PMC:1794230 / 36901-37815 JSONTXT

{"project":"2_test","denotations":[{"id":"17244358-12883005-1689320","span":{"begin":733,"end":735},"obj":"12883005"}],"text":"On the other hand, in calculating the q-value, we have assumed that the vast majority of intergenic sequences in a genome will likely not contain a transcription factor binding site for the particular transcription factor under study, i.e., we are looking for rare events. Under this assumption, the proportion of all intergenic sequences that are truly null will approach 1.0 in Storey and Tibshirani's q-value calculation (the π^0 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacuWFapaCgaqcamaaBaaaleaacqaIWaamaeqaaaaa@2F9A@ term of [16]), and so does not appear in our q-value equation (see Methods). In a case where this assumption does not hold, the q-values provided by our approach will be overly conservative."}