleted
R3628	T13345	T13344	punct	],51
R3629	T13346	T13317	punct	.,deleted
R3630	T13348	T13349	det	The,promoter
R3631	T13349	T13355	nsubj	promoter,is
R3632	T13350	T13351	nmod	Desert,hedgehog
R3633	T13351	T13349	nmod	hedgehog,promoter
R3634	T13352	T13351	punct	(,hedgehog
R3635	T13353	T13351	appos	Dhh,hedgehog
R3636	T13354	T13349	punct	),promoter
R3637	T13356	T13355	attr	active,is
R3638	T13357	T13355	advcl	starting,is
R3639	T13358	T13357	prep	at,starting
R3640	T13359	T13358	prep	about,at
R3641	T13360	T13359	pobj	E12.5,about
R3642	T13361	T13357	prep	in,starting
R3643	T13362	T13363	amod	pre-Sertoli,cells
R3644	T13363	T13361	pobj	cells,in
R3645	T13364	T13361	cc	but,in
R3646	T13365	T13364	neg	not,but
R3647	T13366	T13361	conj	in,in
R3648	T13367	T13368	compound	germ,cells
R3649	T13368	T13366	pobj	cells,in
R3650	T13369	T13355	punct	", ",is
R3651	T13370	T13355	advcl	allowing,is
R3652	T13371	T13370	dobj	deletion,allowing
R3653	T13372	T13371	prep	of,deletion
R3654	T13373	T13372	pobj	Dmrt7,of
R3655	T13374	T13371	prep	in,deletion
R3656	T13375	T13376	compound	Sertoli,cells
R3657	T13376	T13374	pobj	cells,in
R3658	T13377	T13378	advmod	well,before
R3659	T13378	T13370	prep	before,allowing
R3660	T13379	T13380	det	any,requirement
R3661	T13380	T13378	pobj	requirement,before
R3662	T13381	T13380	amod	likely,requirement
R3663	T13382	T13380	prep	for,requirement
R3664	T13383	T13384	poss	its,function
R3665	T13384	T13382	pobj	function,for
R3666	T13385	T13386	punct	[,52
R3667	T13386	T13355	parataxis	52,is
R3668	T13387	T13386	punct	],52
R3669	T13388	T13355	punct	.,is
R3670	T13390	T13391	amod	Testicular,size
R3671	T13391	T13392	nsubjpass	size,reduced
R3672	T13393	T13391	prep	in,size
R3673	T13394	T13395	npadvmod	Sertoli,targeted
R3674	T13395	T13397	amod	targeted,animals
R3675	T13396	T13395	punct	-,targeted
R3676	T13397	T13393	pobj	animals,in
R3677	T13398	T13399	punct	(,Dmrt7KO
R3678	T13399	T13397	parataxis	Dmrt7KO,animals
R3679	T13400	T13399	compound	SC,Dmrt7KO
R3680	T13401	T13399	punct	-,Dmrt7KO
R3681	T13402	T13399	punct	),Dmrt7KO
R3682	T13403	T13392	auxpass	was,reduced
R3683	T13404	T13392	advmod	slightly,reduced
R3684	T13405	T13392	prep	from,reduced
R3685	T13406	T13405	pobj	that,from
R3686	T13407	T13406	prep	of,that
R3687	T13408	T13409	amod	wild,type
R3688	T13409	T13407	pobj	type,of
R3689	T13410	T13409	punct	-,type
R3690	T13411	T13392	punct	", ",reduced
R3691	T13412	T13392	cc	but,reduced
R3692	T13413	T13414	amod	histological,analysis
R3693	T13414	T13415	nsubj	analysis,revealed
R3694	T13415	T13392	conj	revealed,reduced
R3695	T13416	T13417	det	no,difference
R3696	T13417	T13415	dobj	difference,revealed
R3697	T13418	T13417	amod	obvious,difference
R3698	T13419	T13417	prep	between,difference
R3699	T13420	T13421	amod	wild,type
R3700	T13421	T13423	nmod	type,testes
R3701	T13422	T13421	punct	-,type
R3702	T13423	T13419	pobj	testes,between
R3703	T13424	T13421	cc	and,type
R3704	T13425	T13426	compound	SC,Dmrt7KO
R3705	T13426	T13421	conj	Dmrt7KO,type
R3706	T13427	T13426	punct	-,Dmrt7KO
R3707	T13428	T13429	punct	(,6D
R3708	T13429	T13415	parataxis	6D,revealed
R3709	T13430	T13429	compound	Figure,6D
R3710	T13431	T13429	punct	),6D
R3711	T13432	T13415	punct	.,revealed
R3712	T13434	T13435	nsubj	Spermatogenesis,appeared
R3713	T13436	T13435	oprd	normal,appeared
R3714	T13437	T13435	punct	", ",appeared
R3715	T13438	T13439	amod	mature,sperm
R3716	T13439	T13440	nsubj	sperm,were
R3717	T13440	T13435	conj	were,appeared
R3718	T13441	T13440	acomp	present,were
R3719	T13442	T13440	punct	", ",were
R3720	T13443	T13440	cc	and,were
R3721	T13444	T13445	compound	SC,Dmrt7KO
R3722	T13445	T13447	compound	Dmrt7KO,mice
R3723	T13446	T13445	punct	-,Dmrt7KO
R3724	T13447	T13448	nsubj	mice,were
R3725	T13448	T13440	conj	were,were
R3726	T13449	T13448	acomp	fertile,were
R3727	T13450	T13448	punct	.,were
R3728	T13452	T13453	prep	In,showed
R3729	T13454	T13452	pobj	addition,In
R3730	T13455	T13453	punct	", ",showed
R3731	T13456	T13457	compound	GATA1,staining
R3732	T13457	T13453	nsubj	staining,showed
R3733	T13458	T13459	mark	that,located
R3734	T13459	T13453	ccomp	located,showed
R3735	T13460	T13461	compound	Sertoli,cell
R3736	T13461	T13462	compound	cell,nuclei
R3737	T13462	T13459	nsubjpass	nuclei,located
R3738	T13463	T13459	auxpass	were,located
R3739	T13464	T13459	advcl	adjacent,located
R3740	T13465	T13464	prep	to,adjacent
R3741	T13466	T13467	det	the,membrane
R3742	T13467	T13465	pobj	membrane,to
R3743	T13468	T13467	compound	basement,membrane
R3744	T13469	T13459	prep	as,located
R3745	T13470	T13469	prep	in,as
R3746	T13471	T13472	amod	wild,type
R3747	T13472	T13470	pobj	type,in
R3748	T13473	T13472	punct	-,type
R3749	T13474	T13475	punct	(,6E
R3750	T13475	T13453	parataxis	6E,showed
R3751	T13476	T13475	compound	Figure,6E
R3752	T13477	T13475	punct	),6E
R3753	T13478	T13453	punct	.,showed
R3754	T13480	T13481	det	These,results
R3755	T13481	T13482	nsubj	results,suggest
R3756	T13483	T13484	det	the,defects
R3757	T13484	T13487	nsubjpass	defects,caused
R3758	T13485	T13486	compound	germ,cell
R3759	T13486	T13484	compound	cell,defects
R3760	T13487	T13482	advcl	caused,suggest
R3761	T13488	T13484	prep	of,defects
R3762	T13489	T13490	compound	Dmrt7,mutants
R3763	T13490	T13488	pobj	mutants,of
R3764	T13491	T13487	auxpass	are,caused
R3765	T13492	T13487	neg	not,caused
R3766	T13493	T13487	agent	by,caused
R3767	T13494	T13493	pobj	lack,by
R3768	T13495	T13494	prep	of,lack
R3769	T13496	T13495	pobj	Dmrt7,of
R3770	T13497	T13494	prep	in,lack
R3771	T13498	T13499	compound	Sertoli,cells
R3772	T13499	T13497	pobj	cells,in
R3773	T13500	T13482	punct	.,suggest
R3774	T13502	T13503	advmod	Rather,appears
R3775	T13504	T13503	punct	", ",appears
R3776	T13505	T13506	det	the,organization
R3777	T13506	T13503	nsubj	organization,appears
R3778	T13507	T13506	amod	abnormal,organization
R3779	T13508	T13506	prep	of,organization
R3780	T13509	T13510	compound	Sertoli,cells
R3781	T13510	T13508	pobj	cells,of
R3782	T13511	T13512	aux	to,result
R3783	T13512	T13503	xcomp	result,appears
R3784	T13513	T13512	prep	from,result
R3785	T13514	T13513	pobj	lack,from
R3786	T13515	T13514	prep	of,lack
R3787	T13516	T13515	pobj	Dmrt7,of
R3788	T13517	T13514	prep	in,lack
R3789	T13518	T13519	det	the,line
R3790	T13519	T13517	pobj	line,in
R3791	T13520	T13519	compound	germ,line
R3792	T13521	T13503	punct	.,appears
R3799	T14689	T14690	compound	XY,Bodies
R3800	T14690	T14691	nsubj	Bodies,Form
R3801	T14692	T14691	advmod	Normally,Form
R3802	T14693	T14691	prep	in,Form
R3803	T14694	T14695	compound	Dmrt7,Mutant
R3804	T14695	T14696	compound	Mutant,Cells
R3805	T14696	T14693	pobj	Cells,in
R3806	T14698	T14699	det	The,data
R3807	T14699	T14700	nsubj	data,indicate
R3808	T14701	T14699	acl	presented,data
R3809	T14702	T14703	advmod	so,far
R3810	T14703	T14701	advmod	far,presented
R3811	T14704	T14705	mark	that,undergo
R3812	T14705	T14700	ccomp	undergo,indicate
R3813	T14706	T14707	compound	Dmrt7,cells
R3814	T14707	T14705	nsubj	cells,undergo
R3815	T14708	T14707	compound	mutant,cells
R3816	T14709	T14707	compound	germ,cells
R3817	T14710	T14711	advmod	apparently,normal
R3818	T14711	T14712	amod	normal,meiosis
R3819	T14712	T14705	dobj	meiosis,undergo
R3820	T14713	T14712	amod	early,meiosis
R3821	T14714	T14705	cc	and,undergo
R3822	T14715	T14716	advmod	then,arrest
R3823	T14716	T14705	conj	arrest,undergo
R3824	T14717	T14716	prep	during,arrest
R3825	T14718	T14717	pobj	pachynema,during
R3826	T14719	T14716	prep	due,arrest
R3827	T14720	T14719	pcomp	to,due
R3828	T14721	T14722	det	a,requirement
R3829	T14722	T14719	pobj	requirement,due
R3830	T14723	T14722	amod	strict,requirement
R3831	T14724	T14722	prep	for,requirement
R3832	T14725	T14724	pobj	Dmrt7,for
R3833	T14726	T14722	prep	in,requirement
R3834	T14727	T14728	det	the,line
R3835	T14728	T14726	pobj	line,in
R3836	T14729	T14728	compound	germ,line
R3837	T14730	T14700	punct	.,indicate
R3838	T14732	T14733	aux	To,understand
R3839	T14733	T14735	advcl	understand,examined
R3840	T14734	T14733	advmod	better,understand
R3841	T14736	T14737	det	the,basis
R3842	T14737	T14733	dobj	basis,understand
R3843	T14738	T14737	prep	of,basis
R3844	T14739	T14740	det	the,arrest
R3845	T14740	T14738	pobj	arrest,of
R3846	T14741	T14740	amod	meiotic,arrest
R3847	T14742	T14735	punct	", ",examined
R3848	T14743	T14735	nsubj	we,examined
R3849	T14744	T14745	advmod	more,closely
R3850	T14745	T14735	advmod	closely,examined
R3851	T14746	T14747	amod	meiotic,cells
R3852	T14747	T14735	dobj	cells,examined
R3853	T14748	T14747	compound	germ,cells
R3854	T14749	T14735	prep	in,examined
R3855	T14750	T14751	det	the,mutant
R3856	T14751	T14749	pobj	mutant,in
R3857	T14752	T14735	punct	.,examined
R3858	T14754	T14755	nsubj	We,focused
R3859	T14756	T14755	prep	on,focused
R3860	T14757	T14758	det	the,body
R3861	T14758	T14756	pobj	body,on
R3862	T14759	T14758	compound	XY,body
R3863	T14760	T14758	punct	", ",body
R3864	T14761	T14762	dep	which,thought
R3865	T14762	T14758	relcl	thought,body
R3866	T14763	T14762	auxpass	is,thought
R3867	T14764	T14765	aux	to,be
R3868	T14765	T14762	xcomp	be,thought
R3869	T14766	T14765	acomp	essential,be
R3870	T14767	T14766	prep	for,essential
R3871	T14768	T14769	amod	meiotic,progression
R3872	T14769	T14767	pobj	progression,for
R3873	T14770	T14762	cc	and,thought
R3874	T14771	T14762	conj	is,thought
R3875	T14772	T14773	det	the,site
R3876	T14773	T14771	attr	site,is
R3877	T14774	T14773	prep	of,site
R3878	T14775	T14776	amod	preferential,localization
R3879	T14776	T14774	pobj	localization,of
R3880	T14777	T14776	compound	DMRT7,localization
R3881	T14778	T14755	punct	.,focused
R3882	T14780	T14781	nsubj	Condensation,begins
R3883	T14782	T14780	prep	of,Condensation
R3884	T14783	T14784	det	the,chromosomes
R3885	T14784	T14782	pobj	chromosomes,of
R3886	T14785	T14784	nmod	X,chromosomes
R3887	T14786	T14785	cc	and,X
R3888	T14787	T14785	conj	Y,X
R3889	T14788	T14781	prep	in,begins
R3890	T14789	T14790	amod	late,zygotene
R3891	T14790	T14792	compound	zygotene,cells
R3892	T14791	T14790	punct	-,zygotene
R3893	T14792	T14788	pobj	cells,in
R3894	T14793	T14781	punct	", ",begins
R3895	T14794	T14781	cc	and,begins
R3896	T14795	T14781	punct	", ",begins
R3897	T14796	T14797	prep	by,forms
R3898	T14797	T14781	conj	forms,begins
R3899	T14798	T14796	pobj	mid-pachynema,by
R3900	T14799	T14800	punct	(,aligned
R3901	T14800	T14798	parataxis	aligned,mid-pachynema
R3902	T14801	T14800	advmod	when,aligned
R3903	T14802	T14803	amod	homologous,pairs
R3904	T14803	T14800	nsubjpass	pairs,aligned
R3905	T14804	T14803	compound	chromosome,pairs
R3906	T14805	T14800	auxpass	are,aligned
R3907	T14806	T14800	advmod	fully,aligned
R3908	T14807	T14800	punct	),aligned
R3909	T14808	T14809	det	the,chromatin
R3910	T14809	T14797	nsubj	chromatin,forms
R3911	T14810	T14809	compound	sex,chromatin
R3912	T14811	T14812	det	a,structure
R3913	T14812	T14797	dobj	structure,forms
R3914	T14813	T14814	advmod	microscopically,visible
R3915	T14814	T14812	amod	visible,structure
R3916	T14815	T14812	amod	spherical,structure
R3917	T14816	T14797	prep	near,forms
R3918	T14817	T14818	det	the,periphery
R3919	T14818	T14816	pobj	periphery,near
R3920	T14819	T14818	amod	nuclear,periphery
R3921	T14820	T14821	punct	[,53
R3922	T14821	T14797	parataxis	53,forms
R3923	T14822	T14821	punct	],53
R3924	T14823	T14797	punct	.,forms
R3925	T14825	T14826	nsubj	We,asked
R3926	T14827	T14826	advmod	first,asked
R3927	T14828	T14829	mark	whether,required
R3928	T14829	T14826	ccomp	required,asked
R3929	T14830	T14829	nsubjpass	DMRT7,required
R3930	T14831	T14829	auxpass	is,required
R3931	T14832	T14829	prep	for,required
R3932	T14833	T14834	compound	XY,body
R3933	T14834	T14835	compound	body,formation
R3934	T14835	T14832	pobj	formation,for
R3935	T14836	T14826	prep	by,asked
R3936	T14837	T14836	pcomp	evaluating,by
R3937	T14838	T14839	amod	several,features
R3938	T14839	T14837	dobj	features,evaluating
R3939	T14840	T14839	amod	characteristic,features
R3940	T14841	T14842	compound	XY,body
R3941	T14842	T14839	compound	body,features
R3942	T14843	T14839	compound	chromatin,features
R3943	T14844	T14826	punct	.,asked
R3944	T14846	T14847	advmod	First,tested
R3945	T14848	T14847	punct	", ",tested
R3946	T14849	T14847	nsubj	we,tested
R3947	T14850	T14851	compound	γH2AX,expression
R3948	T14851	T14847	dobj	expression,tested
R3949	T14852	T14847	prep	by,tested
R3950	T14853	T14854	amod	immunofluorescent,staining
R3951	T14854	T14852	pobj	staining,by
R3952	T14855	T14847	punct	.,tested
R3953	T14857	T14858	nsubj	H2AX,is
R3954	T14859	T14860	det	a,variant
R3955	T14860	T14858	attr	variant,is
R3956	T14861	T14860	prep	of,variant
R3957	T14862	T14861	pobj	H2A,of
R3958	T14863	T14864	dep	that,is
R3959	T14864	T14860	relcl	is,variant
R3960	T14865	T14864	acomp	crucial,is
R3961	T14866	T14865	prep	for,crucial
R3962	T14867	T14868	compound	XY,body
R3963	T14868	T14869	compound	body,formation
R3964	T14869	T14866	pobj	formation,for
R3965	T14870	T14869	cc	and,formation
R3966	T14871	T14869	conj	MSCI,formation
R3967	T14872	T14873	punct	[,12
R3968	T14873	T14858	parataxis	12,is
R3969	T14874	T14873	punct	],12
R3970	T14875	T14858	punct	.,is
R3971	T14877	T14878	nsubj	γH2AX,localized
R3972	T14879	T14878	advmod	normally,localized
R3973	T14880	T14878	prep	to,localized
R3974	T14881	T14882	det	the,body
R3975	T14882	T14880	pobj	body,to
R3976	T14883	T14882	compound	XY,body
R3977	T14884	T14882	prep	of,body
R3978	T14885	T14886	compound	DMRT7,cells
R3979	T14886	T14884	pobj	cells,of
R3980	T14887	T14886	compound	mutant,cells
R3981	T14888	T14878	prep	in,localized
R3982	T14889	T14890	amod	meiotic,spreads
R3983	T14890	T14888	pobj	spreads,in
R3984	T14891	T14892	punct	(,7A
R3985	T14892	T14878	parataxis	7A,localized
R3986	T14893	T14892	compound	Figure,7A
R3987	T14894	T14892	punct	),7A
R3988	T14895	T14878	punct	", ",localized
R3989	T14896	T14878	cc	and,localized
R3990	T14897	T14898	amod	many,puncta
R3991	T14898	T14902	nsubj	puncta,were
R3992	T14899	T14900	npadvmod	γH2AX,positive
R3993	T14900	T14898	amod	positive,puncta
R3994	T14901	T14900	punct	-,positive
R3995	T14902	T14878	conj	were,localized
R3996	T14903	T14902	acomp	present,were
R3997	T14904	T14902	prep	in,were
R3998	T14905	T14906	compound	germ,cells
R3999	T14906	T14904	pobj	cells,in
R4000	T14907	T14906	prep	of,cells
R4001	T14908	T14909	compound	Dmrt7,mutant
R4002	T14909	T14910	compound	mutant,testes
R4003	T14910	T14907	pobj	testes,of
R4004	T14911	T14912	punct	(,7B
R4005	T14912	T14902	parataxis	7B,were
R4006	T14913	T14912	compound	Figure,7B
R4007	T14914	T14912	punct	),7B
R4008	T14915	T14902	punct	.,were
R4009	T14917	T14918	advmod	Next,examined
R4010	T14919	T14918	punct	", ",examined
R4011	T14920	T14918	nsubj	we,examined
R4012	T14921	T14922	nmod	SUMO,localization
R4013	T14922	T14918	dobj	localization,examined
R4014	T14923	T14921	punct	-,SUMO
R4015	T14924	T14921	nummod	1,SUMO
R4016	T14925	T14918	prep	in,examined
R4017	T14926	T14927	det	the,testis
R4018	T14927	T14925	pobj	testis,in
R4019	T14928	T14927	compound	mutant,testis
R4020	T14929	T14918	punct	.,examined
R4021	T14931	T14932	nmod	SUMO,expression
R4022	T14932	T14935	nsubj	expression,increases
R4023	T14933	T14931	punct	-,SUMO
R4024	T14934	T14931	nummod	1,SUMO
R4025	T14936	T14935	advmod	normally,increases
R4026	T14937	T14935	prep	in,increases
R4027	T14938	T14939	det	the,body
R4028	T14939	T14937	pobj	body,in
R4029	T14940	T14939	compound	XY,body
R4030	T14941	T14939	prep	of,body
R4031	T14942	T14943	amod	early,spermatocytes
R4032	T14943	T14941	pobj	spermatocytes,of
R4033	T14944	T14942	punct	-,early
R4034	T14945	T14942	prep	to,early
R4035	T14946	T14945	pobj	mid-pachytene,to
R4036	T14947	T14935	prep	at,increases
R4037	T14948	T14949	det	the,time
R4038	T14949	T14947	pobj	time,at
R4039	T14950	T14949	prep	of,time
R4040	T14951	T14952	compound	sex,chromosome
R4041	T14952	T14953	compound	chromosome,condensation
R4042	T14953	T14950	pobj	condensation,of
R4043	T14954	T14935	punct	.,increases
R4044	T14956	T14957	prep	Prior,disappears
R4045	T14958	T14956	prep	to,Prior
R4046	T14959	T14960	det	the,completion
R4047	T14960	T14958	pobj	completion,to
R4048	T14961	T14960	prep	of,completion
R4049	T14962	T14963	det	the,division
R4050	T14963	T14961	pobj	division,of
R4051	T14964	T14963	amod	first,division
R4052	T14965	T14963	amod	meiotic,division
R4053	T14966	T14957	punct	", ",disappears
R4054	T14967	T14957	nsubj	SUMO,disappears
R4055	T14968	T14967	punct	-,SUMO
R4056	T14969	T14967	nummod	1,SUMO
R4057	T14970	T14957	prep	from,disappears
R4058	T14971	T14972	det	the,body
R4059	T14972	T14970	pobj	body,from
R4060	T14973	T14972	compound	XY,body
R4061	T14974	T14975	mark	as,desynapse
R4062	T14975	T14957	advcl	desynapse,disappears
R4063	T14976	T14977	det	the,chromosomes
R4064	T14977	T14975	nsubj	chromosomes,desynapse
R4065	T14978	T14977	nmod	X,chromosomes
R4066	T14979	T14978	cc	and,X
R4067	T14980	T14978	conj	Y,X
R4068	T14981	T14982	punct	[,40
R4069	T14982	T14957	parataxis	40,disappears
R4070	T14983	T14982	punct	],40
R4071	T14984	T14957	punct	.,disappears
R4072	T14986	T14987	amod	Punctate,localization
R4073	T14987	T14991	nsubj	localization,was
R4074	T14988	T14987	nmod	SUMO,localization
R4075	T14989	T14988	punct	-,SUMO
R4076	T14990	T14988	nummod	1,SUMO
R4077	T14992	T14991	acomp	present,was
R4078	T14993	T14991	prep	in,was
R4079	T14994	T14995	compound	Dmrt7,cells
R4080	T14995	T14993	pobj	cells,in
R4081	T14996	T14995	compound	mutant,cells
R4082	T14997	T14995	compound	germ,cells
R4083	T14998	T14991	punct	", ",was
R4084	T14999	T15000	advmod	again,consistent
R4085	T15000	T14991	advcl	consistent,was
R4086	T15001	T15000	prep	with,consistent
R4087	T15002	T15001	pobj	formation,with
R4088	T15003	T15002	prep	of,formation
R4089	T15004	T15005	det	a,body
R4090	T15005	T15003	pobj	body,of
R4091	T15006	T15007	advmod	correctly,marked
R4092	T15007	T15005	amod	marked,body
R4093	T15008	T15005	compound	XY,body
R4094	T15009	T15010	punct	(,7C
R4095	T15010	T14991	parataxis	7C,was
R4096	T15011	T15010	compound	Figure,7C
R4097	T15012	T15010	punct	),7C
R4098	T15013	T14991	punct	.,was
R4099	T15015	T15016	advmod	However,had
R4100	T15017	T15016	punct	", ",had
R4101	T15018	T15019	det	some,tubules
R4102	T15019	T15016	nsubj	tubules,had
R4103	T15020	T15019	prep	in,tubules
R4104	T15021	T15020	pobj	mutants,in
R4105	T15022	T15023	amod	multiple,layers
R4106	T15023	T15016	dobj	layers,had
R4107	T15024	T15023	prep	of,layers
R4108	T15025	T15024	pobj	cells,of
R4109	T15026	T15023	prep	with,layers
R4110	T15027	T15028	npadvmod	SUMO,condensed
R4111	T15028	T15032	amod	condensed,spots
R4112	T15029	T15027	punct	-,SUMO
R4113	T15030	T15027	nummod	1,SUMO
R4114	T15031	T15028	punct	-,condensed
R4115	T15032	T15026	pobj	spots,with
R4116	T15033	T15034	punct	(,7C
R4117	T15034	T15032	parataxis	7C,spots
R4118	T15035	T15034	compound	Figure,7C
R4119	T15036	T15034	punct	),7C
R4120	T15037	T15032	punct	", ",spots
R4121	T15038	T15039	advmod	rather,than
R4122	T15039	T15032	cc	than,spots
R4123	T15040	T15041	det	the,layer
R4124	T15041	T15032	conj	layer,spots
R4125	T15042	T15041	amod	normal,layer
R4126	T15043	T15041	amod	single,layer
R4127	T15044	T15041	prep	of,layer
R4128	T15045	T15044	pobj	cells,of
R4129	T15046	T15016	punct	.,had
R4130	T15048	T15049	det	This,accumulation
R4131	T15049	T15050	nsubj	accumulation,was
R4132	T15051	T15049	prep	of,accumulation
R4133	T15052	T15053	compound	XY,body
R4134	T15053	T15054	npadvmod	body,containing
R4135	T15054	T15056	amod	containing,cells
R4136	T15055	T15054	punct	–,containing
R4137	T15056	T15051	pobj	cells,of
R4138	T15057	T15050	advmod	also,was
R4139	T15058	T15050	acomp	apparent,was
R4140	T15059	T15050	prep	with,was
R4141	T15060	T15061	compound	γH2AX,staining
R4142	T15061	T15059	pobj	staining,with
R4143	T15062	T15050	cc	and,was
R4144	T15063	T15050	conj	is,was
R4145	T15064	T15063	acomp	consistent,is
R4146	T15065	T15064	prep	with,consistent
R4147	T15066	T15067	det	a,arrest
R4148	T15067	T15065	pobj	arrest,with
R4149	T15068	T15067	amod	developmental,arrest
R4150	T15069	T15067	prep	of,arrest
R4151	T15070	T15071	compound	mutant,cells
R4152	T15071	T15069	pobj	cells,of
R4153	T15072	T15067	prep	in,arrest
R4154	T15073	T15074	amod	mid,pachytene
R4155	T15074	T15072	pobj	pachytene,in
R4156	T15075	T15073	punct	-,mid
R4157	T15076	T15073	prep	to,mid
R4158	T15077	T15076	amod	late,to
R4159	T15078	T15074	punct	-,pachytene
R4160	T15079	T15050	punct	.,was
R4161	T15081	T15082	nsubj	We,examined
R4162	T15083	T15082	advmod	also,examined
R4163	T15084	T15085	compound	Ub,H2A
R4164	T15085	T15087	compound	H2A,localization
R4165	T15086	T15085	punct	-,H2A
R4166	T15087	T15082	dobj	localization,examined
R4167	T15088	T15087	prep	in,localization
R4168	T15089	T15090	compound	Dmrt7,mutant
R4169	T15090	T15091	compound	mutant,testes
R4170	T15091	T15088	pobj	testes,in
R4171	T15092	T15082	punct	.,examined
R4172	T15094	T15095	prep	In,concentrated
R4173	T15095	T15104	ccomp	concentrated,observed
R4174	T15096	T15097	amod	early,pachytene
R4175	T15097	T15094	pobj	pachytene,In
R4176	T15098	T15097	punct	-,pachytene
R4177	T15099	T15095	punct	", ",concentrated
R4178	T15100	T15101	compound	Ub,H2A
R4179	T15101	T15095	nsubjpass	H2A,concentrated
R4180	T15102	T15101	punct	-,H2A
R4181	T15103	T15095	auxpass	is,concentrated
R4182	T15105	T15095	prep	in,concentrated
R4183	T15106	T15107	det	the,body
R4184	T15107	T15105	pobj	body,in
R4185	T15108	T15107	compound	XY,body
R4186	T15109	T15104	punct	;,observed
R4187	T15110	T15104	prep	by,observed
R4188	T15111	T15110	pobj	mid-pachytene,by
R4189	T15112	T15113	compound	Ub,H2A
R4190	T15113	T15104	nsubjpass	H2A,observed
R4191	T15114	T15113	punct	-,H2A
R4192	T15115	T15104	auxpass	is,observed
R4193	T15116	T15104	prep	throughout,observed
R4194	T15117	T15118	det	the,nucleus
R4195	T15118	T15116	pobj	nucleus,throughout
R4196	T15119	T15118	amod	entire,nucleus
R4197	T15120	T15104	punct	", ",observed
R4198	T15121	T15104	cc	but,observed
R4199	T15122	T15123	nsubj	it,becomes
R4200	T15123	T15104	conj	becomes,observed
R4201	T15124	T15123	advmod	again,becomes
R4202	T15125	T15123	acomp	limited,becomes
R4203	T15126	T15125	prep	to,limited
R4204	T15127	T15128	det	the,body
R4205	T15128	T15126	pobj	body,to
R4206	T15129	T15128	compound	XY,body
R4207	T15130	T15123	prep	in,becomes
R4208	T15131	T15132	amod	late,pachytene
R4209	T15132	T15134	compound	pachytene,spermatocytes
R4210	T15133	T15132	punct	-,pachytene
R4211	T15134	T15130	pobj	spermatocytes,in
R4212	T15135	T15136	punct	[,13
R4213	T15136	T15123	parataxis	13,becomes
R4214	T15137	T15136	punct	],13
R4215	T15138	T15104	punct	.,observed
R4216	T15140	T15141	nsubj	Analysis,revealed
R4217	T15142	T15140	prep	of,Analysis
R4218	T15143	T15144	amod	nuclear,spreads
R4219	T15144	T15142	pobj	spreads,of
R4220	T15145	T15146	mark	that,localizes
R4221	T15146	T15141	ccomp	localizes,revealed
R4222	T15147	T15148	compound	Ub,H2A
R4223	T15148	T15146	nsubj	H2A,localizes
R4224	T15149	T15148	punct	-,H2A
R4225	T15150	T15146	advmod	normally,localizes
R4226	T15151	T15146	prep	to,localizes
R4227	T15152	T15153	det	the,body
R4228	T15153	T15151	pobj	body,to
R4229	T15154	T15153	compound	XY,body
R4230	T15155	T15146	prep	in,localizes
R4231	T15156	T15157	compound	Dmrt7,mutants
R4232	T15157	T15155	pobj	mutants,in
R4233	T15158	T15159	punct	(,S4
R4234	T15159	T15141	parataxis	S4,revealed
R4235	T15160	T15159	compound	Figure,S4
R4236	T15161	T15159	punct	),S4
R4237	T15162	T15141	punct	.,revealed
R4238	T15164	T15165	advmod	Collectively,indicate
R4239	T15166	T15165	punct	", ",indicate
R4240	T15167	T15168	det	these,results
R4241	T15168	T15165	nsubj	results,indicate
R4242	T15169	T15170	mark	that,establish
R4243	T15170	T15165	ccomp	establish,indicate
R4244	T15171	T15172	compound	Dmrt7,cells
R4245	T15172	T15170	nsubj	cells,establish
R4246	T15173	T15172	compound	mutant,cells
R4247	T15174	T15172	compound	germ,cells
R4248	T15175	T15170	aux	can,establish
R4249	T15176	T15177	det	an,body
R4250	T15177	T15170	dobj	body,establish
R4251	T15178	T15177	compound	XY,body
R4252	T15179	T15170	prep	with,establish
R4253	T15180	T15181	advmod	at,least
R4254	T15181	T15182	advmod	least,some
R4255	T15182	T15179	pobj	some,with
R4256	T15183	T15182	prep	of,some
R4257	T15184	T15185	det	the,marks
R4258	T15185	T15183	pobj	marks,of
R4259	T15186	T15185	amod	normal,marks
R4260	T15187	T15185	compound	chromatin,marks
R4261	T15188	T15165	punct	.,indicate
R4262	T17284	T17285	amod	Abnormal,Chromatin
R4263	T17286	T17285	compound	Sex,Chromatin
R4264	T17287	T17285	prep	in,Chromatin
R4265	T17288	T17289	compound	Dmrt7,Mutant
R4266	T17289	T17290	compound	Mutant,Cells
R4267	T17290	T17287	pobj	Cells,in
R4268	T17291	T17290	compound	Germ,Cells
R4269	T17293	T17294	mark	Although,form
R4270	T17294	T17299	advcl	form,considered
R4271	T17295	T17296	det	the,body
R4272	T17296	T17294	nsubj	body,form
R4273	T17297	T17296	compound	XY,body
R4274	T17298	T17294	aux	can,form
R4275	T17300	T17294	prep	during,form
R4276	T17301	T17300	pobj	pachynema,during
R4277	T17302	T17294	prep	in,form
R4278	T17303	T17304	compound	Dmrt7,mutants
R4279	T17304	T17302	pobj	mutants,in
R4280	T17305	T17299	punct	", ",considered
R4281	T17306	T17299	nsubj	we,considered
R4282	T17307	T17308	det	the,possibility
R4283	T17308	T17299	dobj	possibility,considered
R4284	T17309	T17310	mark	that,established
R4285	T17310	T17308	acl	established,possibility
R4286	T17311	T17312	amod	transcriptional,silencing
R4287	T17312	T17310	nsubjpass	silencing,established
R4288	T17313	T17310	aux	might,established
R4289	T17314	T17310	neg	not,established
R4290	T17315	T17310	auxpass	be,established
R4291	T17316	T17310	advmod	properly,established
R4292	T17317	T17299	punct	.,considered
R4293	T17319	T17320	nsubj	This,be
R4294	T17320	T17322	ccomp	be,eliminated
R4295	T17321	T17320	aux	would,be
R4296	T17323	T17320	acomp	consistent,be
R4297	T17324	T17323	prep	with,consistent
R4298	T17325	T17326	det	the,phenotype
R4299	T17326	T17324	pobj	phenotype,with
R4300	T17327	T17326	compound	Dmrt7,phenotype
R4301	T17328	T17322	punct	: ,eliminated
R4302	T17329	T17330	compound	pachytene,cells
R4303	T17330	T17322	nsubjpass	cells,eliminated
R4304	T17331	T17332	dep	that,escape
R4305	T17332	T17330	relcl	escape,cells
R4306	T17333	T17332	prep	from,escape
R4307	T17334	T17333	pobj	MSCI,from
R4308	T17335	T17322	advmod	normally,eliminated
R4309	T17336	T17322	auxpass	are,eliminated
R4310	T17337	T17322	prep	prior,eliminated
R4311	T17338	T17337	prep	to,prior
R4312	T17339	T17340	amod	late,pachytene
R4313	T17340	T17338	pobj	pachytene,to
R4314	T17341	T17340	punct	-,pachytene
R4315	T17342	T17343	punct	[,17
R4316	T17343	T17322	parataxis	17,eliminated
R4317	T17344	T17343	punct	],17
R4318	T17345	T17322	punct	.,eliminated
R4319	T17347	T17348	advmod	Recently,shown
R4320	T17349	T17348	punct	", ",shown
R4321	T17350	T17348	nsubjpass	MSCI,shown
R4322	T17351	T17348	aux	has,shown
R4323	T17352	T17348	auxpass	been,shown
R4324	T17353	T17354	aux	to,continue
R4325	T17354	T17348	xcomp	continue,shown
R4326	T17355	T17354	prep	into,continue
R4327	T17356	T17355	pobj	meiosis,into
R4328	T17357	T17356	nummod	II,meiosis
R4329	T17358	T17356	cc	and,meiosis
R4330	T17359	T17356	conj	spermiogenesis,meiosis
R4331	T17360	T17354	punct	", ",continue
R4332	T17361	T17362	advmod	apparently,mediated
R4333	T17362	T17354	advcl	mediated,continue
R4334	T17363	T17362	prep	by,mediated
R4335	T17364	T17365	det	a,compartment
R4336	T17365	T17363	pobj	compartment,by
R4337	T17366	T17365	amod	distinct,compartment
R4338	T17367	T17365	compound	chromatin,compartment
R4339	T17368	T17365	acl	termed,compartment
R4340	T17369	T17370	amod	postmeiotic,chromatin
R4341	T17370	T17368	oprd	chromatin,termed
R4342	T17371	T17370	compound	sex,chromatin
R4343	T17372	T17370	punct	(,chromatin
R4344	T17373	T17370	appos	PMSC,chromatin
R4345	T17374	T17365	punct	),compartment
R4346	T17375	T17376	dep	that,established
R4347	T17376	T17365	relcl	established,compartment
R4348	T17377	T17376	auxpass	is,established
R4349	T17378	T17376	advcl	starting,established
R4350	T17379	T17378	prep	in,starting
R4351	T17380	T17379	pobj	diplonema,in
R4352	T17381	T17382	punct	[,16
R4353	T17382	T17348	parataxis	16,shown
R4354	T17383	T17382	punct	],16
R4355	T17384	T17348	punct	.,shown
R4356	T17386	T17387	nsubj	We,asked
R4357	T17388	T17387	advmod	therefore,asked
R4358	T17389	T17390	mark	whether,associated
R4359	T17390	T17387	ccomp	associated,asked
R4360	T17391	T17392	det	the,death
R4361	T17392	T17390	nsubjpass	death,associated
R4362	T17393	T17392	compound	pachytene,death
R4363	T17394	T17395	compound	germ,cell
R4364	T17395	T17392	compound	cell,death
R4365	T17396	T17392	prep	in,death
R4366	T17397	T17398	compound	Dmrt7,mutants
R4367	T17398	T17396	pobj	mutants,in
R4368	T17399	T17390	auxpass	is,associated
R4369	T17400	T17390	prep	with,associated
R4370	T17401	T17402	det	a,failure
R4371	T17402	T17400	pobj	failure,with
R4372	T17403	T17404	preconj	either,initiate
R4373	T17404	T17402	acl	initiate,failure
R4374	T17405	T17404	aux	to,initiate
R4375	T17406	T17404	cc	or,initiate
R4376	T17407	T17408	aux	to,maintain
R4377	T17408	T17404	conj	maintain,initiate
R4378	T17409	T17410	compound	sex,chromosome
R4379	T17410	T17411	compound	chromosome,inactivation
R4380	T17411	T17408	dobj	inactivation,maintain
R4381	T17412	T17387	punct	.,asked
R4382	T17414	T17415	advmod	First,examined
R4383	T17416	T17415	punct	", ",examined
R4384	T17417	T17415	nsubj	we,examined
R4385	T17418	T17419	det	the,body
R4386	T17419	T17415	dobj	body,examined
R4387	T17420	T17419	amod	mid-pachytene,body
R4388	T17421	T17419	compound	XY,body
R4389	T17422	T17415	punct	.,examined
R4390	T17424	T17425	aux	To,examine
R4391	T17425	T17426	advcl	examine,carried
R4392	T17427	T17428	nmod	XY,status
R4393	T17428	T17425	dobj	status,examine
R4394	T17429	T17428	amod	transcriptional,status
R4395	T17430	T17426	punct	", ",carried
R4396	T17431	T17426	nsubj	we,carried
R4397	T17432	T17426	prt	out,carried
R4398	T17433	T17434	nmod	Cot,hybridization
R4399	T17434	T17426	dobj	hybridization,carried
R4400	T17435	T17433	punct	-,Cot
R4401	T17436	T17433	nummod	1,Cot
R4402	T17437	T17434	nmod	RNA,hybridization
R4403	T17438	T17434	nmod	fluorescence,hybridization
R4404	T17439	T17440	advmod	in,situ
R4405	T17440	T17434	amod	situ,hybridization
R4406	T17441	T17434	punct	(,hybridization
R4407	T17442	T17434	appos	FISH,hybridization
R4408	T17443	T17434	punct	),hybridization
R4409	T17444	T17445	aux	to,detect
R4410	T17445	T17426	advcl	detect,carried
R4411	T17446	T17447	amod	nascent,transcription
R4412	T17447	T17445	dobj	transcription,detect
R4413	T17448	T17449	nmod	RNA,polymerase
R4414	T17449	T17447	nmod	polymerase,transcription
R4415	T17450	T17449	nummod	II,polymerase
R4416	T17451	T17447	punct	", ",transcription
R4417	T17452	T17447	acl	combined,transcription
R4418	T17453	T17452	prep	with,combined
R4419	T17454	T17455	compound	DAPI,staining
R4420	T17455	T17453	pobj	staining,with
R4421	T17456	T17457	aux	to,locate
R4422	T17457	T17426	advcl	locate,carried
R4423	T17458	T17459	det	the,body
R4424	T17459	T17457	dobj	body,locate
R4425	T17460	T17459	compound	XY,body
R4426	T17461	T17457	prep	on,locate
R4427	T17462	T17461	pobj	spreads,on
R4428	T17463	T17462	prep	of,spreads
R4429	T17464	T17465	amod	seminiferous,tubules
R4430	T17465	T17463	pobj	tubules,of
R4431	T17466	T17467	punct	(,8A
R4432	T17467	T17426	parataxis	8A,carried
R4433	T17468	T17467	compound	Figure,8A
R4434	T17469	T17467	cc	and,8A
R4435	T17470	T17467	conj	8B,8A
R4436	T17471	T17467	punct	),8A
R4437	T17472	T17426	punct	.,carried
R4438	T17474	T17475	prep	In,formed
R4439	T17476	T17477	compound	Dmrt7,mutants
R4440	T17477	T17474	pobj	mutants,In
R4441	T17478	T17475	punct	", ",formed
R4442	T17479	T17480	det	the,body
R4443	T17480	T17475	nsubjpass	body,formed
R4444	T17481	T17480	compound	XY,body
R4445	T17482	T17475	auxpass	was,formed
R4446	T17483	T17475	cc	and,formed
R4447	T17484	T17475	conj	excluded,formed
R4448	T17485	T17486	nmod	Cot,hybridization
R4449	T17486	T17484	dobj	hybridization,excluded
R4450	T17487	T17485	punct	-,Cot
R4451	T17488	T17485	nummod	1,Cot
R4452	T17489	T17490	punct	(,8B
R4453	T17490	T17475	parataxis	8B,formed
R4454	T17491	T17490	compound	Figure,8B
R4455	T17492	T17490	punct	),8B
R4456	T17493	T17475	punct	", ",formed
R4457	T17494	T17475	advcl	indicating,formed
R4458	T17495	T17496	mark	that,established
R4459	T17496	T17494	ccomp	established,indicating
R4460	T17497	T17498	amod	transcriptional,silencing
R4461	T17498	T17496	nsubjpass	silencing,established
R4462	T17499	T17496	auxpass	is,established
R4463	T17500	T17496	advmod	normally,established
R4464	T17501	T17496	prep	in,established
R4465	T17502	T17503	compound	mutant,cells
R4466	T17503	T17501	pobj	cells,in
R4467	T17504	T17503	compound	pachytene,cells
R4468	T17505	T17475	punct	.,formed
R4469	T17507	T17508	nsubj	We,examined
R4470	T17509	T17508	advmod	also,examined
R4471	T17510	T17508	dobj	expression,examined
R4472	T17511	T17510	prep	of,expression
R4473	T17512	T17513	det	the,gene
R4474	T17513	T17511	pobj	gene,of
R4475	T17514	T17515	npadvmod	Y,linked
R4476	T17515	T17513	amod	linked,gene
R4477	T17516	T17515	punct	-,linked
R4478	T17517	T17513	appos	Rbmy,gene
R4479	T17518	T17513	punct	", ",gene
R4480	T17519	T17520	dep	which,inactivated
R4481	T17520	T17513	relcl	inactivated,gene
R4482	T17521	T17520	advmod	normally,inactivated
R4483	T17522	T17520	auxpass	is,inactivated
R4484	T17523	T17520	prep	during,inactivated
R4485	T17524	T17523	pobj	pachytene,during
R4486	T17525	T17520	cc	and,inactivated
R4487	T17526	T17520	conj	reactivated,inactivated
R4488	T17527	T17528	mark	after,begins
R4489	T17528	T17526	advcl	begins,reactivated
R4490	T17529	T17530	amod	secondary,meiosis
R4491	T17530	T17528	nsubj	meiosis,begins
R4492	T17531	T17532	punct	[,55
R4493	T17532	T17508	parataxis	55,examined
R4494	T17533	T17532	nummod	54,55
R4495	T17534	T17532	punct	",",55
R4496	T17535	T17532	punct	],55
R4497	T17536	T17508	punct	.,examined
R4498	T17538	T17539	nsubjpass	Rbmy,inactivated
R4499	T17540	T17539	auxpass	was,inactivated
R4500	T17541	T17539	advmod	normally,inactivated
R4501	T17542	T17539	prep	in,inactivated
R4502	T17543	T17544	compound	pachytene,cells
R4503	T17544	T17542	pobj	cells,in
R4504	T17545	T17544	prep	of,cells
R4505	T17546	T17547	compound	Dmrt7,mutants
R4506	T17547	T17545	pobj	mutants,of
R4507	T17548	T17539	punct	", ",inactivated
R4508	T17549	T17539	prep	based,inactivated
R4509	T17550	T17549	prep	on,based
R4510	T17551	T17552	amod	immunofluorescent,staining
R4511	T17552	T17550	pobj	staining,on
R4512	T17553	T17552	prep	with,staining
R4513	T17554	T17555	det	an,antibody
R4514	T17555	T17553	pobj	antibody,with
R4515	T17556	T17555	amod	anti-RBMY,antibody
R4516	T17557	T17558	punct	(,S5
R4517	T17558	T17539	parataxis	S5,inactivated
R4518	T17559	T17558	compound	Figure,S5
R4519	T17560	T17558	punct	),S5
R4520	T17561	T17539	punct	.,inactivated
R4521	T17563	T17564	nsubj	We,examined
R4522	T17565	T17564	advmod	also,examined
R4523	T17566	T17567	nmod	heterochromatin,beta
R4524	T17567	T17564	dobj	beta,examined
R4525	T17568	T17567	nmod	protein,beta
R4526	T17569	T17567	nummod	1,beta
R4527	T17570	T17567	punct	(,beta
R4528	T17571	T17567	appos	HP1β,beta
R4529	T17572	T17567	punct	),beta
R4530	T17573	T17567	punct	", ",beta
R4531	T17574	T17575	dep	which,localizes
R4532	T17575	T17567	relcl	localizes,beta
R4533	T17576	T17575	advmod	normally,localizes
R4534	T17577	T17575	prep	to,localizes
R4535	T17578	T17579	det	the,centromere
R4536	T17579	T17577	pobj	centromere,to
R4537	T17580	T17579	compound	X,centromere
R4538	T17581	T17575	prep	at,localizes
R4539	T17582	T17581	pobj	mid-pachynema,at
R4540	T17583	T17575	cc	and,localizes
R4541	T17584	T17585	advmod	then,spreads
R4542	T17585	T17575	conj	spreads,localizes
R4543	T17586	T17585	prep	through,spreads
R4544	T17587	T17588	det	the,body
R4546	T17589	T17588	compound	XY,body
R4547	T17590	T17591	mark	as,internalizes
R4548	T17591	T17585	advcl	internalizes,spreads
R4549	T17592	T17591	nsubj	it,internalizes
R4550	T17593	T17591	prep	during,internalizes
R4551	T17594	T17593	pobj	diplonema,during
R4552	T17595	T17596	punct	[,56
R4553	T17596	T17567	parataxis	56,beta
R4554	T17597	T17596	punct	],56
R4555	T17598	T17564	punct	.,examined
R4556	T17600	T17601	nsubj	We,found
R4557	T17602	T17603	mark	that,is
R4558	T17603	T17601	ccomp	is,found
R4559	T17604	T17605	compound	HP1β,localization
R4560	T17605	T17603	nsubj	localization,is
R4561	T17606	T17603	acomp	normal,is
R4562	T17607	T17603	prep	in,is
R4563	T17608	T17609	compound	DMRT7,cells
R4564	T17609	T17607	pobj	cells,in
R4565	T17610	T17609	compound	mutant,cells
R4566	T17611	T17603	prep	in,is
R4567	T17612	T17611	pobj	mid-pachynema,in
R4568	T17613	T17614	punct	(,8C
R4569	T17614	T17601	parataxis	8C,found
R4570	T17615	T17614	compound	Figure,8C
R4571	T17616	T17614	cc	and,8C
R4572	T17617	T17614	conj	8D,8C
R4573	T17618	T17614	punct	),8C
R4574	T17619	T17601	punct	.,found
R4575	T17621	T17622	det	These,results
R4576	T17622	T17623	nsubj	results,suggest
R4577	T17624	T17625	mark	that,occur
R4578	T17625	T17623	ccomp	occur,suggest
R4579	T17626	T17627	compound	XY,formation
R4580	T17627	T17625	nsubj	formation,occur
R4581	T17628	T17627	compound	body,formation
R4582	T17629	T17627	cc	and,formation
R4583	T17630	T17627	conj	initiation,formation
R4584	T17631	T17627	prep	of,formation
R4585	T17632	T17631	pobj	MSCI,of
R4586	T17633	T17627	appos	both,formation
R4587	T17634	T17625	advmod	normally,occur
R4588	T17635	T17625	prep	in,occur
R4589	T17636	T17637	compound	Dmrt7,mutant
R4590	T17637	T17638	compound	mutant,cells
R4591	T17638	T17635	pobj	cells,in
R4592	T17639	T17638	compound	germ,cells
R4593	T17640	T17623	punct	.,suggest
R4594	T17643	T17644	nsubj	We,considered
R4595	T17645	T17644	advmod	next,considered
R4596	T17646	T17647	det	the,possibility
R4597	T17647	T17644	dobj	possibility,considered
R4598	T17648	T17649	mark	that,established
R4599	T17649	T17647	acl	established,possibility
R4600	T17650	T17651	compound	sex,chromatin
R4601	T17651	T17649	nsubjpass	chromatin,established
R4602	T17652	T17649	auxpass	is,established
R4603	T17653	T17649	advmod	normally,established
R4604	T17654	T17649	cc	but,established
R4605	T17655	T17656	auxpass	is,modified
R4606	T17656	T17649	conj	modified,established
R4607	T17657	T17656	neg	not,modified
R4608	T17658	T17656	advmod	properly,modified
R4609	T17659	T17660	mark	as,exit
R4610	T17660	T17656	advcl	exit,modified
R4611	T17661	T17660	nsubj	cells,exit
R4612	T17662	T17660	dobj	pachynema,exit
R4613	T17663	T17660	cc	and,exit
R4614	T17664	T17660	conj	begin,exit
R4615	T17665	T17666	aux	to,form
R4616	T17666	T17664	xcomp	form,begin
R4617	T17667	T17666	dobj	PMSC,form
R4618	T17668	T17644	punct	.,considered
R4619	T17670	T17671	mark	Although,eliminated
R4620	T17671	T17677	advcl	eliminated,were
R4621	T17672	T17673	amod	most,cells
R4622	T17673	T17671	nsubjpass	cells,eliminated
R4623	T17674	T17673	compound	Dmrt7,cells
R4624	T17675	T17673	compound	mutant,cells
R4625	T17676	T17671	auxpass	are,eliminated
R4626	T17678	T17671	prep	by,eliminated
R4627	T17679	T17678	pobj	apoptosis,by
R4628	T17680	T17671	prep	prior,eliminated
R4629	T17681	T17680	prep	to,prior
R4630	T17682	T17681	pobj	diplonema,to
R4631	T17683	T17677	punct	", ",were
R4632	T17684	T17677	nsubj	we,were
R4633	T17685	T17677	acomp	able,were
R4634	T17686	T17687	aux	to,examine
R4635	T17687	T17685	xcomp	examine,able
R4636	T17688	T17689	amod	epigenetic,markers
R4637	T17689	T17687	dobj	markers,examine
R4638	T17690	T17689	prep	of,markers
R4639	T17691	T17690	pobj	PMSC,of
R4640	T17692	T17689	prep	in,markers
R4641	T17693	T17694	amod	rare,spermatocytes
R4642	T17694	T17692	pobj	spermatocytes,in
R4643	T17695	T17696	compound	Dmrt7,mutant
R4644	T17696	T17694	compound	mutant,spermatocytes
R4645	T17697	T17698	dep	that,escaped
R4646	T17698	T17694	relcl	escaped,spermatocytes
R4647	T17699	T17700	compound	pachytene,arrest
R4648	T17700	T17698	dobj	arrest,escaped
R4649	T17701	T17698	cc	and,escaped
R4650	T17702	T17698	conj	progressed,escaped
R4651	T17703	T17702	prep	into,progressed
R4652	T17704	T17703	pobj	diplonema,into
R4653	T17705	T17677	punct	.,were
R4654	T17707	T17708	advmod	First,examined
R4655	T17709	T17708	punct	", ",examined
R4656	T17710	T17708	nsubj	we,examined
R4657	T17711	T17712	amod	nascent,transcription
R4658	T17712	T17708	dobj	transcription,examined
R4659	T17713	T17708	prep	by,examined
R4660	T17714	T17715	nmod	Cot,hybridization
R4661	T17715	T17713	pobj	hybridization,by
R4662	T17716	T17714	punct	-,Cot
R4663	T17717	T17714	nummod	1,Cot
R4664	T17718	T17708	punct	.,examined
R4665	T17720	T17721	mark	Although,showed
R4666	T17721	T17725	advcl	showed,appeared
R4667	T17722	T17723	amod	heterochromatic,regions
R4668	T17723	T17721	nsubj	regions,showed
R4669	T17724	T17721	advmod	generally,showed
R4670	T17726	T17727	amod	lower,signal
R4671	T17727	T17721	dobj	signal,showed
R4672	T17728	T17727	nmod	Cot,signal
R4673	T17729	T17728	punct	-,Cot
R4674	T17730	T17728	nummod	1,Cot
R4675	T17731	T17727	prep	than,signal
R4676	T17732	T17733	amod	euchromatic,regions
R4677	T17733	T17731	pobj	regions,than
R4678	T17734	T17735	punct	(,8E
R4679	T17735	T17721	parataxis	8E,showed
R4680	T17736	T17735	compound	Figure,8E
R4681	T17737	T17735	cc	and,8E
R4682	T17738	T17735	conj	8F,8E
R4683	T17739	T17735	punct	),8E
R4684	T17740	T17725	punct	", ",appeared
R4685	T17741	T17725	prep	in,appeared
R4686	T17742	T17743	det	some,cells
R4687	T17743	T17741	pobj	cells,in
R4688	T17744	T17743	compound	mutant,cells
R4689	T17745	T17746	det	the,chromatin
R4690	T17746	T17725	nsubj	chromatin,appeared
R4691	T17747	T17746	compound	sex,chromatin
R4692	T17748	T17749	aux	to,be
R4693	T17749	T17725	xcomp	be,appeared
R4694	T17750	T17751	advmod	incompletely,silenced
R4695	T17751	T17749	acomp	silenced,be
R4696	T17752	T17749	advcl	relative,be
R4697	T17753	T17752	prep	to,relative
R4698	T17754	T17755	amod	wild,type
R4699	T17755	T17753	pobj	type,to
R4700	T17756	T17755	punct	-,type
R4701	T17757	T17758	punct	(,8F
R4702	T17758	T17725	parataxis	8F,appeared
R4703	T17759	T17758	compound	Figure,8F
R4704	T17760	T17758	punct	),8F
R4705	T17761	T17725	punct	.,appeared
R4706	T17763	T17764	nsubj	We,examined
R4707	T17765	T17764	advmod	also,examined
R4708	T17766	T17767	nummod	three,signatures
R4709	T17767	T17764	dobj	signatures,examined
R4710	T17768	T17767	amod	epigenetic,signatures
R4711	T17769	T17767	prep	of,signatures
R4712	T17770	T17769	pobj	PMSC,of
R4713	T17771	T17767	punct	: ,signatures
R4714	T17772	T17773	compound	histone,H3
R4715	T17773	T17767	appos	H3,signatures
R4716	T17774	T17773	acl	dimethylated,H3
R4717	T17775	T17774	cc	or,dimethylated
R4718	T17776	T17774	conj	trimethylated,dimethylated
R4719	T17777	T17776	prep	at,trimethylated
R4720	T17778	T17777	pobj	lysine,at
R4721	T17779	T17778	punct	-,lysine
R4722	T17780	T17778	nummod	9,lysine
R4723	T17781	T17782	punct	(,2meK9
R4724	T17782	T17776	parataxis	2meK9,trimethylated
R4725	T17783	T17782	compound	H3,2meK9
R4726	T17784	T17782	punct	-,2meK9
R4727	T17785	T17782	punct	", ",2meK9
R4728	T17786	T17787	compound	H3,3meK9
R4729	T17787	T17782	appos	3meK9,2meK9
R4730	T17788	T17787	punct	-,3meK9
R4731	T17789	T17782	punct	),2meK9
R4732	T17790	T17773	cc	and,H3
R4733	T17791	T17773	conj	spreading,H3
R4734	T17792	T17791	prep	of,spreading
R4735	T17793	T17792	pobj	HP1β,of
R4736	T17794	T17791	prep	through,spreading
R4737	T17795	T17796	det	the,body
R4738	T17796	T17794	pobj	body,through
R4739	T17797	T17796	compound	XY,body
R4740	T17798	T17799	punct	[,58
R4741	T17799	T17764	parataxis	58,examined
R4742	T17800	T17799	nummod	16,58
R4743	T17801	T17799	punct	",",58
R4744	T17802	T17799	nummod	57,58
R4745	T17803	T17799	punct	",",58
R4746	T17804	T17799	punct	],58
R4747	T17805	T17806	punct	(,S.
