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PMC:1635039 / 3499-5886 JSONTXT

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Id Subject Object Predicate Lexical cue
T3121 0-3 NN denotes TGF
T3122 4-5 NN denotes β
T3123 3-4 HYPH denotes -
T3124 16-23 NNS denotes ligands
T3125 6-15 NN denotes subfamily
T3126 24-30 VBP denotes signal
T3127 31-34 IN denotes via
T3128 35-36 DT denotes a
T3129 46-53 NN denotes complex
T3130 37-45 NN denotes receptor
T3131 54-62 VBN denotes composed
T3132 63-65 IN denotes of
T3133 66-69 CD denotes two
T3134 78-87 NNS denotes receptors
T3135 70-74 NN denotes type
T3136 75-77 CD denotes II
T3137 88-91 CC denotes and
T3138 92-95 CD denotes two
T3139 103-112 NNS denotes receptors
T3140 96-100 NN denotes type
T3141 101-102 CD denotes I
T3142 113-114 -LRB- denotes [
T3143 117-119 CD denotes 15
T3144 114-116 CD denotes 14
T3145 116-117 , denotes ,
T3146 119-120 -RRB- denotes ]
T3147 120-121 . denotes .
T3148 121-303 sentence denotes Ligand binding leads to phosphorylation and activation of type I receptors, which, in turn, phosphorylate and activate a specific set of downstream signaling molecules called Smads.
T3149 122-128 NN denotes Ligand
T3150 129-136 NN denotes binding
T3151 137-142 VBZ denotes leads
T3152 143-145 IN denotes to
T3153 146-161 NN denotes phosphorylation
T3154 162-165 CC denotes and
T3155 166-176 NN denotes activation
T3156 177-179 IN denotes of
T3157 180-184 NN denotes type
T3158 187-196 NNS denotes receptors
T3159 185-186 CD denotes I
T3160 196-198 , denotes ,
T3161 198-203 WDT denotes which
T3162 214-227 VBP denotes phosphorylate
T3163 203-205 , denotes ,
T3164 205-207 IN denotes in
T3165 208-212 NN denotes turn
T3166 212-214 , denotes ,
T3167 228-231 CC denotes and
T3168 232-240 VBP denotes activate
T3169 241-242 DT denotes a
T3170 252-255 NN denotes set
T3171 243-251 JJ denotes specific
T3172 256-258 IN denotes of
T3173 259-269 JJ denotes downstream
T3174 280-289 NNS denotes molecules
T3175 270-279 NN denotes signaling
T3176 290-296 VBN denotes called
T3177 297-302 NNS denotes Smads
T3178 302-303 . denotes .
T3179 303-556 sentence denotes In general terms, TGF-βs bind to the TGF-β type II receptor (TGFβRII) and TGF-β type I receptor (ALK5) activating TGF-β Smads (2 and 3), while BMPs bind to the BMP type II receptor and type I receptors ALK2, -3, or 6, activating BMP Smads (1, 5 and 8).
T3180 304-306 IN denotes In
T3181 329-333 VBP denotes bind
T3182 307-314 JJ denotes general
T3183 315-320 NNS denotes terms
T3184 320-322 , denotes ,
T3185 322-325 NN denotes TGF
T3186 326-328 NNS denotes βs
T3187 325-326 HYPH denotes -
T3188 334-336 IN denotes to
T3189 337-340 DT denotes the
T3190 355-363 NN denotes receptor
T3191 341-344 NN denotes TGF
T3192 345-346 NN denotes β
T3193 344-345 HYPH denotes -
T3194 347-351 NN denotes type
T3195 352-354 CD denotes II
T3196 364-365 -LRB- denotes (
T3197 365-372 NN denotes TGFβRII
T3198 372-373 -RRB- denotes )
T3199 374-377 CC denotes and
T3200 378-381 NN denotes TGF
T3201 382-383 NN denotes β
T3202 381-382 HYPH denotes -
T3203 391-399 NN denotes receptor
T3204 384-388 NN denotes type
T3205 389-390 CD denotes I
T3206 400-401 -LRB- denotes (
T3207 401-405 NN denotes ALK5
T3208 405-406 -RRB- denotes )
T3209 407-417 VBG denotes activating
T3210 418-421 NN denotes TGF
T3211 422-423 NN denotes β
T3212 421-422 HYPH denotes -
T3213 424-429 NNS denotes Smads
T3214 430-431 -LRB- denotes (
T3215 431-432 CD denotes 2
T3216 433-436 CC denotes and
T3217 437-438 CD denotes 3
T3218 438-439 -RRB- denotes )
T3219 439-441 , denotes ,
T3220 441-446 IN denotes while
T3221 452-456 VBP denotes bind
T3222 447-451 NNS denotes BMPs
T3223 457-459 IN denotes to
T3224 460-463 DT denotes the
T3225 506-510 NN denotes ALK2
T3226 464-467 NN denotes BMP
T3227 468-472 NN denotes type
T3228 476-484 NN denotes receptor
T3229 473-475 CD denotes II
T3230 485-488 CC denotes and
T3231 489-493 NN denotes type
T3232 496-505 NNS denotes receptors
T3233 494-495 CD denotes I
T3234 510-512 , denotes ,
T3235 512-513 SYM denotes -
T3236 513-514 CD denotes 3
T3237 514-516 , denotes ,
T3238 516-518 CC denotes or
T3239 519-520 CD denotes 6
T3240 520-522 , denotes ,
T3241 522-532 VBG denotes activating
T3242 533-536 NN denotes BMP
T3243 537-542 NNS denotes Smads
T3244 543-544 -LRB- denotes (
T3245 544-545 CD denotes 1
T3246 545-547 , denotes ,
T3247 547-548 CD denotes 5
T3248 549-552 CC denotes and
T3249 553-554 CD denotes 8
T3250 554-555 -RRB- denotes )
T3251 555-556 . denotes .
