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PMC:1713256 / 33522-37365 JSONTXT

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Id Subject Object Predicate Lexical cue
T8409 0-4 NN denotes Bone
T8410 5-14 NN denotes formation
T8411 21-27 VBZ denotes occurs
T8412 15-20 RB denotes first
T8413 28-30 IN denotes at
T8414 31-34 DT denotes the
T8415 35-44 NN denotes interface
T8416 45-52 IN denotes between
T8417 53-56 DT denotes the
T8418 75-87 NNS denotes chondrocytes
T8419 57-61 JJ denotes late
T8420 62-74 JJ denotes hypertrophic
T8421 88-91 CC denotes and
T8422 92-95 DT denotes the
T8423 108-121 NN denotes perichondrium
T8424 96-107 VBG denotes surrounding
T8425 121-123 , denotes ,
T8426 123-124 DT denotes a
T8427 125-131 NN denotes region
T8428 132-142 VBN denotes identified
T8429 143-145 IN denotes as
T8430 146-149 DT denotes the
T8431 155-161 NN denotes collar
T8432 150-154 NN denotes bone
T8433 161-162 . denotes .
T8434 162-336 sentence denotes We examined whether the osteogenesis program is initiated in the BMP2, BMP4–deficient limbs using several histological and molecular criteria, as described below (Figure 5).
T8435 163-165 PRP denotes We
T8436 166-174 VBD denotes examined
T8437 175-182 IN denotes whether
T8438 211-220 VBN denotes initiated
T8439 183-186 DT denotes the
T8440 200-207 NN denotes program
T8441 187-199 NN denotes osteogenesis
T8442 208-210 VBZ denotes is
T8443 221-223 IN denotes in
T8444 224-227 DT denotes the
T8445 249-254 NNS denotes limbs
T8446 228-232 NN denotes BMP2
T8447 234-238 NN denotes BMP4
T8448 232-234 , denotes ,
T8449 239-248 JJ denotes deficient
T8450 238-239 HYPH denotes –
T8451 255-260 VBG denotes using
T8452 261-268 JJ denotes several
T8453 296-304 NNS denotes criteria
T8454 269-281 JJ denotes histological
T8455 282-285 CC denotes and
T8456 286-295 JJ denotes molecular
T8457 304-306 , denotes ,
T8458 306-308 IN denotes as
T8459 309-318 VBN denotes described
T8460 319-324 RB denotes below
T8461 325-326 -LRB- denotes (
T8462 326-332 NN denotes Figure
T8463 333-334 CD denotes 5
T8464 334-335 -RRB- denotes )
T8465 335-336 . denotes .
T8466 336-470 sentence denotes Adjacent to the hypertrophic cells, a bone collar is laid down normally in the absence of BMP2 and BMP4 (Figure 5A and 5B, red star).
T8467 337-345 JJ denotes Adjacent
T8468 390-394 VBN denotes laid
T8469 346-348 IN denotes to
T8470 349-352 DT denotes the
T8471 366-371 NNS denotes cells
T8472 353-365 JJ denotes hypertrophic
T8473 371-373 , denotes ,
T8474 373-374 DT denotes a
T8475 380-386 NN denotes collar
T8476 375-379 NN denotes bone
T8477 387-389 VBZ denotes is
T8478 395-399 RP denotes down
T8479 400-408 RB denotes normally
T8480 409-411 IN denotes in
T8481 412-415 DT denotes the
T8482 416-423 NN denotes absence
T8483 424-426 IN denotes of
T8484 427-431 NN denotes BMP2
T8485 432-435 CC denotes and
T8486 436-440 NN denotes BMP4
T8487 441-442 -LRB- denotes (
T8488 464-468 NN denotes star
T8489 442-448 NN denotes Figure
T8490 449-451 NN denotes 5A
T8491 452-455 CC denotes and
T8492 456-458 NN denotes 5B
T8493 458-460 , denotes ,
T8494 460-463 JJ denotes red
T8495 468-469 -RRB- denotes )
T8496 469-470 . denotes .
T8497 470-643 sentence denotes As can be seen in sagittal sections through an E15.5 humerus, the cells embedded in the mineralized matrix express the osteoblast marker Col I as normal (Figure 5C and 5D).
T8498 471-473 IN denotes As
T8499 481-485 VBN denotes seen
T8500 474-477 MD denotes can
T8501 478-480 VB denotes be
T8502 578-585 VBP denotes express
T8503 486-488 IN denotes in
T8504 489-497 JJ denotes sagittal
T8505 498-506 NNS denotes sections
T8506 507-514 IN denotes through
T8507 515-517 DT denotes an
T8508 524-531 NN denotes humerus
T8509 518-523 NN denotes E15.5
T8510 531-533 , denotes ,
T8511 533-536 DT denotes the
T8512 537-542 NNS denotes cells
T8513 543-551 VBN denotes embedded
T8514 552-554 IN denotes in
T8515 555-558 DT denotes the
T8516 571-577 NN denotes matrix
T8517 559-570 VBN denotes mineralized
T8518 586-589 DT denotes the
T8519 601-607 NN denotes marker
T8520 590-600 NN denotes osteoblast
T8521 608-611 NN denotes Col
T8522 612-613 CD denotes I
T8523 614-616 IN denotes as
T8524 617-623 JJ denotes normal
T8525 624-625 -LRB- denotes (
T8526 632-634 NN denotes 5C
T8527 625-631 NN denotes Figure
T8528 635-638 CC denotes and
T8529 639-641 NN denotes 5D
T8530 641-642 -RRB- denotes )
T8531 642-643 . denotes .
T8532 643-931 sentence denotes By E17.5, the mineralized cartilage that makes up the late hypertrophic zone of the growth plate normally undergoes removal by osteoclasts (Figure 5G, brown-stained cells, red arrows), resulting in the formation of a bone marrow cavity (red arrow in Figure 5E and 5I, see also Figure 6).
T8533 644-646 IN denotes By
T8534 750-759 VBZ denotes undergoes
T8535 647-652 NN denotes E17.5
T8536 652-654 , denotes ,
T8537 654-657 DT denotes the
T8538 670-679 NN denotes cartilage
T8539 658-669 JJ denotes mineralized
T8540 680-684 WDT denotes that
T8541 685-690 VBZ denotes makes
T8542 691-693 RP denotes up
T8543 694-697 DT denotes the
T8544 716-720 NN denotes zone
T8545 698-702 JJ denotes late
T8546 703-715 JJ denotes hypertrophic
T8547 721-723 IN denotes of
T8548 724-727 DT denotes the
T8549 735-740 NN denotes plate
T8550 728-734 NN denotes growth
T8551 741-749 RB denotes normally
T8552 760-767 NN denotes removal
T8553 768-770 IN denotes by
T8554 771-782 NNS denotes osteoclasts
T8555 783-784 -LRB- denotes (
T8556 820-826 NNS denotes arrows
T8557 784-790 NN denotes Figure
T8558 791-793 NN denotes 5G
T8559 793-795 , denotes ,
T8560 795-800 JJ denotes brown
T8561 801-808 VBN denotes stained
T8562 800-801 HYPH denotes -
T8563 809-814 NNS denotes cells
T8564 814-816 , denotes ,
T8565 816-819 JJ denotes red
T8566 826-827 -RRB- denotes )
T8567 827-829 , denotes ,
T8568 829-838 VBG denotes resulting
T8569 839-841 IN denotes in
T8570 842-845 DT denotes the
T8571 846-855 NN denotes formation
T8572 856-858 IN denotes of
T8573 859-860 DT denotes a
T8574 873-879 NN denotes cavity
T8575 861-865 NN denotes bone
T8576 866-872 NN denotes marrow
T8577 880-881 -LRB- denotes (
T8578 885-890 NN denotes arrow
T8579 881-884 JJ denotes red
T8580 891-893 IN denotes in
T8581 894-900 NN denotes Figure
T8582 901-903 NN denotes 5E
T8583 904-907 CC denotes and
T8584 908-910 NN denotes 5I
T8585 910-912 , denotes ,
T8586 912-915 VB denotes see
T8587 916-920 RB denotes also
T8588 921-927 NN denotes Figure
T8589 928-929 CD denotes 6
T8590 929-930 -RRB- denotes )
T8591 930-931 . denotes .
T8592 931-1148 sentence denotes Osteoprogenitor cells from bone collar region now populate this site and deposit osteoid, forming the trabecular bone in the bone marrow cavity (Figure 6E, red arrow) and cortical bone at birth (Figure 5I, asterisk).
T8593 932-947 NN denotes Osteoprogenitor
T8594 948-953 NNS denotes cells
T8595 982-990 VBP denotes populate
T8596 954-958 IN denotes from
T8597 959-963 NN denotes bone
T8598 971-977 NN denotes region
T8599 964-970 NN denotes collar
T8600 978-981 RB denotes now
T8601 991-995 DT denotes this
T8602 996-1000 NN denotes site
T8603 1001-1004 CC denotes and
T8604 1005-1012 VBP denotes deposit
T8605 1013-1020 NN denotes osteoid
T8606 1020-1022 , denotes ,
T8607 1022-1029 VBG denotes forming
T8608 1030-1033 DT denotes the
T8609 1045-1049 NN denotes bone
T8610 1034-1044 JJ denotes trabecular
T8611 1050-1052 IN denotes in
T8612 1053-1056 DT denotes the
T8613 1069-1075 NN denotes cavity
T8614 1057-1061 NN denotes bone
T8615 1062-1068 NN denotes marrow
T8616 1076-1077 -LRB- denotes (
T8617 1092-1097 NN denotes arrow
T8618 1077-1083 NN denotes Figure
T8619 1084-1086 NN denotes 6E
T8620 1086-1088 , denotes ,
T8621 1088-1091 JJ denotes red
T8622 1097-1098 -RRB- denotes )
T8623 1099-1102 CC denotes and
T8624 1103-1111 JJ denotes cortical
T8625 1112-1116 NN denotes bone
T8626 1117-1119 IN denotes at
T8627 1120-1125 NN denotes birth
T8628 1126-1127 -LRB- denotes (
T8629 1138-1146 NN denotes asterisk
T8630 1127-1133 NN denotes Figure
T8631 1134-1136 NN denotes 5I
T8632 1136-1138 , denotes ,
T8633 1146-1147 -RRB- denotes )
T8634 1147-1148 . denotes .
T8635 1148-1278 sentence denotes In contrast, in E17.5 limbs deficient in BMP2 and BMP4, there is an overall delay in the normal endochondral process (Figure 5F).
T8636 1149-1151 IN denotes In
T8637 1211-1213 VBZ denotes is
T8638 1152-1160 NN denotes contrast
T8639 1160-1162 , denotes ,
T8640 1162-1164 IN denotes in
T8641 1165-1170 NN denotes E17.5
T8642 1171-1176 NNS denotes limbs
T8643 1177-1186 JJ denotes deficient
T8644 1187-1189 IN denotes in
T8645 1190-1194 NN denotes BMP2
T8646 1195-1198 CC denotes and
T8647 1199-1203 NN denotes BMP4
T8648 1203-1205 , denotes ,
T8649 1205-1210 EX denotes there
T8650 1214-1216 DT denotes an
T8651 1225-1230 NN denotes delay
T8652 1217-1224 JJ denotes overall
T8653 1231-1233 IN denotes in
T8654 1234-1237 DT denotes the
T8655 1258-1265 NN denotes process
T8656 1238-1244 JJ denotes normal
T8657 1245-1257 JJ denotes endochondral
T8658 1266-1267 -LRB- denotes (
T8659 1274-1276 NN denotes 5F
T8660 1267-1273 NN denotes Figure
T8661 1276-1277 -RRB- denotes )
T8662 1277-1278 . denotes .
