PMC:1794230 / 6721-7395 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1794230","sourcedb":"PMC","sourceid":"1794230","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1794230","text":"MONKEY requires that all sequences be multiply aligned. However, this requirement is too restrictive for many transcription factors of interest that are conserved across a broad phylogenetic range. That is, there are many cases in which distantly related species contain orthologous transcription factors and binding sites, even though general sequence alignments are not feasible (e.g., between eubacteria and archaea [13-15]). Thus, we have developed a scanning approach that will find sites in mixed data that can include one or more clades of sequences (each of which can be aligned reliably) as well as sequences which cannot be aligned reliably to any other sequences.","tracks":[{"project":"2_test","denotations":[{"id":"17244358-10635322-1689306","span":{"begin":420,"end":422},"obj":"10635322"},{"id":"17244358-12368242-1689306","span":{"begin":420,"end":422},"obj":"12368242"},{"id":"17244358-14641908-1689306","span":{"begin":420,"end":422},"obj":"14641908"}],"attributes":[{"subj":"17244358-10635322-1689306","pred":"source","obj":"2_test"},{"subj":"17244358-12368242-1689306","pred":"source","obj":"2_test"},{"subj":"17244358-14641908-1689306","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#eca093","default":true}]}]}}