T3252 556-753 sentence denotes However, it is likely that these signaling interactions are more complex in vivo, possibly allowing formation of heterotetrameric complexes composed of different type II and type I receptors [16].
T3253 557-564 RB denotes However
T3254 569-571 VBZ denotes is
T3255 564-566 , denotes ,
T3256 566-568 PRP denotes it
T3257 572-578 JJ denotes likely
T3258 579-583 IN denotes that
T3259 613-616 VBP denotes are
T3260 584-589 DT denotes these
T3261 600-612 NNS denotes interactions
T3262 590-599 NN denotes signaling
T3263 617-621 RBR denotes more
T3264 622-629 JJ denotes complex
T3265 630-632 FW denotes in
T3266 633-637 FW denotes vivo
T3267 637-639 , denotes ,
T3268 639-647 RB denotes possibly
T3269 648-656 VBG denotes allowing
T3270 657-666 NN denotes formation
T3271 667-669 IN denotes of
T3272 670-686 JJ denotes heterotetrameric
T3273 687-696 NNS denotes complexes
T3274 697-705 VBN denotes composed
T3275 706-708 IN denotes of
T3276 709-718 JJ denotes different
T3277 738-747 NNS denotes receptors
T3278 719-723 NN denotes type
T3279 724-726 CD denotes II
T3280 727-730 CC denotes and
T3281 731-735 NN denotes type
T3282 736-737 CD denotes I
T3283 748-749 -LRB- denotes [
T3284 749-751 CD denotes 16
T3285 751-752 -RRB- denotes ]
T3286 752-753 . denotes .
T3287 753-888 sentence denotes In addition, recent studies have identified novel TGF-β-related ligands, which can bind to entire different combinations of receptors.
T3288 754-756 IN denotes In
T3289 787-797 VBN denotes identified
T3290 757-765 NN denotes addition
T3291 765-767 , denotes ,
T3292 767-773 JJ denotes recent
T3293 774-781 NNS denotes studies
T3294 782-786 VBP denotes have
T3295 798-803 JJ denotes novel
T3296 818-825 NNS denotes ligands
T3297 804-807 NN denotes TGF
T3298 808-809 NN denotes β
T3299 807-808 HYPH denotes -
T3300 810-817 VBN denotes related
T3301 809-810 HYPH denotes -
T3302 825-827 , denotes ,
T3303 827-832 WDT denotes which
T3304 837-841 VB denotes bind
T3305 833-836 MD denotes can
T3306 842-844 IN denotes to
T3307 845-851 JJ denotes entire
T3308 862-874 NNS denotes combinations
T3309 852-861 JJ denotes different
T3310 875-877 IN denotes of
T3311 878-887 NNS denotes receptors
T3312 887-888 . denotes .
T3313 888-1031 sentence denotes For instance, growth and differentiation factors (GDFs) 8 and 9 can bind to Activin type II receptor and ALK5 to activate TGF-β Smads [17,18].
T3314 889-892 IN denotes For
T3315 957-961 VB denotes bind
T3316 893-901 NN denotes instance
T3317 901-903 , denotes ,
T3318 903-909 NN denotes growth
T3319 930-937 NNS denotes factors
T3320 910-913 CC denotes and
T3321 914-929 NN denotes differentiation
T3322 938-939 -LRB- denotes (
T3323 939-943 NNS denotes GDFs
T3324 943-944 -RRB- denotes )
T3325 945-946 CD denotes 8
T3326 947-950 CC denotes and
T3327 951-952 CD denotes 9
T3328 953-956 MD denotes can
T3329 962-964 IN denotes to
T3330 965-972 NN denotes Activin
T3331 981-989 NN denotes receptor
T3332 973-977 NN denotes type
T3333 978-980 CD denotes II
T3334 990-993 CC denotes and
T3335 994-998 NN denotes ALK5
T3336 999-1001 TO denotes to
T3337 1002-1010 VB denotes activate
T3338 1011-1014 NN denotes TGF
T3339 1015-1016 NN denotes β
T3340 1014-1015 HYPH denotes -
T3341 1017-1022 NNS denotes Smads
T3342 1023-1024 -LRB- denotes [
T3343 1027-1029 CD denotes 18
T3344 1024-1026 CD denotes 17
T3345 1026-1027 , denotes ,
T3346 1029-1030 -RRB- denotes ]
T3347 1030-1031 . denotes .
T3348 1031-1191 sentence denotes Therefore, we hypothesized that deletion of Alk5 in a specific cell lineage should reveal phenotypes which cannot be seen in comparable mutants lacking Tgfbr2.
T3349 1032-1041 RB denotes Therefore
T3350 1046-1058 VBD denotes hypothesized
T3351 1041-1043 , denotes ,
T3352 1043-1045 PRP denotes we
T3353 1059-1063 IN denotes that
T3354 1115-1121 VB denotes reveal
T3355 1064-1072 NN denotes deletion
T3356 1073-1075 IN denotes of
T3357 1076-1080 NN denotes Alk5
T3358 1081-1083 IN denotes in
T3359 1084-1085 DT denotes a
T3360 1100-1107 NN denotes lineage
T3361 1086-1094 JJ denotes specific
T3362 1095-1099 NN denotes cell
T3363 1108-1114 MD denotes should
T3364 1122-1132 NNS denotes phenotypes
T3365 1133-1138 WDT denotes which
T3366 1149-1153 VBN denotes seen
T3367 1139-1142 MD denotes can
T3368 1142-1145 RB denotes not
T3369 1146-1148 VB denotes be
T3370 1154-1156 IN denotes in
T3371 1157-1167 JJ denotes comparable
T3372 1168-1175 NNS denotes mutants
T3373 1176-1183 VBG denotes lacking
T3374 1184-1190 NN denotes Tgfbr2
T3375 1190-1191 . denotes .