R4748	T17806	T17764	meta	S.,examined
R4749	T17807	T17806	nmod	H.,S.
R4750	T17808	T17806	nmod	Namekawa,S.
R4751	T17809	T17806	punct	", ",S.
R4752	T17810	T17806	amod	unpublished,S.
R4753	T17811	T17806	nmod	data,S.
R4754	T17812	T17806	punct	),S.
R4755	T17813	T17764	punct	.,examined
R4756	T17815	T17816	nsubj	We,observed
R4757	T17817	T17816	dobj	defects,observed
R4758	T17818	T17817	prep	in,defects
R4759	T17819	T17820	compound	sex,chromatin
R4760	T17820	T17821	compound	chromatin,localization
R4761	T17821	T17818	pobj	localization,in
R4762	T17822	T17821	prep	of,localization
R4763	T17823	T17824	det	all,markers
R4764	T17824	T17822	pobj	markers,of
R4765	T17825	T17824	nummod	three,markers
R4766	T17826	T17824	prep	in,markers
R4767	T17827	T17828	compound	Dmrt7,diplotene
R4768	T17828	T17829	compound	diplotene,cells
R4769	T17829	T17826	pobj	cells,in
R4770	T17830	T17816	punct	.,observed
R4771	T17832	T17833	mark	Although,appeared
R4772	T17833	T17842	advcl	appeared,observed
R4773	T17834	T17835	compound	HP1β,localization
R4774	T17835	T17833	nsubj	localization,appeared
R4775	T17836	T17835	prep	to,localization
R4776	T17837	T17838	det	the,centromere
R4777	T17838	T17836	pobj	centromere,to
R4778	T17839	T17840	compound	X,chromosome
R4779	T17840	T17838	compound	chromosome,centromere
R4780	T17841	T17833	advmod	initially,appeared
R4781	T17843	T17833	oprd	normal,appeared
R4782	T17844	T17833	prep	at,appeared
R4783	T17845	T17844	pobj	mid-pachynema,at
R4784	T17846	T17842	punct	", ",observed
R4785	T17847	T17842	nsubj	we,observed
R4786	T17848	T17849	compound	Dmrt7,cells
R4787	T17849	T17842	dobj	cells,observed
R4788	T17850	T17849	compound	mutant,cells
R4789	T17851	T17849	compound	diplotene,cells
R4790	T17852	T17853	dep	that,failed
R4791	T17853	T17849	relcl	failed,cells
R4792	T17854	T17855	aux	to,show
R4793	T17855	T17853	xcomp	show,failed
R4794	T17856	T17855	dobj	spreading,show
R4795	T17857	T17856	prep	of,spreading
R4796	T17858	T17857	pobj	HP1β,of
R4797	T17859	T17856	prep	to,spreading
R4798	T17860	T17861	det	the,body
R4799	T17861	T17859	pobj	body,to
R4800	T17862	T17861	amod	entire,body
R4801	T17863	T17861	compound	XY,body
R4802	T17864	T17865	punct	(,8G
R4803	T17865	T17842	parataxis	8G,observed
R4804	T17866	T17865	compound	Figure,8G
R4805	T17867	T17865	cc	and,8G
R4806	T17868	T17865	conj	8H,8G
R4807	T17869	T17865	punct	),8G
R4808	T17870	T17842	punct	.,observed
R4809	T17872	T17873	advmod	Similarly,found
R4810	T17874	T17873	punct	", ",found
R4811	T17875	T17873	nsubj	we,found
R4812	T17876	T17877	compound	Dmrt7,cells
R4813	T17877	T17873	dobj	cells,found
R4814	T17878	T17877	compound	mutant,cells
R4815	T17879	T17877	compound	diplotene,cells
R4816	T17880	T17877	acl	lacking,cells
R4817	T17881	T17880	dobj	accumulation,lacking
R4818	T17882	T17881	prep	of,accumulation
R4819	T17883	T17884	nmod	H3,2meK9
R4820	T17884	T17886	nmod	2meK9,marks
R4821	T17885	T17884	punct	-,2meK9
R4822	T17886	T17882	pobj	marks,of
R4823	T17887	T17884	cc	and,2meK9
R4824	T17888	T17889	compound	H3,3meK9
R4825	T17889	T17884	conj	3meK9,2meK9
R4826	T17890	T17889	punct	-,3meK9
R4827	T17891	T17886	prep	onto,marks
R4828	T17892	T17893	det	the,chromatin
R4829	T17893	T17891	pobj	chromatin,onto
R4830	T17894	T17893	compound	sex,chromatin
R4831	T17895	T17896	punct	(,8I
R4832	T17896	T17873	parataxis	8I,found
R4833	T17897	T17896	compound	Figure,8I
R4834	T17898	T17899	punct	–,8L
R4835	T17899	T17896	prep	8L,8I
R4836	T17900	T17896	punct	),8I
R4837	T17901	T17873	punct	.,found
R4838	T17903	T17904	neg	Not,cells
R4839	T17904	T17909	nsubj	cells,showed
R4840	T17905	T17904	det	all,cells
R4841	T17906	T17907	compound	Dmrt7,mutant
R4842	T17907	T17904	compound	mutant,cells
R4843	T17908	T17904	compound	diplotene,cells
R4844	T17910	T17911	amod	abnormal,localization
R4845	T17911	T17909	dobj	localization,showed
R4846	T17912	T17911	prep	of,localization
R4847	T17913	T17912	pobj	HP1β,of
R4848	T17914	T17911	prep	to,localization
R4849	T17915	T17916	det	the,chromatin
R4850	T17916	T17914	pobj	chromatin,to
R4851	T17917	T17916	compound	sex,chromatin
R4852	T17918	T17919	punct	(,8M
R4853	T17919	T17909	parataxis	8M,showed
R4854	T17920	T17919	compound	Figure,8M
R4855	T17921	T17919	punct	),8M
R4856	T17922	T17909	punct	.,showed
R4857	T17924	T17925	prep	In,lacked
R4858	T17926	T17927	nummod	one,experiment
R4859	T17927	T17924	pobj	experiment,In
R4860	T17928	T17925	punct	", ",lacked
R4861	T17929	T17930	quantmod	11,27
R4862	T17930	T17932	nummod	27,cells
R4863	T17931	T17930	punct	/,27
R4864	T17932	T17925	nsubj	cells,lacked
R4865	T17933	T17932	compound	mutant,cells
R4866	T17934	T17932	prep	in,cells
R4867	T17935	T17934	pobj	diplonema,in
R4868	T17936	T17925	dobj	HP1β,lacked
R4869	T17937	T17925	prep	on,lacked
R4870	T17938	T17939	det	the,body
R4871	T17939	T17937	pobj	body,on
R4872	T17940	T17939	compound	XY,body
R4873	T17941	T17925	punct	", ",lacked
R4874	T17942	T17943	mark	as,compared
R4875	T17943	T17925	advcl	compared,lacked
R4876	T17944	T17943	prep	with,compared
R4877	T17945	T17946	quantmod	2,22
R4878	T17946	T17948	nummod	22,cells
R4879	T17947	T17946	punct	/,22
R4880	T17948	T17944	pobj	cells,with
R4881	T17949	T17950	amod	wild,type
R4882	T17950	T17948	compound	type,cells
R4883	T17951	T17950	punct	-,type
R4884	T17952	T17925	punct	.,lacked
R4885	T17954	T17955	nsubj	We,hypothesize
R4886	T17956	T17957	mark	that,be
R4887	T17957	T17955	ccomp	be,hypothesize
R4888	T17958	T17959	det	the,cells
R4889	T17959	T17957	nsubj	cells,be
R4890	T17960	T17959	compound	mutant,cells
R4891	T17961	T17959	prep	with,cells
R4892	T17962	T17963	amod	normal,HP1β
R4893	T17963	T17961	pobj	HP1β,with
R4894	T17964	T17957	aux	may,be
R4895	T17965	T17957	attr	those,be
R4896	T17966	T17967	dep	that,complete
R4897	T17967	T17965	relcl	complete,those
R4898	T17968	T17967	aux	can,complete
R4899	T17969	T17967	dobj	meiosis,complete
R4900	T17970	T17971	punct	(,4
R4901	T17971	T17955	parataxis	4,hypothesize
R4902	T17972	T17971	nmod	Figures,4
R4903	T17973	T17971	cc	and,4
R4904	T17974	T17971	conj	5,4
R4905	T17975	T17971	punct	),4
R4906	T17976	T17955	punct	.,hypothesize
R4907	T17978	T17979	nsubj	Some,had
R4908	T17980	T17978	prep	of,Some
R4909	T17981	T17982	det	the,cells
R4910	T17982	T17980	pobj	cells,of
R4911	T17983	T17982	compound	mutant,cells
R4912	T17984	T17982	compound	diplotene,cells
R4913	T17985	T17982	acl	showing,cells
R4914	T17986	T17987	amod	abnormal,chromatin
R4915	T17987	T17985	dobj	chromatin,showing
R4916	T17988	T17987	compound	sex,chromatin
R4917	T17989	T17979	advmod	also,had
R4918	T17990	T17991	amod	abnormal,staining
R4919	T17991	T17979	dobj	staining,had
R4920	T17992	T17991	amod	autosomal,staining
R4921	T17993	T17991	compound	γH2AX,staining
R4922	T17994	T17995	punct	(,8L
R4923	T17995	T17979	parataxis	8L,had
R4924	T17996	T17995	compound	Figure,8L
R4925	T17997	T17995	punct	),8L
R4926	T17998	T17979	punct	.,had
R4927	T18000	T18001	nsubj	γH2AX,localizes
R4928	T18002	T18001	prep	to,localizes
R4929	T18003	T18004	amod	double,strand
R4930	T18004	T18006	compound	strand,DNA
R4931	T18005	T18004	punct	-,strand
R4932	T18006	T18007	compound	DNA,breaks
R4933	T18007	T18002	pobj	breaks,to
R4934	T18008	T18001	punct	", ",localizes
R4935	T18009	T18010	mark	so,indicate
R4936	T18010	T18001	advcl	indicate,localizes
R4937	T18011	T18012	det	this,staining
R4938	T18012	T18010	nsubj	staining,indicate
R4939	T18013	T18010	aux	may,indicate
R4940	T18014	T18015	mark	that,approaching
R4941	T18015	T18010	ccomp	approaching,indicate
R4942	T18016	T18017	det	some,cells
R4943	T18017	T18015	nsubj	cells,approaching
R4944	T18018	T18017	compound	diplotene,cells
R4945	T18019	T18017	compound	mutant,cells
R4946	T18020	T18015	aux	are,approaching
R4947	T18021	T18015	cc	or,approaching
R4948	T18022	T18015	conj	entering,approaching
R4949	T18023	T18022	dobj	apoptosis,entering
R4950	T18024	T18025	punct	[,59
R4951	T18025	T18001	parataxis	59,localizes
R4952	T18026	T18025	punct	],59
R4953	T18027	T18001	punct	.,localizes
R4954	T18029	T18030	nsubj	We,observe
R4955	T18031	T18030	aux	did,observe
R4956	T18032	T18030	neg	not,observe
R4957	T18033	T18034	compound	sex,defects
R4958	T18034	T18030	dobj	defects,observe
R4959	T18035	T18034	compound	chromatin,defects
R4960	T18036	T18030	prep	prior,observe
R4961	T18037	T18036	prep	to,prior
R4962	T18038	T18037	pobj	diplonema,to
R4963	T18039	T18030	punct	", ",observe
R4964	T18040	T18030	cc	but,observe
R4965	T18041	T18042	nsubj	we,exclude
R4966	T18042	T18030	conj	exclude,observe
R4967	T18043	T18042	aux	can,exclude
R4968	T18044	T18042	neg	not,exclude
R4969	T18045	T18046	det	the,possibility
R4970	T18046	T18042	dobj	possibility,exclude
R4971	T18047	T18048	mark	that,exist
R4972	T18048	T18046	acl	exist,possibility
R4973	T18049	T18050	amod	earlier,defects
R4974	T18050	T18048	nsubj	defects,exist
R4975	T18051	T18048	cc	and,exist
R4976	T18052	T18053	det	the,cells
R4977	T18053	T18055	nsubjpass	cells,eliminated
R4978	T18054	T18053	amod	affected,cells
R4979	T18055	T18048	conj	eliminated,exist
R4980	T18056	T18055	auxpass	are,eliminated
R4981	T18057	T18055	advmod	rapidly,eliminated
R4982	T18058	T18042	punct	.,exclude
R4983	T18060	T18061	prep	In,staged
R4984	T18062	T18063	det	the,experiments
R4985	T18063	T18060	pobj	experiments,In
R4986	T18064	T18063	amod	preceding,experiments
R4987	T18065	T18061	punct	", ",staged
R4988	T18066	T18061	nsubj	we,staged
R4989	T18067	T18061	dobj	cells,staged
R4990	T18068	T18061	prep	based,staged
R4991	T18069	T18068	prep	on,based
R4992	T18070	T18071	compound	XY,body
R4993	T18071	T18072	compound	body,internalization
R4994	T18072	T18069	pobj	internalization,on
R4995	T18073	T18061	punct	.,staged
R4996	T18075	T18076	mark	Because,be
R4997	T18076	T18080	advcl	be,staged
R4998	T18077	T18078	det	this,process
R4999	T18078	T18076	nsubj	process,be
R5000	T18079	T18076	aux	could,be
R5001	T18081	T18076	acomp	abnormal,be
R5002	T18082	T18076	prep	in,be
R5003	T18083	T18084	det	the,cells
R5004	T18084	T18082	pobj	cells,in
R5005	T18085	T18084	compound	mutant,cells
R5006	T18086	T18080	punct	", ",staged
R5007	T18087	T18080	nsubj	we,staged
R5008	T18088	T18080	advmod	also,staged
R5009	T18089	T18090	compound	mutant,cells
R5010	T18090	T18080	dobj	cells,staged
R5011	T18091	T18080	prep	by,staged
R5012	T18092	T18093	compound	chromosome,morphology
R5013	T18093	T18091	pobj	morphology,by
R5014	T18094	T18080	advcl	using,staged
R5015	T18095	T18096	det	an,antibody
R5016	T18096	T18094	dobj	antibody,using
R5017	T18097	T18094	prep	to,using
R5018	T18098	T18097	pobj	SYCP3,to
R5019	T18099	T18100	punct	(,Figure
R5020	T18100	T18080	parataxis	Figure,staged
R5021	T18101	T18100	nummod	9,Figure
R5022	T18102	T18100	punct	),Figure
R5023	T18103	T18080	punct	.,staged
R5024	T18105	T18106	nsubj	This,identified
R5025	T18107	T18106	advmod	independently,identified
R5026	T18108	T18109	compound	Dmrt7,mutant
R5027	T18109	T18110	compound	mutant,cells
R5028	T18110	T18106	dobj	cells,identified
R5029	T18111	T18110	compound	diplotene,cells
R5030	T18112	T18110	acl	lacking,cells
R5031	T18113	T18114	compound	HP1β,accumulation
R5032	T18114	T18112	dobj	accumulation,lacking
R5033	T18115	T18112	prep	in,lacking
R5034	T18116	T18117	det	the,body
R5035	T18117	T18115	pobj	body,in
R5036	T18118	T18117	compound	XY,body
R5037	T18119	T18110	punct	", ",cells
R5038	T18120	T18121	amod	such,as
R5039	T18121	T18110	prep	as,cells
R5040	T18122	T18123	det	the,example
R5041	T18123	T18121	pobj	example,as
R5042	T18124	T18123	prep	in,example
R5043	T18125	T18126	compound	Figure,9B
R5044	T18126	T18124	pobj	9B,in
R5045	T18127	T18106	punct	.,identified
R5046	T18129	T18130	prep	From,conclude
R5047	T18131	T18132	det	these,results
R5048	T18132	T18129	pobj	results,From
R5049	T18133	T18130	punct	", ",conclude
R5050	T18134	T18130	nsubj	we,conclude
R5051	T18135	T18136	mark	that,establish
R5052	T18136	T18130	ccomp	establish,conclude
R5053	T18137	T18138	compound	Dmrt7,cells
R5054	T18138	T18136	nsubj	cells,establish
R5055	T18139	T18138	compound	mutant,cells
R5056	T18140	T18141	det	a,body
R5057	T18141	T18136	dobj	body,establish
R5058	T18142	T18141	amod	normal,body
R5059	T18143	T18141	compound	XY,body
R5060	T18144	T18136	prep	in,establish
R5061	T18145	T18144	pobj	mid-pachynema,in
R5062	T18146	T18136	punct	", ",establish
R5063	T18147	T18136	cc	but,establish
R5064	T18148	T18149	advmod	then,have
R5065	T18149	T18136	conj	have,establish
R5066	T18150	T18151	amod	multiple,defects
R5067	T18151	T18149	dobj	defects,have
R5068	T18152	T18151	amod	epigenetic,defects
R5069	T18153	T18149	prep	in,have
R5070	T18154	T18155	det	the,transition
R5071	T18155	T18153	pobj	transition,in
R5072	T18156	T18155	compound	sex,transition
R5073	T18157	T18155	compound	chromatin,transition
R5074	T18158	T18155	prep	from,transition
R5075	T18159	T18158	pobj	pachynema,from
R5076	T18160	T18155	prep	to,transition
R5077	T18161	T18160	pobj	diplonema,to
R5078	T18162	T18130	punct	.,conclude
R5083	T21499	T21500	prep	In,find
R5084	T21501	T21502	det	this,study
R5085	T21502	T21499	pobj	study,In
R5086	T21503	T21500	punct	", ",find
R5087	T21504	T21500	nsubj	we,find
R5088	T21505	T21506	mark	that,required
R5089	T21506	T21500	ccomp	required,find
R5090	T21507	T21508	det	the,protein
R5091	T21508	T21506	nsubjpass	protein,required
R5092	T21509	T21510	compound	DM,domain
R5093	T21510	T21508	compound	domain,protein
R5094	T21511	T21508	appos	DMRT7,protein
R5095	T21512	T21506	auxpass	is,required
R5096	T21513	T21514	mark	for,complete
R5097	T21514	T21506	advcl	complete,required
R5098	T21515	T21516	amod	male,cells
R5099	T21516	T21514	nsubj	cells,complete
R5100	T21517	T21516	compound	germ,cells
R5101	T21518	T21514	aux	to,complete
R5102	T21519	T21520	amod	meiotic,prophase
R5103	T21520	T21514	dobj	prophase,complete
R5104	T21521	T21506	cc	but,required
R5105	T21522	T21506	conj	is,required
R5106	T21523	T21522	acomp	dispensable,is
R5107	T21524	T21522	prep	in,is
R5108	T21525	T21526	det	the,line
R5109	T21526	T21524	pobj	line,in
R5110	T21527	T21526	amod	female,line
R5111	T21528	T21526	compound	germ,line
R5112	T21529	T21500	punct	.,find
R5113	T21531	T21532	prep	In,is
R5114	T21533	T21531	pobj	males,In
R5115	T21534	T21532	punct	", ",is
R5116	T21535	T21536	compound	DMRT7,expression
R5117	T21536	T21532	nsubj	expression,is
R5118	T21537	T21532	acomp	highest,is
R5119	T21538	T21532	prep	in,is
R5120	T21539	T21540	compound	pachytene,spermatocytes
R5121	T21540	T21538	pobj	spermatocytes,in
R5122	T21541	T21532	punct	", ",is
R5123	T21542	T21532	cc	and,is
R5124	T21543	T21544	det	the,protein
R5125	T21544	T21545	nsubj	protein,localizes
R5126	T21545	T21532	conj	localizes,is
R5127	T21546	T21545	advmod	preferentially,localizes
R5128	T21547	T21545	prep	to,localizes
R5129	T21548	T21549	det	the,body
R5130	T21549	T21547	pobj	body,to
R5131	T21550	T21549	compound	XY,body
R5132	T21551	T21532	punct	.,is
R5133	T21553	T21554	advcl	Consistent,found
R5134	T21555	T21553	prep	with,Consistent
R5135	T21556	T21557	det	this,expression
R5136	T21557	T21555	pobj	expression,with
R5137	T21558	T21554	punct	", ",found
R5138	T21559	T21554	nsubj	we,found
R5139	T21560	T21561	mark	that,arrest
R5140	T21561	T21554	ccomp	arrest,found
R5141	T21562	T21563	amod	most,cells
R5142	T21563	T21561	nsubj	cells,arrest
R5143	T21564	T21563	nmod	mutant,cells
R5144	T21565	T21563	amod	male,cells
R5145	T21566	T21563	compound	germ,cells
R5146	T21567	T21561	prep	in,arrest
R5147	T21568	T21567	pobj	pachynema,in
R5148	T21569	T21561	cc	and,arrest
R5149	T21570	T21561	conj	undergo,arrest
R5150	T21571	T21570	dobj	apoptosis,undergo
R5151	T21572	T21561	punct	", ",arrest
R5152	T21573	T21574	mark	although,progress
R5153	T21574	T21561	advcl	progress,arrest
R5154	T21575	T21576	det	a,proportion
R5155	T21576	T21574	nsubj	proportion,progress
R5156	T21577	T21576	amod	small,proportion
R5157	T21578	T21574	aux	can,progress
R5158	T21579	T21574	prep	to,progress
R5159	T21580	T21579	pobj	diplonema,to
R5160	T21581	T21579	cc	and,to
R5161	T21582	T21583	advmod	sometimes,beyond
R5162	T21583	T21579	conj	beyond,to
R5163	T21584	T21554	punct	.,found
R5164	T21586	T21587	nsubj	Examination,revealed
R5165	T21588	T21586	prep	of,Examination
R5166	T21589	T21588	pobj	chromatin,of
R5167	T21590	T21589	cc	and,chromatin
R5168	T21591	T21592	amod	nascent,transcription
R5169	T21592	T21589	conj	transcription,chromatin
R5170	T21593	T21586	prep	in,Examination
R5171	T21594	T21595	compound	mutant,cells
R5172	T21595	T21593	pobj	cells,in
R5173	T21596	T21597	dep	that,progressed
R5174	T21597	T21595	relcl	progressed,cells
R5175	T21598	T21597	prep	to,progressed
R5176	T21599	T21598	pobj	diplonema,to
R5177	T21600	T21601	compound	sex,chromatin
R5178	T21601	T21602	compound	chromatin,abnormalities
R5179	T21602	T21587	dobj	abnormalities,revealed
R5180	T21603	T21587	punct	", ",revealed
R5181	T21604	T21605	mark	as,discussed
R5182	T21605	T21587	advcl	discussed,revealed
R5183	T21606	T21605	advmod	below,discussed
R5184	T21607	T21587	punct	.,revealed
R5185	T21609	T21610	det	The,stage
R5186	T21610	T21612	nsubj	stage,involves
R5187	T21611	T21610	compound	pachytene,stage
R5188	T21613	T21610	prep	of,stage
R5189	T21614	T21613	pobj	prophase,of
R5190	T21615	T21616	amod	tremendous,changes
R5191	T21616	T21612	dobj	changes,involves
R5192	T21617	T21616	amod	chromosomal,changes
R5193	T21618	T21619	mark	as,align
R5194	T21619	T21612	advcl	align,involves
R5195	T21620	T21621	det	the,homologs
R5196	T21621	T21619	nsubj	homologs,align
R5197	T21622	T21619	punct	", ",align
R5198	T21623	T21619	conj	synapse,align
R5199	T21624	T21623	punct	", ",synapse
R5200	T21625	T21623	cc	and,synapse
R5201	T21626	T21623	conj	recombine,synapse
R5202	T21627	T21612	punct	.,involves
R5203	T21629	T21630	prep	During,exists
R5204	T21631	T21632	det	this,period
R5205	T21632	T21629	pobj	period,During
R5206	T21633	T21630	punct	", ",exists
R5207	T21634	T21635	advmod	at,one
R5208	T21635	T21637	nummod	one,system
R5209	T21636	T21635	advmod	least,one
R5210	T21637	T21630	nsubj	system,exists
R5211	T21638	T21637	compound	pachytene,system
R5212	T21639	T21637	compound	surveillance,system
R5213	T21640	T21641	aux	to,monitor
R5214	T21641	T21630	advcl	monitor,exists
R5215	T21642	T21643	amod	key,events
R5216	T21643	T21641	dobj	events,monitor
R5217	T21644	T21643	prep	of,events
R5218	T21645	T21646	amod	meiotic,progression
R5219	T21646	T21644	pobj	progression,of
R5220	T21647	T21630	punct	.,exists
R5221	T21649	T21650	nsubjpass	Cells,eliminated
R5222	T21651	T21652	prep	in,is
R5223	T21652	T21649	relcl	is,Cells
R5224	T21653	T21651	pobj	which,in
R5225	T21654	T21652	nsubj	any,is
R5226	T21655	T21654	prep	of,any
R5227	T21656	T21657	det	these,events
R5228	T21657	T21655	pobj	events,of
R5229	T21658	T21652	acomp	anomalous,is
R5230	T21659	T21650	auxpass	are,eliminated
R5231	T21660	T21650	advmod	efficiently,eliminated
R5232	T21661	T21650	agent	by,eliminated
R5233	T21662	T21661	pobj	apoptosis,by
R5234	T21663	T21664	punct	[,46
R5235	T21664	T21650	parataxis	46,eliminated
R5236	T21665	T21664	punct	],46
R5237	T21666	T21650	punct	.,eliminated
R5238	T21668	T21669	det	Another,event
R5239	T21669	T21671	nsubj	event,is
R5240	T21670	T21669	amod	key,event
R5241	T21672	T21669	prep	of,event
R5242	T21673	T21672	pobj	pachynema,of
R5243	T21674	T21669	prep	in,event
R5244	T21675	T21676	amod	male,mammals
R5245	T21676	T21674	pobj	mammals,in
R5246	T21677	T21678	det	the,packaging
R5247	T21678	T21671	attr	packaging,is
R5248	T21679	T21678	prep	of,packaging
R5249	T21680	T21681	det	the,chromosomes
R5250	T21681	T21679	pobj	chromosomes,of
R5251	T21682	T21681	compound	sex,chromosomes
R5252	T21683	T21678	prep	into,packaging
R5253	T21684	T21685	det	the,body
R5254	T21685	T21683	pobj	body,into
R5255	T21686	T21685	compound	XY,body
R5256	T21687	T21678	cc	and,packaging
R5257	T21688	T21689	det	the,establishment
R5258	T21689	T21678	conj	establishment,packaging
R5259	T21690	T21689	prep	of,establishment
R5260	T21691	T21690	pobj	MSCI,of
R5261	T21692	T21671	punct	.,is
R5262	T21694	T21695	nsubj	Examination,showed
R5263	T21696	T21694	prep	of,Examination
R5264	T21697	T21698	amod	male,meiosis
R5265	T21698	T21696	pobj	meiosis,of
R5266	T21699	T21694	prep	in,Examination
R5267	T21700	T21701	compound	XYY,mice
R5268	T21701	T21699	pobj	mice,in
R5269	T21702	T21701	cc	and,mice
R5270	T21703	T21701	conj	mice,mice
R5271	T21704	T21703	acl	carrying,mice
R5272	T21705	T21706	det	a,translocation
R5273	T21706	T21704	dobj	translocation,carrying
R5274	T21707	T21708	nmod	sex,chromosome
R5275	T21708	T21706	nmod	chromosome,translocation
R5276	T21709	T21708	punct	-,chromosome
R5277	T21710	T21708	punct	-,chromosome
R5278	T21711	T21708	prep	to,chromosome
R5279	T21712	T21711	punct	-,to
R5280	T21713	T21711	pobj	autosome,to
R5281	T21714	T21715	mark	that,eliminated
R5282	T21715	T21695	ccomp	eliminated,showed
R5283	T21716	T21715	nsubjpass	cells,eliminated
R5284	T21717	T21718	prep	in,escapes
R5285	T21718	T21716	relcl	escapes,cells
R5286	T21719	T21717	pobj	which,in
R5287	T21720	T21721	det	a,chromosome
R5288	T21721	T21718	nsubj	chromosome,escapes
R5289	T21722	T21721	compound	sex,chromosome
R5290	T21723	T21718	dobj	MSCI,escapes
R5291	T21724	T21715	auxpass	are,eliminated
R5292	T21725	T21715	prep	prior,eliminated
R5293	T21726	T21725	prep	to,prior
R5294	T21727	T21728	amod	late,pachynema
R5295	T21728	T21726	pobj	pachynema,to
R5296	T21729	T21728	punct	-,pachynema
R5297	T21730	T21731	punct	[,17
R5298	T21731	T21695	parataxis	17,showed
R5299	T21732	T21731	punct	],17
R5300	T21733	T21695	punct	.,showed
R5301	T21735	T21736	nsubj	This,indicates
R5302	T21737	T21738	mark	that,is
R5303	T21738	T21736	ccomp	is,indicates
R5304	T21739	T21740	det	the,establishment
R5305	T21740	T21738	nsubj	establishment,is
R5306	T21741	T21740	prep	of,establishment
R5307	T21742	T21741	pobj	MSCI,of
R5308	T21743	T21738	advmod	also,is
R5309	T21744	T21738	acomp	subject,is
R5310	T21745	T21744	prep	to,subject
R5311	T21746	T21745	pobj	surveillance,to
R5312	T21747	T21736	punct	.,indicates
R5313	T21749	T21750	mark	Since,result
R5314	T21750	T21760	advcl	result,tested
R5315	T21751	T21752	det	the,arrest
R5316	T21752	T21750	nsubj	arrest,result
R5317	T21753	T21752	cc	and,arrest
R5318	T21754	T21752	conj	apoptosis,arrest
R5319	T21755	T21752	prep	of,arrest
R5320	T21756	T21757	compound	Dmrt7,mutant
R5321	T21757	T21758	compound	mutant,spermatocytes
R5322	T21758	T21755	pobj	spermatocytes,of
R5323	T21759	T21750	aux	could,result
R5324	T21761	T21750	prep	from,result
R5325	T21762	T21761	pobj	perturbation,from
R5326	T21763	T21762	prep	of,perturbation
R5327	T21764	T21763	pobj	any,of
R5328	T21765	T21764	prep	of,any
R5329	T21766	T21767	det	the,events
R5330	T21767	T21765	pobj	events,of
R5331	T21768	T21767	amod	critical,events
R5332	T21769	T21767	compound	pachytene,events
R5333	T21770	T21767	acl	mentioned,events
R5334	T21771	T21770	advmod	above,mentioned
R5335	T21772	T21760	punct	", ",tested
R5336	T21773	T21760	nsubj	we,tested
R5337	T21774	T21775	mark	whether,occur
R5338	T21775	T21760	ccomp	occur,tested
R5339	T21776	T21775	nsubj	they,occur
R5340	T21777	T21775	advmod	abnormally,occur
R5341	T21778	T21775	prep	in,occur
R5342	T21779	T21780	det	the,cells
R5343	T21780	T21778	pobj	cells,in
R5344	T21781	T21780	compound	mutant,cells
R5345	T21782	T21760	punct	.,tested
R5346	T21784	T21785	nsubj	We,found
R5347	T21786	T21787	mark	that,appear
R5348	T21787	T21785	ccomp	appear,found
R5349	T21788	T21789	amod	chromosomal,synapsis
R5350	T21789	T21787	nsubj	synapsis,appear
R5351	T21790	T21789	cc	and,synapsis
R5352	T21791	T21789	conj	recombination,synapsis
R5353	T21792	T21787	oprd	normal,appear
R5354	T21793	T21787	prep	in,appear
R5355	T21794	T21795	compound	Dmrt7,mutant
R5356	T21795	T21796	compound	mutant,cells
R5357	T21796	T21793	pobj	cells,in
R5358	T21797	T21785	punct	.,found
R5359	T21799	T21800	nsubj	We,focused
R5360	T21801	T21800	advmod	therefore,focused
R5361	T21802	T21800	prep	on,focused
R5362	T21803	T21804	det	the,body
R5363	T21804	T21802	pobj	body,on
R5364	T21805	T21804	compound	XY,body
R5365	T21806	T21804	punct	", ",body
R5366	T21807	T21808	det	the,site
R5367	T21808	T21804	appos	site,body
R5368	T21809	T21810	advmod	most,prominent
R5369	T21810	T21808	amod	prominent,site
R5370	T21811	T21808	prep	of,site
R5371	T21812	T21813	compound	DMRT7,accumulation
R5372	T21813	T21811	pobj	accumulation,of
R5373	T21814	T21800	punct	.,focused
R5374	T21816	T21817	advmod	First,tested
R5375	T21818	T21817	punct	", ",tested
R5376	T21819	T21817	nsubj	we,tested
R5377	T21820	T21821	mark	whether,forms
R5378	T21821	T21817	ccomp	forms,tested
R5379	T21822	T21823	det	the,body
R5380	T21823	T21821	nsubj	body,forms
R5381	T21824	T21823	compound	XY,body
R5382	T21825	T21821	cc	and,forms
R5383	T21826	T21827	nsubjpass	MSCI,established
R5384	T21827	T21821	conj	established,forms
R5385	T21828	T21827	auxpass	is,established
R5386	T21829	T21821	prep	in,forms
R5387	T21830	T21831	compound	Dmrt7,mutant
R5388	T21831	T21832	compound	mutant,cells
R5389	T21832	T21829	pobj	cells,in
R5390	T21833	T21817	punct	.,tested
R5391	T21835	T21836	advmod	Surprisingly,found
R5392	T21837	T21836	punct	", ",found
R5393	T21838	T21836	nsubj	we,found
R5394	T21839	T21840	mark	that,form
R5395	T21840	T21836	ccomp	form,found
R5396	T21841	T21842	det	these,cells
R5397	T21842	T21840	nsubj	cells,form
R5398	T21843	T21844	det	an,body
R5399	T21844	T21840	dobj	body,form
R5400	T21845	T21844	compound	XY,body
R5401	T21846	T21844	prep	with,body
R5402	T21847	T21848	amod	normal,morphology
R5403	T21848	T21846	pobj	morphology,with
R5404	T21849	T21848	cc	and,morphology
R5405	T21850	T21851	amod	proper,accumulation
R5406	T21851	T21848	conj	accumulation,morphology
R5407	T21852	T21851	prep	of,accumulation
R5408	T21853	T21854	predet	all,marks
R5409	T21854	T21852	pobj	marks,of
R5410	T21855	T21854	det	the,marks
R5411	T21856	T21854	compound	chromatin,marks
R5412	T21857	T21858	nsubj	we,examined
R5413	T21858	T21854	advcl	examined,marks
R5414	T21859	T21836	punct	.,found
R5415	T21861	T21862	advmod	Moreover,demonstrated
R5416	T21863	T21862	punct	", ",demonstrated
R5417	T21864	T21865	nmod	Cot,hybridization
R5418	T21865	T21862	nsubj	hybridization,demonstrated
R5419	T21866	T21864	punct	-,Cot
R5420	T21867	T21864	nummod	1,Cot
R5421	T21868	T21865	cc	and,hybridization
R5422	T21869	T21865	conj	analysis,hybridization
R5423	T21870	T21869	prep	of,analysis
R5424	T21871	T21872	compound	RBMY,expression
R5425	T21872	T21870	pobj	expression,of
R5426	T21873	T21874	mark	that,initiates
R5427	T21874	T21862	ccomp	initiates,demonstrated
R5428	T21875	T21874	nsubj	MSCI,initiates
R5429	T21876	T21874	advmod	normally,initiates
R5430	T21877	T21874	prep	in,initiates
R5431	T21878	T21879	det	the,body
R5432	T21879	T21877	pobj	body,in
R5433	T21880	T21879	compound	XY,body
R5434	T21881	T21879	prep	of,body
R5435	T21882	T21883	compound	mid-pachytene,cells
R5436	T21883	T21881	pobj	cells,of
R5437	T21884	T21885	compound	Dmrt7,mutant
R5438	T21885	T21883	compound	mutant,cells
R5439	T21886	T21862	punct	.,demonstrated
R5440	T21888	T21889	nsubj	We,observe
R5441	T21890	T21889	aux	did,observe
R5442	T21891	T21889	punct	", ",observe
R5443	T21892	T21889	advmod	however,observe
R5444	T21893	T21889	punct	", ",observe
R5445	T21894	T21895	nummod	three,defects
R5446	T21895	T21889	dobj	defects,observe
R5447	T21896	T21895	amod	specific,defects
R5448	T21897	T21889	prep	in,observe
R5449	T21898	T21899	det	the,chromatin
R5450	T21899	T21897	pobj	chromatin,in
R5451	T21900	T21899	compound	sex,chromatin
R5452	T21901	T21899	prep	of,chromatin
R5453	T21902	T21903	compound	Dmrt7,mutant
R5454	T21903	T21904	compound	mutant,cells
R5455	T21904	T21901	pobj	cells,of
R5456	T21905	T21904	compound	germ,cells
R5457	T21906	T21907	dep	that,avoided
R5458	T21907	T21904	relcl	avoided,cells
R5459	T21908	T21907	dobj	arrest,avoided
R5460	T21909	T21908	prep	in,arrest
R5461	T21910	T21909	pobj	pachynema,in
R5462	T21911	T21907	cc	and,avoided
R5463	T21912	T21907	conj	were,avoided
R5464	T21913	T21912	acomp	able,were
R5465	T21914	T21915	aux	to,enter
R5466	T21915	T21913	xcomp	enter,able
R5467	T21916	T21915	dobj	diplonema,enter
R5468	T21917	T21889	punct	.,observe
R5469	T21919	T21920	advmod	Normally,accumulate
R5470	T21921	T21920	nsubj	cells,accumulate
R5471	T21922	T21923	nmod	H3,2meK9
R5472	T21923	T21925	nmod	2meK9,marks
R5473	T21924	T21923	punct	-,2meK9
R5474	T21925	T21920	dobj	marks,accumulate
R5475	T21926	T21923	cc	and,2meK9
R5476	T21927	T21928	compound	H3,3meK9
R5477	T21928	T21923	conj	3meK9,2meK9
R5478	T21929	T21928	punct	-,3meK9
R5479	T21930	T21925	cc	and,marks
R5480	T21931	T21932	compound	HP1β,protein
R5481	T21932	T21925	conj	protein,marks
R5482	T21933	T21920	prep	on,accumulate
R5483	T21934	T21935	det	the,chromatin
R5484	T21935	T21933	pobj	chromatin,on
R5485	T21936	T21935	compound	sex,chromatin
R5486	T21937	T21938	mark	as,progress
R5487	T21938	T21920	advcl	progress,accumulate
R5488	T21939	T21938	nsubj	they,progress
R5489	T21940	T21938	prep	to,progress
R5490	T21941	T21940	pobj	diplonema,to
R5491	T21942	T21920	punct	", ",accumulate
R5492	T21943	T21920	cc	but,accumulate
R5493	T21944	T21945	nsubj	we,observed
R5494	T21945	T21920	conj	observed,accumulate
R5495	T21946	T21947	compound	mutant,cells
R5496	T21947	T21945	dobj	cells,observed
R5497	T21948	T21947	compound	diplotene,cells
R5498	T21949	T21947	acl	lacking,cells
R5499	T21950	T21951	det	these,features
R5500	T21951	T21949	dobj	features,lacking
R5501	T21952	T21945	punct	.,observed
R5502	T21954	T21955	advmod	Thus,are
R5503	T21956	T21955	punct	", ",are
R5504	T21957	T21958	mark	although,progress
R5505	T21958	T21955	advcl	progress,are
R5506	T21959	T21960	det	a,minority
R5507	T21960	T21958	nsubj	minority,progress
R5508	T21961	T21960	prep	of,minority
R5509	T21962	T21963	compound	Dmrt7,mutant
R5510	T21963	T21964	compound	mutant,cells
R5511	T21964	T21961	pobj	cells,of
R5512	T21965	T21964	compound	germ,cells
R5513	T21966	T21958	aux	can,progress
R5514	T21967	T21958	prep	from,progress
R5515	T21968	T21967	pobj	pachynema,from
R5516	T21969	T21958	prep	to,progress
R5517	T21970	T21969	pobj	diplonema,to
R5518	T21971	T21955	punct	", ",are
R5519	T21972	T21955	expl	there,are
R5520	T21973	T21955	attr	defects,are
R5521	T21974	T21973	prep	in,defects
R5522	T21975	T21976	compound	sex,chromatin
R5523	T21976	T21977	compound	chromatin,modification
R5524	T21977	T21974	pobj	modification,in
R5525	T21978	T21955	prep	during,are
R5526	T21979	T21980	det	the,transition
R5527	T21980	T21978	pobj	transition,during
R5528	T21981	T21955	punct	.,are
R5529	T21983	T21984	det	A,function
R5530	T21984	T21985	nsubj	function,reconcile
R5531	T21986	T21984	prep	in,function
R5532	T21987	T21988	amod	male,chromatin
R5533	T21988	T21986	pobj	chromatin,in
R5534	T21989	T21988	compound	sex,chromatin
R5535	T21990	T21985	aux	can,reconcile
R5536	T21991	T21992	det	the,findings
R5537	T21992	T21985	dobj	findings,reconcile
R5538	T21993	T21994	mark	that,required
R5539	T21994	T21992	acl	required,findings
R5540	T21995	T21994	nsubjpass	DMRT7,required
R5541	T21996	T21994	auxpass	is,required
R5542	T21997	T21994	prep	for,required
R5543	T21998	T21997	pobj	meiosis,for
R5544	T21999	T21994	punct	", ",required
R5545	T22000	T21994	cc	but,required
R5546	T22001	T22002	advmod	only,in
R5547	T22002	T22000	prep	in,but
R5548	T22003	T22002	pobj	males,in
R5549	T22004	T21985	punct	", ",reconcile
R5550	T22005	T21985	cc	and,reconcile
R5551	T22006	T21985	conj	is,reconcile
R5552	T22007	T22006	acomp	present,is
R5553	T22008	T22009	advmod	only,in
R5554	T22009	T22006	prep	in,is
R5555	T22010	T22009	pobj	mammals,in
R5556	T22011	T21985	punct	.,reconcile
R5557	T22013	T22014	det	A,proportion
R5558	T22014	T22015	nsubj	proportion,have
R5559	T22015	T22020	ccomp	have,are
R5560	T22016	T22014	prep	of,proportion
R5561	T22017	T22018	compound	mutant,cells
R5562	T22018	T22016	pobj	cells,of
R5563	T22019	T22018	compound	diplotene,cells
R5564	T22021	T22022	advmod	apparently,normal
R5565	T22022	T22023	amod	normal,chromatin
R5566	T22023	T22015	dobj	chromatin,have
R5567	T22024	T22023	compound	sex,chromatin
R5568	T22025	T22026	punct	(,8M
R5569	T22026	T22015	parataxis	8M,have
R5570	T22027	T22026	prep	for,8M
R5571	T22028	T22027	pobj	example,for
R5572	T22029	T22026	punct	", ",8M
R5573	T22030	T22026	compound	Figure,8M
R5574	T22031	T22026	punct	),8M
R5575	T22032	T22020	punct	;,are
R5576	T22033	T22020	nsubj	these,are
R5577	T22034	T22020	acomp	likely,are
R5578	T22035	T22036	aux	to,be
R5579	T22036	T22034	xcomp	be,likely
R5580	T22037	T22038	det	the,cells
R5581	T22038	T22036	attr	cells,be
R5582	T22039	T22040	dep	that,progress
R5583	T22040	T22038	relcl	progress,cells
R5584	T22041	T22040	aux	can,progress
R5585	T22042	T22040	prep	beyond,progress
R5586	T22043	T22042	pobj	diplonema,beyond
R5587	T22044	T22020	punct	.,are
R5588	T22046	T22047	mark	Because,eliminated
R5589	T22047	T22054	advcl	eliminated,is
R5590	T22048	T22049	amod	most,cells
R5591	T22049	T22047	nsubjpass	cells,eliminated
R5592	T22050	T22051	compound	Dmrt7,mutant
R5593	T22051	T22049	compound	mutant,cells
R5594	T22052	T22049	compound	germ,cells
R5595	T22053	T22047	auxpass	are,eliminated
R5596	T22055	T22047	agent	by,eliminated
R5597	T22056	T22055	pobj	apoptosis,by
R5598	T22057	T22047	prep	around,eliminated
R5599	T22058	T22059	det	the,time
R5600	T22059	T22057	pobj	time,around
R5601	T22060	T22061	prep	at,observed
R5602	T22061	T22059	relcl	observed,time
R5603	T22062	T22060	pobj	which,at
R5604	T22063	T22061	nsubj	we,observed
R5605	T22064	T22065	compound	sex,defects
R5606	T22065	T22061	dobj	defects,observed
R5607	T22066	T22065	compound	chromatin,defects
R5608	T22067	T22054	punct	", ",is
R5609	T22068	T22069	det	a,model
R5610	T22069	T22054	nsubj	model,is
R5611	T22070	T22069	amod	simple,model
R5612	T22071	T22072	mark	that,is
R5613	T22072	T22054	ccomp	is,is
R5614	T22073	T22074	det	the,apoptosis
R5615	T22074	T22072	nsubj	apoptosis,is
R5616	T22075	T22076	det	a,consequence
R5617	T22076	T22072	attr	consequence,is
R5618	T22077	T22076	prep	of,consequence
R5619	T22078	T22079	det	the,defects
R5620	T22079	T22077	pobj	defects,of
R5621	T22080	T22081	compound	sex,chromatin
R5622	T22081	T22079	compound	chromatin,defects
R5623	T22082	T22054	punct	.,is
R5624	T22084	T22085	det	The,situation
R5625	T22085	T22087	nsubj	situation,is
R5626	T22086	T22085	amod	reciprocal,situation
R5627	T22088	T22089	punct	(,defects
R5628	T22089	T22085	parataxis	defects,situation
R5629	T22090	T22089	compound	sex,defects
R5630	T22091	T22089	compound	chromatin,defects
R5631	T22092	T22089	acl	caused,defects
R5632	T22093	T22092	agent	by,caused
R5633	T22094	T22093	pobj	apoptosis,by
R5634	T22095	T22089	punct	),defects
R5635	T22096	T22087	acomp	possible,is
R5636	T22097	T22087	punct	", ",is
R5637	T22098	T22087	cc	but,is
R5638	T22099	T22087	conj	seems,is
R5639	T22100	T22099	oprd	unlikely,seems
R5640	T22101	T22087	punct	", ",is
R5641	T22102	T22103	mark	because,observed
R5642	T22103	T22087	advcl	observed,is
R5643	T22104	T22103	nsubj	we,observed
R5644	T22105	T22106	compound	mutant,cells
R5645	T22106	T22103	dobj	cells,observed
R5646	T22107	T22106	prep	with,cells
R5647	T22108	T22109	compound	sex,chromatin
R5648	T22109	T22110	compound	chromatin,defects
R5649	T22110	T22107	pobj	defects,with
R5650	T22111	T22110	cc	but,defects
R5651	T22112	T22113	det	no,indications
R5652	T22113	T22110	conj	indications,defects
R5653	T22114	T22113	prep	of,indications
R5654	T22115	T22114	pobj	apoptosis,of
R5655	T22116	T22087	punct	.,is
R5656	T22118	T22119	advmod	Alternatively,be
R5657	T22120	T22119	punct	", ",be
R5658	T22121	T22119	nsubj	apoptosis,be
R5659	T22122	T22121	cc	and,apoptosis
R5660	T22123	T22124	amod	abnormal,chromatin
R5661	T22124	T22121	conj	chromatin,apoptosis
R5662	T22125	T22124	compound	sex,chromatin
R5663	T22126	T22119	aux	may,be
R5664	T22127	T22128	nummod	two,consequences
R5665	T22128	T22119	attr	consequences,be
R5666	T22129	T22128	amod	independent,consequences
R5667	T22130	T22128	prep	of,consequences
R5668	T22131	T22132	compound	Dmrt7,loss
R5669	T22132	T22130	pobj	loss,of
R5670	T22133	T22119	punct	.,be
R5671	T22135	T22136	det	This,question
R5672	T22136	T22137	nsubjpass	question,answered
R5673	T22138	T22137	aux	can,answered
R5674	T22394	T22374	punct	", ",required
R5675	T22139	T22137	neg	not,answered
R5676	T22395	T22374	cc	but,required
R5677	T22396	T22397	nsubjpass	it,expressed
R5678	T22140	T22137	auxpass	be,answered
R5679	T22397	T22374	conj	expressed,required
R5680	T22398	T22397	auxpass	is,expressed
R5681	T22141	T22137	advmod	definitively,answered
R5682	T22399	T22397	neg	not,expressed
R5683	T22400	T22397	prep	in,expressed
R5684	T22401	T22402	amod	meiotic,cells
R5685	T22142	T22143	mark	until,know
R5686	T22402	T22400	pobj	cells,in
R5687	T22403	T22404	punct	[,31
R5688	T22404	T22397	parataxis	31,expressed
R5689	T22143	T22137	advcl	know,answered
R5690	T22405	T22404	punct	],31
R5691	T22406	T22407	punct	(,S.
