PMC:1852721 / 38969-39924 JSONTXT

{"project":"2_test","denotations":[{"id":"17357067-11479736-2054054","span":{"begin":874,"end":876},"obj":"11479736"}],"text":"Largely on the basis of Garrodian thinking, Childs, in 1999,37 developed what he called “a logic of medicine,” defining logic as a statement of the formal principles underlying a branch of knowledge. From these analyses came a vision of individualized medicine—a brand of medicine designed to match the uniqueness of the individual and encompassing all disease, including common disease. Despite its title Mendelian Inheritance in Man, there are reasons why identifiable genetic factors in all disease including those that are not strictly Mendelian should be included in OMIM (see below). These are the common disorders previously labeled “multifactorial” and now usually termed “complex traits” (or disorders). The more we know about classic Mendelian disorders, the more we realize that these are also complex; see the example of glycerol kinase deficiency (MIM #307030).38 Conversely, Mendelian subtypes of common complex disorders have come to light."}