T8663 1278-1541 sentence denotes While vascularization occurs in Bmp2C/C; Bmp4C/C; Prx1::cre forelimbs, few osteoclasts are recruited to the mineralized cartilage (compare Figure 5G and Figure 5H, red arrows), resulting in a delay in bone marrow cavity formation in the absence of BMP2 and BMP4.
T8664 1279-1284 IN denotes While
T8665 1301-1307 VBZ denotes occurs
T8666 1285-1300 NN denotes vascularization
T8667 1370-1379 VBN denotes recruited
T8668 1308-1310 IN denotes in
T8669 1311-1316 NN denotes Bmp2C
T8670 1317-1318 NN denotes C
T8671 1316-1317 HYPH denotes /
T8672 1339-1348 NNS denotes forelimbs
T8673 1318-1319 : denotes ;
T8674 1320-1325 NN denotes Bmp4C
T8675 1326-1327 NN denotes C
T8676 1325-1326 HYPH denotes /
T8677 1327-1328 : denotes ;
T8678 1329-1333 NN denotes Prx1
T8679 1335-1338 NN denotes cre
T8680 1333-1334 HYPH denotes :
T8681 1334-1335 HYPH denotes :
T8682 1348-1350 , denotes ,
T8683 1350-1353 JJ denotes few
T8684 1354-1365 NNS denotes osteoclasts
T8685 1366-1369 VBP denotes are
T8686 1380-1382 IN denotes to
T8687 1383-1386 DT denotes the
T8688 1399-1408 NN denotes cartilage
T8689 1387-1398 VBN denotes mineralized
T8690 1409-1410 -LRB- denotes (
T8691 1447-1453 NNS denotes arrows
T8692 1410-1417 VB denotes compare
T8693 1418-1424 NN denotes Figure
T8694 1425-1427 NN denotes 5G
T8695 1428-1431 CC denotes and
T8696 1432-1438 NN denotes Figure
T8697 1439-1441 NN denotes 5H
T8698 1441-1443 , denotes ,
T8699 1443-1446 JJ denotes red
T8700 1453-1454 -RRB- denotes )
T8701 1454-1456 , denotes ,
T8702 1456-1465 VBG denotes resulting
T8703 1466-1468 IN denotes in
T8704 1469-1470 DT denotes a
T8705 1471-1476 NN denotes delay
T8706 1477-1479 IN denotes in
T8707 1480-1484 NN denotes bone
T8708 1485-1491 NN denotes marrow
T8709 1499-1508 NN denotes formation
T8710 1492-1498 NN denotes cavity
T8711 1509-1511 IN denotes in
T8712 1512-1515 DT denotes the
T8713 1516-1523 NN denotes absence
T8714 1524-1526 IN denotes of
T8715 1527-1531 NN denotes BMP2
T8716 1532-1535 CC denotes and
T8717 1536-1540 NN denotes BMP4
T8718 1540-1541 . denotes .
T8719 1541-1799 sentence denotes In fact, bone marrow formation and trabecular bone formation have not yet started at birth in the absence of BMP2 and BMP4 (Figure 5J), and the morphology of Bmp2C/C; Bmp4C/C; Prx1::cre bones at birth is most similar to control embryos at E17.5 (Figure 5E).
T8720 1542-1544 IN denotes In
T8721 1616-1623 VBN denotes started
T8722 1545-1549 NN denotes fact
T8723 1549-1551 , denotes ,
T8724 1551-1555 NN denotes bone
T8725 1556-1562 NN denotes marrow
T8726 1563-1572 NN denotes formation
T8727 1573-1576 CC denotes and
T8728 1577-1587 JJ denotes trabecular
T8729 1593-1602 NN denotes formation
T8730 1588-1592 NN denotes bone
T8731 1603-1607 VBP denotes have
T8732 1608-1611 RB denotes not
T8733 1612-1615 RB denotes yet
T8734 1624-1626 IN denotes at
T8735 1627-1632 NN denotes birth
T8736 1633-1635 IN denotes in
T8737 1636-1639 DT denotes the
T8738 1640-1647 NN denotes absence
T8739 1648-1650 IN denotes of
T8740 1651-1655 NN denotes BMP2
T8741 1656-1659 CC denotes and
T8742 1660-1664 NN denotes BMP4
T8743 1665-1666 -LRB- denotes (
T8744 1673-1675 NN denotes 5J
T8745 1666-1672 NN denotes Figure
T8746 1675-1676 -RRB- denotes )
T8747 1676-1678 , denotes ,
T8748 1678-1681 CC denotes and
T8749 1682-1685 DT denotes the
T8750 1686-1696 NN denotes morphology
T8751 1743-1745 VBZ denotes is
T8752 1697-1699 IN denotes of
T8753 1700-1705 NN denotes Bmp2C
T8754 1706-1707 NN denotes C
T8755 1705-1706 HYPH denotes /
T8756 1728-1733 NNS denotes bones
T8757 1707-1708 : denotes ;
T8758 1709-1714 NN denotes Bmp4C
T8759 1715-1716 NN denotes C
T8760 1714-1715 HYPH denotes /
T8761 1716-1717 : denotes ;
T8762 1718-1722 NN denotes Prx1
T8763 1724-1727 NN denotes cre
T8764 1722-1723 HYPH denotes :
T8765 1723-1724 HYPH denotes :
T8766 1734-1736 IN denotes at
T8767 1737-1742 NN denotes birth
T8768 1746-1750 RBS denotes most
T8769 1751-1758 JJ denotes similar
T8770 1759-1761 IN denotes to
T8771 1762-1769 NN denotes control
T8772 1770-1777 NNS denotes embryos
T8773 1778-1780 IN denotes at
T8774 1781-1786 NN denotes E17.5
T8775 1787-1788 -LRB- denotes (
T8776 1795-1797 NN denotes 5E
T8777 1788-1794 NN denotes Figure
T8778 1797-1798 -RRB- denotes )
T8779 1798-1799 . denotes .
T8780 1799-2031 sentence denotes To differentiate between a simple delay in bone formation in the absence of BMP2 and BMP4 and the inability to form bone without these BMPs, we performed histological analyses in Bmp2C/C; Bmp4C/C; Prx1::cre mice up to 3 wks of age.
T8781 1800-1802 TO denotes To
T8782 1803-1816 VB denotes differentiate
T8783 1944-1953 VBD denotes performed
T8784 1817-1824 IN denotes between
T8785 1825-1826 DT denotes a
T8786 1834-1839 NN denotes delay
T8787 1827-1833 JJ denotes simple
T8788 1840-1842 IN denotes in
T8789 1843-1847 NN denotes bone
T8790 1848-1857 NN denotes formation
T8791 1858-1860 IN denotes in
T8792 1861-1864 DT denotes the
T8793 1865-1872 NN denotes absence
T8794 1873-1875 IN denotes of
T8795 1876-1880 NN denotes BMP2
T8796 1881-1884 CC denotes and
T8797 1885-1889 NN denotes BMP4
T8798 1890-1893 CC denotes and
T8799 1894-1897 DT denotes the
T8800 1898-1907 NN denotes inability
T8801 1908-1910 TO denotes to
T8802 1911-1915 VB denotes form
T8803 1916-1920 NN denotes bone
T8804 1921-1928 IN denotes without
T8805 1929-1934 DT denotes these
T8806 1935-1939 NNS denotes BMPs
T8807 1939-1941 , denotes ,
T8808 1941-1943 PRP denotes we
T8809 1954-1966 JJ denotes histological
T8810 1967-1975 NNS denotes analyses
T8811 1976-1978 IN denotes in
T8812 1979-1984 NN denotes Bmp2C
T8813 1985-1986 NN denotes C
T8814 1984-1985 HYPH denotes /
T8815 2007-2011 NNS denotes mice
T8816 1986-1987 : denotes ;
T8817 1988-1993 NN denotes Bmp4C
T8818 1994-1995 NN denotes C
T8819 1993-1994 HYPH denotes /
T8820 1995-1996 : denotes ;
T8821 1997-2001 NN denotes Prx1
T8822 2003-2006 NN denotes cre
T8823 2001-2002 HYPH denotes :
T8824 2002-2003 HYPH denotes :
T8825 2012-2014 RB denotes up
T8826 2018-2019 CD denotes 3
T8827 2015-2017 IN denotes to
T8828 2020-2023 NNS denotes wks
T8829 2024-2026 IN denotes of
T8830 2027-2030 NN denotes age
T8831 2030-2031 . denotes .
T8832 2031-2192 sentence denotes As shown in Figure 6A through 6E, in the control mice, a bone collar is found adjacent to the zone of late hypertrophic chondrocytes at 1 wk (Figure 6A and 6B).
T8833 2032-2034 IN denotes As
T8834 2035-2040 VBN denotes shown
T8835 2104-2109 VBN denotes found
T8836 2041-2043 IN denotes in
T8837 2044-2050 NN denotes Figure
T8838 2051-2053 NN denotes 6A
T8839 2054-2061 IN denotes through
T8840 2062-2064 NN denotes 6E
T8841 2064-2066 , denotes ,
T8842 2066-2068 IN denotes in
T8843 2069-2072 DT denotes the
T8844 2081-2085 NNS denotes mice
T8845 2073-2080 NN denotes control
T8846 2085-2087 , denotes ,
T8847 2087-2088 DT denotes a
T8848 2094-2100 NN denotes collar
T8849 2089-2093 NN denotes bone
T8850 2101-2103 VBZ denotes is
T8851 2110-2118 JJ denotes adjacent
T8852 2119-2121 IN denotes to
T8853 2122-2125 DT denotes the
T8854 2126-2130 NN denotes zone
T8855 2131-2133 IN denotes of
T8856 2134-2138 JJ denotes late
T8857 2152-2164 NNS denotes chondrocytes
T8858 2139-2151 JJ denotes hypertrophic
T8859 2165-2167 IN denotes at
T8860 2168-2169 CD denotes 1
T8861 2170-2172 NN denotes wk
T8862 2173-2174 -LRB- denotes (
T8863 2181-2183 NN denotes 6A
T8864 2174-2180 NN denotes Figure
T8865 2184-2187 CC denotes and
T8866 2188-2190 NN denotes 6B
T8867 2190-2191 -RRB- denotes )
T8868 2191-2192 . denotes .
T8869 2192-2377 sentence denotes Many osteoblasts line the newly formed cortical bone in the diaphyseal region (Figure 6C, blue arrow), and formation of a secondary ossification center has begun (Figure 6A, red star).
T8870 2193-2197 JJ denotes Many
T8871 2198-2209 NNS denotes osteoblasts
T8872 2210-2214 VBP denotes line
T8873 2215-2218 DT denotes the
T8874 2241-2245 NN denotes bone
T8875 2219-2224 RB denotes newly
T8876 2225-2231 VBN denotes formed
T8877 2232-2240 JJ denotes cortical
T8878 2246-2248 IN denotes in
T8879 2249-2252 DT denotes the
T8880 2264-2270 NN denotes region
T8881 2253-2263 JJ denotes diaphyseal
T8882 2271-2272 -LRB- denotes (
T8883 2288-2293 NN denotes arrow
T8884 2272-2278 NN denotes Figure
T8885 2279-2281 NN denotes 6C
T8886 2281-2283 , denotes ,
T8887 2283-2287 JJ denotes blue
T8888 2293-2294 -RRB- denotes )
T8889 2294-2296 , denotes ,
T8890 2296-2299 CC denotes and
T8891 2300-2309 NN denotes formation
T8892 2349-2354 VBN denotes begun
T8893 2310-2312 IN denotes of
T8894 2313-2314 DT denotes a
T8895 2338-2344 NN denotes center
T8896 2315-2324 JJ denotes secondary
T8897 2325-2337 NN denotes ossification
T8898 2345-2348 VBZ denotes has
T8899 2355-2356 -LRB- denotes (
T8900 2371-2375 NN denotes star
T8901 2356-2362 NN denotes Figure
T8902 2363-2365 NN denotes 6A
T8903 2365-2367 , denotes ,
T8904 2367-2370 JJ denotes red
T8905 2375-2376 -RRB- denotes )
T8906 2376-2377 . denotes .