R5692	T22407	T22397	meta	S.,expressed
R5693	T22144	T22143	nsubj	we,know
R5694	T22408	T22407	nmod	Kim,S.
R5695	T22409	T22407	cc	and,S.
R5696	T22410	T22407	conj	D.,S.
R5697	T22145	T22146	det	the,mechanism
R5698	T22411	T22410	nmod	Zarkower,D.
R5699	T22412	T22410	punct	", ",D.
R5700	T22146	T22143	dobj	mechanism,know
R5701	T22413	T22414	amod	unpublished,data
R5702	T22414	T22410	conj	data,D.
R5703	T22415	T22414	punct	),data
R5704	T22147	T22146	amod	detailed,mechanism
R5705	T22416	T22397	punct	.,expressed
R5706	T22418	T22419	det	The,requirement
R5707	T22148	T22146	amod	molecular,mechanism
R5708	T22419	T22420	nsubj	requirement,demonstrates
R5709	T22149	T22146	prep	of,mechanism
R5710	T22421	T22419	prep	for,requirement
R5711	T22422	T22421	pobj	DMRT1,for
R5712	T22423	T22422	prep	in,DMRT1
R5713	T22424	T22425	amod	pre-meiotic,cells
R5714	T22425	T22423	pobj	cells,in
R5715	T22150	T22149	pobj	DMRT7,of
R5716	T22426	T22425	compound	germ,cells
R5717	T22427	T22422	cc	and,DMRT1
R5718	T22428	T22422	conj	DMRT7,DMRT1
R5719	T22151	T22137	punct	.,answered
R5720	T22429	T22428	prep	in,DMRT7
R5721	T22430	T22431	amod	meiotic,cells
R5722	T22431	T22429	pobj	cells,in
R5723	T22153	T22154	det	A,number
R5724	T22432	T22431	compound	germ,cells
R5725	T22433	T22434	mark	that,act
R5726	T22434	T22420	ccomp	act,demonstrates
R5727	T22435	T22436	compound	DM,domain
R5728	T22154	T22155	nsubjpass	number,identified
R5729	T22436	T22437	compound	domain,proteins
R5730	T22437	T22434	nsubj	proteins,act
R5731	T22438	T22434	prep	at,act
R5732	T22156	T22154	prep	of,number
R5733	T22439	T22440	amod	multiple,points
R5734	T22157	T22158	amod	other,proteins
R5735	T22440	T22438	pobj	points,at
R5736	T22441	T22440	amod	critical,points
R5737	T22158	T22156	pobj	proteins,of
R5738	T22442	T22440	prep	of,points
R5739	T22443	T22444	amod	male,development
R5740	T22159	T22155	aux	have,identified
R5741	T22160	T22155	auxpass	been,identified
R5742	T22444	T22442	pobj	development,of
R5743	T22161	T22162	dep	that,interact
R5744	T22162	T22155	ccomp	interact,identified
R5745	T22445	T22446	compound	germ,cell
R5746	T22163	T22162	prep	with,interact
R5747	T22164	T22165	det	the,body
R5748	T22446	T22444	compound	cell,development
R5749	T22447	T22420	punct	.,demonstrates
R5750	T22165	T22163	pobj	body,with
R5751	T22449	T22450	nsubj	Ovaries,have
R5752	T22166	T22165	compound	XY,body
R5753	T22451	T22449	prep	of,Ovaries
R5754	T22167	T22155	punct	", ",identified
R5755	T22452	T22453	compound	Dmrt4,females
R5756	T22453	T22451	pobj	females,of
R5757	T22168	T22155	prep	including,identified
R5758	T22454	T22453	compound	mutant,females
R5759	T22455	T22456	amod	polyovular,follicles
R5760	T22169	T22170	compound	histone,variants
R5761	T22456	T22450	dobj	follicles,have
R5762	T22170	T22168	pobj	variants,including
R5763	T22457	T22456	punct	(,follicles
R5764	T22171	T22170	cc	and,variants
R5765	T22458	T22456	appos	follicles,follicles
R5766	T22459	T22458	acl	containing,follicles
R5767	T22460	T22461	amod	multiple,oocytes
R5768	T22172	T22173	amod	modified,histones
R5769	T22461	T22459	dobj	oocytes,containing
R5770	T22462	T22456	punct	),follicles
R5771	T22173	T22170	conj	histones,variants
R5772	T22463	T22450	punct	", ",have
R5773	T22464	T22450	cc	but,have
R5774	T22465	T22466	nsubj	it,is
R5775	T22174	T22173	punct	", ",histones
R5776	T22466	T22450	conj	is,have
R5777	T22175	T22176	det	a,transferase
R5778	T22467	T22466	acomp	unknown,is
R5779	T22176	T22173	conj	transferase,histones
R5780	T22468	T22469	mark	whether,reflects
R5781	T22469	T22466	ccomp	reflects,is
R5782	T22470	T22469	nsubj	this,reflects
R5783	T22177	T22178	npadvmod	testis,specific
R5784	T22471	T22472	det	a,defect
R5785	T22472	T22469	dobj	defect,reflects
R5786	T22178	T22176	amod	specific,transferase
R5787	T22473	T22472	prep	in,defect
R5788	T22474	T22475	det	the,line
R5789	T22179	T22178	punct	-,specific
R5790	T22475	T22473	pobj	line,in
R5791	T22476	T22475	compound	germ,line
R5792	T22180	T22176	compound	histone,transferase
R5793	T22477	T22475	cc	or,line
R5794	T22478	T22479	det	the,soma
R5795	T22181	T22176	compound	methyl,transferase
R5796	T22479	T22475	conj	soma,line
R5797	T22480	T22466	punct	.,is
R5798	T22182	T22176	punct	", ",transferase
R5799	T22482	T22483	nsubj	It,is
R5800	T22183	T22184	compound	chromobox,proteins
R5801	T22484	T22483	acomp	notable,is
R5802	T22485	T22486	mark	that,affect
R5803	T22184	T22176	conj	proteins,transferase
R5804	T22486	T22483	ccomp	affect,is
R5805	T22487	T22488	advmod	at,three
R5806	T22185	T22184	punct	", ",proteins
R5807	T22488	T22490	nummod	three,genes
R5808	T22489	T22488	advmod	least,three
R5809	T22186	T22187	det	an,factor
R5810	T22187	T22184	conj	factor,proteins
R5811	T22490	T22486	nsubj	genes,affect
R5812	T22188	T22189	nmod	orphan,receptor
R5813	T22491	T22490	amod	mammalian,genes
R5814	T22492	T22493	compound	DM,domain
R5815	T22189	T22187	nmod	receptor,factor
R5816	T22493	T22490	compound	domain,genes
R5817	T22494	T22495	amod	gonadal,development
R5818	T22495	T22486	dobj	development,affect
R5819	T22496	T22497	advmod	only,in
R5820	T22190	T22191	nmod	germ,cell
R5821	T22497	T22486	prep	in,affect
R5822	T22498	T22499	nummod	one,sex
R5823	T22191	T22187	nmod	cell,factor
R5824	T22499	T22497	pobj	sex,in
R5825	T22500	T22486	punct	", ",affect
R5826	T22501	T22486	prep	given,affect
R5827	T22192	T22191	punct	-,cell
R5828	T22502	T22503	det	the,roles
R5829	T22503	T22501	pobj	roles,given
R5830	T22193	T22187	amod	nuclear,factor
R5831	T22504	T22503	amod	similar,roles
R5832	T22505	T22503	prep	of,roles
R5833	T22194	T22187	punct	", ",factor
R5834	T22506	T22507	amod	related,proteins
R5835	T22507	T22505	pobj	proteins,of
R5836	T22195	T22187	cc	and,factor
R5837	T22508	T22503	prep	in,roles
R5838	T22196	T22197	npadvmod	recombination,related
R5839	T22509	T22508	pcomp	directing,in
R5840	T22510	T22511	npadvmod	sex,specific
R5841	T22511	T22513	amod	specific,development
R5842	T22512	T22511	punct	-,specific
R5843	T22513	T22509	dobj	development,directing
R5844	T22197	T22199	amod	related,proteins
R5845	T22514	T22513	amod	somatic,development
R5846	T22515	T22509	prep	in,directing
R5847	T22516	T22517	amod	other,phyla
R5848	T22198	T22197	punct	-,related
R5849	T22517	T22515	pobj	phyla,in
R5850	T22518	T22483	punct	.,is
R5851	T22199	T22187	conj	proteins,factor
R5852	T22520	T22521	advmod	Strikingly,is
R5853	T22200	T22201	punct	[,60
R5854	T22522	T22521	punct	", ",is
R5855	T22201	T22155	parataxis	60,identified
R5856	T22523	T22521	nsubj	Dmrt7,is
R5857	T22524	T22521	acomp	present,is
R5858	T22525	T22521	punct	", ",is
R5859	T22202	T22201	punct	],60
R5860	T22526	T22527	preconj	not,in
R5861	T22527	T22521	prep	in,is
R5862	T22203	T22155	punct	.,identified
R5863	T22528	T22526	advmod	only,not
R5864	T22529	T22530	amod	placental,mammals
R5865	T22205	T22206	det	A,feature
R5866	T22530	T22527	pobj	mammals,in
R5867	T22531	T22527	punct	", ",in
R5868	T22532	T22527	cc	but,in
R5869	T22206	T22208	nsubj	feature,is
R5870	T22533	T22532	advmod	also,but
R5871	T22534	T22527	conj	in,in
R5872	T22535	T22534	pobj	marsupials,in
R5873	T22536	T22535	cc	and,marsupials
R5874	T22537	T22538	det	a,monotreme
R5875	T22207	T22206	amod	common,feature
R5876	T22538	T22535	conj	monotreme,marsupials
R5877	T22539	T22540	punct	(,mammal
R5878	T22209	T22206	prep	of,feature
R5879	T22540	T22538	parataxis	mammal,monotreme
R5880	T22210	T22211	det	these,proteins
R5881	T22541	T22540	nmod	egg,mammal
R5882	T22542	T22541	punct	-,egg
R5883	T22211	T22209	pobj	proteins,of
R5884	T22543	T22541	amod	laying,egg
R5885	T22544	T22540	punct	),mammal
R5886	T22212	T22208	attr	involvement,is
R5887	T22545	T22538	punct	", ",monotreme
R5888	T22213	T22212	prep	with,involvement
R5889	T22546	T22547	det	the,platypus
R5890	T22547	T22538	appos	platypus,monotreme
R5891	T22214	T22215	nmod	heterochromatin,repression
R5892	T22215	T22213	pobj	repression,with
R5893	T22548	T22547	punct	", ",platypus
R5894	T22216	T22214	cc	and,heterochromatin
R5895	T22549	T22550	dep	which,has
R5896	T22217	T22216	punct	/,and
R5897	T22550	T22547	relcl	has,platypus
R5898	T22218	T22216	cc	or,and
R5899	T22551	T22552	det	a,ortholog
R5900	T22552	T22550	dobj	ortholog,has
R5901	T22219	T22214	conj	transcriptional,heterochromatin
R5902	T22553	T22552	amod	clear,ortholog
R5903	T22554	T22552	compound	Dmrt7,ortholog
R5904	T22220	T22208	punct	.,is
R5905	T22555	T22556	punct	[,36
R5906	T22222	T22223	nsubj	DMRT7,is
R5907	T22556	T22521	parataxis	36,is
R5908	T22557	T22556	punct	],36
R5909	T22558	T22521	punct	.,is
R5910	T22224	T22223	acomp	unusual,is
R5911	T22560	T22561	advmod	However,reported
R5912	T22225	T22223	prep	among,is
R5913	T22562	T22561	punct	", ",reported
R5914	T22226	T22227	compound	XY,proteins
R5915	T22563	T22564	det	no,ortholog
R5916	T22564	T22561	nsubjpass	ortholog,reported
R5917	T22227	T22225	pobj	proteins,among
R5918	T22565	T22564	amod	close,ortholog
R5919	T22566	T22564	compound	Dmrt7,ortholog
R5920	T22567	T22561	aux	has,reported
R5921	T22228	T22227	compound	body,proteins
R5922	T22568	T22561	auxpass	been,reported
R5923	T22569	T22561	prep	in,reported
R5924	T22570	T22571	amod	nonmammalian,vertebrates
R5925	T22229	T22223	prep	in,is
R5926	T22571	T22569	pobj	vertebrates,in
R5927	T22572	T22561	punct	", ",reported
R5928	T22573	T22561	cc	and,reported
R5929	T22230	T22229	pcomp	being,in
R5930	T22574	T22575	poss	our,searches
R5931	T22575	T22577	nsubj	searches,reveal
R5932	T22231	T22230	acomp	related,being
R5933	T22576	T22575	compound	database,searches
R5934	T22577	T22561	conj	reveal,reported
R5935	T22232	T22231	prep	to,related
R5936	T22578	T22577	aux	did,reveal
R5937	T22579	T22577	neg	not,reveal
R5938	T22233	T22234	advmod	highly,specific
R5939	T22580	T22577	dobj	one,reveal
R5940	T22234	T22237	amod	specific,regulators
R5941	T22581	T22577	punct	.,reveal
R5942	T22583	T22584	advmod	Thus,arose
R5943	T22235	T22234	npadvmod	site,specific
R5944	T22585	T22584	punct	", ",arose
R5945	T22236	T22234	punct	-,specific
R5946	T22586	T22584	nsubj	Dmrt7,arose
R5947	T22237	T22232	pobj	regulators,to
R5948	T22587	T22584	advmod	likely,arose
R5949	T22588	T22584	punct	", ",arose
R5950	T22238	T22237	amod	transcriptional,regulators
R5951	T22589	T22590	advmod	presumably,by
R5952	T22590	T22584	prep	by,arose
R5953	T22239	T22223	punct	.,is
R5954	T22591	T22590	pobj	duplication,by
R5955	T22592	T22591	cc	and,duplication
R5956	T22241	T22242	det	An,speculation
R5957	T22593	T22591	conj	divergence,duplication
R5958	T22594	T22591	prep	of,duplication
R5959	T22242	T22244	nsubj	speculation,is
R5960	T22595	T22596	det	another,gene
R5961	T22596	T22594	pobj	gene,of
R5962	T22243	T22242	amod	attractive,speculation
R5963	T22597	T22596	compound	Dmrt,gene
R5964	T22598	T22584	punct	", ",arose
R5965	T22245	T22246	mark	that,provide
R5966	T22599	T22600	advmod	shortly,before
R5967	T22600	T22584	prep	before,arose
R5968	T22601	T22600	cc	or,before
R5969	T22246	T22244	ccomp	provide,is
R5970	T22602	T22603	ccomp	coincident,radiation
R5971	T22603	T22600	conj	radiation,before
R5972	T22247	T22246	nsubj	DMRT7,provide
R5973	T22248	T22246	aux	may,provide
R5974	T22249	T22250	compound	sequence,specificity
R5975	T22604	T22602	prep	with,coincident
R5976	T22605	T22603	det	the,radiation
R5977	T22606	T22603	amod	mammalian,radiation
R5978	T22607	T22584	punct	.,arose
R5979	T22250	T22246	dobj	specificity,provide
R5980	T22609	T22610	nsubj	Monotremes,have
R5981	T22251	T22246	prep	in,provide
R5982	T22611	T22612	nummod	five,X
R5983	T22612	T22610	dobj	X,have
R5984	T22613	T22612	cc	and,X
R5985	T22252	T22251	pcomp	recruiting,in
R5986	T22614	T22615	nummod	five,Y
R5987	T22615	T22616	compound	Y,chromosomes
R5988	T22616	T22612	conj	chromosomes,X
R5989	T22253	T22254	amod	other,proteins
R5990	T22617	T22612	punct	", ",X
R5991	T22618	T22619	dep	which,form
R5992	T22254	T22252	dobj	proteins,recruiting
R5993	T22619	T22612	relcl	form,X
R5994	T22620	T22621	det	an,chain
R5995	T22255	T22254	punct	", ",proteins
R5996	T22621	T22619	dobj	chain,form
R5997	T22622	T22621	amod	extended,chain
R5998	T22256	T22257	amod	such,as
R5999	T22623	T22621	compound	pairing,chain
R6000	T22624	T22619	prep	during,form
R6001	T22625	T22624	pobj	meiosis,during
R6002	T22257	T22254	prep	as,proteins
R6003	T22626	T22619	cc	and,form
R6004	T22627	T22619	conj	appear,form
R6005	T22258	T22259	compound	chromatin,modifiers
R6006	T22259	T22257	pobj	modifiers,as
R6007	T22628	T22627	oprd	unrelated,appear
R6008	T22260	T22252	punct	", ",recruiting
R6009	T22629	T22628	prep	to,unrelated
R6010	T22630	T22631	det	the,chromosomes
R6011	T22261	T22252	prep	to,recruiting
R6012	T22631	T22629	pobj	chromosomes,to
R6013	T22632	T22631	compound	sex,chromosomes
R6014	T22262	T22263	det	the,body
R6015	T22633	T22631	prep	of,chromosomes
R6016	T22634	T22635	det	the,mammals
R6017	T22263	T22261	pobj	body,to
R6018	T22635	T22633	pobj	mammals,of
R6019	T22636	T22635	amod	other,mammals
R6020	T22264	T22263	compound	XY,body
R6021	T22637	T22638	punct	[,61
R6022	T22638	T22612	parataxis	61,X
R6023	T22265	T22252	prep	as,recruiting
R6024	T22639	T22638	punct	],61
R6025	T22640	T22610	punct	.,have
R6026	T22266	T22265	pobj	part,as
R6027	T22642	T22643	det	The,presence
R6028	T22643	T22644	nsubj	presence,support
R6029	T22267	T22266	prep	of,part
R6030	T22645	T22643	prep	of,presence
R6031	T22646	T22645	pobj	Dmrt7,of
R6032	T22647	T22643	prep	in,presence
R6033	T22268	T22269	det	the,transition
R6034	T22648	T22649	det	both,lineages
R6035	T22649	T22647	pobj	lineages,in
R6036	T22650	T22644	aux	may,support
R6037	T22269	T22267	pobj	transition,of
R6038	T22270	T22269	prep	to,transition
R6039	T22651	T22652	det	a,origin
R6040	T22652	T22644	dobj	origin,support
R6041	T22271	T22270	pobj	PMSC,to
R6042	T22653	T22652	amod	common,origin
R6043	T22654	T22652	prep	for,origin
R6044	T22272	T22244	punct	.,is
R6045	T22655	T22656	preconj	either,chromosomes
R6046	T22656	T22654	pobj	chromosomes,for
R6047	T22274	T22275	compound	Chromatin,regulation
R6048	T22657	T22656	det	the,chromosomes
R6049	T22658	T22656	compound	sex,chromosomes
R6050	T22659	T22656	cc	or,chromosomes
R6051	T22275	T22276	nsubj	regulation,be
R6052	T22660	T22661	det	the,chromatin
R6053	T22661	T22656	conj	chromatin,chromosomes
R6054	T22277	T22276	aux	may,be
R6055	T22662	T22661	compound	sex,chromatin
R6056	T22663	T22656	prep	of,chromosomes
R6057	T22664	T22663	pobj	monotremes,of
R6058	T22278	T22279	det	a,mechanism
R6059	T22665	T22664	cc	and,monotremes
R6060	T22666	T22667	amod	other,mammals
R6061	T22279	T22276	attr	mechanism,be
R6062	T22667	T22664	conj	mammals,monotremes
R6063	T22668	T22644	punct	.,support
R6064	T22280	T22279	amod	common,mechanism
R6065	T22670	T22671	det	A,model
R6066	T22671	T22673	nsubj	model,is
R6067	T22281	T22279	prep	for,mechanism
R6068	T22672	T22671	amod	plausible,model
R6069	T22282	T22283	compound	DM,proteins
R6070	T22674	T22675	mark	that,evolved
R6071	T22675	T22673	ccomp	evolved,is
R6072	T22676	T22675	nsubj	Dmrt7,evolved
R6073	T22283	T22281	pobj	proteins,for
R6074	T22677	T22675	prep	during,evolved
R6075	T22678	T22679	det	the,establishment
R6076	T22679	T22677	pobj	establishment,during
R6077	T22680	T22679	prep	of,establishment
R6078	T22681	T22682	amod	mammalian,determination
R6079	T22284	T22283	compound	domain,proteins
R6080	T22682	T22680	pobj	determination,of
R6081	T22683	T22682	compound	sex,determination
R6082	T22285	T22276	punct	", ",be
R6083	T22684	T22685	aux	to,cope
R6084	T22685	T22675	advcl	cope,evolved
R6085	T22686	T22685	aux	help,cope
R6086	T22687	T22685	prep	with,cope
R6087	T22688	T22689	amod	ancestral,differences
R6088	T22689	T22687	pobj	differences,with
R6089	T22286	T22287	mark	as,find
R6090	T22690	T22689	prep	in,differences
R6091	T22691	T22692	compound	gene,dosage
R6092	T22692	T22690	pobj	dosage,in
R6093	T22287	T22276	advcl	find,be
R6094	T22693	T22692	punct	", ",dosage
R6095	T22694	T22695	compound	chromosome,pairing
R6096	T22695	T22692	conj	pairing,dosage
R6097	T22288	T22287	nsubj	we,find
R6098	T22696	T22695	punct	", ",pairing
R6099	T22697	T22695	conj	recombination,pairing
R6100	T22698	T22697	punct	", ",recombination
R6101	T22289	T22290	mark	that,associate
R6102	T22699	T22697	cc	or,recombination
R6103	T22700	T22701	amod	other,issues
R6104	T22701	T22697	conj	issues,recombination
R6105	T22290	T22287	ccomp	associate,find
R6106	T22702	T22701	amod	meiotic,issues
R6107	T22703	T22701	acl	arising,issues
R6108	T22704	T22703	prep	from,arising
R6109	T22291	T22292	amod	other,proteins
R6110	T22705	T22706	compound	sex,chromosome
R6111	T22292	T22290	nsubj	proteins,associate
R6112	T22293	T22294	compound	DM,domain
R6113	T22706	T22707	compound	chromosome,heteromorphy
R6114	T22294	T22292	compound	domain,proteins
R6115	T22707	T22704	pobj	heteromorphy,from
R6116	T22295	T22290	prep	with,associate
R6117	T22708	T22673	punct	.,is
R6118	T22296	T22297	compound	chromatin,modifying
R6119	T22710	T22711	prep	In,speculate
R6120	T22712	T22713	det	this,regard
R6121	T22297	T22298	compound	modifying,complexes
R6122	T22713	T22710	pobj	regard,In
R6123	T22298	T22295	pobj	complexes,with
R6124	T22714	T22711	punct	", ",speculate
R6125	T22299	T22300	punct	(,M.
R6126	T22715	T22711	nsubj	we,speculate
R6127	T22716	T22717	mark	that,be
R6128	T22300	T22276	meta	M.,be
R6129	T22717	T22711	ccomp	be,speculate
R6130	T22301	T22300	nmod	W.,M.
R6131	T22718	T22719	det	the,recruitment
R6132	T22302	T22300	nmod	Murphy,M.
R6133	T22719	T22717	nsubj	recruitment,be
R6134	T22720	T22719	prep	of,recruitment
R6135	T22721	T22720	pobj	Dmrt7,of
R6136	T22722	T22719	prep	during,recruitment
R6137	T22723	T22724	amod	mammalian,evolution
R6138	T22303	T22300	punct	", ",M.
R6139	T22724	T22722	pobj	evolution,during
R6140	T22725	T22717	aux	may,be
R6141	T22304	T22300	conj	D.,M.
R6142	T22726	T22717	acomp	analogous,be
R6143	T22727	T22726	prep	to,analogous
R6144	T22728	T22729	det	the,recruitment
R6145	T22305	T22304	nmod	Zarkower,D.
R6146	T22729	T22727	pobj	recruitment,to
R6147	T22730	T22729	prep	of,recruitment
R6148	T22306	T22304	punct	", ",D.
R6149	T22731	T22732	nmod	chromatin,complexes
R6150	T22732	T22730	pobj	complexes,of
R6151	T22733	T22732	amod	regulatory,complexes
R6152	T22307	T22304	cc	and,D.
R6153	T22734	T22735	aux	to,achieve
R6154	T22735	T22729	advcl	achieve,recruitment
R6155	T22308	T22304	conj	V.,D.
R6156	T22736	T22737	amod	somatic,compensation
R6157	T22737	T22735	dobj	compensation,achieve
R6158	T22738	T22737	compound	dosage,compensation
R6159	T22309	T22308	nmod	J.,V.
R6160	T22739	T22735	prep	during,achieve
R6161	T22740	T22739	pobj	evolution,during
R6162	T22310	T22308	nmod	Bardwell,V.
R6163	T22741	T22740	prep	of,evolution
R6164	T22742	T22743	amod	heteromorphic,chromosomes
R6165	T22311	T22308	punct	", ",V.
R6166	T22743	T22741	pobj	chromosomes,of
R6167	T22744	T22743	compound	sex,chromosomes
R6168	T22312	T22313	amod	unpublished,data
R6169	T22745	T22740	prep	in,evolution
R6170	T22746	T22747	amod	several,phyla
R6171	T22747	T22745	pobj	phyla,in
R6172	T22313	T22308	conj	data,V.
R6173	T22748	T22749	punct	(,reviewed
R6174	T22749	T22711	parataxis	reviewed,speculate
R6175	T22750	T22749	prep	in,reviewed
R6176	T22314	T22313	punct	),data
R6177	T22751	T22752	punct	[,62
R6178	T22752	T22750	pobj	62,in
R6179	T22753	T22749	punct	],reviewed
R6180	T22754	T22749	punct	),reviewed
R6181	T22755	T22711	punct	.,speculate
R6182	T22315	T22276	punct	.,be
R6183	T22317	T22318	det	The,finding
R6184	T22757	T22758	nsubj	It,be
R6185	T22318	T22319	nsubj	finding,expands
R6186	T22759	T22758	aux	will,be
R6187	T22320	T22321	mark	that,is
R6188	T22321	T22318	acl	is,finding
R6189	T22760	T22758	prep	of,be
R6190	T22322	T22321	nsubj	Dmrt7,is
R6191	T22761	T22760	pobj	interest,of
R6192	T22762	T22763	aux	to,determine
R6193	T22763	T22758	xcomp	determine,be
R6194	T22764	T22765	mark	whether,localizes
R6195	T22323	T22321	acomp	essential,is
R6196	T22765	T22763	ccomp	localizes,determine
R6197	T22766	T22765	nsubj	DMRT7,localizes
R6198	T22324	T22323	prep	for,essential
R6199	T22767	T22765	prep	to,localizes
R6200	T22768	T22769	compound	sex,chromosomes
R6201	T22325	T22326	amod	mammalian,meiosis
R6202	T22769	T22767	pobj	chromosomes,to
R6203	T22770	T22765	prep	during,localizes
R6204	T22326	T22324	pobj	meiosis,for
R6205	T22771	T22772	compound	monotreme,meiosis
R6206	T22772	T22770	pobj	meiosis,during
R6207	T22327	T22328	det	the,functions
R6208	T22773	T22758	punct	.,be
R6209	T22328	T22319	dobj	functions,expands
R6210	T22775	T22776	prep	In,found
R6211	T22329	T22328	amod	known,functions
R6212	T22777	T22775	pobj	summary,In
R6213	T22778	T22776	punct	", ",found
R6214	T22779	T22776	nsubj	we,found
R6215	T22330	T22328	prep	of,functions
R6216	T22780	T22776	aux	have,found
R6217	T22781	T22782	mark	that,is
R6218	T22782	T22776	ccomp	is,found
R6219	T22331	T22332	det	this,family
R6220	T22783	T22784	det	the,DMRT7
R6221	T22784	T22782	nsubj	DMRT7,is
R6222	T22332	T22330	pobj	family,of
R6223	T22785	T22786	npadvmod	mammal,specific
R6224	T22786	T22784	amod	specific,DMRT7
R6225	T22787	T22786	punct	-,specific
R6226	T22333	T22332	compound	gene,family
R6227	T22788	T22789	compound	DM,domain
R6228	T22789	T22784	compound	domain,DMRT7
R6229	T22790	T22784	compound	protein,DMRT7
R6230	T22334	T22319	punct	.,expands
R6231	T22791	T22782	acomp	essential,is
R6232	T22792	T22791	prep	for,essential
R6233	T22336	T22337	compound	Invertebrate,genes
R6234	T22793	T22794	amod	meiotic,prophase
R6235	T22794	T22795	compound	prophase,progression
R6236	T22795	T22792	pobj	progression,for
R6237	T22337	T22340	nsubjpass	genes,found
R6238	T22796	T22795	prep	in,progression
R6239	T22797	T22796	pobj	males,in
R6240	T22338	T22339	compound	DM,domain
R6241	T22339	T22337	compound	domain,genes
R6242	T22798	T22776	punct	.,found
R6243	T22800	T22801	nsubj	DMRT7,localizes
R6244	T22341	T22342	advmod	so,far
R6245	T22802	T22801	prep	to,localizes
R6246	T22803	T22804	det	the,chromosomes
R6247	T22342	T22340	advmod	far,found
R6248	T22804	T22802	pobj	chromosomes,to
R6249	T22805	T22804	compound	sex,chromosomes
R6250	T22806	T22807	mark	after,assembled
R6251	T22343	T22340	aux	have,found
R6252	T22807	T22801	advcl	assembled,localizes
R6253	T22808	T22807	nsubjpass	they,assembled
R6254	T22344	T22340	advmod	only,found
R6255	T22809	T22807	auxpass	are,assembled
R6256	T22810	T22807	prep	into,assembled
R6257	T22345	T22340	auxpass	been,found
R6258	T22811	T22812	amod	specialized,heterochromatin
R6259	T22812	T22810	pobj	heterochromatin,into
R6260	T22813	T22801	punct	", ",localizes
R6261	T22346	T22347	aux	to,function
R6262	T22814	T22801	cc	and,localizes
R6263	T22815	T22816	amod	many,cells
R6264	T22347	T22340	xcomp	function,found
R6265	T22816	T22819	nsubj	cells,have
R6266	T22817	T22816	compound	Dmrt7,cells
R6267	T22348	T22347	prep	in,function
R6268	T22818	T22816	compound	mutant,cells
R6269	T22819	T22801	conj	have,localizes
R6270	T22349	T22350	amod	somatic,cells
R6271	T22820	T22821	amod	epigenetic,defects
R6272	T22821	T22819	dobj	defects,have
R6273	T22822	T22821	prep	in,defects
R6274	T22350	T22348	pobj	cells,in
R6275	T22823	T22824	det	the,modification
R6276	T22824	T22822	pobj	modification,in
R6277	T22351	T22340	punct	.,found
R6278	T22825	T22824	prep	of,modification
R6279	T22826	T22827	det	the,chromatin
R6280	T22827	T22825	pobj	chromatin,of
R6281	T22353	T22354	nummod	Two,genes
R6282	T22828	T22827	compound	sex,chromatin
R6283	T22829	T22824	prep	between,modification
R6284	T22830	T22829	pobj	pachytene,between
R6285	T22354	T22358	nsubj	genes,affect
R6286	T22831	T22830	cc	and,pachytene
R6287	T22832	T22830	conj	diplotene,pachytene
R6288	T22833	T22819	punct	.,have
R6289	T22355	T22354	amod	other,genes
R6290	T22356	T22357	compound	DM,domain
R6291	T22357	T22354	compound	domain,genes
R6292	T22835	T22836	mark	Although,belongs
R6293	T22359	T22354	punct	", ",genes
R6294	T22360	T22354	appos	Dmrt1,genes
R6295	T22836	T22838	advcl	belongs,found
R6296	T22837	T22836	nsubj	Dmrt7,belongs
R6297	T22361	T22360	cc	and,Dmrt1
R6298	T22839	T22836	prep	to,belongs
R6299	T22362	T22360	conj	Dmrt4,Dmrt1
R6300	T22840	T22841	det	an,family
R6301	T22363	T22358	punct	", ",affect
R6302	T22841	T22839	pobj	family,to
R6303	T22842	T22841	amod	ancient,family
R6304	T22364	T22358	aux	do,affect
R6305	T22843	T22842	cc	and,ancient
R6306	T22844	T22842	conj	conserved,ancient
R6307	T22365	T22366	compound	germ,cell
R6308	T22845	T22841	compound	gene,family
R6309	T22846	T22838	punct	", ",found
R6310	T22366	T22367	compound	cell,development
R6311	T22847	T22838	nsubjpass	it,found
R6312	T22848	T22838	auxpass	is,found
R6313	T22367	T22358	dobj	development,affect
R6314	T22849	T22850	advmod	only,in
R6315	T22368	T22358	prep	in,affect
R6316	T22850	T22838	prep	in,found
R6317	T22851	T22850	pobj	mammals,in
R6318	T22369	T22370	det	the,mouse
R6319	T22852	T22838	punct	", ",found
R6320	T22853	T22838	cc	and,found
R6321	T22370	T22368	pobj	mouse,in
R6322	T22854	T22855	prep	to,is
R6323	T22855	T22838	conj	is,found
R6324	T22856	T22857	poss	our,knowledge
R6325	T22371	T22358	punct	.,affect
R6326	T22857	T22854	pobj	knowledge,to
R6327	T22858	T22855	nsubj	DMRT7,is
R6328	T22373	T22374	nsubjpass	Dmrt1,required
R6329	T22859	T22860	det	the,example
R6330	T22860	T22855	attr	example,is
R6331	T22375	T22374	auxpass	is,required
R6332	T22861	T22860	amod	only,example
R6333	T22862	T22860	prep	of,example
R6334	T22376	T22374	prep	in,required
R6335	T22377	T22378	amod	pre-meiotic,cells
R6336	T22863	T22864	det	a,protein
R6337	T22378	T22376	pobj	cells,in
R6338	T22864	T22862	pobj	protein,of
R6339	T22865	T22866	npadvmod	mammal,specific
R6340	T22379	T22378	amod	male,cells
R6341	T22866	T22864	amod	specific,protein
R6342	T22867	T22866	punct	-,specific
R6343	T22380	T22378	compound	germ,cells
R6344	T22868	T22869	dep	that,is
R6345	T22381	T22374	prep	for,required
R6346	T22869	T22864	relcl	is,protein
R6347	T22870	T22869	acomp	essential,is
R6348	T22871	T22870	prep	for,essential
R6349	T22872	T22871	pobj	meiosis,for
R6350	T22873	T22855	punct	.,is
R6351	T22382	T22381	pobj	differentiation,for
R6352	T22875	T22876	nsubj	It,be
R6353	T22383	T22382	prep	of,differentiation
R6354	T22877	T22876	aux	will,be
R6355	T22384	T22383	pobj	gonocytes,of
R6356	T22878	T22876	acomp	important,be
R6357	T22879	T22880	aux	to,determine
R6358	T22385	T22382	prep	into,differentiation
R6359	T22880	T22876	xcomp	determine,be
R6360	T22881	T22882	det	the,mechanism
R6361	T22386	T22385	pobj	spermatogonia,into
R6362	T22882	T22880	dobj	mechanism,determine
R6363	T22387	T22374	punct	", ",required
R6364	T22883	T22882	amod	precise,mechanism
R6365	T22884	T22885	prep	by,affects
R6366	T22388	T22389	advmod	as,as
R6367	T22389	T22391	cc	as,in
R6368	T22390	T22389	advmod	well,as
R6369	T22885	T22882	relcl	affects,mechanism
R6370	T22886	T22884	pobj	which,by
R6371	T22391	T22374	prep	in,required
R6372	T22887	T22885	nsubj	DMRT7,affects
R6373	T22888	T22889	compound	sex,regulation
R6374	T22392	T22393	compound	Sertoli,cells
R6375	T22889	T22885	dobj	regulation,affects
R6376	T22393	T22391	pobj	cells,in
R6377	T22890	T22889	compound	chromatin,regulation
R6378	T22891	T22885	prep	during,affects
R6379	T22892	T22893	amod	male,meiosis
R6380	T22893	T22891	pobj	meiosis,during
R6381	T22894	T22876	punct	.,be
R286	T1123	T1121	pobj	vertebrates,in
R287	T1124	T1106	punct	", ",shed
R288	T1125	T1106	nsubj	Dmrt7,shed
R3562	T13275	T13258	cc	and,packed
R2653	T10014	T10015	punct	[,42
R1624	T6933	T6934	det	the,wave
R4545	T17588	T17586	pobj	body,through

2_test

Id	Subject	Object	Predicate	Lexical cue
17447844-16322537-85805794	3807-3808	16322537	denotes	1
17447844-9352191-85805795	4156-4157	9352191	denotes	2
17447844-11283700-85805796	4701-4702	11283700	denotes	3
17447844-16322537-85805797	5006-5007	16322537	denotes	1
17447844-16543383-85805798	5008-5009	16543383	denotes	4
17447844-16847345-85805799	5296-5297	16847345	denotes	5
17447844-15818384-85805800	5298-5299	15818384	denotes	6
17447844-8432196-85805801	5805-5806	8432196	denotes	7
17447844-11242108-85805801	5805-5806	11242108	denotes	7
17447844-3226141-85805801	5805-5806	3226141	denotes	7
17447844-9500548-85805801	5805-5806	9500548	denotes	7
17447844-15051945-85805801	5805-5806	15051945	denotes	7
17447844-12689589-85805802	5885-5887	12689589	denotes	12
17447844-12689589-85805803	6086-6088	12689589	denotes	12
17447844-10068466-85805803	6086-6088	10068466	denotes	12
17447844-15589157-85805803	6086-6088	15589157	denotes	12
17447844-17237782-85805803	6086-6088	17237782	denotes	12
17447844-16581510-85805804	6349-6351	16581510	denotes	16
17447844-16581510-85805805	6513-6515	16581510	denotes	16
17447844-16580996-85805806	6516-6518	16580996	denotes	17
17447844-9490411-85805807	6964-6966	9490411	denotes	18
17447844-8440242-85805808	6967-6969	8440242	denotes	19
17447844-11256069-85805809	7103-7105	11256069	denotes	20
17447844-9490411-85805810	7409-7411	9490411	denotes	18
17447844-3046751-85805811	7412-7414	3046751	denotes	21
17447844-6771185-85805812	7415-7417	6771185	denotes	22
17447844-12609607-85805813	7673-7675	12609607	denotes	23
17447844-15008421-85805814	7676-7678	15008421	denotes	24
17447844-12193652-85805815	7940-7942	12193652	denotes	25
17447844-10604464-85805815	7940-7942	10604464	denotes	25
17447844-10705377-85805815	7940-7942	10705377	denotes	25
17447844-10545231-85805815	7940-7942	10545231	denotes	25
17447844-12037570-85805815	7940-7942	12037570	denotes	25
17447844-10332030-85805816	8096-8098	10332030	denotes	30
17447844-11040213-85805817	8248-8250	11040213	denotes	31
17447844-16982677-85805818	8376-8378	16982677	denotes	32
17447844-16136187-85805819	8651-8653	16136187	denotes	33
17447844-16387292-85805819	8651-8653	16387292	denotes	33
17447844-10021344-85805819	8651-8653	10021344	denotes	33
17447844-12609607-85805820	8900-8902	12609607	denotes	23
17447844-16488114-85805821	8903-8905	16488114	denotes	36
17447844-12609607-85805822	9733-9735	12609607	denotes	23
17447844-16543383-85805823	9907-9908	16543383	denotes	4
17447844-874003-85805824	10530-10532	874003	denotes	37
17447844-7924983-85805825	12165-12167	7924983	denotes	38
17447844-16580996-85805826	12648-12650	16580996	denotes	17
17447844-15349788-85805827	12858-12860	15349788	denotes	39
17447844-15950612-85805828	12861-12863	15950612	denotes	40
17447844-9490411-85805829	14134-14136	9490411	denotes	18
17447844-8440242-85805830	14137-14139	8440242	denotes	19
17447844-12231628-85805831	14140-14142	12231628	denotes	41
17447844-17098235-85805832	16996-16998	17098235	denotes	42
17447844-9568529-85805833	19588-19590	9568529	denotes	43
17447844-8286583-85805834	19919-19921	8286583	denotes	44
17447844-1449797-85805835	20242-20244	1449797	denotes	45
17447844-15338235-85805836	21674-21676	15338235	denotes	64
17447844-10973068-85805837	21836-21838	10973068	denotes	46
17447844-3552678-85805838	22110-22112	3552678	denotes	47
17447844-8289794-85805839	22113-22115	8289794	denotes	48
17447844-9443891-85805840	22689-22691	9443891	denotes	49
17447844-15466940-85805841	23834-23836	15466940	denotes	50
17447844-12954777-85805842	26206-26208	12954777	denotes	51
17447844-8805249-85805843	26421-26423	8805249	denotes	52
17447844-4854664-85805844	27818-27820	4854664	denotes	53
17447844-12689589-85805845	28089-28091	12689589	denotes	12
17447844-15950612-85805846	28607-28609	15950612	denotes	40
17447844-10068466-85805847	29342-29344	10068466	denotes	13
17447844-16580996-85805848	30456-30458	16580996	denotes	17
17447844-16581510-85805849	30678-30680	16581510	denotes	16
17447844-9499427-85805850	31486-31488	9499427	denotes	54
17447844-15051956-85805851	31489-31491	15051956	denotes	55
17447844-11591824-85805852	31829-31831	11591824	denotes	56
17447844-16581510-85805853	32402-32404	16581510	denotes	16
17447844-16581510-85805854	34179-34181	16581510	denotes	16
17447844-16809775-85805855	34182-34184	16809775	denotes	57
17447844-15536132-85805856	34185-34187	15536132	denotes	58
17447844-9488723-85805857	35292-35294	9488723	denotes	59
17447844-10973068-85805858	37461-37463	10973068	denotes	46
17447844-16580996-85805859	37799-37801	16580996	denotes	17
17447844-15120994-85805860	40376-40378	15120994	denotes	60
17447844-11040213-85805861	41459-41461	11040213	denotes	31
17447844-16488114-85805862	42248-42250	16488114	denotes	36
17447844-15502814-85805863	42692-42694	15502814	denotes	61
17447844-11084626-85805864	43378-43380	11084626	denotes	62
17447844-11040213-85805865	44631-44633	11040213	denotes	31
17447844-12609607-85805866	46720-46722	12609607	denotes	23
17447844-14769957-85805867	50428-50430	14769957	denotes	63
17447844-16581510-85805868	50528-50530	16581510	denotes	16
17447844-16581510-85805869	50678-50680	16581510	denotes	16
17447844-14769957-85805870	50681-50683	14769957	denotes	63
T60625	3807-3808	16322537	denotes	1
T17613	4156-4157	9352191	denotes	2
T37895	4701-4702	11283700	denotes	3
T57549	5006-5007	16322537	denotes	1
T44875	5008-5009	16543383	denotes	4
T50692	5296-5297	16847345	denotes	5
T24257	5298-5299	15818384	denotes	6
T34775	5805-5806	8432196	denotes	7
T93921	5805-5806	11242108	denotes	7
T22980	5805-5806	3226141	denotes	7
T23223	5805-5806	9500548	denotes	7
T69726	5805-5806	15051945	denotes	7
T76085	5885-5887	12689589	denotes	12
T47649	6086-6088	12689589	denotes	12
T99788	6086-6088	10068466	denotes	12
T23202	6086-6088	15589157	denotes	12
T85107	6086-6088	17237782	denotes	12
T95544	6349-6351	16581510	denotes	16
T98525	6513-6515	16581510	denotes	16
T32156	6516-6518	16580996	denotes	17
T26979	6964-6966	9490411	denotes	18
T53526	6967-6969	8440242	denotes	19
T34514	7103-7105	11256069	denotes	20
T62140	7409-7411	9490411	denotes	18
T75318	7412-7414	3046751	denotes	21
T16325	7415-7417	6771185	denotes	22
T43652	7673-7675	12609607	denotes	23
T24429	7676-7678	15008421	denotes	24
T24093	7940-7942	12193652	denotes	25
T35232	7940-7942	10604464	denotes	25
T35576	7940-7942	10705377	denotes	25
T17704	7940-7942	10545231	denotes	25
T24158	7940-7942	12037570	denotes	25
T44051	8096-8098	10332030	denotes	30
T58294	8248-8250	11040213	denotes	31
T5988	8376-8378	16982677	denotes	32
T23745	8651-8653	16136187	denotes	33
T98040	8651-8653	16387292	denotes	33
T10581	8651-8653	10021344	denotes	33
T7909	8900-8902	12609607	denotes	23
T28012	8903-8905	16488114	denotes	36
T36382	9733-9735	12609607	denotes	23
T2311	9907-9908	16543383	denotes	4
T48008	10530-10532	874003	denotes	37
T53731	12165-12167	7924983	denotes	38
T51799	12648-12650	16580996	denotes	17
T61323	12858-12860	15349788	denotes	39
T56632	12861-12863	15950612	denotes	40
T76478	14134-14136	9490411	denotes	18
T79576	14137-14139	8440242	denotes	19
T77707	14140-14142	12231628	denotes	41
T53612	16996-16998	17098235	denotes	42
T69424	19588-19590	9568529	denotes	43
T64408	19919-19921	8286583	denotes	44
T17112	20242-20244	1449797	denotes	45
T35872	21674-21676	15338235	denotes	64
T43439	21836-21838	10973068	denotes	46
T45648	22110-22112	3552678	denotes	47
T6109	22113-22115	8289794	denotes	48
T33109	22689-22691	9443891	denotes	49
T43682	23834-23836	15466940	denotes	50
T32303	26206-26208	12954777	denotes	51
T40950	26421-26423	8805249	denotes	52
T56695	27818-27820	4854664	denotes	53
T90272	28089-28091	12689589	denotes	12
T5950	28607-28609	15950612	denotes	40
T47209	29342-29344	10068466	denotes	13
T2977	30456-30458	16580996	denotes	17
T9467	30678-30680	16581510	denotes	16
T72574	31486-31488	9499427	denotes	54
T14498	31489-31491	15051956	denotes	55
T43820	31829-31831	11591824	denotes	56
T23359	32402-32404	16581510	denotes	16
T49356	34179-34181	16581510	denotes	16
T34832	34182-34184	16809775	denotes	57
T3513	34185-34187	15536132	denotes	58
T32462	35292-35294	9488723	denotes	59
T24159	37461-37463	10973068	denotes	46
T70599	37799-37801	16580996	denotes	17
T59070	40376-40378	15120994	denotes	60
T69293	41459-41461	11040213	denotes	31
T5659	42248-42250	16488114	denotes	36
T28965	42692-42694	15502814	denotes	61
T55782	43378-43380	11084626	denotes	62
T5457	44631-44633	11040213	denotes	31
T23284	46720-46722	12609607	denotes	23
T29559	50428-50430	14769957	denotes	63
T14023	50528-50530	16581510	denotes	16
T63628	50678-50680	16581510	denotes	16
T61380	50681-50683	14769957	denotes	63

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T3640	7927-7938	NCBITaxon:8088	denotes	Medaka fish
T3641	7948-7953	NCBITaxon:9606	denotes	Human
T3642	7954-7959	PR:000006542	denotes	DMRT1
T3643	7971-7980	GO:0030849	denotes	autosomal
T700	1483-1488	PR:000006549	denotes	Dmrt7
T701	1515-1520	PR:000006549	denotes	DMRT7
T702	1541-1554	GO:0001739	denotes	sex chromatin
T703	1545-1569	GO:0016568	denotes	chromatin transformation
T704	1590-1599	GO:0000239	denotes	pachynema
T645	2-8	NCBITaxon:40674	denotes	Mammal
T646	18-27	PR:P23023	denotes	Doublesex
T647	28-35	SO:0000853	denotes	Homolog
T648	57-70	GO:0001739	denotes	Sex Chromatin
T649	91-103	GO:0007140	denotes	Male Meiosis
T650	150-163	GO:0007276	denotes	Gametogenesis
T651	230-239	CL:0000586	denotes	germ cell
T652	235-255	GO:0030154	denotes	cell differentiation
T653	278-285	NCBITaxon:40674	denotes	mammals
T654	317-332	GO:0000803	denotes	sex chromosomes
T655	407-408	GO:0000805	denotes	X
T656	413-414	GO:0000806	denotes	Y
T657	430-437	GO:0007126	denotes	meiotic
T658	438-446	GO:0051324	denotes	prophase
T659	462-474	_FRAGMENT	denotes	formation of
T660	477-499	GO:0031507	denotes	heterochromatin domain
T661	477-492	GO:0000792	denotes	heterochromatin
T662	505-512	GO:0001741	denotes	XY body
T663	518-525	GO:0001741	denotes	XY body
T664	545-553	GO:0051324	denotes	prophase
T665	571-584	GO:0001739	denotes	sex chromatin
T666	630-637	GO:0007126	denotes	meiosis
T667	676-681	PR:000006549	denotes	DMRT7
T668	685-691	NCBITaxon:40674	denotes	mammal
T669	755-764	PR:P23023	denotes	Doublesex
T670	769-774	PR:O18214	denotes	MAB-3
T671	789-794	PR:000006549	denotes	DMRT7
T672	827-834	GO:0001741	denotes	XY body
T673	842-851	GO:0000239	denotes	pachytene
T674	861-868	GO:0007126	denotes	meiotic
T675	869-877	GO:0051324	denotes	prophase
T676	898-910	GO:0007140	denotes	male meiosis
T677	915-920	PR:000006549	denotes	Dmrt7
T678	930-945	GO:0007129	denotes	meiotic pairing
T679	985-1011	GO:0006342	denotes	transcriptionally silenced
T680	1012-1019	GO:0001741	denotes	XY body
T681	1037-1046	GO:0000785	denotes	chromatin
T682	1073-1083	CL:0000586	denotes	germ cells
T683	1092-1101	GO:0006915	denotes	apoptosis
T684	1109-1118	GO:0000239	denotes	pachynema
T685	1163-1172	GO:0000240	denotes	diplonema
T686	1221-1234	GO:0001739	denotes	sex chromatin
T687	1243-1250	PR:000043452	denotes	histone
T688	1243-1250	CHEBI:15358	denotes	histone
T689	1243-1259	_FRAGMENT	denotes	histone H3K9 di-
T690	1267-1278	GO:0036123	denotes	methylation
T691	1243-1255	_FRAGMENT	denotes	histone H3K9
T692	1264-1278	GO:0036124	denotes	trimethylation
T693	1283-1298	GO:0000792	denotes	heterochromatin
T694	1283-1309	PR:000005082	denotes	heterochromatin protein 1β
T695	1366-1375	GO:0000239	denotes	pachynema
T696	1380-1389	GO:0000240	denotes	diplonema
T697	1420-1425	PR:000006549	denotes	DMRT7
T698	1433-1440	GO:0001741	denotes	XY body
T699	1449-1462	GO:0001739	denotes	sex chromatin
T705	1604-1613	GO:0000240	denotes	diplonema
T706	1631-1636	PR:000006549	denotes	DMRT7
T707	1646-1653	GO:0065007	denotes	control
T708	1674-1681	GO:0007126	denotes	meiotic
T709	1682-1696	GO:0000803	denotes	sex chromosome
T710	1717-1724	GO:0007126	denotes	meiotic
T711	1725-1738	GO:0001739	denotes	sex chromatin
T712	1801-1808	NCBITaxon:40674	denotes	mammals
T713	1827-1838	NCBITaxon:7742	denotes	vertebrates
T714	1840-1845	PR:000006549	denotes	Dmrt7
T715	1877-1884	GO:0007126	denotes	meiosis
T716	1892-1905	GO:0001739	denotes	sex chromatin
T3644	8041-8051	UBERON:0000473	denotes	testicular
T3541	5088-5095	NCBITaxon:40674	denotes	mammals
T3542	5172-5182	GO:0010467	denotes	expression
T3543	5197-5202	SO:0000704	denotes	genes
T3544	5231-5238	NCBITaxon:40674	denotes	mammals
