PMC:1635039 / 606-1141
Annnotations
craft-sa-dev
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deleted the TGF-β type I receptor Alk5 specifically in the mouse neural crest cell lineage. Failure in signaling via ALK5 leads to severe cardiovascular and pharyngeal defects, including inappropriate remodeling of pharyngeal arch arteries, abnormal aortic sac development, failure in pharyngeal organ migration and persistent truncus arteriosus. While ALK5 is not required for neural crest cell migration, our results demonstrate that it plays an important role in the survival of post-migratory cardiac neural crest cells."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T477","span":{"begin":11,"end":18},"obj":"SO_EXT:sequence_deletion_process"},{"id":"T478","span":{"begin":23,"end":44},"obj":"GO_PR_EXT:transforming_growth_factor_beta_receptor_type_I"},{"id":"T479","span":{"begin":45,"end":49},"obj":"PR_EXT:000000047"},{"id":"T480","span":{"begin":70,"end":75},"obj":"NCBITaxon:10088"},{"id":"T481","span":{"begin":76,"end":88},"obj":"UBERON:0002342"},{"id":"T482","span":{"begin":76,"end":93},"obj":"CL_EXT:neural_crest_cell"},{"id":"T483","span":{"begin":89,"end":93},"obj":"CL_GO_EXT:cell"},{"id":"T484","span":{"begin":114,"end":123},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T485","span":{"begin":128,"end":132},"obj":"PR_EXT:000000047"},{"id":"T486","span":{"begin":149,"end":163},"obj":"UBERON:0004535"},{"id":"T487","span":{"begin":168,"end":178},"obj":"UBERON:0006562"},{"id":"T488","span":{"begin":226,"end":250},"obj":"UBERON:0004363"},{"id":"T489","span":{"begin":261,"end":271},"obj":"UBERON:0005432"},{"id":"T490","span":{"begin":296,"end":306},"obj":"UBERON:0006562"},{"id":"T491","span":{"begin":307,"end":312},"obj":"UBERON:0000062"},{"id":"T492","span":{"begin":313,"end":322},"obj":"GO_EXT:biological_movement_or_translocation_process"},{"id":"T493","span":{"begin":338,"end":356},"obj":"UBERON:0002061"},{"id":"T494","span":{"begin":364,"end":368},"obj":"PR_EXT:000000047"},{"id":"T495","span":{"begin":389,"end":401},"obj":"UBERON:0002342"},{"id":"T496","span":{"begin":389,"end":406},"obj":"CL_EXT:neural_crest_cell"},{"id":"T497","span":{"begin":389,"end":416},"obj":"GO:0001755"},{"id":"T498","span":{"begin":402,"end":406},"obj":"CL_GO_EXT:cell"},{"id":"T499","span":{"begin":498,"end":507},"obj":"GO_EXT:biological_movement_or_translocation_process"},{"id":"T500","span":{"begin":508,"end":528},"obj":"UBERON:0000095"},{"id":"T501","span":{"begin":516,"end":534},"obj":"CL_EXT:neural_crest_cell"},{"id":"T502","span":{"begin":529,"end":534},"obj":"CL_GO_EXT:cell"}],"text":"Results\nWe deleted the TGF-β type I receptor Alk5 specifically in the mouse neural crest cell lineage. Failure in signaling via ALK5 leads to severe cardiovascular and pharyngeal defects, including inappropriate remodeling of pharyngeal arch arteries, abnormal aortic sac development, failure in pharyngeal organ migration and persistent truncus arteriosus. While ALK5 is not required for neural crest cell migration, our results demonstrate that it plays an important role in the survival of post-migratory cardiac neural crest cells."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T423","span":{"begin":23,"end":28},"obj":"PR:000000046"},{"id":"T424","span":{"begin":45,"end":49},"obj":"PR:000000047"},{"id":"T425","span":{"begin":70,"end":75},"obj":"NCBITaxon:10088"},{"id":"T426","span":{"begin":76,"end":88},"obj":"UBERON:0002342"},{"id":"T427","span":{"begin":128,"end":132},"obj":"PR:000000047"},{"id":"T428","span":{"begin":149,"end":163},"obj":"UBERON:0004535"},{"id":"T429","span":{"begin":168,"end":178},"obj":"UBERON:0006562"},{"id":"T430","span":{"begin":226,"end":250},"obj":"UBERON:0004363"},{"id":"T431","span":{"begin":261,"end":271},"obj":"UBERON:0005432"},{"id":"T432","span":{"begin":296,"end":306},"obj":"UBERON:0006562"},{"id":"T433","span":{"begin":307,"end":312},"obj":"UBERON:0000062"},{"id":"T434","span":{"begin":338,"end":356},"obj":"UBERON:0002061"},{"id":"T435","span":{"begin":364,"end":368},"obj":"PR:000000047"},{"id":"T436","span":{"begin":389,"end":401},"obj":"UBERON:0002342"},{"id":"T437","span":{"begin":389,"end":416},"obj":"GO:0001755"},{"id":"T438","span":{"begin":508,"end":528},"obj":"UBERON:0000095"}],"text":"Results\nWe deleted the TGF-β type I receptor Alk5 specifically in the mouse neural crest cell lineage. Failure in signaling via ALK5 leads to severe cardiovascular and pharyngeal defects, including inappropriate remodeling of pharyngeal arch arteries, abnormal aortic sac development, failure in pharyngeal organ migration and persistent truncus arteriosus. While ALK5 is not required for neural crest cell migration, our results demonstrate that it plays an important role in the survival of post-migratory cardiac neural crest cells."}