PMC:17827 / 1068-1701
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/17827","sourcedb":"PMC","sourceid":"17827","source_url":"http://www.ncbi.nlm.nih.gov/pmc/17827","text":"Introduction:\nActivated SFB in the invasive pannus tissue appear to play a major role in the crippling destruction of cartilage and bone in the joints of patients with RA [1,2,3]. Several studies indicate that RA-SFB are morphologically altered [1,4], grow in an anchorage-independent fashion [5], and strongly express markers of activation, including major histocompatibility complex (MHC)-II and other surface molecules, proto-oncogenes, or matrix degrading enzymes (reviewed in [2]). Finally, activated RA-SFB elicit erosive arthritis upon intra-articular injection or engraftment into severe combined immunodeficiency mice [6,7].","divisions":[{"label":"Title","span":{"begin":0,"end":13}}],"tracks":[{"project":"2_test","denotations":[{"id":"11178129-8912499-4386791","span":{"begin":172,"end":173},"obj":"8912499"},{"id":"11178129-7632096-4386792","span":{"begin":174,"end":175},"obj":"7632096"},{"id":"11178129-2109776-4386793","span":{"begin":176,"end":177},"obj":"2109776"},{"id":"11178129-8912499-4386794","span":{"begin":246,"end":247},"obj":"8912499"},{"id":"11178129-6851475-4386795","span":{"begin":248,"end":249},"obj":"6851475"},{"id":"11178129-2784799-4386796","span":{"begin":294,"end":295},"obj":"2784799"},{"id":"11178129-7632096-4386797","span":{"begin":482,"end":483},"obj":"7632096"},{"id":"11178129-8151561-4386798","span":{"begin":628,"end":629},"obj":"8151561"},{"id":"11178129-8909250-4386799","span":{"begin":630,"end":631},"obj":"8909250"}],"attributes":[{"subj":"11178129-8912499-4386791","pred":"source","obj":"2_test"},{"subj":"11178129-7632096-4386792","pred":"source","obj":"2_test"},{"subj":"11178129-2109776-4386793","pred":"source","obj":"2_test"},{"subj":"11178129-8912499-4386794","pred":"source","obj":"2_test"},{"subj":"11178129-6851475-4386795","pred":"source","obj":"2_test"},{"subj":"11178129-2784799-4386796","pred":"source","obj":"2_test"},{"subj":"11178129-7632096-4386797","pred":"source","obj":"2_test"},{"subj":"11178129-8151561-4386798","pred":"source","obj":"2_test"},{"subj":"11178129-8909250-4386799","pred":"source","obj":"2_test"}]},{"project":"Colil","denotations":[{"id":"T1","span":{"begin":628,"end":629},"obj":"8151561"},{"id":"T2","span":{"begin":630,"end":631},"obj":"8909250"},{"id":"T3","span":{"begin":482,"end":483},"obj":"7632096"},{"id":"T4","span":{"begin":172,"end":173},"obj":"8912499"},{"id":"T5","span":{"begin":174,"end":175},"obj":"7632096"},{"id":"T6","span":{"begin":176,"end":177},"obj":"2109776"},{"id":"T7","span":{"begin":628,"end":629},"obj":"8151561"},{"id":"T8","span":{"begin":630,"end":631},"obj":"8909250"},{"id":"T9","span":{"begin":246,"end":247},"obj":"8912499"},{"id":"T10","span":{"begin":248,"end":249},"obj":"6851475"},{"id":"T11","span":{"begin":294,"end":295},"obj":"2784799"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/"}],"attributes":[{"subj":"T1","pred":"source","obj":"Colil"},{"subj":"T2","pred":"source","obj":"Colil"},{"subj":"T3","pred":"source","obj":"Colil"},{"subj":"T4","pred":"source","obj":"Colil"},{"subj":"T5","pred":"source","obj":"Colil"},{"subj":"T6","pred":"source","obj":"Colil"},{"subj":"T7","pred":"source","obj":"Colil"},{"subj":"T8","pred":"source","obj":"Colil"},{"subj":"T9","pred":"source","obj":"Colil"},{"subj":"T10","pred":"source","obj":"Colil"},{"subj":"T11","pred":"source","obj":"Colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93eca1","default":true},{"id":"Colil","color":"#ec939f"}]}]}}