PMC:1713256 / 33453-41906 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T8396	0-12	NN	denotes	Osteogenesis
T8397	16-25	VBN	denotes	Initiated
T8398	13-15	VBZ	denotes	Is
T8399	26-34	RB	denotes	Normally
T8400	35-37	IN	denotes	in
T8401	38-42	NN	denotes	BMP2
T8402	44-48	NN	denotes	BMP4
T8403	42-44	,	denotes	,
T8404	49-58	JJ	denotes	Deficient
T8405	48-49	HYPH	denotes	–
T8406	64-68	NNS	denotes	Buds
T8407	59-63	NN	denotes	Limb
T8408	68-231	sentence	denotes	Bone formation first occurs at the interface between the late hypertrophic chondrocytes and the surrounding perichondrium, a region identified as the bone collar.
T8409	69-73	NN	denotes	Bone
T8410	74-83	NN	denotes	formation
T8411	90-96	VBZ	denotes	occurs
T8412	84-89	RB	denotes	first
T8413	97-99	IN	denotes	at
T8414	100-103	DT	denotes	the
T8415	104-113	NN	denotes	interface
T8416	114-121	IN	denotes	between
T8417	122-125	DT	denotes	the
T8418	144-156	NNS	denotes	chondrocytes
T8419	126-130	JJ	denotes	late
T8420	131-143	JJ	denotes	hypertrophic
T8421	157-160	CC	denotes	and
T8422	161-164	DT	denotes	the
T8423	177-190	NN	denotes	perichondrium
T8424	165-176	VBG	denotes	surrounding
T8425	190-192	,	denotes	,
T8426	192-193	DT	denotes	a
T8427	194-200	NN	denotes	region
T8428	201-211	VBN	denotes	identified
T8429	212-214	IN	denotes	as
T8430	215-218	DT	denotes	the
T8431	224-230	NN	denotes	collar
T8432	219-223	NN	denotes	bone
T8433	230-231	.	denotes	.
T8434	231-405	sentence	denotes	We examined whether the osteogenesis program is initiated in the BMP2, BMP4–deficient limbs using several histological and molecular criteria, as described below (Figure 5).
T8435	232-234	PRP	denotes	We
T8436	235-243	VBD	denotes	examined
T8437	244-251	IN	denotes	whether
T8438	280-289	VBN	denotes	initiated
T8439	252-255	DT	denotes	the
T8440	269-276	NN	denotes	program
T8441	256-268	NN	denotes	osteogenesis
T8442	277-279	VBZ	denotes	is
T8443	290-292	IN	denotes	in
T8444	293-296	DT	denotes	the
T8445	318-323	NNS	denotes	limbs
T8446	297-301	NN	denotes	BMP2
T8447	303-307	NN	denotes	BMP4
T8448	301-303	,	denotes	,
T8449	308-317	JJ	denotes	deficient
T8450	307-308	HYPH	denotes	–
T8451	324-329	VBG	denotes	using
T8452	330-337	JJ	denotes	several
T8453	365-373	NNS	denotes	criteria
T8454	338-350	JJ	denotes	histological
T8455	351-354	CC	denotes	and
T8456	355-364	JJ	denotes	molecular
T8457	373-375	,	denotes	,
T8458	375-377	IN	denotes	as
T8459	378-387	VBN	denotes	described
T8460	388-393	RB	denotes	below
T8461	394-395	-LRB-	denotes	(
T8462	395-401	NN	denotes	Figure
T8463	402-403	CD	denotes	5
T8464	403-404	-RRB-	denotes	)
T8465	404-405	.	denotes	.
T8466	405-539	sentence	denotes	Adjacent to the hypertrophic cells, a bone collar is laid down normally in the absence of BMP2 and BMP4 (Figure 5A and 5B, red star).
T8467	406-414	JJ	denotes	Adjacent
T8468	459-463	VBN	denotes	laid
T8469	415-417	IN	denotes	to
T8470	418-421	DT	denotes	the
T8471	435-440	NNS	denotes	cells
T8472	422-434	JJ	denotes	hypertrophic
T8473	440-442	,	denotes	,
T8474	442-443	DT	denotes	a
T8475	449-455	NN	denotes	collar
T8476	444-448	NN	denotes	bone
T8477	456-458	VBZ	denotes	is
T8478	464-468	RP	denotes	down
T8479	469-477	RB	denotes	normally
T8480	478-480	IN	denotes	in
T8481	481-484	DT	denotes	the
T8482	485-492	NN	denotes	absence
T8483	493-495	IN	denotes	of
T8484	496-500	NN	denotes	BMP2
T8485	501-504	CC	denotes	and
T8486	505-509	NN	denotes	BMP4
T8487	510-511	-LRB-	denotes	(
T8488	533-537	NN	denotes	star
T8489	511-517	NN	denotes	Figure
T8490	518-520	NN	denotes	5A
T8491	521-524	CC	denotes	and
T8492	525-527	NN	denotes	5B
T8493	527-529	,	denotes	,
T8494	529-532	JJ	denotes	red
T8495	537-538	-RRB-	denotes	)
T8496	538-539	.	denotes	.
T8497	539-712	sentence	denotes	As can be seen in sagittal sections through an E15.5 humerus, the cells embedded in the mineralized matrix express the osteoblast marker Col I as normal (Figure 5C and 5D).
T8498	540-542	IN	denotes	As
T8499	550-554	VBN	denotes	seen
T8500	543-546	MD	denotes	can
T8501	547-549	VB	denotes	be
T8502	647-654	VBP	denotes	express
T8503	555-557	IN	denotes	in
T8504	558-566	JJ	denotes	sagittal
T8505	567-575	NNS	denotes	sections
T8506	576-583	IN	denotes	through
T8507	584-586	DT	denotes	an
T8508	593-600	NN	denotes	humerus
T8509	587-592	NN	denotes	E15.5
T8510	600-602	,	denotes	,
T8511	602-605	DT	denotes	the
T8512	606-611	NNS	denotes	cells
T8513	612-620	VBN	denotes	embedded
T8514	621-623	IN	denotes	in
T8515	624-627	DT	denotes	the
T8516	640-646	NN	denotes	matrix
T8517	628-639	VBN	denotes	mineralized
T8518	655-658	DT	denotes	the
T8519	670-676	NN	denotes	marker
T8520	659-669	NN	denotes	osteoblast
T8521	677-680	NN	denotes	Col
T8522	681-682	CD	denotes	I
T8523	683-685	IN	denotes	as
T8524	686-692	JJ	denotes	normal
T8525	693-694	-LRB-	denotes	(
T8526	701-703	NN	denotes	5C
T8527	694-700	NN	denotes	Figure
T8528	704-707	CC	denotes	and
T8529	708-710	NN	denotes	5D
T8530	710-711	-RRB-	denotes	)
T8531	711-712	.	denotes	.
T8532	712-1000	sentence	denotes	By E17.5, the mineralized cartilage that makes up the late hypertrophic zone of the growth plate normally undergoes removal by osteoclasts (Figure 5G, brown-stained cells, red arrows), resulting in the formation of a bone marrow cavity (red arrow in Figure 5E and 5I, see also Figure 6).
T8533	713-715	IN	denotes	By
T8534	819-828	VBZ	denotes	undergoes
T8535	716-721	NN	denotes	E17.5
T8536	721-723	,	denotes	,
T8537	723-726	DT	denotes	the
T8538	739-748	NN	denotes	cartilage
T8539	727-738	JJ	denotes	mineralized
T8540	749-753	WDT	denotes	that
T8541	754-759	VBZ	denotes	makes
T8542	760-762	RP	denotes	up
T8543	763-766	DT	denotes	the
T8544	785-789	NN	denotes	zone
T8545	767-771	JJ	denotes	late
T8546	772-784	JJ	denotes	hypertrophic
T8547	790-792	IN	denotes	of
T8548	793-796	DT	denotes	the
T8549	804-809	NN	denotes	plate
T8550	797-803	NN	denotes	growth
T8551	810-818	RB	denotes	normally
T8552	829-836	NN	denotes	removal
T8553	837-839	IN	denotes	by
T8554	840-851	NNS	denotes	osteoclasts
T8555	852-853	-LRB-	denotes	(
T8556	889-895	NNS	denotes	arrows
T8557	853-859	NN	denotes	Figure
T8558	860-862	NN	denotes	5G
T8559	862-864	,	denotes	,
T8560	864-869	JJ	denotes	brown
T8561	870-877	VBN	denotes	stained
T8562	869-870	HYPH	denotes	-
T8563	878-883	NNS	denotes	cells
T8564	883-885	,	denotes	,
T8565	885-888	JJ	denotes	red
T8566	895-896	-RRB-	denotes	)
T8567	896-898	,	denotes	,
T8568	898-907	VBG	denotes	resulting
T8569	908-910	IN	denotes	in
T8570	911-914	DT	denotes	the
T8571	915-924	NN	denotes	formation
T8572	925-927	IN	denotes	of
T8573	928-929	DT	denotes	a
T8574	942-948	NN	denotes	cavity
T8575	930-934	NN	denotes	bone
T8576	935-941	NN	denotes	marrow
T8577	949-950	-LRB-	denotes	(
T8578	954-959	NN	denotes	arrow
T8579	950-953	JJ	denotes	red
T8580	960-962	IN	denotes	in
T8581	963-969	NN	denotes	Figure
T8582	970-972	NN	denotes	5E
T8583	973-976	CC	denotes	and
T8584	977-979	NN	denotes	5I
T8585	979-981	,	denotes	,
T8586	981-984	VB	denotes	see
T8587	985-989	RB	denotes	also
T8588	990-996	NN	denotes	Figure
T8589	997-998	CD	denotes	6
T8590	998-999	-RRB-	denotes	)
T8591	999-1000	.	denotes	.
T8592	1000-1217	sentence	denotes	Osteoprogenitor cells from bone collar region now populate this site and deposit osteoid, forming the trabecular bone in the bone marrow cavity (Figure 6E, red arrow) and cortical bone at birth (Figure 5I, asterisk).
T8593	1001-1016	NN	denotes	Osteoprogenitor
T8594	1017-1022	NNS	denotes	cells
T8595	1051-1059	VBP	denotes	populate
T8596	1023-1027	IN	denotes	from
T8597	1028-1032	NN	denotes	bone
T8598	1040-1046	NN	denotes	region
T8599	1033-1039	NN	denotes	collar
T8600	1047-1050	RB	denotes	now
T8601	1060-1064	DT	denotes	this
T8602	1065-1069	NN	denotes	site
T8603	1070-1073	CC	denotes	and
T8604	1074-1081	VBP	denotes	deposit
T8605	1082-1089	NN	denotes	osteoid
T8606	1089-1091	,	denotes	,
T8607	1091-1098	VBG	denotes	forming
T8608	1099-1102	DT	denotes	the
T8609	1114-1118	NN	denotes	bone
T8610	1103-1113	JJ	denotes	trabecular
T8611	1119-1121	IN	denotes	in
T8612	1122-1125	DT	denotes	the
T8613	1138-1144	NN	denotes	cavity
T8614	1126-1130	NN	denotes	bone
T8615	1131-1137	NN	denotes	marrow
T8616	1145-1146	-LRB-	denotes	(
T8617	1161-1166	NN	denotes	arrow
T8618	1146-1152	NN	denotes	Figure
T8619	1153-1155	NN	denotes	6E
T8620	1155-1157	,	denotes	,
T8621	1157-1160	JJ	denotes	red
T8622	1166-1167	-RRB-	denotes	)
T8623	1168-1171	CC	denotes	and
T8624	1172-1180	JJ	denotes	cortical
T8625	1181-1185	NN	denotes	bone
T8626	1186-1188	IN	denotes	at
T8627	1189-1194	NN	denotes	birth
T8628	1195-1196	-LRB-	denotes	(
T8629	1207-1215	NN	denotes	asterisk
T8630	1196-1202	NN	denotes	Figure
T8631	1203-1205	NN	denotes	5I
T8632	1205-1207	,	denotes	,
T8633	1215-1216	-RRB-	denotes	)
T8634	1216-1217	.	denotes	.
T8635	1217-1347	sentence	denotes	In contrast, in E17.5 limbs deficient in BMP2 and BMP4, there is an overall delay in the normal endochondral process (Figure 5F).
T8636	1218-1220	IN	denotes	In
T8637	1280-1282	VBZ	denotes	is
T8638	1221-1229	NN	denotes	contrast
T8639	1229-1231	,	denotes	,
T8640	1231-1233	IN	denotes	in
T8641	1234-1239	NN	denotes	E17.5
T8642	1240-1245	NNS	denotes	limbs
T8643	1246-1255	JJ	denotes	deficient
T8644	1256-1258	IN	denotes	in
T8645	1259-1263	NN	denotes	BMP2
T8646	1264-1267	CC	denotes	and
T8647	1268-1272	NN	denotes	BMP4
T8648	1272-1274	,	denotes	,
T8649	1274-1279	EX	denotes	there
T8650	1283-1285	DT	denotes	an
T8651	1294-1299	NN	denotes	delay
T8652	1286-1293	JJ	denotes	overall
T8653	1300-1302	IN	denotes	in
T8654	1303-1306	DT	denotes	the
T8655	1327-1334	NN	denotes	process
T8656	1307-1313	JJ	denotes	normal
T8657	1314-1326	JJ	denotes	endochondral
T8658	1335-1336	-LRB-	denotes	(
T8659	1343-1345	NN	denotes	5F
T8660	1336-1342	NN	denotes	Figure
T8661	1345-1346	-RRB-	denotes	)
T8662	1346-1347	.	denotes	.
T8663	1347-1610	sentence	denotes	While vascularization occurs in Bmp2C/C; Bmp4C/C; Prx1::cre forelimbs, few osteoclasts are recruited to the mineralized cartilage (compare Figure 5G and Figure 5H, red arrows), resulting in a delay in bone marrow cavity formation in the absence of BMP2 and BMP4.
T8664	1348-1353	IN	denotes	While
T8665	1370-1376	VBZ	denotes	occurs
T8666	1354-1369	NN	denotes	vascularization
T8667	1439-1448	VBN	denotes	recruited
T8668	1377-1379	IN	denotes	in
T8669	1380-1385	NN	denotes	Bmp2C
T8670	1386-1387	NN	denotes	C
T8671	1385-1386	HYPH	denotes	/
T8672	1408-1417	NNS	denotes	forelimbs
T8673	1387-1388	:	denotes	;
T8674	1389-1394	NN	denotes	Bmp4C
T8675	1395-1396	NN	denotes	C
T8676	1394-1395	HYPH	denotes	/
T8677	1396-1397	:	denotes	;
T8678	1398-1402	NN	denotes	Prx1
T8679	1404-1407	NN	denotes	cre
T8680	1402-1403	HYPH	denotes	:
T8681	1403-1404	HYPH	denotes	:
T8682	1417-1419	,	denotes	,
T8683	1419-1422	JJ	denotes	few
T8684	1423-1434	NNS	denotes	osteoclasts
T8685	1435-1438	VBP	denotes	are
T8686	1449-1451	IN	denotes	to
T8687	1452-1455	DT	denotes	the
T8688	1468-1477	NN	denotes	cartilage
T8689	1456-1467	VBN	denotes	mineralized
T8690	1478-1479	-LRB-	denotes	(
T8691	1516-1522	NNS	denotes	arrows
T8692	1479-1486	VB	denotes	compare
T8693	1487-1493	NN	denotes	Figure
T8694	1494-1496	NN	denotes	5G
T8695	1497-1500	CC	denotes	and
T8696	1501-1507	NN	denotes	Figure
T8697	1508-1510	NN	denotes	5H
T8698	1510-1512	,	denotes	,
T8699	1512-1515	JJ	denotes	red
T8700	1522-1523	-RRB-	denotes	)
T8701	1523-1525	,	denotes	,
T8702	1525-1534	VBG	denotes	resulting
T8703	1535-1537	IN	denotes	in
T8704	1538-1539	DT	denotes	a
T8705	1540-1545	NN	denotes	delay
T8706	1546-1548	IN	denotes	in
T8707	1549-1553	NN	denotes	bone
T8708	1554-1560	NN	denotes	marrow
T8709	1568-1577	NN	denotes	formation
T8710	1561-1567	NN	denotes	cavity
T8711	1578-1580	IN	denotes	in
T8712	1581-1584	DT	denotes	the
T8713	1585-1592	NN	denotes	absence
T8714	1593-1595	IN	denotes	of
T8715	1596-1600	NN	denotes	BMP2
T8716	1601-1604	CC	denotes	and
T8717	1605-1609	NN	denotes	BMP4
T8718	1609-1610	.	denotes	.
