PMC:1687185 / 28780-29525 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1687185","sourcedb":"PMC","sourceid":"1687185","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1687185","text":"Our program was implemented on Red Hat Linux version 9 and runs on a Pentium IV 2.8 GHz machine. The core algorithm that we have implemented is XP_EM described in Algorithm 1. XP_EM obtains the initial alignments and the original data sequences along with the length of the motif. It returns the best motif that is obtained in the neighboring region of the sequences. This procedure constructs the PSSM, performs EM refinement, and then computes the Tier-1 and Tier-2 solutions by calling the procedure Next_Tier. The eigenvectors of the Hessian were computed using the source code obtained from [23]. Next_Tier takes a PSSM as an input and computes an array of PSSMs corresponding to the next tier local maxima using the exit point methodology.","tracks":[]}