PMC:1852721 / 42087-43018 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1852721","sourcedb":"PMC","sourceid":"1852721","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1852721","text":"Classically, the determinants of variation are divided into genetic and environmental (a.k.a. exogenous or nongenetic). Random variation, “chance,” is also an important determinant. A useful demonstration of both genetics and chance (stochastic variation) in determination of a particular phenotype is provided by dermatoglyphic patterns (MIM %125590): presumably, “fingerprints” are different in every human being, even identical twins. The basic differences are laid down by the DNA of the individual; additional differentiation is provided by stochastic differences in the embryologic development of the finger pads, even in individuals with a shared genome, identical twins. (For a discussion of the difference between DNA fingerprint and dermatoglyphic fingerprints and an illustrative comparison of the two types in a pair of MZ twins, see the report of the National Research Council on DNA technology in forensic science.39)","tracks":[]}