T8719	1610-1868	sentence	denotes	In fact, bone marrow formation and trabecular bone formation have not yet started at birth in the absence of BMP2 and BMP4 (Figure 5J), and the morphology of Bmp2C/C; Bmp4C/C; Prx1::cre bones at birth is most similar to control embryos at E17.5 (Figure 5E).
T8720	1611-1613	IN	denotes	In
T8721	1685-1692	VBN	denotes	started
T8722	1614-1618	NN	denotes	fact
T8723	1618-1620	,	denotes	,
T8724	1620-1624	NN	denotes	bone
T8725	1625-1631	NN	denotes	marrow
T8726	1632-1641	NN	denotes	formation
T8727	1642-1645	CC	denotes	and
T8728	1646-1656	JJ	denotes	trabecular
T8729	1662-1671	NN	denotes	formation
T8730	1657-1661	NN	denotes	bone
T8731	1672-1676	VBP	denotes	have
T8732	1677-1680	RB	denotes	not
T8733	1681-1684	RB	denotes	yet
T8734	1693-1695	IN	denotes	at
T8735	1696-1701	NN	denotes	birth
T8736	1702-1704	IN	denotes	in
T8737	1705-1708	DT	denotes	the
T8738	1709-1716	NN	denotes	absence
T8739	1717-1719	IN	denotes	of
T8740	1720-1724	NN	denotes	BMP2
T8741	1725-1728	CC	denotes	and
T8742	1729-1733	NN	denotes	BMP4
T8743	1734-1735	-LRB-	denotes	(
T8744	1742-1744	NN	denotes	5J
T8745	1735-1741	NN	denotes	Figure
T8746	1744-1745	-RRB-	denotes	)
T8747	1745-1747	,	denotes	,
T8748	1747-1750	CC	denotes	and
T8749	1751-1754	DT	denotes	the
T8750	1755-1765	NN	denotes	morphology
T8751	1812-1814	VBZ	denotes	is
T8752	1766-1768	IN	denotes	of
T8753	1769-1774	NN	denotes	Bmp2C
T8754	1775-1776	NN	denotes	C
T8755	1774-1775	HYPH	denotes	/
T8756	1797-1802	NNS	denotes	bones
T8757	1776-1777	:	denotes	;
T8758	1778-1783	NN	denotes	Bmp4C
T8759	1784-1785	NN	denotes	C
T8760	1783-1784	HYPH	denotes	/
T8761	1785-1786	:	denotes	;
T8762	1787-1791	NN	denotes	Prx1
T8763	1793-1796	NN	denotes	cre
T8764	1791-1792	HYPH	denotes	:
T8765	1792-1793	HYPH	denotes	:
T8766	1803-1805	IN	denotes	at
T8767	1806-1811	NN	denotes	birth
T8768	1815-1819	RBS	denotes	most
T8769	1820-1827	JJ	denotes	similar
T8770	1828-1830	IN	denotes	to
T8771	1831-1838	NN	denotes	control
T8772	1839-1846	NNS	denotes	embryos
T8773	1847-1849	IN	denotes	at
T8774	1850-1855	NN	denotes	E17.5
T8775	1856-1857	-LRB-	denotes	(
T8776	1864-1866	NN	denotes	5E
T8777	1857-1863	NN	denotes	Figure
T8778	1866-1867	-RRB-	denotes	)
T8779	1867-1868	.	denotes	.
T8780	1868-2100	sentence	denotes	To differentiate between a simple delay in bone formation in the absence of BMP2 and BMP4 and the inability to form bone without these BMPs, we performed histological analyses in Bmp2C/C; Bmp4C/C; Prx1::cre mice up to 3 wks of age.
T8781	1869-1871	TO	denotes	To
T8782	1872-1885	VB	denotes	differentiate
T8783	2013-2022	VBD	denotes	performed
T8784	1886-1893	IN	denotes	between
T8785	1894-1895	DT	denotes	a
T8786	1903-1908	NN	denotes	delay
T8787	1896-1902	JJ	denotes	simple
T8788	1909-1911	IN	denotes	in
T8789	1912-1916	NN	denotes	bone
T8790	1917-1926	NN	denotes	formation
T8791	1927-1929	IN	denotes	in
T8792	1930-1933	DT	denotes	the
T8793	1934-1941	NN	denotes	absence
T8794	1942-1944	IN	denotes	of
T8795	1945-1949	NN	denotes	BMP2
T8796	1950-1953	CC	denotes	and
T8797	1954-1958	NN	denotes	BMP4
T8798	1959-1962	CC	denotes	and
T8799	1963-1966	DT	denotes	the
T8800	1967-1976	NN	denotes	inability
T8801	1977-1979	TO	denotes	to
T8802	1980-1984	VB	denotes	form
T8803	1985-1989	NN	denotes	bone
T8804	1990-1997	IN	denotes	without
T8805	1998-2003	DT	denotes	these
T8806	2004-2008	NNS	denotes	BMPs
T8807	2008-2010	,	denotes	,
T8808	2010-2012	PRP	denotes	we
T8809	2023-2035	JJ	denotes	histological
T8810	2036-2044	NNS	denotes	analyses
T8811	2045-2047	IN	denotes	in
T8812	2048-2053	NN	denotes	Bmp2C
T8813	2054-2055	NN	denotes	C
T8814	2053-2054	HYPH	denotes	/
T8815	2076-2080	NNS	denotes	mice
T8816	2055-2056	:	denotes	;
T8817	2057-2062	NN	denotes	Bmp4C
T8818	2063-2064	NN	denotes	C
T8819	2062-2063	HYPH	denotes	/
T8820	2064-2065	:	denotes	;
T8821	2066-2070	NN	denotes	Prx1
T8822	2072-2075	NN	denotes	cre
T8823	2070-2071	HYPH	denotes	:
T8824	2071-2072	HYPH	denotes	:
T8825	2081-2083	RB	denotes	up
T8826	2087-2088	CD	denotes	3
T8827	2084-2086	IN	denotes	to
T8828	2089-2092	NNS	denotes	wks
T8829	2093-2095	IN	denotes	of
T8830	2096-2099	NN	denotes	age
T8831	2099-2100	.	denotes	.
T8832	2100-2261	sentence	denotes	As shown in Figure 6A through 6E, in the control mice, a bone collar is found adjacent to the zone of late hypertrophic chondrocytes at 1 wk (Figure 6A and 6B).
T8833	2101-2103	IN	denotes	As
T8834	2104-2109	VBN	denotes	shown
T8835	2173-2178	VBN	denotes	found
T8836	2110-2112	IN	denotes	in
T8837	2113-2119	NN	denotes	Figure
T8838	2120-2122	NN	denotes	6A
T8839	2123-2130	IN	denotes	through
T8840	2131-2133	NN	denotes	6E
T8841	2133-2135	,	denotes	,
T8842	2135-2137	IN	denotes	in
T8843	2138-2141	DT	denotes	the
T8844	2150-2154	NNS	denotes	mice
T8845	2142-2149	NN	denotes	control
T8846	2154-2156	,	denotes	,
T8847	2156-2157	DT	denotes	a
T8848	2163-2169	NN	denotes	collar
T8849	2158-2162	NN	denotes	bone
T8850	2170-2172	VBZ	denotes	is
T8851	2179-2187	JJ	denotes	adjacent
T8852	2188-2190	IN	denotes	to
T8853	2191-2194	DT	denotes	the
T8854	2195-2199	NN	denotes	zone
T8855	2200-2202	IN	denotes	of
T8856	2203-2207	JJ	denotes	late
T8857	2221-2233	NNS	denotes	chondrocytes
T8858	2208-2220	JJ	denotes	hypertrophic
T8859	2234-2236	IN	denotes	at
T8860	2237-2238	CD	denotes	1
T8861	2239-2241	NN	denotes	wk
T8862	2242-2243	-LRB-	denotes	(
T8863	2250-2252	NN	denotes	6A
T8864	2243-2249	NN	denotes	Figure
T8865	2253-2256	CC	denotes	and
T8866	2257-2259	NN	denotes	6B
T8867	2259-2260	-RRB-	denotes	)
T8868	2260-2261	.	denotes	.
T8869	2261-2446	sentence	denotes	Many osteoblasts line the newly formed cortical bone in the diaphyseal region (Figure 6C, blue arrow), and formation of a secondary ossification center has begun (Figure 6A, red star).
T8870	2262-2266	JJ	denotes	Many
T8871	2267-2278	NNS	denotes	osteoblasts
T8872	2279-2283	VBP	denotes	line
T8873	2284-2287	DT	denotes	the
T8874	2310-2314	NN	denotes	bone
T8875	2288-2293	RB	denotes	newly
T8876	2294-2300	VBN	denotes	formed
T8877	2301-2309	JJ	denotes	cortical
T8878	2315-2317	IN	denotes	in
T8879	2318-2321	DT	denotes	the
T8880	2333-2339	NN	denotes	region
T8881	2322-2332	JJ	denotes	diaphyseal
T8882	2340-2341	-LRB-	denotes	(
T8883	2357-2362	NN	denotes	arrow
T8884	2341-2347	NN	denotes	Figure
T8885	2348-2350	NN	denotes	6C
T8886	2350-2352	,	denotes	,
T8887	2352-2356	JJ	denotes	blue
T8888	2362-2363	-RRB-	denotes	)
T8889	2363-2365	,	denotes	,
T8890	2365-2368	CC	denotes	and
T8891	2369-2378	NN	denotes	formation
T8892	2418-2423	VBN	denotes	begun
T8893	2379-2381	IN	denotes	of
T8894	2382-2383	DT	denotes	a
T8895	2407-2413	NN	denotes	center
T8896	2384-2393	JJ	denotes	secondary
T8897	2394-2406	NN	denotes	ossification
T8898	2414-2417	VBZ	denotes	has
T8899	2424-2425	-LRB-	denotes	(
T8900	2440-2444	NN	denotes	star
T8901	2425-2431	NN	denotes	Figure
T8902	2432-2434	NN	denotes	6A
T8903	2434-2436	,	denotes	,
T8904	2436-2439	JJ	denotes	red
T8905	2444-2445	-RRB-	denotes	)
T8906	2445-2446	.	denotes	.
T8907	2446-2686	sentence	denotes	At 3 wks of age, formation of the secondary ossification center is complete (Figure 6D, red star), along with robust bone marrow formation (Figure 6D, bm) and deposition of trabecular bone (Figure 6E, pale blue tissue marked by red arrow).
T8908	2447-2449	IN	denotes	At
T8909	2511-2513	VBZ	denotes	is
T8910	2450-2451	CD	denotes	3
T8911	2452-2455	NNS	denotes	wks
T8912	2456-2458	IN	denotes	of
T8913	2459-2462	NN	denotes	age
T8914	2462-2464	,	denotes	,
T8915	2464-2473	NN	denotes	formation
T8916	2474-2476	IN	denotes	of
T8917	2477-2480	DT	denotes	the
T8918	2504-2510	NN	denotes	center
T8919	2481-2490	JJ	denotes	secondary
T8920	2491-2503	NN	denotes	ossification
T8921	2514-2522	JJ	denotes	complete
T8922	2523-2524	-LRB-	denotes	(
T8923	2539-2543	NN	denotes	star
T8924	2524-2530	NN	denotes	Figure
T8925	2531-2533	NN	denotes	6D
T8926	2533-2535	,	denotes	,
T8927	2535-2538	JJ	denotes	red
T8928	2543-2544	-RRB-	denotes	)
T8929	2544-2546	,	denotes	,
T8930	2546-2551	IN	denotes	along
T8931	2552-2556	IN	denotes	with
T8932	2557-2563	JJ	denotes	robust
T8933	2576-2585	NN	denotes	formation
T8934	2564-2568	NN	denotes	bone
T8935	2569-2575	NN	denotes	marrow
T8936	2586-2587	-LRB-	denotes	(
T8937	2598-2600	NN	denotes	bm
T8938	2587-2593	NN	denotes	Figure
T8939	2594-2596	NN	denotes	6D
T8940	2596-2598	,	denotes	,
T8941	2600-2601	-RRB-	denotes	)
T8942	2602-2605	CC	denotes	and
T8943	2606-2616	NN	denotes	deposition
T8944	2617-2619	IN	denotes	of
T8945	2620-2630	JJ	denotes	trabecular
T8946	2631-2635	NN	denotes	bone
T8947	2636-2637	-LRB-	denotes	(
T8948	2658-2664	NN	denotes	tissue
T8949	2637-2643	NN	denotes	Figure
T8950	2644-2646	NN	denotes	6E
T8951	2646-2648	,	denotes	,
T8952	2648-2652	JJ	denotes	pale
T8953	2653-2657	JJ	denotes	blue
T8954	2665-2671	VBN	denotes	marked
T8955	2672-2674	IN	denotes	by
T8956	2675-2678	JJ	denotes	red
T8957	2679-2684	NN	denotes	arrow
T8958	2684-2685	-RRB-	denotes	)
T8959	2685-2686	.	denotes	.
T8960	2686-2810	sentence	denotes	In stark contrast, bone formation is not observed in the absence of BMP2 and BMP4 at 1 or 3 wks after birth (Figure 6F–6J).
T8961	2687-2689	IN	denotes	In
T8962	2728-2736	VBN	denotes	observed
T8963	2690-2695	JJ	denotes	stark
T8964	2696-2704	NN	denotes	contrast
T8965	2704-2706	,	denotes	,
T8966	2706-2710	NN	denotes	bone
T8967	2711-2720	NN	denotes	formation
T8968	2721-2723	VBZ	denotes	is
T8969	2724-2727	RB	denotes	not
T8970	2737-2739	IN	denotes	in
T8971	2740-2743	DT	denotes	the
T8972	2744-2751	NN	denotes	absence
T8973	2752-2754	IN	denotes	of
T8974	2755-2759	NN	denotes	BMP2
T8975	2760-2763	CC	denotes	and
T8976	2764-2768	NN	denotes	BMP4
T8977	2769-2771	IN	denotes	at
T8978	2772-2773	CD	denotes	1
T8979	2779-2782	NNS	denotes	wks
T8980	2774-2776	CC	denotes	or
T8981	2777-2778	CD	denotes	3
T8982	2783-2788	IN	denotes	after
T8983	2789-2794	NN	denotes	birth
T8984	2795-2796	-LRB-	denotes	(
T8985	2803-2805	NN	denotes	6F
T8986	2796-2802	NN	denotes	Figure
T8987	2805-2806	SYM	denotes	–
T8988	2806-2808	NN	denotes	6J
T8989	2808-2809	-RRB-	denotes	)
T8990	2809-2810	.	denotes	.
T8991	2810-3113	sentence	denotes	The appearance of the skeletal elements in the double mutants remains similar to E17.5 structures seen in wild-type limbs (Figure 5E), and although there is a bone collar at the site of hypertrophic cartilage (Figure 6G), no bone marrow cavity, trabecular bone, or cortical bone is present (Figure 6F).