T3376 1191-1454 sentence denotes Indeed, we recently showed that neural crest cell specific Alk5 mutants display a unique spectrum of craniofacial developmental defects, e.g., cleft snout and severe mandibular hypoplasia [19]; these phenotypes were not seen in corresponding Tgfbr2 mutants [20].
T3377 1192-1198 RB denotes Indeed
T3378 1212-1218 VBD denotes showed
T3379 1198-1200 , denotes ,
T3380 1200-1202 PRP denotes we
T3381 1203-1211 RB denotes recently
T3382 1412-1416 VBN denotes seen
T3383 1219-1223 IN denotes that
T3384 1264-1271 VBP denotes display
T3385 1224-1230 JJ denotes neural
T3386 1237-1241 NN denotes cell
T3387 1231-1236 NN denotes crest
T3388 1242-1250 JJ denotes specific
T3389 1256-1263 NNS denotes mutants
T3390 1251-1255 NN denotes Alk5
T3391 1272-1273 DT denotes a
T3392 1281-1289 NN denotes spectrum
T3393 1274-1280 JJ denotes unique
T3394 1290-1292 IN denotes of
T3395 1293-1305 JJ denotes craniofacial
T3396 1320-1327 NNS denotes defects
T3397 1306-1319 JJ denotes developmental
T3398 1327-1329 , denotes ,
T3399 1329-1333 FW denotes e.g.
T3400 1341-1346 NN denotes snout
T3401 1333-1335 , denotes ,
T3402 1335-1340 NN denotes cleft
T3403 1347-1350 CC denotes and
T3404 1351-1357 JJ denotes severe
T3405 1369-1379 NN denotes hypoplasia
T3406 1358-1368 JJ denotes mandibular
T3407 1380-1381 -LRB- denotes [
T3408 1381-1383 CD denotes 19
T3409 1383-1384 -RRB- denotes ]
T3410 1384-1385 : denotes ;
T3411 1386-1391 DT denotes these
T3412 1392-1402 NNS denotes phenotypes
T3413 1403-1407 VBD denotes were
T3414 1408-1411 RB denotes not
T3415 1417-1419 IN denotes in
T3416 1420-1433 VBG denotes corresponding
T3417 1441-1448 NNS denotes mutants
T3418 1434-1440 NN denotes Tgfbr2
T3419 1449-1450 -LRB- denotes [
T3420 1450-1452 CD denotes 20
T3421 1452-1453 -RRB- denotes ]
T3422 1453-1454 . denotes .
T3423 1454-1683 sentence denotes To determine, whether ALK5 would also mediate unique non-redundant signaling events in cardiac neural crest cells, we focused on cardiac and pharyngeal phenotypes of mouse embryos lacking Alk5 specifically in neural crest cells.
T3424 1455-1457 TO denotes To
T3425 1458-1467 VB denotes determine
T3426 1573-1580 VBD denotes focused
T3427 1467-1469 , denotes ,
T3428 1469-1476 IN denotes whether
T3429 1493-1500 VB denotes mediate
T3430 1477-1481 NN denotes ALK5
T3431 1482-1487 MD denotes would
T3432 1488-1492 RB denotes also
T3433 1501-1507 JJ denotes unique
T3434 1532-1538 NNS denotes events
T3435 1508-1521 JJ denotes non-redundant
T3436 1522-1531 NN denotes signaling
T3437 1539-1541 IN denotes in
T3438 1542-1549 JJ denotes cardiac
T3439 1557-1562 NN denotes crest
T3440 1550-1556 JJ denotes neural
T3441 1563-1568 NNS denotes cells
T3442 1568-1570 , denotes ,
T3443 1570-1572 PRP denotes we
T3444 1581-1583 IN denotes on
T3445 1584-1591 JJ denotes cardiac
T3446 1607-1617 NNS denotes phenotypes
T3447 1592-1595 CC denotes and
T3448 1596-1606 JJ denotes pharyngeal
T3449 1618-1620 IN denotes of
T3450 1621-1626 NN denotes mouse
T3451 1627-1634 NNS denotes embryos
T3452 1635-1642 VBG denotes lacking
T3453 1643-1647 NN denotes Alk5
T3454 1648-1660 RB denotes specifically
T3455 1661-1663 IN denotes in
T3456 1664-1670 JJ denotes neural
T3457 1677-1682 NNS denotes cells
T3458 1671-1676 NN denotes crest
T3459 1682-1683 . denotes .
T3460 1683-1802 sentence denotes We discovered that in Alk5/Wnt1-Cre mutants, pharyngeal organs (thymus and parathyroid) fail to migrate appropriately.
T3461 1684-1686 PRP denotes We
T3462 1687-1697 VBD denotes discovered
T3463 1698-1702 IN denotes that
T3464 1772-1776 VBP denotes fail
T3465 1703-1705 IN denotes in
T3466 1706-1710 NN denotes Alk5
T3467 1716-1719 NN denotes Cre
T3468 1710-1711 HYPH denotes /
T3469 1711-1715 NN denotes Wnt1
T3470 1715-1716 HYPH denotes -
T3471 1720-1727 NNS denotes mutants
T3472 1727-1729 , denotes ,
T3473 1729-1739 JJ denotes pharyngeal
T3474 1740-1746 NNS denotes organs
T3475 1747-1748 -LRB- denotes (
T3476 1748-1754 NN denotes thymus
T3477 1755-1758 CC denotes and
T3478 1759-1770 NN denotes parathyroid
T3479 1770-1771 -RRB- denotes )
T3480 1777-1779 TO denotes to
T3481 1780-1787 VB denotes migrate
T3482 1788-1801 RB denotes appropriately
T3483 1801-1802 . denotes .
T3484 1802-1948 sentence denotes Moreover, the mutant embryos display severe aortic sac and pharyngeal arch artery defects, and failed aortico-pulmonary septation leading to PTA.