T8907 2377-2617 sentence denotes At 3 wks of age, formation of the secondary ossification center is complete (Figure 6D, red star), along with robust bone marrow formation (Figure 6D, bm) and deposition of trabecular bone (Figure 6E, pale blue tissue marked by red arrow).
T8908 2378-2380 IN denotes At
T8909 2442-2444 VBZ denotes is
T8910 2381-2382 CD denotes 3
T8911 2383-2386 NNS denotes wks
T8912 2387-2389 IN denotes of
T8913 2390-2393 NN denotes age
T8914 2393-2395 , denotes ,
T8915 2395-2404 NN denotes formation
T8916 2405-2407 IN denotes of
T8917 2408-2411 DT denotes the
T8918 2435-2441 NN denotes center
T8919 2412-2421 JJ denotes secondary
T8920 2422-2434 NN denotes ossification
T8921 2445-2453 JJ denotes complete
T8922 2454-2455 -LRB- denotes (
T8923 2470-2474 NN denotes star
T8924 2455-2461 NN denotes Figure
T8925 2462-2464 NN denotes 6D
T8926 2464-2466 , denotes ,
T8927 2466-2469 JJ denotes red
T8928 2474-2475 -RRB- denotes )
T8929 2475-2477 , denotes ,
T8930 2477-2482 IN denotes along
T8931 2483-2487 IN denotes with
T8932 2488-2494 JJ denotes robust
T8933 2507-2516 NN denotes formation
T8934 2495-2499 NN denotes bone
T8935 2500-2506 NN denotes marrow
T8936 2517-2518 -LRB- denotes (
T8937 2529-2531 NN denotes bm
T8938 2518-2524 NN denotes Figure
T8939 2525-2527 NN denotes 6D
T8940 2527-2529 , denotes ,
T8941 2531-2532 -RRB- denotes )
T8942 2533-2536 CC denotes and
T8943 2537-2547 NN denotes deposition
T8944 2548-2550 IN denotes of
T8945 2551-2561 JJ denotes trabecular
T8946 2562-2566 NN denotes bone
T8947 2567-2568 -LRB- denotes (
T8948 2589-2595 NN denotes tissue
T8949 2568-2574 NN denotes Figure
T8950 2575-2577 NN denotes 6E
T8951 2577-2579 , denotes ,
T8952 2579-2583 JJ denotes pale
T8953 2584-2588 JJ denotes blue
T8954 2596-2602 VBN denotes marked
T8955 2603-2605 IN denotes by
T8956 2606-2609 JJ denotes red
T8957 2610-2615 NN denotes arrow
T8958 2615-2616 -RRB- denotes )
T8959 2616-2617 . denotes .
T8960 2617-2741 sentence denotes In stark contrast, bone formation is not observed in the absence of BMP2 and BMP4 at 1 or 3 wks after birth (Figure 6F–6J).
T8961 2618-2620 IN denotes In
T8962 2659-2667 VBN denotes observed
T8963 2621-2626 JJ denotes stark
T8964 2627-2635 NN denotes contrast
T8965 2635-2637 , denotes ,
T8966 2637-2641 NN denotes bone
T8967 2642-2651 NN denotes formation
T8968 2652-2654 VBZ denotes is
T8969 2655-2658 RB denotes not
T8970 2668-2670 IN denotes in
T8971 2671-2674 DT denotes the
T8972 2675-2682 NN denotes absence
T8973 2683-2685 IN denotes of
T8974 2686-2690 NN denotes BMP2
T8975 2691-2694 CC denotes and
T8976 2695-2699 NN denotes BMP4
T8977 2700-2702 IN denotes at
T8978 2703-2704 CD denotes 1
T8979 2710-2713 NNS denotes wks
T8980 2705-2707 CC denotes or
T8981 2708-2709 CD denotes 3
T8982 2714-2719 IN denotes after
T8983 2720-2725 NN denotes birth
T8984 2726-2727 -LRB- denotes (
T8985 2734-2736 NN denotes 6F
T8986 2727-2733 NN denotes Figure
T8987 2736-2737 SYM denotes –
T8988 2737-2739 NN denotes 6J
T8989 2739-2740 -RRB- denotes )
T8990 2740-2741 . denotes .
T8991 2741-3044 sentence denotes The appearance of the skeletal elements in the double mutants remains similar to E17.5 structures seen in wild-type limbs (Figure 5E), and although there is a bone collar at the site of hypertrophic cartilage (Figure 6G), no bone marrow cavity, trabecular bone, or cortical bone is present (Figure 6F).
T8992 2742-2745 DT denotes The
T8993 2746-2756 NN denotes appearance
T8994 2804-2811 VBZ denotes remains
T8995 2757-2759 IN denotes of
T8996 2760-2763 DT denotes the
T8997 2773-2781 NNS denotes elements
T8998 2764-2772 JJ denotes skeletal
T8999 2782-2784 IN denotes in
T9000 2785-2788 DT denotes the
T9001 2796-2803 NNS denotes mutants
T9002 2789-2795 JJ denotes double
T9003 2812-2819 JJ denotes similar
T9004 2820-2822 IN denotes to
T9005 2823-2828 NN denotes E17.5
T9006 2829-2839 NNS denotes structures
T9007 2840-2844 VBN denotes seen
T9008 2845-2847 IN denotes in
T9009 2848-2852 JJ denotes wild
T9010 2853-2857 NN denotes type
T9011 2852-2853 HYPH denotes -
T9012 2858-2863 NNS denotes limbs
T9013 2864-2865 -LRB- denotes (
T9014 2872-2874 NN denotes 5E
T9015 2865-2871 NN denotes Figure
T9016 2874-2875 -RRB- denotes )
T9017 2875-2877 , denotes ,
T9018 2877-2880 CC denotes and
T9019 2881-2889 IN denotes although
T9020 2896-2898 VBZ denotes is
T9021 2890-2895 EX denotes there
T9022 3021-3023 VBZ denotes is
T9023 2899-2900 DT denotes a
T9024 2906-2912 NN denotes collar
T9025 2901-2905 NN denotes bone
T9026 2913-2915 IN denotes at
T9027 2916-2919 DT denotes the
T9028 2920-2924 NN denotes site
T9029 2925-2927 IN denotes of
T9030 2928-2940 JJ denotes hypertrophic
T9031 2941-2950 NN denotes cartilage
T9032 2951-2952 -LRB- denotes (
T9033 2959-2961 NN denotes 6G
T9034 2952-2958 NN denotes Figure
T9035 2961-2962 -RRB- denotes )
T9036 2962-2964 , denotes ,
T9037 2964-2966 DT denotes no
T9038 2979-2985 NN denotes cavity
T9039 2967-2971 NN denotes bone
T9040 2972-2978 NN denotes marrow
T9041 2985-2987 , denotes ,
T9042 2987-2997 JJ denotes trabecular
T9043 2998-3002 NN denotes bone
T9044 3002-3004 , denotes ,
T9045 3004-3006 CC denotes or
T9046 3007-3015 JJ denotes cortical
T9047 3016-3020 NN denotes bone
T9048 3024-3031 JJ denotes present
T9049 3032-3033 -LRB- denotes (
T9050 3040-3042 NN denotes 6F
T9051 3033-3039 NN denotes Figure
T9052 3042-3043 -RRB- denotes )
T9053 3043-3044 . denotes .
T9054 3044-3375 sentence denotes Many osteoclasts have been recruited to the remaining mineralized cartilage and are actively resorbing this tissue (red asterisks, Figure 6I), so that by 3 wks, all the mineralized cartilage in the diaphyseal region has disappeared, leaving a void where bone formation should have occurred (Figure 6J, also see Figures 6L and S3).
T9055 3045-3049 JJ denotes Many
T9056 3050-3061 NNS denotes osteoclasts
T9057 3072-3081 VBN denotes recruited
T9058 3062-3066 VBP denotes have
T9059 3067-3071 VBN denotes been
T9060 3082-3084 IN denotes to
T9061 3085-3088 DT denotes the
T9062 3111-3120 NN denotes cartilage
T9063 3089-3098 VBG denotes remaining
T9064 3099-3110 VBN denotes mineralized
T9065 3121-3124 CC denotes and
T9066 3125-3128 VBP denotes are
T9067 3138-3147 VBG denotes resorbing
T9068 3129-3137 RB denotes actively
T9069 3148-3152 DT denotes this
T9070 3153-3159 NN denotes tissue
T9071 3160-3161 -LRB- denotes (
T9072 3183-3185 NN denotes 6I
T9073 3161-3164 JJ denotes red
T9074 3165-3174 NNS denotes asterisks
T9075 3174-3176 , denotes ,
T9076 3176-3182 NN denotes Figure
T9077 3185-3186 -RRB- denotes )
T9078 3186-3188 , denotes ,
T9079 3188-3190 IN denotes so
T9080 3265-3276 VBN denotes disappeared
T9081 3191-3195 IN denotes that
T9082 3196-3198 IN denotes by
T9083 3199-3200 CD denotes 3
T9084 3201-3204 NNS denotes wks
T9085 3204-3206 , denotes ,
T9086 3206-3209 PDT denotes all
T9087 3226-3235 NN denotes cartilage
T9088 3210-3213 DT denotes the
T9089 3214-3225 VBN denotes mineralized
T9090 3236-3238 IN denotes in
T9091 3239-3242 DT denotes the
T9092 3254-3260 NN denotes region
T9093 3243-3253 JJ denotes diaphyseal
T9094 3261-3264 VBZ denotes has
T9095 3276-3278 , denotes ,
T9096 3278-3285 VBG denotes leaving
T9097 3286-3287 DT denotes a
T9098 3288-3292 NN denotes void
T9099 3293-3298 WRB denotes where
T9100 3326-3334 VBN denotes occurred
T9101 3299-3303 NN denotes bone
T9102 3304-3313 NN denotes formation
T9103 3314-3320 MD denotes should
T9104 3321-3325 VB denotes have
T9105 3335-3336 -LRB- denotes (
T9106 3343-3345 NN denotes 6J
T9107 3336-3342 NN denotes Figure
T9108 3345-3347 , denotes ,
T9109 3347-3351 RB denotes also
T9110 3352-3355 VBP denotes see
T9111 3356-3363 NNS denotes Figures
T9112 3364-3366 NN denotes 6L
T9113 3367-3370 CC denotes and
T9114 3371-3373 NN denotes S3
T9115 3373-3374 -RRB- denotes )
T9116 3374-3375 . denotes .
T9117 3375-3493 sentence denotes This void is eventually invaded by soft tissues and the adjacent muscle (marked s and m, respectively, in Figure 6J).
T9118 3376-3380 DT denotes This
T9119 3381-3385 NN denotes void
T9120 3400-3407 VBN denotes invaded
T9121 3386-3388 VBZ denotes is
T9122 3389-3399 RB denotes eventually
T9123 3408-3410 IN denotes by
T9124 3411-3415 JJ denotes soft
T9125 3416-3423 NNS denotes tissues
T9126 3424-3427 CC denotes and
T9127 3428-3431 DT denotes the
T9128 3441-3447 NN denotes muscle
T9129 3432-3440 JJ denotes adjacent
T9130 3448-3449 -LRB- denotes (
T9131 3449-3455 VBN denotes marked
T9132 3456-3457 NN denotes s
T9133 3458-3461 CC denotes and
T9134 3462-3463 NN denotes m
T9135 3463-3465 , denotes ,
T9136 3465-3477 RB denotes respectively
T9137 3477-3479 , denotes ,
T9138 3479-3481 IN denotes in
T9139 3482-3488 NN denotes Figure
T9140 3489-3491 NN denotes 6J
T9141 3491-3492 -RRB- denotes )
T9142 3492-3493 . denotes .