T8992	2811-2814	DT	denotes	The
T8993	2815-2825	NN	denotes	appearance
T8994	2873-2880	VBZ	denotes	remains
T8995	2826-2828	IN	denotes	of
T8996	2829-2832	DT	denotes	the
T8997	2842-2850	NNS	denotes	elements
T8998	2833-2841	JJ	denotes	skeletal
T8999	2851-2853	IN	denotes	in
T9000	2854-2857	DT	denotes	the
T9001	2865-2872	NNS	denotes	mutants
T9002	2858-2864	JJ	denotes	double
T9003	2881-2888	JJ	denotes	similar
T9004	2889-2891	IN	denotes	to
T9005	2892-2897	NN	denotes	E17.5
T9006	2898-2908	NNS	denotes	structures
T9007	2909-2913	VBN	denotes	seen
T9008	2914-2916	IN	denotes	in
T9009	2917-2921	JJ	denotes	wild
T9010	2922-2926	NN	denotes	type
T9011	2921-2922	HYPH	denotes	-
T9012	2927-2932	NNS	denotes	limbs
T9013	2933-2934	-LRB-	denotes	(
T9014	2941-2943	NN	denotes	5E
T9015	2934-2940	NN	denotes	Figure
T9016	2943-2944	-RRB-	denotes	)
T9017	2944-2946	,	denotes	,
T9018	2946-2949	CC	denotes	and
T9019	2950-2958	IN	denotes	although
T9020	2965-2967	VBZ	denotes	is
T9021	2959-2964	EX	denotes	there
T9022	3090-3092	VBZ	denotes	is
T9023	2968-2969	DT	denotes	a
T9024	2975-2981	NN	denotes	collar
T9025	2970-2974	NN	denotes	bone
T9026	2982-2984	IN	denotes	at
T9027	2985-2988	DT	denotes	the
T9028	2989-2993	NN	denotes	site
T9029	2994-2996	IN	denotes	of
T9030	2997-3009	JJ	denotes	hypertrophic
T9031	3010-3019	NN	denotes	cartilage
T9032	3020-3021	-LRB-	denotes	(
T9033	3028-3030	NN	denotes	6G
T9034	3021-3027	NN	denotes	Figure
T9035	3030-3031	-RRB-	denotes	)
T9036	3031-3033	,	denotes	,
T9037	3033-3035	DT	denotes	no
T9038	3048-3054	NN	denotes	cavity
T9039	3036-3040	NN	denotes	bone
T9040	3041-3047	NN	denotes	marrow
T9041	3054-3056	,	denotes	,
T9042	3056-3066	JJ	denotes	trabecular
T9043	3067-3071	NN	denotes	bone
T9044	3071-3073	,	denotes	,
T9045	3073-3075	CC	denotes	or
T9046	3076-3084	JJ	denotes	cortical
T9047	3085-3089	NN	denotes	bone
T9048	3093-3100	JJ	denotes	present
T9049	3101-3102	-LRB-	denotes	(
T9050	3109-3111	NN	denotes	6F
T9051	3102-3108	NN	denotes	Figure
T9052	3111-3112	-RRB-	denotes	)
T9053	3112-3113	.	denotes	.
T9054	3113-3444	sentence	denotes	Many osteoclasts have been recruited to the remaining mineralized cartilage and are actively resorbing this tissue (red asterisks, Figure 6I), so that by 3 wks, all the mineralized cartilage in the diaphyseal region has disappeared, leaving a void where bone formation should have occurred (Figure 6J, also see Figures 6L and S3).
T9055	3114-3118	JJ	denotes	Many
T9056	3119-3130	NNS	denotes	osteoclasts
T9057	3141-3150	VBN	denotes	recruited
T9058	3131-3135	VBP	denotes	have
T9059	3136-3140	VBN	denotes	been
T9060	3151-3153	IN	denotes	to
T9061	3154-3157	DT	denotes	the
T9062	3180-3189	NN	denotes	cartilage
T9063	3158-3167	VBG	denotes	remaining
T9064	3168-3179	VBN	denotes	mineralized
T9065	3190-3193	CC	denotes	and
T9066	3194-3197	VBP	denotes	are
T9067	3207-3216	VBG	denotes	resorbing
T9068	3198-3206	RB	denotes	actively
T9069	3217-3221	DT	denotes	this
T9070	3222-3228	NN	denotes	tissue
T9071	3229-3230	-LRB-	denotes	(
T9072	3252-3254	NN	denotes	6I
T9073	3230-3233	JJ	denotes	red
T9074	3234-3243	NNS	denotes	asterisks
T9075	3243-3245	,	denotes	,
T9076	3245-3251	NN	denotes	Figure
T9077	3254-3255	-RRB-	denotes	)
T9078	3255-3257	,	denotes	,
T9079	3257-3259	IN	denotes	so
T9080	3334-3345	VBN	denotes	disappeared
T9081	3260-3264	IN	denotes	that
T9082	3265-3267	IN	denotes	by
T9083	3268-3269	CD	denotes	3
T9084	3270-3273	NNS	denotes	wks
T9085	3273-3275	,	denotes	,
T9086	3275-3278	PDT	denotes	all
T9087	3295-3304	NN	denotes	cartilage
T9088	3279-3282	DT	denotes	the
T9089	3283-3294	VBN	denotes	mineralized
T9090	3305-3307	IN	denotes	in
T9091	3308-3311	DT	denotes	the
T9092	3323-3329	NN	denotes	region
T9093	3312-3322	JJ	denotes	diaphyseal
T9094	3330-3333	VBZ	denotes	has
T9095	3345-3347	,	denotes	,
T9096	3347-3354	VBG	denotes	leaving
T9097	3355-3356	DT	denotes	a
T9098	3357-3361	NN	denotes	void
T9099	3362-3367	WRB	denotes	where
T9100	3395-3403	VBN	denotes	occurred
T9101	3368-3372	NN	denotes	bone
T9102	3373-3382	NN	denotes	formation
T9103	3383-3389	MD	denotes	should
T9104	3390-3394	VB	denotes	have
T9105	3404-3405	-LRB-	denotes	(
T9106	3412-3414	NN	denotes	6J
T9107	3405-3411	NN	denotes	Figure
T9108	3414-3416	,	denotes	,
T9109	3416-3420	RB	denotes	also
T9110	3421-3424	VBP	denotes	see
T9111	3425-3432	NNS	denotes	Figures
T9112	3433-3435	NN	denotes	6L
T9113	3436-3439	CC	denotes	and
T9114	3440-3442	NN	denotes	S3
T9115	3442-3443	-RRB-	denotes	)
T9116	3443-3444	.	denotes	.
T9117	3444-3562	sentence	denotes	This void is eventually invaded by soft tissues and the adjacent muscle (marked s and m, respectively, in Figure 6J).
T9118	3445-3449	DT	denotes	This
T9119	3450-3454	NN	denotes	void
T9120	3469-3476	VBN	denotes	invaded
T9121	3455-3457	VBZ	denotes	is
T9122	3458-3468	RB	denotes	eventually
T9123	3477-3479	IN	denotes	by
T9124	3480-3484	JJ	denotes	soft
T9125	3485-3492	NNS	denotes	tissues
T9126	3493-3496	CC	denotes	and
T9127	3497-3500	DT	denotes	the
T9128	3510-3516	NN	denotes	muscle
T9129	3501-3509	JJ	denotes	adjacent
T9130	3517-3518	-LRB-	denotes	(
T9131	3518-3524	VBN	denotes	marked
T9132	3525-3526	NN	denotes	s
T9133	3527-3530	CC	denotes	and
T9134	3531-3532	NN	denotes	m
T9135	3532-3534	,	denotes	,
T9136	3534-3546	RB	denotes	respectively
T9137	3546-3548	,	denotes	,
T9138	3548-3550	IN	denotes	in
T9139	3551-3557	NN	denotes	Figure
T9140	3558-3560	NN	denotes	6J
T9141	3560-3561	-RRB-	denotes	)
T9142	3561-3562	.	denotes	.
T9143	3562-3726	sentence	denotes	The resorption of bone at 3 wks of age is clearly visible in the proximal femur of mutant animals where a portion of that bone is missing (Figure 6L, black arrow).
T9144	3563-3566	DT	denotes	The
T9145	3567-3577	NN	denotes	resorption
T9146	3602-3604	VBZ	denotes	is
T9147	3578-3580	IN	denotes	of
T9148	3581-3585	NN	denotes	bone
T9149	3586-3588	IN	denotes	at
T9150	3589-3590	CD	denotes	3
T9151	3591-3594	NNS	denotes	wks
T9152	3595-3597	IN	denotes	of
T9153	3598-3601	NN	denotes	age
T9154	3605-3612	RB	denotes	clearly
T9155	3613-3620	JJ	denotes	visible
T9156	3621-3623	IN	denotes	in
T9157	3624-3627	DT	denotes	the
T9158	3637-3642	NN	denotes	femur
T9159	3628-3636	JJ	denotes	proximal
T9160	3643-3645	IN	denotes	of
T9161	3646-3652	NN	denotes	mutant
T9162	3653-3660	NNS	denotes	animals
T9163	3661-3666	WRB	denotes	where
T9164	3690-3692	VBZ	denotes	is
T9165	3667-3668	DT	denotes	a
T9166	3669-3676	NN	denotes	portion
T9167	3677-3679	IN	denotes	of
T9168	3680-3684	DT	denotes	that
T9169	3685-3689	NN	denotes	bone
T9170	3693-3700	JJ	denotes	missing
T9171	3701-3702	-LRB-	denotes	(
T9172	3719-3724	NN	denotes	arrow
T9173	3702-3708	NN	denotes	Figure
T9174	3709-3711	NN	denotes	6L
T9175	3711-3713	,	denotes	,
T9176	3713-3718	JJ	denotes	black
T9177	3724-3725	-RRB-	denotes	)
T9178	3725-3726	.	denotes	.
T9179	3726-3912	sentence	denotes	The inability to complete osteoblast differentiation in the Bmp2C/C; Bmp4C/C; Prx1::cre mice results in strikingly defective limb morphology at 1 wk of age (compare Figure S3G and S3H).
T9180	3727-3730	DT	denotes	The
T9181	3731-3740	NN	denotes	inability
T9182	3820-3827	VBZ	denotes	results
T9183	3741-3743	TO	denotes	to
T9184	3744-3752	VB	denotes	complete
T9185	3753-3763	NN	denotes	osteoblast
T9186	3764-3779	NN	denotes	differentiation
T9187	3780-3782	IN	denotes	in
T9188	3783-3786	DT	denotes	the
T9189	3815-3819	NNS	denotes	mice
T9190	3787-3792	NN	denotes	Bmp2C
T9191	3793-3794	NN	denotes	C
T9192	3792-3793	HYPH	denotes	/
T9193	3794-3795	:	denotes	;
T9194	3796-3801	NN	denotes	Bmp4C
T9195	3802-3803	NN	denotes	C
T9196	3801-3802	HYPH	denotes	/
T9197	3803-3804	:	denotes	;
T9198	3805-3809	NN	denotes	Prx1
T9199	3811-3814	NN	denotes	cre
T9200	3809-3810	HYPH	denotes	:
T9201	3810-3811	HYPH	denotes	:
T9202	3828-3830	IN	denotes	in
T9203	3831-3841	RB	denotes	strikingly
T9204	3842-3851	JJ	denotes	defective
T9205	3857-3867	NN	denotes	morphology
T9206	3852-3856	NN	denotes	limb
T9207	3868-3870	IN	denotes	at
T9208	3871-3872	CD	denotes	1
T9209	3873-3875	NN	denotes	wk
T9210	3876-3878	IN	denotes	of
T9211	3879-3882	NN	denotes	age
T9212	3883-3884	-LRB-	denotes	(
T9213	3884-3891	VB	denotes	compare
T9214	3892-3898	NN	denotes	Figure
T9215	3899-3902	NN	denotes	S3G
T9216	3903-3906	CC	denotes	and
T9217	3907-3910	NN	denotes	S3H
T9218	3910-3911	-RRB-	denotes	)
T9219	3911-3912	.	denotes	.
T9220	3912-7192	sentence	denotes	Figure 5 In the Absence of BMP2 and BMP4, Osteogenesis Begins During Early Embryonic Development (A–D) Sagittal sections of forelimb from E15.5 embryos. (A and B) Stained with toluidine blue. (A) Distal ulna from wild-type embryo, (B) distal ulna/radius from Bmp2C/C; Bmp4C/C; Prx1::cre embryo. Mineralized cartilage is shown by dark purple and osteoid is shown by light blue (red asterisk). (C and D) Humeri sections were hybridized with digoxigenin labeled riboprobe for ColI. (C) Section of wild-type humerus from E15.5 embryo, (D) from Bmp2C/C; Bmp4C/C; Prx1::cre E15.5 embryo. (E–H) Sagittal sections of zeugopod from E17.5 embryos. (E and F) Stained with toluidine blue while G and H are stained for TRAP (brown stain, red arrow). (E and G) E17.5 proximal radius from wild-type embryo, (F and H) E17.5 proximal ulna/radius from Bmp2C/C; Bmp4C/C; Prx1::cre embryo. Although vascularization occurs in the absence of BMP2 and BMP4, few osteoclasts are observed in the mineralized cartilage in Bmp2C/C; Bmp4C/C; Prx1::cre mice. Please note all the panels other than (G) and (H) are photographed at ×20, while (G) and (H) were photographed at ×40. (I and J) Sections of newborn proximal radius (I) from control animal and newborn proximal ulna/radius (J) from Bmp2C/C; Bmp4C/C; Prx1::cre animal were stained with toluidine blue. Red arrow shows the bone marrow cavity in (E) and (I). Note that bone collar (red *) forms at the right time and place in the absence of BMP2 and BMP4. Also note that since Bmp2C/C; Bmp4C/C; Prx1::cre mice occasionally have only one bone in zeugopod and the elbow joint is occasionally fused, it is difficult to distinguish between the ulna and the radius. Figure 6 Defects in Bone Formation in the Absence of BMP2 and BMP4 Toluidine blue staining of sagittal sections of distal femurs. (A–E) Control femurs at 1 wk (A) and 3 wks (D) of age. Boxed areas in (A) are enlarged in (B) and (C). Boxed area in (D) is enlarged in (E). Blue arrows in (C) point to osteoblast cells lining the surface of cortical bone. Pink arrows in (G) show similar cells to those in (C) in Bmp2C/C; Bmp4C/C; Prx1::cre femurs. Red star in (A) and (D) marks the secondary ossification center. Pale blue–stained tissue in (E), marked by red arrows, is trabecular bone. bm, marks the bone marrow cavity in (D). (F–J) Bmp2C/C; Bmp4C/C; Prx1::cre femurs at 1 wk (F) and 3 wks (J) of age. Boxed areas in (F) are enlarged in (G), (H), and (I). (A), (D), (F), and (J) are shown with the same magnification. Note that there are defects in bone formation but no defect in osteoclast mediated bone resorption. Mineralized tissue in the mid shaft of femur is almost resorbed at 3 wks. (H) Fibroblast-like cells present in the bone shaft of Bmp2C/C; Bmp4C/C; Prx1::cre mouse. Red star in (I) shows the osteoclasts invading the Bmp2C/C; Bmp4C/C; Prx1::cre femurs at 1 wk of age. s and m mark soft tissues and muscle in (J), respectively. (K and L) Three-wk-old wild-type (K) and Bmp2C/C; Bmp4C/C; Prx1::cre (L) hindlimb skeletons stained with Alcian blue and Alizarin red. The black arrow shows the missing part of proximal femur. To determine if any osteoblast differentiation occurs in Bmp2C/C; Bmp4C/C; Prx1::cre forelimbs, we examined osteoblast-related gene expression (Figure 7).
T9221	7038-7040	TO	denotes	To
T9222	7041-7050	VB	denotes	determine
T9223	7137-7145	VBD	denotes	examined
T9224	7051-7053	IN	denotes	if
T9225	7085-7091	VBZ	denotes	occurs
T9226	7054-7057	DT	denotes	any
T9227	7069-7084	NN	denotes	differentiation
T9228	7058-7068	NN	denotes	osteoblast
T9229	7092-7094	IN	denotes	in
T9230	7095-7100	NN	denotes	Bmp2C
T9231	7101-7102	NN	denotes	C
T9232	7100-7101	HYPH	denotes	/
T9233	7123-7132	NNS	denotes	forelimbs
T9234	7102-7103	:	denotes	;
T9235	7104-7109	NN	denotes	Bmp4C
T9236	7110-7111	NN	denotes	C
T9237	7109-7110	HYPH	denotes	/
T9238	7111-7112	:	denotes	;
T9239	7113-7117	NN	denotes	Prx1
T9240	7119-7122	NN	denotes	cre
T9241	7117-7118	HYPH	denotes	:
T9242	7118-7119	HYPH	denotes	:
T9243	7132-7134	,	denotes	,
T9244	7134-7136	PRP	denotes	we
T9245	7146-7156	NN	denotes	osteoblast
T9246	7157-7164	VBN	denotes	related
T9247	7156-7157	HYPH	denotes	-
T9248	7170-7180	NN	denotes	expression
T9249	7165-7169	NN	denotes	gene
T9250	7181-7182	-LRB-	denotes	(
T9251	7182-7188	NN	denotes	Figure
T9252	7189-7190	CD	denotes	7
T9253	7190-7191	-RRB-	denotes	)
T9254	7191-7192	.	denotes	.
