PMC:1852721 / 65989-66734 JSONTXT

{"project":"2_test","denotations":[{"id":"17357067-12082624-2054088","span":{"begin":503,"end":505},"obj":"12082624"}],"text":"Thus, in addition to the \u003e2,000 genes for which one or more specific disease-related mutations have been found, other genes cataloged in OMIM are important to the pathogenesis of cancers through epigenetic mechanisms. These are tumor-suppressor genes silenced through hypermethylation. Examples include the RASSF1 gene (MIM *605082) on 3p21, which is often deleted or its promoter hypermethylated in lung cancer. This gene shows anomalous promoter hypermethylation in a large number of other tumor types72 as well. As indicated by their names, other tumor-suppressor genes related to cancers through epigenetic silencing are “hypermethylated in cancer-1” (HIC1 [MIM *603825]) on 17p and “hypermethylated in cancer-2” (HIC2 [MIM *607712]) on 22q."}