PMC:1852721 / 67014-67779 JSONTXT

{"project":"2_test","denotations":[{"id":"17357067-12637750-2054090","span":{"begin":483,"end":485},"obj":"12637750"}],"text":"Loss of imprinting (LOI), an epigenetic alteration, has also been found in cancers. LOI of the gene encoding insulinlike growth factor II (IGF2 [MIM +147470]) has been described for Wilms tumor (MIM #194070), in Beckwith-Wiedemann syndrome (MIM #130650), and in hepatoblastoma. LOI of IGF2 is found in normal colonic mucosa of ∼30% of patients with colorectal cancer (MIM #114500) but in only ∼10% of normal individuals. In a study of 172 patients in a colonoscopy clinic, Cui et al.74 found that the adjusted odds ratio for LOI of IGF2 in lymphocytes was 5.15 for patients with a positive family history, 3.46 for patients with adenomas, and 21.7 for patients with colorectal cancer. Other work supported the idea that LOI of IGF2 may be a familial characteristic."}