T9255	7192-7387	sentence	denotes	In the control mice, osteoblasts lining the surface of trabecular and cortical bone express type I collagen, runx2, and osterix genes at both 1 wk and 3 wks after birth (Figure 7A–7D and 7I–7L).
T9256	7193-7195	IN	denotes	In
T9257	7277-7284	VBP	denotes	express
T9258	7196-7199	DT	denotes	the
T9259	7208-7212	NNS	denotes	mice
T9260	7200-7207	NN	denotes	control
T9261	7212-7214	,	denotes	,
T9262	7214-7225	NNS	denotes	osteoblasts
T9263	7226-7232	VBG	denotes	lining
T9264	7233-7236	DT	denotes	the
T9265	7237-7244	NN	denotes	surface
T9266	7245-7247	IN	denotes	of
T9267	7248-7258	JJ	denotes	trabecular
T9268	7272-7276	NN	denotes	bone
T9269	7259-7262	CC	denotes	and
T9270	7263-7271	JJ	denotes	cortical
T9271	7285-7289	NN	denotes	type
T9272	7292-7300	NN	denotes	collagen
T9273	7290-7291	CD	denotes	I
T9274	7300-7302	,	denotes	,
T9275	7302-7307	NN	denotes	runx2
T9276	7307-7309	,	denotes	,
T9277	7309-7312	CC	denotes	and
T9278	7313-7320	NN	denotes	osterix
T9279	7321-7326	NNS	denotes	genes
T9280	7327-7329	IN	denotes	at
T9281	7330-7334	CC	denotes	both
T9282	7337-7339	NN	denotes	wk
T9283	7335-7336	CD	denotes	1
T9284	7340-7343	CC	denotes	and
T9285	7344-7345	CD	denotes	3
T9286	7346-7349	NNS	denotes	wks
T9287	7350-7355	IN	denotes	after
T9288	7356-7361	NN	denotes	birth
T9289	7362-7363	-LRB-	denotes	(
T9290	7370-7372	NN	denotes	7A
T9291	7363-7369	NN	denotes	Figure
T9292	7372-7373	SYM	denotes	–
T9293	7373-7375	NN	denotes	7D
T9294	7376-7379	CC	denotes	and
T9295	7380-7382	NN	denotes	7I
T9296	7382-7383	SYM	denotes	–
T9297	7383-7385	NN	denotes	7L
T9298	7385-7386	-RRB-	denotes	)
T9299	7386-7387	.	denotes	.
T9300	7387-7533	sentence	denotes	In the absence of BMP2 and BMP4, cells which are fibroblastic in appearance (Figure 6H) are found adjacent to the mineralized cartilage surfaces.
T9301	7388-7390	IN	denotes	In
T9302	7480-7485	VBN	denotes	found
T9303	7391-7394	DT	denotes	the
T9304	7395-7402	NN	denotes	absence
T9305	7403-7405	IN	denotes	of
T9306	7406-7410	NN	denotes	BMP2
T9307	7411-7414	CC	denotes	and
T9308	7415-7419	NN	denotes	BMP4
T9309	7419-7421	,	denotes	,
T9310	7421-7426	NNS	denotes	cells
T9311	7427-7432	WDT	denotes	which
T9312	7433-7436	VBP	denotes	are
T9313	7437-7449	JJ	denotes	fibroblastic
T9314	7450-7452	IN	denotes	in
T9315	7453-7463	NN	denotes	appearance
T9316	7464-7465	-LRB-	denotes	(
T9317	7472-7474	NN	denotes	6H
T9318	7465-7471	NN	denotes	Figure
T9319	7474-7475	-RRB-	denotes	)
T9320	7476-7479	VBP	denotes	are
T9321	7486-7494	JJ	denotes	adjacent
T9322	7495-7497	IN	denotes	to
T9323	7498-7501	DT	denotes	the
T9324	7524-7532	NNS	denotes	surfaces
T9325	7502-7513	VBN	denotes	mineralized
T9326	7514-7523	NN	denotes	cartilage
T9327	7532-7533	.	denotes	.
T9328	7533-7747	sentence	denotes	These cells express amounts of type I collagen and runx2 comparable to control osteoblasts, but their expression of osterix, while noticeable at 1 wk, becomes almost undetectable at 3 wks (Figure 7E–7H and 7M–7P).
T9329	7534-7539	DT	denotes	These
T9330	7540-7545	NNS	denotes	cells
T9331	7546-7553	VBP	denotes	express
T9332	7554-7561	NNS	denotes	amounts
T9333	7562-7564	IN	denotes	of
T9334	7565-7569	NN	denotes	type
T9335	7572-7580	NN	denotes	collagen
T9336	7570-7571	CD	denotes	I
T9337	7581-7584	CC	denotes	and
T9338	7585-7590	NN	denotes	runx2
T9339	7591-7601	JJ	denotes	comparable
T9340	7602-7604	IN	denotes	to
T9341	7605-7612	NN	denotes	control
T9342	7613-7624	NNS	denotes	osteoblasts
T9343	7624-7626	,	denotes	,
T9344	7626-7629	CC	denotes	but
T9345	7630-7635	PRP$	denotes	their
T9346	7636-7646	NN	denotes	expression
T9347	7685-7692	VBZ	denotes	becomes
T9348	7647-7649	IN	denotes	of
T9349	7650-7657	NN	denotes	osterix
T9350	7657-7659	,	denotes	,
T9351	7659-7664	IN	denotes	while
T9352	7665-7675	JJ	denotes	noticeable
T9353	7676-7678	IN	denotes	at
T9354	7679-7680	CD	denotes	1
T9355	7681-7683	NN	denotes	wk
T9356	7683-7685	,	denotes	,
T9357	7693-7699	RB	denotes	almost
T9358	7700-7712	JJ	denotes	undetectable
T9359	7713-7715	IN	denotes	at
T9360	7716-7717	CD	denotes	3
T9361	7718-7721	NNS	denotes	wks
T9362	7722-7723	-LRB-	denotes	(
T9363	7730-7732	NN	denotes	7E
T9364	7723-7729	NN	denotes	Figure
T9365	7732-7733	SYM	denotes	–
T9366	7733-7735	NN	denotes	7H
T9367	7736-7739	CC	denotes	and
T9368	7740-7742	NN	denotes	7M
T9369	7742-7743	SYM	denotes	–
T9370	7743-7745	NN	denotes	7P
T9371	7745-7746	-RRB-	denotes	)
T9372	7746-7747	.	denotes	.
T9373	7747-7962	sentence	denotes	These results allow us to conclude that the fibroblast-like cells resident in the bone shaft (Figure 6H) may be osteoprogenitor cells unable to differentiate into mature osteoblasts in the absence of BMP2 and BMP4.
T9374	7748-7753	DT	denotes	These
T9375	7754-7761	NNS	denotes	results
T9376	7762-7767	VBP	denotes	allow
T9377	7768-7770	PRP	denotes	us
T9378	7774-7782	VB	denotes	conclude
T9379	7771-7773	TO	denotes	to
T9380	7783-7787	IN	denotes	that
T9381	7857-7859	VB	denotes	be
T9382	7788-7791	DT	denotes	the
T9383	7808-7813	NNS	denotes	cells
T9384	7792-7802	NN	denotes	fibroblast
T9385	7803-7807	JJ	denotes	like
T9386	7802-7803	HYPH	denotes	-
T9387	7814-7822	JJ	denotes	resident
T9388	7823-7825	IN	denotes	in
T9389	7826-7829	DT	denotes	the
T9390	7835-7840	NN	denotes	shaft
T9391	7830-7834	NN	denotes	bone
T9392	7841-7842	-LRB-	denotes	(
T9393	7849-7851	NN	denotes	6H
T9394	7842-7848	NN	denotes	Figure
T9395	7851-7852	-RRB-	denotes	)
T9396	7853-7856	MD	denotes	may
T9397	7860-7875	NN	denotes	osteoprogenitor
T9398	7876-7881	NNS	denotes	cells
T9399	7882-7888	JJ	denotes	unable
T9400	7889-7891	TO	denotes	to
T9401	7892-7905	VB	denotes	differentiate
T9402	7906-7910	IN	denotes	into
T9403	7911-7917	JJ	denotes	mature
T9404	7918-7929	NNS	denotes	osteoblasts
T9405	7930-7932	IN	denotes	in
T9406	7933-7936	DT	denotes	the
T9407	7937-7944	NN	denotes	absence
T9408	7945-7947	IN	denotes	of
T9409	7948-7952	NN	denotes	BMP2
T9410	7953-7956	CC	denotes	and
T9411	7957-7961	NN	denotes	BMP4
T9412	7961-7962	.	denotes	.
R5243	T8396	T8397	nsubjpass	Osteogenesis,Initiated
R5244	T8398	T8397	auxpass	Is,Initiated
R5245	T8399	T8397	advmod	Normally,Initiated
R5246	T8400	T8397	prep	in,Initiated
R5247	T8401	T8402	nmod	BMP2,BMP4
R5248	T8402	T8404	npadvmod	BMP4,Deficient
R5249	T8403	T8402	punct	", ",BMP4
R5250	T8404	T8406	amod	Deficient,Buds
R5251	T8405	T8404	punct	–,Deficient
R5252	T8406	T8400	pobj	Buds,in
R5253	T8407	T8406	compound	Limb,Buds
R5254	T8409	T8410	compound	Bone,formation
R5255	T8410	T8411	nsubj	formation,occurs
R5256	T8412	T8411	advmod	first,occurs
R5257	T8413	T8411	prep	at,occurs
R5258	T8414	T8415	det	the,interface
R5259	T8415	T8413	pobj	interface,at
R5260	T8416	T8415	prep	between,interface
R5261	T8417	T8418	det	the,chondrocytes
R5262	T8418	T8416	pobj	chondrocytes,between
R5263	T8419	T8418	amod	late,chondrocytes
R5264	T8420	T8418	amod	hypertrophic,chondrocytes
R5265	T8421	T8418	cc	and,chondrocytes
R5266	T8422	T8423	det	the,perichondrium
R5267	T8423	T8418	conj	perichondrium,chondrocytes
R5268	T8424	T8423	amod	surrounding,perichondrium
R5269	T8425	T8415	punct	", ",interface
R5270	T8426	T8427	det	a,region
R5271	T8427	T8415	appos	region,interface
R5272	T8428	T8427	acl	identified,region
R5273	T8429	T8428	prep	as,identified
R5274	T8430	T8431	det	the,collar
R5275	T8431	T8429	pobj	collar,as
R5276	T8432	T8431	compound	bone,collar
R5277	T8433	T8411	punct	.,occurs
R5278	T8435	T8436	nsubj	We,examined
R5279	T8437	T8438	mark	whether,initiated
R5280	T8438	T8436	ccomp	initiated,examined
R5281	T8439	T8440	det	the,program
R5282	T8440	T8438	nsubjpass	program,initiated
R5283	T8441	T8440	compound	osteogenesis,program
R5284	T8442	T8438	auxpass	is,initiated
R5285	T8443	T8438	prep	in,initiated
R5286	T8444	T8445	det	the,limbs
R5287	T8445	T8443	pobj	limbs,in
R5288	T8446	T8447	nmod	BMP2,BMP4
R5289	T8447	T8449	npadvmod	BMP4,deficient
R5290	T8448	T8447	punct	", ",BMP4
R5291	T8449	T8445	amod	deficient,limbs
R5292	T8450	T8449	punct	–,deficient
R5293	T8451	T8436	advcl	using,examined
R5294	T8452	T8453	amod	several,criteria
R5295	T8453	T8451	dobj	criteria,using
R5296	T8454	T8453	amod	histological,criteria
R5297	T8455	T8454	cc	and,histological
R5298	T8456	T8454	conj	molecular,histological
R5299	T8457	T8451	punct	", ",using
R5300	T8458	T8459	mark	as,described
R5301	T8459	T8451	advcl	described,using
R5302	T8460	T8459	advmod	below,described
R5303	T8461	T8462	punct	(,Figure
R5304	T8462	T8459	parataxis	Figure,described
R5305	T8463	T8462	nummod	5,Figure
R5306	T8464	T8462	punct	),Figure
R5307	T8465	T8436	punct	.,examined
R5308	T8467	T8468	advcl	Adjacent,laid
R5309	T8469	T8467	prep	to,Adjacent
R5310	T8470	T8471	det	the,cells
R5311	T8471	T8469	pobj	cells,to
R5312	T8472	T8471	amod	hypertrophic,cells
R5313	T8473	T8468	punct	", ",laid
R5314	T8474	T8475	det	a,collar
R5315	T8475	T8468	nsubjpass	collar,laid
R5316	T8476	T8475	compound	bone,collar
R5317	T8477	T8468	auxpass	is,laid
R5318	T8478	T8468	prt	down,laid
R5319	T8479	T8468	advmod	normally,laid
R5320	T8480	T8468	prep	in,laid
R5321	T8481	T8482	det	the,absence
R5322	T8482	T8480	pobj	absence,in
R5323	T8483	T8482	prep	of,absence
R5324	T8484	T8483	pobj	BMP2,of
R5325	T8485	T8484	cc	and,BMP2
R5326	T8486	T8484	conj	BMP4,BMP2
R5327	T8487	T8488	punct	(,star
R5328	T8488	T8468	parataxis	star,laid
R5329	T8489	T8490	compound	Figure,5A
R5330	T8490	T8488	dep	5A,star
R5331	T8491	T8490	cc	and,5A
R5332	T8492	T8490	conj	5B,5A
R5333	T8493	T8488	punct	", ",star
R5334	T8494	T8488	amod	red,star
R5335	T8495	T8488	punct	),star
R5336	T8496	T8468	punct	.,laid
R5337	T8498	T8499	mark	As,seen
R5338	T8499	T8502	advcl	seen,express
R5339	T8500	T8499	aux	can,seen
R5340	T8501	T8499	auxpass	be,seen
R5341	T8503	T8499	prep	in,seen
R5342	T8504	T8505	amod	sagittal,sections
R5343	T8505	T8503	pobj	sections,in
R5344	T8506	T8499	prep	through,seen
R5345	T8507	T8508	det	an,humerus
R5346	T8508	T8506	pobj	humerus,through
R5347	T8509	T8508	compound	E15.5,humerus
R5348	T8510	T8502	punct	", ",express
R5349	T8511	T8512	det	the,cells
R5350	T8512	T8502	nsubj	cells,express
R5351	T8513	T8512	acl	embedded,cells
R5352	T8514	T8513	prep	in,embedded
R5353	T8515	T8516	det	the,matrix
R5354	T8516	T8514	pobj	matrix,in
R5355	T8517	T8516	amod	mineralized,matrix
R5356	T8518	T8519	det	the,marker
R5357	T8519	T8502	dobj	marker,express
R5358	T8520	T8519	compound	osteoblast,marker
R5359	T8521	T8519	appos	Col,marker
R5360	T8522	T8521	nummod	I,Col
R5361	T8523	T8502	prep	as,express
R5362	T8524	T8523	amod	normal,as
R5363	T8525	T8526	punct	(,5C
R5364	T8526	T8502	parataxis	5C,express
R5365	T8527	T8526	compound	Figure,5C
R5366	T8528	T8526	cc	and,5C
R5367	T8529	T8526	conj	5D,5C
R5368	T8530	T8526	punct	),5C
R5369	T8531	T8502	punct	.,express
R5370	T8533	T8534	prep	By,undergoes
R5371	T8535	T8533	pobj	E17.5,By
R5372	T8536	T8534	punct	", ",undergoes
R5373	T8537	T8538	det	the,cartilage
R5374	T8538	T8534	nsubj	cartilage,undergoes
R5375	T8539	T8538	amod	mineralized,cartilage
R5376	T8540	T8541	dep	that,makes
R5377	T8541	T8538	relcl	makes,cartilage
R5378	T8542	T8541	prt	up,makes
R5379	T8543	T8544	det	the,zone
R5380	T8544	T8541	dobj	zone,makes
R5381	T8545	T8544	amod	late,zone
R5382	T8546	T8544	amod	hypertrophic,zone
R5383	T8547	T8544	prep	of,zone
R5384	T8548	T8549	det	the,plate
R5385	T8549	T8547	pobj	plate,of
R5386	T8550	T8549	compound	growth,plate
R5387	T8551	T8534	advmod	normally,undergoes