T3545	5258-5270	GO:0000805	denotes	X chromosome
T3546	5258-5283	GO:0009048	denotes	X chromosome inactivation
T3547	5305-5320	CL:0000015	denotes	male germ cells
T3548	5372-5379	GO:0007126	denotes	meiosis
T3549	5384-5394	GO:0007128	denotes	prophase I
T3492	3096-3118	GO:0007548	denotes	Sexual differentiation
T3493	3129-3139	UBERON:0001062	denotes	anatomical
T3494	3206-3225	GO:0019953	denotes	sexual reproduction
T3495	3260-3273	CL:0002371	denotes	somatic cells
T3496	3329-3348	GO:0019953	denotes	sexual reproduction
T3497	3366-3373	CL:0000300	denotes	gametes
T3498	3386-3393	CL:0000300	denotes	Gametes
T3499	3511-3517	CL:0000365	denotes	zygote
T3500	3511-3527	GO:0009566	denotes	zygote formation
T3501	3559-3566	CL:0000300	denotes	gametes
T3502	3633-3640	CL:0000300	denotes	gametes
T3503	3677-3686	NCBITaxon:40674	denotes	Mammalian
T3504	3687-3694	GO:0007126	denotes	meiosis
T3505	3698-3707	GO:0065007	denotes	regulated
T3506	3737-3750	GO:0009790	denotes	embryogenesis
T3507	3782-3792	UBERON:0000113	denotes	adult life
T3508	3853-3860	GO:0007126	denotes	meiosis
T3509	3910-3920	CL:0000586	denotes	germ cells
T3510	3944-3951	GO:0007126	denotes	meiosis
T3511	3959-3965	UBERON:0000922	denotes	embryo
T3512	3984-4002	GO:0007128	denotes	meiotic prophase I
T3513	4019-4026	CL:0000023	denotes	oocytes
T3514	4057-4066	GO:0030728	denotes	ovulation
T3515	4089-4101	GO:0007137	denotes	metaphase II
T3516	4120-4127	GO:0007126	denotes	meiosis
T3517	4134-4147	GO:0009566	denotes	fertilization
T3518	4173-4185	GO:0007140	denotes	male meiosis
T3519	4206-4213	GO:0007567	denotes	natally
T3520	4277-4284	GO:0007126	denotes	meiosis
T3521	4314-4320	CL:0000023	denotes	oocyte
T3522	4367-4379	GO:0007140	denotes	male meiosis
T3523	4405-4418	CL:0000017	denotes	spermatocytes
T3524	4426-4433	GO:0007126	denotes	meiotic
T3525	4471-4489	GO:0007129	denotes	chromosome pairing
T3526	4491-4499	GO:0007129	denotes	synapsis
T3527	4604-4622	GO:0007143	denotes	meiosis in females
T3528	4629-4634	NCBITaxon:9606	denotes	human
T3529	4635-4641	CL:0000023	denotes	oocyte
T3530	4688-4693	NCBITaxon:9606	denotes	human
T3531	4694-4699	CL:0000019	denotes	sperm
T3532	4736-4747	GO:0000075	denotes	checkpoints
T3533	4748-4759	GO:0065007	denotes	controlling
T3534	4764-4774	GO:0065007	denotes	monitoring
T3535	4789-4796	GO:0007126	denotes	meiotic
T3536	4865-4872	SO:0000704	denotes	genetic
T3537	4897-4915	GO:0040020	denotes	meiotic regulatory
T3538	4916-4921	SO:0000704	denotes	genes
T3539	4929-4934	NCBITaxon:10088	denotes	mouse
T3540	5043-5058	GO:0000803	denotes	sex chromosomes
T3550	5428-5435	GO:0007129	denotes	synapse
T3551	5473-5474	_FRAGMENT	denotes	X
T3552	5481-5491	GO:0000805	denotes	chromosome
T3553	5479-5491	GO:0000806	denotes	Y chromosome
T3554	5481-5499	GO:0007129	denotes	chromosome pairing
T3555	5613-5622	_FRAGMENT	denotes	eutherian
T3556	5637-5644	NCBITaxon:9347	denotes	mammals
T3557	5627-5644	NCBITaxon:9263	denotes	marsupial mammals
T3558	5714-5723	GO:0000785	denotes	chromatin
T3559	5742-5749	GO:0001741	denotes	XY body
T3560	5753-5761	GO:0001741	denotes	sex body
T3561	5783-5790	GO:0001741	denotes	XY body
T3562	5859-5871	GO:0007140	denotes	male meiotic
T3563	5939-5946	GO:0001741	denotes	XY body
T3564	5958-5963	PR:000004803	denotes	BRCA1
T3565	5965-5968	PR:000004499	denotes	ATR
T3566	5974-5981	PR:000043452	denotes	histone
T3567	5974-5981	CHEBI:15358	denotes	histone
T3568	5990-5994	PR:000008425	denotes	H3.3
T3569	6009-6017	PR:000043452	denotes	histones
T3570	6009-6017	CHEBI:15358	denotes	histones
T3571	6040-6043	PR:000027547	denotes	H2A
T3572	6048-6051	PR:000027547	denotes	H2A
T3573	6072-6076	PR:000008418	denotes	H2AX
T3574	6101-6108	GO:0001741	denotes	XY body
T3575	6114-6129	GO:0000803	denotes	sex chromosomes
T3576	6134-6160	GO:0006342	denotes	transcriptionally silenced
T3577	6181-6188	GO:0007126	denotes	meiotic
T3578	6189-6203	GO:0000803	denotes	sex chromosome
T3579	6229-6236	GO:0001741	denotes	XY body
T3580	6254-6263	GO:0000239	denotes	pachynema
T3581	6290-6295	SO:0000704	denotes	genes
T3582	6303-6327	GO:0006342	denotes	transcriptionally silent
T3583	6333-6347	GO:0007286	denotes	spermiogenesis
T3584	6374-6383	GO:0016458	denotes	silencing
T3585	6421-6430	GO:0000785	denotes	chromatin
T3586	6451-6464	GO:0001739	denotes	sex chromatin
T3587	6483-6490	GO:0007126	denotes	meiotic
T3588	6491-6504	GO:0001739	denotes	sex chromatin
T3589	6535-6557	GO:0007548	denotes	sexual differentiation
T3590	6594-6603	NCBITaxon:1	denotes	organisms
T3591	6750-6758	GO:0065007	denotes	regulate
T3592	6759-6781	GO:0007548	denotes	sexual differentiation
T3593	6810-6815	NCBITaxon:phylum	denotes	phyla
T3594	6846-6851	SO:0000704	denotes	genes
T3595	6863-6872	PR:P23023	denotes	doublesex
T3596	6874-6877	PR:P23023	denotes	dsx
T3597	6882-6892	NCBITaxon:7215	denotes	Drosophila
T3598	6908-6917	PR:P23023	denotes	Doublesex
T3599	6918-6923	PR:O18214	denotes	MAB-3
T3600	6956-6962	SO:0000417	denotes	domain
T3601	6975-6981	SO:0000417	denotes	domain
T3602	6991-6996	SO:0000704	denotes	genes
T3603	7016-7024	GO:0065007	denotes	regulate
T3604	7044-7066	GO:0007548	denotes	sexual differentiation
T3605	7070-7077	NCBITaxon:6960	denotes	insects
T3606	7079-7088	NCBITaxon:6231	denotes	nematodes
T3607	7094-7101	NCBITaxon:40674	denotes	mammals
T3608	7112-7117	PR:O18214	denotes	mab-3
T3609	7118-7122	SO:0000704	denotes	gene
T3610	7126-7148	NCBITaxon:6239	denotes	Caenorhabditis elegans
T3611	7191-7194	PR:P23023	denotes	DSX
T3612	7255-7274	PR:P23023-1	denotes	male isoform of DSX
T3613	7260-7267	SO:0001060	denotes	isoform
T3614	7332-7337	SO:0000704	denotes	genes
T3615	7384-7390	SO:0000417	denotes	domain
T3616	7420-7431	NCBITaxon:7742	denotes	Vertebrates
T3617	7445-7451	SO:0000417	denotes	domain
T3618	7452-7457	SO:0000704	denotes	genes
T3619	7520-7525	SO:0000704	denotes	genes
T3620	7531-7538	GO:0065007	denotes	control
T3621	7539-7561	GO:0007548	denotes	sexual differentiation
T3622	7563-7570	NCBITaxon:40674	denotes	Mammals
T3623	7585-7591	SO:0000417	denotes	domain
T3624	7592-7597	SO:0000704	denotes	genes
T3625	7604-7609	SO:0000704	denotes	genes
T3626	7661-7671	GO:0010467	denotes	expression
T3627	7707-7712	SO:0000704	denotes	genes
T3628	7714-7719	PR:000006542	denotes	Dmrt1
T3629	7724-7733	GO:0010467	denotes	expressed
T3630	7762-7776	UBERON:0005294	denotes	genital ridges
T3631	7781-7786	UBERON:0007023	denotes	adult
T3632	7787-7793	UBERON:0000473	denotes	testis
T3633	7797-7804	NCBITaxon:40674	denotes	mammals
T3634	7806-7811	NCBITaxon:8782	denotes	birds
T3635	7859-7864	PR:000006542	denotes	Dmrt1
T3636	7865-7869	SO:0000704	denotes	gene
T3637	7887-7888	GO:0000806	denotes	Y
T3638	7896-7902	UBERON:0000473	denotes	testis
T3639	7915-7919	SO:0000704	denotes	gene
T3645	8041-8063	GO:0008584	denotes	testicular development
T3646	8112-8116	NCBITaxon:10088	denotes	mice
T3647	8151-8156	PR:000006542	denotes	Dmrt1
T3648	8180-8186	UBERON:0000473	denotes	testis
T3649	8218-8228	CL:0000586	denotes	germ cells
T3650	8233-8246	CL:0000216	denotes	Sertoli cells
T3651	8260-8264	NCBITaxon:10088	denotes	mice
T3652	8275-8280	PR:000006545	denotes	Dmrt4
T3653	8290-8296	CL:0000025	denotes	ovular
T3654	8329-8333	SO:0000704	denotes	gene
T3655	8355-8362	UBERON:0000991	denotes	gonadal
T3656	8355-8374	GO:0008406	denotes	gonadal development
T3657	8438-8444	SO:0000417	denotes	domain
T3658	8445-8450	SO:0000704	denotes	genes
T3659	8454-8476	GO:0007548	denotes	sexual differentiation
T3660	8512-8522	NCBITaxon:7742	denotes	vertebrate
T3661	8528-8532	SO:0000704	denotes	gene
T3662	8560-8582	GO:0007548	denotes	sexual differentiation
T3663	8584-8589	PR:000006543	denotes	Dmrt2
T3664	8636-8640	NCBITaxon:10088	denotes	mice
T3665	8690-8700	GO:0010467	denotes	expression
T3666	8721-8726	PR:000006549	denotes	Dmrt7
T3667	8727-8731	SO:0000704	denotes	gene
T3668	8739-8744	NCBITaxon:10088	denotes	mouse
T3669	8746-8751	PR:000006549	denotes	Dmrt7
T3670	8755-8764	GO:0010467	denotes	expressed
T3671	8777-8782	UBERON:0000991	denotes	gonad
T3672	8811-8816	SO:0000704	denotes	genes
T3673	8855-8862	NCBITaxon:40674	denotes	mammals
T3674	8877-8886	NCBITaxon:40674	denotes	mammalian
T3675	8887-8898	NCBITaxon:7742	denotes	vertebrates
T3676	8921-8926	PR:000006549	denotes	DMRT7
T3677	8938-8947	GO:0010467	denotes	expressed
T3678	8956-8966	CL:0000586	denotes	germ cells
T3679	9003-9010	GO:0001741	denotes	XY body
T3680	9014-9018	_FRAGMENT	denotes	male
T3681	9029-9039	CL:0000015	denotes	germ cells
T3682	9019-9028	GO:0000239	denotes	pachytene
T3683	9107-9112	PR:000006549	denotes	Dmrt7
T3684	9120-9125	NCBITaxon:10088	denotes	mouse
T3685	9140-9145	PR:000006549	denotes	Dmrt7
T3686	9194-9203	GO:0000239	denotes	pachytene
T3687	9213-9220	GO:0007126	denotes	meiotic
T3688	9221-9229	GO:0051324	denotes	prophase
T3689	9299-9308	GO:0000240	denotes	diplonema
T3690	9322-9335	GO:0001739	denotes	sex chromatin
T3691	9396-9401	PR:000006549	denotes	Dmrt7
T3692	9443-9452	GO:0000785	denotes	chromatin
T3693	9443-9463	GO:0016568	denotes	chromatin transition
T3694	9472-9481	GO:0000239	denotes	pachynema
T3695	9486-9495	GO:0000240	denotes	diplonema
T3696	9503-9510	GO:0007126	denotes	meiotic
T3697	9511-9519	GO:0051324	denotes	prophase
T6538	11777-11782	CL:0000019	denotes	sperm
T6539	11815-11824	CL:0000586	denotes	germ cell
T6540	11841-11854	CL:0000020	denotes	spermatogonia
T6541	11865-11875	CL:0000018	denotes	spermatids
T6542	11895-11900	PR:000006549	denotes	DMRT7
T6543	11912-11925	CL:0002371	denotes	somatic cells
T6544	11934-11947	CL:0000216	denotes	Sertoli cells
T6545	11949-11972	CL:0002481	denotes	peritubular myoid cells
T6546	11953-11960	UBERON:0000025	denotes	tubular
T6547	11977-11989	CL:0000178	denotes	Leydig cells
T6548	12023-12032	GO:0000239	denotes	pachytene
T6549	12043-12048	PR:000006549	denotes	DMRT7
T6489	9531-9541	GO:0010467	denotes	Expression
T6490	9545-9550	PR:000006549	denotes	DMRT7
T6491	9563-9569	UBERON:0000473	denotes	Testis
T6492	9588-9598	GO:0010467	denotes	expression
T6493	9629-9636	GO:0007126	denotes	meiotic
T6494	9650-9655	PR:000006549	denotes	Dmrt7
T6495	9670-9680	GO:0010467	denotes	expression
T6496	9684-9689	PR:000006549	denotes	Dmrt7
T6497	9708-9714	UBERON:0000991	denotes	gonads
T6498	9751-9756	UBERON:0000992	denotes	ovary
T6499	9758-9763	PR:000006549	denotes	Dmrt7
T6500	9835-9842	GO:0007126	denotes	meiosis
T6501	9859-9882	GO:0006279	denotes	pre-meiotic replication
T6502	9890-9899	GO:0000239	denotes	pachytene
T6503	9919-9924	PR:000006549	denotes	Dmrt7
T6504	9925-9935	GO:0010467	denotes	expression
T6505	9947-9954	GO:0007126	denotes	meiotic
T6506	9961-9967	UBERON:0000473	denotes	testis
T6507	10024-10029	UBERON:0007023	denotes	adult
T6508	10030-10035	PR:000006549	denotes	Dmrt7
T6509	10036-10046	GO:0010467	denotes	expression
T6510	10115-10120	UBERON:0007023	denotes	adult
T6511	10121-10127	UBERON:0000062	denotes	organs
T6512	10148-10153	PR:000006549	denotes	Dmrt7
T6513	10159-10169	GO:0010467	denotes	expression
T6514	10177-10183	UBERON:0000473	denotes	testis
T6515	10199-10209	GO:0010467	denotes	expression
T6516	10213-10218	UBERON:0000948	denotes	heart
T6517	10241-10247	UBERON:0000479	denotes	tissue
T6518	10294-10299	PR:000006549	denotes	Dmrt7
T6519	10305-10315	GO:0010467	denotes	expression
T6520	10327-10332	GO:0007567	denotes	natal
T6521	10333-10339	UBERON:0000473	denotes	testis
T6522	10333-10351	GO:0008584	denotes	testis development
T6523	10372-10382	GO:0010467	denotes	expression
T6524	10448-10457	GO:0000239	denotes	pachytene
T6525	10501-10516	GO:0007283	denotes	spermatogenesis
T6526	11369-11374	PR:000006549	denotes	DMRT7
T6527	11383-11393	GO:0010467	denotes	expression
T6528	11411-11419	GO:0042571	denotes	antibody
T6529	11471-11479	GO:0042571	denotes	antibody
T6530	11530-11536	SO:0000417	denotes	domain
T6531	11584-11590	SO:0000417	denotes	domain
T6532	11642-11647	PR:000006549	denotes	DMRT7
T6533	11652-11656	UBERON:0001977	denotes	sera
T6534	11669-11674	PR:000006549	denotes	DMRT7
T6535	11686-11695	GO:0010467	denotes	expressed
T6536	11726-11735	GO:0000239	denotes	pachytene
T6537	11736-11749	CL:0000017	denotes	spermatocytes
T6550	12049-12059	GO:0010467	denotes	expression
T6551	12087-12095	GO:0042571	denotes	antibody
T6552	12099-12104	PR:000007857	denotes	GATA1
T6553	12115-12124	GO:0010467	denotes	expressed
T6554	12128-12141	CL:0000216	denotes	Sertoli cells
T6555	12190-12195	PR:000006549	denotes	DMRT7
T6556	12199-12208	GO:0010467	denotes	expressed
T6557	12225-12234	GO:0000239	denotes	pachytene
T6558	12235-12248	CL:0000017	denotes	spermatocytes
T6559	12349-12358	GO:0000239	denotes	pachytene
T6560	12359-12372	CL:0000017	denotes	spermatocytes
T6561	12374-12379	PR:000006549	denotes	DMRT7
T6562	12403-12410	GO:0001741	denotes	XY body
T6563	12415-12423	GO:0001741	denotes	sex body
T6564	12444-12453	GO:0000785	denotes	chromatin
T6565	12478-12493	GO:0000803	denotes	sex chromosomes
T6566	12542-12564	GO:0031507	denotes	heterochromatinization
T6567	12612-12620	GO:0051324	denotes	prophase
T6568	12624-12633	NCBITaxon:40674	denotes	mammalian
T6569	12634-12646	GO:0007140	denotes	male meiosis
T6570	12663-12668	PR:000006549	denotes	DMRT7
T6571	12677-12687	GO:0010467	denotes	expression
T6572	12695-12702	GO:0001741	denotes	XY body
T6573	12722-12727	NCBITaxon:10088	denotes	mouse
T6574	12728-12734	UBERON:0000473	denotes	testis
T6575	12748-12753	PR:000006549	denotes	DMRT7
T6576	12758-12792	PR:000015829	denotes	small ubiquitin-related modifier 1
T6577	12794-12800	PR:000015829	denotes	SUMO-1
T6578	12832-12839	GO:0001741	denotes	XY body
T6579	12847-12856	GO:0000239	denotes	pachynema
T6580	12866-12871	PR:000006549	denotes	DMRT7
T6581	12876-12882	PR:000015829	denotes	SUMO-1
T6582	12917-12922	PR:000006549	denotes	DMRT7
T6583	12966-12973	GO:0001741	denotes	XY body
T6584	13005-13012	GO:0001741	denotes	XY body
T6585	13029-13034	PR:000006549	denotes	DMRT7
T6586	13085-13088	PR:000027547	denotes	H2A
T6587	13119-13124	PR:000006549	denotes	DMRT7
T6588	13164-13171	GO:0001741	denotes	XY body
T6589	13219-13229	UBERON:0000483	denotes	epithelial
T6590	13255-13260	PR:000006549	denotes	DMRT7
T6591	13278-13285	GO:0001741	denotes	XY body
T6592	13304-13313	GO:0000239	denotes	pachynema
T6593	13353-13362	GO:0000239	denotes	pachynema
T6594	13382-13391	GO:0000240	denotes	diplonema
T6595	13459-13466	GO:0007126	denotes	meiotic
T6596	13488-13493	PR:000006549	denotes	DMRT7
T6597	13528-13533	CL:0000019	denotes	sperm
T6598	13540-13548	GO:0042571	denotes	antibody
T6599	13576-13583	GO:0005634	denotes	nuclear
T6600	13596-13601	CL:0000019	denotes	sperm
T6601	13607-13616	GO:0002177	denotes	manchette
T6602	13651-13661	UBERON:0000483	denotes	epithelial
T6603	13678-13683	PR:000006549	denotes	DMRT7
T6604	13701-13708	GO:0001741	denotes	XY body
T6605	13712-13725	CL:0000017	denotes	spermatocytes
T8053	15029-15035	SO:0001023	denotes	allele
T8005	13768-13773	PR:000006549	denotes	Dmrt7
T8006	13818-13823	PR:000006549	denotes	Dmrt7
T8007	13838-13843	PR:000006549	denotes	Dmrt7
T8008	13848-13852	NCBITaxon:10088	denotes	mice
T8009	13879-13888	UBERON:0000922	denotes	embryonic
T8010	13879-13893	_FRAGMENT	denotes	embryonic stem
T8011	13899-13904	CL:0002322	denotes	cells
T8012	13895-13897	_FRAGMENT	denotes	ES
T8013	13952-13957	PR:000006549	denotes	Dmrt7
T8014	13958-13962	SO:0000704	denotes	gene
T8015	13972-13977	SO:0000147	denotes	exons
T8016	13990-13996	SO:0000417	denotes	domain
T8017	14029-14034	SO:0000147	denotes	exons
T8018	14051-14057	SO:0000417	denotes	domain
T8019	14093-14098	SO:0000704	denotes	genes
T8020	14110-14115	PR:O18214	denotes	mab-3
T8021	14129-14132	PR:P23023	denotes	dsx
T8022	14184-14190	SO:0000359	denotes	floxed
T8023	14192-14198	SO:0001023	denotes	allele
T8024	14215-14221	SO:0000417	denotes	domain
T8025	14233-14238	SO:0000147	denotes	exons
T8026	14242-14247	PR:000006549	denotes	Dmrt7
T8027	14252-14259	SO:0000357	denotes	flanked
T8028	14306-14316	SO:0000346	denotes	loxP sites
T8029	14323-14339	SO:0001644	denotes	targeting vector
T8030	14357-14365	CHEBI:7507	denotes	neomycin
T8031	14377-14385	SO:0005853	denotes	cassette
T8032	14392-14399	SO:0000357	denotes	flanked
T8033	14403-14425	SO:0000350	denotes	Flpe recognition sites
T8034	14506-14512	SO:0000417	denotes	domain
T8035	14521-14540	GO:0006413	denotes	translational start
T8036	14521-14545	SO:0000318	denotes	translational start site
T8037	14579-14585	SO:0001023	denotes	allele
T8038	14629-14636	CL:0002322	denotes	ES cell
T8039	14726-14737	UBERON:0000358	denotes	blastocysts
T8040	14748-14755	NCBITaxon:33208	denotes	animals
T8041	14802-14808	SO:0001023	denotes	allele
T8042	14841-14848	NCBITaxon:33208	denotes	animals
T8043	14862-14869	PR:000003676	denotes	β-actin
T8044	14874-14878	NCBITaxon:10088	denotes	mice
T8045	14896-14902	SO:0000417	denotes	domain
T8046	14912-14917	SO:0000147	denotes	exons
T8047	14934-14939	PR:000006549	denotes	Dmrt7
T8048	14941-14947	SO:0001023	denotes	allele
T8049	14971-14975	NCBITaxon:10088	denotes	mice
T8050	14994-15002	SO:0005853	denotes	cassette
T8051	15019-15024	PR:000006549	denotes	Dmrt7
T8052	15024-15028	SO:0000359	denotes	flox
T8054	15037-15042	PR:000006549	denotes	Dmrt7
T8055	15046-15050	NCBITaxon:10088	denotes	mice
T8056	15078-15083	PR:000006549	denotes	Dmrt7
T8057	15087-15091	NCBITaxon:10088	denotes	mice
T8058	15127-15132	PR:000006549	denotes	DMRT7
T8059	15144-15149	PR:000006549	denotes	Dmrt7
T8060	15152-15158	UBERON:0000473	denotes	testes
T8061	15171-15178	GO:0007126	denotes	meiotic
T8062	15192-15197	PR:000006549	denotes	Dmrt7
T8063	15243-15249	UBERON:0000473	denotes	testes
T8064	15350-15355	PR:000006549	denotes	DMRT7
T8065	15378-15384	UBERON:0000473	denotes	testes
T9582	19066-19072	UBERON:0000473	denotes	testes
T9583	19107-19119	CL:0002371	denotes	somatic cell
T9584	19115-19129	GO:0006915	denotes	cell apoptosis
T9585	19206-19211	PR:000006549	denotes	Dmrt7
T9586	19230-19237	GO:0007126	denotes	meiotic
T9587	19261-19270	GO:0000239	denotes	pachynema
T9588	19303-19312	GO:0006915	denotes	apoptosis
T9510	15387-15392	PR:000006549	denotes	Dmrt7
T9511	15409-15413	_FRAGMENT	denotes	Male
T9512	15429-15442	GO:0048232	denotes	Gametogenesis
T9513	15422-15442	GO:0007292	denotes	Female Gametogenesis
T9514	15455-15460	PR:000006549	denotes	Dmrt7
T9515	15613-15617	GO:0040007	denotes	grew
T9516	15621-15630	UBERON:0000113	denotes	adulthood
T9517	15662-15677	GO:0019098	denotes	sexual behavior
T9518	15764-15771	UBERON:0000992	denotes	ovarian
T9519	15854-15859	PR:000006549	denotes	Dmrt7
T9520	15918-15924	UBERON:0000473	denotes	testes
T9521	15990-15995	UBERON:0007023	denotes	adult
T9522	16048-16054	UBERON:0000473	denotes	testis
T9523	16048-16066	GO:0008584	denotes	testis development
T9524	16077-16082	PR:000006549	denotes	Dmrt7
T9525	16108-16114	UBERON:0000473	denotes	testes
T9526	16176-16191	GO:0007283	denotes	spermatogenesis
T9527	16206-16211	GO:0007567	denotes	natal
T9528	16233-16239	UBERON:0000473	denotes	testes
T9529	16279-16285	UBERON:0000473	denotes	testis
T9530	16375-16388	CL:0000020	denotes	spermatogonia
T9531	16399-16406	GO:0007126	denotes	meiotic
T9532	16407-16417	CL:0000586	denotes	germ cells
T9533	16479-16485	UBERON:0000473	denotes	testes
T9534	16493-16498	PR:000006549	denotes	Dmrt7
T9535	16506-16510	NCBITaxon:10088	denotes	mice
T9536	16521-16525	GO:0040007	denotes	grow
T9537	16608-16613	PR:000006549	denotes	Dmrt7
T9538	16621-16627	UBERON:0000473	denotes	testes
T9539	16642-16652	CL:0000586	denotes	germ cells
T9540	16663-16672	GO:0000239	denotes	pachynema
T9541	16684-16693	_FRAGMENT	denotes	stages of
T9542	16699-16704	GO:0022403	denotes	cells
T9543	16694-16704	CL:0000586	denotes	germ cells
T9544	16745-16750	PR:000006549	denotes	Dmrt7
T9545	16758-16762	NCBITaxon:10088	denotes	mice
T9546	16784-16791	GO:0007126	denotes	meiotic
T9547	16792-16802	CL:0000018	denotes	spermatids
T9548	16812-16822	UBERON:0001301	denotes	epididymal
T9549	16823-16834	CL:0000019	denotes	spermatozoa
T9550	16878-16887	CL:0000018	denotes	spermatid
T9551	16901-16908	GO:0007126	denotes	meiotic
T9552	16980-16985	PR:000006549	denotes	Dmrt7
T9553	17012-17017	PR:000006549	denotes	Dmrt7
T9554	17025-17032	UBERON:0000025	denotes	tubules
T9555	17077-17090	CL:0000216	denotes	Sertoli cells
T9556	17095-17108	CL:0000020	denotes	spermatogonia
T9557	17131-17152	CL:0000656	denotes	primary spermatocytes
T9558	17172-17179	UBERON:0000025	denotes	tubules
T9559	17188-17208	CL:0000228	denotes	multinucleated cells
T9560	17193-17202	GO:0005634	denotes	nucleated
T9561	17213-17223	_FRAGMENT	denotes	cells with
T9562	17239-17245	CL:0002242	denotes	nuclei
T9563	17239-17245	GO:0005634	denotes	nuclei
T9564	17266-17281	CL:0000445	denotes	apoptotic cells
T9565	18318-18323	PR:000006549	denotes	Dmrt7
T9566	18331-18337	UBERON:0000473	denotes	testes
T9567	18353-18362	GO:0000239	denotes	pachytene
T9568	18445-18454	GO:0006915	denotes	apoptosis
T9569	18465-18470	PR:000006549	denotes	Dmrt7
T9570	18478-18484	UBERON:0000473	denotes	testes
T9571	18512-18527	CL:0000445	denotes	apoptotic cells
T9572	18580-18586	UBERON:0000025	denotes	tubule
T9573	18624-18630	GO:0005634	denotes	nuclei
T9574	18663-18668	PR:000006549	denotes	Dmrt7
T9575	18752-18761	GO:0006915	denotes	apoptosis
T9576	18785-18791	UBERON:0000473	denotes	testes
T9577	18830-18845	CL:0000445	denotes	apoptotic cells
T9578	18872-18879	UBERON:0000025	denotes	tubules
T9579	18893-18908	CL:0000445	denotes	apoptotic cells
T9580	18944-18963	UBERON:0001343	denotes	seminiferous tubule
T9581	18990-19003	CL:0000216	denotes	Sertoli cells
T10836	19338-19347	GO:0000239	denotes	Pachytene
T10837	19358-19363	PR:000006549	denotes	Dmrt7
T10838	19371-19381	CL:0000586	denotes	Germ Cells
T10839	19403-19416	GO:0007283	denotes	spermatogenic
T10840	19432-19437	PR:000006549	denotes	Dmrt7
T10841	19441-19456	CL:0000015	denotes	male germ cells
T10842	19468-19471	GO:0016265	denotes	die
T10843	19481-19491	GO:0042571	denotes	antibodies
T10844	19523-19532	CL:0000586	denotes	germ cell
T10845	19551-19560	GO:0010467	denotes	expressed
T10846	19564-19568	CL:0000670	denotes	PGCs
T10847	19573-19586	CL:0000020	denotes	spermatogonia
T10848	19610-19615	UBERON:0007023	denotes	adult
T10849	19616-19622	UBERON:0000473	denotes	testis
T10850	19781-19788	UBERON:0000025	denotes	tubules
T10851	19841-19849	GO:0042571	denotes	antibody
T10852	19861-19874	CL:0000017	denotes	spermatocytes
T10853	19882-19891	GO:0000237	denotes	leptotene
T10854	19901-19910	GO:0000239	denotes	pachytene
T10855	19924-19929	PR:000006549	denotes	Dmrt7
T10856	19937-19943	UBERON:0000473	denotes	testes
T10857	20104-20111	UBERON:0000025	denotes	tubules
T10858	20136-20144	GO:0042571	denotes	antibody
T10859	20158-20166	PR:000005573	denotes	calmegin
T10860	20175-20184	GO:0010467	denotes	expressed
T10861	20188-20197	GO:0000239	denotes	pachytene
T10862	20198-20211	CL:0000017	denotes	spermatocytes
T10863	20230-20240	CL:0000018	denotes	spermatids
T10864	20337-20343	UBERON:0000473	denotes	testes
T10865	20427-20440	GO:0098762	denotes	meiotic stage
T10866	20447-20459	CL:0000017	denotes	spermatocyte
T10867	20478-20496	GO:0007129	denotes	chromosome-pairing
T10868	20520-20525	PR:000015865	denotes	SYCP3
T10869	20546-20566	GO:0000795	denotes	synaptonemal complex
T10870	20593-20598	PR:000006549	denotes	Dmrt7
T10871	20618-20627	GO:0000239	denotes	pachytene
T10872	20684-20693	GO:0000239	denotes	pachynema
T10873	20747-20754	GO:0007126	denotes	meiotic
T10874	20765-20770	PR:000006549	denotes	Dmrt7
T10875	20803-20812	GO:0000239	denotes	pachynema
T11673	21690-21697	GO:0007126	denotes	Meiotic
T11674	21698-21706	GO:0051324	denotes	Prophase
T11675	21710-21715	PR:000006549	denotes	Dmrt7
T11676	21723-21733	CL:0000586	denotes	Germ Cells
T11677	21745-21763	GO:0007129	denotes	chromosome pairing
T11678	21765-21773	GO:0007129	denotes	synapsis
T11679	21804-21813	GO:0000239	denotes	pachytene
T11680	21825-21834	GO:0006915	denotes	apoptosis
T11681	21879-21884	PR:000006549	denotes	Dmrt7
T11682	21892-21898	UBERON:0000473	denotes	testes
T11683	21918-21926	GO:0007129	denotes	synapsis
T11684	21936-21946	GO:0042571	denotes	antibodies
T11685	21950-21955	PR:000015862	denotes	SYCP1
T11686	21959-21979	GO:0000795	denotes	synaptonemal complex
T11687	21980-21998	GO:0000802	denotes	transverse element
T11688	22014-22019	PR:000015865	denotes	SYCP3
T11689	22040-22053	GO:0000800	denotes	axial element
T11690	22078-22086	GO:0007129	denotes	synapsed
T11691	22099-22108	GO:0000240	denotes	diplonema
T11692	22118-22153	GO:0007130	denotes	Formation of synaptonemal complexes
T11693	22131-22153	GO:0000795	denotes	synaptonemal complexes
T11694	22257-22262	PR:000015862	denotes	SYCP1
T11695	22286-22291	PR:000015865	denotes	SYCP3
T11696	22319-22324	PR:000006549	denotes	Dmrt7
T11697	22332-22340	GO:0000238	denotes	zygotene
T11698	22341-22354	CL:0000017	denotes	spermatocytes
T11699	22395-22415	GO:0000725	denotes	recombination repair
T11700	22423-22428	PR:000013672	denotes	RAD51
T11701	22452-22459	GO:0007126	denotes	meiotic
T11702	22517-22522	PR:000006549	denotes	Dmrt7
T11703	22530-22543	CL:0000017	denotes	spermatocytes
T11704	22594-22599	PR:000013672	denotes	RAD51
T11705	22625-22634	GO:0030849	denotes	autosomal
T11706	22635-22657	GO:0000795	denotes	synaptonemal complexes
T11707	22741-22750	GO:0000239	denotes	pachynema
T11708	22786-22794	GO:0007129	denotes	synapsis
T11709	22802-22811	GO:0000240	denotes	diplonema
T11710	22862-22881	GO:0007129	denotes	chromosomal pairing
T11711	22883-22891	GO:0007129	denotes	synapsis
T11712	22914-22922	GO:0007129	denotes	synapsis
T11713	22930-22940	GO:0007128	denotes	prophase I
T11714	22944-22949	PR:000006549	denotes	Dmrt7
T12899	24194-24199	GO:0007567	denotes	natal
T12900	24200-24213	CL:0000216	denotes	Sertoli cells
T12901	24219-24224	PR:000007857	denotes	GATA1
T12902	24235-24247	CL:0000216	denotes	Sertoli cell
T12903	24366-24374	CHEBI:50113	denotes	androgen
T12904	24444-24457	CL:0000216	denotes	Sertoli cells
T12882	23700-23713	CL:0000216	denotes	Sertoli Cells
T12883	23714-23727	CL:0000216	denotes	Sertoli cells
T12884	23742-23752	CL:0000586	denotes	germ cells
T12885	23760-23775	GO:0007283	denotes	spermatogenesis
T12886	23812-23821	CL:0000586	denotes	germ cell
T12887	23817-23832	GO:0048469	denotes	cell maturation
T12888	23866-23871	PR:000006549	denotes	DMRT7
T12889	23872-23882	GO:0010467	denotes	expression
T12890	23886-23899	CL:0000216	denotes	Sertoli cells
T12891	23903-23911	GO:0042571	denotes	antibody
T12892	23970-23982	CL:0000216	denotes	Sertoli cell
T12893	24050-24055	PR:000006549	denotes	Dmrt7
T12894	24081-24093	CL:0000216	denotes	Sertoli cell
T12895	24089-24109	GO:0030154	denotes	cell differentiation
T12896	24123-24133	GO:0010467	denotes	expression
T12897	24141-24153	CL:0000216	denotes	Sertoli cell
T12898	24162-24167	PR:000007859	denotes	GATA4
T12905	24461-24466	PR:000006549	denotes	Dmrt7
T12906	24474-24480	UBERON:0000473	denotes	testes
T12907	24503-24510	UBERON:0000025	denotes	tubules
T12908	24511-24516	PR:000007857	denotes	GATA1
T12909	24526-24538	CL:0000216	denotes	Sertoli cell
T12910	24534-24545	GO:0005634	denotes	cell nuclei
T12911	24643-24650	UBERON:0000025	denotes	tubules
T12912	24652-24661	_FRAGMENT	denotes	nuclei of
T12913	24679-24684	GO:0005634	denotes	cells
T12914	24666-24673	GO:0007126	denotes	meiotic
T12915	24674-24684	CL:0000586	denotes	germ cells
T12916	24689-24702	CL:0000017	denotes	spermatocytes
T12917	24751-24761	CL:0000586	denotes	germ cells
T12918	25886-25898	CL:0000216	denotes	Sertoli cell
T12919	25915-25920	PR:000006549	denotes	Dmrt7
T12920	25928-25934	UBERON:0000473	denotes	testes
T12921	25967-25976	CL:0000586	denotes	germ cell
T12922	26027-26039	CL:0000216	denotes	Sertoli cell
T12923	26087-26092	PR:000006549	denotes	Dmrt7
T12924	26105-26117	CL:0000216	denotes	Sertoli cell
T12925	26138-26142	NCBITaxon:10088	denotes	mice
T12926	26156-26162	SO:0000359	denotes	floxed
T12927	26163-26168	PR:000006549	denotes	Dmrt7
T12928	26169-26175	SO:0001023	denotes	allele
T12929	26181-26184	PR:000006459	denotes	Dhh
T12930	26200-26204	NCBITaxon:10088	denotes	mice
T12931	26215-26230	PR:000006459	denotes	Desert hedgehog
T12932	26232-26235	PR:000006459	denotes	Dhh
T12933	26237-26245	SO:0000167	denotes	promoter
T12934	26287-26300	CL:0000216	denotes	Sertoli cells
T12935	26312-26322	CL:0000586	denotes	germ cells
T12936	26345-26350	PR:000006549	denotes	Dmrt7
T12937	26354-26367	CL:0000216	denotes	Sertoli cells
T12938	26426-26436	UBERON:0000473	denotes	Testicular
T12939	26445-26452	CL:0000216	denotes	Sertoli
T12940	26463-26465	CL:0000216	denotes	SC
T12941	26475-26482	NCBITaxon:33208	denotes	animals
T12942	26607-26609	CL:0000216	denotes	SC
T12943	26618-26624	UBERON:0000473	denotes	testes
T12944	26638-26653	GO:0007283	denotes	Spermatogenesis
T12945	26678-26683	CL:0000019	denotes	sperm
T12946	26702-26704	CL:0000216	denotes	SC
T12947	26713-26717	NCBITaxon:10088	denotes	mice
T12948	26745-26750	PR:000007857	denotes	GATA1
T12949	26772-26784	CL:0000216	denotes	Sertoli cell
T12950	26780-26791	GO:0005634	denotes	cell nuclei
T12951	26894-26903	CL:0000586	denotes	germ cell
T12952	26915-26920	PR:000006549	denotes	Dmrt7
T12953	26955-26960	PR:000006549	denotes	Dmrt7
T12954	26964-26977	CL:0000216	denotes	Sertoli cells
T12955	27016-27029	CL:0000216	denotes	Sertoli cells
T12956	27061-27066	PR:000006549	denotes	Dmrt7
T14503	27657-27666	GO:0000239	denotes	pachynema
T14504	27724-27737	GO:0001739	denotes	sex chromatin
T14505	27799-27816	GO:0034399	denotes	nuclear periphery
T14506	27846-27851	PR:000006549	denotes	DMRT7
T14507	27868-27875	GO:0001741	denotes	XY body
T14508	27923-27930	GO:0001741	denotes	XY body
T14509	27931-27940	GO:0000785	denotes	chromatin
T14510	27974-27984	GO:0010467	denotes	expression
T14484	27086-27095	GO:0001741	denotes	XY Bodies
T14485	27113-27118	PR:000006549	denotes	Dmrt7
T14486	27172-27177	PR:000006549	denotes	Dmrt7
T14487	27185-27195	CL:0000586	denotes	germ cells
T14488	27228-27235	GO:0007126	denotes	meiosis
T14489	27259-27268	GO:0000239	denotes	pachynema
T14490	27301-27306	PR:000006549	denotes	Dmrt7
T14491	27363-27370	GO:0007126	denotes	meiotic
T14492	27404-27411	GO:0007126	denotes	meiotic
T14493	27412-27422	CL:0000586	denotes	germ cells
T14494	27456-27463	GO:0001741	denotes	XY body
T14495	27502-27509	GO:0007126	denotes	meiotic
T14496	27554-27559	PR:000006549	denotes	DMRT7
T14497	27574-27589	_FRAGMENT	denotes	Condensation of
T14498	27602-27613	GO:0030261	denotes	chromosomes
T14499	27594-27595	_FRAGMENT	denotes	X
T14500	27602-27613	GO:0000805	denotes	chromosomes
T14501	27600-27613	GO:0000806	denotes	Y chromosomes
T14502	27629-27637	GO:0000238	denotes	zygotene
T14511	28016-28020	PR:000008418	denotes	H2AX
T14512	28037-28040	PR:000027547	denotes	H2A
T14513	28061-28068	GO:0001741	denotes	XY body
T14514	28126-28133	GO:0001741	denotes	XY body
T14515	28137-28142	PR:000006549	denotes	DMRT7
T14516	28159-28166	GO:0007126	denotes	meiotic
T14517	28235-28245	CL:0000586	denotes	germ cells
T14518	28249-28254	PR:000006549	denotes	Dmrt7
T14519	28262-28268	UBERON:0000473	denotes	testes
T14520	28300-28306	PR:000015829	denotes	SUMO-1
T14521	28334-28340	UBERON:0000473	denotes	testis
T14522	28342-28348	PR:000015829	denotes	SUMO-1
T14523	28349-28359	GO:0010467	denotes	expression
T14524	28386-28393	GO:0001741	denotes	XY body
T14525	28411-28420	GO:0000239	denotes	pachytene
T14526	28421-28434	CL:0000017	denotes	spermatocytes
T14527	28450-28464	GO:0000803	denotes	sex chromosome
T14528	28454-28477	GO:0030261	denotes	chromosome condensation
T14529	28510-28532	GO:0007127	denotes	first meiotic division
T14530	28534-28540	PR:000015829	denotes	SUMO-1
T14531	28561-28568	GO:0001741	denotes	XY body
T14532	28576-28577	_FRAGMENT	denotes	X
T14533	28584-28595	GO:0000805	denotes	chromosomes
T14534	28582-28595	GO:0000806	denotes	Y chromosomes
T14535	28598-28605	GO:0007129	denotes	synapse
T14536	28621-28627	PR:000015829	denotes	SUMO-1
T14537	28656-28661	PR:000006549	denotes	Dmrt7
T14538	28669-28679	CL:0000586	denotes	germ cells
T14539	28735-28742	GO:0001741	denotes	XY body
T14540	28770-28777	UBERON:0000025	denotes	tubules
T14541	28802-28817	UBERON:0000119	denotes	layers of cells
T14542	28823-28829	PR:000015829	denotes	SUMO-1
T14543	28889-28903	UBERON:0000119	denotes	layer of cells
T14544	28926-28933	GO:0001741	denotes	XY body
T14545	29067-29076	GO:0000239	denotes	pachytene
T14546	29098-29101	PR:000027547	denotes	H2A
T14547	29118-29123	PR:000006549	denotes	Dmrt7
T14548	29131-29137	UBERON:0000473	denotes	testes
T14549	29148-29157	GO:0000239	denotes	pachytene
T14550	29162-29165	PR:000027547	denotes	H2A
T14551	29189-29196	GO:0001741	denotes	XY body
T14552	29205-29214	GO:0000239	denotes	pachytene
T14553	29218-29221	PR:000027547	denotes	H2A
T14554	29256-29263	GO:0005634	denotes	nucleus
T14555	29301-29308	GO:0001741	denotes	XY body
T14556	29317-29326	GO:0000239	denotes	pachytene
T14557	29327-29340	CL:0000017	denotes	spermatocytes
T14558	29359-29366	GO:0005634	denotes	nuclear
T14559	29392-29395	PR:000027547	denotes	H2A
T14560	29422-29429	GO:0001741	denotes	XY body
T14561	29433-29438	PR:000006549	denotes	Dmrt7
T14562	29502-29507	PR:000006549	denotes	Dmrt7
T14563	29515-29525	CL:0000586	denotes	germ cells
T14564	29543-29550	GO:0001741	denotes	XY body
T14565	29584-29593	GO:0000785	denotes	chromatin
T16983	31371-31372	GO:0000806	denotes	Y
T16984	31380-31384	SO:0000704	denotes	gene
T16985	31385-31389	PR:000030954	denotes	Rbmy
T16986	31428-31437	GO:0000239	denotes	pachytene
T16949	30116-30129	GO:0001739	denotes	Sex Chromatin
T16950	30133-30138	PR:000006549	denotes	Dmrt7
T16951	30146-30156	CL:0000586	denotes	Germ Cells
T16952	30170-30177	GO:0001741	denotes	XY body
T16953	30194-30203	GO:0000239	denotes	pachynema
T16954	30207-30212	PR:000006549	denotes	Dmrt7
T16955	30257-30282	GO:0006342	denotes	transcriptional silencing
T16956	30352-30357	PR:000006549	denotes	Dmrt7
T16957	30369-30378	GO:0000239	denotes	pachytene
T16958	30445-30454	GO:0000239	denotes	pachytene
T16959	30508-30518	GO:0007135	denotes	meiosis II
T16960	30523-30537	GO:0007286	denotes	spermiogenesis
T16961	30573-30582	GO:0000785	denotes	chromatin
T16962	30606-30613	GO:0007126	denotes	meiotic
T16963	30614-30627	GO:0001739	denotes	sex chromatin
T16964	30667-30676	GO:0000240	denotes	diplonema
T16965	30714-30723	GO:0000239	denotes	pachytene
T16966	30724-30733	CL:0000586	denotes	germ cell
T16967	30729-30739	GO:0008219	denotes	cell death
T16968	30743-30748	PR:000006549	denotes	Dmrt7
T16969	30820-30834	GO:0000803	denotes	sex chromosome
T16970	30876-30885	GO:0000239	denotes	pachytene
T16971	30886-30893	GO:0001741	denotes	XY body
T16972	30979-30992	GO:0097617	denotes	hybridization
T16973	31018-31049	GO:0006366	denotes	RNA polymerase II transcription
T16974	31065-31069	CHEBI:51231	denotes	DAPI
T16975	31093-31100	GO:0001741	denotes	XY body
T16976	31115-31135	UBERON:0001343	denotes	seminiferous tubules
T16977	31159-31164	PR:000006549	denotes	Dmrt7
T16978	31178-31185	GO:0001741	denotes	XY body
T16979	31216-31229	GO:0097617	denotes	hybridization
T16980	31259-31284	GO:0006342	denotes	transcriptional silencing
T16981	31319-31328	GO:0000239	denotes	pachytene
T16982	31353-31363	GO:0010467	denotes	expression
T16987	31460-31477	GO:0007135	denotes	secondary meiosis
T16988	31494-31498	PR:000030954	denotes	Rbmy
T16989	31527-31536	GO:0000239	denotes	pachytene
T16990	31546-31551	PR:000006549	denotes	Dmrt7
T16991	31610-31614	PR:000030954	denotes	RBMY
T16992	31615-31623	GO:0042571	denotes	antibody
T16993	31654-31669	GO:0000792	denotes	heterochromatin
T16994	31654-31684	PR:000005082	denotes	heterochromatin protein 1 beta
T16995	31686-31690	PR:000005082	denotes	HP1β
T16996	31725-31726	GO:0000805	denotes	X
T16997	31745-31754	GO:0000239	denotes	pachynema
T16998	31784-31791	GO:0001741	denotes	XY body
T16999	31818-31827	GO:0000240	denotes	diplonema
T17000	31848-31852	PR:000005082	denotes	HP1β
T17001	31879-31884	PR:000006549	denotes	DMRT7
T17002	31905-31914	GO:0000239	denotes	pachynema
T17003	31962-31969	GO:0001741	denotes	XY body
T17004	32026-32031	PR:000006549	denotes	Dmrt7
T17005	32039-32049	CL:0000586	denotes	germ cells
T17006	33375-33388	GO:0001739	denotes	sex chromatin
T17007	33456-33465	GO:0000239	denotes	pachynema
T17008	33504-33509	PR:000006549	denotes	Dmrt7
T17009	33541-33550	GO:0006915	denotes	apoptosis
T17010	33560-33569	GO:0000240	denotes	diplonema
T17011	33630-33635	PR:000006549	denotes	Dmrt7
T17012	33643-33656	CL:0000017	denotes	spermatocytes
T17013	33670-33679	GO:0000239	denotes	pachytene
T17014	33707-33716	GO:0000240	denotes	diplonema
T17015	33768-33781	GO:0097617	denotes	hybridization
T17016	33792-33807	GO:0000792	denotes	heterochromatic
T17017	33857-33868	GO:0000791	denotes	euchromatic
T17018	33922-33935	GO:0001739	denotes	sex chromatin
T17019	33964-33972	GO:0016458	denotes	silenced
T17020	34062-34069	CHEBI:15358	denotes	histone
T17021	34062-34072	PR:000027594	denotes	histone H3
T17022	34116-34118	PR:000027594	denotes	H3
T17023	34116-34124	SO:0001728	denotes	H3-2meK9
T17024	34126-34128	PR:000027594	denotes	H3
T17025	34126-34134	SO:0001707	denotes	H3-3meK9
T17026	34153-34157	PR:000005082	denotes	HP1β
T17027	34170-34177	GO:0001741	denotes	XY body
T17028	34248-34261	GO:0001739	denotes	sex chromatin
T17029	34299-34304	PR:000006549	denotes	Dmrt7
T17030	34305-34314	GO:0000240	denotes	diplotene
T17031	34331-34335	PR:000005082	denotes	HP1β
T17032	34356-34368	GO:0000805	denotes	X chromosome
T17033	34413-34422	GO:0000239	denotes	pachynema
T17034	34436-34441	PR:000006549	denotes	Dmrt7
T17035	34449-34458	GO:0000240	denotes	diplotene
T17036	34498-34502	PR:000005082	denotes	HP1β
T17037	34517-34524	GO:0001741	denotes	XY body
T17038	34565-34570	PR:000006549	denotes	Dmrt7
T17039	34578-34587	GO:0000240	denotes	diplotene
T17040	34618-34620	PR:000027594	denotes	H3
T17041	34618-34626	SO:0001728	denotes	H3-2meK9
T17042	34631-34633	PR:000027594	denotes	H3
T17043	34631-34639	SO:0001707	denotes	H3-3meK9
T17044	34655-34668	GO:0001739	denotes	sex chromatin
T17045	34693-34698	PR:000006549	denotes	Dmrt7
T17046	34706-34715	GO:0000240	denotes	diplotene
T17047	34754-34758	PR:000005082	denotes	HP1β
T17048	34766-34779	GO:0001739	denotes	sex chromatin
T17049	34834-34843	GO:0000240	denotes	diplonema
T17050	34851-34855	PR:000005082	denotes	HP1β
T17051	34863-34870	GO:0001741	denotes	XY body
T17052	34960-34964	PR:000005082	denotes	HP1β
T17053	34996-35003	GO:0007126	denotes	meiosis
T17054	35042-35051	GO:0000240	denotes	diplotene
T17055	35075-35088	GO:0001739	denotes	sex chromatin
T17056	35107-35116	GO:0030849	denotes	autosomal
T17057	35164-35177	SO:0000985	denotes	double-strand
T17058	35182-35188	MOP:0000780	denotes	breaks
T17059	35230-35239	GO:0000240	denotes	diplotene
T17060	35281-35290	GO:0006915	denotes	apoptosis
T17061	35316-35329	GO:0001739	denotes	sex chromatin
T17062	35347-35356	GO:0000240	denotes	diplonema
T17063	35525-35532	GO:0001741	denotes	XY body
T17064	35672-35680	GO:0042571	denotes	antibody
T17065	35684-35689	PR:000015865	denotes	SYCP3
T17066	35732-35737	PR:000006549	denotes	Dmrt7
T17067	35745-35754	GO:0000240	denotes	diplotene
T17068	35769-35773	PR:000005082	denotes	HP1β
T17069	35794-35801	GO:0001741	denotes	XY body
T17070	35874-35879	PR:000006549	denotes	Dmrt7
T17071	35912-35919	GO:0001741	denotes	XY body
T17072	35927-35936	GO:0000239	denotes	pachynema
T17073	35987-36000	GO:0001739	denotes	sex chromatin
T17074	35991-36011	GO:0016568	denotes	chromatin transition
T17075	36017-36026	GO:0000239	denotes	pachynema
T17076	36030-36039	GO:0000240	denotes	diplonema
T20986	39380-39393	GO:0001739	denotes	sex chromatin
T20987	39478-39487	GO:0000240	denotes	diplonema
T20988	39502-39507	PR:000006549	denotes	Dmrt7
T20989	39515-39525	CL:0000586	denotes	germ cells