T3485 1803-1811 RB denotes Moreover
T3486 1832-1839 VBP denotes display
T3487 1811-1813 , denotes ,
T3488 1813-1816 DT denotes the
T3489 1824-1831 NNS denotes embryos
T3490 1817-1823 NN denotes mutant
T3491 1840-1846 JJ denotes severe
T3492 1854-1857 NN denotes sac
T3493 1847-1853 JJ denotes aortic
T3494 1885-1892 NNS denotes defects
T3495 1858-1861 CC denotes and
T3496 1862-1872 JJ denotes pharyngeal
T3497 1878-1884 NN denotes artery
T3498 1873-1877 NN denotes arch
T3499 1892-1894 , denotes ,
T3500 1894-1897 CC denotes and
T3501 1898-1904 VBD denotes failed
T3502 1905-1912 JJ denotes aortico
T3503 1913-1922 JJ denotes pulmonary
T3504 1912-1913 HYPH denotes -
T3505 1923-1932 NN denotes septation
T3506 1933-1940 VBG denotes leading
T3507 1941-1943 IN denotes to
T3508 1944-1947 NN denotes PTA
T3509 1947-1948 . denotes .
T3510 1948-2120 sentence denotes Our data further suggest that at least some of these abnormal detected phenotypes result from a dramatic increase in apoptosis of postmigratory cardiac neural crest cells.
T3511 1949-1952 PRP$ denotes Our
T3512 1953-1957 NNS denotes data
T3513 1966-1973 VBP denotes suggest
T3514 1958-1965 RB denotes further
T3515 1974-1978 IN denotes that
T3516 2031-2037 VBP denotes result
T3517 1979-1981 RB denotes at
T3518 1982-1987 RBS denotes least
T3519 1988-1992 DT denotes some
T3520 1993-1995 IN denotes of
T3521 1996-2001 DT denotes these
T3522 2020-2030 NNS denotes phenotypes
T3523 2002-2010 JJ denotes abnormal
T3524 2011-2019 VBN denotes detected
T3525 2038-2042 IN denotes from
T3526 2043-2044 DT denotes a
T3527 2054-2062 NN denotes increase
T3528 2045-2053 JJ denotes dramatic
T3529 2063-2065 IN denotes in
T3530 2066-2075 NN denotes apoptosis
T3531 2076-2078 IN denotes of
T3532 2079-2092 JJ denotes postmigratory
T3533 2114-2119 NNS denotes cells
T3534 2093-2100 JJ denotes cardiac
T3535 2108-2113 NN denotes crest
T3536 2101-2107 JJ denotes neural
T3537 2119-2120 . denotes .
T3538 2120-2387 sentence denotes These phenotypes differ remarkably from those seen in corresponding Tgfbr2 mutants, suggesting that ALK5 mediates a wider spectrum of signaling events than its classical binding partner TGFβRII in cardiac neural crest cells during cardiac and pharyngeal development.
T3539 2121-2126 DT denotes These
T3540 2127-2137 NNS denotes phenotypes
T3541 2138-2144 VBP denotes differ
T3542 2145-2155 RB denotes remarkably
T3543 2156-2160 IN denotes from
T3544 2161-2166 DT denotes those
T3545 2167-2171 VBN denotes seen
T3546 2172-2174 IN denotes in
T3547 2175-2188 VBG denotes corresponding
T3548 2196-2203 NNS denotes mutants
T3549 2189-2195 NN denotes Tgfbr2
T3550 2203-2205 , denotes ,
T3551 2205-2215 VBG denotes suggesting
T3552 2216-2220 IN denotes that
T3553 2226-2234 VBZ denotes mediates
T3554 2221-2225 NN denotes ALK5
T3555 2235-2236 DT denotes a
T3556 2243-2251 NN denotes spectrum
T3557 2237-2242 JJR denotes wider
T3558 2252-2254 IN denotes of
T3559 2255-2264 NN denotes signaling
T3560 2265-2271 NNS denotes events
T3561 2272-2276 IN denotes than
T3562 2277-2280 PRP$ denotes its
T3563 2299-2306 NN denotes partner
T3564 2281-2290 JJ denotes classical
T3565 2291-2298 NN denotes binding
T3566 2307-2314 NN denotes TGFβRII
T3567 2315-2317 IN denotes in
T3568 2318-2325 JJ denotes cardiac
T3569 2339-2344 NNS denotes cells
T3570 2326-2332 JJ denotes neural
T3571 2333-2338 NN denotes crest
T3572 2345-2351 IN denotes during
T3573 2352-2359 JJ denotes cardiac
T3574 2375-2386 NN denotes development
T3575 2360-2363 CC denotes and
T3576 2364-2374 JJ denotes pharyngeal
T3577 2386-2387 . denotes .