R5388	T8552	T8534	dobj	removal,undergoes
R5389	T8553	T8552	prep	by,removal
R5390	T8554	T8553	pobj	osteoclasts,by
R5391	T8555	T8556	punct	(,arrows
R5392	T8556	T8534	parataxis	arrows,undergoes
R5393	T8557	T8558	compound	Figure,5G
R5394	T8558	T8556	dep	5G,arrows
R5395	T8559	T8556	punct	", ",arrows
R5396	T8560	T8561	amod	brown,stained
R5397	T8561	T8563	amod	stained,cells
R5398	T8562	T8561	punct	-,stained
R5399	T8563	T8556	dep	cells,arrows
R5400	T8564	T8556	punct	", ",arrows
R5401	T8565	T8556	amod	red,arrows
R5402	T8566	T8556	punct	),arrows
R5403	T8567	T8534	punct	", ",undergoes
R5404	T8568	T8534	advcl	resulting,undergoes
R5405	T8569	T8568	prep	in,resulting
R5406	T8570	T8571	det	the,formation
R5407	T8571	T8569	pobj	formation,in
R5408	T8572	T8571	prep	of,formation
R5409	T8573	T8574	det	a,cavity
R5410	T8574	T8572	pobj	cavity,of
R5411	T8575	T8576	compound	bone,marrow
R5412	T8576	T8574	compound	marrow,cavity
R5413	T8577	T8578	punct	(,arrow
R5414	T8578	T8534	parataxis	arrow,undergoes
R5415	T8579	T8578	amod	red,arrow
R5416	T8580	T8578	prep	in,arrow
R5417	T8581	T8582	compound	Figure,5E
R5418	T8582	T8580	pobj	5E,in
R5419	T8583	T8582	cc	and,5E
R5420	T8584	T8582	conj	5I,5E
R5421	T8585	T8578	punct	", ",arrow
R5422	T8586	T8578	advcl	see,arrow
R5423	T8587	T8586	advmod	also,see
R5424	T8588	T8586	dobj	Figure,see
R5425	T8589	T8588	nummod	6,Figure
R5426	T8590	T8578	punct	),arrow
R5427	T8591	T8534	punct	.,undergoes
R5428	T8593	T8594	compound	Osteoprogenitor,cells
R5429	T8594	T8595	nsubj	cells,populate
R5430	T8596	T8594	prep	from,cells
R5431	T8597	T8598	compound	bone,region
R5432	T8598	T8596	pobj	region,from
R5433	T8599	T8598	compound	collar,region
R5434	T8600	T8595	advmod	now,populate
R5435	T8601	T8602	det	this,site
R5436	T8602	T8595	dobj	site,populate
R5437	T8603	T8595	cc	and,populate
R5438	T8604	T8595	conj	deposit,populate
R5439	T8605	T8604	dobj	osteoid,deposit
R5440	T8606	T8595	punct	", ",populate
R5441	T8607	T8595	advcl	forming,populate
R5442	T8608	T8609	det	the,bone
R5443	T8609	T8607	dobj	bone,forming
R5444	T8610	T8609	amod	trabecular,bone
R5445	T8611	T8609	prep	in,bone
R5446	T8612	T8613	det	the,cavity
R5447	T8613	T8611	pobj	cavity,in
R5448	T8614	T8613	compound	bone,cavity
R5449	T8615	T8613	compound	marrow,cavity
R5450	T8616	T8617	punct	(,arrow
R5451	T8617	T8613	parataxis	arrow,cavity
R5452	T8618	T8619	compound	Figure,6E
R5453	T8619	T8617	dep	6E,arrow
R5454	T8620	T8617	punct	", ",arrow
R5455	T8621	T8617	amod	red,arrow
R5456	T8622	T8617	punct	),arrow
R5457	T8623	T8613	cc	and,cavity
R5458	T8624	T8625	amod	cortical,bone
R5459	T8625	T8613	conj	bone,cavity
R5460	T8626	T8607	prep	at,forming
R5461	T8627	T8626	pobj	birth,at
R5462	T8628	T8629	punct	(,asterisk
R5463	T8629	T8595	parataxis	asterisk,populate
R5464	T8630	T8631	compound	Figure,5I
R5465	T8631	T8629	dep	5I,asterisk
R5466	T8632	T8629	punct	", ",asterisk
R5467	T8633	T8629	punct	),asterisk
R5468	T8634	T8595	punct	.,populate
R5469	T8636	T8637	prep	In,is
R5470	T8638	T8636	pobj	contrast,In
R5471	T8639	T8637	punct	", ",is
R5472	T8640	T8637	prep	in,is
R5473	T8641	T8642	compound	E17.5,limbs
R5474	T8642	T8640	pobj	limbs,in
R5475	T8643	T8642	amod	deficient,limbs
R5476	T8644	T8643	prep	in,deficient
R5477	T8645	T8644	pobj	BMP2,in
R5478	T8646	T8645	cc	and,BMP2
R5479	T8647	T8645	conj	BMP4,BMP2
R5480	T8648	T8637	punct	", ",is
R5481	T8649	T8637	expl	there,is
R5482	T8650	T8651	det	an,delay
R5483	T8651	T8637	attr	delay,is
R5484	T8652	T8651	amod	overall,delay
R5485	T8653	T8651	prep	in,delay
R5486	T8654	T8655	det	the,process
R5487	T8655	T8653	pobj	process,in
R5488	T8656	T8655	amod	normal,process
R5489	T8657	T8655	amod	endochondral,process
R5490	T8658	T8659	punct	(,5F
R5491	T8659	T8637	parataxis	5F,is
R5492	T8660	T8659	compound	Figure,5F
R5493	T8661	T8659	punct	),5F
R5494	T8662	T8637	punct	.,is
R5495	T8664	T8665	mark	While,occurs
R5496	T8665	T8667	advcl	occurs,recruited
R5497	T8666	T8665	nsubj	vascularization,occurs
R5498	T8668	T8665	prep	in,occurs
R5499	T8669	T8670	nmod	Bmp2C,C
R5500	T8670	T8672	nmod	C,forelimbs
R5501	T8671	T8670	punct	/,C
R5502	T8672	T8668	pobj	forelimbs,in
R5503	T8673	T8670	punct	;,C
R5504	T8674	T8675	compound	Bmp4C,C
R5505	T8675	T8670	appos	C,C
R5506	T8676	T8675	punct	/,C
R5507	T8677	T8670	punct	;,C
R5508	T8678	T8679	compound	Prx1,cre
R5509	T8679	T8670	appos	cre,C
R5510	T8680	T8679	punct	:,cre
R5511	T8681	T8679	punct	:,cre
R5512	T8682	T8667	punct	", ",recruited
R5513	T8683	T8684	amod	few,osteoclasts
R5514	T8684	T8667	nsubjpass	osteoclasts,recruited
R5515	T8685	T8667	auxpass	are,recruited
R5516	T8686	T8667	prep	to,recruited
R5517	T8687	T8688	det	the,cartilage
R5518	T8688	T8686	pobj	cartilage,to
R5519	T8689	T8688	amod	mineralized,cartilage
R5520	T8690	T8691	punct	(,arrows
R5521	T8691	T8667	parataxis	arrows,recruited
R5522	T8692	T8691	advcl	compare,arrows
R5523	T8693	T8694	compound	Figure,5G
R5524	T8694	T8692	dobj	5G,compare
R5525	T8695	T8694	cc	and,5G
R5526	T8696	T8697	compound	Figure,5H
R5527	T8697	T8694	conj	5H,5G
R5528	T8698	T8691	punct	", ",arrows
R5529	T8699	T8691	amod	red,arrows
R5530	T8700	T8691	punct	),arrows
R5531	T8701	T8667	punct	", ",recruited
R5532	T8702	T8667	advcl	resulting,recruited
R5533	T8703	T8702	prep	in,resulting
R5534	T8704	T8705	det	a,delay
R5535	T8705	T8703	pobj	delay,in
R5536	T8706	T8705	prep	in,delay
R5537	T8707	T8708	compound	bone,marrow
R5538	T8708	T8709	compound	marrow,formation
R5539	T8709	T8706	pobj	formation,in
R5540	T8710	T8709	compound	cavity,formation
R5541	T8711	T8702	prep	in,resulting
R5542	T8712	T8713	det	the,absence
R5543	T8713	T8711	pobj	absence,in
R5544	T8714	T8713	prep	of,absence
R5545	T8715	T8714	pobj	BMP2,of
R5546	T8716	T8715	cc	and,BMP2
R5547	T8717	T8715	conj	BMP4,BMP2
R5548	T8718	T8667	punct	.,recruited
R5549	T8720	T8721	prep	In,started
R5550	T8722	T8720	pobj	fact,In
R5551	T8723	T8721	punct	", ",started
R5552	T8724	T8725	compound	bone,marrow
R5553	T8725	T8726	compound	marrow,formation
R5554	T8726	T8721	nsubj	formation,started
R5555	T8727	T8726	cc	and,formation
R5556	T8728	T8729	amod	trabecular,formation
R5557	T8729	T8726	conj	formation,formation
R5558	T8730	T8729	compound	bone,formation
R5559	T8731	T8721	aux	have,started
R5560	T8732	T8721	neg	not,started
R5561	T8733	T8721	advmod	yet,started
R5562	T8734	T8721	prep	at,started
R5563	T8735	T8734	pobj	birth,at
R5564	T8736	T8721	prep	in,started
R5565	T8737	T8738	det	the,absence
R5566	T8738	T8736	pobj	absence,in
R5567	T8739	T8738	prep	of,absence
R5568	T8740	T8739	pobj	BMP2,of
R5569	T8741	T8740	cc	and,BMP2
R5570	T8742	T8740	conj	BMP4,BMP2
R5571	T8743	T8744	punct	(,5J
R5572	T8744	T8721	parataxis	5J,started
R5573	T8745	T8744	compound	Figure,5J
R5574	T8746	T8744	punct	),5J
R5575	T8747	T8721	punct	", ",started
R5576	T8748	T8721	cc	and,started
R5577	T8749	T8750	det	the,morphology
R5578	T8750	T8751	nsubj	morphology,is
R5579	T8751	T8721	conj	is,started
R5580	T8752	T8750	prep	of,morphology
R5581	T8753	T8754	nmod	Bmp2C,C
R5582	T8754	T8756	nmod	C,bones
R5583	T8755	T8754	punct	/,C
R5584	T8756	T8752	pobj	bones,of
R5585	T8757	T8754	punct	;,C
R5586	T8758	T8759	compound	Bmp4C,C
R5587	T8759	T8754	appos	C,C
R5588	T8760	T8759	punct	/,C
R5589	T8761	T8754	punct	;,C
R5590	T8762	T8763	compound	Prx1,cre
R5591	T8763	T8754	appos	cre,C
R5592	T8764	T8763	punct	:,cre
R5593	T8765	T8763	punct	:,cre
R5594	T8766	T8756	prep	at,bones
R5595	T8767	T8766	pobj	birth,at
R5596	T8768	T8769	advmod	most,similar
R5597	T8769	T8751	acomp	similar,is
R5598	T8770	T8769	prep	to,similar
R5599	T8771	T8772	compound	control,embryos
R5600	T8772	T8770	pobj	embryos,to
R5601	T8773	T8772	prep	at,embryos
R5602	T8774	T8773	pobj	E17.5,at
R5603	T8775	T8776	punct	(,5E
R5604	T8776	T8721	parataxis	5E,started
R5605	T8777	T8776	compound	Figure,5E
R5606	T8778	T8776	punct	),5E
R5607	T8779	T8721	punct	.,started
R5608	T8781	T8782	aux	To,differentiate
R5609	T8782	T8783	advcl	differentiate,performed
R5610	T8784	T8782	prep	between,differentiate
R5611	T8785	T8786	det	a,delay
R5612	T8786	T8784	pobj	delay,between
R5613	T8787	T8786	amod	simple,delay
R5614	T8788	T8786	prep	in,delay
R5615	T8789	T8790	compound	bone,formation
R5616	T8790	T8788	pobj	formation,in
R5617	T8791	T8786	prep	in,delay
R5618	T8792	T8793	det	the,absence
R5619	T8793	T8791	pobj	absence,in
R5620	T8794	T8793	prep	of,absence
R5621	T8795	T8794	pobj	BMP2,of
R5622	T8796	T8795	cc	and,BMP2
R5623	T8797	T8795	conj	BMP4,BMP2
R5624	T8798	T8786	cc	and,delay
R5625	T8799	T8800	det	the,inability
R5626	T8800	T8786	conj	inability,delay
R5627	T8801	T8802	aux	to,form
R5628	T8802	T8800	acl	form,inability
R5629	T8803	T8802	dobj	bone,form
R5630	T8804	T8803	prep	without,bone
R5631	T8805	T8806	det	these,BMPs
R5632	T8806	T8804	pobj	BMPs,without
R5633	T8807	T8783	punct	", ",performed
R5634	T8808	T8783	nsubj	we,performed
R5635	T8809	T8810	amod	histological,analyses
R5636	T8810	T8783	dobj	analyses,performed
R5637	T8811	T8783	prep	in,performed
R5638	T8812	T8813	nmod	Bmp2C,C
R5639	T8813	T8815	nmod	C,mice
R5640	T8814	T8813	punct	/,C
R5641	T8815	T8811	pobj	mice,in
R5642	T8816	T8813	punct	;,C
R5643	T8817	T8818	compound	Bmp4C,C
R5644	T8818	T8813	appos	C,C
R5645	T8819	T8818	punct	/,C
R5646	T8820	T8813	punct	;,C
R5647	T8821	T8822	compound	Prx1,cre
R5648	T8822	T8813	appos	cre,C
R5649	T8823	T8822	punct	:,cre
R5650	T8824	T8822	punct	:,cre
R5651	T8825	T8826	advmod	up,3
R5652	T8826	T8828	nummod	3,wks
R5653	T8827	T8826	quantmod	to,3
R5654	T8828	T8815	npadvmod	wks,mice
R5655	T8829	T8828	prep	of,wks
R5656	T8830	T8829	pobj	age,of
R5657	T8831	T8783	punct	.,performed
R5658	T8833	T8834	mark	As,shown
R5659	T8834	T8835	advcl	shown,found
R5660	T8836	T8834	prep	in,shown
R5661	T8837	T8838	compound	Figure,6A
R5662	T8838	T8836	pobj	6A,in
R5663	T8839	T8838	prep	through,6A
R5664	T8840	T8839	pobj	6E,through
R5665	T8841	T8835	punct	", ",found
R5666	T8842	T8835	prep	in,found
R5667	T8843	T8844	det	the,mice
R5668	T8844	T8842	pobj	mice,in
R5669	T8845	T8844	compound	control,mice
R5670	T8846	T8835	punct	", ",found
R5671	T8847	T8848	det	a,collar
R5672	T8848	T8835	nsubjpass	collar,found
R5673	T8849	T8848	compound	bone,collar
R5674	T8850	T8835	auxpass	is,found
R5675	T8851	T8835	oprd	adjacent,found
R5676	T8852	T8851	prep	to,adjacent
R5677	T8853	T8854	det	the,zone
R5678	T8854	T8852	pobj	zone,to
R5679	T8855	T8854	prep	of,zone
R5680	T8856	T8857	amod	late,chondrocytes
R5681	T8857	T8855	pobj	chondrocytes,of
R5682	T8858	T8857	amod	hypertrophic,chondrocytes
R5683	T8859	T8835	prep	at,found
R5684	T8860	T8861	nummod	1,wk
R5685	T8861	T8859	pobj	wk,at
R5686	T8862	T8863	punct	(,6A
R5687	T8863	T8835	parataxis	6A,found
R5688	T8864	T8863	compound	Figure,6A
R5689	T8865	T8863	cc	and,6A
R5690	T8866	T8863	conj	6B,6A
R5691	T8867	T8863	punct	),6A
R5692	T8868	T8835	punct	.,found
R5693	T8870	T8871	amod	Many,osteoblasts
R5694	T8871	T8872	nsubj	osteoblasts,line
R5695	T8873	T8874	det	the,bone
R5696	T8874	T8872	dobj	bone,line
R5697	T8875	T8876	advmod	newly,formed
R5698	T8876	T8874	amod	formed,bone
R5699	T8877	T8874	amod	cortical,bone
R5700	T8878	T8874	prep	in,bone
R5701	T8879	T8880	det	the,region
R5702	T8880	T8878	pobj	region,in
R5703	T8881	T8880	amod	diaphyseal,region
R5704	T8882	T8883	punct	(,arrow
R5705	T8883	T8872	parataxis	arrow,line
R5706	T8884	T8885	compound	Figure,6C
R5707	T8885	T8883	dep	6C,arrow
R5708	T8886	T8883	punct	", ",arrow
R5709	T8887	T8883	amod	blue,arrow
R5710	T8888	T8883	punct	),arrow