T20990	39544-39553	GO:0006915	denotes	apoptosis
T20991	39591-39604	GO:0001739	denotes	sex chromatin
T20992	39641-39650	GO:0006915	denotes	apoptosis
T20993	39675-39688	GO:0001739	denotes	sex chromatin
T20994	39724-39737	GO:0001739	denotes	sex chromatin
T20995	39756-39765	GO:0006915	denotes	apoptosis
T20996	39838-39851	GO:0001739	denotes	sex chromatin
T20997	39882-39891	GO:0006915	denotes	apoptosis
T20998	39908-39917	GO:0006915	denotes	apoptosis
T20999	39931-39944	GO:0001739	denotes	sex chromatin
T21000	39984-39989	PR:000006549	denotes	Dmrt7
T21001	40092-40097	PR:000006549	denotes	DMRT7
T21002	40170-40177	GO:0001741	denotes	XY body
T21003	40189-40196	PR:000043452	denotes	histone
T21004	40189-40196	CHEBI:15358	denotes	histone
T21005	40219-40227	PR:000043452	denotes	histones
T20907	36540-36546	SO:0000417	denotes	domain
T20908	36555-36560	PR:000006549	denotes	DMRT7
T20909	36577-36592	CL:0000015	denotes	male germ cells
T20910	36605-36612	GO:0007126	denotes	meiotic
T20911	36613-36621	GO:0051324	denotes	prophase
T20912	36676-36681	PR:000006549	denotes	DMRT7
T20913	36682-36692	GO:0010467	denotes	expression
T20914	36707-36716	GO:0000239	denotes	pachytene
T20915	36717-36730	CL:0000017	denotes	spermatocytes
T20916	36780-36787	GO:0001741	denotes	XY body
T20917	36810-36820	GO:0010467	denotes	expression
T20918	36848-36863	CL:0000015	denotes	male germ cells
T20919	36874-36883	GO:0000239	denotes	pachynema
T20920	36896-36905	GO:0006915	denotes	apoptosis
T20921	36951-36960	GO:0000240	denotes	diplonema
T20922	36998-37007	GO:0000785	denotes	chromatin
T20923	37069-37078	GO:0000240	denotes	diplonema
T20924	37088-37101	GO:0001739	denotes	sex chromatin
T20925	37141-37150	GO:0000239	denotes	pachytene
T20926	37160-37168	GO:0051324	denotes	prophase
T20927	37232-37239	GO:0007129	denotes	synapse
T20928	37289-37311	GO:0051598	denotes	pachytene surveillance
T20929	37329-37336	GO:0065007	denotes	monitor
T20930	37351-37358	GO:0007126	denotes	meiotic
T20931	37450-37459	GO:0006915	denotes	apoptosis
T20932	37487-37496	GO:0000239	denotes	pachynema
T20933	37505-37512	NCBITaxon:40674	denotes	mammals
T20934	37537-37552	GO:0000803	denotes	sex chromosomes
T20935	37562-37569	GO:0001741	denotes	XY body
T20936	37616-37628	GO:0007140	denotes	male meiosis
T20937	37636-37640	NCBITaxon:10088	denotes	mice
T20938	37645-37649	NCBITaxon:10088	denotes	mice
T20939	37661-37675	GO:0000803	denotes	sex-chromosome
T20940	37679-37687	GO:0030849	denotes	autosome
T20941	37731-37745	GO:0000803	denotes	sex chromosome
T20942	37788-37797	GO:0000239	denotes	pachynema
T20943	37869-37881	GO:0065007	denotes	surveillance
T20944	37904-37913	GO:0006915	denotes	apoptosis
T20945	37917-37922	PR:000006549	denotes	Dmrt7
T20946	37930-37943	CL:0000017	denotes	spermatocytes
T20947	37998-38007	GO:0000239	denotes	pachytene
T20948	38107-38127	GO:0007129	denotes	chromosomal synapsis
T20949	38163-38168	PR:000006549	denotes	Dmrt7
T20950	38211-38218	GO:0001741	denotes	XY body
T20951	38247-38252	PR:000006549	denotes	DMRT7
T20952	38296-38303	GO:0001741	denotes	XY body
T20953	38337-38342	PR:000006549	denotes	Dmrt7
T20954	38405-38412	GO:0001741	denotes	XY body
T20955	38471-38480	GO:0000785	denotes	chromatin
T20956	38516-38529	GO:0097617	denotes	hybridization
T20957	38546-38550	PR:000030954	denotes	RBMY
T20958	38551-38561	GO:0010467	denotes	expression
T20959	38611-38618	GO:0001741	denotes	XY body
T20960	38626-38635	GO:0000239	denotes	pachytene
T20961	38636-38641	PR:000006549	denotes	Dmrt7
T20962	38711-38724	GO:0001739	denotes	sex chromatin
T20963	38728-38733	PR:000006549	denotes	Dmrt7
T20964	38741-38751	CL:0000586	denotes	germ cells
T20965	38775-38784	GO:0000239	denotes	pachynema
T20966	38808-38817	GO:0000240	denotes	diplonema
T20967	38845-38847	PR:000027594	denotes	H3
T20968	38845-38853	SO:0001728	denotes	H3-2meK9
T20969	38858-38860	PR:000027594	denotes	H3
T20970	38858-38866	SO:0001707	denotes	H3-3meK9
T20971	38877-38881	PR:000005082	denotes	HP1β
T20972	38897-38910	GO:0001739	denotes	sex chromatin
T20973	38931-38940	GO:0000240	denotes	diplonema
T20974	38965-38974	GO:0000240	denotes	diplotene
T20975	39034-39039	PR:000006549	denotes	Dmrt7
T20976	39047-39057	CL:0000586	denotes	germ cells
T20977	39076-39085	GO:0000239	denotes	pachynema
T20978	39089-39098	GO:0000240	denotes	diplonema
T20979	39121-39134	GO:0001739	denotes	sex chromatin
T20980	39125-39147	GO:0016568	denotes	chromatin modification
T20981	39190-39203	GO:0001739	denotes	sex chromatin
T20982	39236-39241	PR:000006549	denotes	DMRT7
T20983	39258-39265	GO:0007126	denotes	meiosis
T20984	39309-39316	NCBITaxon:40674	denotes	mammals
T20985	39341-39350	GO:0000240	denotes	diplotene
T21006	40219-40227	CHEBI:15358	denotes	histones
T21007	40231-40237	UBERON:0000473	denotes	testis
T21008	40247-40254	PR:000043452	denotes	histone
T21009	40247-40254	CHEBI:15358	denotes	histone
T21010	40255-40261	CHEBI:32875	denotes	methyl
T21011	40298-40304	SO:0000910	denotes	orphan
T21012	40314-40323	CL:0000586	denotes	germ-cell
T21013	40314-40338	PR:000011413	denotes	germ-cell nuclear factor
T21014	40324-40331	GO:0005634	denotes	nuclear
T21015	40436-40451	GO:0000792	denotes	heterochromatin
T21016	40487-40492	PR:000006549	denotes	DMRT7
T21017	40510-40517	GO:0001741	denotes	XY body
T21018	40630-40635	PR:000006549	denotes	DMRT7
T21019	40707-40716	GO:0000785	denotes	chromatin
T21020	40735-40742	GO:0001741	denotes	XY body
T21021	40778-40787	GO:0000785	denotes	Chromatin
T21022	40788-40798	GO:0065007	denotes	regulation
T21023	40832-40838	SO:0000417	denotes	domain
T21024	40874-40880	SO:0000417	denotes	domain
T21025	40905-40914	GO:0000785	denotes	chromatin
T21026	40905-40924	GO:0016568	denotes	chromatin modifying
T21027	40925-40934	GO:0032991	denotes	complexes
T21028	41019-41024	PR:000006549	denotes	Dmrt7
T21029	41042-41051	NCBITaxon:40674	denotes	mammalian
T21030	41052-41059	GO:0007126	denotes	meiosis
T21031	41096-41100	SO:0000704	denotes	gene
T21032	41125-41131	SO:0000417	denotes	domain
T21033	41132-41137	SO:0000704	denotes	genes
T21034	41181-41194	CL:0002371	denotes	somatic cells
T21035	41209-41215	SO:0000417	denotes	domain
T21036	41216-41221	SO:0000704	denotes	genes
T21037	41223-41228	PR:000006542	denotes	Dmrt1
T21038	41233-41238	PR:000006545	denotes	Dmrt4
T21039	41250-41259	CL:0000586	denotes	germ cell
T21040	41250-41271	GO:0007281	denotes	germ cell development
T21041	41279-41284	NCBITaxon:10088	denotes	mouse
T21042	41286-41291	PR:000006542	denotes	Dmrt1
T21043	41311-41318	GO:0007126	denotes	meiotic
T21044	41319-41334	CL:0000015	denotes	male germ cells
T21045	41339-41354	GO:0030154	denotes	differentiation
T21046	41358-41367	CL:0000670	denotes	gonocytes
T21047	41373-41386	CL:0000020	denotes	spermatogonia
T21048	41402-41415	CL:0000216	denotes	Sertoli cells
T21049	41431-41440	GO:0010467	denotes	expressed
T21050	41444-41451	GO:0007126	denotes	meiotic
T21051	41527-41532	PR:000006542	denotes	DMRT1
T21052	41540-41547	GO:0007126	denotes	meiotic
T21053	41548-41558	CL:0000586	denotes	germ cells
T21054	41563-41568	PR:000006549	denotes	DMRT7
T21055	41572-41579	GO:0007126	denotes	meiotic
T21056	41580-41590	CL:0000586	denotes	germ cells
T21057	41612-41618	SO:0000417	denotes	domain
T21058	41663-41677	CL:0000015	denotes	male germ cell
T21059	41668-41689	GO:0007281	denotes	germ cell development
T21060	41691-41698	UBERON:0000992	denotes	Ovaries
T21061	41702-41707	PR:000006545	denotes	Dmrt4
T21062	41732-41738	CL:0000025	denotes	ovular
T21063	41780-41787	CL:0000023	denotes	oocytes
T21064	41903-41912	NCBITaxon:40674	denotes	mammalian
T21065	41916-41922	SO:0000417	denotes	domain
T21066	41923-41928	SO:0000704	denotes	genes
T21067	41936-41943	UBERON:0000991	denotes	gonadal
T21068	41936-41955	GO:0008406	denotes	gonadal development
T21069	42030-42062	GO:0007546	denotes	sex-specific somatic development
T21070	42072-42077	NCBITaxon:phylum	denotes	phyla
T21071	42091-42096	PR:000006549	denotes	Dmrt7
T21072	42121-42130	UBERON:0001987	denotes	placental
T21073	42121-42138	NCBITaxon:9347	denotes	placental mammals
T21074	42152-42162	NCBITaxon:9263	denotes	marsupials
T21075	42169-42178	NCBITaxon:9255	denotes	monotreme
T21076	42180-42183	UBERON:0007379	denotes	egg
T21077	42180-42197	NCBITaxon:9255	denotes	egg-laying mammal
T21078	42204-42212	NCBITaxon:9258	denotes	platypus
T21079	42232-42237	PR:000006549	denotes	Dmrt7
T21080	42238-42246	SO:0000855	denotes	ortholog
T21081	42271-42276	PR:000006549	denotes	Dmrt7
T21082	42277-42285	SO:0000855	denotes	ortholog
T21083	42310-42319	NCBITaxon:40674	denotes	mammalian
T21084	42320-42331	NCBITaxon:7742	denotes	vertebrates
T21085	42385-42390	PR:000006549	denotes	Dmrt7
T21086	42462-42466	SO:0000704	denotes	gene
T21087	42506-42515	NCBITaxon:40674	denotes	mammalian
T21088	42527-42537	NCBITaxon:9255	denotes	Monotremes
T21089	42548-42549	_FRAGMENT	denotes	X
T21090	42561-42572	GO:0000805	denotes	chromosomes
T21091	42559-42572	GO:0000806	denotes	Y chromosomes
T21092	42618-42625	GO:0007126	denotes	meiosis
T21093	42654-42669	GO:0000803	denotes	sex chromosomes
T21094	42683-42690	NCBITaxon:40674	denotes	mammals
T21095	42713-42718	PR:000006549	denotes	Dmrt7
T21096	42779-42794	GO:0000803	denotes	sex chromosomes
T21097	42802-42815	GO:0001739	denotes	sex chromatin
T21098	42819-42829	NCBITaxon:9255	denotes	monotremes
T21099	42840-42847	NCBITaxon:40674	denotes	mammals
T21100	42875-42880	PR:000006549	denotes	Dmrt7
T21101	42917-42926	NCBITaxon:40674	denotes	mammalian
T21102	42927-42944	GO:0007530	denotes	sex determination
T21103	42988-42992	SO:0000704	denotes	gene
T21104	43001-43019	GO:0007129	denotes	chromosome pairing
T21105	43045-43052	GO:0007126	denotes	meiotic
T21106	43073-43087	GO:0000803	denotes	sex chromosome
T21107	43155-43160	PR:000006549	denotes	Dmrt7
T21108	43168-43177	NCBITaxon:40674	denotes	mammalian
T21109	43227-43236	GO:0000785	denotes	chromatin
T21110	43237-43247	GO:0065007	denotes	regulatory
T21111	43248-43257	GO:0032991	denotes	complexes
T21112	43277-43296	GO:0007549	denotes	dosage compensation
T21113	43331-43346	GO:0000803	denotes	sex chromosomes
T21114	43358-43363	NCBITaxon:phylum	denotes	phyla
T21115	43428-43433	PR:000006549	denotes	DMRT7
T21116	43447-43462	GO:0000803	denotes	sex chromosomes
T21117	43470-43479	NCBITaxon:9255	denotes	monotreme
T21118	43480-43487	GO:0007126	denotes	meiosis
T21119	43524-43530	NCBITaxon:40674	denotes	mammal
T21120	43543-43549	SO:0000417	denotes	domain
T21121	43558-43563	PR:000006549	denotes	DMRT7
T21122	43581-43588	GO:0007126	denotes	meiotic
T21123	43589-43597	GO:0051324	denotes	prophase
T21124	43620-43625	PR:000006549	denotes	DMRT7
T21125	43643-43658	GO:0000803	denotes	sex chromosomes
T21126	43701-43716	GO:0000792	denotes	heterochromatin
T21127	43727-43732	PR:000006549	denotes	Dmrt7
T21128	43777-43792	_FRAGMENT	denotes	modification of
T21129	43801-43810	GO:0016568	denotes	chromatin
T21130	43797-43810	GO:0001739	denotes	sex chromatin
T21131	43819-43828	GO:0000239	denotes	pachytene
T21132	43833-43842	GO:0000240	denotes	diplotene
T21133	43853-43858	PR:000006549	denotes	Dmrt7
T21134	43895-43899	SO:0000704	denotes	gene
T21135	43928-43935	NCBITaxon:40674	denotes	mammals
T21136	43958-43963	PR:000006549	denotes	DMRT7
T21137	43989-43995	NCBITaxon:40674	denotes	mammal
T21138	44035-44042	GO:0007126	denotes	meiosis
T21139	44109-44114	PR:000006549	denotes	DMRT7
T21140	44123-44136	GO:0001739	denotes	sex chromatin
T21141	44137-44147	GO:0065007	denotes	regulation
T21142	44155-44167	GO:0007140	denotes	male meiosis
T23630	44207-44212	PR:000006549	denotes	Dmrt7
T23631	44213-44217	NCBITaxon:10088	denotes	mice
T23632	44221-44226	NCBITaxon:10088	denotes	mouse
T23633	44227-44232	PR:000006549	denotes	Dmrt7
T23634	44273-44277	SO:0000147	denotes	exon
T23635	44301-44306	NCBITaxon:10088	denotes	mouse
T23636	44307-44310	SO:0000153	denotes	BAC
T23637	44406-44414	SO:0000167	denotes	promoter
T23638	44463-44468	PR:000006549	denotes	Dmrt7
T23639	44469-44476	SO:0001026	denotes	genomic
T23640	44491-44507	SO:0001644	denotes	targeting vector
T23641	44586-44592	SO:0000440	denotes	vector
T23642	44623-44629	SO:0000440	denotes	vector
T23643	44658-44667	SO:0000346	denotes	loxP site
T23644	44721-44727	SO:0000188	denotes	intron
T23645	44731-44736	PR:000006549	denotes	Dmrt7
T23646	44747-44749	SO:0000028	denotes	bp
T23647	44759-44761	SO:0000028	denotes	bp
T23648	44776-44780	SO:0000147	denotes	exon
T23649	44877-44879	SO:0000028	denotes	bp
T23650	44887-44889	SO:0000028	denotes	bp
T23651	44900-44905	PR:000006549	denotes	Dmrt7
T23652	44906-44919	GO:0006412	denotes	translational
T23653	44950-44959	SO:0000346	denotes	loxP site
T23654	44969-44973	SO:0000061	denotes	site
T23655	44978-44980	SO:0000028	denotes	bp
T23656	44991-44996	PR:000006549	denotes	Dmrt7
T23657	44997-45010	GO:0006412	denotes	translational
T23658	45035-45041	SO:0000440	denotes	vector
T23659	45064-45069	SO:0000147	denotes	exons
T23660	45073-45078	PR:000006549	denotes	Dmrt7
T23661	45083-45090	SO:0000357	denotes	flanked
T23662	45094-45104	SO:0000346	denotes	loxP sites
T23663	45106-45112	SO:0000359	denotes	floxed
T23664	45119-45124	PR:000006549	denotes	Dmrt7
T23665	45242-45250	CL:0002322	denotes	ES cells
T23666	45350-45354	CHEBI:42768	denotes	G418
T23667	45386-45399	GO:0097617	denotes	hybridization
T23668	45453-45457	SO:0000147	denotes	exon
T23669	45470-45477	SO:0001026	denotes	genomic
T23670	45590-45603	GO:0097617	denotes	hybridization
T23671	45625-45638	GO:0097617	denotes	hybridization
T23672	45662-45669	SO:0000112	denotes	primers
T23673	45752-45759	CL:0002322	denotes	ES cell
T23674	45782-45788	SO:0000359	denotes	floxed
T23675	45789-45795	SO:0001023	denotes	allele
T23676	45796-45801	PR:000006549	denotes	Dmrt7
T23677	45832-45843	UBERON:0000358	denotes	blastocysts
T23678	45947-45952	PR:000006549	denotes	Dmrt7
T23679	45957-45962	PR:000006549	denotes	Dmrt7
T23680	45964-45969	PR:000006549	denotes	Dmrt7
T23681	46001-46008	PR:000003676	denotes	β-actin
T23682	46024-46028	NCBITaxon:10088	denotes	mice
T23683	46043-46049	SO:0000359	denotes	floxed
T23684	46086-46091	PR:000006549	denotes	Dmrt7
T23685	46158-46163	PR:000006549	denotes	Dmrt7
T24437	46216-46220	UBERON:0002415	denotes	tail
T24438	46302-46309	SO:0000112	denotes	primers
T24439	46317-46329	GO:0000806	denotes	Y chromosome
T24440	46330-46334	SO:0000704	denotes	gene
T24441	46335-46338	PR:000017657	denotes	Zfy
T24442	46362-46367	PR:000006549	denotes	Dmrt7
T24443	46368-46374	SO:0001023	denotes	allele
T24444	46375-46380	PR:000006549	denotes	Dmrt7
T24445	46428-46437	GO:0097617	denotes	annealing
T24446	46464-46469	PR:000006549	denotes	Dmrt7
T24447	46469-46473	SO:0000359	denotes	flox
T24448	46474-46480	SO:0001023	denotes	allele
T24449	46529-46538	GO:0097617	denotes	annealing
T24450	46573-46578	PR:000006549	denotes	Dmrt7
T24451	46579-46585	SO:0001023	denotes	allele
T24452	46586-46591	PR:000006549	denotes	Dmrt7
T24453	46633-46642	GO:0097617	denotes	annealing
T24454	46676-46681	PR:000006549	denotes	Dmrt7
T24455	46682-46692	GO:0010467	denotes	expression
T24456	46730-46737	SO:0000112	denotes	primers
T24457	46758-46767	GO:0097617	denotes	annealing
T24838	46791-46798	SO:0000112	denotes	Primers
T25199	47426-47432	UBERON:0000473	denotes	testes
T25200	47455-47463	CHEBI:50913	denotes	fixative
T25201	47486-47494	CHEBI:16842	denotes	formalin
T25202	47551-47558	CHEBI:16236	denotes	ethanol
T25203	47592-47595	CHEBI:73702	denotes	wax
T25204	47663-47674	CHEBI:51686	denotes	hematoxylin
T25205	47793-47810	CHEBI:16240	denotes	hydrogen peroxide
T25206	47863-47870	GO:0005634	denotes	nuclear
T25207	47883-47898	CL:0000445	denotes	apoptotic cells
T25480	48013-48019	UBERON:0000479	denotes	Tissue
T25481	48103-48111	CHEBI:53424	denotes	Tween 20
T25482	48144-48155	CHEBI:30769	denotes	citric acid
T25483	48217-48222	UBERON:0001977	denotes	serum
T25484	48264-48272	GO:0042571	denotes	antibody
T25485	48336-48346	GO:0042571	denotes	antibodies
T25486	48399-48409	GO:0042571	denotes	antibodies
T26386	49924-49928	NCBITaxon:9925	denotes	goat
T26387	49934-49940	NCBITaxon:9986	denotes	rabbit
T26388	49941-49950	CHEBI:52661	denotes	Alexa 488
T26389	49952-49956	NCBITaxon:9925	denotes	goat
T26390	49962-49968	NCBITaxon:9986	denotes	rabbit
T26338	48412-48422	GO:0042571	denotes	Antibodies
T26339	48424-48430	NCBITaxon:9986	denotes	Rabbit
T26340	48442-48452	GO:0042571	denotes	antibodies
T26341	48456-48461	PR:000006549	denotes	DMRT7
T26342	48519-48530	CHEBI:16856	denotes	glutathione
T26343	48564-48565	CHEBI:18245	denotes	C
T26344	48594-48599	PR:000006549	denotes	DMRT7
T26345	48601-48611	GO:0042571	denotes	Antibodies
T26346	48677-48682	UBERON:0001977	denotes	serum
T26347	48708-48713	PR:000006549	denotes	DMRT7
T26348	48741-48746	PR:000006549	denotes	DMRT7
T26349	48747-48755	GO:0042571	denotes	antibody
T26350	48790-48794	NCBITaxon:9925	denotes	goat
T26351	48800-48806	NCBITaxon:9986	denotes	rabbit
T26352	48817-48825	GO:0042571	denotes	antibody
T26353	48905-48915	GO:0042571	denotes	antibodies
T26354	48949-48952	NCBITaxon:10114	denotes	rat
T26355	48958-48963	PR:000007857	denotes	GATA1
T26356	49028-49032	NCBITaxon:9925	denotes	goat
T26357	49038-49043	PR:000007859	denotes	GATA4
T26358	49088-49091	NCBITaxon:10114	denotes	rat
T26359	49148-49151	NCBITaxon:10114	denotes	rat
T26360	49205-49208	NCBITaxon:10114	denotes	rat
T26361	49266-49272	NCBITaxon:9986	denotes	rabbit
T26362	49278-49283	PR:000013672	denotes	RAD51
T26363	49338-49343	NCBITaxon:10088	denotes	mouse
T26364	49349-49354	PR:000015829	denotes	GMP-1
T26365	49355-49361	PR:000015829	denotes	SUMO-1
T26366	49410-49416	NCBITaxon:9986	denotes	rabbit
T26367	49422-49429	CHEBI:32958	denotes	phospho
T26368	49430-49434	PR:000008418	denotes	H2AX
T26369	49496-49501	NCBITaxon:10088	denotes	mouse
T26370	49507-49514	CHEBI:32958	denotes	phospho
T26371	49515-49519	PR:000008418	denotes	H2AX
T26372	49546-49551	NCBITaxon:10088	denotes	mouse
T26373	49557-49562	PR:000015865	denotes	SYCP3
T26374	49610-49616	NCBITaxon:9986	denotes	rabbit
T26375	49622-49626	PR:000005082	denotes	HP1β
T26376	49652-49658	NCBITaxon:9986	denotes	rabbit
T26377	49664-49666	PR:000027594	denotes	H3
T26378	49664-49672	SO:0001728	denotes	H3-2meK9
T26379	49699-49705	NCBITaxon:9986	denotes	rabbit
T26380	49711-49713	PR:000027594	denotes	H3
T26381	49711-49719	SO:0001707	denotes	H3-3meK9
T26382	49746-49752	NCBITaxon:9986	denotes	rabbit
T26383	49815-49820	NCBITaxon:10088	denotes	mouse
T26384	49826-49830	PR:000003675	denotes	αSMA
T26385	49903-49913	GO:0042571	denotes	antibodies
T26391	49969-49978	CHEBI:51248	denotes	Alexa 594
T26392	49980-49984	NCBITaxon:9925	denotes	goat
T26393	49990-49993	NCBITaxon:10114	denotes	rat
T26394	49994-50003	CHEBI:51248	denotes	Alexa 594
T26395	50009-50013	NCBITaxon:9925	denotes	goat
T26396	50019-50024	NCBITaxon:10088	denotes	mouse
T26397	50025-50034	CHEBI:52661	denotes	Alexa 488
T26398	50069-50075	NCBITaxon:9793	denotes	Donkey
T26399	50081-50085	NCBITaxon:9925	denotes	goat
T26400	50086-50090	CHEBI:37926	denotes	FITC
T26401	50163-50169	NCBITaxon:9793	denotes	donkey
T26402	50175-50181	NCBITaxon:9986	denotes	rabbit
T26403	50182-50191	CHEBI:51247	denotes	Texas Red
T27158	50267-50274	GO:0007126	denotes	Meiotic
T27159	50316-50323	GO:0007126	denotes	Meiotic
T27160	50379-50383	NCBITaxon:10088	denotes	mice
T27161	50474-50481	GO:0007126	denotes	meiotic
T27162	50573-50580	GO:0007126	denotes	meiotic
T27163	50581-50594	CL:0000017	denotes	spermatocytes
T27681	10545-10555	GO:0010467	denotes	Expression
T27682	10559-10564	PR:000006549	denotes	Dmrt7
T27683	10605-10610	PR:000006549	denotes	Dmrt7
T27684	10625-10631	UBERON:0000062	denotes	organs
T27685	10635-10640	UBERON:0007023	denotes	adult
T27686	10641-10646	NCBITaxon:10088	denotes	mouse
T27687	10663-10668	UBERON:0000062	denotes	organ
T27688	10688-10695	SO:0000112	denotes	primers
T27689	10709-10714	PR:000006549	denotes	Dmrt7
T27690	10729-10736	PR:000003676	denotes	β-actin
T27691	10755-10760	PR:000006549	denotes	Dmrt7
T27692	10766-10776	GO:0010467	denotes	expression
T27693	10803-10818	GO:0007283	denotes	spermatogenesis
T27694	10840-10846	UBERON:0000473	denotes	testis
T27695	10875-10880	GO:0007567	denotes	birth
T27696	10911-10916	PR:000006549	denotes	DMRT7
T27697	10925-10935	GO:0010467	denotes	expression
T27698	10959-10965	UBERON:0000473	denotes	testis
T27699	11007-11015	GO:0042571	denotes	antibody
T27700	11019-11024	PR:000006549	denotes	DMRT7
T27701	11037-11041	CHEBI:51231	denotes	DAPI
T27702	11054-11059	PR:000006549	denotes	DMRT7
T27703	11088-11095	GO:0001741	denotes	XY body
T27704	11097-11103	UBERON:0000473	denotes	Testis
T27705	11145-11155	GO:0042571	denotes	antibodies
T27706	11159-11164	PR:000006549	denotes	DMRT7
T27707	11175-11181	PR:000015829	denotes	SUMO-1
T27708	11191-11197	PR:000015829	denotes	SUMO-1
T27709	11218-11225	GO:0001741	denotes	XY body
T27710	11314-11323	GO:0000239	denotes	pachytene
T27711	11324-11337	CL:0000017	denotes	spermatocytes
T27712	11343-11352	GO:0001741	denotes	XY bodies
T28401	17313-17319	UBERON:0000473	denotes	Testis
T28402	17329-17338	CL:0000586	denotes	Germ Cell
T28403	17334-17348	GO:0006915	denotes	Cell Apoptosis
T28404	17352-17356	NCBITaxon:10088	denotes	Mice
T28405	17383-17388	PR:000006549	denotes	Dmrt7
T28406	17393-17399	UBERON:0000473	denotes	Testes
T28407	17432-17437	NCBITaxon:10088	denotes	mouse
T28408	17461-17466	PR:000006549	denotes	Dmrt7
T28409	17504-17510	UBERON:0000473	denotes	testes
T28410	17557-17561	NCBITaxon:10088	denotes	mice
T28411	17579-17590	CHEBI:51686	denotes	hematoxylin
T28412	17719-17726	UBERON:0000025	denotes	tubules
T28413	17748-17761	CL:0000017	denotes	spermatocytes
T28414	17865-17872	UBERON:0000025	denotes	tubules
T28415	17881-17900	CL:0000228	denotes	multinucleate cells
T28416	17886-17894	GO:0005634	denotes	nucleate
T28417	17952-17957	PR:000006549	denotes	Dmrt7
T28418	17968-17973	NCBITaxon:10088	denotes	mouse
T28419	17974-17980	UBERON:0000473	denotes	testes
T28420	17982-17988	UBERON:0000473	denotes	Testes
T28421	18080-18095	CL:0000445	denotes	apoptotic cells
T28422	18097-18103	UBERON:0000473	denotes	Testis
T28423	18144-18148	NCBITaxon:10088	denotes	mice
T28424	18154-18169	CL:0000445	denotes	Apoptotic cells
T28425	18204-18224	UBERON:0001343	denotes	seminiferous tubules
T28426	18239-18244	PR:000006549	denotes	Dmrt7
T28427	18252-18256	NCBITaxon:10088	denotes	mice
T28940	20879-20889	GO:0007128	denotes	Prophase I
T28941	20900-20905	PR:000006549	denotes	Dmrt7
T28942	20913-20923	CL:0000586	denotes	Germ Cells
T28943	20924-20930	UBERON:0000473	denotes	Testis
T28944	20974-20979	PR:000006549	denotes	Dmrt7
T28945	21033-21043	GO:0042571	denotes	antibodies
T28946	21056-21069	GO:0007283	denotes	spermatogenic
T28947	21087-21095	GO:0042571	denotes	antibody
T28948	21112-21125	CL:0000020	denotes	spermatogonia
T28949	21178-21186	GO:0042571	denotes	antibody
T28950	21194-21207	CL:0000017	denotes	spermatocytes
T28951	21263-21271	GO:0042571	denotes	antibody
T28952	21279-21288	GO:0000239	denotes	pachytene
T28953	21299-21309	CL:0000586	denotes	germ cells
T28954	21354-21360	UBERON:0000473	denotes	testis
T29218	21383-21390	GO:0007126	denotes	Meiotic
T29219	21401-21406	PR:000006549	denotes	Dmrt7
T29220	21414-21420	UBERON:0000473	denotes	Testis
T29221	21446-21463	_FRAGMENT	denotes	meiotic stages of
T29222	21469-21474	GO:0098762	denotes	cells
T29223	21464-21474	CL:0000586	denotes	germ cells
T29224	21543-21549	UBERON:0000473	denotes	testes
T29225	21578-21598	GO:0000795	denotes	synaptonemal complex
T29226	21607-21612	PR:000015865	denotes	SYCP3
T29562	23000-23008	GO:0007129	denotes	Synapsis
T29563	23030-23035	PR:000006549	denotes	Dmrt7
T29564	23043-23053	CL:0000586	denotes	Germ Cells
T29565	23058-23068	UBERON:0000473	denotes	Testicular
T29566	23080-23085	PR:000006549	denotes	Dmrt7
T29567	23132-23136	NCBITaxon:10088	denotes	mice
T29568	23166-23174	GO:0042571	denotes	antibody
T29569	23178-23183	PR:000015865	denotes	SYCP3
T29570	23219-23226	GO:0007126	denotes	meiotic
T29571	23227-23235	GO:0051324	denotes	prophase
T29572	23245-23250	PR:000015865	denotes	SYCP3
T29573	23296-23305	GO:0000239	denotes	pachynema
T29574	23311-23320	GO:0030849	denotes	autosomes
T29575	23331-23339	GO:0007129	denotes	synapsed
T29576	23364-23372	GO:0007129	denotes	synapsed
T29577	23448-23458	UBERON:0000473	denotes	Testicular
T29578	23468-23476	GO:0000238	denotes	zygonema
T29579	23481-23490	GO:0000239	denotes	pachynema
T29580	23515-23525	GO:0042571	denotes	antibodies
T29581	23529-23534	PR:000013672	denotes	RAD51
T29582	23547-23552	PR:000015865	denotes	SYCP3
T29583	23585-23590	PR:000013672	denotes	RAD51
T29584	23637-23650	CL:0000017	denotes	spermatocytes
T30188	24817-24829	CL:0000216	denotes	Sertoli Cell
T30189	24846-24851	PR:000006549	denotes	Dmrt7
T30190	24859-24865	UBERON:0000473	denotes	Testes
T30191	24870-24876	UBERON:0000473	denotes	Testes
T30192	24900-24905	PR:000006549	denotes	Dmrt7
T30193	24913-24917	NCBITaxon:10088	denotes	mice
T30194	24950-24958	GO:0042571	denotes	antibody
T30195	24962-24967	PR:000007859	denotes	GATA4
T30196	24977-24983	UBERON:0000473	denotes	testis
T30197	25006-25014	GO:0042571	denotes	antibody
T30198	25018-25023	PR:000007857	denotes	GATA1
T30199	25033-25038	PR:000007859	denotes	GATA4
T30200	25043-25048	PR:000007857	denotes	GATA1
T30201	25092-25104	CL:0000216	denotes	Sertoli cell
T30202	25131-25137	UBERON:0000473	denotes	testis
T30203	25167-25175	GO:0042571	denotes	antibody
T30204	25179-25184	PR:000007857	denotes	GATA1
T30205	25195-25199	CHEBI:51231	denotes	DAPI
T30206	25213-25225	CL:0000216	denotes	Sertoli cell
T30207	25221-25232	GO:0005634	denotes	cell nuclei
T30208	25294-25307	CL:0000216	denotes	Sertoli cells
T30209	25331-25338	UBERON:0000025	denotes	tubules
T30210	25413-25419	UBERON:0000473	denotes	Testis
T30211	25458-25470	CL:0000216	denotes	Sertoli cell
T30212	25480-25485	PR:000006549	denotes	Dmrt7
T30213	25494-25496	CL:0000216	denotes	SC
T30214	25506-25510	NCBITaxon:10088	denotes	mice
T30215	25524-25535	CHEBI:51686	denotes	hematoxylin
T30216	25547-25562	GO:0007283	denotes	Spermatogenesis
T30217	25567-25581	GO:0007286	denotes	spermiogenesis
T30218	25596-25598	CL:0000216	denotes	SC
T30219	25607-25613	UBERON:0000473	denotes	testis
T30220	25619-25625	UBERON:0000473	denotes	Testis
T30221	25664-25666	CL:0000216	denotes	SC
T30222	25675-25679	NCBITaxon:10088	denotes	mice
T30223	25693-25703	GO:0042571	denotes	antibodies
T30224	25707-25712	PR:000007857	denotes	GATA1
T30225	25723-25736	UBERON:0001135	denotes	smooth muscle
T30226	25723-25742	PR:000003675	denotes	smooth muscle actin
T30227	25755-25775	UBERON:0001343	denotes	seminiferous tubules
T30228	25785-25797	CL:0000216	denotes	Sertoli cell
T30229	25793-25804	GO:0005634	denotes	cell nuclei
T30230	25856-25858	CL:0000216	denotes	SC
T30231	25867-25871	NCBITaxon:10088	denotes	mice
T30755	29611-29618	GO:0001741	denotes	XY Body
T30756	29641-29650	GO:0000239	denotes	Pachynema
T30757	29654-29659	PR:000006549	denotes	Dmrt7
T30758	29667-29671	NCBITaxon:10088	denotes	Mice
T30759	29676-29686	UBERON:0000473	denotes	Testicular
T30760	29717-29727	GO:0042571	denotes	antibodies
T30761	29747-29752	PR:000015865	denotes	SYCP3
T30762	29765-29774	GO:0000239	denotes	pachytene
T30763	29811-29818	GO:0001741	denotes	XY body
T30764	29841-29846	PR:000006549	denotes	Dmrt7
T30765	29859-29865	UBERON:0000473	denotes	Testes
T30766	29880-29884	NCBITaxon:10088	denotes	mice
T30767	29912-29920	GO:0042571	denotes	antibody
T30768	29941-29947	UBERON:0000473	denotes	Testes
T30769	29962-29966	NCBITaxon:10088	denotes	mice
T30770	29994-30002	GO:0042571	denotes	antibody
T30771	30006-30012	PR:000015829	denotes	SUMO-1
T30772	30031-30040	GO:0000239	denotes	pachytene
T30773	30052-30061	GO:0001741	denotes	XY bodies
T30774	30098-30104	UBERON:0000473	denotes	testes
T31497	32216-32223	GO:0001741	denotes	XY body
T31498	32275-32287	_FRAGMENT	denotes	silencing of
T31499	32303-32316	GO:0006342	denotes	transcription
T31490	32061-32070	GO:0000785	denotes	Chromatin
T31491	32088-32093	PR:000006549	denotes	Dmrt7
T31492	32101-32110	GO:0000240	denotes	Diplotene
T31493	32111-32121	CL:0000586	denotes	Germ Cells
T31494	32160-32169	GO:0000239	denotes	pachytene
T31495	32170-32182	CL:0000017	denotes	spermatocyte
T31496	32186-32191	PR:000006549	denotes	Dmrt7
T31500	32288-32302	GO:0000803	denotes	sex chromosome
T31501	32320-32327	GO:0001741	denotes	XY body
T31502	32367-32376	GO:0000239	denotes	pachynema
T31503	32417-32421	PR:000005082	denotes	HP1β
T31504	32442-32451	GO:0000239	denotes	pachytene
T31505	32452-32465	CL:0000017	denotes	spermatocytes
T31506	32467-32471	PR:000005082	denotes	HP1β
T31507	32485-32497	GO:0000805	denotes	X chromosome
T31508	32570-32583	GO:0097617	denotes	hybridization
T31509	32587-32596	GO:0000240	denotes	diplotene
T31510	32610-32617	GO:0001741	denotes	XY body
T31511	32628-32632	CHEBI:51231	denotes	DAPI
T31512	32697-32701	PR:000005082	denotes	HP1β
T31513	32705-32714	GO:0000240	denotes	diplotene
T31514	32739-32743	PR:000005082	denotes	HP1β
T31515	32755-32762	GO:0001741	denotes	XY body
T31516	32813-32825	GO:0000805	denotes	X chromosome
T31517	32860-32862	PR:000027594	denotes	H3
T31518	32860-32868	SO:0001728	denotes	H3-2meK9
T31519	32885-32894	GO:0000240	denotes	diplotene
T31520	32965-32972	GO:0001741	denotes	XY body
T31521	33006-33008	PR:000027594	denotes	H3
T31522	33006-33014	SO:0001707	denotes	H3-3meK9
T31523	33031-33040	GO:0000240	denotes	diplotene
T31524	33104-33111	GO:0001741	denotes	XY body
T31525	33132-33141	GO:0030849	denotes	autosomes
T31526	33187-33196	GO:0006915	denotes	apoptosis
T31527	33220-33229	GO:0000240	denotes	diplotene
T31528	33247-33251	PR:000005082	denotes	HP1β
T31529	33272-33279	GO:0001741	denotes	XY body
T32061	36060-36073	GO:0001739	denotes	Sex Chromatin
T32062	36093-36111	GO:0007129	denotes	Chromosome Pairing
T32063	36143-36152	CL:0000586	denotes	germ cell
T32064	36166-36170	CHEBI:51231	denotes	DAPI
T32065	36177-36182	PR:000015865	denotes	SYCP3
T32066	36193-36197	PR:000005082	denotes	HP1β
T32067	36239-36248	GO:0000240	denotes	diplonema
T32068	36266-36273	GO:0001741	denotes	XY body
T32069	36279-36283	PR:000005082	denotes	HP1β
T32070	36312-36317	PR:000006549	denotes	Dmrt7
T32071	36325-36334	CL:0000586	denotes	germ cell
T32072	36350-36359	GO:0000240	denotes	diplotene
T32073	36399-36406	GO:0001741	denotes	XY body
T32074	36415-36419	PR:000005082	denotes	HP1β
T32075	36440-36447	GO:0001741	denotes	XY body
R8199	T29222	T29221	_lexicallyChainedTo	cells,meiotic stages of
R8701	T31499	T31498	_lexicallyChainedTo	transcription,silencing of
R3	T660	T659	_lexicallyChainedTo	heterochromatin domain,formation of
R6	T690	T689	_lexicallyChainedTo	methylation,histone H3K9 di-
R7	T692	T691	_lexicallyChainedTo	trimethylation,histone H3K9
R306	T3552	T3551	_lexicallyChainedTo	chromosome,X
R307	T3556	T3555	_lexicallyChainedTo	mammals,eutherian
R308	T3681	T3680	_lexicallyChainedTo	germ cells,male
R2063	T8011	T8010	_lexicallyChainedTo	cells,embryonic stem
R2064	T8011	T8012	_lexicallyChainedTo	cells,ES
R2377	T9512	T9511	_lexicallyChainedTo	Gametogenesis,Male
R2378	T9542	T9541	_lexicallyChainedTo	cells,stages of
R2379	T9562	T9561	_lexicallyChainedTo	nuclei,cells with
R3373	T12913	T12912	_lexicallyChainedTo	cells,nuclei of
R3793	T14498	T14497	_lexicallyChainedTo	chromosomes,Condensation of
R3794	T14500	T14499	_lexicallyChainedTo	chromosomes,X
R3795	T14533	T14532	_lexicallyChainedTo	chromosomes,X
R5079	T21090	T21089	_lexicallyChainedTo	chromosomes,X
R5080	T21129	T21128	_lexicallyChainedTo	chromatin,modification of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T27177	50787-50790	CHEBI_SO_EXT:DNA	denotes	DNA
T17173	33643-33656	CL:0000017	denotes	spermatocytes
T717	2-8	NCBITaxon:40674	denotes	Mammal
T718	18-27	PR_EXT:P23023	denotes	Doublesex
T719	28-35	SO_EXT:0000853	denotes	Homolog
T720	52-56	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Male
T721	57-70	GO:0001739	denotes	Sex Chromatin
T722	91-95	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Male
T723	91-103	GO:0007140	denotes	Male Meiosis
T724	150-163	GO:0007276	denotes	Gametogenesis
T725	230-239	CL:0000586	denotes	germ cell
T726	235-239	CL_GO_EXT:cell	denotes	cell
T727	235-255	GO:0030154	denotes	cell differentiation
T728	278-285	NCBITaxon:40674	denotes	mammals
T729	317-332	GO:0000803	denotes	sex chromosomes
T730	321-332	GO_SO_EXT:chromosome	denotes	chromosomes
T731	336-341	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T732	407-408	GO:0000805	denotes	X
T733	413-414	GO:0000806	denotes	Y
T734	430-437	GO:0007126	denotes	meiotic
T735	438-446	GO:0051324	denotes	prophase
T736	462-474	_FRAGMENT	denotes	formation of
T737	477-499	GO:0031507	denotes	heterochromatin domain
T738	477-492	GO:0000792	denotes	heterochromatin
T739	505-512	GO:0001741	denotes	XY body
T740	518-525	GO:0001741	denotes	XY body
T741	545-553	GO:0051324	denotes	prophase
T742	571-584	GO:0001739	denotes	sex chromatin
T743	608-620	SO_EXT:sequence_alteration_entity_or_process	denotes	modification
T744	630-637	GO:0007126	denotes	meiosis
T745	676-681	PR_EXT:000006549	denotes	DMRT7
T746	685-691	NCBITaxon:40674	denotes	mammal
T747	701-708	CHEBI_PR_EXT:protein	denotes	protein
T748	724-736	NCBITaxon_EXT:invertebrate	denotes	invertebrate
T749	744-754	GO_EXT:regulator	denotes	regulators
T750	755-764	PR_EXT:P23023	denotes	Doublesex
T751	769-774	PR_EXT:O18214	denotes	MAB-3
T752	789-794	PR_EXT:000006549	denotes	DMRT7
T753	810-819	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T754	827-834	GO:0001741	denotes	XY body
T755	842-851	GO:0000239	denotes	pachytene
T756	861-868	GO:0007126	denotes	meiotic
T757	869-877	GO:0051324	denotes	prophase
T758	898-902	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T759	898-910	GO:0007140	denotes	male meiosis
T760	915-920	PR_EXT:000006549	denotes	Dmrt7
T761	921-928	SO_EXT:sequence_altered_entity	denotes	mutants
T762	930-945	GO:0007129	denotes	meiotic pairing
T763	950-963	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T764	985-1011	GO:0006342	denotes	transcriptionally silenced
T765	1012-1019	GO:0001741	denotes	XY body
T766	1037-1046	GO:0000785	denotes	chromatin
T767	1047-1052	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marks
T768	1073-1083	CL:0000586	denotes	germ cells
T769	1078-1083	CL_GO_EXT:cell	denotes	cells
T770	1092-1101	GO:0006915	denotes	apoptosis
T771	1109-1118	GO:0000239	denotes	pachynema
T772	1134-1140	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T773	1141-1146	CL_GO_EXT:cell	denotes	cells
T774	1163-1172	GO:0000240	denotes	diplonema
T775	1201-1206	CL_GO_EXT:cell	denotes	cells
T776	1221-1234	GO:0001739	denotes	sex chromatin
T777	1243-1250	PR_EXT:000043452	denotes	histone
T778	1243-1250	CHEBI:15358	denotes	histone
T779	1243-1259	_FRAGMENT	denotes	histone H3K9 di-
T780	1267-1278	GO:0036123	denotes	methylation
T781	1243-1255	_FRAGMENT	denotes	histone H3K9
T782	1264-1278	GO:0036124	denotes	trimethylation
T783	1267-1278	GO_MOP_EXT:methylation	denotes	methylation
T784	1283-1298	GO:0000792	denotes	heterochromatin
T785	1283-1309	PR_EXT:000005082	denotes	heterochromatin protein 1β
T786	1299-1306	CHEBI_PR_EXT:protein	denotes	protein
T787	1324-1337	SO_EXT:sequence_alteration_entity_or_process	denotes	modifications
T788	1366-1375	GO:0000239	denotes	pachynema
T789	1380-1389	GO:0000240	denotes	diplonema
T790	1404-1416	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T791	1420-1425	PR_EXT:000006549	denotes	DMRT7
T792	1433-1440	GO:0001741	denotes	XY body
T793	1449-1462	GO:0001739	denotes	sex chromatin
T794	1483-1488	PR_EXT:000006549	denotes	Dmrt7
T795	1489-1496	SO_EXT:sequence_altered_entity	denotes	mutants
T796	1515-1520	PR_EXT:000006549	denotes	DMRT7
T797	1541-1554	GO:0001739	denotes	sex chromatin
T798	1545-1569	GO:0016568	denotes	chromatin transformation
T799	1590-1599	GO:0000239	denotes	pachynema
T800	1604-1613	GO:0000240	denotes	diplonema
T801	1631-1636	PR_EXT:000006549	denotes	DMRT7
T802	1646-1653	GO:0065007	denotes	control
T803	1674-1681	GO:0007126	denotes	meiotic
T804	1682-1696	GO:0000803	denotes	sex chromosome
T805	1686-1696	GO_SO_EXT:chromosome	denotes	chromosome
T806	1717-1724	GO:0007126	denotes	meiotic
T807	1725-1738	GO:0001739	denotes	sex chromatin
T808	1742-1747	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T809	1801-1808	NCBITaxon:40674	denotes	mammals
T810	1827-1838	NCBITaxon:7742	denotes	vertebrates
T811	1840-1845	PR_EXT:000006549	denotes	Dmrt7
T812	1877-1884	GO:0007126	denotes	meiosis
T813	1892-1905	GO:0001739	denotes	sex chromatin
T3698	3096-3118	GO:0007548	denotes	Sexual differentiation
T3699	3129-3139	UBERON:0001062	denotes	anatomical
T3700	3141-3154	GO_PATO_EXT:physiological_process_or_quality	denotes	physiological
T3701	3160-3170	GO_PATO_EXT:biological_behavior	denotes	behavioral
T3702	3206-3225	GO:0019953	denotes	sexual reproduction
T3703	3260-3273	CL:0002371	denotes	somatic cells
T3704	3268-3273	CL_GO_EXT:cell	denotes	cells
T3705	3329-3348	GO:0019953	denotes	sexual reproduction
T3706	3366-3373	CL:0000300	denotes	gametes
T3707	3386-3393	CL:0000300	denotes	Gametes
T3708	3511-3517	CL:0000365	denotes	zygote
T3709	3511-3527	GO:0009566	denotes	zygote formation
T3710	3559-3566	CL:0000300	denotes	gametes
T3711	3588-3595	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3712	3633-3640	CL:0000300	denotes	gametes
T3713	3645-3650	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T3714	3677-3686	NCBITaxon:40674	denotes	Mammalian
T3715	3687-3694	GO:0007126	denotes	meiosis
T3716	3698-3707	GO:0065007	denotes	regulated
T3717	3737-3750	GO:0009790	denotes	embryogenesis
T3718	3782-3792	UBERON:0000113	denotes	adult life
T3719	3853-3860	GO:0007126	denotes	meiosis
T3720	3901-3908	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3721	3910-3920	CL:0000586	denotes	germ cells
T3722	3915-3920	CL_GO_EXT:cell	denotes	cells
T3723	3944-3951	GO:0007126	denotes	meiosis
T3724	3959-3965	UBERON:0000922	denotes	embryo
T3725	3984-4002	GO:0007128	denotes	meiotic prophase I
T3726	4019-4026	CL:0000023	denotes	oocytes
T3727	4043-4052	GO_EXT:biological_recruitment	denotes	recruited
T3728	4057-4066	GO:0030728	denotes	ovulation
T3729	4089-4101	GO:0007137	denotes	metaphase II
T3730	4120-4127	GO:0007126	denotes	meiosis
T3731	4134-4147	GO:0009566	denotes	fertilization
T3732	4173-4177	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3733	4173-4185	GO:0007140	denotes	male meiosis
T3734	4206-4213	GO:0007567	denotes	natally
T3735	4251-4258	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3736	4263-4270	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3737	4277-4284	GO:0007126	denotes	meiosis
T3738	4314-4320	CL:0000023	denotes	oocyte
T3739	4367-4371	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3740	4367-4379	GO:0007140	denotes	male meiosis
T3741	4405-4418	CL:0000017	denotes	spermatocytes
T3742	4426-4433	GO:0007126	denotes	meiotic
T3743	4453-4466	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T3744	4471-4481	GO_SO_EXT:chromosome	denotes	chromosome
T3745	4471-4489	GO:0007129	denotes	chromosome pairing
T3746	4491-4499	GO:0007129	denotes	synapsis
T3747	4604-4622	GO:0007143	denotes	meiosis in females
T3748	4615-4622	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3749	4629-4634	NCBITaxon:9606	denotes	human
T3750	4635-4641	CL:0000023	denotes	oocyte
T3751	4642-4652	PATO_SO_EXT:aneuploidy	denotes	aneuploidy
T3752	4688-4693	NCBITaxon:9606	denotes	human
T3753	4694-4699	CL:0000019	denotes	sperm
T3754	4736-4747	GO:0000075	denotes	checkpoints
T3755	4748-4759	GO:0065007	denotes	controlling
T3756	4764-4774	GO:0065007	denotes	monitoring
T3757	4789-4796	GO:0007126	denotes	meiotic