T9143 3493-3657 sentence denotes The resorption of bone at 3 wks of age is clearly visible in the proximal femur of mutant animals where a portion of that bone is missing (Figure 6L, black arrow).
T9144 3494-3497 DT denotes The
T9145 3498-3508 NN denotes resorption
T9146 3533-3535 VBZ denotes is
T9147 3509-3511 IN denotes of
T9148 3512-3516 NN denotes bone
T9149 3517-3519 IN denotes at
T9150 3520-3521 CD denotes 3
T9151 3522-3525 NNS denotes wks
T9152 3526-3528 IN denotes of
T9153 3529-3532 NN denotes age
T9154 3536-3543 RB denotes clearly
T9155 3544-3551 JJ denotes visible
T9156 3552-3554 IN denotes in
T9157 3555-3558 DT denotes the
T9158 3568-3573 NN denotes femur
T9159 3559-3567 JJ denotes proximal
T9160 3574-3576 IN denotes of
T9161 3577-3583 NN denotes mutant
T9162 3584-3591 NNS denotes animals
T9163 3592-3597 WRB denotes where
T9164 3621-3623 VBZ denotes is
T9165 3598-3599 DT denotes a
T9166 3600-3607 NN denotes portion
T9167 3608-3610 IN denotes of
T9168 3611-3615 DT denotes that
T9169 3616-3620 NN denotes bone
T9170 3624-3631 JJ denotes missing
T9171 3632-3633 -LRB- denotes (
T9172 3650-3655 NN denotes arrow
T9173 3633-3639 NN denotes Figure
T9174 3640-3642 NN denotes 6L
T9175 3642-3644 , denotes ,
T9176 3644-3649 JJ denotes black
T9177 3655-3656 -RRB- denotes )
T9178 3656-3657 . denotes .
T9179 3657-3843 sentence denotes The inability to complete osteoblast differentiation in the Bmp2C/C; Bmp4C/C; Prx1::cre mice results in strikingly defective limb morphology at 1 wk of age (compare Figure S3G and S3H).
T9180 3658-3661 DT denotes The
T9181 3662-3671 NN denotes inability
T9182 3751-3758 VBZ denotes results
T9183 3672-3674 TO denotes to
T9184 3675-3683 VB denotes complete
T9185 3684-3694 NN denotes osteoblast
T9186 3695-3710 NN denotes differentiation
T9187 3711-3713 IN denotes in
T9188 3714-3717 DT denotes the
T9189 3746-3750 NNS denotes mice
T9190 3718-3723 NN denotes Bmp2C
T9191 3724-3725 NN denotes C
T9192 3723-3724 HYPH denotes /
T9193 3725-3726 : denotes ;
T9194 3727-3732 NN denotes Bmp4C
T9195 3733-3734 NN denotes C
T9196 3732-3733 HYPH denotes /
T9197 3734-3735 : denotes ;
T9198 3736-3740 NN denotes Prx1
T9199 3742-3745 NN denotes cre
T9200 3740-3741 HYPH denotes :
T9201 3741-3742 HYPH denotes :
T9202 3759-3761 IN denotes in
T9203 3762-3772 RB denotes strikingly
T9204 3773-3782 JJ denotes defective
T9205 3788-3798 NN denotes morphology
T9206 3783-3787 NN denotes limb
T9207 3799-3801 IN denotes at
T9208 3802-3803 CD denotes 1
T9209 3804-3806 NN denotes wk
T9210 3807-3809 IN denotes of
T9211 3810-3813 NN denotes age
T9212 3814-3815 -LRB- denotes (
T9213 3815-3822 VB denotes compare
T9214 3823-3829 NN denotes Figure
T9215 3830-3833 NN denotes S3G
T9216 3834-3837 CC denotes and
T9217 3838-3841 NN denotes S3H
T9218 3841-3842 -RRB- denotes )
T9219 3842-3843 . denotes .
R5254 T8409 T8410 compound Bone,formation
R5255 T8410 T8411 nsubj formation,occurs
R5256 T8412 T8411 advmod first,occurs
R5257 T8413 T8411 prep at,occurs
R5258 T8414 T8415 det the,interface
R5259 T8415 T8413 pobj interface,at
R5260 T8416 T8415 prep between,interface
R5261 T8417 T8418 det the,chondrocytes
R5262 T8418 T8416 pobj chondrocytes,between
R5263 T8419 T8418 amod late,chondrocytes
R5264 T8420 T8418 amod hypertrophic,chondrocytes
R5265 T8421 T8418 cc and,chondrocytes
R5266 T8422 T8423 det the,perichondrium
R5267 T8423 T8418 conj perichondrium,chondrocytes
R5268 T8424 T8423 amod surrounding,perichondrium
R5269 T8425 T8415 punct ", ",interface
R5270 T8426 T8427 det a,region
R5271 T8427 T8415 appos region,interface
R5272 T8428 T8427 acl identified,region
R5273 T8429 T8428 prep as,identified
R5274 T8430 T8431 det the,collar
R5275 T8431 T8429 pobj collar,as
R5276 T8432 T8431 compound bone,collar
R5277 T8433 T8411 punct .,occurs
R5278 T8435 T8436 nsubj We,examined
R5279 T8437 T8438 mark whether,initiated
R5280 T8438 T8436 ccomp initiated,examined
R5281 T8439 T8440 det the,program
R5282 T8440 T8438 nsubjpass program,initiated
R5283 T8441 T8440 compound osteogenesis,program
R5284 T8442 T8438 auxpass is,initiated
R5285 T8443 T8438 prep in,initiated
R5286 T8444 T8445 det the,limbs
R5287 T8445 T8443 pobj limbs,in
R5288 T8446 T8447 nmod BMP2,BMP4
R5289 T8447 T8449 npadvmod BMP4,deficient
R5290 T8448 T8447 punct ", ",BMP4
R5291 T8449 T8445 amod deficient,limbs
R5292 T8450 T8449 punct –,deficient
R5293 T8451 T8436 advcl using,examined
R5294 T8452 T8453 amod several,criteria
R5295 T8453 T8451 dobj criteria,using
R5296 T8454 T8453 amod histological,criteria
R5297 T8455 T8454 cc and,histological
R5298 T8456 T8454 conj molecular,histological
R5299 T8457 T8451 punct ", ",using
R5300 T8458 T8459 mark as,described
R5301 T8459 T8451 advcl described,using
R5302 T8460 T8459 advmod below,described
R5303 T8461 T8462 punct (,Figure
R5304 T8462 T8459 parataxis Figure,described
R5305 T8463 T8462 nummod 5,Figure
R5306 T8464 T8462 punct ),Figure
R5307 T8465 T8436 punct .,examined
R5308 T8467 T8468 advcl Adjacent,laid
R5309 T8469 T8467 prep to,Adjacent
R5310 T8470 T8471 det the,cells
R5311 T8471 T8469 pobj cells,to
R5312 T8472 T8471 amod hypertrophic,cells
R5313 T8473 T8468 punct ", ",laid
R5314 T8474 T8475 det a,collar
R5315 T8475 T8468 nsubjpass collar,laid
R5316 T8476 T8475 compound bone,collar
R5317 T8477 T8468 auxpass is,laid
R5318 T8478 T8468 prt down,laid
R5319 T8479 T8468 advmod normally,laid
R5320 T8480 T8468 prep in,laid
R5321 T8481 T8482 det the,absence
R5322 T8482 T8480 pobj absence,in
R5323 T8483 T8482 prep of,absence
R5324 T8484 T8483 pobj BMP2,of
R5325 T8485 T8484 cc and,BMP2
R5326 T8486 T8484 conj BMP4,BMP2
R5327 T8487 T8488 punct (,star
R5328 T8488 T8468 parataxis star,laid
R5329 T8489 T8490 compound Figure,5A
R5330 T8490 T8488 dep 5A,star
R5331 T8491 T8490 cc and,5A
R5332 T8492 T8490 conj 5B,5A
R5333 T8493 T8488 punct ", ",star
R5334 T8494 T8488 amod red,star
R5335 T8495 T8488 punct ),star
R5336 T8496 T8468 punct .,laid
R5337 T8498 T8499 mark As,seen
R5338 T8499 T8502 advcl seen,express
R5339 T8500 T8499 aux can,seen
R5340 T8501 T8499 auxpass be,seen
R5341 T8503 T8499 prep in,seen
R5342 T8504 T8505 amod sagittal,sections
R5343 T8505 T8503 pobj sections,in
R5344 T8506 T8499 prep through,seen
R5345 T8507 T8508 det an,humerus
R5346 T8508 T8506 pobj humerus,through
R5347 T8509 T8508 compound E15.5,humerus
R5348 T8510 T8502 punct ", ",express
R5349 T8511 T8512 det the,cells
R5350 T8512 T8502 nsubj cells,express
R5351 T8513 T8512 acl embedded,cells
R5352 T8514 T8513 prep in,embedded
R5353 T8515 T8516 det the,matrix
R5354 T8516 T8514 pobj matrix,in
R5355 T8517 T8516 amod mineralized,matrix
R5356 T8518 T8519 det the,marker
R5357 T8519 T8502 dobj marker,express
R5358 T8520 T8519 compound osteoblast,marker
R5359 T8521 T8519 appos Col,marker
R5360 T8522 T8521 nummod I,Col
R5361 T8523 T8502 prep as,express
R5362 T8524 T8523 amod normal,as
R5363 T8525 T8526 punct (,5C
R5364 T8526 T8502 parataxis 5C,express
R5365 T8527 T8526 compound Figure,5C
R5366 T8528 T8526 cc and,5C
R5367 T8529 T8526 conj 5D,5C
R5368 T8530 T8526 punct ),5C
R5369 T8531 T8502 punct .,express
R5370 T8533 T8534 prep By,undergoes
R5371 T8535 T8533 pobj E17.5,By
R5372 T8536 T8534 punct ", ",undergoes
R5373 T8537 T8538 det the,cartilage
R5374 T8538 T8534 nsubj cartilage,undergoes
R5375 T8539 T8538 amod mineralized,cartilage
R5376 T8540 T8541 dep that,makes
R5377 T8541 T8538 relcl makes,cartilage
R5378 T8542 T8541 prt up,makes
R5379 T8543 T8544 det the,zone
R5380 T8544 T8541 dobj zone,makes
R5381 T8545 T8544 amod late,zone
R5382 T8546 T8544 amod hypertrophic,zone
R5383 T8547 T8544 prep of,zone
R5384 T8548 T8549 det the,plate
R5385 T8549 T8547 pobj plate,of
R5386 T8550 T8549 compound growth,plate
R5387 T8551 T8534 advmod normally,undergoes
R5388 T8552 T8534 dobj removal,undergoes
R5389 T8553 T8552 prep by,removal
R5390 T8554 T8553 pobj osteoclasts,by
R5391 T8555 T8556 punct (,arrows
R5392 T8556 T8534 parataxis arrows,undergoes
R5393 T8557 T8558 compound Figure,5G
R5394 T8558 T8556 dep 5G,arrows
R5395 T8559 T8556 punct ", ",arrows
R5396 T8560 T8561 amod brown,stained
R5397 T8561 T8563 amod stained,cells
R5398 T8562 T8561 punct -,stained
R5399 T8563 T8556 dep cells,arrows
R5400 T8564 T8556 punct ", ",arrows
R5401 T8565 T8556 amod red,arrows
R5402 T8566 T8556 punct ),arrows
R5403 T8567 T8534 punct ", ",undergoes
R5404 T8568 T8534 advcl resulting,undergoes