R5711	T8889	T8872	punct	", ",line
R5712	T8890	T8872	cc	and,line
R5713	T8891	T8892	nsubj	formation,begun
R5714	T8892	T8872	conj	begun,line
R5715	T8893	T8891	prep	of,formation
R5716	T8894	T8895	det	a,center
R5717	T8895	T8893	pobj	center,of
R5718	T8896	T8895	amod	secondary,center
R5719	T8897	T8895	compound	ossification,center
R5720	T8898	T8892	aux	has,begun
R5721	T8899	T8900	punct	(,star
R5722	T8900	T8892	parataxis	star,begun
R5723	T8901	T8902	compound	Figure,6A
R5724	T8902	T8900	dep	6A,star
R5725	T8903	T8900	punct	", ",star
R5726	T8904	T8900	amod	red,star
R5727	T8905	T8900	punct	),star
R5728	T8906	T8892	punct	.,begun
R5729	T8908	T8909	prep	At,is
R5730	T8910	T8911	nummod	3,wks
R5731	T8911	T8908	pobj	wks,At
R5732	T8912	T8911	prep	of,wks
R5733	T8913	T8912	pobj	age,of
R5734	T8914	T8909	punct	", ",is
R5735	T8915	T8909	nsubj	formation,is
R5736	T8916	T8915	prep	of,formation
R5737	T8917	T8918	det	the,center
R5738	T8918	T8916	pobj	center,of
R5739	T8919	T8918	amod	secondary,center
R5740	T8920	T8918	compound	ossification,center
R5741	T8921	T8909	acomp	complete,is
R5742	T8922	T8923	punct	(,star
R5743	T8923	T8909	parataxis	star,is
R5744	T8924	T8925	compound	Figure,6D
R5745	T8925	T8923	dep	6D,star
R5746	T8926	T8923	punct	", ",star
R5747	T8927	T8923	amod	red,star
R5748	T8928	T8923	punct	),star
R5749	T8929	T8909	punct	", ",is
R5750	T8930	T8909	prep	along,is
R5751	T8931	T8930	prep	with,along
R5752	T8932	T8933	amod	robust,formation
R5753	T8933	T8931	pobj	formation,with
R5754	T8934	T8935	compound	bone,marrow
R5755	T8935	T8933	compound	marrow,formation
R5756	T8936	T8937	punct	(,bm
R5757	T8937	T8933	parataxis	bm,formation
R5758	T8938	T8939	compound	Figure,6D
R5759	T8939	T8937	dep	6D,bm
R5760	T8940	T8937	punct	", ",bm
R5761	T8941	T8937	punct	),bm
R5762	T8942	T8933	cc	and,formation
R5763	T8943	T8933	conj	deposition,formation
R5764	T8944	T8943	prep	of,deposition
R5765	T8945	T8946	amod	trabecular,bone
R5766	T8946	T8944	pobj	bone,of
R5767	T8947	T8948	punct	(,tissue
R5768	T8948	T8909	parataxis	tissue,is
R5769	T8949	T8950	compound	Figure,6E
R5770	T8950	T8948	dep	6E,tissue
R5771	T8951	T8948	punct	", ",tissue
R5772	T8952	T8948	amod	pale,tissue
R5773	T8953	T8948	amod	blue,tissue
R5774	T8954	T8948	acl	marked,tissue
R5775	T8955	T8954	agent	by,marked
R5776	T8956	T8957	amod	red,arrow
R5777	T8957	T8955	pobj	arrow,by
R5778	T8958	T8948	punct	),tissue
R5779	T8959	T8909	punct	.,is
R5780	T8961	T8962	prep	In,observed
R5781	T8963	T8964	amod	stark,contrast
R5782	T8964	T8961	pobj	contrast,In
R5783	T8965	T8962	punct	", ",observed
R5784	T8966	T8967	compound	bone,formation
R5785	T8967	T8962	nsubjpass	formation,observed
R5786	T8968	T8962	auxpass	is,observed
R5787	T8969	T8962	neg	not,observed
R5788	T8970	T8962	prep	in,observed
R5789	T8971	T8972	det	the,absence
R5790	T8972	T8970	pobj	absence,in
R5791	T8973	T8972	prep	of,absence
R5792	T8974	T8973	pobj	BMP2,of
R5793	T8975	T8974	cc	and,BMP2
R5794	T8976	T8974	conj	BMP4,BMP2
R5795	T8977	T8962	prep	at,observed
R5796	T8978	T8979	nummod	1,wks
R5797	T8979	T8977	pobj	wks,at
R5798	T8980	T8978	cc	or,1
R5799	T8981	T8978	conj	3,1
R5800	T8982	T8979	prep	after,wks
R5801	T8983	T8982	pobj	birth,after
R5802	T8984	T8985	punct	(,6F
R5803	T8985	T8962	parataxis	6F,observed
R5804	T8986	T8985	compound	Figure,6F
R5805	T8987	T8988	punct	–,6J
R5806	T8988	T8985	prep	6J,6F
R5807	T8989	T8985	punct	),6F
R5808	T8990	T8962	punct	.,observed
R5809	T8992	T8993	det	The,appearance
R5810	T8993	T8994	nsubj	appearance,remains
R5811	T8995	T8993	prep	of,appearance
R5812	T8996	T8997	det	the,elements
R5813	T8997	T8995	pobj	elements,of
R5814	T8998	T8997	amod	skeletal,elements
R5815	T8999	T8993	prep	in,appearance
R5816	T9000	T9001	det	the,mutants
R5817	T9001	T8999	pobj	mutants,in
R5818	T9002	T9001	amod	double,mutants
R5819	T9003	T8994	acomp	similar,remains
R5820	T9004	T9003	prep	to,similar
R5821	T9005	T9006	compound	E17.5,structures
R5822	T9006	T9004	pobj	structures,to
R5823	T9007	T9006	acl	seen,structures
R5824	T9008	T9007	prep	in,seen
R5825	T9009	T9010	amod	wild,type
R5826	T9010	T9012	compound	type,limbs
R5827	T9011	T9010	punct	-,type
R5828	T9012	T9008	pobj	limbs,in
R5829	T9013	T9014	punct	(,5E
R5830	T9014	T9007	parataxis	5E,seen
R5831	T9015	T9014	compound	Figure,5E
R5832	T9016	T9014	punct	),5E
R5833	T9017	T8994	punct	", ",remains
R5834	T9018	T8994	cc	and,remains
R5835	T9019	T9020	mark	although,is
R5836	T9020	T9022	advcl	is,is
R5837	T9021	T9020	expl	there,is
R5838	T9022	T8994	conj	is,remains
R5839	T9023	T9024	det	a,collar
R5840	T9024	T9020	attr	collar,is
R5841	T9025	T9024	compound	bone,collar
R5842	T9026	T9020	prep	at,is
R5843	T9027	T9028	det	the,site
R5844	T9028	T9026	pobj	site,at
R5845	T9029	T9028	prep	of,site
R5846	T9030	T9031	amod	hypertrophic,cartilage
R5847	T9031	T9029	pobj	cartilage,of
R5848	T9032	T9033	punct	(,6G
R5849	T9033	T9020	parataxis	6G,is
R5850	T9034	T9033	compound	Figure,6G
R5851	T9035	T9033	punct	),6G
R5852	T9036	T9022	punct	", ",is
R5853	T9037	T9038	det	no,cavity
R5854	T9038	T9022	nsubj	cavity,is
R5855	T9039	T9040	compound	bone,marrow
R5856	T9040	T9038	compound	marrow,cavity
R5857	T9041	T9038	punct	", ",cavity
R5858	T9042	T9043	amod	trabecular,bone
R5859	T9043	T9038	conj	bone,cavity
R5860	T9044	T9043	punct	", ",bone
R5861	T9045	T9043	cc	or,bone
R5862	T9046	T9047	amod	cortical,bone
R5863	T9047	T9043	conj	bone,bone
R5864	T9048	T9022	acomp	present,is
R5865	T9049	T9050	punct	(,6F
R5866	T9050	T9022	parataxis	6F,is
R5867	T9051	T9050	compound	Figure,6F
R5868	T9052	T9050	punct	),6F
R5869	T9053	T9022	punct	.,is
R5870	T9055	T9056	amod	Many,osteoclasts
R5871	T9056	T9057	nsubjpass	osteoclasts,recruited
R5872	T9058	T9057	aux	have,recruited
R5873	T9059	T9057	auxpass	been,recruited
R5874	T9060	T9057	prep	to,recruited
R5875	T9061	T9062	det	the,cartilage
R5876	T9062	T9060	pobj	cartilage,to
R5877	T9063	T9062	amod	remaining,cartilage
R5878	T9064	T9062	amod	mineralized,cartilage
R5879	T9065	T9057	cc	and,recruited
R5880	T9066	T9067	aux	are,resorbing
R5881	T9067	T9057	conj	resorbing,recruited
R5882	T9068	T9067	advmod	actively,resorbing
R5883	T9069	T9070	det	this,tissue
R5884	T9070	T9067	dobj	tissue,resorbing
R5885	T9071	T9072	punct	(,6I
R5886	T9072	T9067	parataxis	6I,resorbing
R5887	T9073	T9074	amod	red,asterisks
R5888	T9074	T9072	dep	asterisks,6I
R5889	T9075	T9072	punct	", ",6I
R5890	T9076	T9072	compound	Figure,6I
R5891	T9077	T9072	punct	),6I
R5892	T9078	T9057	punct	", ",recruited
R5893	T9079	T9080	mark	so,disappeared
R5894	T9080	T9057	advcl	disappeared,recruited
R5895	T9081	T9080	mark	that,disappeared
R5896	T9082	T9080	prep	by,disappeared
R5897	T9083	T9084	nummod	3,wks
R5898	T9084	T9082	pobj	wks,by
R5899	T9085	T9080	punct	", ",disappeared
R5900	T9086	T9087	predet	all,cartilage
R5901	T9087	T9080	nsubj	cartilage,disappeared
R5902	T9088	T9087	det	the,cartilage
R5903	T9089	T9087	amod	mineralized,cartilage
R5904	T9090	T9087	prep	in,cartilage
R5905	T9091	T9092	det	the,region
R5906	T9092	T9090	pobj	region,in
R5907	T9093	T9092	amod	diaphyseal,region
R5908	T9094	T9080	aux	has,disappeared
R5909	T9095	T9080	punct	", ",disappeared
R5910	T9096	T9080	advcl	leaving,disappeared
R5911	T9097	T9098	det	a,void
R5912	T9098	T9096	dobj	void,leaving
R5913	T9099	T9100	advmod	where,occurred
R5914	T9100	T9098	relcl	occurred,void
R5915	T9101	T9102	compound	bone,formation
R5916	T9102	T9100	nsubj	formation,occurred
R5917	T9103	T9100	aux	should,occurred
R5918	T9104	T9100	aux	have,occurred
R5919	T9105	T9106	punct	(,6J
R5920	T9106	T9057	parataxis	6J,recruited
R5921	T9107	T9106	compound	Figure,6J
R5922	T9108	T9106	punct	", ",6J
R5923	T9109	T9110	advmod	also,see
R5924	T9110	T9106	advcl	see,6J
R5925	T9111	T9112	compound	Figures,6L
R5926	T9112	T9110	dobj	6L,see
R5927	T9113	T9112	cc	and,6L
R5928	T9114	T9112	conj	S3,6L
R5929	T9115	T9106	punct	),6J
R5930	T9116	T9057	punct	.,recruited
R5931	T9118	T9119	det	This,void
R5932	T9119	T9120	nsubjpass	void,invaded
R5933	T9121	T9120	auxpass	is,invaded
R5934	T9122	T9120	advmod	eventually,invaded
R5935	T9123	T9120	agent	by,invaded
R5936	T9124	T9125	amod	soft,tissues
R5937	T9125	T9123	pobj	tissues,by
R5938	T9126	T9125	cc	and,tissues
R5939	T9127	T9128	det	the,muscle
R5940	T9128	T9125	conj	muscle,tissues
R5941	T9129	T9128	amod	adjacent,muscle
R5942	T9130	T9128	punct	(,muscle
R5943	T9131	T9128	acl	marked,muscle
R5944	T9132	T9131	oprd	s,marked
R5945	T9133	T9132	cc	and,s
R5946	T9134	T9132	conj	m,s
R5947	T9135	T9131	punct	", ",marked
R5948	T9136	T9131	advmod	respectively,marked
R5949	T9137	T9131	punct	", ",marked
R5950	T9138	T9131	prep	in,marked
R5951	T9139	T9140	compound	Figure,6J
R5952	T9140	T9138	pobj	6J,in
R5953	T9141	T9120	punct	),invaded
R5954	T9142	T9120	punct	.,invaded
R5955	T9144	T9145	det	The,resorption
R5956	T9145	T9146	nsubj	resorption,is
R5957	T9147	T9145	prep	of,resorption
R5958	T9148	T9147	pobj	bone,of
R5959	T9149	T9145	prep	at,resorption
R5960	T9150	T9151	nummod	3,wks
R5961	T9151	T9149	pobj	wks,at
R5962	T9152	T9151	prep	of,wks
R5963	T9153	T9152	pobj	age,of
R5964	T9154	T9155	advmod	clearly,visible
R5965	T9155	T9146	acomp	visible,is
R5966	T9156	T9146	prep	in,is
R5967	T9157	T9158	det	the,femur
R5968	T9158	T9156	pobj	femur,in
R5969	T9159	T9158	amod	proximal,femur
R5970	T9160	T9158	prep	of,femur
R5971	T9161	T9162	compound	mutant,animals
R5972	T9162	T9160	pobj	animals,of
R5973	T9163	T9164	advmod	where,is
R5974	T9164	T9158	relcl	is,femur
R5975	T9165	T9166	det	a,portion
R5976	T9166	T9164	nsubj	portion,is
R5977	T9167	T9166	prep	of,portion
R5978	T9168	T9169	det	that,bone
R5979	T9169	T9167	pobj	bone,of
R5980	T9170	T9164	acomp	missing,is
R5981	T9171	T9172	punct	(,arrow
R5982	T9172	T9146	parataxis	arrow,is
R5983	T9173	T9174	compound	Figure,6L
R5984	T9174	T9172	dep	6L,arrow
R5985	T9175	T9172	punct	", ",arrow
R5986	T9176	T9172	amod	black,arrow
R5987	T9177	T9172	punct	),arrow
R5988	T9178	T9146	punct	.,is
R5989	T9180	T9181	det	The,inability
R5990	T9181	T9182	nsubj	inability,results
R5991	T9183	T9184	aux	to,complete
R5992	T9184	T9181	acl	complete,inability
R5993	T9185	T9186	compound	osteoblast,differentiation
R5994	T9186	T9184	dobj	differentiation,complete
R5995	T9187	T9184	prep	in,complete
R5996	T9188	T9189	det	the,mice
R5997	T9189	T9187	pobj	mice,in
R5998	T9190	T9191	nmod	Bmp2C,C
R5999	T9191	T9189	nmod	C,mice
R6000	T9192	T9191	punct	/,C
R6001	T9193	T9191	punct	;,C
R6002	T9194	T9195	compound	Bmp4C,C
R6003	T9195	T9191	appos	C,C
R6004	T9196	T9195	punct	/,C
R6005	T9197	T9191	punct	;,C
R6006	T9198	T9199	compound	Prx1,cre
R6007	T9199	T9191	appos	cre,C
R6008	T9200	T9199	punct	:,cre
R6009	T9201	T9199	punct	:,cre
R6010	T9202	T9182	prep	in,results
R6011	T9203	T9204	advmod	strikingly,defective
R6012	T9204	T9205	amod	defective,morphology
R6013	T9205	T9202	pobj	morphology,in
R6014	T9206	T9205	compound	limb,morphology
R6015	T9207	T9205	prep	at,morphology
R6016	T9208	T9209	nummod	1,wk
R6017	T9209	T9207	pobj	wk,at
R6018	T9210	T9209	prep	of,wk
R6019	T9211	T9210	pobj	age,of
R6020	T9212	T9213	punct	(,compare
R6021	T9213	T9182	parataxis	compare,results
R6022	T9214	T9215	compound	Figure,S3G
R6023	T9215	T9213	dobj	S3G,compare
R6024	T9216	T9215	cc	and,S3G
R6025	T9217	T9215	conj	S3H,S3G
R6026	T9218	T9213	punct	),compare
R6027	T9219	T9182	punct	.,results
R6028	T9221	T9222	aux	To,determine
R6029	T9222	T9223	advcl	determine,examined
R6030	T9224	T9225	mark	if,occurs