T3758	4812-4817	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T3759	4865-4872	SO_EXT:0000704	denotes	genetic
T3760	4897-4915	GO:0040020	denotes	meiotic regulatory
T3761	4916-4921	SO_EXT:0000704	denotes	genes
T3762	4929-4934	NCBITaxon:10088	denotes	mouse
T3763	4983-4988	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T3764	4997-5004	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3765	5043-5058	GO:0000803	denotes	sex chromosomes
T3766	5047-5058	GO_SO_EXT:chromosome	denotes	chromosomes
T3767	5088-5095	NCBITaxon:40674	denotes	mammals
T3768	5172-5182	GO:0010467	denotes	expression
T3769	5197-5202	SO_EXT:0000704	denotes	genes
T3770	5231-5238	NCBITaxon:40674	denotes	mammals
T3771	5258-5270	GO:0000805	denotes	X chromosome
T3772	5258-5283	GO:0009048	denotes	X chromosome inactivation
T3773	5260-5270	GO_SO_EXT:chromosome	denotes	chromosome
T3774	5287-5294	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3775	5305-5309	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3776	5305-5320	CL:0000015	denotes	male germ cells
T3777	5315-5320	CL_GO_EXT:cell	denotes	cells
T3778	5372-5379	GO:0007126	denotes	meiosis
T3779	5384-5394	GO:0007128	denotes	prophase I
T3780	5416-5427	GO_SO_EXT:chromosome	denotes	chromosomes
T3781	5428-5435	GO:0007129	denotes	synapse
T3782	5451-5464	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T3783	5473-5474	_FRAGMENT	denotes	X
T3784	5481-5491	GO:0000805	denotes	chromosome
T3785	5479-5491	GO:0000806	denotes	Y chromosome
T3786	5481-5491	GO_SO_EXT:chromosome	denotes	chromosome
T3787	5481-5499	GO:0007129	denotes	chromosome pairing
T3788	5572-5583	_FRAGMENT	denotes	portions of
T3789	5589-5599	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome
T3790	5589-5599	GO_SO_EXT:chromosome	denotes	chromosome
T3791	5613-5622	_FRAGMENT	denotes	eutherian
T3792	5637-5644	NCBITaxon:9347	denotes	mammals
T3793	5627-5644	NCBITaxon:9263	denotes	marsupial mammals
T3794	5661-5679	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome regions
T3795	5714-5723	GO:0000785	denotes	chromatin
T3796	5742-5749	GO:0001741	denotes	XY body
T3797	5753-5761	GO:0001741	denotes	sex body
T3798	5783-5790	GO:0001741	denotes	XY body
T3877	7420-7431	NCBITaxon:7742	denotes	Vertebrates
T3799	5859-5863	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3800	5859-5871	GO:0007140	denotes	male meiotic
T3801	5898-5906	CHEBI_PR_EXT:protein	denotes	proteins
T3802	5923-5931	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localize
T3803	5939-5946	GO:0001741	denotes	XY body
T3804	5958-5963	PR_EXT:000004803	denotes	BRCA1
T3805	5965-5968	PR_EXT:000004499	denotes	ATR
T3806	5974-5981	PR_EXT:000043452	denotes	histone
T3807	5974-5981	CHEBI:15358	denotes	histone
T3808	5982-5989	SO_EXT:sequence_variant_or_variation	denotes	variant
T3809	5990-5994	PR_EXT:000008425	denotes	H3.3
T3810	6000-6008	SO_EXT:sequence_alteration_process	denotes	modified
T3811	6009-6017	PR_EXT:000043452	denotes	histones
T3812	6009-6017	CHEBI:15358	denotes	histones
T3813	6026-6039	GO_PATO_EXT:ubiquitination_process_or_quality	denotes	ubiquitinated
T3814	6040-6043	PR_EXT:000027547	denotes	H2A
T3815	6045-6047	GO_PATO_EXT:ubiquitination_process_or_quality	denotes	Ub
T3816	6048-6051	PR_EXT:000027547	denotes	H2A
T3817	6057-6071	GO_PATO_EXT:phosphorylation_process_or_quality	denotes	phosphorylated
T3818	6072-6076	PR_EXT:000008418	denotes	H2AX
T3819	6101-6108	GO:0001741	denotes	XY body
T3820	6114-6129	GO:0000803	denotes	sex chromosomes
T3821	6118-6129	GO_SO_EXT:chromosome	denotes	chromosomes
T3822	6134-6160	GO:0006342	denotes	transcriptionally silenced
T3823	6181-6188	GO:0007126	denotes	meiotic
T3824	6189-6203	GO:0000803	denotes	sex chromosome
T3825	6193-6203	GO_SO_EXT:chromosome	denotes	chromosome
T3826	6229-6236	GO:0001741	denotes	XY body
T3827	6254-6263	GO:0000239	denotes	pachynema
T3828	6290-6295	SO_EXT:0000704	denotes	genes
T3829	6303-6327	GO:0006342	denotes	transcriptionally silent
T3830	6333-6347	GO:0007286	denotes	spermiogenesis
T3831	6374-6383	GO:0016458	denotes	silencing
T3832	6421-6430	GO:0000785	denotes	chromatin
T3833	6431-6436	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marks
T3834	6451-6464	GO:0001739	denotes	sex chromatin
T3835	6483-6490	GO:0007126	denotes	meiotic
T3836	6491-6504	GO:0001739	denotes	sex chromatin
T3837	6521-6531	GO_EXT:regulator	denotes	Regulators
T3838	6535-6557	GO:0007548	denotes	sexual differentiation
T3839	6594-6603	NCBITaxon:1	denotes	organisms
T3840	6674-6684	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T3841	6708-6712	UBERON_EXT:body	denotes	body
T3842	6724-6733	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T3843	6750-6758	GO:0065007	denotes	regulate
T3844	6759-6781	GO:0007548	denotes	sexual differentiation
T3845	6810-6815	NCBITaxon:phylum	denotes	phyla
T3846	6846-6851	SO_EXT:0000704	denotes	genes
T3847	6863-6872	PR_EXT:P23023	denotes	doublesex
T3848	6874-6877	PR_EXT:P23023	denotes	dsx
T3849	6882-6892	NCBITaxon:7215	denotes	Drosophila
T3850	6908-6917	PR_EXT:P23023	denotes	Doublesex
T3851	6918-6923	PR_EXT:O18214	denotes	MAB-3
T3852	6924-6927	CHEBI_SO_EXT:DNA	denotes	DNA
T3853	6928-6935	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3854	6936-6941	SO_EXT:sequence_or_structure_motif	denotes	motif
T3855	6956-6962	SO_EXT:0000417	denotes	domain
T3856	6975-6981	SO_EXT:0000417	denotes	domain
T3857	6982-6990	SO_EXT:sequence_coding_function	denotes	encoding
T3858	6991-6996	SO_EXT:0000704	denotes	genes
T3859	7016-7024	GO:0065007	denotes	regulate
T3860	7044-7066	GO:0007548	denotes	sexual differentiation
T3861	7070-7077	NCBITaxon:6960	denotes	insects
T3862	7079-7088	NCBITaxon:6231	denotes	nematodes
T3863	7094-7101	NCBITaxon:40674	denotes	mammals
T3864	7112-7117	PR_EXT:O18214	denotes	mab-3
T3865	7118-7122	SO_EXT:0000704	denotes	gene
T3866	7126-7148	NCBITaxon:6239	denotes	Caenorhabditis elegans
T3867	7191-7194	PR_EXT:P23023	denotes	DSX
T3868	7239-7247	SO_EXT:sequence_substitution_process	denotes	replaced
T3869	7255-7259	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3870	7255-7274	PR_EXT:P23023-1	denotes	male isoform of DSX
T3871	7260-7267	SO_EXT:0001060	denotes	isoform
T3872	7314-7322	SO_EXT:biological_sequence	denotes	sequence
T3873	7332-7337	SO_EXT:0000704	denotes	genes
T3874	7352-7364	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T3875	7384-7390	SO_EXT:0000417	denotes	domain
T3876	7398-7407	GO_EXT:regulator	denotes	regulator
T3878	7445-7451	SO_EXT:0000417	denotes	domain
T3879	7452-7457	SO_EXT:0000704	denotes	genes
T3880	7520-7525	SO_EXT:0000704	denotes	genes
T3881	7531-7538	GO:0065007	denotes	control
T3882	7539-7561	GO:0007548	denotes	sexual differentiation
T3883	7563-7570	NCBITaxon:40674	denotes	Mammals
T3884	7585-7591	SO_EXT:0000417	denotes	domain
T3885	7592-7597	SO_EXT:0000704	denotes	genes
T3886	7604-7609	SO_EXT:0000704	denotes	genes
T3887	7656-7660	CHEBI_SO_EXT:mRNA	denotes	mRNA
T3888	7661-7671	GO:0010467	denotes	expression
T3889	7707-7712	SO_EXT:0000704	denotes	genes
T3890	7714-7719	PR_EXT:000006542	denotes	Dmrt1
T3891	7724-7733	GO:0010467	denotes	expressed
T3892	7741-7756	GO_RO_EXT:developmental_differentiation_process	denotes	differentiating
T3893	7757-7761	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3894	7762-7776	UBERON:0005294	denotes	genital ridges
T3895	7781-7786	UBERON:0007023	denotes	adult
T3896	7787-7793	UBERON:0000473	denotes	testis
T3897	7797-7804	NCBITaxon:40674	denotes	mammals
T3898	7806-7811	NCBITaxon:8782	denotes	birds
T3899	7813-7817	NCBITaxon_EXT:fish	denotes	fish
T3900	7823-7831	NCBITaxon_EXT:reptile	denotes	reptiles
T3901	7848-7858	SO_EXT:sequence_duplication_process	denotes	duplicated
T3902	7859-7864	PR_EXT:000006542	denotes	Dmrt1
T3903	7865-7869	SO_EXT:0000704	denotes	gene
T3904	7887-7888	GO:0000806	denotes	Y
T3905	7896-7902	UBERON:0000473	denotes	testis
T3906	7915-7919	SO_EXT:0000704	denotes	gene
T3907	7927-7938	NCBITaxon:8088	denotes	Medaka fish
T3908	7948-7953	NCBITaxon:9606	denotes	Human
T3909	7954-7959	PR_EXT:000006542	denotes	DMRT1
T3910	7971-7980	GO:0030849	denotes	autosomal
T3911	8041-8051	UBERON:0000473	denotes	testicular
T3912	8041-8063	GO:0008584	denotes	testicular development
T3913	8112-8116	NCBITaxon:10088	denotes	mice
T3914	8134-8138	SO_EXT:sequence_nullness	denotes	null
T3915	8139-8147	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3916	8151-8156	PR_EXT:000006542	denotes	Dmrt1
T3917	8180-8186	UBERON:0000473	denotes	testis
T3918	8187-8202	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3919	8218-8228	CL:0000586	denotes	germ cells
T3920	8223-8228	CL_GO_EXT:cell	denotes	cells
T3921	8233-8246	CL:0000216	denotes	Sertoli cells
T3922	8241-8246	CL_GO_EXT:cell	denotes	cells
T3923	8253-8259	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	Female
T3924	8260-8264	NCBITaxon:10088	denotes	mice
T3925	8265-8271	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3926	8275-8280	PR_EXT:000006545	denotes	Dmrt4
T3927	8290-8296	CL:0000025	denotes	ovular
T3928	8297-8306	UBERON_EXT:follicle	denotes	follicles
T3929	8329-8333	SO_EXT:0000704	denotes	gene
T3930	8355-8362	UBERON:0000991	denotes	gonadal
T3931	8355-8374	GO:0008406	denotes	gonadal development
T3932	8438-8444	SO_EXT:0000417	denotes	domain
T3933	8445-8450	SO_EXT:0000704	denotes	genes
T3934	8454-8476	GO:0007548	denotes	sexual differentiation
T3935	8492-8501	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T3936	8512-8522	NCBITaxon:7742	denotes	vertebrate
T3937	8528-8532	SO_EXT:0000704	denotes	gene
T3938	8560-8582	GO:0007548	denotes	sexual differentiation
T3939	8584-8589	PR_EXT:000006543	denotes	Dmrt2
T3940	8636-8640	NCBITaxon:10088	denotes	mice
T3941	8645-8649	NCBITaxon_EXT:fish	denotes	fish
T3942	8690-8700	GO:0010467	denotes	expression
T3943	8721-8726	PR_EXT:000006549	denotes	Dmrt7
T3944	8727-8731	SO_EXT:0000704	denotes	gene
T3945	8739-8744	NCBITaxon:10088	denotes	mouse
T3946	8746-8751	PR_EXT:000006549	denotes	Dmrt7
T3947	8755-8764	GO:0010467	denotes	expressed
T3948	8777-8782	UBERON:0000991	denotes	gonad
T3949	8811-8816	SO_EXT:0000704	denotes	genes
T3950	8855-8862	NCBITaxon:40674	denotes	mammals
T3951	8877-8886	NCBITaxon:40674	denotes	mammalian
T3952	8887-8898	NCBITaxon:7742	denotes	vertebrates
T3953	8921-8926	PR_EXT:000006549	denotes	DMRT7
T3954	8927-8934	CHEBI_PR_EXT:protein	denotes	protein
T3955	8938-8947	GO:0010467	denotes	expressed
T3956	8956-8966	CL:0000586	denotes	germ cells
T3957	8961-8966	CL_GO_EXT:cell	denotes	cells
T3958	8986-8995	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T3959	9003-9010	GO:0001741	denotes	XY body
T3960	9014-9018	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3961	9014-9018	_FRAGMENT	denotes	male
T3962	9029-9039	CL:0000015	denotes	germ cells
T3963	9019-9028	GO:0000239	denotes	pachytene
T3964	9034-9039	CL_GO_EXT:cell	denotes	cells
T3965	9090-9094	SO_EXT:sequence_nullness	denotes	null
T3966	9095-9103	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3967	9107-9112	PR_EXT:000006549	denotes	Dmrt7
T3968	9120-9125	NCBITaxon:10088	denotes	mouse
T3969	9140-9145	PR_EXT:000006549	denotes	Dmrt7
T3970	9161-9166	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T3971	9194-9203	GO:0000239	denotes	pachytene
T3972	9213-9220	GO:0007126	denotes	meiotic
T3973	9221-9229	GO:0051324	denotes	prophase
T3974	9253-9260	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T3975	9270-9276	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3976	9277-9282	CL_GO_EXT:cell	denotes	cells
T3977	9299-9308	GO:0000240	denotes	diplonema
T3978	9322-9335	GO:0001739	denotes	sex chromatin
T3979	9396-9401	PR_EXT:000006549	denotes	Dmrt7
T3980	9429-9433	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T3981	9443-9452	GO:0000785	denotes	chromatin
T3982	9443-9463	GO:0016568	denotes	chromatin transition
T3983	9472-9481	GO:0000239	denotes	pachynema
T3984	9486-9495	GO:0000240	denotes	diplonema
T3985	9503-9510	GO:0007126	denotes	meiotic
T3986	9511-9519	GO:0051324	denotes	prophase
T6606	9531-9541	GO:0010467	denotes	Expression
T6607	9545-9550	PR_EXT:000006549	denotes	DMRT7
T6608	9551-9559	CHEBI_PR_EXT:protein	denotes	Proteins
T6609	9563-9569	UBERON:0000473	denotes	Testis
T6610	9583-9587	CHEBI_SO_EXT:mRNA	denotes	mRNA
T6611	9588-9598	GO:0010467	denotes	expression
T6612	9629-9636	GO:0007126	denotes	meiotic
T6613	9650-9655	PR_EXT:000006549	denotes	Dmrt7
T6614	9670-9680	GO:0010467	denotes	expression
T6615	9684-9689	PR_EXT:000006549	denotes	Dmrt7
T6616	9690-9694	CHEBI_SO_EXT:mRNA	denotes	mRNA
T6617	9708-9714	UBERON:0000991	denotes	gonads
T6618	9751-9756	UBERON:0000992	denotes	ovary
T6619	9758-9763	PR_EXT:000006549	denotes	Dmrt7
T6620	9764-9768	CHEBI_SO_EXT:mRNA	denotes	mRNA
T6621	9835-9842	GO:0007126	denotes	meiosis
T6622	9859-9882	GO:0006279	denotes	pre-meiotic replication
T6623	9890-9899	GO:0000239	denotes	pachytene
T6624	9919-9924	PR_EXT:000006549	denotes	Dmrt7
T6625	9925-9935	GO:0010467	denotes	expression
T6626	9947-9954	GO:0007126	denotes	meiotic
T6627	9961-9967	UBERON:0000473	denotes	testis
T6628	10024-10029	UBERON:0007023	denotes	adult
T6629	10030-10035	PR_EXT:000006549	denotes	Dmrt7
T6630	10036-10046	GO:0010467	denotes	expression
T6631	10067-10088	GO_EXT:0003964	denotes	reverse transcriptase
T6632	10090-10092	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T6633	10101-10105	CHEBI_SO_EXT:mRNA	denotes	mRNA
T6634	10115-10120	UBERON:0007023	denotes	adult
T6635	10121-10127	UBERON:0000062	denotes	organs
T6636	10148-10153	PR_EXT:000006549	denotes	Dmrt7
T6637	10154-10158	CHEBI_SO_EXT:mRNA	denotes	mRNA
T6638	10159-10169	GO:0010467	denotes	expression
T6639	10177-10183	UBERON:0000473	denotes	testis
T6640	10199-10209	GO:0010467	denotes	expression
T6641	10213-10218	UBERON:0000948	denotes	heart
T6642	10241-10247	UBERON:0000479	denotes	tissue
T6643	10294-10299	PR_EXT:000006549	denotes	Dmrt7
T6644	10300-10304	CHEBI_SO_EXT:mRNA	denotes	mRNA
T6645	10305-10315	GO:0010467	denotes	expression
T6646	10327-10332	GO:0007567	denotes	natal
T6647	10333-10339	UBERON:0000473	denotes	testis
T6648	10333-10351	GO:0008584	denotes	testis development
T6649	10372-10382	GO:0010467	denotes	expression
T6650	10448-10457	GO:0000239	denotes	pachytene
T6651	10501-10516	GO:0007283	denotes	spermatogenesis
T6652	11369-11374	PR_EXT:000006549	denotes	DMRT7
T6653	11375-11382	CHEBI_PR_EXT:protein	denotes	protein
T6654	11383-11393	GO:0010467	denotes	expression
T6655	11411-11419	GO:0042571	denotes	antibody
T6656	11432-11442	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T6657	11458-11465	CHEBI_PR_EXT:protein	denotes	protein
T6658	11471-11479	GO:0042571	denotes	antibody
T6659	11530-11536	SO_EXT:0000417	denotes	domain
T6660	11584-11590	SO_EXT:0000417	denotes	domain
T6661	11591-11599	CHEBI_PR_EXT:protein	denotes	proteins
T6662	11642-11647	PR_EXT:000006549	denotes	DMRT7
T6663	11652-11656	UBERON:0001977	denotes	sera
T6664	11669-11674	PR_EXT:000006549	denotes	DMRT7
T6665	11675-11682	CHEBI_PR_EXT:protein	denotes	protein
T6666	11686-11695	GO:0010467	denotes	expressed
T6667	11726-11735	GO:0000239	denotes	pachytene
T6668	11736-11749	CL:0000017	denotes	spermatocytes
T6669	11777-11782	CL:0000019	denotes	sperm
T6670	11815-11824	CL:0000586	denotes	germ cell
T6671	11820-11824	CL_GO_EXT:cell	denotes	cell
T6672	11841-11854	CL:0000020	denotes	spermatogonia
T6673	11865-11875	CL:0000018	denotes	spermatids
T6674	11895-11900	PR_EXT:000006549	denotes	DMRT7
T6675	11901-11908	CHEBI_PR_EXT:protein	denotes	protein
T6676	11912-11925	CL:0002371	denotes	somatic cells
T6677	11920-11925	CL_GO_EXT:cell	denotes	cells
T6678	11934-11947	CL:0000216	denotes	Sertoli cells
T6679	11942-11947	CL_GO_EXT:cell	denotes	cells
T6680	11949-11972	CL:0002481	denotes	peritubular myoid cells
T6681	11953-11960	UBERON:0000025	denotes	tubular
T6682	11967-11972	CL_GO_EXT:cell	denotes	cells
T6683	11977-11989	CL:0000178	denotes	Leydig cells
T6684	11984-11989	CL_GO_EXT:cell	denotes	cells
T6685	12023-12032	GO:0000239	denotes	pachytene
T6686	12043-12048	PR_EXT:000006549	denotes	DMRT7
T6687	12049-12059	GO:0010467	denotes	expression
T6688	12087-12095	GO:0042571	denotes	antibody
T6689	12099-12104	PR_EXT:000007857	denotes	GATA1
T6690	12115-12124	GO:0010467	denotes	expressed
T6691	12128-12141	CL:0000216	denotes	Sertoli cells
T6692	12136-12141	CL_GO_EXT:cell	denotes	cells
T6693	12190-12195	PR_EXT:000006549	denotes	DMRT7
T6694	12199-12208	GO:0010467	denotes	expressed
T6695	12225-12234	GO:0000239	denotes	pachytene
T6696	12235-12248	CL:0000017	denotes	spermatocytes
T6697	12349-12358	GO:0000239	denotes	pachytene
T6698	12359-12372	CL:0000017	denotes	spermatocytes
T6699	12374-12379	PR_EXT:000006549	denotes	DMRT7
T6700	12403-12410	GO:0001741	denotes	XY body
T6701	12415-12423	GO:0001741	denotes	sex body
T6702	12444-12453	GO:0000785	denotes	chromatin
T6703	12478-12493	GO:0000803	denotes	sex chromosomes
T6704	12482-12493	GO_SO_EXT:chromosome	denotes	chromosomes
T6705	12509-12524	GO_EXT:transcription	denotes	transcriptional
T6706	12542-12564	GO:0031507	denotes	heterochromatinization
T6707	12612-12620	GO:0051324	denotes	prophase
T6708	12624-12633	NCBITaxon:40674	denotes	mammalian
T6709	12634-12638	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T6710	12634-12646	GO:0007140	denotes	male meiosis
T6711	12663-12668	PR_EXT:000006549	denotes	DMRT7
T6712	12669-12676	CHEBI_PR_EXT:protein	denotes	protein
T6713	12677-12687	GO:0010467	denotes	expression
T6714	12695-12702	GO:0001741	denotes	XY body
T6715	12722-12727	NCBITaxon:10088	denotes	mouse
T6716	12728-12734	UBERON:0000473	denotes	testis
T6717	12748-12753	PR_EXT:000006549	denotes	DMRT7
T6718	12758-12792	PR_EXT:000015829	denotes	small ubiquitin-related modifier 1
T6719	12794-12800	PR_EXT:000015829	denotes	SUMO-1
T6720	12832-12839	GO:0001741	denotes	XY body
T6721	12847-12856	GO:0000239	denotes	pachynema
T6722	12866-12871	PR_EXT:000006549	denotes	DMRT7
T6723	12876-12882	PR_EXT:000015829	denotes	SUMO-1
T6724	12890-12899	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T6725	12917-12922	PR_EXT:000006549	denotes	DMRT7
T6726	12923-12930	CHEBI_PR_EXT:protein	denotes	protein
T6727	12949-12958	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T6728	12966-12973	GO:0001741	denotes	XY body
T6729	13005-13012	GO:0001741	denotes	XY body
T6730	13013-13025	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T6731	13029-13034	PR_EXT:000006549	denotes	DMRT7
T6732	13064-13071	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T6733	13082-13084	GO_PATO_EXT:ubiquitination_process_or_quality	denotes	Ub
T6734	13085-13088	PR_EXT:000027547	denotes	H2A
T6735	13119-13124	PR_EXT:000006549	denotes	DMRT7
T6736	13147-13156	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T6737	13164-13171	GO:0001741	denotes	XY body
T6738	13219-13229	UBERON:0000483	denotes	epithelial
T6739	13255-13260	PR_EXT:000006549	denotes	DMRT7
T6740	13261-13270	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T6741	13278-13285	GO:0001741	denotes	XY body
T6742	13304-13313	GO:0000239	denotes	pachynema
T6743	13353-13362	GO:0000239	denotes	pachynema
T6744	13382-13391	GO:0000240	denotes	diplonema
T6745	13417-13429	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T6746	13459-13466	GO:0007126	denotes	meiotic
T6747	13488-13493	PR_EXT:000006549	denotes	DMRT7
T6748	13515-13524	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T6749	13528-13533	CL:0000019	denotes	sperm
T6750	13540-13548	GO:0042571	denotes	antibody
T6751	13576-13583	GO:0005634	denotes	nuclear
T6752	13596-13601	CL:0000019	denotes	sperm
T6753	13607-13616	GO:0002177	denotes	manchette
T6754	13651-13661	UBERON:0000483	denotes	epithelial
T6755	13678-13683	PR_EXT:000006549	denotes	DMRT7
T6756	13684-13693	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T6757	13701-13708	GO:0001741	denotes	XY body
T6758	13712-13725	CL:0000017	denotes	spermatocytes
T9677	18353-18362	GO:0000239	denotes	pachytene
T8066	14841-14848	NCBITaxon:33208	denotes	animals
T8067	13756-13764	SO_EXT:sequence_deletion_entity_or_process	denotes	Deletion
T8068	13768-13773	PR_EXT:000006549	denotes	Dmrt7
T8069	13818-13823	PR_EXT:000006549	denotes	Dmrt7
T8070	13838-13843	PR_EXT:000006549	denotes	Dmrt7
T8071	13844-13845	SO_EXT:sequence_nullness_or_absence	denotes	−
T8072	13846-13847	SO_EXT:sequence_nullness_or_absence	denotes	−
T8073	13848-13852	NCBITaxon:10088	denotes	mice
T8074	13879-13888	UBERON:0000922	denotes	embryonic
T8075	13879-13893	_FRAGMENT	denotes	embryonic stem
T8076	13899-13904	CL:0002322	denotes	cells
T8077	13895-13897	_FRAGMENT	denotes	ES
T8078	13899-13904	CL_GO_EXT:cell	denotes	cells
T8079	13952-13957	PR_EXT:000006549	denotes	Dmrt7
T8080	13958-13962	SO_EXT:0000704	denotes	gene
T8081	13972-13977	SO_EXT:0000147	denotes	exons
T8082	13990-13996	SO_EXT:0000417	denotes	domain
T8083	13997-14004	SO_EXT:sequence_coding_function	denotes	encoded
T8084	14029-14034	SO_EXT:0000147	denotes	exons
T8085	14051-14057	SO_EXT:0000417	denotes	domain
T8086	14093-14098	SO_EXT:0000704	denotes	genes
T8087	14110-14115	PR_EXT:O18214	denotes	mab-3
T8088	14129-14132	PR_EXT:P23023	denotes	dsx
T8089	14184-14190	SO:0000359	denotes	floxed
T8090	14192-14198	SO_EXT:0001023	denotes	allele
T8091	14215-14221	SO_EXT:0000417	denotes	domain
T8092	14233-14238	SO_EXT:0000147	denotes	exons
T8093	14242-14247	PR_EXT:000006549	denotes	Dmrt7
T8094	14252-14259	SO:0000357	denotes	flanked
T8095	14293-14304	GO_EXT:recombinase	denotes	recombinase
T8096	14306-14316	SO_EXT:0000346	denotes	loxP sites
T8097	14323-14339	SO_EXT:0001644	denotes	targeting vector
T8098	14357-14365	CHEBI:7507	denotes	neomycin
T8099	14377-14385	SO_EXT:0005853	denotes	cassette
T8100	14387-14390	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T8101	14392-14399	SO:0000357	denotes	flanked
T8102	14403-14425	SO_EXT:0000350	denotes	Flpe recognition sites
T8103	14448-14457	SO_EXT:biological_sequence	denotes	sequences
T8104	14474-14487	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T8105	14506-14512	SO_EXT:0000417	denotes	domain
T8106	14521-14540	GO:0006413	denotes	translational start
T8107	14521-14545	SO_EXT:0000318	denotes	translational start site
T8108	14574-14578	SO_EXT:sequence_nullness	denotes	null
T8109	14579-14585	SO_EXT:0001023	denotes	allele
T8110	14629-14636	CL:0002322	denotes	ES cell
T8111	14632-14636	CL_GO_EXT:cell	denotes	cell
T8112	14637-14643	SO_EXT:sequence_cloned_entity	denotes	clones
T8113	14691-14696	CL_GO_EXT:cell	denotes	cells
T8114	14706-14712	SO_EXT:sequence_cloned_entity	denotes	clones
T8115	14726-14737	UBERON:0000358	denotes	blastocysts
T8116	14748-14755	NCBITaxon:33208	denotes	animals
T8117	14766-14770	CL_GO_EXT:cell	denotes	cell
T8118	14802-14808	SO_EXT:0001023	denotes	allele
T8119	14854-14858	GO_EXT:breeding	denotes	bred
T8120	14862-14869	PR_EXT:000003676	denotes	β-actin
T8121	14874-14878	NCBITaxon:10088	denotes	mice
T8122	14882-14888	SO_EXT:sequence_deletion_process	denotes	delete
T8123	14896-14902	SO_EXT:0000417	denotes	domain
T8124	14903-14911	SO_EXT:sequence_coding_function	denotes	encoding
T8125	14912-14917	SO_EXT:0000147	denotes	exons
T8126	14934-14939	PR_EXT:000006549	denotes	Dmrt7
T8127	14941-14947	SO_EXT:0001023	denotes	allele
T8128	14960-14970	SO_EXT:transgenic_entity	denotes	transgenic
T8129	14971-14975	NCBITaxon:10088	denotes	mice
T8130	14979-14985	SO_EXT:sequence_deletion_process	denotes	delete
T8131	14990-14993	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T8132	14994-15002	SO_EXT:0005853	denotes	cassette
T8133	15019-15024	PR_EXT:000006549	denotes	Dmrt7
T8134	15024-15028	SO:0000359	denotes	flox
T8135	15029-15035	SO_EXT:0001023	denotes	allele
T8136	15037-15042	PR_EXT:000006549	denotes	Dmrt7
T8137	15042-15043	SO_EXT:normal_or_wild_type_or_present	denotes	+
T8138	15044-15045	SO_EXT:sequence_nullness_or_absence	denotes	−
T8139	15046-15050	NCBITaxon:10088	denotes	mice
T8140	15061-15065	GO_EXT:breeding	denotes	bred
T8141	15078-15083	PR_EXT:000006549	denotes	Dmrt7
T8142	15083-15084	SO_EXT:sequence_nullness_or_absence	denotes	−
T8143	15085-15086	SO_EXT:sequence_nullness_or_absence	denotes	−
T8144	15087-15091	NCBITaxon:10088	denotes	mice
T8145	15127-15132	PR_EXT:000006549	denotes	DMRT7
T8146	15133-15140	CHEBI_PR_EXT:protein	denotes	protein
T8147	15144-15149	PR_EXT:000006549	denotes	Dmrt7
T8148	15149-15150	SO_EXT:sequence_nullness_or_absence	denotes	−
T8149	15151-15152	SO_EXT:sequence_nullness_or_absence	denotes	−
T8150	15152-15158	UBERON:0000473	denotes	testes
T8151	15171-15178	GO:0007126	denotes	meiotic
T8152	15192-15197	PR_EXT:000006549	denotes	Dmrt7
T8153	15198-15205	SO_EXT:sequence_altered_entity	denotes	mutants
T8154	15236-15242	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8155	15243-15249	UBERON:0000473	denotes	testes
T8156	15350-15355	PR_EXT:000006549	denotes	DMRT7
T8157	15356-15363	CHEBI_PR_EXT:protein	denotes	protein
T8158	15371-15377	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8159	15378-15384	UBERON:0000473	denotes	testes
T9589	15387-15392	PR_EXT:000006549	denotes	Dmrt7
T9590	15409-15413	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Male
T9591	15409-15413	_FRAGMENT	denotes	Male
T9592	15429-15442	GO:0048232	denotes	Gametogenesis
T9593	15422-15428	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	Female
T9594	15422-15442	GO:0007292	denotes	Female Gametogenesis
T9595	15443-15451	GO_EXT:breeding	denotes	Breeding
T9596	15455-15460	PR_EXT:000006549	denotes	Dmrt7
T9597	15495-15501	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9598	15565-15569	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Male
T9599	15574-15580	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T9600	15592-15599	SO_EXT:sequence_altered_entity	denotes	mutants
T9601	15613-15617	GO:0040007	denotes	grew
T9602	15621-15630	UBERON:0000113	denotes	adulthood
T9603	15662-15677	GO:0019098	denotes	sexual behavior
T9604	15679-15685	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	Female
T9605	15764-15771	UBERON:0000992	denotes	ovarian
T9606	15854-15859	PR_EXT:000006549	denotes	Dmrt7
T9607	15871-15877	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9608	15878-15883	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T9609	15918-15924	UBERON:0000473	denotes	testes
T9610	15980-15989	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9611	15990-15995	UBERON:0007023	denotes	adult
T9612	16048-16054	UBERON:0000473	denotes	testis
T9613	16048-16066	GO:0008584	denotes	testis development
T9614	16077-16082	PR_EXT:000006549	denotes	Dmrt7
T9615	16083-16090	SO_EXT:sequence_altered_entity	denotes	mutants
T9616	16108-16114	UBERON:0000473	denotes	testes
T9617	16118-16127	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9618	16132-16138	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9619	16176-16191	GO:0007283	denotes	spermatogenesis
T9620	16206-16211	GO:0007567	denotes	natal
T9621	16226-16232	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9622	16233-16239	UBERON:0000473	denotes	testes
T9623	16279-16285	UBERON:0000473	denotes	testis
T9624	16336-16345	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9625	16375-16388	CL:0000020	denotes	spermatogonia
T9626	16399-16406	GO:0007126	denotes	meiotic
T9627	16407-16417	CL:0000586	denotes	germ cells
T9628	16412-16417	CL_GO_EXT:cell	denotes	cells
T9629	16479-16485	UBERON:0000473	denotes	testes
T9630	16493-16498	PR_EXT:000006549	denotes	Dmrt7
T9631	16499-16505	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9632	16506-16510	NCBITaxon:10088	denotes	mice
T9633	16521-16525	GO:0040007	denotes	grow
T9634	16608-16613	PR_EXT:000006549	denotes	Dmrt7
T9635	16614-16620	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9636	16621-16627	UBERON:0000473	denotes	testes
T9637	16642-16652	CL:0000586	denotes	germ cells
T9638	16647-16652	CL_GO_EXT:cell	denotes	cells
T9639	16663-16672	GO:0000239	denotes	pachynema
T9640	16684-16693	_FRAGMENT	denotes	stages of
T9641	16699-16704	GO:0022403	denotes	cells
T9642	16694-16704	CL:0000586	denotes	germ cells
T9643	16699-16704	CL_GO_EXT:cell	denotes	cells
T9644	16745-16750	PR_EXT:000006549	denotes	Dmrt7
T9645	16751-16757	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9646	16758-16762	NCBITaxon:10088	denotes	mice
T9647	16784-16791	GO:0007126	denotes	meiotic
T9648	16792-16802	CL:0000018	denotes	spermatids
T9649	16812-16822	UBERON:0001301	denotes	epididymal
T9650	16823-16834	CL:0000019	denotes	spermatozoa
T9651	16851-16856	CL_GO_EXT:cell	denotes	cells
T9652	16878-16887	CL:0000018	denotes	spermatid
T9653	16901-16908	GO:0007126	denotes	meiotic
T9654	16980-16985	PR_EXT:000006549	denotes	Dmrt7
T9655	16986-16994	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T9656	17012-17017	PR_EXT:000006549	denotes	Dmrt7
T9657	17018-17024	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9658	17025-17032	UBERON:0000025	denotes	tubules
T9659	17077-17090	CL:0000216	denotes	Sertoli cells
T9660	17085-17090	CL_GO_EXT:cell	denotes	cells
T9661	17095-17108	CL:0000020	denotes	spermatogonia
T9662	17131-17152	CL:0000656	denotes	primary spermatocytes
T9663	17172-17179	UBERON:0000025	denotes	tubules
T9664	17188-17208	CL:0000228	denotes	multinucleated cells
T9665	17193-17202	GO:0005634	denotes	nucleated
T9666	17203-17208	CL_GO_EXT:cell	denotes	cells
T9667	17213-17218	CL_GO_EXT:cell	denotes	cells
T9668	17213-17223	_FRAGMENT	denotes	cells with
T9669	17239-17245	CL:0002242	denotes	nuclei
T9670	17239-17245	GO:0005634	denotes	nuclei
T9671	17266-17275	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9672	17266-17281	CL:0000445	denotes	apoptotic cells
T9673	17276-17281	CL_GO_EXT:cell	denotes	cells
T9674	18318-18323	PR_EXT:000006549	denotes	Dmrt7
T9675	18324-18330	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9676	18331-18337	UBERON:0000473	denotes	testes
T9678	18363-18368	CL_GO_EXT:cell	denotes	cells
T9679	18421-18426	CL_GO_EXT:cell	denotes	cells
T9680	18431-18441	GO_EXT:killing	denotes	eliminated
T9681	18445-18454	GO:0006915	denotes	apoptosis
T9682	18465-18470	PR_EXT:000006549	denotes	Dmrt7
T9683	18471-18477	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9684	18478-18484	UBERON:0000473	denotes	testes
T9685	18512-18521	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9686	18512-18527	CL:0000445	denotes	apoptotic cells
T9687	18522-18527	CL_GO_EXT:cell	denotes	cells
T9688	18542-18551	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9689	18580-18586	UBERON:0000025	denotes	tubule
T9690	18614-18623	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9691	18624-18630	GO:0005634	denotes	nuclei
T9692	18663-18668	PR_EXT:000006549	denotes	Dmrt7
T9693	18669-18676	SO_EXT:sequence_altered_entity	denotes	mutants
T9694	18691-18700	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9695	18752-18761	GO:0006915	denotes	apoptosis
T9696	18778-18784	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9697	18785-18791	UBERON:0000473	denotes	testes
T9698	18816-18823	SO_EXT:sequence_altered_entity	denotes	mutants
T9699	18830-18839	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9700	18830-18845	CL:0000445	denotes	apoptotic cells
T9701	18840-18845	CL_GO_EXT:cell	denotes	cells
T9702	18872-18879	UBERON:0000025	denotes	tubules
T9703	18893-18902	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9704	18893-18908	CL:0000445	denotes	apoptotic cells
T9705	18903-18908	CL_GO_EXT:cell	denotes	cells
T9706	18912-18921	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9707	18944-18963	UBERON:0001343	denotes	seminiferous tubule
T9708	18990-19003	CL:0000216	denotes	Sertoli cells
T9709	18998-19003	CL_GO_EXT:cell	denotes	cells
T9710	19045-19054	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9711	19059-19065	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9712	19066-19072	UBERON:0000473	denotes	testes
T9713	19107-19119	CL:0002371	denotes	somatic cell
T9714	19115-19119	CL_GO_EXT:cell	denotes	cell
T9715	19115-19129	GO:0006915	denotes	cell apoptosis
T9716	19133-19140	SO_EXT:sequence_altered_entity	denotes	mutants
T9717	19206-19211	PR_EXT:000006549	denotes	Dmrt7
T9718	19230-19237	GO:0007126	denotes	meiotic
T9719	19261-19270	GO:0000239	denotes	pachynema
T9720	19287-19298	GO_EXT:killing	denotes	elimination
T9721	19303-19312	GO:0006915	denotes	apoptosis
T9722	19330-19335	CL_GO_EXT:cell	denotes	cells
T10894	19564-19568	CL:0000670	denotes	PGCs
T10895	19573-19586	CL:0000020	denotes	spermatogonia
T10876	19338-19347	GO:0000239	denotes	Pachytene
T10877	19358-19363	PR_EXT:000006549	denotes	Dmrt7
T10878	19364-19370	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T10879	19371-19381	CL:0000586	denotes	Germ Cells
T10880	19376-19381	CL_GO_EXT:cell	denotes	Cells
T10881	19403-19416	GO:0007283	denotes	spermatogenic
T10882	19432-19437	PR_EXT:000006549	denotes	Dmrt7
T10883	19437-19438	SO_EXT:sequence_nullness_or_absence	denotes	−
T10884	19439-19440	SO_EXT:sequence_nullness_or_absence	denotes	−
T10885	19441-19445	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T10886	19441-19456	CL:0000015	denotes	male germ cells
T10887	19451-19456	CL_GO_EXT:cell	denotes	cells
T10888	19468-19471	GO:0016265	denotes	die
T10889	19481-19491	GO:0042571	denotes	antibodies
T10890	19523-19532	CL:0000586	denotes	germ cell
T10891	19528-19532	CL_GO_EXT:cell	denotes	cell
T10892	19533-19540	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T10893	19551-19560	GO:0010467	denotes	expressed
T10896	19600-19609	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T10897	19610-19615	UBERON:0007023	denotes	adult
T10898	19616-19622	UBERON:0000473	denotes	testis
T10899	19657-19662	CL_GO_EXT:cell	denotes	cells
T10900	19680-19684	CL_GO_EXT:cell	denotes	cell
T10901	19707-19713	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T10902	19739-19744	CL_GO_EXT:cell	denotes	cells
T10903	19781-19788	UBERON:0000025	denotes	tubules
T10904	19809-19814	CL_GO_EXT:cell	denotes	cells
T10905	19841-19849	GO:0042571	denotes	antibody
T10906	19861-19874	CL:0000017	denotes	spermatocytes
T10907	19882-19891	GO:0000237	denotes	leptotene
T10908	19901-19910	GO:0000239	denotes	pachytene
T10909	19924-19929	PR_EXT:000006549	denotes	Dmrt7
T10910	19930-19936	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T10911	19937-19943	UBERON:0000473	denotes	testes
T10912	19961-19966	CL_GO_EXT:cell	denotes	cells
T10913	20051-20056	CL_GO_EXT:cell	denotes	cells
T10914	20104-20111	UBERON:0000025	denotes	tubules
T10915	20136-20144	GO:0042571	denotes	antibody
T10916	20158-20166	PR_EXT:000005573	denotes	calmegin
T10917	20167-20174	CHEBI_PR_EXT:protein	denotes	protein
T10918	20175-20184	GO:0010467	denotes	expressed
T10919	20188-20197	GO:0000239	denotes	pachytene
T10920	20198-20211	CL:0000017	denotes	spermatocytes
T10921	20230-20240	CL:0000018	denotes	spermatids
T10922	20308-20313	CL_GO_EXT:cell	denotes	cells
T10923	20330-20336	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T10924	20337-20343	UBERON:0000473	denotes	testes
T10925	20356-20365	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T10926	20413-20418	CL_GO_EXT:cell	denotes	cells
T10927	20427-20440	GO:0098762	denotes	meiotic stage
T10928	20447-20459	CL:0000017	denotes	spermatocyte
T10929	20478-20488	GO_SO_EXT:chromosome	denotes	chromosome
T10930	20478-20496	GO:0007129	denotes	chromosome-pairing
T10931	20520-20525	PR_EXT:000015865	denotes	SYCP3
T10932	20546-20566	GO:0000795	denotes	synaptonemal complex
T10933	20593-20598	PR_EXT:000006549	denotes	Dmrt7
T10934	20599-20606	SO_EXT:sequence_altered_entity	denotes	mutants
T10935	20618-20627	GO:0000239	denotes	pachytene
T10936	20628-20633	CL_GO_EXT:cell	denotes	cells
T10937	20670-20675	CL_GO_EXT:cell	denotes	cells
T10938	20684-20693	GO:0000239	denotes	pachynema
T10939	20747-20754	GO:0007126	denotes	meiotic
T10940	20765-20770	PR_EXT:000006549	denotes	Dmrt7
T10941	20771-20778	SO_EXT:sequence_altered_entity	denotes	mutants
T10942	20803-20812	GO:0000239	denotes	pachynema
T10943	20838-20849	GO_EXT:killing	denotes	elimination
T10944	20862-20867	CL_GO_EXT:cell	denotes	cells
T11747	22332-22340	GO:0000238	denotes	zygotene
T11748	22341-22354	CL:0000017	denotes	spermatocytes
T11715	21690-21697	GO:0007126	denotes	Meiotic
T11716	21698-21706	GO:0051324	denotes	Prophase
T11717	21710-21715	PR_EXT:000006549	denotes	Dmrt7
T11718	21716-21722	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T11719	21723-21733	CL:0000586	denotes	Germ Cells
T11720	21728-21733	CL_GO_EXT:cell	denotes	Cells
T11721	21745-21755	GO_SO_EXT:chromosome	denotes	chromosome
T11722	21745-21763	GO:0007129	denotes	chromosome pairing
T11723	21765-21773	GO:0007129	denotes	synapsis
T11724	21778-21791	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T11725	21804-21813	GO:0000239	denotes	pachytene
T11726	21825-21834	GO:0006915	denotes	apoptosis
T11727	21879-21884	PR_EXT:000006549	denotes	Dmrt7
T11728	21885-21891	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T11729	21892-21898	UBERON:0000473	denotes	testes
T11730	21918-21926	GO:0007129	denotes	synapsis
T11731	21936-21946	GO:0042571	denotes	antibodies
T11732	21950-21955	PR_EXT:000015862	denotes	SYCP1
T11733	21959-21979	GO:0000795	denotes	synaptonemal complex
T11734	21980-21998	GO:0000802	denotes	transverse element
T11735	22014-22019	PR_EXT:000015865	denotes	SYCP3
T11736	22040-22053	GO:0000800	denotes	axial element
T11737	22078-22086	GO:0007129	denotes	synapsed
T11738	22099-22108	GO:0000240	denotes	diplonema
T11739	22118-22153	GO:0007130	denotes	Formation of synaptonemal complexes
T11740	22131-22153	GO:0000795	denotes	synaptonemal complexes
T11741	22161-22167	SO_EXT:sequence_altered_entity	denotes	mutant
T11742	22203-22212	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T11743	22257-22262	PR_EXT:000015862	denotes	SYCP1
T11744	22286-22291	PR_EXT:000015865	denotes	SYCP3
T11745	22319-22324	PR_EXT:000006549	denotes	Dmrt7
T11746	22325-22331	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T11749	22395-22408	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T11750	22395-22415	GO:0000725	denotes	recombination repair
T11751	22416-22422	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T11752	22423-22428	PR_EXT:000013672	denotes	RAD51
T11753	22452-22459	GO:0007126	denotes	meiotic
T11754	22460-22473	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T11755	22517-22522	PR_EXT:000006549	denotes	Dmrt7
T11756	22523-22529	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T11757	22530-22543	CL:0000017	denotes	spermatocytes
T11758	22594-22599	PR_EXT:000013672	denotes	RAD51
T11759	22625-22634	GO:0030849	denotes	autosomal
T11760	22635-22657	GO:0000795	denotes	synaptonemal complexes
T11761	22712-22717	CL_GO_EXT:cell	denotes	cells
T11762	22741-22750	GO:0000239	denotes	pachynema
T11763	22786-22794	GO:0007129	denotes	synapsis
T11764	22802-22811	GO:0000240	denotes	diplonema
T11765	22862-22873	GO_SO_EXT:chromosome	denotes	chromosomal
T11766	22862-22881	GO:0007129	denotes	chromosomal pairing
T11767	22883-22891	GO:0007129	denotes	synapsis
T11768	22893-22906	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T11769	22914-22922	GO:0007129	denotes	synapsis
T11770	22930-22940	GO:0007128	denotes	prophase I
T11771	22944-22949	PR_EXT:000006549	denotes	Dmrt7
T11772	22950-22956	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T11773	22957-22962	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T12957	23662-23670	CL_GO_EXT:cell	denotes	Cellular
T12958	23700-23713	CL:0000216	denotes	Sertoli Cells
T12959	23708-23713	CL_GO_EXT:cell	denotes	Cells
T12960	23714-23727	CL:0000216	denotes	Sertoli cells
T12961	23722-23727	CL_GO_EXT:cell	denotes	cells
T12962	23742-23752	CL:0000586	denotes	germ cells
T12963	23747-23752	CL_GO_EXT:cell	denotes	cells
T12964	23760-23775	GO:0007283	denotes	spermatogenesis