R617 T3153 T3152 pobj phosphorylation,to
R622 T3154 T3153 cc and,phosphorylation
R629 T3155 T3153 conj activation,phosphorylation
R633 T3156 T3153 prep of,phosphorylation
R638 T3157 T3158 nmod type,receptors
R641 T3158 T3156 pobj receptors,of
R645 T3159 T3157 nummod I,type
R648 T3160 T3153 punct ", ",phosphorylation
R652 T3161 T3162 dep which,phosphorylate
R654 T3162 T3153 relcl phosphorylate,phosphorylation
R656 T3163 T3162 punct ", ",phosphorylate
R658 T3164 T3162 prep in,phosphorylate
R662 T3165 T3164 pobj turn,in
R665 T3166 T3162 punct ", ",phosphorylate
R666 T3121 T3122 compound TGF,β
R667 T3122 T3124 compound β,ligands
R668 T3167 T3162 cc and,phosphorylate
R669 T3123 T3122 punct -,β
R670 T3124 T3126 nsubj ligands,signal
R671 T3125 T3124 compound subfamily,ligands
R672 T3168 T3162 conj activate,phosphorylate
R673 T3127 T3126 prep via,signal
R674 T3169 T3170 det a,set
R675 T3128 T3129 det a,complex
R676 T3129 T3127 pobj complex,via
R677 T3130 T3129 compound receptor,complex
R678 T3131 T3129 acl composed,complex
R679 T3132 T3131 prep of,composed
R680 T3170 T3168 dobj set,activate
R681 T3133 T3134 nummod two,receptors
R682 T3134 T3132 pobj receptors,of
R683 T3135 T3134 nmod type,receptors
R684 T3171 T3170 amod specific,set
R685 T3136 T3135 nummod II,type
R686 T3137 T3134 cc and,receptors
R687 T3138 T3139 nummod two,receptors
R688 T3172 T3170 prep of,set
R689 T3139 T3134 conj receptors,receptors
R690 T3140 T3139 nmod type,receptors
R691 T3173 T3174 amod downstream,molecules
R692 T3141 T3140 nummod I,type
R693 T3142 T3143 punct [,15
R694 T3174 T3172 pobj molecules,of
R695 T3143 T3126 parataxis 15,signal
R696 T3144 T3143 nummod 14,15
R697 T3145 T3143 punct ",",15
R698 T3146 T3143 punct ],15
R699 T3175 T3174 compound signaling,molecules
R700 T3147 T3126 punct .,signal
R701 T3176 T3174 acl called,molecules
R702 T3149 T3150 compound Ligand,binding
R703 T3150 T3151 nsubj binding,leads
R704 T3177 T3176 oprd Smads,called
R705 T3152 T3151 prep to,leads
R706 T3178 T3151 punct .,leads
R707 T3180 T3181 prep In,bind
R708 T3259 T3254 ccomp are,is
R709 T3182 T3183 amod general,terms
R710 T3260 T3261 det these,interactions
R711 T3261 T3259 nsubj interactions,are
R712 T3262 T3261 compound signaling,interactions
R713 T3183 T3180 pobj terms,In
R714 T3263 T3264 advmod more,complex
R715 T3184 T3181 punct ", ",bind
R716 T3264 T3259 acomp complex,are
R717 T3265 T3266 advmod in,vivo
R718 T3185 T3186 compound TGF,βs
R719 T3266 T3259 advmod vivo,are
R720 T3267 T3259 punct ", ",are
R721 T3268 T3269 advmod possibly,allowing
R722 T3186 T3181 nsubj βs,bind
R723 T3269 T3259 advcl allowing,are
R724 T3270 T3269 dobj formation,allowing
R725 T3271 T3270 prep of,formation
R726 T3187 T3186 punct -,βs
R727 T3272 T3273 amod heterotetrameric,complexes
R728 T3273 T3271 pobj complexes,of
R729 T3274 T3273 acl composed,complexes
R730 T3275 T3274 prep of,composed
R731 T3276 T3277 amod different,receptors
R732 T3277 T3275 pobj receptors,of
R733 T3188 T3181 prep to,bind
R734 T3278 T3277 nmod type,receptors
R735 T3279 T3278 nummod II,type
R736 T3280 T3278 cc and,type
R737 T3281 T3278 conj type,type
R738 T3189 T3190 det the,receptor
R739 T3282 T3281 nummod I,type
R740 T3283 T3284 punct [,16
R741 T3284 T3259 parataxis 16,are
R742 T3190 T3188 pobj receptor,to
R743 T3285 T3284 punct ],16
R744 T3286 T3254 punct .,is
R745 T3191 T3192 nmod TGF,β
R746 T3288 T3289 prep In,identified
R747 T3192 T3190 nmod β,receptor
R748 T3290 T3288 pobj addition,In
R749 T3291 T3289 punct ", ",identified
R750 T3292 T3293 amod recent,studies
R751 T3193 T3192 punct -,β
R752 T3293 T3289 nsubj studies,identified
R753 T3294 T3289 aux have,identified
R754 T3295 T3296 amod novel,ligands
R755 T3194 T3190 nmod type,receptor
R756 T3296 T3289 dobj ligands,identified
R757 T3297 T3298 compound TGF,β
R758 T3298 T3300 npadvmod β,related
R759 T3195 T3194 nummod II,type
R760 T3299 T3298 punct -,β
R761 T3300 T3296 amod related,ligands
R762 T3301 T3300 punct -,related
R763 T3196 T3190 punct (,receptor
R764 T3197 T3190 appos TGFβRII,receptor
R765 T3302 T3296 punct ", ",ligands
R766 T3303 T3304 dep which,bind
R767 T3304 T3296 relcl bind,ligands
R768 T3198 T3190 punct ),receptor
R769 T3305 T3304 aux can,bind
R770 T3306 T3304 prep to,bind
R771 T3199 T3190 cc and,receptor
R772 T3307 T3308 amod entire,combinations
R773 T3308 T3306 pobj combinations,to
R774 T3309 T3308 amod different,combinations
R775 T3200 T3201 nmod TGF,β
R776 T3310 T3308 prep of,combinations
R777 T3311 T3310 pobj receptors,of