R6031	T9225	T9222	ccomp	occurs,determine
R6032	T9226	T9227	det	any,differentiation
R6033	T9227	T9225	nsubj	differentiation,occurs
R6034	T9228	T9227	compound	osteoblast,differentiation
R6035	T9229	T9225	prep	in,occurs
R6036	T9230	T9231	nmod	Bmp2C,C
R6037	T9231	T9233	nmod	C,forelimbs
R6038	T9232	T9231	punct	/,C
R6039	T9233	T9229	pobj	forelimbs,in
R6040	T9234	T9231	punct	;,C
R6041	T9235	T9236	compound	Bmp4C,C
R6042	T9236	T9231	appos	C,C
R6043	T9237	T9236	punct	/,C
R6044	T9238	T9231	punct	;,C
R6045	T9239	T9240	compound	Prx1,cre
R6046	T9240	T9231	appos	cre,C
R6047	T9241	T9240	punct	:,cre
R6048	T9242	T9240	punct	:,cre
R6049	T9243	T9223	punct	", ",examined
R6050	T9244	T9223	nsubj	we,examined
R6051	T9245	T9246	npadvmod	osteoblast,related
R6052	T9246	T9248	amod	related,expression
R6053	T9247	T9246	punct	-,related
R6054	T9248	T9223	dobj	expression,examined
R6055	T9249	T9248	compound	gene,expression
R6056	T9250	T9251	punct	(,Figure
R6057	T9251	T9223	parataxis	Figure,examined
R6058	T9252	T9251	nummod	7,Figure
R6059	T9253	T9251	punct	),Figure
R6060	T9254	T9223	punct	.,examined
R6061	T9256	T9257	prep	In,express
R6062	T9258	T9259	det	the,mice
R6063	T9259	T9256	pobj	mice,In
R6064	T9260	T9259	compound	control,mice
R6065	T9261	T9257	punct	", ",express
R6066	T9262	T9257	nsubj	osteoblasts,express
R6067	T9263	T9262	acl	lining,osteoblasts
R6068	T9264	T9265	det	the,surface
R6069	T9265	T9263	dobj	surface,lining
R6070	T9266	T9265	prep	of,surface
R6071	T9267	T9268	amod	trabecular,bone
R6072	T9268	T9266	pobj	bone,of
R6073	T9269	T9267	cc	and,trabecular
R6074	T9270	T9267	conj	cortical,trabecular
R6075	T9271	T9272	nmod	type,collagen
R6076	T9272	T9257	dobj	collagen,express
R6077	T9273	T9271	nummod	I,type
R6078	T9274	T9272	punct	", ",collagen
R6079	T9275	T9272	conj	runx2,collagen
R6080	T9276	T9275	punct	", ",runx2
R6081	T9277	T9275	cc	and,runx2
R6082	T9278	T9279	compound	osterix,genes
R6083	T9279	T9275	conj	genes,runx2
R6084	T9280	T9257	prep	at,express
R6085	T9281	T9282	preconj	both,wk
R6086	T9282	T9280	pobj	wk,at
R6087	T9283	T9282	nummod	1,wk
R6088	T9284	T9282	cc	and,wk
R6089	T9285	T9286	nummod	3,wks
R6090	T9286	T9282	conj	wks,wk
R6091	T9287	T9282	prep	after,wk
R6092	T9288	T9287	pobj	birth,after
R6093	T9289	T9290	punct	(,7A
R6094	T9290	T9257	parataxis	7A,express
R6095	T9291	T9290	compound	Figure,7A
R6096	T9292	T9293	punct	–,7D
R6097	T9293	T9290	prep	7D,7A
R6098	T9294	T9290	cc	and,7A
R6099	T9295	T9290	conj	7I,7A
R6100	T9296	T9297	punct	–,7L
R6101	T9297	T9295	prep	7L,7I
R6102	T9298	T9290	punct	),7A
R6103	T9299	T9257	punct	.,express
R6104	T9301	T9302	prep	In,found
R6105	T9303	T9304	det	the,absence
R6106	T9304	T9301	pobj	absence,In
R6107	T9305	T9304	prep	of,absence
R6108	T9306	T9305	pobj	BMP2,of
R6109	T9307	T9306	cc	and,BMP2
R6110	T9308	T9306	conj	BMP4,BMP2
R6111	T9309	T9302	punct	", ",found
R6112	T9310	T9302	nsubjpass	cells,found
R6113	T9311	T9312	dep	which,are
R6114	T9312	T9310	relcl	are,cells
R6115	T9313	T9312	acomp	fibroblastic,are
R6116	T9314	T9312	prep	in,are
R6117	T9315	T9314	pobj	appearance,in
R6118	T9316	T9317	punct	(,6H
R6119	T9317	T9310	parataxis	6H,cells
R6120	T9318	T9317	compound	Figure,6H
R6121	T9319	T9317	punct	),6H
R6122	T9320	T9302	auxpass	are,found
R6123	T9321	T9302	oprd	adjacent,found
R6124	T9322	T9321	prep	to,adjacent
R6125	T9323	T9324	det	the,surfaces
R6126	T9324	T9322	pobj	surfaces,to
R6127	T9325	T9324	amod	mineralized,surfaces
R6128	T9326	T9324	compound	cartilage,surfaces
R6129	T9327	T9302	punct	.,found
R6130	T9329	T9330	det	These,cells
R6131	T9330	T9331	nsubj	cells,express
R6132	T9332	T9331	dobj	amounts,express
R6133	T9333	T9332	prep	of,amounts
R6134	T9334	T9335	nmod	type,collagen
R6135	T9335	T9333	pobj	collagen,of
R6136	T9336	T9334	nummod	I,type
R6137	T9337	T9335	cc	and,collagen
R6138	T9338	T9335	conj	runx2,collagen
R6139	T9339	T9332	amod	comparable,amounts
R6140	T9340	T9339	prep	to,comparable
R6141	T9341	T9342	compound	control,osteoblasts
R6142	T9342	T9340	pobj	osteoblasts,to
R6143	T9343	T9331	punct	", ",express
R6144	T9344	T9331	cc	but,express
R6145	T9345	T9346	poss	their,expression
R6146	T9346	T9347	nsubj	expression,becomes
R6147	T9347	T9331	conj	becomes,express
R6148	T9348	T9346	prep	of,expression
R6149	T9349	T9348	pobj	osterix,of
R6150	T9350	T9347	punct	", ",becomes
R6151	T9351	T9352	mark	while,noticeable
R6152	T9352	T9347	advcl	noticeable,becomes
R6153	T9353	T9352	prep	at,noticeable
R6154	T9354	T9355	nummod	1,wk
R6155	T9355	T9353	pobj	wk,at
R6156	T9356	T9347	punct	", ",becomes
R6157	T9357	T9358	advmod	almost,undetectable
R6158	T9358	T9347	acomp	undetectable,becomes
R6159	T9359	T9347	prep	at,becomes
R6160	T9360	T9361	nummod	3,wks
R6161	T9361	T9359	pobj	wks,at
R6162	T9362	T9363	punct	(,7E
R6163	T9363	T9347	parataxis	7E,becomes
R6164	T9364	T9363	compound	Figure,7E
R6165	T9365	T9366	punct	–,7H
R6166	T9366	T9363	prep	7H,7E
R6167	T9367	T9363	cc	and,7E
R6168	T9368	T9363	conj	7M,7E
R6169	T9369	T9370	punct	–,7P
R6170	T9370	T9368	prep	7P,7M
R6171	T9371	T9363	punct	),7E
R6172	T9372	T9347	punct	.,becomes
R6173	T9374	T9375	det	These,results
R6174	T9375	T9376	nsubj	results,allow
R6175	T9377	T9378	nsubj	us,conclude
R6176	T9378	T9376	ccomp	conclude,allow
R6177	T9379	T9378	aux	to,conclude
R6178	T9380	T9381	mark	that,be
R6179	T9381	T9378	ccomp	be,conclude
R6180	T9382	T9383	det	the,cells
R6181	T9383	T9381	nsubj	cells,be
R6182	T9384	T9385	npadvmod	fibroblast,like
R6183	T9385	T9383	amod	like,cells
R6184	T9386	T9385	punct	-,like
R6185	T9387	T9383	amod	resident,cells
R6186	T9388	T9387	prep	in,resident
R6187	T9389	T9390	det	the,shaft
R6188	T9390	T9388	pobj	shaft,in
R6189	T9391	T9390	compound	bone,shaft
R6190	T9392	T9393	punct	(,6H
R6191	T9393	T9383	parataxis	6H,cells
R6192	T9394	T9393	compound	Figure,6H
R6193	T9395	T9393	punct	),6H
R6194	T9396	T9381	aux	may,be
R6195	T9397	T9398	compound	osteoprogenitor,cells
R6196	T9398	T9381	attr	cells,be
R6197	T9399	T9398	amod	unable,cells
R6198	T9400	T9401	aux	to,differentiate
R6199	T9401	T9399	xcomp	differentiate,unable
R6200	T9402	T9401	prep	into,differentiate
R6201	T9403	T9404	amod	mature,osteoblasts
R6202	T9404	T9402	pobj	osteoblasts,into
R6203	T9405	T9401	prep	in,differentiate
R6204	T9406	T9407	det	the,absence
R6205	T9407	T9405	pobj	absence,in
R6206	T9408	T9407	prep	of,absence
R6207	T9409	T9408	pobj	BMP2,of
R6208	T9410	T9409	cc	and,BMP2
R6209	T9411	T9409	conj	BMP4,BMP2
R6210	T9412	T9376	punct	.,allow

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T8220	0-12	GO:0001503	denotes	Osteogenesis
T8221	38-42	PR_EXT:000000164	denotes	BMP2
T8222	44-48	PR_EXT:000000165	denotes	BMP4
T8223	59-68	UBERON:0004347	denotes	Limb Buds
T8224	69-73	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T8225	69-83	GO_EXT:bone_development_or_ossification	denotes	Bone formation
T8226	131-156	CL:0000743	denotes	hypertrophic chondrocytes
T8227	177-190	UBERON:0002222	denotes	perichondrium
T8228	219-223	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8229	256-268	GO:0001503	denotes	osteogenesis
T8230	297-301	PR_EXT:000000164	denotes	BMP2
T8231	303-307	PR_EXT:000000165	denotes	BMP4
T8232	318-323	UBERON:0002101	denotes	limbs
T8233	355-364	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T8234	435-440	CL_GO_EXT:cell	denotes	cells
T8235	444-448	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8236	496-500	PR_EXT:000000164	denotes	BMP2
T8237	505-509	PR_EXT:000000165	denotes	BMP4
T8238	593-600	UBERON:0000976	denotes	humerus
T8239	606-611	CL_GO_EXT:cell	denotes	cells
T8240	640-646	GO:0031012	denotes	matrix
T8241	647-654	GO:0010467	denotes	express
T8242	659-669	CL:0000062	denotes	osteoblast
T8243	670-676	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T8244	677-680	CHEBI_PR_EXT:collagen	denotes	Col
T8245	677-682	PR_EXT:000003263	denotes	Col I
T8246	727-748	UBERON:4000088	denotes	mineralized cartilage
T8247	772-792	_FRAGMENT	denotes	hypertrophic zone of
T8248	797-809	UBERON:0006772	denotes	growth plate
T8249	797-803	GO_EXT:biological_growth_entity_or_process	denotes	growth
T8250	840-851	CL:0000092	denotes	osteoclasts
T8251	878-883	CL_GO_EXT:cell	denotes	cells
T8252	930-948	UBERON:0002484	denotes	bone marrow cavity
T8253	1001-1022	CL:0007010	denotes	Osteoprogenitor cells
T8254	1017-1022	CL_GO_EXT:cell	denotes	cells
T8255	1028-1032	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8256	1082-1089	UBERON:0008883	denotes	osteoid
T8257	1103-1118	UBERON:0002483	denotes	trabecular bone
T8258	1126-1144	UBERON:0002484	denotes	bone marrow cavity
T8259	1172-1185	UBERON:0001439	denotes	cortical bone
T8260	1189-1194	GO:0007567	denotes	birth
T8261	1240-1245	UBERON:0002101	denotes	limbs
T8262	1259-1263	PR_EXT:000000164	denotes	BMP2
T8263	1268-1272	PR_EXT:000000165	denotes	BMP4
T8264	1314-1326	UBERON:0010363	denotes	endochondral
T8265	1354-1369	GO:0001944	denotes	vascularization
T8266	1380-1384	PR_EXT:000000164	denotes	Bmp2
T8267	1389-1393	PR_EXT:000000165	denotes	Bmp4
T8268	1398-1402	PR_EXT:000013316	denotes	Prx1
T8269	1408-1417	UBERON:0002102	denotes	forelimbs
T8270	1423-1434	CL:0000092	denotes	osteoclasts
T8271	1439-1448	GO_EXT:biological_recruitment	denotes	recruited
T8272	1456-1477	UBERON:4000088	denotes	mineralized cartilage
T8273	1549-1567	UBERON:0002484	denotes	bone marrow cavity
T8274	1596-1600	PR_EXT:000000164	denotes	BMP2
T8275	1605-1609	PR_EXT:000000165	denotes	BMP4
T8276	1620-1631	UBERON:0002371	denotes	bone marrow
T8277	1620-1641	GO:0048539	denotes	bone marrow formation
T8278	1646-1661	UBERON:0002483	denotes	trabecular bone
T8279	1657-1671	GO_EXT:bone_development_or_ossification	denotes	bone formation
T8280	1696-1701	GO:0007567	denotes	birth
T8281	1720-1724	PR_EXT:000000164	denotes	BMP2
T8282	1729-1733	PR_EXT:000000165	denotes	BMP4
T8283	1769-1773	PR_EXT:000000164	denotes	Bmp2
T8284	1778-1782	PR_EXT:000000165	denotes	Bmp4
T8285	1787-1791	PR_EXT:000013316	denotes	Prx1
T8286	1797-1802	UBERON:0001474	denotes	bones
T8287	1806-1811	GO:0007567	denotes	birth
T8288	1839-1846	UBERON:0000922	denotes	embryos
T8289	1912-1916	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8290	1912-1926	GO_EXT:bone_development_or_ossification	denotes	bone formation
T8291	1945-1949	PR_EXT:000000164	denotes	BMP2
T8292	1954-1958	PR_EXT:000000165	denotes	BMP4
T8293	1985-1989	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8294	2004-2008	PR_EXT:000000034	denotes	BMPs
T8295	2048-2052	PR_EXT:000000164	denotes	Bmp2
T8296	2057-2061	PR_EXT:000000165	denotes	Bmp4
T8297	2066-2070	PR_EXT:000013316	denotes	Prx1
T8298	2076-2080	NCBITaxon:10088	denotes	mice
T8299	2150-2154	NCBITaxon:10088	denotes	mice
T8300	2158-2162	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8301	2208-2233	CL:0000743	denotes	hypertrophic chondrocytes
T8302	2267-2278	CL:0000062	denotes	osteoblasts
T8303	2301-2314	UBERON:0001439	denotes	cortical bone
T8304	2322-2339	UBERON:0004769	denotes	diaphyseal region
T8305	2384-2413	UBERON:0010357	denotes	secondary ossification center
T8306	2394-2406	GO:0001503	denotes	ossification
T8307	2481-2510	UBERON:0010357	denotes	secondary ossification center
T8308	2491-2503	GO:0001503	denotes	ossification
T8309	2564-2575	UBERON:0002371	denotes	bone marrow
T8310	2564-2585	GO:0048539	denotes	bone marrow formation
T8311	2620-2635	UBERON:0002483	denotes	trabecular bone
T8312	2658-2664	UBERON:0000479	denotes	tissue
