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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1647278","sourcedb":"PMC","sourceid":"1647278","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1647278","text":"When π is known (and hence μ), several statistical methods are available to compute S: exact computations [1-4], Gaussian [5,6], binomial [7,8], compound Poisson [9-11] or large deviations approximations [12]. But in general, the parameter π is not available and must be estimated. Let us denote by N0 (resp. N1) the (overlap) frequencies of all words of size m (resp. m + 1) in the sequence Y = Y1 ... Yn, then the Maximum-Likelihood Estimator (MLE) of π is given by","tracks":[{"project":"2_test","denotations":[{"id":"17044916-16722531-1696306","span":{"begin":107,"end":108},"obj":"16722531"},{"id":"17044916-9719638-1696307","span":{"begin":139,"end":140},"obj":"9719638"},{"id":"17044916-15840704-1696308","span":{"begin":141,"end":142},"obj":"15840704"},{"id":"17044916-15662195-1696309","span":{"begin":205,"end":207},"obj":"15662195"}],"attributes":[{"subj":"17044916-16722531-1696306","pred":"source","obj":"2_test"},{"subj":"17044916-9719638-1696307","pred":"source","obj":"2_test"},{"subj":"17044916-15840704-1696308","pred":"source","obj":"2_test"},{"subj":"17044916-15662195-1696309","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ece393","default":true}]}]}}