PMC:1852721 / 39925-40733 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1852721","sourcedb":"PMC","sourceid":"1852721","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1852721","text":"Most forms of cancer are clearly multifactorial, indeed multigenic. All are fundamentally genetic, based on changes in the genetic material; for the most part, they are somatic genetic disorders. Epigenetic changes are also importantly involved, as discussed below. In many sporadic forms of cancer, multiple genes have been identified as playing a role in initiation, progression, invasion, metastasis, and resistance to therapy. OMIM records these somatic mutations among AVs. Somatic mutations related to prostate cancer (MIM #176807) are recorded for at least eight genes and, in the case of some of these genes, both familial and sporadic forms of prostate cancer are represented. Colorectal cancer (MIM #114500) displays an even more extensive array of genes involved in familial and/or sporadic forms.","tracks":[]}