T8313	2706-2710	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8314	2706-2720	GO_EXT:bone_development_or_ossification	denotes	bone formation
T8315	2755-2759	PR_EXT:000000164	denotes	BMP2
T8316	2764-2768	PR_EXT:000000165	denotes	BMP4
T8317	2789-2794	GO:0007567	denotes	birth
T8318	2833-2850	UBERON:0004765	denotes	skeletal elements
T8319	2865-2872	SO_EXT:sequence_altered_entity	denotes	mutants
T8320	2917-2926	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T8321	2927-2932	UBERON:0002101	denotes	limbs
T8322	2970-2974	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8323	2989-3019	UBERON:0008187	denotes	site of hypertrophic cartilage
T8324	3036-3054	UBERON:0002484	denotes	bone marrow cavity
T8325	3056-3071	UBERON:0002483	denotes	trabecular bone
T8326	3076-3089	UBERON:0001439	denotes	cortical bone
T8327	3119-3130	CL:0000092	denotes	osteoclasts
T8328	3141-3150	GO_EXT:biological_recruitment	denotes	recruited
T8329	3168-3189	UBERON:4000088	denotes	mineralized cartilage
T8330	3222-3228	UBERON:0000479	denotes	tissue
T8331	3283-3304	UBERON:4000088	denotes	mineralized cartilage
T8332	3312-3329	UBERON:0004769	denotes	diaphyseal region
T8333	3357-3361	UBERON:0000464	denotes	void
T8334	3368-3372	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8335	3368-3382	GO_EXT:bone_development_or_ossification	denotes	bone formation
T8336	3450-3454	UBERON:0000464	denotes	void
T8337	3485-3492	UBERON:0000479	denotes	tissues
T8338	3510-3516	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T8339	3531-3532	UBERON_EXT:muscle_structure_or_tissue	denotes	m
T8340	3567-3585	GO:0045453	denotes	resorption of bone
T8341	3581-3585	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8342	3637-3642	UBERON:0000981	denotes	femur
T8343	3646-3652	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8344	3653-3660	NCBITaxon:33208	denotes	animals
T8345	3685-3689	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8346	3753-3763	CL:0000062	denotes	osteoblast
T8347	3764-3779	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8348	3787-3791	PR_EXT:000000164	denotes	Bmp2
T8349	3796-3800	PR_EXT:000000165	denotes	Bmp4
T8350	3805-3809	PR_EXT:000013316	denotes	Prx1
T8351	3815-3819	NCBITaxon:10088	denotes	mice
T8352	3852-3856	UBERON:0002101	denotes	limb
T8353	7058-7068	CL:0000062	denotes	osteoblast
T8354	7069-7084	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T8355	7095-7099	PR_EXT:000000164	denotes	Bmp2
T8356	7104-7108	PR_EXT:000000165	denotes	Bmp4
T8357	7113-7117	PR_EXT:000013316	denotes	Prx1
T8358	7123-7132	UBERON:0002102	denotes	forelimbs
T8359	7146-7156	CL:0000062	denotes	osteoblast
T8360	7165-7169	SO_EXT:0000704	denotes	gene
T8361	7165-7180	GO:0010467	denotes	gene expression
T8362	7208-7212	NCBITaxon:10088	denotes	mice
T8363	7214-7225	CL:0000062	denotes	osteoblasts
T8364	7248-7258	_FRAGMENT	denotes	trabecular
T8365	7272-7276	UBERON:0002483	denotes	bone
T8366	7263-7276	UBERON:0001439	denotes	cortical bone
T8367	7277-7284	GO:0010467	denotes	express
T8368	7285-7300	PR_EXT:000003263	denotes	type I collagen
T8369	7292-7300	CHEBI_PR_EXT:collagen	denotes	collagen
T8370	7302-7307	PR_EXT:000014364	denotes	runx2
T8371	7313-7320	PR_EXT:000015445	denotes	osterix
T8372	7321-7326	SO_EXT:0000704	denotes	genes
T8373	7356-7361	GO:0007567	denotes	birth
T8374	7406-7410	PR_EXT:000000164	denotes	BMP2
T8375	7415-7419	PR_EXT:000000165	denotes	BMP4
T8376	7421-7426	CL_GO_EXT:cell	denotes	cells
T8377	7437-7449	CL:0000057	denotes	fibroblastic
T8378	7502-7523	UBERON:4000088	denotes	mineralized cartilage
T8379	7540-7545	CL_GO_EXT:cell	denotes	cells
T8380	7546-7553	GO:0010467	denotes	express
T8381	7565-7580	PR_EXT:000003263	denotes	type I collagen
T8382	7572-7580	CHEBI_PR_EXT:collagen	denotes	collagen
T8383	7585-7590	PR_EXT:000014364	denotes	runx2
T8384	7613-7624	CL:0000062	denotes	osteoblasts
T8385	7636-7646	GO:0010467	denotes	expression
T8386	7650-7657	PR_EXT:000015445	denotes	osterix
T8387	7792-7802	CL:0000057	denotes	fibroblast
T8388	7808-7813	CL_GO_EXT:cell	denotes	cells
T8389	7830-7840	UBERON:0004769	denotes	bone shaft
T8390	7860-7881	CL:0007010	denotes	osteoprogenitor cells
T8391	7876-7881	CL_GO_EXT:cell	denotes	cells
T8392	7892-7905	GO_RO_EXT:developmental_differentiation_process	denotes	differentiate
T8393	7918-7929	CL:0000062	denotes	osteoblasts
T8394	7948-7952	PR_EXT:000000164	denotes	BMP2
T8395	7957-7961	PR_EXT:000000165	denotes	BMP4
R5241	T8248	T8247	_lexicallyChainedTo	growth plate,hypertrophic zone of
R5242	T8365	T8364	_lexicallyChainedTo	bone,trabecular

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T8085	0-12	GO:0001503	denotes	Osteogenesis
T8086	38-42	PR:000000164	denotes	BMP2
T8087	44-48	PR:000000165	denotes	BMP4
T8088	59-68	UBERON:0004347	denotes	Limb Buds
T8089	131-156	CL:0000743	denotes	hypertrophic chondrocytes
T8090	177-190	UBERON:0002222	denotes	perichondrium
T8091	256-268	GO:0001503	denotes	osteogenesis
T8092	297-301	PR:000000164	denotes	BMP2
T8093	303-307	PR:000000165	denotes	BMP4
T8094	318-323	UBERON:0002101	denotes	limbs
T8095	496-500	PR:000000164	denotes	BMP2
T8096	505-509	PR:000000165	denotes	BMP4
T8097	593-600	UBERON:0000976	denotes	humerus
T8098	640-646	GO:0031012	denotes	matrix
T8099	647-654	GO:0010467	denotes	express
T8100	659-669	CL:0000062	denotes	osteoblast
T8101	677-682	PR:000003263	denotes	Col I
T8102	727-748	UBERON:4000088	denotes	mineralized cartilage
T8103	772-792	_FRAGMENT	denotes	hypertrophic zone of
T8104	797-809	UBERON:0006772	denotes	growth plate
T8105	840-851	CL:0000092	denotes	osteoclasts
T8106	930-948	UBERON:0002484	denotes	bone marrow cavity
T8107	1001-1022	CL:0007010	denotes	Osteoprogenitor cells
T8108	1082-1089	UBERON:0008883	denotes	osteoid
T8109	1103-1118	UBERON:0002483	denotes	trabecular bone
T8110	1126-1144	UBERON:0002484	denotes	bone marrow cavity
T8111	1172-1185	UBERON:0001439	denotes	cortical bone
T8112	1189-1194	GO:0007567	denotes	birth
T8113	1240-1245	UBERON:0002101	denotes	limbs
T8114	1259-1263	PR:000000164	denotes	BMP2
T8115	1268-1272	PR:000000165	denotes	BMP4
T8116	1314-1326	UBERON:0010363	denotes	endochondral
T8117	1354-1369	GO:0001944	denotes	vascularization
T8118	1380-1384	PR:000000164	denotes	Bmp2
T8119	1389-1393	PR:000000165	denotes	Bmp4
T8120	1398-1402	PR:000013316	denotes	Prx1
T8121	1408-1417	UBERON:0002102	denotes	forelimbs
T8122	1423-1434	CL:0000092	denotes	osteoclasts
T8123	1456-1477	UBERON:4000088	denotes	mineralized cartilage
T8124	1549-1567	UBERON:0002484	denotes	bone marrow cavity
T8125	1596-1600	PR:000000164	denotes	BMP2
T8126	1605-1609	PR:000000165	denotes	BMP4
T8127	1620-1631	UBERON:0002371	denotes	bone marrow
T8128	1620-1641	GO:0048539	denotes	bone marrow formation
T8129	1646-1661	UBERON:0002483	denotes	trabecular bone
T8130	1696-1701	GO:0007567	denotes	birth
T8131	1720-1724	PR:000000164	denotes	BMP2
T8132	1729-1733	PR:000000165	denotes	BMP4
T8133	1769-1773	PR:000000164	denotes	Bmp2
T8134	1778-1782	PR:000000165	denotes	Bmp4
T8135	1787-1791	PR:000013316	denotes	Prx1
T8136	1797-1802	UBERON:0001474	denotes	bones
T8137	1806-1811	GO:0007567	denotes	birth
T8138	1839-1846	UBERON:0000922	denotes	embryos
T8139	1945-1949	PR:000000164	denotes	BMP2
T8140	1954-1958	PR:000000165	denotes	BMP4
T8141	2004-2008	PR:000000034	denotes	BMPs
T8142	2048-2052	PR:000000164	denotes	Bmp2
T8143	2057-2061	PR:000000165	denotes	Bmp4
T8144	2066-2070	PR:000013316	denotes	Prx1
T8145	2076-2080	NCBITaxon:10088	denotes	mice
T8146	2150-2154	NCBITaxon:10088	denotes	mice
T8147	2208-2233	CL:0000743	denotes	hypertrophic chondrocytes
T8148	2267-2278	CL:0000062	denotes	osteoblasts
T8149	2301-2314	UBERON:0001439	denotes	cortical bone
T8150	2322-2339	UBERON:0004769	denotes	diaphyseal region
T8151	2384-2413	UBERON:0010357	denotes	secondary ossification center
T8152	2394-2406	GO:0001503	denotes	ossification
T8153	2481-2510	UBERON:0010357	denotes	secondary ossification center
T8154	2491-2503	GO:0001503	denotes	ossification
T8155	2564-2575	UBERON:0002371	denotes	bone marrow
T8156	2564-2585	GO:0048539	denotes	bone marrow formation
T8157	2620-2635	UBERON:0002483	denotes	trabecular bone
T8158	2658-2664	UBERON:0000479	denotes	tissue
T8159	2755-2759	PR:000000164	denotes	BMP2
T8160	2764-2768	PR:000000165	denotes	BMP4
T8161	2789-2794	GO:0007567	denotes	birth
T8162	2833-2850	UBERON:0004765	denotes	skeletal elements
T8163	2927-2932	UBERON:0002101	denotes	limbs
T8164	2989-3019	UBERON:0008187	denotes	site of hypertrophic cartilage
T8165	3036-3054	UBERON:0002484	denotes	bone marrow cavity
T8166	3056-3071	UBERON:0002483	denotes	trabecular bone
T8167	3076-3089	UBERON:0001439	denotes	cortical bone
T8168	3119-3130	CL:0000092	denotes	osteoclasts
T8169	3168-3189	UBERON:4000088	denotes	mineralized cartilage
T8170	3222-3228	UBERON:0000479	denotes	tissue
T8171	3283-3304	UBERON:4000088	denotes	mineralized cartilage
T8172	3312-3329	UBERON:0004769	denotes	diaphyseal region
T8173	3357-3361	UBERON:0000464	denotes	void
T8174	3450-3454	UBERON:0000464	denotes	void
T8175	3485-3492	UBERON:0000479	denotes	tissues
T8176	3567-3585	GO:0045453	denotes	resorption of bone
T8177	3637-3642	UBERON:0000981	denotes	femur
T8178	3653-3660	NCBITaxon:33208	denotes	animals
T8179	3753-3763	CL:0000062	denotes	osteoblast
T8180	3787-3791	PR:000000164	denotes	Bmp2
T8181	3796-3800	PR:000000165	denotes	Bmp4
T8182	3805-3809	PR:000013316	denotes	Prx1
T8183	3815-3819	NCBITaxon:10088	denotes	mice
T8184	3852-3856	UBERON:0002101	denotes	limb
T8185	7058-7068	CL:0000062	denotes	osteoblast
T8186	7095-7099	PR:000000164	denotes	Bmp2
T8187	7104-7108	PR:000000165	denotes	Bmp4
T8188	7113-7117	PR:000013316	denotes	Prx1
T8189	7123-7132	UBERON:0002102	denotes	forelimbs
T8190	7146-7156	CL:0000062	denotes	osteoblast
T8191	7165-7169	SO:0000704	denotes	gene
T8192	7165-7180	GO:0010467	denotes	gene expression
T8193	7208-7212	NCBITaxon:10088	denotes	mice
T8194	7214-7225	CL:0000062	denotes	osteoblasts
T8195	7248-7258	_FRAGMENT	denotes	trabecular
T8196	7272-7276	UBERON:0002483	denotes	bone
T8197	7263-7276	UBERON:0001439	denotes	cortical bone
T8198	7277-7284	GO:0010467	denotes	express
T8199	7285-7300	PR:000003263	denotes	type I collagen
T8200	7302-7307	PR:000014364	denotes	runx2
T8201	7313-7320	PR:000015445	denotes	osterix
T8202	7321-7326	SO:0000704	denotes	genes
T8203	7356-7361	GO:0007567	denotes	birth
T8204	7406-7410	PR:000000164	denotes	BMP2
T8205	7415-7419	PR:000000165	denotes	BMP4
T8206	7437-7449	CL:0000057	denotes	fibroblastic
T8207	7502-7523	UBERON:4000088	denotes	mineralized cartilage
T8208	7546-7553	GO:0010467	denotes	express
T8209	7565-7580	PR:000003263	denotes	type I collagen
T8210	7585-7590	PR:000014364	denotes	runx2
T8211	7613-7624	CL:0000062	denotes	osteoblasts
T8212	7636-7646	GO:0010467	denotes	expression
T8213	7650-7657	PR:000015445	denotes	osterix
T8214	7792-7802	CL:0000057	denotes	fibroblast
T8215	7830-7840	UBERON:0004769	denotes	bone shaft
T8216	7860-7881	CL:0007010	denotes	osteoprogenitor cells
T8217	7918-7929	CL:0000062	denotes	osteoblasts
T8218	7948-7952	PR:000000164	denotes	BMP2
T8219	7957-7961	PR:000000165	denotes	BMP4
R5239	T8104	T8103	_lexicallyChainedTo	growth plate,hypertrophic zone of
R5240	T8196	T8195	_lexicallyChainedTo	bone,trabecular

PMC:1713256 / 33453-41906 JSONTXT

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PMC:1713256 / 33453-41906 JSON TXT