R5405 T8569 T8568 prep in,resulting
R5406 T8570 T8571 det the,formation
R5407 T8571 T8569 pobj formation,in
R5408 T8572 T8571 prep of,formation
R5409 T8573 T8574 det a,cavity
R5410 T8574 T8572 pobj cavity,of
R5411 T8575 T8576 compound bone,marrow
R5412 T8576 T8574 compound marrow,cavity
R5413 T8577 T8578 punct (,arrow
R5414 T8578 T8534 parataxis arrow,undergoes
R5415 T8579 T8578 amod red,arrow
R5416 T8580 T8578 prep in,arrow
R5417 T8581 T8582 compound Figure,5E
R5418 T8582 T8580 pobj 5E,in
R5419 T8583 T8582 cc and,5E
R5420 T8584 T8582 conj 5I,5E
R5421 T8585 T8578 punct ", ",arrow
R5422 T8586 T8578 advcl see,arrow
R5423 T8587 T8586 advmod also,see
R5424 T8588 T8586 dobj Figure,see
R5425 T8589 T8588 nummod 6,Figure
R5426 T8590 T8578 punct ),arrow
R5427 T8591 T8534 punct .,undergoes
R5428 T8593 T8594 compound Osteoprogenitor,cells
R5429 T8594 T8595 nsubj cells,populate
R5430 T8596 T8594 prep from,cells
R5431 T8597 T8598 compound bone,region
R5432 T8598 T8596 pobj region,from
R5433 T8599 T8598 compound collar,region
R5434 T8600 T8595 advmod now,populate
R5435 T8601 T8602 det this,site
R5436 T8602 T8595 dobj site,populate
R5437 T8603 T8595 cc and,populate
R5438 T8604 T8595 conj deposit,populate
R5439 T8605 T8604 dobj osteoid,deposit
R5440 T8606 T8595 punct ", ",populate
R5441 T8607 T8595 advcl forming,populate
R5442 T8608 T8609 det the,bone
R5443 T8609 T8607 dobj bone,forming
R5444 T8610 T8609 amod trabecular,bone
R5445 T8611 T8609 prep in,bone
R5446 T8612 T8613 det the,cavity
R5447 T8613 T8611 pobj cavity,in
R5448 T8614 T8613 compound bone,cavity
R5449 T8615 T8613 compound marrow,cavity
R5450 T8616 T8617 punct (,arrow
R5451 T8617 T8613 parataxis arrow,cavity
R5452 T8618 T8619 compound Figure,6E
R5453 T8619 T8617 dep 6E,arrow
R5454 T8620 T8617 punct ", ",arrow
R5455 T8621 T8617 amod red,arrow
R5456 T8622 T8617 punct ),arrow
R5457 T8623 T8613 cc and,cavity
R5458 T8624 T8625 amod cortical,bone
R5459 T8625 T8613 conj bone,cavity
R5460 T8626 T8607 prep at,forming
R5461 T8627 T8626 pobj birth,at
R5462 T8628 T8629 punct (,asterisk
R5463 T8629 T8595 parataxis asterisk,populate
R5464 T8630 T8631 compound Figure,5I
R5465 T8631 T8629 dep 5I,asterisk
R5466 T8632 T8629 punct ", ",asterisk
R5467 T8633 T8629 punct ),asterisk
R5468 T8634 T8595 punct .,populate
R5469 T8636 T8637 prep In,is
R5470 T8638 T8636 pobj contrast,In
R5471 T8639 T8637 punct ", ",is
R5472 T8640 T8637 prep in,is
R5473 T8641 T8642 compound E17.5,limbs
R5474 T8642 T8640 pobj limbs,in
R5475 T8643 T8642 amod deficient,limbs
R5476 T8644 T8643 prep in,deficient
R5477 T8645 T8644 pobj BMP2,in
R5478 T8646 T8645 cc and,BMP2
R5479 T8647 T8645 conj BMP4,BMP2
R5480 T8648 T8637 punct ", ",is
R5481 T8649 T8637 expl there,is
R5482 T8650 T8651 det an,delay
R5483 T8651 T8637 attr delay,is
R5484 T8652 T8651 amod overall,delay
R5485 T8653 T8651 prep in,delay
R5486 T8654 T8655 det the,process
R5487 T8655 T8653 pobj process,in
R5488 T8656 T8655 amod normal,process
R5489 T8657 T8655 amod endochondral,process
R5490 T8658 T8659 punct (,5F
R5491 T8659 T8637 parataxis 5F,is
R5492 T8660 T8659 compound Figure,5F
R5493 T8661 T8659 punct ),5F
R5494 T8662 T8637 punct .,is
R5495 T8664 T8665 mark While,occurs
R5496 T8665 T8667 advcl occurs,recruited
R5497 T8666 T8665 nsubj vascularization,occurs
R5498 T8668 T8665 prep in,occurs
R5499 T8669 T8670 nmod Bmp2C,C
R5500 T8670 T8672 nmod C,forelimbs
R5501 T8671 T8670 punct /,C
R5502 T8672 T8668 pobj forelimbs,in
R5503 T8673 T8670 punct ;,C
R5504 T8674 T8675 compound Bmp4C,C
R5505 T8675 T8670 appos C,C
R5506 T8676 T8675 punct /,C
R5507 T8677 T8670 punct ;,C
R5508 T8678 T8679 compound Prx1,cre
R5509 T8679 T8670 appos cre,C
R5510 T8680 T8679 punct :,cre
R5511 T8681 T8679 punct :,cre
R5512 T8682 T8667 punct ", ",recruited
R5513 T8683 T8684 amod few,osteoclasts
R5514 T8684 T8667 nsubjpass osteoclasts,recruited
R5515 T8685 T8667 auxpass are,recruited
R5516 T8686 T8667 prep to,recruited
R5517 T8687 T8688 det the,cartilage
R5518 T8688 T8686 pobj cartilage,to
R5519 T8689 T8688 amod mineralized,cartilage
R5520 T8690 T8691 punct (,arrows
R5521 T8691 T8667 parataxis arrows,recruited
R5522 T8692 T8691 advcl compare,arrows
R5523 T8693 T8694 compound Figure,5G
R5524 T8694 T8692 dobj 5G,compare
R5525 T8695 T8694 cc and,5G
R5526 T8696 T8697 compound Figure,5H
R5527 T8697 T8694 conj 5H,5G
R5528 T8698 T8691 punct ", ",arrows
R5529 T8699 T8691 amod red,arrows
R5530 T8700 T8691 punct ),arrows
R5531 T8701 T8667 punct ", ",recruited
R5532 T8702 T8667 advcl resulting,recruited
R5533 T8703 T8702 prep in,resulting
R5534 T8704 T8705 det a,delay
R5535 T8705 T8703 pobj delay,in
R5536 T8706 T8705 prep in,delay
R5537 T8707 T8708 compound bone,marrow
R5538 T8708 T8709 compound marrow,formation
R5539 T8709 T8706 pobj formation,in
R5540 T8710 T8709 compound cavity,formation
R5541 T8711 T8702 prep in,resulting
R5542 T8712 T8713 det the,absence
R5543 T8713 T8711 pobj absence,in
R5544 T8714 T8713 prep of,absence
R5545 T8715 T8714 pobj BMP2,of
R5546 T8716 T8715 cc and,BMP2
R5547 T8717 T8715 conj BMP4,BMP2
R5548 T8718 T8667 punct .,recruited
R5549 T8720 T8721 prep In,started
R5550 T8722 T8720 pobj fact,In
R5551 T8723 T8721 punct ", ",started
R5552 T8724 T8725 compound bone,marrow
R5553 T8725 T8726 compound marrow,formation
R5554 T8726 T8721 nsubj formation,started
R5555 T8727 T8726 cc and,formation
R5556 T8728 T8729 amod trabecular,formation
R5557 T8729 T8726 conj formation,formation
R5558 T8730 T8729 compound bone,formation
R5559 T8731 T8721 aux have,started
R5560 T8732 T8721 neg not,started
R5561 T8733 T8721 advmod yet,started
R5562 T8734 T8721 prep at,started
R5563 T8735 T8734 pobj birth,at
R5564 T8736 T8721 prep in,started
R5565 T8737 T8738 det the,absence
R5566 T8738 T8736 pobj absence,in
R5567 T8739 T8738 prep of,absence
R5568 T8740 T8739 pobj BMP2,of
R5569 T8741 T8740 cc and,BMP2
R5570 T8742 T8740 conj BMP4,BMP2
R5571 T8743 T8744 punct (,5J
R5572 T8744 T8721 parataxis 5J,started
R5573 T8745 T8744 compound Figure,5J
R5574 T8746 T8744 punct ),5J
R5575 T8747 T8721 punct ", ",started
R5576 T8748 T8721 cc and,started
R5577 T8749 T8750 det the,morphology
R5578 T8750 T8751 nsubj morphology,is
R5579 T8751 T8721 conj is,started
R5580 T8752 T8750 prep of,morphology
R5581 T8753 T8754 nmod Bmp2C,C
R5582 T8754 T8756 nmod C,bones
R5583 T8755 T8754 punct /,C
R5584 T8756 T8752 pobj bones,of
R5585 T8757 T8754 punct ;,C
R5586 T8758 T8759 compound Bmp4C,C
R5587 T8759 T8754 appos C,C
R5588 T8760 T8759 punct /,C
R5589 T8761 T8754 punct ;,C
R5590 T8762 T8763 compound Prx1,cre
R5591 T8763 T8754 appos cre,C
R5592 T8764 T8763 punct :,cre
R5593 T8765 T8763 punct :,cre
R5594 T8766 T8756 prep at,bones
R5595 T8767 T8766 pobj birth,at
R5596 T8768 T8769 advmod most,similar
R5597 T8769 T8751 acomp similar,is
R5598 T8770 T8769 prep to,similar
R5599 T8771 T8772 compound control,embryos
R5600 T8772 T8770 pobj embryos,to
R5601 T8773 T8772 prep at,embryos
R5602 T8774 T8773 pobj E17.5,at
R5603 T8775 T8776 punct (,5E
R5604 T8776 T8721 parataxis 5E,started
R5605 T8777 T8776 compound Figure,5E
R5606 T8778 T8776 punct ),5E
R5607 T8779 T8721 punct .,started
R5608 T8781 T8782 aux To,differentiate
R5609 T8782 T8783 advcl differentiate,performed
R5610 T8784 T8782 prep between,differentiate
R5611 T8785 T8786 det a,delay
R5612 T8786 T8784 pobj delay,between
R5613 T8787 T8786 amod simple,delay
R5614 T8788 T8786 prep in,delay
R5615 T8789 T8790 compound bone,formation
R5616 T8790 T8788 pobj formation,in
R5617 T8791 T8786 prep in,delay
R5618 T8792 T8793 det the,absence
R5619 T8793 T8791 pobj absence,in
R5620 T8794 T8793 prep of,absence
R5621 T8795 T8794 pobj BMP2,of
R5622 T8796 T8795 cc and,BMP2
R5623 T8797 T8795 conj BMP4,BMP2
R5624 T8798 T8786 cc and,delay
R5625 T8799 T8800 det the,inability
R5626 T8800 T8786 conj inability,delay
R5627 T8801 T8802 aux to,form
R5628 T8802 T8800 acl form,inability
R5629 T8803 T8802 dobj bone,form
R5630 T8804 T8803 prep without,bone
R5631 T8805 T8806 det these,BMPs
R5632 T8806 T8804 pobj BMPs,without
R5633 T8807 T8783 punct ", ",performed
R5634 T8808 T8783 nsubj we,performed
R5635 T8809 T8810 amod histological,analyses
R5636 T8810 T8783 dobj analyses,performed
R5637 T8811 T8783 prep in,performed
R5638 T8812 T8813 nmod Bmp2C,C
R5639 T8813 T8815 nmod C,mice
R5640 T8814 T8813 punct /,C
R5641 T8815 T8811 pobj mice,in
R5642 T8816 T8813 punct ;,C
R5643 T8817 T8818 compound Bmp4C,C
R5644 T8818 T8813 appos C,C