R778 T3201 T3203 nmod β,receptor
R779 T3312 T3289 punct .,identified
R780 T3202 T3201 punct -,β
R781 T3314 T3315 prep For,bind
R782 T3316 T3314 pobj instance,For
R783 T3317 T3315 punct ", ",bind
R784 T3318 T3319 nmod growth,factors
R785 T3319 T3315 nsubj factors,bind
R786 T3203 T3190 conj receptor,receptor
R787 T3320 T3318 cc and,growth
R788 T3321 T3318 conj differentiation,growth
R789 T3322 T3319 punct (,factors
R790 T3323 T3319 appos GDFs,factors
R791 T3204 T3203 nmod type,receptor
R792 T3324 T3319 punct ),factors
R793 T3325 T3319 appos 8,factors
R794 T3205 T3204 nummod I,type
R795 T3326 T3325 cc and,8
R796 T3327 T3325 conj 9,8
R797 T3328 T3315 aux can,bind
R798 T3206 T3203 punct (,receptor
R801 T3331 T3329 pobj receptor,to
R802 T3332 T3331 nmod type,receptor
R803 T3207 T3203 appos ALK5,receptor
R804 T3333 T3332 nummod II,type
R805 T3334 T3331 cc and,receptor
R806 T3208 T3181 punct ),bind
R807 T3335 T3331 conj ALK5,receptor
R808 T3336 T3337 aux to,activate
R809 T3337 T3315 advcl activate,bind
R810 T3209 T3181 advcl activating,bind
R811 T3338 T3339 compound TGF,β
R812 T3339 T3341 compound β,Smads
R813 T3340 T3339 punct -,β
R814 T3210 T3211 compound TGF,β
R815 T3341 T3337 dobj Smads,activate
R816 T3342 T3343 punct [,18
R817 T3211 T3213 compound β,Smads
R818 T3343 T3315 parataxis 18,bind
R819 T3344 T3343 nummod 17,18
R820 T3345 T3343 punct ",",18
R821 T3212 T3211 punct -,β
R822 T3346 T3343 punct ],18
R823 T3347 T3315 punct .,bind
R824 T3213 T3209 dobj Smads,activating
R825 T3349 T3350 advmod Therefore,hypothesized
R826 T3214 T3215 punct (,2
R827 T3351 T3350 punct ", ",hypothesized
R828 T3352 T3350 nsubj we,hypothesized
R829 T3353 T3354 mark that,reveal
R830 T3215 T3209 parataxis 2,activating
R832 T3355 T3354 nsubj deletion,reveal
R833 T3356 T3355 prep of,deletion
R834 T3357 T3356 pobj Alk5,of
R835 T3358 T3355 prep in,deletion
R836 T3359 T3360 det a,lineage
R837 T3216 T3215 cc and,2
R838 T3360 T3358 pobj lineage,in
R839 T3361 T3360 amod specific,lineage
R840 T3362 T3360 compound cell,lineage
R841 T3217 T3215 conj 3,2
R842 T3363 T3354 aux should,reveal
R843 T3364 T3354 dobj phenotypes,reveal
R844 T3218 T3215 punct ),2
R845 T3219 T3181 punct ", ",bind
R846 T3220 T3221 mark while,bind
R847 T3221 T3181 advcl bind,bind
R848 T3365 T3366 dep which,seen
R849 T3366 T3364 relcl seen,phenotypes
R850 T3222 T3221 nsubj BMPs,bind
R851 T3367 T3366 aux can,seen
R852 T3368 T3366 neg not,seen
R853 T3369 T3366 auxpass be,seen
R854 T3223 T3221 prep to,bind
R855 T3370 T3366 prep in,seen
R856 T3371 T3372 amod comparable,mutants
R857 T3224 T3225 det the,ALK2
R858 T3372 T3370 pobj mutants,in
R859 T3373 T3372 acl lacking,mutants
R860 T3225 T3223 pobj ALK2,to
R861 T3374 T3373 dobj Tgfbr2,lacking
R862 T3375 T3350 punct .,hypothesized
R863 T3226 T3225 nmod BMP,ALK2
R864 T3377 T3378 advmod Indeed,showed
R865 T3378 T3382 ccomp showed,seen
R866 T3379 T3378 punct ", ",showed
R867 T3227 T3228 nmod type,receptor
R868 T3380 T3378 nsubj we,showed
R869 T3381 T3378 advmod recently,showed
R870 T3228 T3225 nmod receptor,ALK2
R871 T3383 T3384 mark that,display
R872 T3229 T3227 nummod II,type
R873 T3230 T3228 cc and,receptor
R874 T3384 T3378 ccomp display,showed
R875 T3231 T3232 nmod type,receptors
R876 T3385 T3386 amod neural,cell
R877 T3386 T3388 npadvmod cell,specific
R878 T3387 T3386 compound crest,cell
R879 T3232 T3228 conj receptors,receptor
R880 T3388 T3389 amod specific,mutants
R881 T3389 T3384 nsubj mutants,display
R882 T3233 T3231 nummod I,type
R883 T3390 T3389 compound Alk5,mutants
R884 T3391 T3392 det a,spectrum
R885 T3392 T3384 dobj spectrum,display
R886 T3393 T3392 amod unique,spectrum
R887 T3394 T3392 prep of,spectrum
R888 T3234 T3225 punct ", ",ALK2
R889 T3395 T3396 amod craniofacial,defects
R890 T3396 T3394 pobj defects,of
R891 T3397 T3396 amod developmental,defects
R892 T3235 T3225 punct -,ALK2
R893 T3398 T3396 punct ", ",defects
R894 T3399 T3400 advmod e.g.,snout
R895 T3236 T3225 nummod 3,ALK2
R896 T3400 T3396 appos snout,defects
R897 T3401 T3400 punct ", ",snout
R898 T3237 T3225 punct ", ",ALK2
R899 T3402 T3400 compound cleft,snout
R900 T3403 T3400 cc and,snout
R901 T3404 T3405 amod severe,hypoplasia
R902 T3238 T3225 cc or,ALK2
R903 T3405 T3400 conj hypoplasia,snout
R904 T3406 T3405 amod mandibular,hypoplasia
R905 T3407 T3408 punct [,19
R906 T3239 T3225 conj 6,ALK2
R907 T3408 T3378 parataxis 19,showed
R908 T3409 T3408 punct ],19
R909 T3240 T3221 punct ", ",bind
R910 T3410 T3382 punct ;,seen
