PMC:1852316 / 27832-28711 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1852316","sourcedb":"PMC","sourceid":"1852316","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1852316","text":"Kinetic cell models hold great promise for predicting cell behavior [28-32]. Unfortunately there is a lack of information about many of the rate and equilibrium constants for the reaction and transport processes involved [33,34]. Simultaneously calibrating all the reaction/transport rate parameters and discovering the gene/TF interaction network structure from available data does not appear to be feasible. Therefore, instead of using a kinetic approach as a basis of TRN construction, we have developed FTF (Fast Transcription Factor analyzer) for network construction via (1) TF activity estimation, (2) statistical arguments, and (3) a preliminary TRN. Once a reliable TRN is obtained using FTF, it can then be used to calibrate the rate and equilibrium constants that appear in transcription/translation kinetic models. An example of such an approach is available at [35].","tracks":[{"project":"2_test","denotations":[{"id":"17397539-14573350-1689499","span":{"begin":69,"end":71},"obj":"14573350"},{"id":"17397539-14642755-1689499","span":{"begin":69,"end":71},"obj":"14642755"},{"id":"17397539-15178194-1689499","span":{"begin":69,"end":71},"obj":"15178194"},{"id":"17397539-14583116-1689499","span":{"begin":69,"end":71},"obj":"14583116"},{"id":"17397539-9927716-1689500","span":{"begin":222,"end":224},"obj":"9927716"}],"attributes":[{"subj":"17397539-14573350-1689499","pred":"source","obj":"2_test"},{"subj":"17397539-14642755-1689499","pred":"source","obj":"2_test"},{"subj":"17397539-15178194-1689499","pred":"source","obj":"2_test"},{"subj":"17397539-14583116-1689499","pred":"source","obj":"2_test"},{"subj":"17397539-9927716-1689500","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecbe93","default":true}]}]}}