R5645 T8819 T8818 punct /,C
R5646 T8820 T8813 punct ;,C
R5647 T8821 T8822 compound Prx1,cre
R5648 T8822 T8813 appos cre,C
R5649 T8823 T8822 punct :,cre
R5650 T8824 T8822 punct :,cre
R5651 T8825 T8826 advmod up,3
R5652 T8826 T8828 nummod 3,wks
R5653 T8827 T8826 quantmod to,3
R5654 T8828 T8815 npadvmod wks,mice
R5655 T8829 T8828 prep of,wks
R5656 T8830 T8829 pobj age,of
R5657 T8831 T8783 punct .,performed
R5658 T8833 T8834 mark As,shown
R5659 T8834 T8835 advcl shown,found
R5660 T8836 T8834 prep in,shown
R5661 T8837 T8838 compound Figure,6A
R5662 T8838 T8836 pobj 6A,in
R5663 T8839 T8838 prep through,6A
R5664 T8840 T8839 pobj 6E,through
R5665 T8841 T8835 punct ", ",found
R5666 T8842 T8835 prep in,found
R5667 T8843 T8844 det the,mice
R5668 T8844 T8842 pobj mice,in
R5669 T8845 T8844 compound control,mice
R5670 T8846 T8835 punct ", ",found
R5671 T8847 T8848 det a,collar
R5672 T8848 T8835 nsubjpass collar,found
R5673 T8849 T8848 compound bone,collar
R5674 T8850 T8835 auxpass is,found
R5675 T8851 T8835 oprd adjacent,found
R5676 T8852 T8851 prep to,adjacent
R5677 T8853 T8854 det the,zone
R5678 T8854 T8852 pobj zone,to
R5679 T8855 T8854 prep of,zone
R5680 T8856 T8857 amod late,chondrocytes
R5681 T8857 T8855 pobj chondrocytes,of
R5682 T8858 T8857 amod hypertrophic,chondrocytes
R5683 T8859 T8835 prep at,found
R5684 T8860 T8861 nummod 1,wk
R5685 T8861 T8859 pobj wk,at
R5686 T8862 T8863 punct (,6A
R5687 T8863 T8835 parataxis 6A,found
R5688 T8864 T8863 compound Figure,6A
R5689 T8865 T8863 cc and,6A
R5690 T8866 T8863 conj 6B,6A
R5691 T8867 T8863 punct ),6A
R5692 T8868 T8835 punct .,found
R5693 T8870 T8871 amod Many,osteoblasts
R5694 T8871 T8872 nsubj osteoblasts,line
R5695 T8873 T8874 det the,bone
R5696 T8874 T8872 dobj bone,line
R5697 T8875 T8876 advmod newly,formed
R5698 T8876 T8874 amod formed,bone
R5699 T8877 T8874 amod cortical,bone
R5700 T8878 T8874 prep in,bone
R5701 T8879 T8880 det the,region
R5702 T8880 T8878 pobj region,in
R5703 T8881 T8880 amod diaphyseal,region
R5704 T8882 T8883 punct (,arrow
R5705 T8883 T8872 parataxis arrow,line
R5706 T8884 T8885 compound Figure,6C
R5707 T8885 T8883 dep 6C,arrow
R5708 T8886 T8883 punct ", ",arrow
R5709 T8887 T8883 amod blue,arrow
R5710 T8888 T8883 punct ),arrow
R5711 T8889 T8872 punct ", ",line
R5712 T8890 T8872 cc and,line
R5713 T8891 T8892 nsubj formation,begun
R5714 T8892 T8872 conj begun,line
R5715 T8893 T8891 prep of,formation
R5716 T8894 T8895 det a,center
R5717 T8895 T8893 pobj center,of
R5718 T8896 T8895 amod secondary,center
R5719 T8897 T8895 compound ossification,center
R5720 T8898 T8892 aux has,begun
R5721 T8899 T8900 punct (,star
R5722 T8900 T8892 parataxis star,begun
R5723 T8901 T8902 compound Figure,6A
R5724 T8902 T8900 dep 6A,star
R5725 T8903 T8900 punct ", ",star
R5726 T8904 T8900 amod red,star
R5727 T8905 T8900 punct ),star
R5728 T8906 T8892 punct .,begun
R5729 T8908 T8909 prep At,is
R5730 T8910 T8911 nummod 3,wks
R5731 T8911 T8908 pobj wks,At
R5732 T8912 T8911 prep of,wks
R5733 T8913 T8912 pobj age,of
R5734 T8914 T8909 punct ", ",is
R5735 T8915 T8909 nsubj formation,is
R5736 T8916 T8915 prep of,formation
R5737 T8917 T8918 det the,center
R5738 T8918 T8916 pobj center,of
R5739 T8919 T8918 amod secondary,center
R5740 T8920 T8918 compound ossification,center
R5741 T8921 T8909 acomp complete,is
R5742 T8922 T8923 punct (,star
R5743 T8923 T8909 parataxis star,is
R5744 T8924 T8925 compound Figure,6D
R5745 T8925 T8923 dep 6D,star
R5746 T8926 T8923 punct ", ",star
R5747 T8927 T8923 amod red,star
R5748 T8928 T8923 punct ),star
R5749 T8929 T8909 punct ", ",is
R5750 T8930 T8909 prep along,is
R5751 T8931 T8930 prep with,along
R5752 T8932 T8933 amod robust,formation
R5753 T8933 T8931 pobj formation,with
R5754 T8934 T8935 compound bone,marrow
R5755 T8935 T8933 compound marrow,formation
R5756 T8936 T8937 punct (,bm
R5757 T8937 T8933 parataxis bm,formation
R5758 T8938 T8939 compound Figure,6D
R5759 T8939 T8937 dep 6D,bm
R5760 T8940 T8937 punct ", ",bm
R5761 T8941 T8937 punct ),bm
R5762 T8942 T8933 cc and,formation
R5763 T8943 T8933 conj deposition,formation
R5764 T8944 T8943 prep of,deposition
R5765 T8945 T8946 amod trabecular,bone
R5766 T8946 T8944 pobj bone,of
R5767 T8947 T8948 punct (,tissue
R5768 T8948 T8909 parataxis tissue,is
R5769 T8949 T8950 compound Figure,6E
R5770 T8950 T8948 dep 6E,tissue
R5771 T8951 T8948 punct ", ",tissue
R5772 T8952 T8948 amod pale,tissue
R5773 T8953 T8948 amod blue,tissue
R5774 T8954 T8948 acl marked,tissue
R5775 T8955 T8954 agent by,marked
R5776 T8956 T8957 amod red,arrow
R5777 T8957 T8955 pobj arrow,by
R5778 T8958 T8948 punct ),tissue
R5779 T8959 T8909 punct .,is
R5780 T8961 T8962 prep In,observed
R5781 T8963 T8964 amod stark,contrast
R5782 T8964 T8961 pobj contrast,In
R5783 T8965 T8962 punct ", ",observed
R5784 T8966 T8967 compound bone,formation
R5785 T8967 T8962 nsubjpass formation,observed
R5786 T8968 T8962 auxpass is,observed
R5787 T8969 T8962 neg not,observed
R5788 T8970 T8962 prep in,observed
R5789 T8971 T8972 det the,absence
R5790 T8972 T8970 pobj absence,in
R5791 T8973 T8972 prep of,absence
R5792 T8974 T8973 pobj BMP2,of
R5793 T8975 T8974 cc and,BMP2
R5794 T8976 T8974 conj BMP4,BMP2
R5795 T8977 T8962 prep at,observed
R5796 T8978 T8979 nummod 1,wks
R5797 T8979 T8977 pobj wks,at
R5798 T8980 T8978 cc or,1
R5799 T8981 T8978 conj 3,1
R5800 T8982 T8979 prep after,wks
R5801 T8983 T8982 pobj birth,after
R5802 T8984 T8985 punct (,6F
R5803 T8985 T8962 parataxis 6F,observed
R5804 T8986 T8985 compound Figure,6F
R5805 T8987 T8988 punct –,6J
R5806 T8988 T8985 prep 6J,6F
R5807 T8989 T8985 punct ),6F
R5808 T8990 T8962 punct .,observed
R5809 T8992 T8993 det The,appearance
R5810 T8993 T8994 nsubj appearance,remains
R5811 T8995 T8993 prep of,appearance
R5812 T8996 T8997 det the,elements
R5813 T8997 T8995 pobj elements,of
R5814 T8998 T8997 amod skeletal,elements
R5815 T8999 T8993 prep in,appearance
R5816 T9000 T9001 det the,mutants
R5817 T9001 T8999 pobj mutants,in
R5818 T9002 T9001 amod double,mutants
R5819 T9003 T8994 acomp similar,remains
R5820 T9004 T9003 prep to,similar
R5821 T9005 T9006 compound E17.5,structures
R5822 T9006 T9004 pobj structures,to
R5823 T9007 T9006 acl seen,structures
R5824 T9008 T9007 prep in,seen
R5825 T9009 T9010 amod wild,type
R5826 T9010 T9012 compound type,limbs
R5827 T9011 T9010 punct -,type
R5828 T9012 T9008 pobj limbs,in
R5829 T9013 T9014 punct (,5E
R5830 T9014 T9007 parataxis 5E,seen
R5831 T9015 T9014 compound Figure,5E
R5832 T9016 T9014 punct ),5E
R5833 T9017 T8994 punct ", ",remains
R5834 T9018 T8994 cc and,remains
R5835 T9019 T9020 mark although,is
R5836 T9020 T9022 advcl is,is
R5837 T9021 T9020 expl there,is
R5838 T9022 T8994 conj is,remains
R5839 T9023 T9024 det a,collar
R5840 T9024 T9020 attr collar,is
R5841 T9025 T9024 compound bone,collar
R5842 T9026 T9020 prep at,is
R5843 T9027 T9028 det the,site
R5844 T9028 T9026 pobj site,at
R5845 T9029 T9028 prep of,site
R5846 T9030 T9031 amod hypertrophic,cartilage
R5847 T9031 T9029 pobj cartilage,of
R5848 T9032 T9033 punct (,6G
R5849 T9033 T9020 parataxis 6G,is
R5850 T9034 T9033 compound Figure,6G
R5851 T9035 T9033 punct ),6G
R5852 T9036 T9022 punct ", ",is
R5853 T9037 T9038 det no,cavity
R5854 T9038 T9022 nsubj cavity,is
R5855 T9039 T9040 compound bone,marrow
R5856 T9040 T9038 compound marrow,cavity
R5857 T9041 T9038 punct ", ",cavity
R5858 T9042 T9043 amod trabecular,bone
R5859 T9043 T9038 conj bone,cavity
R5860 T9044 T9043 punct ", ",bone
R5861 T9045 T9043 cc or,bone
R5862 T9046 T9047 amod cortical,bone
R5863 T9047 T9043 conj bone,bone
R5864 T9048 T9022 acomp present,is
R5865 T9049 T9050 punct (,6F
R5866 T9050 T9022 parataxis 6F,is
R5867 T9051 T9050 compound Figure,6F
R5868 T9052 T9050 punct ),6F
R5869 T9053 T9022 punct .,is
R5870 T9055 T9056 amod Many,osteoclasts
R5871 T9056 T9057 nsubjpass osteoclasts,recruited
R5872 T9058 T9057 aux have,recruited
R5873 T9059 T9057 auxpass been,recruited
R5874 T9060 T9057 prep to,recruited
R5875 T9061 T9062 det the,cartilage
R5876 T9062 T9060 pobj cartilage,to
R5877 T9063 T9062 amod remaining,cartilage
R5878 T9064 T9062 amod mineralized,cartilage
R5879 T9065 T9057 cc and,recruited
R5880 T9066 T9067 aux are,resorbing
R5881 T9067 T9057 conj resorbing,recruited
R5882 T9068 T9067 advmod actively,resorbing
R5883 T9069 T9070 det this,tissue
R5884 T9070 T9067 dobj tissue,resorbing
R5885 T9071 T9072 punct (,6I