T12965	23812-23821	CL:0000586	denotes	germ cell
T12966	23817-23821	CL_GO_EXT:cell	denotes	cell
T12967	23817-23832	GO:0048469	denotes	cell maturation
T12968	23866-23871	PR_EXT:000006549	denotes	DMRT7
T12969	23872-23882	GO:0010467	denotes	expression
T12970	23886-23899	CL:0000216	denotes	Sertoli cells
T12971	23894-23899	CL_GO_EXT:cell	denotes	cells
T12972	23903-23911	GO:0042571	denotes	antibody
T12973	23970-23982	CL:0000216	denotes	Sertoli cell
T12974	23978-23982	CL_GO_EXT:cell	denotes	cell
T12975	24015-24019	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T12976	24050-24055	PR_EXT:000006549	denotes	Dmrt7
T12977	24056-24063	SO_EXT:sequence_altered_entity	denotes	mutants
T12978	24081-24093	CL:0000216	denotes	Sertoli cell
T12979	24089-24093	CL_GO_EXT:cell	denotes	cell
T12980	24089-24109	GO:0030154	denotes	cell differentiation
T12981	24123-24133	GO:0010467	denotes	expression
T12982	24141-24153	CL:0000216	denotes	Sertoli cell
T12983	24149-24153	CL_GO_EXT:cell	denotes	cell
T12984	24154-24161	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T12985	24162-24167	PR_EXT:000007859	denotes	GATA4
T12986	24171-24177	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T12987	24194-24199	GO:0007567	denotes	natal
T12988	24200-24213	CL:0000216	denotes	Sertoli cells
T12989	24208-24213	CL_GO_EXT:cell	denotes	cells
T12990	24219-24224	PR_EXT:000007857	denotes	GATA1
T12991	24235-24247	CL:0000216	denotes	Sertoli cell
T12992	24243-24247	CL_GO_EXT:cell	denotes	cell
T12993	24248-24254	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T12994	24277-24285	CHEBI_PR_EXT:protein	denotes	proteins
T12995	24314-24323	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T12996	24366-24374	CHEBI_EXT:50113	denotes	androgen
T12997	24366-24383	GO_PR_EXT:androgen_receptor	denotes	androgen receptor
T12998	24444-24457	CL:0000216	denotes	Sertoli cells
T12999	24452-24457	CL_GO_EXT:cell	denotes	cells
T13000	24461-24466	PR_EXT:000006549	denotes	Dmrt7
T13001	24467-24473	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T13002	24474-24480	UBERON:0000473	denotes	testes
T13003	24503-24510	UBERON:0000025	denotes	tubules
T13004	24511-24516	PR_EXT:000007857	denotes	GATA1
T13005	24526-24538	CL:0000216	denotes	Sertoli cell
T13006	24534-24545	GO:0005634	denotes	cell nuclei
T13007	24604-24621	GO_UBERON_EXT:basement_membrane	denotes	basement membrane
T13008	24643-24650	UBERON:0000025	denotes	tubules
T13009	24652-24661	_FRAGMENT	denotes	nuclei of
T13010	24679-24684	GO:0005634	denotes	cells
T13011	24666-24673	GO:0007126	denotes	meiotic
T13012	24674-24684	CL:0000586	denotes	germ cells
T13013	24689-24702	CL:0000017	denotes	spermatocytes
T13014	24728-24742	GO_UBERON_EXT:basement_membrane	denotes	basal membrane
T13015	24751-24761	CL:0000586	denotes	germ cells
T13016	24756-24761	CL_GO_EXT:cell	denotes	cells
T13017	25886-25898	CL:0000216	denotes	Sertoli cell
T13018	25894-25898	CL_GO_EXT:cell	denotes	cell
T13019	25915-25920	PR_EXT:000006549	denotes	Dmrt7
T13020	25921-25927	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T13021	25928-25934	UBERON:0000473	denotes	testes
T13022	25967-25976	CL:0000586	denotes	germ cell
T13023	25972-25976	CL_GO_EXT:cell	denotes	cell
T13024	26027-26039	CL:0000216	denotes	Sertoli cell
T13025	26035-26039	CL_GO_EXT:cell	denotes	cell
T13026	26079-26086	SO_EXT:sequence_deletion_process	denotes	deleted
T13027	26087-26092	PR_EXT:000006549	denotes	Dmrt7
T13028	26105-26117	CL:0000216	denotes	Sertoli cell
T13029	26113-26117	CL_GO_EXT:cell	denotes	cell
T13030	26138-26142	NCBITaxon:10088	denotes	mice
T13031	26156-26162	SO:0000359	denotes	floxed
T13032	26163-26168	PR_EXT:000006549	denotes	Dmrt7
T13033	26169-26175	SO_EXT:0001023	denotes	allele
T13034	26181-26184	PR_EXT:000006459	denotes	Dhh
T13035	26189-26199	SO_EXT:transgenic_entity	denotes	transgenic
T13036	26200-26204	NCBITaxon:10088	denotes	mice
T13037	26215-26230	PR_EXT:000006459	denotes	Desert hedgehog
T13038	26232-26235	PR_EXT:000006459	denotes	Dhh
T13039	26237-26245	SO_EXT:0000167	denotes	promoter
T13040	26287-26300	CL:0000216	denotes	Sertoli cells
T13041	26295-26300	CL_GO_EXT:cell	denotes	cells
T13042	26312-26322	CL:0000586	denotes	germ cells
T13043	26317-26322	CL_GO_EXT:cell	denotes	cells
T13044	26333-26341	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T13045	26345-26350	PR_EXT:000006549	denotes	Dmrt7
T13046	26354-26367	CL:0000216	denotes	Sertoli cells
T13047	26362-26367	CL_GO_EXT:cell	denotes	cells
T13048	26426-26436	UBERON:0000473	denotes	Testicular
T13049	26445-26452	CL:0000216	denotes	Sertoli
T13050	26463-26465	CL:0000216	denotes	SC
T13051	26475-26482	NCBITaxon:33208	denotes	animals
T13052	26517-26526	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T13053	26593-26602	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T13054	26607-26609	CL:0000216	denotes	SC
T13055	26618-26624	UBERON:0000473	denotes	testes
T13056	26638-26653	GO:0007283	denotes	Spermatogenesis
T13057	26678-26683	CL:0000019	denotes	sperm
T13058	26702-26704	CL:0000216	denotes	SC
T13059	26713-26717	NCBITaxon:10088	denotes	mice
T13060	26745-26750	PR_EXT:000007857	denotes	GATA1
T13061	26772-26784	CL:0000216	denotes	Sertoli cell
T13062	26780-26791	GO:0005634	denotes	cell nuclei
T13063	26821-26838	GO_UBERON_EXT:basement_membrane	denotes	basement membrane
T13064	26845-26854	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T13065	26894-26903	CL:0000586	denotes	germ cell
T13066	26899-26903	CL_GO_EXT:cell	denotes	cell
T13067	26915-26920	PR_EXT:000006549	denotes	Dmrt7
T13068	26921-26928	SO_EXT:sequence_altered_entity	denotes	mutants
T13069	26955-26960	PR_EXT:000006549	denotes	Dmrt7
T13070	26964-26977	CL:0000216	denotes	Sertoli cells
T13071	26972-26977	CL_GO_EXT:cell	denotes	cells
T13072	27016-27029	CL:0000216	denotes	Sertoli cells
T13073	27024-27029	CL_GO_EXT:cell	denotes	cells
T13074	27061-27066	PR_EXT:000006549	denotes	Dmrt7
T14566	27086-27095	GO:0001741	denotes	XY Bodies
T14567	27113-27118	PR_EXT:000006549	denotes	Dmrt7
T14568	27119-27125	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T14569	27126-27131	CL_GO_EXT:cell	denotes	Cells
T14570	27172-27177	PR_EXT:000006549	denotes	Dmrt7
T14571	27178-27184	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14572	27185-27195	CL:0000586	denotes	germ cells
T14573	27190-27195	CL_GO_EXT:cell	denotes	cells
T14574	27228-27235	GO:0007126	denotes	meiosis
T14575	27259-27268	GO:0000239	denotes	pachynema
T14576	27301-27306	PR_EXT:000006549	denotes	Dmrt7
T14577	27363-27370	GO:0007126	denotes	meiotic
T14578	27404-27411	GO:0007126	denotes	meiotic
T14579	27412-27422	CL:0000586	denotes	germ cells
T14580	27417-27422	CL_GO_EXT:cell	denotes	cells
T14581	27430-27436	SO_EXT:sequence_altered_entity	denotes	mutant
T14582	27456-27463	GO:0001741	denotes	XY body
T14583	27502-27509	GO:0007126	denotes	meiotic
T14584	27554-27559	PR_EXT:000006549	denotes	DMRT7
T14585	27560-27572	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T14586	27574-27589	_FRAGMENT	denotes	Condensation of
T14587	27602-27613	GO:0030261	denotes	chromosomes
T14588	27594-27595	_FRAGMENT	denotes	X
T14589	27602-27613	GO:0000805	denotes	chromosomes
T14590	27600-27613	GO:0000806	denotes	Y chromosomes
T14591	27602-27613	GO_SO_EXT:chromosome	denotes	chromosomes
T14592	27629-27637	GO:0000238	denotes	zygotene
T14593	27638-27643	CL_GO_EXT:cell	denotes	cells
T14594	27657-27666	GO:0000239	denotes	pachynema
T14595	27684-27694	GO_SO_EXT:chromosome	denotes	chromosome
T14596	27724-27737	GO:0001739	denotes	sex chromatin
T14597	27799-27816	GO:0034399	denotes	nuclear periphery
T14598	27846-27851	PR_EXT:000006549	denotes	DMRT7
T14599	27868-27875	GO:0001741	denotes	XY body
T14600	27923-27930	GO:0001741	denotes	XY body
T14601	27931-27940	GO:0000785	denotes	chromatin
T14602	27974-27984	GO:0010467	denotes	expression
T14603	28016-28020	PR_EXT:000008418	denotes	H2AX
T14604	28026-28033	SO_EXT:sequence_variant_entity	denotes	variant
T14605	28037-28040	PR_EXT:000027547	denotes	H2A
T14606	28061-28068	GO:0001741	denotes	XY body
T14607	28100-28109	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T14608	28126-28133	GO:0001741	denotes	XY body
T14609	28137-28142	PR_EXT:000006549	denotes	DMRT7
T14610	28143-28149	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14611	28150-28155	CL_GO_EXT:cell	denotes	cells
T14612	28159-28166	GO:0007126	denotes	meiotic
T14613	28235-28245	CL:0000586	denotes	germ cells
T14614	28240-28245	CL_GO_EXT:cell	denotes	cells
T14615	28249-28254	PR_EXT:000006549	denotes	Dmrt7
T14616	28255-28261	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14617	28262-28268	UBERON:0000473	denotes	testes
T14618	28300-28306	PR_EXT:000015829	denotes	SUMO-1
T14619	28307-28319	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T14620	28327-28333	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14621	28334-28340	UBERON:0000473	denotes	testis
T14622	28342-28348	PR_EXT:000015829	denotes	SUMO-1
T14623	28349-28359	GO:0010467	denotes	expression
T14624	28386-28393	GO:0001741	denotes	XY body
T14625	28411-28420	GO:0000239	denotes	pachytene
T14626	28421-28434	CL:0000017	denotes	spermatocytes
T14627	28450-28464	GO:0000803	denotes	sex chromosome
T14628	28454-28464	GO_SO_EXT:chromosome	denotes	chromosome
T14629	28454-28477	GO:0030261	denotes	chromosome condensation
T14630	28510-28532	GO:0007127	denotes	first meiotic division
T14631	28534-28540	PR_EXT:000015829	denotes	SUMO-1
T14632	28561-28568	GO:0001741	denotes	XY body
T14633	28576-28577	_FRAGMENT	denotes	X
T14634	28584-28595	GO:0000805	denotes	chromosomes
T14635	28582-28595	GO:0000806	denotes	Y chromosomes
T14636	28584-28595	GO_SO_EXT:chromosome	denotes	chromosomes
T14637	28598-28605	GO:0007129	denotes	synapse
T14638	28621-28627	PR_EXT:000015829	denotes	SUMO-1
T14639	28628-28640	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T14640	28656-28661	PR_EXT:000006549	denotes	Dmrt7
T14641	28662-28668	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14642	28669-28679	CL:0000586	denotes	germ cells
T14643	28674-28679	CL_GO_EXT:cell	denotes	cells
T14644	28728-28734	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marked
T14645	28735-28742	GO:0001741	denotes	XY body
T14646	28770-28777	UBERON:0000025	denotes	tubules
T14647	28781-28788	SO_EXT:sequence_altered_entity	denotes	mutants
T14648	28802-28817	UBERON:0000119	denotes	layers of cells
T14649	28812-28817	CL_GO_EXT:cell	denotes	cells
T14650	28823-28829	PR_EXT:000015829	denotes	SUMO-1
T14651	28889-28903	UBERON:0000119	denotes	layer of cells
T14652	28898-28903	CL_GO_EXT:cell	denotes	cells
T14653	28926-28933	GO:0001741	denotes	XY body
T14654	28945-28950	CL_GO_EXT:cell	denotes	cells
T14655	29038-29044	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14656	29045-29050	CL_GO_EXT:cell	denotes	cells
T14657	29067-29076	GO:0000239	denotes	pachytene
T14658	29095-29097	GO_PATO_EXT:ubiquitination_process_or_quality	denotes	Ub
T14659	29098-29101	PR_EXT:000027547	denotes	H2A
T14660	29102-29114	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T14661	29118-29123	PR_EXT:000006549	denotes	Dmrt7
T14662	29124-29130	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14663	29131-29137	UBERON:0000473	denotes	testes
T14664	29148-29157	GO:0000239	denotes	pachytene
T14665	29159-29161	GO_PATO_EXT:ubiquitination_process_or_quality	denotes	Ub
T14666	29162-29165	PR_EXT:000027547	denotes	H2A
T14667	29189-29196	GO:0001741	denotes	XY body
T14668	29205-29214	GO:0000239	denotes	pachytene
T14669	29215-29217	GO_PATO_EXT:ubiquitination_process_or_quality	denotes	Ub
T14670	29218-29221	PR_EXT:000027547	denotes	H2A
T14671	29256-29263	GO:0005634	denotes	nucleus
T14672	29301-29308	GO:0001741	denotes	XY body
T14673	29317-29326	GO:0000239	denotes	pachytene
T14674	29327-29340	CL:0000017	denotes	spermatocytes
T14675	29359-29366	GO:0005634	denotes	nuclear
T14676	29389-29391	GO_PATO_EXT:ubiquitination_process_or_quality	denotes	Ub
T14677	29392-29395	PR_EXT:000027547	denotes	H2A
T14678	29396-29405	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T14679	29422-29429	GO:0001741	denotes	XY body
T14680	29433-29438	PR_EXT:000006549	denotes	Dmrt7
T14681	29439-29446	SO_EXT:sequence_altered_entity	denotes	mutants
T14682	29502-29507	PR_EXT:000006549	denotes	Dmrt7
T14683	29508-29514	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T14684	29515-29525	CL:0000586	denotes	germ cells
T14685	29520-29525	CL_GO_EXT:cell	denotes	cells
T14686	29543-29550	GO:0001741	denotes	XY body
T14687	29584-29593	GO:0000785	denotes	chromatin
T14688	29594-29599	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marks
T17077	30116-30129	GO:0001739	denotes	Sex Chromatin
T17078	30133-30138	PR_EXT:000006549	denotes	Dmrt7
T17079	30139-30145	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T17080	30146-30156	CL:0000586	denotes	Germ Cells
T17081	30151-30156	CL_GO_EXT:cell	denotes	Cells
T17082	30170-30177	GO:0001741	denotes	XY body
T17083	30194-30203	GO:0000239	denotes	pachynema
T17084	30207-30212	PR_EXT:000006549	denotes	Dmrt7
T17085	30213-30220	SO_EXT:sequence_altered_entity	denotes	mutants
T17086	30257-30282	GO:0006342	denotes	transcriptional silencing
T17087	30352-30357	PR_EXT:000006549	denotes	Dmrt7
T17088	30369-30378	GO:0000239	denotes	pachytene
T17089	30379-30384	CL_GO_EXT:cell	denotes	cells
T17090	30420-30430	GO_EXT:killing	denotes	eliminated
T17091	30445-30454	GO:0000239	denotes	pachytene
T17092	30508-30518	GO:0007135	denotes	meiosis II
T17093	30523-30537	GO:0007286	denotes	spermiogenesis
T17094	30573-30582	GO:0000785	denotes	chromatin
T17095	30606-30613	GO:0007126	denotes	meiotic
T17096	30614-30627	GO:0001739	denotes	sex chromatin
T17097	30667-30676	GO:0000240	denotes	diplonema
T17098	30714-30723	GO:0000239	denotes	pachytene
T17099	30724-30733	CL:0000586	denotes	germ cell
T17100	30729-30733	CL_GO_EXT:cell	denotes	cell
T17101	30729-30739	GO:0008219	denotes	cell death
T17102	30743-30748	PR_EXT:000006549	denotes	Dmrt7
T17103	30749-30756	SO_EXT:sequence_altered_entity	denotes	mutants
T17104	30820-30834	GO:0000803	denotes	sex chromosome
T17105	30824-30834	GO_SO_EXT:chromosome	denotes	chromosome
T17106	30876-30885	GO:0000239	denotes	pachytene
T17107	30886-30893	GO:0001741	denotes	XY body
T17108	30909-30924	GO_EXT:transcription	denotes	transcriptional
T17109	30954-30957	CHEBI_SO_EXT:RNA	denotes	RNA
T17110	30979-30992	GO:0097617	denotes	hybridization
T17111	31018-31021	CHEBI_SO_EXT:RNA	denotes	RNA
T17112	31018-31035	GO_EXT:0001055	denotes	RNA polymerase II
T17113	31018-31049	GO:0006366	denotes	RNA polymerase II transcription
T17114	31065-31069	CHEBI:51231	denotes	DAPI
T17115	31093-31100	GO:0001741	denotes	XY body
T17116	31115-31135	UBERON:0001343	denotes	seminiferous tubules
T17117	31159-31164	PR_EXT:000006549	denotes	Dmrt7
T17118	31165-31172	SO_EXT:sequence_altered_entity	denotes	mutants
T17119	31178-31185	GO:0001741	denotes	XY body
T17120	31216-31229	GO:0097617	denotes	hybridization
T17121	31259-31284	GO:0006342	denotes	transcriptional silencing
T17122	31312-31318	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17123	31319-31328	GO:0000239	denotes	pachytene
T17124	31329-31334	CL_GO_EXT:cell	denotes	cells
T17125	31353-31363	GO:0010467	denotes	expression
T17126	31371-31372	GO:0000806	denotes	Y
T17127	31380-31384	SO_EXT:0000704	denotes	gene
T17128	31385-31389	PR_EXT:000030954	denotes	Rbmy
T17129	31428-31437	GO:0000239	denotes	pachytene
T17130	31460-31477	GO:0007135	denotes	secondary meiosis
T17131	31494-31498	PR_EXT:000030954	denotes	Rbmy
T17132	31527-31536	GO:0000239	denotes	pachytene
T17133	31537-31542	CL_GO_EXT:cell	denotes	cells
T17134	31546-31551	PR_EXT:000006549	denotes	Dmrt7
T17135	31552-31559	SO_EXT:sequence_altered_entity	denotes	mutants
T17136	31610-31614	PR_EXT:000030954	denotes	RBMY
T17137	31615-31623	GO:0042571	denotes	antibody
T17138	31654-31669	GO:0000792	denotes	heterochromatin
T17139	31654-31684	PR_EXT:000005082	denotes	heterochromatin protein 1 beta
T17140	31670-31677	CHEBI_PR_EXT:protein	denotes	protein
T17141	31686-31690	PR_EXT:000005082	denotes	HP1β
T17142	31708-31717	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T17143	31725-31726	GO:0000805	denotes	X
T17144	31727-31737	GO_SO_EXT:centromere_or_centromeric_region_or_centromeric_orientation	denotes	centromere
T17145	31745-31754	GO:0000239	denotes	pachynema
T17146	31784-31791	GO:0001741	denotes	XY body
T17147	31818-31827	GO:0000240	denotes	diplonema
T17148	31848-31852	PR_EXT:000005082	denotes	HP1β
T17149	31853-31865	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T17150	31879-31884	PR_EXT:000006549	denotes	DMRT7
T17151	31885-31891	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17152	31892-31897	CL_GO_EXT:cell	denotes	cells
T17153	31905-31914	GO:0000239	denotes	pachynema
T17154	31962-31969	GO:0001741	denotes	XY body
T17155	32026-32031	PR_EXT:000006549	denotes	Dmrt7
T17156	32032-32038	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17157	32039-32049	CL:0000586	denotes	germ cells
T17158	32044-32049	CL_GO_EXT:cell	denotes	cells
T17159	33375-33388	GO:0001739	denotes	sex chromatin
T17160	33433-33441	SO_EXT:sequence_alteration_process	denotes	modified
T17161	33445-33450	CL_GO_EXT:cell	denotes	cells
T17162	33456-33465	GO:0000239	denotes	pachynema
T17163	33504-33509	PR_EXT:000006549	denotes	Dmrt7
T17164	33510-33516	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17165	33517-33522	CL_GO_EXT:cell	denotes	cells
T17166	33527-33537	GO_EXT:killing	denotes	eliminated
T17167	33541-33550	GO:0006915	denotes	apoptosis
T17168	33560-33569	GO:0000240	denotes	diplonema
T17169	33595-33613	SO_EXT:epigenetic_modification_entity	denotes	epigenetic markers
T17170	33606-33613	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T17171	33630-33635	PR_EXT:000006549	denotes	Dmrt7
T17172	33636-33642	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17174	33670-33679	GO:0000239	denotes	pachytene
T17175	33707-33716	GO:0000240	denotes	diplonema
T17176	33745-33758	GO_EXT:transcription	denotes	transcription
T17177	33768-33781	GO:0097617	denotes	hybridization
T17178	33792-33807	GO:0000792	denotes	heterochromatic
T17179	33857-33868	GO:0000791	denotes	euchromatic
T17180	33905-33911	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17181	33912-33917	CL_GO_EXT:cell	denotes	cells
T17182	33922-33935	GO:0001739	denotes	sex chromatin
T17183	33964-33972	GO:0016458	denotes	silenced
T17184	33985-33994	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T17185	34031-34052	SO_EXT:epigenetic_modification_entity	denotes	epigenetic signatures
T17186	34062-34069	CHEBI:15358	denotes	histone
T17187	34062-34072	PR_EXT:000027594	denotes	histone H3
T17188	34075-34085	GO_MOP_EXT:methylation	denotes	methylated
T17189	34092-34102	GO_MOP_EXT:methylation	denotes	methylated
T17190	34106-34112	CHEBI_SO_EXT:lysine	denotes	lysine
T17191	34116-34118	PR_EXT:000027594	denotes	H3
T17192	34116-34124	SO_EXT:0001728	denotes	H3-2meK9
T17193	34126-34128	PR_EXT:000027594	denotes	H3
T17194	34126-34134	SO_EXT:0001707	denotes	H3-3meK9
T17195	34153-34157	PR_EXT:000005082	denotes	HP1β
T17196	34170-34177	GO:0001741	denotes	XY body
T17197	34248-34261	GO:0001739	denotes	sex chromatin
T17198	34262-34274	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T17199	34288-34295	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T17200	34299-34304	PR_EXT:000006549	denotes	Dmrt7
T17201	34305-34314	GO:0000240	denotes	diplotene
T17202	34315-34320	CL_GO_EXT:cell	denotes	cells
T17203	34331-34335	PR_EXT:000005082	denotes	HP1β
T17204	34336-34348	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T17205	34356-34368	GO:0000805	denotes	X chromosome
T17206	34358-34368	GO_SO_EXT:chromosome	denotes	chromosome
T17207	34369-34379	GO_SO_EXT:centromere_or_centromeric_region_or_centromeric_orientation	denotes	centromere
T17208	34413-34422	GO:0000239	denotes	pachynema
T17209	34436-34441	PR_EXT:000006549	denotes	Dmrt7
T17210	34442-34448	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17211	34449-34458	GO:0000240	denotes	diplotene
T17212	34459-34464	CL_GO_EXT:cell	denotes	cells
T17213	34498-34502	PR_EXT:000005082	denotes	HP1β
T17214	34517-34524	GO:0001741	denotes	XY body
T17215	34565-34570	PR_EXT:000006549	denotes	Dmrt7
T17216	34571-34577	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17217	34578-34587	GO:0000240	denotes	diplotene
T17218	34588-34593	CL_GO_EXT:cell	denotes	cells
T17219	34618-34620	PR_EXT:000027594	denotes	H3
T17220	34618-34626	SO_EXT:0001728	denotes	H3-2meK9
T17221	34631-34633	PR_EXT:000027594	denotes	H3
T17222	34631-34639	SO_EXT:0001707	denotes	H3-3meK9
T17223	34640-34645	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marks
T17224	34655-34668	GO:0001739	denotes	sex chromatin
T17225	34693-34698	PR_EXT:000006549	denotes	Dmrt7
T17226	34699-34705	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17227	34706-34715	GO:0000240	denotes	diplotene
T17228	34716-34721	CL_GO_EXT:cell	denotes	cells
T17229	34738-34750	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T17230	34754-34758	PR_EXT:000005082	denotes	HP1β
T17231	34766-34779	GO:0001739	denotes	sex chromatin
T17232	34818-34824	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17233	34825-34830	CL_GO_EXT:cell	denotes	cells
T17234	34834-34843	GO:0000240	denotes	diplonema
T17235	34851-34855	PR_EXT:000005082	denotes	HP1β
T17236	34863-34870	GO:0001741	denotes	XY body
T17237	34894-34903	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T17238	34904-34909	CL_GO_EXT:cell	denotes	cells
T17239	34935-34941	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17240	34942-34947	CL_GO_EXT:cell	denotes	cells
T17241	34960-34964	PR_EXT:000005082	denotes	HP1β
T17242	34996-35003	GO:0007126	denotes	meiosis
T17243	35035-35041	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17244	35042-35051	GO:0000240	denotes	diplotene
T17245	35052-35057	CL_GO_EXT:cell	denotes	cells
T17246	35075-35088	GO:0001739	denotes	sex chromatin
T17247	35107-35116	GO:0030849	denotes	autosomal
T17248	35151-35160	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T17249	35164-35181	CHEBI_SO_EXT:double_stranded_DNA	denotes	double-strand DNA
T17250	35182-35188	MOP:0000780	denotes	breaks
T17251	35230-35239	GO:0000240	denotes	diplotene
T17252	35240-35246	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17253	35247-35252	CL_GO_EXT:cell	denotes	cells
T17254	35281-35290	GO:0006915	denotes	apoptosis
T17255	35316-35329	GO:0001739	denotes	sex chromatin
T17256	35347-35356	GO:0000240	denotes	diplonema
T17257	35440-35445	CL_GO_EXT:cell	denotes	cells
T17258	35458-35468	GO_EXT:killing	denotes	eliminated
T17259	35510-35515	CL_GO_EXT:cell	denotes	cells
T17260	35525-35532	GO:0001741	denotes	XY body
T17261	35596-35602	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17262	35603-35608	CL_GO_EXT:cell	denotes	cells
T17263	35625-35631	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17264	35632-35637	CL_GO_EXT:cell	denotes	cells
T17265	35641-35651	GO_SO_EXT:chromosome	denotes	chromosome
T17266	35672-35680	GO:0042571	denotes	antibody
T17267	35684-35689	PR_EXT:000015865	denotes	SYCP3
T17268	35732-35737	PR_EXT:000006549	denotes	Dmrt7
T17269	35738-35744	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17270	35745-35754	GO:0000240	denotes	diplotene
T17271	35755-35760	CL_GO_EXT:cell	denotes	cells
T17272	35769-35773	PR_EXT:000005082	denotes	HP1β
T17273	35794-35801	GO:0001741	denotes	XY body
T17274	35874-35879	PR_EXT:000006549	denotes	Dmrt7
T17275	35880-35886	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T17276	35887-35892	CL_GO_EXT:cell	denotes	cells
T17277	35912-35919	GO:0001741	denotes	XY body
T17278	35927-35936	GO:0000239	denotes	pachynema
T17279	35961-35971	SO_EXT:epigenetic_modification_entity_or_process	denotes	epigenetic
T17280	35987-36000	GO:0001739	denotes	sex chromatin
T17281	35991-36011	GO:0016568	denotes	chromatin transition
T17282	36017-36026	GO:0000239	denotes	pachynema
T17283	36030-36039	GO:0000240	denotes	diplonema
T21143	36858-36863	CL_GO_EXT:cell	denotes	cells
T21144	36540-36546	SO_EXT:0000417	denotes	domain
T21145	36547-36554	CHEBI_PR_EXT:protein	denotes	protein
T21146	36555-36560	PR_EXT:000006549	denotes	DMRT7
T21147	36577-36581	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21148	36577-36592	CL:0000015	denotes	male germ cells
T21149	36587-36592	CL_GO_EXT:cell	denotes	cells
T21150	36605-36612	GO:0007126	denotes	meiotic
T21151	36613-36621	GO:0051324	denotes	prophase
T21152	36648-36654	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T21153	36669-36674	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T21154	36676-36681	PR_EXT:000006549	denotes	DMRT7
T21155	36682-36692	GO:0010467	denotes	expression
T21156	36707-36716	GO:0000239	denotes	pachytene
T21157	36717-36730	CL:0000017	denotes	spermatocytes
T21158	36740-36747	CHEBI_PR_EXT:protein	denotes	protein
T21159	36763-36772	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T21160	36780-36787	GO:0001741	denotes	XY body
T21161	36810-36820	GO:0010467	denotes	expression
T21162	36841-36847	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21163	36848-36852	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21164	36848-36863	CL:0000015	denotes	male germ cells
T21165	36874-36883	GO:0000239	denotes	pachynema
T21166	36896-36905	GO:0006915	denotes	apoptosis
T21167	36951-36960	GO:0000240	denotes	diplonema
T21168	36998-37007	GO:0000785	denotes	chromatin
T21169	37020-37033	GO_EXT:transcription	denotes	transcription
T21170	37037-37043	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21171	37044-37049	CL_GO_EXT:cell	denotes	cells
T21172	37069-37078	GO:0000240	denotes	diplonema
T21173	37088-37101	GO:0001739	denotes	sex chromatin
T21174	37141-37150	GO:0000239	denotes	pachytene
T21175	37160-37168	GO:0051324	denotes	prophase
T21176	37189-37200	GO_SO_EXT:chromosome	denotes	chromosomal
T21177	37232-37239	GO:0007129	denotes	synapse
T21178	37245-37254	GO_SO_EXT:sequence_rearrangement_process	denotes	recombine
T21179	37289-37311	GO:0051598	denotes	pachytene surveillance
T21180	37329-37336	GO:0065007	denotes	monitor
T21181	37351-37358	GO:0007126	denotes	meiotic
T21182	37372-37377	CL_GO_EXT:cell	denotes	Cells
T21183	37436-37446	GO_EXT:killing	denotes	eliminated
T21184	37450-37459	GO:0006915	denotes	apoptosis
T21185	37487-37496	GO:0000239	denotes	pachynema
T21186	37500-37504	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21187	37505-37512	NCBITaxon:40674	denotes	mammals
T21188	37537-37552	GO:0000803	denotes	sex chromosomes
T21189	37541-37552	GO_SO_EXT:chromosome	denotes	chromosomes
T21190	37562-37569	GO:0001741	denotes	XY body
T21191	37616-37620	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21192	37616-37628	GO:0007140	denotes	male meiosis
T21193	37636-37640	NCBITaxon:10088	denotes	mice
T21194	37645-37649	NCBITaxon:10088	denotes	mice
T21195	37661-37675	GO:0000803	denotes	sex-chromosome
T21196	37665-37675	GO_SO_EXT:chromosome	denotes	chromosome
T21197	37679-37687	GO:0030849	denotes	autosome
T21198	37688-37701	GO_EXT:biological_translocation_entity_or_process	denotes	translocation
T21199	37714-37719	CL_GO_EXT:cell	denotes	cells
T21200	37731-37745	GO:0000803	denotes	sex chromosome
T21201	37735-37745	GO_SO_EXT:chromosome	denotes	chromosome
T21202	37763-37773	GO_EXT:killing	denotes	eliminated
T21203	37788-37797	GO:0000239	denotes	pachynema
T21204	37869-37881	GO:0065007	denotes	surveillance
T21205	37904-37913	GO:0006915	denotes	apoptosis
T21206	37917-37922	PR_EXT:000006549	denotes	Dmrt7
T21207	37923-37929	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21208	37930-37943	CL:0000017	denotes	spermatocytes
T21209	37998-38007	GO:0000239	denotes	pachytene
T21210	38079-38085	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21211	38086-38091	CL_GO_EXT:cell	denotes	cells
T21212	38107-38118	GO_SO_EXT:chromosome	denotes	chromosomal
T21213	38107-38127	GO:0007129	denotes	chromosomal synapsis
T21214	38132-38145	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T21215	38163-38168	PR_EXT:000006549	denotes	Dmrt7
T21216	38169-38175	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21217	38176-38181	CL_GO_EXT:cell	denotes	cells
T21218	38211-38218	GO:0001741	denotes	XY body
T21219	38247-38252	PR_EXT:000006549	denotes	DMRT7
T21220	38296-38303	GO:0001741	denotes	XY body
T21221	38337-38342	PR_EXT:000006549	denotes	Dmrt7
T21222	38343-38349	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21223	38350-38355	CL_GO_EXT:cell	denotes	cells
T21224	38391-38396	CL_GO_EXT:cell	denotes	cells
T21225	38405-38412	GO:0001741	denotes	XY body
T21226	38471-38480	GO:0000785	denotes	chromatin
T21227	38481-38486	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marks
T21228	38516-38529	GO:0097617	denotes	hybridization
T21229	38546-38550	PR_EXT:000030954	denotes	RBMY
T21230	38551-38561	GO:0010467	denotes	expression
T21231	38611-38618	GO:0001741	denotes	XY body
T21232	38626-38635	GO:0000239	denotes	pachytene
T21233	38636-38641	PR_EXT:000006549	denotes	Dmrt7
T21234	38642-38648	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21235	38649-38654	CL_GO_EXT:cell	denotes	cells
T21236	38711-38724	GO:0001739	denotes	sex chromatin
T21237	38728-38733	PR_EXT:000006549	denotes	Dmrt7
T21238	38734-38740	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21239	38741-38751	CL:0000586	denotes	germ cells
T21240	38746-38751	CL_GO_EXT:cell	denotes	cells
T21241	38775-38784	GO:0000239	denotes	pachynema
T21242	38808-38817	GO:0000240	denotes	diplonema
T21243	38828-38833	CL_GO_EXT:cell	denotes	cells
T21244	38845-38847	PR_EXT:000027594	denotes	H3
T21245	38845-38853	SO_EXT:0001728	denotes	H3-2meK9
T21246	38858-38860	PR_EXT:000027594	denotes	H3
T21247	38858-38866	SO_EXT:0001707	denotes	H3-3meK9
T21248	38867-38872	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marks
T21249	38877-38881	PR_EXT:000005082	denotes	HP1β
T21250	38882-38889	CHEBI_PR_EXT:protein	denotes	protein
T21251	38897-38910	GO:0001739	denotes	sex chromatin
T21252	38931-38940	GO:0000240	denotes	diplonema
T21253	38958-38964	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21254	38965-38974	GO:0000240	denotes	diplotene
T21255	38975-38980	CL_GO_EXT:cell	denotes	cells
T21256	39034-39039	PR_EXT:000006549	denotes	Dmrt7
T21257	39040-39046	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21258	39047-39057	CL:0000586	denotes	germ cells
T21259	39052-39057	CL_GO_EXT:cell	denotes	cells
T21260	39076-39085	GO:0000239	denotes	pachynema
T21261	39089-39098	GO:0000240	denotes	diplonema
T21262	39121-39134	GO:0001739	denotes	sex chromatin
T21263	39125-39147	GO:0016568	denotes	chromatin modification
T21264	39135-39147	SO_EXT:sequence_alteration_entity_or_process	denotes	modification
T21265	39185-39189	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21266	39190-39203	GO:0001739	denotes	sex chromatin
T21267	39236-39241	PR_EXT:000006549	denotes	DMRT7
T21268	39258-39265	GO:0007126	denotes	meiosis
T21269	39279-39284	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T21270	39309-39316	NCBITaxon:40674	denotes	mammals
T21271	39334-39340	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21272	39341-39350	GO:0000240	denotes	diplotene
T21273	39351-39356	CL_GO_EXT:cell	denotes	cells
T21274	39380-39393	GO:0001739	denotes	sex chromatin
T21275	39447-39452	CL_GO_EXT:cell	denotes	cells
T21276	39478-39487	GO:0000240	denotes	diplonema
T21277	39502-39507	PR_EXT:000006549	denotes	Dmrt7
T21278	39508-39514	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21279	39515-39525	CL:0000586	denotes	germ cells
T21280	39520-39525	CL_GO_EXT:cell	denotes	cells
T21281	39530-39540	GO_EXT:killing	denotes	eliminated
T21282	39544-39553	GO:0006915	denotes	apoptosis
T21283	39591-39604	GO:0001739	denotes	sex chromatin
T21284	39641-39650	GO:0006915	denotes	apoptosis
T21285	39675-39688	GO:0001739	denotes	sex chromatin
T21286	39724-39737	GO:0001739	denotes	sex chromatin
T21287	39756-39765	GO:0006915	denotes	apoptosis
T21288	39820-39826	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21289	39827-39832	CL_GO_EXT:cell	denotes	cells
T21290	39838-39851	GO:0001739	denotes	sex chromatin
T21291	39882-39891	GO:0006915	denotes	apoptosis
T21292	39908-39917	GO:0006915	denotes	apoptosis
T21293	39931-39944	GO:0001739	denotes	sex chromatin
T21294	39984-39989	PR_EXT:000006549	denotes	Dmrt7
T21295	40069-40078	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T21296	40092-40097	PR_EXT:000006549	denotes	DMRT7
T21297	40117-40125	CHEBI_PR_EXT:protein	denotes	proteins
T21298	40170-40177	GO:0001741	denotes	XY body
T21299	40189-40196	PR_EXT:000043452	denotes	histone
T21300	40189-40196	CHEBI:15358	denotes	histone
T21301	40197-40205	SO_EXT:sequence_variant_entity	denotes	variants
T21302	40210-40218	SO_EXT:sequence_alteration_process	denotes	modified
T21303	40219-40227	PR_EXT:000043452	denotes	histones
T21304	40219-40227	CHEBI:15358	denotes	histones
T21305	40231-40237	UBERON:0000473	denotes	testis
T21306	40247-40254	PR_EXT:000043452	denotes	histone
T21307	40247-40254	CHEBI:15358	denotes	histone
T21308	40247-40273	GO_EXT:0042054	denotes	histone methyl transferase
T21309	40255-40261	CHEBI:32875	denotes	methyl
T21310	40285-40293	CHEBI_PR_EXT:protein	denotes	proteins
T21311	40298-40304	SO:0000910	denotes	orphan
T21312	40305-40313	GO_EXT:0004872	denotes	receptor
T21313	40314-40323	CL:0000586	denotes	germ-cell
T21314	40314-40338	PR_EXT:000011413	denotes	germ-cell nuclear factor
T21315	40319-40323	CL_GO_EXT:cell	denotes	cell
T21316	40324-40331	GO:0005634	denotes	nuclear
T21317	40344-40357	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T21318	40366-40374	CHEBI_PR_EXT:protein	denotes	proteins
T21319	40407-40415	CHEBI_PR_EXT:protein	denotes	proteins
T21320	40436-40451	GO:0000792	denotes	heterochromatin
T21321	40459-40474	GO_EXT:transcription	denotes	transcriptional
T21322	40487-40492	PR_EXT:000006549	denotes	DMRT7
T21323	40510-40517	GO:0001741	denotes	XY body
T21324	40518-40526	CHEBI_PR_EXT:protein	denotes	proteins
T21325	40568-40583	GO_EXT:transcription	denotes	transcriptional
T21326	40584-40594	GO_EXT:regulator	denotes	regulators
T21327	40630-40635	PR_EXT:000006549	denotes	DMRT7
T21328	40648-40656	SO_EXT:biological_sequence	denotes	sequence
T21329	40672-40682	GO_EXT:biological_recruitment	denotes	recruiting
T21330	40689-40697	CHEBI_PR_EXT:protein	denotes	proteins
T21331	40707-40716	GO:0000785	denotes	chromatin
T21332	40735-40742	GO:0001741	denotes	XY body
T21333	40778-40787	GO:0000785	denotes	Chromatin
T21334	40788-40798	GO:0065007	denotes	regulation
T21335	40832-40838	SO_EXT:0000417	denotes	domain
T21336	40839-40847	CHEBI_PR_EXT:protein	denotes	proteins
T21337	40874-40880	SO_EXT:0000417	denotes	domain
T21338	40881-40889	CHEBI_PR_EXT:protein	denotes	proteins
T21339	40905-40914	GO:0000785	denotes	chromatin
T21340	40905-40924	GO:0016568	denotes	chromatin modifying
T21341	40915-40924	SO_EXT:sequence_alteration_process	denotes	modifying
T21342	40925-40934	GO:0032991	denotes	complexes
T21343	41019-41024	PR_EXT:000006549	denotes	Dmrt7
T21344	41042-41051	NCBITaxon:40674	denotes	mammalian
T21345	41052-41059	GO:0007126	denotes	meiosis
T21346	41096-41100	SO_EXT:0000704	denotes	gene
T21347	41109-41121	NCBITaxon_EXT:invertebrate	denotes	Invertebrate
T21348	41125-41131	SO_EXT:0000417	denotes	domain
T21349	41132-41137	SO_EXT:0000704	denotes	genes
T21350	41181-41194	CL:0002371	denotes	somatic cells
T21351	41189-41194	CL_GO_EXT:cell	denotes	cells
T21352	41209-41215	SO_EXT:0000417	denotes	domain
T21353	41216-41221	SO_EXT:0000704	denotes	genes
T21354	41223-41228	PR_EXT:000006542	denotes	Dmrt1
T21355	41233-41238	PR_EXT:000006545	denotes	Dmrt4
T21356	41250-41259	CL:0000586	denotes	germ cell
T21357	41250-41271	GO:0007281	denotes	germ cell development
T21358	41255-41259	CL_GO_EXT:cell	denotes	cell
T21359	41279-41284	NCBITaxon:10088	denotes	mouse
T21360	41286-41291	PR_EXT:000006542	denotes	Dmrt1
T21361	41311-41318	GO:0007126	denotes	meiotic
T21362	41319-41323	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21363	41319-41334	CL:0000015	denotes	male germ cells
T21364	41329-41334	CL_GO_EXT:cell	denotes	cells
T21365	41339-41354	GO:0030154	denotes	differentiation
T21366	41358-41367	CL:0000670	denotes	gonocytes
T21367	41373-41386	CL:0000020	denotes	spermatogonia
T21368	41402-41415	CL:0000216	denotes	Sertoli cells
T21369	41410-41415	CL_GO_EXT:cell	denotes	cells
T21370	41431-41440	GO:0010467	denotes	expressed
T21371	41444-41451	GO:0007126	denotes	meiotic
T21372	41452-41457	CL_GO_EXT:cell	denotes	cells
T21373	41527-41532	PR_EXT:000006542	denotes	DMRT1
T21374	41540-41547	GO:0007126	denotes	meiotic
T21375	41548-41558	CL:0000586	denotes	germ cells
T21376	41553-41558	CL_GO_EXT:cell	denotes	cells
T21377	41563-41568	PR_EXT:000006549	denotes	DMRT7
T21378	41572-41579	GO:0007126	denotes	meiotic
T21379	41580-41590	CL:0000586	denotes	germ cells
T21380	41585-41590	CL_GO_EXT:cell	denotes	cells
T21381	41612-41618	SO_EXT:0000417	denotes	domain
T21382	41619-41627	CHEBI_PR_EXT:protein	denotes	proteins
T21383	41663-41667	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21384	41663-41677	CL:0000015	denotes	male germ cell
T21385	41668-41689	GO:0007281	denotes	germ cell development
T21386	41673-41677	CL_GO_EXT:cell	denotes	cell
T21387	41691-41698	UBERON:0000992	denotes	Ovaries
T21388	41702-41707	PR_EXT:000006545	denotes	Dmrt4
T21389	41708-41714	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21390	41715-41722	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T21391	41732-41738	CL:0000025	denotes	ovular
T21392	41739-41748	UBERON_EXT:follicle	denotes	follicles
T21393	41750-41759	UBERON_EXT:follicle	denotes	follicles
T21394	41780-41787	CL:0000023	denotes	oocytes
T21395	41903-41912	NCBITaxon:40674	denotes	mammalian
T21396	41916-41922	SO_EXT:0000417	denotes	domain
T21397	41923-41928	SO_EXT:0000704	denotes	genes
T21398	41936-41943	UBERON:0000991	denotes	gonadal
T21399	41936-41955	GO:0008406	denotes	gonadal development
T21400	42008-42016	CHEBI_PR_EXT:protein	denotes	proteins
T21401	42020-42029	GO_EXT:biological_direction_or_guidance	denotes	directing
T21402	42030-42062	GO:0007546	denotes	sex-specific somatic development
T21403	42072-42077	NCBITaxon:phylum	denotes	phyla
T21404	42091-42096	PR_EXT:000006549	denotes	Dmrt7
T21405	42121-42130	UBERON:0001987	denotes	placental
T21406	42121-42138	NCBITaxon:9347	denotes	placental mammals
T21407	42152-42162	NCBITaxon:9263	denotes	marsupials
T21408	42169-42178	NCBITaxon:9255	denotes	monotreme
T21409	42180-42183	UBERON:0007379	denotes	egg
T21410	42180-42197	NCBITaxon:9255	denotes	egg-laying mammal
T21411	42204-42212	NCBITaxon:9258	denotes	platypus
T21412	42232-42237	PR_EXT:000006549	denotes	Dmrt7
T21413	42238-42246	SO_EXT:0000855	denotes	ortholog
T21414	42271-42276	PR_EXT:000006549	denotes	Dmrt7
T21415	42277-42285	SO_EXT:0000855	denotes	ortholog
T21416	42310-42319	NCBITaxon:40674	denotes	mammalian
T21417	42320-42331	NCBITaxon:7742	denotes	vertebrates
T21418	42385-42390	PR_EXT:000006549	denotes	Dmrt7
T21419	42419-42430	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T21420	42462-42466	SO_EXT:0000704	denotes	gene
T21421	42506-42515	NCBITaxon:40674	denotes	mammalian
T21422	42527-42537	NCBITaxon:9255	denotes	Monotremes
T21423	42548-42549	_FRAGMENT	denotes	X
T21424	42561-42572	GO:0000805	denotes	chromosomes
T21425	42559-42572	GO:0000806	denotes	Y chromosomes
T21426	42561-42572	GO_SO_EXT:chromosome	denotes	chromosomes
T21427	42618-42625	GO:0007126	denotes	meiosis
T21428	42654-42669	GO:0000803	denotes	sex chromosomes
T21429	42658-42669	GO_SO_EXT:chromosome	denotes	chromosomes