R911 T3411 T3412 det these,phenotypes
R912 T3412 T3382 nsubjpass phenotypes,seen
R913 T3241 T3221 advcl activating,bind
R914 T3413 T3382 auxpass were,seen
R915 T3414 T3382 neg not,seen
R916 T3242 T3243 compound BMP,Smads
R917 T3415 T3382 prep in,seen
R918 T3416 T3417 amod corresponding,mutants
R919 T3417 T3415 pobj mutants,in
R920 T3243 T3241 dobj Smads,activating
R921 T3418 T3417 compound Tgfbr2,mutants
R922 T3419 T3420 punct [,20
R923 T3420 T3382 parataxis 20,seen
R924 T3244 T3245 punct (,1
R925 T3421 T3420 punct ],20
R926 T3422 T3382 punct .,seen
R927 T3245 T3181 parataxis 1,bind
R928 T3424 T3425 aux To,determine
R929 T3425 T3426 advcl determine,focused
R930 T3246 T3245 punct ", ",1
R931 T3427 T3425 punct ", ",determine
R932 T3247 T3245 conj 5,1
R933 T3428 T3429 mark whether,mediate
R934 T3429 T3425 ccomp mediate,determine
R935 T3430 T3429 nsubj ALK5,mediate
R936 T3248 T3247 cc and,5
R937 T3431 T3429 aux would,mediate
R938 T3432 T3429 advmod also,mediate
R939 T3433 T3434 amod unique,events
R940 T3434 T3429 dobj events,mediate
R941 T3249 T3247 conj 8,5
R942 T3435 T3434 amod non-redundant,events
R943 T3436 T3434 compound signaling,events
R944 T3437 T3429 prep in,mediate
R945 T3250 T3245 punct ),1
R946 T3438 T3439 amod cardiac,crest
R947 T3439 T3441 compound crest,cells
R948 T3440 T3439 amod neural,crest
R949 T3251 T3181 punct .,bind
R950 T3441 T3437 pobj cells,in
R951 T3442 T3426 punct ", ",focused
R952 T3443 T3426 nsubj we,focused
R953 T3253 T3254 advmod However,is
R954 T3444 T3426 prep on,focused
R955 T3445 T3446 amod cardiac,phenotypes
R956 T3255 T3254 punct ", ",is
R957 T3446 T3444 pobj phenotypes,on
R958 T3447 T3445 cc and,cardiac
R959 T3256 T3254 nsubj it,is
R960 T3448 T3445 conj pharyngeal,cardiac
R961 T3449 T3446 prep of,phenotypes
R962 T3450 T3451 compound mouse,embryos
R963 T3257 T3254 acomp likely,is
R964 T3451 T3449 pobj embryos,of
R965 T3452 T3451 acl lacking,embryos
R966 T3453 T3452 dobj Alk5,lacking
R967 T3258 T3259 mark that,are
R968 T3454 T3455 advmod specifically,in
R969 T3455 T3426 prep in,focused
R970 T3471 T3465 pobj mutants,in
R971 T3456 T3457 amod neural,cells
R972 T3457 T3455 pobj cells,in
R973 T3458 T3457 compound crest,cells
R974 T3459 T3426 punct .,focused
R975 T3472 T3464 punct ", ",fail
R976 T3461 T3462 nsubj We,discovered
R977 T3463 T3464 mark that,fail
R978 T3473 T3474 amod pharyngeal,organs
R979 T3464 T3462 ccomp fail,discovered
R980 T3465 T3464 prep in,fail
R981 T3474 T3464 nsubj organs,fail
R982 T3466 T3467 compound Alk5,Cre
R983 T3467 T3471 compound Cre,mutants
R984 T3468 T3467 punct /,Cre
R985 T3475 T3474 punct (,organs
R986 T3469 T3467 compound Wnt1,Cre
R987 T3470 T3467 punct -,Cre
R988 T3476 T3474 appos thymus,organs
R989 T3477 T3476 cc and,thymus
R990 T3478 T3476 conj parathyroid,thymus
R991 T3577 T3541 punct .,differ
R992 T3479 T3464 punct ),fail
R993 T3480 T3481 aux to,migrate
R994 T3481 T3464 xcomp migrate,fail
R995 T3482 T3481 advmod appropriately,migrate
R996 T3483 T3462 punct .,discovered
R997 T3485 T3486 advmod Moreover,display
R998 T3487 T3486 punct ", ",display
R999 T3488 T3489 det the,embryos
R1000 T3489 T3486 nsubj embryos,display
R1001 T3490 T3489 compound mutant,embryos
R1002 T3491 T3492 amod severe,sac
R1003 T3492 T3494 nmod sac,defects
R1004 T3493 T3492 amod aortic,sac
R1005 T3494 T3486 dobj defects,display
R1006 T3495 T3492 cc and,sac
R1007 T3496 T3497 amod pharyngeal,artery
R1008 T3497 T3492 conj artery,sac
R1009 T3498 T3497 compound arch,artery
R1010 T3499 T3486 punct ", ",display
R1011 T3500 T3486 cc and,display
R1012 T3501 T3486 conj failed,display
R1013 T3502 T3503 amod aortico,pulmonary
R1014 T3503 T3505 amod pulmonary,septation
R1015 T3504 T3503 punct -,pulmonary
R1016 T3505 T3501 dobj septation,failed
R1017 T3506 T3505 acl leading,septation
R1018 T3507 T3506 prep to,leading
R1019 T3508 T3507 pobj PTA,to
R1020 T3509 T3486 punct .,display
R1021 T3511 T3512 poss Our,data
R1022 T3512 T3513 nsubj data,suggest
R1023 T3514 T3513 advmod further,suggest
R1024 T3515 T3516 mark that,result
R1025 T3516 T3513 ccomp result,suggest
R1026 T3517 T3518 advmod at,least
R1027 T3518 T3519 advmod least,some
R1028 T3519 T3516 nsubj some,result
R1029 T3520 T3519 prep of,some
R1030 T3521 T3522 det these,phenotypes
R1031 T3522 T3520 pobj phenotypes,of
R1032 T3523 T3522 amod abnormal,phenotypes
R1033 T3524 T3522 amod detected,phenotypes
R1034 T3525 T3516 prep from,result
R1035 T3526 T3527 det a,increase
R1036 T3527 T3525 pobj increase,from