R5886 T9072 T9067 parataxis 6I,resorbing
R5887 T9073 T9074 amod red,asterisks
R5888 T9074 T9072 dep asterisks,6I
R5889 T9075 T9072 punct ", ",6I
R5890 T9076 T9072 compound Figure,6I
R5891 T9077 T9072 punct ),6I
R5892 T9078 T9057 punct ", ",recruited
R5893 T9079 T9080 mark so,disappeared
R5894 T9080 T9057 advcl disappeared,recruited
R5895 T9081 T9080 mark that,disappeared
R5896 T9082 T9080 prep by,disappeared
R5897 T9083 T9084 nummod 3,wks
R5898 T9084 T9082 pobj wks,by
R5899 T9085 T9080 punct ", ",disappeared
R5900 T9086 T9087 predet all,cartilage
R5901 T9087 T9080 nsubj cartilage,disappeared
R5902 T9088 T9087 det the,cartilage
R5903 T9089 T9087 amod mineralized,cartilage
R5904 T9090 T9087 prep in,cartilage
R5905 T9091 T9092 det the,region
R5906 T9092 T9090 pobj region,in
R5907 T9093 T9092 amod diaphyseal,region
R5908 T9094 T9080 aux has,disappeared
R5909 T9095 T9080 punct ", ",disappeared
R5910 T9096 T9080 advcl leaving,disappeared
R5911 T9097 T9098 det a,void
R5912 T9098 T9096 dobj void,leaving
R5913 T9099 T9100 advmod where,occurred
R5914 T9100 T9098 relcl occurred,void
R5915 T9101 T9102 compound bone,formation
R5916 T9102 T9100 nsubj formation,occurred
R5917 T9103 T9100 aux should,occurred
R5918 T9104 T9100 aux have,occurred
R5919 T9105 T9106 punct (,6J
R5920 T9106 T9057 parataxis 6J,recruited
R5921 T9107 T9106 compound Figure,6J
R5922 T9108 T9106 punct ", ",6J
R5923 T9109 T9110 advmod also,see
R5924 T9110 T9106 advcl see,6J
R5925 T9111 T9112 compound Figures,6L
R5926 T9112 T9110 dobj 6L,see
R5927 T9113 T9112 cc and,6L
R5928 T9114 T9112 conj S3,6L
R5929 T9115 T9106 punct ),6J
R5930 T9116 T9057 punct .,recruited
R5931 T9118 T9119 det This,void
R5932 T9119 T9120 nsubjpass void,invaded
R5933 T9121 T9120 auxpass is,invaded
R5934 T9122 T9120 advmod eventually,invaded
R5935 T9123 T9120 agent by,invaded
R5936 T9124 T9125 amod soft,tissues
R5937 T9125 T9123 pobj tissues,by
R5938 T9126 T9125 cc and,tissues
R5939 T9127 T9128 det the,muscle
R5940 T9128 T9125 conj muscle,tissues
R5941 T9129 T9128 amod adjacent,muscle
R5942 T9130 T9128 punct (,muscle
R5943 T9131 T9128 acl marked,muscle
R5944 T9132 T9131 oprd s,marked
R5945 T9133 T9132 cc and,s
R5946 T9134 T9132 conj m,s
R5947 T9135 T9131 punct ", ",marked
R5948 T9136 T9131 advmod respectively,marked
R5949 T9137 T9131 punct ", ",marked
R5950 T9138 T9131 prep in,marked
R5951 T9139 T9140 compound Figure,6J
R5952 T9140 T9138 pobj 6J,in
R5953 T9141 T9120 punct ),invaded
R5954 T9142 T9120 punct .,invaded
R5955 T9144 T9145 det The,resorption
R5956 T9145 T9146 nsubj resorption,is
R5957 T9147 T9145 prep of,resorption
R5958 T9148 T9147 pobj bone,of
R5959 T9149 T9145 prep at,resorption
R5960 T9150 T9151 nummod 3,wks
R5961 T9151 T9149 pobj wks,at
R5962 T9152 T9151 prep of,wks
R5963 T9153 T9152 pobj age,of
R5964 T9154 T9155 advmod clearly,visible
R5965 T9155 T9146 acomp visible,is
R5966 T9156 T9146 prep in,is
R5967 T9157 T9158 det the,femur
R5968 T9158 T9156 pobj femur,in
R5969 T9159 T9158 amod proximal,femur
R5970 T9160 T9158 prep of,femur
R5971 T9161 T9162 compound mutant,animals
R5972 T9162 T9160 pobj animals,of
R5973 T9163 T9164 advmod where,is
R5974 T9164 T9158 relcl is,femur
R5975 T9165 T9166 det a,portion
R5976 T9166 T9164 nsubj portion,is
R5977 T9167 T9166 prep of,portion
R5978 T9168 T9169 det that,bone
R5979 T9169 T9167 pobj bone,of
R5980 T9170 T9164 acomp missing,is
R5981 T9171 T9172 punct (,arrow
R5982 T9172 T9146 parataxis arrow,is
R5983 T9173 T9174 compound Figure,6L
R5984 T9174 T9172 dep 6L,arrow
R5985 T9175 T9172 punct ", ",arrow
R5986 T9176 T9172 amod black,arrow
R5987 T9177 T9172 punct ),arrow
R5988 T9178 T9146 punct .,is
R5989 T9180 T9181 det The,inability
R5990 T9181 T9182 nsubj inability,results
R5991 T9183 T9184 aux to,complete
R5992 T9184 T9181 acl complete,inability
R5993 T9185 T9186 compound osteoblast,differentiation
R5994 T9186 T9184 dobj differentiation,complete
R5995 T9187 T9184 prep in,complete
R5996 T9188 T9189 det the,mice
R5997 T9189 T9187 pobj mice,in
R5998 T9190 T9191 nmod Bmp2C,C
R5999 T9191 T9189 nmod C,mice
R6000 T9192 T9191 punct /,C
R6001 T9193 T9191 punct ;,C
R6002 T9194 T9195 compound Bmp4C,C
R6003 T9195 T9191 appos C,C
R6004 T9196 T9195 punct /,C
R6005 T9197 T9191 punct ;,C
R6006 T9198 T9199 compound Prx1,cre
R6007 T9199 T9191 appos cre,C
R6008 T9200 T9199 punct :,cre
R6009 T9201 T9199 punct :,cre
R6010 T9202 T9182 prep in,results
R6011 T9203 T9204 advmod strikingly,defective
R6012 T9204 T9205 amod defective,morphology
R6013 T9205 T9202 pobj morphology,in
R6014 T9206 T9205 compound limb,morphology
R6015 T9207 T9205 prep at,morphology
R6016 T9208 T9209 nummod 1,wk
R6017 T9209 T9207 pobj wk,at
R6018 T9210 T9209 prep of,wk
R6019 T9211 T9210 pobj age,of
R6020 T9212 T9213 punct (,compare
R6021 T9213 T9182 parataxis compare,results
R6022 T9214 T9215 compound Figure,S3G
R6023 T9215 T9213 dobj S3G,compare
R6024 T9216 T9215 cc and,S3G
R6025 T9217 T9215 conj S3H,S3G
R6026 T9218 T9213 punct ),compare
R6027 T9219 T9182 punct .,results

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T8224 0-4 UBERON_EXT:bone_element_or_tissue denotes Bone
T8225 0-14 GO_EXT:bone_development_or_ossification denotes Bone formation
T8226 62-87 CL:0000743 denotes hypertrophic chondrocytes
T8227 108-121 UBERON:0002222 denotes perichondrium
T8228 150-154 UBERON_EXT:bone_element_or_tissue denotes bone
T8229 187-199 GO:0001503 denotes osteogenesis
T8230 228-232 PR_EXT:000000164 denotes BMP2
T8231 234-238 PR_EXT:000000165 denotes BMP4
T8232 249-254 UBERON:0002101 denotes limbs
T8233 286-295 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T8234 366-371 CL_GO_EXT:cell denotes cells
T8235 375-379 UBERON_EXT:bone_element_or_tissue denotes bone
T8236 427-431 PR_EXT:000000164 denotes BMP2
T8237 436-440 PR_EXT:000000165 denotes BMP4
T8238 524-531 UBERON:0000976 denotes humerus
T8239 537-542 CL_GO_EXT:cell denotes cells
T8240 571-577 GO:0031012 denotes matrix
T8241 578-585 GO:0010467 denotes express
T8242 590-600 CL:0000062 denotes osteoblast
T8243 601-607 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T8244 608-611 CHEBI_PR_EXT:collagen denotes Col
T8245 608-613 PR_EXT:000003263 denotes Col I
T8246 658-679 UBERON:4000088 denotes mineralized cartilage
T8247 703-723 _FRAGMENT denotes hypertrophic zone of
T8248 728-740 UBERON:0006772 denotes growth plate
T8249 728-734 GO_EXT:biological_growth_entity_or_process denotes growth
T8250 771-782 CL:0000092 denotes osteoclasts
T8251 809-814 CL_GO_EXT:cell denotes cells
T8252 861-879 UBERON:0002484 denotes bone marrow cavity
T8253 932-953 CL:0007010 denotes Osteoprogenitor cells
T8254 948-953 CL_GO_EXT:cell denotes cells
T8255 959-963 UBERON_EXT:bone_element_or_tissue denotes bone
T8256 1013-1020 UBERON:0008883 denotes osteoid
T8257 1034-1049 UBERON:0002483 denotes trabecular bone
T8258 1057-1075 UBERON:0002484 denotes bone marrow cavity
T8259 1103-1116 UBERON:0001439 denotes cortical bone
T8260 1120-1125 GO:0007567 denotes birth
T8261 1171-1176 UBERON:0002101 denotes limbs
T8262 1190-1194 PR_EXT:000000164 denotes BMP2
T8263 1199-1203 PR_EXT:000000165 denotes BMP4
T8264 1245-1257 UBERON:0010363 denotes endochondral
T8265 1285-1300 GO:0001944 denotes vascularization
T8266 1311-1315 PR_EXT:000000164 denotes Bmp2
T8267 1320-1324 PR_EXT:000000165 denotes Bmp4
T8268 1329-1333 PR_EXT:000013316 denotes Prx1
T8269 1339-1348 UBERON:0002102 denotes forelimbs
T8270 1354-1365 CL:0000092 denotes osteoclasts
T8271 1370-1379 GO_EXT:biological_recruitment denotes recruited
T8272 1387-1408 UBERON:4000088 denotes mineralized cartilage
T8273 1480-1498 UBERON:0002484 denotes bone marrow cavity
T8274 1527-1531 PR_EXT:000000164 denotes BMP2
T8275 1536-1540 PR_EXT:000000165 denotes BMP4
T8276 1551-1562 UBERON:0002371 denotes bone marrow
T8277 1551-1572 GO:0048539 denotes bone marrow formation
T8278 1577-1592 UBERON:0002483 denotes trabecular bone
T8279 1588-1602 GO_EXT:bone_development_or_ossification denotes bone formation
T8280 1627-1632 GO:0007567 denotes birth
T8281 1651-1655 PR_EXT:000000164 denotes BMP2
T8282 1660-1664 PR_EXT:000000165 denotes BMP4
T8283 1700-1704 PR_EXT:000000164 denotes Bmp2
T8284 1709-1713 PR_EXT:000000165 denotes Bmp4
T8285 1718-1722 PR_EXT:000013316 denotes Prx1
T8286 1728-1733 UBERON:0001474 denotes bones
T8287 1737-1742 GO:0007567 denotes birth
T8288 1770-1777 UBERON:0000922 denotes embryos
