PMC:1852721 / 58924-59534 JSONTXT

{"project":"2_test","denotations":[{"id":"17357067-11479736-2054083","span":{"begin":174,"end":176},"obj":"11479736"}],"text":"As more is learned about Mendelian disorders, complexities come to light that indicate that most of these also must be viewed as multifactorial or at least as complex traits.38 Modifier genes/loci implicated in Mendelian disorders are being identified—for example, the cystic fibrosis modifier-1 locus (CFM1 [MIM 603855]) in cystic fibrosis. Imprinting is an important factor contributing to the complexity of inheritance in a number of genetic disorders. In the instance of the many Mendelian disorders that are caused by expanded repeats, the random loss and gain in number of repeats introduce complexities."}