PMC:1794230 / 57425-58173 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1794230","sourcedb":"PMC","sourceid":"1794230","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1794230","text":"To test the sensitivity and specificity of PhyloScan when seeking binding sites that are weaker than E. coli Crp binding sites, we generated \"1/2-strength\" and \"1/3-strength\" Crp sites. The 1/2-strength Crp motif was designed to have an average information content per column that is half the average information content of the full-strength Crp motif; we did this by raising each probability of a nucleotide to its 0.637th power, with subsequent scaling so that the probabilities of the four nucleotides for any motif column sum to 1.0. Likewise, the 1/3-strength Crp sites were generated from a 1/3-strength Crp motif to give one-third the average information content, using an exponent of 0.507. See Figure 1 and its legend for more information.","tracks":[]}