T8289 1843-1847 UBERON_EXT:bone_element_or_tissue denotes bone
T8290 1843-1857 GO_EXT:bone_development_or_ossification denotes bone formation
T8291 1876-1880 PR_EXT:000000164 denotes BMP2
T8292 1885-1889 PR_EXT:000000165 denotes BMP4
T8293 1916-1920 UBERON_EXT:bone_element_or_tissue denotes bone
T8294 1935-1939 PR_EXT:000000034 denotes BMPs
T8295 1979-1983 PR_EXT:000000164 denotes Bmp2
T8296 1988-1992 PR_EXT:000000165 denotes Bmp4
T8297 1997-2001 PR_EXT:000013316 denotes Prx1
T8298 2007-2011 NCBITaxon:10088 denotes mice
T8299 2081-2085 NCBITaxon:10088 denotes mice
T8300 2089-2093 UBERON_EXT:bone_element_or_tissue denotes bone
T8301 2139-2164 CL:0000743 denotes hypertrophic chondrocytes
T8302 2198-2209 CL:0000062 denotes osteoblasts
T8303 2232-2245 UBERON:0001439 denotes cortical bone
T8304 2253-2270 UBERON:0004769 denotes diaphyseal region
T8305 2315-2344 UBERON:0010357 denotes secondary ossification center
T8306 2325-2337 GO:0001503 denotes ossification
T8307 2412-2441 UBERON:0010357 denotes secondary ossification center
T8308 2422-2434 GO:0001503 denotes ossification
T8309 2495-2506 UBERON:0002371 denotes bone marrow
T8310 2495-2516 GO:0048539 denotes bone marrow formation
T8311 2551-2566 UBERON:0002483 denotes trabecular bone
T8312 2589-2595 UBERON:0000479 denotes tissue
T8313 2637-2641 UBERON_EXT:bone_element_or_tissue denotes bone
T8314 2637-2651 GO_EXT:bone_development_or_ossification denotes bone formation
T8315 2686-2690 PR_EXT:000000164 denotes BMP2
T8316 2695-2699 PR_EXT:000000165 denotes BMP4
T8317 2720-2725 GO:0007567 denotes birth
T8318 2764-2781 UBERON:0004765 denotes skeletal elements
T8319 2796-2803 SO_EXT:sequence_altered_entity denotes mutants
T8320 2848-2857 SO_EXT:wild_type_entity_or_quality denotes wild-type
T8321 2858-2863 UBERON:0002101 denotes limbs
T8322 2901-2905 UBERON_EXT:bone_element_or_tissue denotes bone
T8323 2920-2950 UBERON:0008187 denotes site of hypertrophic cartilage
T8324 2967-2985 UBERON:0002484 denotes bone marrow cavity
T8325 2987-3002 UBERON:0002483 denotes trabecular bone
T8326 3007-3020 UBERON:0001439 denotes cortical bone
T8327 3050-3061 CL:0000092 denotes osteoclasts
T8328 3072-3081 GO_EXT:biological_recruitment denotes recruited
T8329 3099-3120 UBERON:4000088 denotes mineralized cartilage
T8330 3153-3159 UBERON:0000479 denotes tissue
T8331 3214-3235 UBERON:4000088 denotes mineralized cartilage
T8332 3243-3260 UBERON:0004769 denotes diaphyseal region
T8333 3288-3292 UBERON:0000464 denotes void
T8334 3299-3303 UBERON_EXT:bone_element_or_tissue denotes bone
T8335 3299-3313 GO_EXT:bone_development_or_ossification denotes bone formation
T8336 3381-3385 UBERON:0000464 denotes void
T8337 3416-3423 UBERON:0000479 denotes tissues
T8338 3441-3447 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T8339 3462-3463 UBERON_EXT:muscle_structure_or_tissue denotes m
T8340 3498-3516 GO:0045453 denotes resorption of bone
T8341 3512-3516 UBERON_EXT:bone_element_or_tissue denotes bone
T8342 3568-3573 UBERON:0000981 denotes femur
T8343 3577-3583 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8344 3584-3591 NCBITaxon:33208 denotes animals
T8345 3616-3620 UBERON_EXT:bone_element_or_tissue denotes bone
T8346 3684-3694 CL:0000062 denotes osteoblast
T8347 3695-3710 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T8348 3718-3722 PR_EXT:000000164 denotes Bmp2
T8349 3727-3731 PR_EXT:000000165 denotes Bmp4
T8350 3736-3740 PR_EXT:000013316 denotes Prx1
T8351 3746-3750 NCBITaxon:10088 denotes mice
T8352 3783-3787 UBERON:0002101 denotes limb
R5241 T8248 T8247 _lexicallyChainedTo growth plate,hypertrophic zone of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T8089 62-87 CL:0000743 denotes hypertrophic chondrocytes
T8090 108-121 UBERON:0002222 denotes perichondrium
T8091 187-199 GO:0001503 denotes osteogenesis
T8092 228-232 PR:000000164 denotes BMP2
T8093 234-238 PR:000000165 denotes BMP4
T8094 249-254 UBERON:0002101 denotes limbs
T8095 427-431 PR:000000164 denotes BMP2
T8096 436-440 PR:000000165 denotes BMP4
T8097 524-531 UBERON:0000976 denotes humerus
T8098 571-577 GO:0031012 denotes matrix
T8099 578-585 GO:0010467 denotes express
T8100 590-600 CL:0000062 denotes osteoblast
T8101 608-613 PR:000003263 denotes Col I
T8102 658-679 UBERON:4000088 denotes mineralized cartilage
T8103 703-723 _FRAGMENT denotes hypertrophic zone of
T8104 728-740 UBERON:0006772 denotes growth plate
T8105 771-782 CL:0000092 denotes osteoclasts
T8106 861-879 UBERON:0002484 denotes bone marrow cavity
T8107 932-953 CL:0007010 denotes Osteoprogenitor cells
T8108 1013-1020 UBERON:0008883 denotes osteoid
T8109 1034-1049 UBERON:0002483 denotes trabecular bone
T8110 1057-1075 UBERON:0002484 denotes bone marrow cavity
T8111 1103-1116 UBERON:0001439 denotes cortical bone
T8112 1120-1125 GO:0007567 denotes birth
T8113 1171-1176 UBERON:0002101 denotes limbs
T8114 1190-1194 PR:000000164 denotes BMP2
T8115 1199-1203 PR:000000165 denotes BMP4
T8116 1245-1257 UBERON:0010363 denotes endochondral
T8117 1285-1300 GO:0001944 denotes vascularization
T8118 1311-1315 PR:000000164 denotes Bmp2
T8119 1320-1324 PR:000000165 denotes Bmp4
T8120 1329-1333 PR:000013316 denotes Prx1
T8121 1339-1348 UBERON:0002102 denotes forelimbs
T8122 1354-1365 CL:0000092 denotes osteoclasts
T8123 1387-1408 UBERON:4000088 denotes mineralized cartilage
T8124 1480-1498 UBERON:0002484 denotes bone marrow cavity
T8125 1527-1531 PR:000000164 denotes BMP2
T8126 1536-1540 PR:000000165 denotes BMP4
T8127 1551-1562 UBERON:0002371 denotes bone marrow
T8128 1551-1572 GO:0048539 denotes bone marrow formation
T8129 1577-1592 UBERON:0002483 denotes trabecular bone
T8130 1627-1632 GO:0007567 denotes birth
T8131 1651-1655 PR:000000164 denotes BMP2
T8132 1660-1664 PR:000000165 denotes BMP4
T8133 1700-1704 PR:000000164 denotes Bmp2
T8134 1709-1713 PR:000000165 denotes Bmp4
T8135 1718-1722 PR:000013316 denotes Prx1
T8136 1728-1733 UBERON:0001474 denotes bones
T8137 1737-1742 GO:0007567 denotes birth
T8138 1770-1777 UBERON:0000922 denotes embryos
T8139 1876-1880 PR:000000164 denotes BMP2
T8140 1885-1889 PR:000000165 denotes BMP4
T8141 1935-1939 PR:000000034 denotes BMPs
T8142 1979-1983 PR:000000164 denotes Bmp2
T8143 1988-1992 PR:000000165 denotes Bmp4
T8144 1997-2001 PR:000013316 denotes Prx1
T8145 2007-2011 NCBITaxon:10088 denotes mice
T8146 2081-2085 NCBITaxon:10088 denotes mice
T8147 2139-2164 CL:0000743 denotes hypertrophic chondrocytes
T8148 2198-2209 CL:0000062 denotes osteoblasts
T8149 2232-2245 UBERON:0001439 denotes cortical bone
T8150 2253-2270 UBERON:0004769 denotes diaphyseal region
T8151 2315-2344 UBERON:0010357 denotes secondary ossification center
T8152 2325-2337 GO:0001503 denotes ossification
T8153 2412-2441 UBERON:0010357 denotes secondary ossification center
T8154 2422-2434 GO:0001503 denotes ossification
T8155 2495-2506 UBERON:0002371 denotes bone marrow
T8156 2495-2516 GO:0048539 denotes bone marrow formation
T8157 2551-2566 UBERON:0002483 denotes trabecular bone
T8158 2589-2595 UBERON:0000479 denotes tissue
T8159 2686-2690 PR:000000164 denotes BMP2
T8160 2695-2699 PR:000000165 denotes BMP4
T8161 2720-2725 GO:0007567 denotes birth
T8162 2764-2781 UBERON:0004765 denotes skeletal elements
T8163 2858-2863 UBERON:0002101 denotes limbs
T8164 2920-2950 UBERON:0008187 denotes site of hypertrophic cartilage
T8165 2967-2985 UBERON:0002484 denotes bone marrow cavity
T8166 2987-3002 UBERON:0002483 denotes trabecular bone
T8167 3007-3020 UBERON:0001439 denotes cortical bone
T8168 3050-3061 CL:0000092 denotes osteoclasts
T8169 3099-3120 UBERON:4000088 denotes mineralized cartilage
T8170 3153-3159 UBERON:0000479 denotes tissue
T8171 3214-3235 UBERON:4000088 denotes mineralized cartilage
T8172 3243-3260 UBERON:0004769 denotes diaphyseal region
T8173 3288-3292 UBERON:0000464 denotes void
T8174 3381-3385 UBERON:0000464 denotes void
T8175 3416-3423 UBERON:0000479 denotes tissues
T8176 3498-3516 GO:0045453 denotes resorption of bone
T8177 3568-3573 UBERON:0000981 denotes femur
T8178 3584-3591 NCBITaxon:33208 denotes animals
T8179 3684-3694 CL:0000062 denotes osteoblast
T8180 3718-3722 PR:000000164 denotes Bmp2
T8181 3727-3731 PR:000000165 denotes Bmp4
T8182 3736-3740 PR:000013316 denotes Prx1
T8183 3746-3750 NCBITaxon:10088 denotes mice
T8184 3783-3787 UBERON:0002101 denotes limb
R5239 T8104 T8103 _lexicallyChainedTo growth plate,hypertrophic zone of