PMC:1794230 / 2094-3001 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1794230","sourcedb":"PMC","sourceid":"1794230","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1794230","text":"Alteration of the frequency of transcription from DNA to messenger RNA is the primary means by which an organism controls gene expression. Transcription initiation is controlled primarily through the binding of transcription factors (proteins) to cognate sites on a chromosome (transcription factor binding sites). For a given transcription factor and an experimentally identified set of transcription factor binding sites, or a set of co-regulated promoters, computational methods can be applied to identify the DNA sequence pattern that is recognized by the transcription factor. Such a sequence pattern is commonly referred to as a motif, which is a conceptual extension of a single sequence, in which each position is characterized not by a single nucleotide, but rather by a column vector representing the probability with which each of the four nucleotides contributes to the pattern at that position.","tracks":[]}