T21430	42683-42690	NCBITaxon:40674	denotes	mammals
T21431	42713-42718	PR_EXT:000006549	denotes	Dmrt7
T21432	42779-42794	GO:0000803	denotes	sex chromosomes
T21433	42783-42794	GO_SO_EXT:chromosome	denotes	chromosomes
T21434	42802-42815	GO:0001739	denotes	sex chromatin
T21435	42819-42829	NCBITaxon:9255	denotes	monotremes
T21436	42840-42847	NCBITaxon:40674	denotes	mammals
T21437	42875-42880	PR_EXT:000006549	denotes	Dmrt7
T21438	42917-42926	NCBITaxon:40674	denotes	mammalian
T21439	42927-42944	GO:0007530	denotes	sex determination
T21440	42988-42992	SO_EXT:0000704	denotes	gene
T21441	43001-43011	GO_SO_EXT:chromosome	denotes	chromosome
T21442	43001-43019	GO:0007129	denotes	chromosome pairing
T21443	43021-43034	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T21444	43045-43052	GO:0007126	denotes	meiotic
T21445	43073-43087	GO:0000803	denotes	sex chromosome
T21446	43077-43087	GO_SO_EXT:chromosome	denotes	chromosome
T21447	43140-43151	GO_EXT:biological_recruitment	denotes	recruitment
T21448	43155-43160	PR_EXT:000006549	denotes	Dmrt7
T21449	43168-43177	NCBITaxon:40674	denotes	mammalian
T21450	43212-43223	GO_EXT:biological_recruitment	denotes	recruitment
T21451	43227-43236	GO:0000785	denotes	chromatin
T21452	43237-43247	GO:0065007	denotes	regulatory
T21453	43248-43257	GO:0032991	denotes	complexes
T21454	43277-43296	GO:0007549	denotes	dosage compensation
T21455	43331-43346	GO:0000803	denotes	sex chromosomes
T21456	43335-43346	GO_SO_EXT:chromosome	denotes	chromosomes
T21457	43358-43363	NCBITaxon:phylum	denotes	phyla
T21458	43428-43433	PR_EXT:000006549	denotes	DMRT7
T21459	43434-43443	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T21460	43447-43462	GO:0000803	denotes	sex chromosomes
T21461	43451-43462	GO_SO_EXT:chromosome	denotes	chromosomes
T21462	43470-43479	NCBITaxon:9255	denotes	monotreme
T21463	43480-43487	GO:0007126	denotes	meiosis
T21464	43524-43530	NCBITaxon:40674	denotes	mammal
T21465	43543-43549	SO_EXT:0000417	denotes	domain
T21466	43550-43557	CHEBI_PR_EXT:protein	denotes	protein
T21467	43558-43563	PR_EXT:000006549	denotes	DMRT7
T21468	43581-43588	GO:0007126	denotes	meiotic
T21469	43589-43597	GO:0051324	denotes	prophase
T21470	43613-43618	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T21471	43620-43625	PR_EXT:000006549	denotes	DMRT7
T21472	43626-43635	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T21473	43643-43658	GO:0000803	denotes	sex chromosomes
T21474	43647-43658	GO_SO_EXT:chromosome	denotes	chromosomes
T21475	43701-43716	GO:0000792	denotes	heterochromatin
T21476	43727-43732	PR_EXT:000006549	denotes	Dmrt7
T21477	43733-43739	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T21478	43740-43745	CL_GO_EXT:cell	denotes	cells
T21479	43751-43761	SO_EXT:epigenetic_modification_entity_or_process	denotes	epigenetic
T21480	43777-43789	SO_EXT:sequence_alteration_entity_or_process	denotes	modification
T21481	43777-43792	_FRAGMENT	denotes	modification of
T21482	43801-43810	GO:0016568	denotes	chromatin
T21483	43797-43810	GO:0001739	denotes	sex chromatin
T21484	43819-43828	GO:0000239	denotes	pachytene
T21485	43833-43842	GO:0000240	denotes	diplotene
T21486	43853-43858	PR_EXT:000006549	denotes	Dmrt7
T21487	43885-43894	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T21488	43895-43899	SO_EXT:0000704	denotes	gene
T21489	43928-43935	NCBITaxon:40674	denotes	mammals
T21490	43958-43963	PR_EXT:000006549	denotes	DMRT7
T21491	43989-43995	NCBITaxon:40674	denotes	mammal
T21492	44005-44012	CHEBI_PR_EXT:protein	denotes	protein
T21493	44035-44042	GO:0007126	denotes	meiosis
T21494	44109-44114	PR_EXT:000006549	denotes	DMRT7
T21495	44123-44136	GO:0001739	denotes	sex chromatin
T21496	44137-44147	GO:0065007	denotes	regulation
T21497	44155-44159	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21498	44155-44167	GO:0007140	denotes	male meiosis
T23703	44623-44629	SO_EXT:0000440	denotes	vector
T23779	46043-46049	SO:0000359	denotes	floxed
T23686	44207-44212	PR_EXT:000006549	denotes	Dmrt7
T23687	44213-44217	NCBITaxon:10088	denotes	mice
T23688	44221-44226	NCBITaxon:10088	denotes	mouse
T23689	44227-44232	PR_EXT:000006549	denotes	Dmrt7
T23690	44233-44237	SO_EXT:cDNA	denotes	cDNA
T23691	44258-44267	SO_EXT:biological_sequence	denotes	sequences
T23692	44273-44277	SO_EXT:0000147	denotes	exon
T23693	44301-44306	NCBITaxon:10088	denotes	mouse
T23694	44307-44310	SO_EXT:0000153	denotes	BAC
T23695	44388-44394	SO_EXT:sequence_cloned_entity	denotes	clones
T23696	44406-44414	SO_EXT:0000167	denotes	promoter
T23697	44415-44424	SO_EXT:biological_sequence	denotes	sequences
T23698	44463-44468	PR_EXT:000006549	denotes	Dmrt7
T23699	44469-44476	SO_EXT:0001026	denotes	genomic
T23700	44477-44485	SO_EXT:biological_sequence	denotes	sequence
T23701	44491-44507	SO_EXT:0001644	denotes	targeting vector
T23702	44586-44592	SO_EXT:0000440	denotes	vector
T23704	44642-44645	GO_EXT:phosphoglycerate_kinase	denotes	Pgk
T23705	44646-44649	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T23706	44658-44667	SO_EXT:0000346	denotes	loxP site
T23707	44672-44680	SO_EXT:sequence_insertion_process	denotes	inserted
T23708	44697-44700	CHEBI_SO_EXT:DNA	denotes	DNA
T23709	44721-44727	SO_EXT:0000188	denotes	intron
T23710	44731-44736	PR_EXT:000006549	denotes	Dmrt7
T23711	44747-44749	SO_EXT:0000028	denotes	bp
T23712	44759-44761	SO_EXT:0000028	denotes	bp
T23713	44762-44772	SO_EXT:sequence_downstreamness	denotes	downstream
T23714	44776-44780	SO_EXT:0000147	denotes	exon
T23715	44808-44811	GO_EXT:phosphoglycerate_kinase	denotes	Pgk
T23716	44812-44815	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T23717	44820-44828	SO_EXT:sequence_insertion_process	denotes	inserted
T23718	44877-44879	SO_EXT:0000028	denotes	bp
T23719	44887-44889	SO_EXT:0000028	denotes	bp
T23720	44900-44905	PR_EXT:000006549	denotes	Dmrt7
T23721	44906-44925	GO_SO_EXT:translational_start_entity_or_process	denotes	translational start
T23722	44939-44947	SO_EXT:sequence_insertion_process	denotes	inserted
T23723	44950-44959	SO_EXT:0000346	denotes	loxP site
T23724	44969-44973	SO_EXT:0000061	denotes	site
T23725	44978-44980	SO_EXT:0000028	denotes	bp
T23726	44991-44996	PR_EXT:000006549	denotes	Dmrt7
T23727	44997-45016	GO_SO_EXT:translational_start_entity_or_process	denotes	translational start
T23728	45035-45041	SO_EXT:0000440	denotes	vector
T23729	45064-45069	SO_EXT:0000147	denotes	exons
T23730	45073-45078	PR_EXT:000006549	denotes	Dmrt7
T23731	45083-45090	SO:0000357	denotes	flanked
T23732	45094-45104	SO_EXT:0000346	denotes	loxP sites
T23733	45106-45112	SO:0000359	denotes	floxed
T23734	45119-45124	PR_EXT:000006549	denotes	Dmrt7
T23735	45193-45203	SO_EXT:sequence_linearization	denotes	linearized
T23736	45242-45250	CL:0002322	denotes	ES cells
T23737	45245-45250	CL_GO_EXT:cell	denotes	cells
T23738	45312-45324	SO_EXT:sequence_recombinant_entity	denotes	recombinants
T23739	45350-45354	CHEBI:42768	denotes	G418
T23740	45386-45399	GO:0097617	denotes	hybridization
T23741	45412-45415	CHEBI_SO_EXT:DNA	denotes	DNA
T23742	45416-45421	CHEBI_SO_EXT:molecular_probe	denotes	probe
T23743	45431-45440	SO_EXT:biological_sequence	denotes	sequences
T23744	45441-45449	SO_EXT:sequence_upstreamness	denotes	upstream
T23745	45453-45457	SO_EXT:0000147	denotes	exon
T23746	45470-45481	SO_EXT:genomic_DNA	denotes	genomic DNA
T23747	45478-45481	CHEBI_SO_EXT:DNA	denotes	DNA
T23748	45514-45527	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T23749	45590-45603	GO:0097617	denotes	hybridization
T23750	45605-45611	CHEBI_SO_EXT:molecular_probe	denotes	Probes
T23751	45625-45638	GO:0097617	denotes	hybridization
T23752	45662-45669	SO_EXT:0000112	denotes	primers
T23753	45688-45693	CHEBI_SO_EXT:molecular_probe	denotes	probe
T23754	45717-45722	CHEBI_SO_EXT:molecular_probe	denotes	probe
T23755	45752-45759	CL:0002322	denotes	ES cell
T23756	45755-45759	CL_GO_EXT:cell	denotes	cell
T23757	45760-45766	SO_EXT:sequence_cloned_entity	denotes	clones
T23758	45782-45788	SO:0000359	denotes	floxed
T23759	45789-45795	SO_EXT:0001023	denotes	allele
T23760	45796-45801	PR_EXT:000006549	denotes	Dmrt7
T23761	45801-45804	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T23762	45832-45843	UBERON:0000358	denotes	blastocysts
T23763	45875-45880	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T23764	45886-45890	GO_EXT:breeding	denotes	bred
T23765	45904-45911	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T23766	45947-45952	PR_EXT:000006549	denotes	Dmrt7
T23767	45952-45955	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T23768	45957-45962	PR_EXT:000006549	denotes	Dmrt7
T23769	45962-45963	SO_EXT:normal_or_wild_type_or_present	denotes	+
T23770	45964-45969	PR_EXT:000006549	denotes	Dmrt7
T23771	45969-45972	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T23772	45973-45980	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T23773	45986-45990	GO_EXT:breeding	denotes	bred
T23774	45996-46000	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T23775	46001-46008	PR_EXT:000003676	denotes	β-actin
T23776	46013-46023	SO_EXT:transgenic_entity	denotes	transgenic
T23777	46024-46028	NCBITaxon:10088	denotes	mice
T23778	46032-46038	SO_EXT:sequence_deletion_process	denotes	delete
T23780	46050-46059	SO_EXT:biological_sequence	denotes	sequences
T23781	46086-46091	PR_EXT:000006549	denotes	Dmrt7
T23782	46091-46092	SO_EXT:sequence_nullness_or_absence	denotes	−
T23783	46094-46095	SO_EXT:normal_or_wild_type_or_present	denotes	+
T23784	46096-46104	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T23785	46105-46112	SO_EXT:sequence_altered_entity	denotes	mutants
T23786	46130-46134	GO_EXT:breeding	denotes	bred
T23787	46158-46163	PR_EXT:000006549	denotes	Dmrt7
T23788	46163-46164	SO_EXT:sequence_nullness_or_absence	denotes	−
T23789	46165-46166	SO_EXT:sequence_nullness_or_absence	denotes	−
T23790	46167-46174	SO_EXT:sequence_altered_entity	denotes	mutants
T24458	46192-46194	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T24459	46216-46220	UBERON:0002415	denotes	tail
T24460	46226-46229	CHEBI_SO_EXT:DNA	denotes	DNA
T24461	46259-46270	GO_SO_EXT:chromosome	denotes	Chromosomal
T24462	46302-46309	SO_EXT:0000112	denotes	primers
T24463	46317-46329	GO:0000806	denotes	Y chromosome
T24464	46319-46329	GO_SO_EXT:chromosome	denotes	chromosome
T24465	46330-46334	SO_EXT:0000704	denotes	gene
T24466	46335-46338	PR_EXT:000017657	denotes	Zfy
T24467	46352-46361	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T24468	46362-46367	PR_EXT:000006549	denotes	Dmrt7
T24469	46368-46374	SO_EXT:0001023	denotes	allele
T24470	46375-46380	PR_EXT:000006549	denotes	Dmrt7
T24471	46428-46437	GO:0097617	denotes	annealing
T24472	46464-46469	PR_EXT:000006549	denotes	Dmrt7
T24473	46469-46473	SO:0000359	denotes	flox
T24474	46474-46480	SO_EXT:0001023	denotes	allele
T24475	46529-46538	GO:0097617	denotes	annealing
T24476	46565-46572	SO_EXT:sequence_deletion_process	denotes	deleted
T24477	46573-46578	PR_EXT:000006549	denotes	Dmrt7
T24478	46579-46585	SO_EXT:0001023	denotes	allele
T24479	46586-46591	PR_EXT:000006549	denotes	Dmrt7
T24480	46633-46642	GO:0097617	denotes	annealing
T24481	46665-46667	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T24482	46676-46681	PR_EXT:000006549	denotes	Dmrt7
T24483	46682-46692	GO:0010467	denotes	expression
T24484	46730-46737	SO_EXT:0000112	denotes	primers
T24485	46758-46767	GO:0097617	denotes	annealing
T24839	46791-46798	SO_EXT:0000112	denotes	Primers
T25208	47426-47432	UBERON:0000473	denotes	testes
T25209	47455-47463	CHEBI_EXT:50913	denotes	fixative
T25210	47467-47476	CHEBI_EXT:phosphate	denotes	phosphate
T25211	47477-47485	CHEBI_CHMO_EXT:buffer_process	denotes	buffered
T25212	47486-47494	CHEBI:16842	denotes	formalin
T25213	47551-47558	CHEBI:16236	denotes	ethanol
T25214	47592-47595	CHEBI:73702	denotes	wax
T25215	47663-47674	CHEBI:51686	denotes	hematoxylin
T25216	47679-47684	CHEBI_EXT:eosin	denotes	eosin
T25217	47748-47758	GO_EXT:0008233	denotes	proteinase
T25218	47793-47810	CHEBI:16240	denotes	hydrogen peroxide
T25219	47863-47870	GO:0005634	denotes	nuclear
T25220	47883-47892	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T25221	47883-47898	CL:0000445	denotes	apoptotic cells
T25222	47893-47898	CL_GO_EXT:cell	denotes	cells
T25487	48013-48019	UBERON:0000479	denotes	Tissue
T25488	48103-48111	CHEBI:53424	denotes	Tween 20
T25489	48144-48155	CHEBI:30769	denotes	citric acid
T25490	48217-48222	UBERON:0001977	denotes	serum
T25491	48264-48272	GO:0042571	denotes	antibody
T25492	48336-48346	GO:0042571	denotes	antibodies
T25493	48399-48409	GO:0042571	denotes	antibodies
T26404	48412-48422	GO:0042571	denotes	Antibodies
T26405	48424-48430	NCBITaxon:9986	denotes	Rabbit
T26406	48442-48452	GO:0042571	denotes	antibodies
T26407	48456-48461	PR_EXT:000006549	denotes	DMRT7
T26408	48493-48499	SO_EXT:sequence_fusion_entity_or_process	denotes	fusion
T26409	48500-48507	CHEBI_PR_EXT:protein	denotes	protein
T26410	48519-48530	CHEBI:16856	denotes	glutathione
T26411	48519-48544	GO_PR_EXT:glutathione_S_transferase	denotes	glutathione-S-transferase
T26412	48531-48532	CHEBI_EXT:sulfur	denotes	S
T26413	48546-48549	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T26414	48551-48556	SO_EXT:sequence_fusion_process	denotes	fused
T26415	48564-48574	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T26416	48579-48590	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T26417	48594-48599	PR_EXT:000006549	denotes	DMRT7
T26418	48601-48611	GO:0042571	denotes	Antibodies
T26419	48615-48618	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T26420	48635-48638	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T26421	48677-48682	UBERON:0001977	denotes	serum
T26422	48704-48707	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T26423	48708-48713	PR_EXT:000006549	denotes	DMRT7
T26424	48741-48746	PR_EXT:000006549	denotes	DMRT7
T26425	48747-48755	GO:0042571	denotes	antibody
T26426	48790-48794	NCBITaxon:9925	denotes	goat
T26427	48800-48806	NCBITaxon:9986	denotes	rabbit
T26428	48817-48825	GO:0042571	denotes	antibody
T26429	48827-48836	CHEBI_EXT:polyatomic_entity_or_group	denotes	Molecular
T26430	48837-48843	CHEBI_SO_EXT:molecular_probe	denotes	Probes
T26431	48905-48915	GO:0042571	denotes	antibodies
T26432	48949-48952	NCBITaxon:10114	denotes	rat
T26433	48958-48963	PR_EXT:000007857	denotes	GATA1
T26434	49028-49032	NCBITaxon:9925	denotes	goat
T26435	49038-49043	PR_EXT:000007859	denotes	GATA4
T26436	49088-49091	NCBITaxon:10114	denotes	rat
T26437	49148-49151	NCBITaxon:10114	denotes	rat
T26438	49205-49208	NCBITaxon:10114	denotes	rat
T26439	49266-49272	NCBITaxon:9986	denotes	rabbit
T26440	49278-49283	PR_EXT:000013672	denotes	RAD51
T26441	49338-49343	NCBITaxon:10088	denotes	mouse
T26442	49349-49354	PR_EXT:000015829	denotes	GMP-1
T26443	49355-49361	PR_EXT:000015829	denotes	SUMO-1
T26444	49410-49416	NCBITaxon:9986	denotes	rabbit
T26445	49422-49429	CHEBI:32958	denotes	phospho
T26446	49430-49434	PR_EXT:000008418	denotes	H2AX
T26447	49496-49501	NCBITaxon:10088	denotes	mouse
T26448	49507-49514	CHEBI:32958	denotes	phospho
T26449	49515-49519	PR_EXT:000008418	denotes	H2AX
T26450	49546-49551	NCBITaxon:10088	denotes	mouse
T26451	49557-49562	PR_EXT:000015865	denotes	SYCP3
T26452	49610-49616	NCBITaxon:9986	denotes	rabbit
T26453	49622-49626	PR_EXT:000005082	denotes	HP1β
T26454	49652-49658	NCBITaxon:9986	denotes	rabbit
T26455	49664-49666	PR_EXT:000027594	denotes	H3
T26456	49664-49672	SO_EXT:0001728	denotes	H3-2meK9
T26457	49699-49705	NCBITaxon:9986	denotes	rabbit
T26458	49711-49713	PR_EXT:000027594	denotes	H3
T26459	49711-49719	SO_EXT:0001707	denotes	H3-3meK9
T26460	49746-49752	NCBITaxon:9986	denotes	rabbit
T26461	49758-49760	GO_PR_EXT:androgen_receptor	denotes	AR
T26462	49815-49820	NCBITaxon:10088	denotes	mouse
T26463	49826-49830	PR_EXT:000003675	denotes	αSMA
T26464	49831-49836	SO_EXT:sequence_cloned_entity	denotes	clone
T26465	49903-49913	GO:0042571	denotes	antibodies
T26466	49924-49928	NCBITaxon:9925	denotes	goat
T26467	49934-49940	NCBITaxon:9986	denotes	rabbit
T26468	49941-49950	CHEBI:52661	denotes	Alexa 488
T26469	49952-49956	NCBITaxon:9925	denotes	goat
T26470	49962-49968	NCBITaxon:9986	denotes	rabbit
T26471	49969-49978	CHEBI:51248	denotes	Alexa 594
T26472	49980-49984	NCBITaxon:9925	denotes	goat
T26473	49990-49993	NCBITaxon:10114	denotes	rat
T26474	49994-50003	CHEBI:51248	denotes	Alexa 594
T26475	50009-50013	NCBITaxon:9925	denotes	goat
T26476	50019-50024	NCBITaxon:10088	denotes	mouse
T26477	50025-50034	CHEBI:52661	denotes	Alexa 488
T26478	50036-50045	CHEBI_EXT:polyatomic_entity_or_group	denotes	Molecular
T26479	50046-50052	CHEBI_SO_EXT:molecular_probe	denotes	Probes
T26480	50069-50075	NCBITaxon:9793	denotes	Donkey
T26481	50081-50085	NCBITaxon:9925	denotes	goat
T26482	50086-50090	CHEBI:37926	denotes	FITC
T26483	50163-50169	NCBITaxon:9793	denotes	donkey
T26484	50175-50181	NCBITaxon:9986	denotes	rabbit
T26485	50182-50191	CHEBI:51247	denotes	Texas Red
T27164	50267-50274	GO:0007126	denotes	Meiotic
T27165	50275-50285	GO_SO_EXT:chromosome	denotes	chromosome
T27166	50316-50323	GO:0007126	denotes	Meiotic
T27167	50324-50334	GO_SO_EXT:chromosome	denotes	chromosome
T27168	50379-50383	NCBITaxon:10088	denotes	mice
T27169	50464-50467	CHEBI_SO_EXT:RNA	denotes	RNA
T27170	50474-50481	GO:0007126	denotes	meiotic
T27171	50551-50561	GO_SO_EXT:chromosome	denotes	chromosome
T27172	50573-50580	GO:0007126	denotes	meiotic
T27173	50581-50594	CL:0000017	denotes	spermatocytes
T27174	50643-50646	CHEBI_SO_EXT:RNA	denotes	RNA
T27175	50699-50702	CHEBI_SO_EXT:RNA	denotes	RNA
T27176	50739-50742	CHEBI_SO_EXT:RNA	denotes	RNA
T27178	50816-50826	GO_SO_EXT:chromosome	denotes	chromosome
T27715	10565-10569	CHEBI_SO_EXT:mRNA	denotes	mRNA
T27713	10545-10555	GO:0010467	denotes	Expression
T27714	10559-10564	PR_EXT:000006549	denotes	Dmrt7
T27716	10574-10581	CHEBI_PR_EXT:protein	denotes	Protein
T27717	10586-10588	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T27718	10605-10610	PR_EXT:000006549	denotes	Dmrt7
T27719	10611-10615	CHEBI_SO_EXT:mRNA	denotes	mRNA
T27720	10625-10631	UBERON:0000062	denotes	organs
T27721	10635-10640	UBERON:0007023	denotes	adult
T27722	10641-10646	NCBITaxon:10088	denotes	mouse
T27723	10648-10652	SO_EXT:cDNA	denotes	cDNA
T27724	10663-10668	UBERON:0000062	denotes	organ
T27725	10688-10695	SO_EXT:0000112	denotes	primers
T27726	10709-10714	PR_EXT:000006549	denotes	Dmrt7
T27727	10729-10736	PR_EXT:000003676	denotes	β-actin
T27728	10755-10760	PR_EXT:000006549	denotes	Dmrt7
T27729	10761-10765	CHEBI_SO_EXT:mRNA	denotes	mRNA
T27730	10766-10776	GO:0010467	denotes	expression
T27731	10803-10818	GO:0007283	denotes	spermatogenesis
T27732	10820-10825	SO_EXT:cDNA	denotes	cDNAs
T27733	10840-10846	UBERON:0000473	denotes	testis
T27734	10875-10880	GO:0007567	denotes	birth
T27735	10911-10916	PR_EXT:000006549	denotes	DMRT7
T27736	10917-10924	CHEBI_PR_EXT:protein	denotes	protein
T27737	10925-10935	GO:0010467	denotes	expression
T27738	10959-10965	UBERON:0000473	denotes	testis
T27739	10989-10993	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T27740	11007-11015	GO:0042571	denotes	antibody
T27741	11019-11024	PR_EXT:000006549	denotes	DMRT7
T27742	11037-11041	CHEBI:51231	denotes	DAPI
T27743	11054-11059	PR_EXT:000006549	denotes	DMRT7
T27744	11060-11071	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T27745	11063-11071	CL_GO_EXT:cell	denotes	cellular
T27746	11072-11084	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T27747	11088-11095	GO:0001741	denotes	XY body
T27748	11097-11103	UBERON:0000473	denotes	Testis
T27749	11127-11131	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T27750	11145-11155	GO:0042571	denotes	antibodies
T27751	11159-11164	PR_EXT:000006549	denotes	DMRT7
T27752	11175-11181	PR_EXT:000015829	denotes	SUMO-1
T27753	11191-11197	PR_EXT:000015829	denotes	SUMO-1
T27754	11201-11210	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T27755	11218-11225	GO:0001741	denotes	XY body
T27756	11314-11323	GO:0000239	denotes	pachytene
T27757	11324-11337	CL:0000017	denotes	spermatocytes
T27758	11343-11352	GO:0001741	denotes	XY bodies
T28428	17313-17319	UBERON:0000473	denotes	Testis
T28429	17329-17338	CL:0000586	denotes	Germ Cell
T28430	17334-17338	CL_GO_EXT:cell	denotes	Cell
T28431	17334-17348	GO:0006915	denotes	Cell Apoptosis
T28432	17352-17356	NCBITaxon:10088	denotes	Mice
T28433	17371-17379	SO_EXT:sequence_deletion_entity_or_process	denotes	Deletion
T28434	17383-17388	PR_EXT:000006549	denotes	Dmrt7
T28435	17393-17399	UBERON:0000473	denotes	Testes
T28436	17416-17425	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T28437	17427-17428	SO_EXT:normal_or_wild_type_or_present	denotes	+
T28438	17429-17430	SO_EXT:normal_or_wild_type_or_present	denotes	+
T28439	17432-17437	NCBITaxon:10088	denotes	mouse
T28440	17456-17457	SO_EXT:sequence_nullness_or_absence	denotes	−
T28441	17458-17459	SO_EXT:sequence_nullness_or_absence	denotes	−
T28442	17461-17466	PR_EXT:000006549	denotes	Dmrt7
T28443	17467-17473	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T28444	17504-17510	UBERON:0000473	denotes	testes
T28445	17557-17561	NCBITaxon:10088	denotes	mice
T28446	17579-17590	CHEBI:51686	denotes	hematoxylin
T28447	17595-17600	CHEBI_EXT:eosin	denotes	eosin
T28448	17602-17611	SO_EXT:wild_type_entity_or_quality	denotes	Wild-type
T28449	17634-17640	SO_EXT:sequence_altered_entity	denotes	mutant
T28450	17719-17726	UBERON:0000025	denotes	tubules
T28451	17748-17761	CL:0000017	denotes	spermatocytes
T28452	17779-17784	CL_GO_EXT:cell	denotes	cells
T28453	17798-17807	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T28454	17858-17864	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T28455	17865-17872	UBERON:0000025	denotes	tubules
T28456	17881-17900	CL:0000228	denotes	multinucleate cells
T28457	17886-17894	GO:0005634	denotes	nucleate
T28458	17895-17900	CL_GO_EXT:cell	denotes	cells
T28459	17940-17948	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeling
T28460	17952-17957	PR_EXT:000006549	denotes	Dmrt7
T28461	17968-17973	NCBITaxon:10088	denotes	mouse
T28462	17974-17980	UBERON:0000473	denotes	testes
T28463	17982-17988	UBERON:0000473	denotes	Testes
T28464	17994-18003	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T28465	18019-18025	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T28466	18061-18069	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeling
T28467	18080-18089	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T28468	18080-18095	CL:0000445	denotes	apoptotic cells
T28469	18090-18095	CL_GO_EXT:cell	denotes	cells
T28470	18097-18103	UBERON:0000473	denotes	Testis
T28471	18144-18148	NCBITaxon:10088	denotes	mice
T28472	18154-18163	GO_PATO_EXT:apoptotic_process_or_quality	denotes	Apoptotic
T28473	18154-18169	CL:0000445	denotes	Apoptotic cells
T28474	18164-18169	CL_GO_EXT:cell	denotes	cells
T28475	18204-18224	UBERON:0001343	denotes	seminiferous tubules
T28476	18239-18244	PR_EXT:000006549	denotes	Dmrt7
T28477	18245-18251	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T28478	18252-18256	NCBITaxon:10088	denotes	mice
T28479	18269-18278	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T28955	20879-20889	GO:0007128	denotes	Prophase I
T28956	20900-20905	PR_EXT:000006549	denotes	Dmrt7
T28957	20906-20912	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T28958	20913-20923	CL:0000586	denotes	Germ Cells
T28959	20918-20923	CL_GO_EXT:cell	denotes	Cells
T28960	20924-20930	UBERON:0000473	denotes	Testis
T28961	20954-20963	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T28962	20965-20966	SO_EXT:normal_or_wild_type_or_present	denotes	+
T28963	20967-20968	SO_EXT:normal_or_wild_type_or_present	denotes	+
T28964	20974-20979	PR_EXT:000006549	denotes	Dmrt7
T28965	20980-20986	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T28966	20988-20989	SO_EXT:sequence_nullness_or_absence	denotes	−
T28967	20990-20991	SO_EXT:sequence_nullness_or_absence	denotes	−
T28968	21033-21043	GO:0042571	denotes	antibodies
T28969	21056-21069	GO:0007283	denotes	spermatogenic
T28970	21070-21075	CL_GO_EXT:cell	denotes	cells
T28971	21087-21095	GO:0042571	denotes	antibody
T28972	21112-21125	CL:0000020	denotes	spermatogonia
T28973	21148-21157	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T28974	21162-21168	SO_EXT:sequence_altered_entity	denotes	mutant
T28975	21178-21186	GO:0042571	denotes	antibody
T28976	21194-21207	CL:0000017	denotes	spermatocytes
T28977	21230-21239	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T28978	21244-21250	SO_EXT:sequence_altered_entity	denotes	mutant
T28979	21263-21271	GO:0042571	denotes	antibody
T28980	21279-21288	GO:0000239	denotes	pachytene
T28981	21299-21309	CL:0000586	denotes	germ cells
T28982	21304-21309	CL_GO_EXT:cell	denotes	cells
T28983	21347-21353	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T28984	21354-21360	UBERON:0000473	denotes	testis
T29227	21383-21390	GO:0007126	denotes	Meiotic
T29228	21401-21406	PR_EXT:000006549	denotes	Dmrt7
T29229	21407-21413	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T29230	21414-21420	UBERON:0000473	denotes	Testis
T29231	21446-21463	_FRAGMENT	denotes	meiotic stages of
T29232	21469-21474	GO:0098762	denotes	cells
T29233	21464-21474	CL:0000586	denotes	germ cells
T29234	21469-21474	CL_GO_EXT:cell	denotes	cells
T29235	21520-21526	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T29236	21543-21549	UBERON:0000473	denotes	testes
T29237	21578-21598	GO:0000795	denotes	synaptonemal complex
T29238	21599-21606	CHEBI_PR_EXT:protein	denotes	protein
T29239	21607-21612	PR_EXT:000015865	denotes	SYCP3
T29585	23000-23008	GO:0007129	denotes	Synapsis
T29586	23013-23026	GO_SO_EXT:sequence_rearrangement_process	denotes	Recombination
T29587	23030-23035	PR_EXT:000006549	denotes	Dmrt7
T29588	23036-23042	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T29589	23043-23053	CL:0000586	denotes	Germ Cells
T29590	23048-23053	CL_GO_EXT:cell	denotes	Cells
T29591	23058-23068	UBERON:0000473	denotes	Testicular
T29592	23069-23074	CL_GO_EXT:cell	denotes	cells
T29593	23080-23085	PR_EXT:000006549	denotes	Dmrt7
T29594	23100-23101	SO_EXT:normal_or_wild_type_or_present	denotes	+
T29595	23102-23103	SO_EXT:sequence_nullness_or_absence	denotes	−
T29596	23120-23121	SO_EXT:sequence_nullness_or_absence	denotes	−
T29597	23122-23123	SO_EXT:sequence_nullness_or_absence	denotes	−
T29598	23125-23131	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T29599	23132-23136	NCBITaxon:10088	denotes	mice
T29600	23166-23174	GO:0042571	denotes	antibody
T29601	23178-23183	PR_EXT:000015865	denotes	SYCP3
T29602	23219-23226	GO:0007126	denotes	meiotic
T29603	23227-23235	GO:0051324	denotes	prophase
T29604	23245-23250	PR_EXT:000015865	denotes	SYCP3
T29605	23296-23305	GO:0000239	denotes	pachynema
T29606	23311-23320	GO:0030849	denotes	autosomes
T29607	23331-23339	GO:0007129	denotes	synapsed
T29608	23364-23372	GO:0007129	denotes	synapsed
T29609	23416-23425	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T29610	23430-23436	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T29611	23437-23442	CL_GO_EXT:cell	denotes	cells
T29612	23448-23458	UBERON:0000473	denotes	Testicular
T29613	23459-23464	CL_GO_EXT:cell	denotes	cells
T29614	23468-23476	GO:0000238	denotes	zygonema
T29615	23481-23490	GO:0000239	denotes	pachynema
T29616	23515-23525	GO:0042571	denotes	antibodies
T29617	23529-23534	PR_EXT:000013672	denotes	RAD51
T29618	23547-23552	PR_EXT:000015865	denotes	SYCP3
T29619	23585-23590	PR_EXT:000013672	denotes	RAD51
T29620	23616-23625	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T29621	23630-23636	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T29622	23637-23650	CL:0000017	denotes	spermatocytes
T30257	25179-25184	PR_EXT:000007857	denotes	GATA1
T30258	25195-25199	CHEBI:51231	denotes	DAPI
T30259	25213-25225	CL:0000216	denotes	Sertoli cell
T30232	24817-24829	CL:0000216	denotes	Sertoli Cell
T30233	24825-24829	CL_GO_EXT:cell	denotes	Cell
T30234	24846-24851	PR_EXT:000006549	denotes	Dmrt7
T30235	24852-24858	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T30236	24859-24865	UBERON:0000473	denotes	Testes
T30237	24870-24876	UBERON:0000473	denotes	Testes
T30238	24886-24895	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T30239	24900-24905	PR_EXT:000006549	denotes	Dmrt7
T30240	24906-24912	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30241	24913-24917	NCBITaxon:10088	denotes	mice
T30242	24950-24958	GO:0042571	denotes	antibody
T30243	24962-24967	PR_EXT:000007859	denotes	GATA4
T30244	24977-24983	UBERON:0000473	denotes	testis
T30245	25006-25014	GO:0042571	denotes	antibody
T30246	25018-25023	PR_EXT:000007857	denotes	GATA1
T30247	25033-25038	PR_EXT:000007859	denotes	GATA4
T30248	25043-25048	PR_EXT:000007857	denotes	GATA1
T30249	25071-25080	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T30250	25085-25091	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30251	25092-25104	CL:0000216	denotes	Sertoli cell
T30252	25100-25104	CL_GO_EXT:cell	denotes	cell
T30253	25110-25119	SO_EXT:wild_type_entity_or_quality	denotes	Wild-type
T30254	25124-25130	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30255	25131-25137	UBERON:0000473	denotes	testis
T30256	25167-25175	GO:0042571	denotes	antibody
T30260	25221-25232	GO:0005634	denotes	cell nuclei
T30261	25254-25268	GO_UBERON_EXT:basement_membrane	denotes	basal membrane
T30262	25272-25281	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T30263	25287-25293	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30264	25294-25307	CL:0000216	denotes	Sertoli cells
T30265	25302-25307	CL_GO_EXT:cell	denotes	cells
T30266	25331-25338	UBERON:0000025	denotes	tubules
T30267	25392-25407	GO_UBERON_EXT:basement_membrane	denotes	basal membranes
T30268	25413-25419	UBERON:0000473	denotes	Testis
T30269	25444-25453	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T30270	25458-25470	CL:0000216	denotes	Sertoli cell
T30271	25466-25470	CL_GO_EXT:cell	denotes	cell
T30272	25480-25485	PR_EXT:000006549	denotes	Dmrt7
T30273	25486-25492	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30274	25494-25496	CL:0000216	denotes	SC
T30275	25506-25510	NCBITaxon:10088	denotes	mice
T30276	25524-25535	CHEBI:51686	denotes	hematoxylin
T30277	25540-25545	CHEBI_EXT:eosin	denotes	eosin
T30278	25547-25562	GO:0007283	denotes	Spermatogenesis
T30279	25567-25581	GO:0007286	denotes	spermiogenesis
T30280	25596-25598	CL:0000216	denotes	SC
T30281	25607-25613	UBERON:0000473	denotes	testis
T30282	25619-25625	UBERON:0000473	denotes	Testis
T30283	25650-25659	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T30284	25664-25666	CL:0000216	denotes	SC
T30285	25675-25679	NCBITaxon:10088	denotes	mice
T30286	25693-25703	GO:0042571	denotes	antibodies
T30287	25707-25712	PR_EXT:000007857	denotes	GATA1
T30288	25723-25736	UBERON:0001135	denotes	smooth muscle
T30289	25723-25742	PR_EXT:000003675	denotes	smooth muscle actin
T30290	25755-25775	UBERON:0001343	denotes	seminiferous tubules
T30291	25785-25797	CL:0000216	denotes	Sertoli cell
T30292	25793-25804	GO:0005634	denotes	cell nuclei
T30293	25838-25852	GO_UBERON_EXT:basement_membrane	denotes	basal membrane
T30294	25856-25858	CL:0000216	denotes	SC
T30295	25867-25871	NCBITaxon:10088	denotes	mice
T30775	29611-29618	GO:0001741	denotes	XY Body
T30776	29641-29650	GO:0000239	denotes	Pachynema
T30777	29654-29659	PR_EXT:000006549	denotes	Dmrt7
T30778	29660-29666	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T30779	29667-29671	NCBITaxon:10088	denotes	Mice
T30780	29676-29686	UBERON:0000473	denotes	Testicular
T30781	29687-29692	CL_GO_EXT:cell	denotes	cells
T30782	29717-29727	GO:0042571	denotes	antibodies
T30783	29747-29752	PR_EXT:000015865	denotes	SYCP3
T30784	29765-29774	GO:0000239	denotes	pachytene
T30785	29775-29780	CL_GO_EXT:cell	denotes	cells
T30786	29811-29818	GO:0001741	denotes	XY body
T30787	29827-29836	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T30788	29841-29846	PR_EXT:000006549	denotes	Dmrt7
T30789	29847-29853	SO_EXT:sequence_altered_entity	denotes	mutant
T30790	29859-29865	UBERON:0000473	denotes	Testes
T30791	29880-29884	NCBITaxon:10088	denotes	mice
T30792	29912-29920	GO:0042571	denotes	antibody
T30793	29941-29947	UBERON:0000473	denotes	Testes
T30794	29962-29966	NCBITaxon:10088	denotes	mice
T30795	29994-30002	GO:0042571	denotes	antibody
T30796	30006-30012	PR_EXT:000015829	denotes	SUMO-1
T30797	30031-30040	GO:0000239	denotes	pachytene
T30798	30041-30046	CL_GO_EXT:cell	denotes	cells
T30799	30052-30061	GO:0001741	denotes	XY bodies
T30800	30077-30086	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T30801	30091-30097	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30802	30098-30104	UBERON:0000473	denotes	testes
T31530	32061-32070	GO:0000785	denotes	Chromatin
T31531	32088-32093	PR_EXT:000006549	denotes	Dmrt7
T31532	32094-32100	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T31533	32101-32110	GO:0000240	denotes	Diplotene
T31534	32111-32121	CL:0000586	denotes	Germ Cells
T31535	32116-32121	CL_GO_EXT:cell	denotes	Cells
T31536	32160-32169	GO:0000239	denotes	pachytene
T31537	32170-32182	CL:0000017	denotes	spermatocyte
T31538	32186-32191	PR_EXT:000006549	denotes	Dmrt7
T31539	32192-32198	SO_EXT:sequence_altered_entity	denotes	mutant
T31540	32216-32223	GO:0001741	denotes	XY body
T31541	32245-32248	CHEBI_SO_EXT:RNA	denotes	RNA
T31542	32275-32287	_FRAGMENT	denotes	silencing of
T31543	32303-32316	GO:0006342	denotes	transcription
T31544	32288-32302	GO:0000803	denotes	sex chromosome
T31545	32292-32302	GO_SO_EXT:chromosome	denotes	chromosome
T31546	32320-32327	GO:0001741	denotes	XY body
T31547	32353-32362	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T31548	32367-32376	GO:0000239	denotes	pachynema
T31549	32417-32421	PR_EXT:000005082	denotes	HP1β
T31550	32422-32434	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T31551	32442-32451	GO:0000239	denotes	pachytene
T31552	32452-32465	CL:0000017	denotes	spermatocytes
T31553	32467-32471	PR_EXT:000005082	denotes	HP1β
T31554	32472-32481	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T31555	32485-32497	GO:0000805	denotes	X chromosome
T31556	32487-32497	GO_SO_EXT:chromosome	denotes	chromosome
T31557	32498-32508	GO_SO_EXT:centromere_or_centromeric_region_or_centromeric_orientation	denotes	centromere
T31558	32524-32533	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T31559	32542-32548	SO_EXT:sequence_altered_entity	denotes	mutant
T31560	32570-32583	GO:0097617	denotes	hybridization
T31561	32587-32596	GO:0000240	denotes	diplotene
T31562	32610-32617	GO:0001741	denotes	XY body
T31563	32628-32632	CHEBI:51231	denotes	DAPI
T31564	32643-32655	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T31565	32697-32701	PR_EXT:000005082	denotes	HP1β
T31566	32705-32714	GO:0000240	denotes	diplotene
T31567	32716-32725	SO_EXT:wild_type_entity_or_quality	denotes	Wild-type
T31568	32726-32730	CL_GO_EXT:cell	denotes	cell
T31569	32739-32743	PR_EXT:000005082	denotes	HP1β
T31570	32755-32762	GO:0001741	denotes	XY body
T31571	32772-32778	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T31572	32779-32783	CL_GO_EXT:cell	denotes	cell
T31573	32797-32809	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T31574	32813-32825	GO:0000805	denotes	X chromosome
T31575	32815-32825	GO_SO_EXT:chromosome	denotes	chromosome
T31576	32826-32836	GO_SO_EXT:centromere_or_centromeric_region_or_centromeric_orientation	denotes	centromere
T31577	32860-32862	PR_EXT:000027594	denotes	H3
T31578	32860-32868	SO_EXT:0001728	denotes	H3-2meK9
T31579	32869-32881	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T31580	32885-32894	GO:0000240	denotes	diplotene
T31581	32895-32900	CL_GO_EXT:cell	denotes	cells
T31582	32902-32908	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T31583	32909-32913	CL_GO_EXT:cell	denotes	cell
T31584	32953-32957	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	mark
T31585	32965-32972	GO:0001741	denotes	XY body
T31586	32981-32990	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T31587	33006-33008	PR_EXT:000027594	denotes	H3
T31588	33006-33014	SO_EXT:0001707	denotes	H3-3meK9
T31589	33015-33027	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T31590	33031-33040	GO:0000240	denotes	diplotene
T31591	33041-33046	CL_GO_EXT:cell	denotes	cells
T31592	33048-33054	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T31593	33055-33059	CL_GO_EXT:cell	denotes	cell
T31594	33071-33083	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T31595	33092-33096	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	mark
T31596	33104-33111	GO:0001741	denotes	XY body
T31597	33119-33128	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localizes
T31598	33132-33141	GO:0030849	denotes	autosomes
T31599	33145-33151	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T31600	33152-33156	CL_GO_EXT:cell	denotes	cell
T31601	33187-33196	GO:0006915	denotes	apoptosis
T31602	33213-33219	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T31603	33220-33229	GO:0000240	denotes	diplotene
T31604	33230-33234	CL_GO_EXT:cell	denotes	cell
T31605	33247-33251	PR_EXT:000005082	denotes	HP1β
T31606	33272-33279	GO:0001741	denotes	XY body
T32076	36060-36073	GO:0001739	denotes	Sex Chromatin
T32077	36077-36082	CL_GO_EXT:cell	denotes	Cells
T32078	36093-36103	GO_SO_EXT:chromosome	denotes	Chromosome
T32079	36093-36111	GO:0007129	denotes	Chromosome Pairing
T32080	36133-36142	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T32081	36143-36152	CL:0000586	denotes	germ cell
T32082	36148-36152	CL_GO_EXT:cell	denotes	cell
T32083	36166-36170	CHEBI:51231	denotes	DAPI
T32084	36177-36182	PR_EXT:000015865	denotes	SYCP3
T32085	36193-36197	PR_EXT:000005082	denotes	HP1β
T32086	36206-36216	GO_SO_EXT:chromosome	denotes	chromosome
T32087	36239-36248	GO:0000240	denotes	diplonema
T32088	36266-36273	GO:0001741	denotes	XY body
T32089	36279-36283	PR_EXT:000005082	denotes	HP1β
T32090	36312-36317	PR_EXT:000006549	denotes	Dmrt7
T32091	36318-36324	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T32092	36325-36334	CL:0000586	denotes	germ cell
T32093	36330-36334	CL_GO_EXT:cell	denotes	cell
T32094	36350-36359	GO:0000240	denotes	diplotene
T32095	36360-36370	GO_SO_EXT:chromosome	denotes	chromosome
T32096	36399-36406	GO:0001741	denotes	XY body
T32097	36415-36419	PR_EXT:000005082	denotes	HP1β
T32098	36440-36447	GO:0001741	denotes	XY body
T32099	36452-36462	GO_SO_EXT:chromosome	denotes	chromosome
R8200	T29232	T29231	_lexicallyChainedTo	cells,meiotic stages of
R8702	T31543	T31542	_lexicallyChainedTo	transcription,silencing of
R4	T782	T781	_lexicallyChainedTo	trimethylation,histone H3K9
R309	T3784	T3783	_lexicallyChainedTo	chromosome,X
R310	T3789	T3788	_lexicallyChainedTo	chromosome,portions of
R311	T3792	T3791	_lexicallyChainedTo	mammals,eutherian
R312	T3962	T3961	_lexicallyChainedTo	germ cells,male
R2065	T8076	T8075	_lexicallyChainedTo	cells,embryonic stem
R2066	T8076	T8077	_lexicallyChainedTo	cells,ES
R2380	T9592	T9591	_lexicallyChainedTo	Gametogenesis,Male
R2381	T9641	T9640	_lexicallyChainedTo	cells,stages of
R2382	T9669	T9668	_lexicallyChainedTo	nuclei,cells with
R3374	T13010	T13009	_lexicallyChainedTo	cells,nuclei of
R3796	T14587	T14586	_lexicallyChainedTo	chromosomes,Condensation of
R3797	T14589	T14588	_lexicallyChainedTo	chromosomes,X
R3798	T14634	T14633	_lexicallyChainedTo	chromosomes,X
R5081	T21424	T21423	_lexicallyChainedTo	chromosomes,X
R5082	T21482	T21481	_lexicallyChainedTo	chromatin,modification of
R1	T737	T736	_lexicallyChainedTo	heterochromatin domain,formation of
R2	T780	T779	_lexicallyChainedTo	methylation,histone H3K9 di-

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