R1037 T3528 T3527 amod dramatic,increase
R1038 T3529 T3527 prep in,increase
R1039 T3530 T3529 pobj apoptosis,in
R1040 T3531 T3530 prep of,apoptosis
R1041 T3532 T3533 amod postmigratory,cells
R1042 T3533 T3531 pobj cells,of
R1043 T3534 T3535 amod cardiac,crest
R1044 T3535 T3533 compound crest,cells
R1045 T3536 T3535 amod neural,crest
R1046 T3537 T3513 punct .,suggest
R1047 T3539 T3540 det These,phenotypes
R1048 T3540 T3541 nsubj phenotypes,differ
R1049 T3542 T3541 advmod remarkably,differ
R1050 T3543 T3541 prep from,differ
R1051 T3544 T3543 pobj those,from
R1052 T3545 T3544 acl seen,those
R1053 T3546 T3545 prep in,seen
R1054 T3547 T3548 amod corresponding,mutants
R1055 T3548 T3546 pobj mutants,in
R1056 T3549 T3548 compound Tgfbr2,mutants
R1057 T3550 T3545 punct ", ",seen
R1058 T3551 T3545 advcl suggesting,seen
R1059 T3552 T3553 mark that,mediates
R1060 T3553 T3551 ccomp mediates,suggesting
R1061 T3554 T3553 nsubj ALK5,mediates
R1062 T3555 T3556 det a,spectrum
R1063 T3556 T3553 dobj spectrum,mediates
R1064 T3557 T3556 amod wider,spectrum
R1065 T3558 T3556 prep of,spectrum
R1066 T3559 T3560 compound signaling,events
R1067 T3560 T3558 pobj events,of
R1068 T3561 T3556 prep than,spectrum
R1069 T3562 T3563 poss its,partner
R1070 T3563 T3561 pobj partner,than
R1071 T3564 T3563 amod classical,partner
R1072 T3565 T3563 compound binding,partner
R1073 T3566 T3563 appos TGFβRII,partner
R1074 T3567 T3553 prep in,mediates
R1075 T3568 T3569 amod cardiac,cells
R1076 T3569 T3567 pobj cells,in
R1077 T3570 T3569 amod neural,cells
R1078 T3571 T3569 compound crest,cells
R1079 T3572 T3553 prep during,mediates
R1080 T3573 T3574 amod cardiac,development
R1081 T3574 T3572 pobj development,during
R1082 T3575 T3573 cc and,cardiac
R1083 T3576 T3573 conj pharyngeal,cardiac
R799 T3329 T3315 prep to,bind
R800 T3330 T3331 nmod Activin,receptor
R831 T3354 T3350 ccomp reveal,hypothesized

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2571 0-5 PR_EXT:000000046 denotes TGF-β
T2572 16-23 CHEBI_GO_EXT:ligand denotes ligands
T2573 24-30 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signal
T2574 37-45 GO_EXT:0004872 denotes receptor
T2575 37-53 GO:0043235 denotes receptor complex
T2576 70-87 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes type II receptors
T2577 96-112 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_I denotes type I receptors
T2578 122-128 CHEBI_GO_EXT:ligand denotes Ligand
T2579 129-136 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T2580 146-161 GO_PATO_EXT:phosphorylation_process denotes phosphorylation
T2581 180-196 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_I denotes type I receptors
T2582 214-227 GO_PATO_EXT:phosphorylation_process denotes phosphorylate
T2583 270-279 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T2584 270-289 CHEBI_EXT:62488 denotes signaling molecules
T2585 297-302 GO_PR_EXT:SMAD denotes Smads
T2586 322-328 PR_EXT:000000046 denotes TGF-βs
T2587 329-333 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T2588 341-363 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes TGF-β type II receptor
T2589 365-372 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes TGFβRII
T2590 378-399 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_I denotes TGF-β type I receptor
T2591 401-405 PR_EXT:000000047 denotes ALK5
T2592 418-429 PR_EXT:000000066 denotes TGF-β Smads
T2593 424-429 GO_PR_EXT:SMAD denotes Smads
T2594 424-429 _FRAGMENT denotes Smads
T2595 431-432 PR_EXT:000000364 denotes 2
T2597 447-451 PR_EXT:000000034 denotes BMPs
T2598 452-456 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T2599 464-484 PR_EXT:000000037 denotes BMP type II receptor
T2600 464-467 _FRAGMENT denotes BMP
T2601 489-505 PR_EXT:BMP_type_1_receptor denotes type I receptors
T2602 476-484 GO_EXT:0004872 denotes receptor
T2603 506-510 PR_EXT:000000067 denotes ALK2
T2604 533-542 PR_EXT:000000038 denotes BMP Smads
T2605 537-542 GO_PR_EXT:SMAD denotes Smads
T2606 537-542 _FRAGMENT denotes Smads
T2607 544-545 PR_EXT:000000363 denotes 1
T2608 547-548 PR_EXT:000000372 denotes 5
T2609 553-554 PR_EXT:000000375 denotes 8
T2610 590-599 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T2611 657-696 GO:0051290 denotes formation of heterotetrameric complexes
T2612 676-696 GO_EXT:tetrameric_macromolecular_complex denotes tetrameric complexes
T2613 738-747 GO_EXT:0004872 denotes receptors
T2614 804-809 PR_EXT:000000046 denotes TGF-β
T2615 818-825 CHEBI_GO_EXT:ligand denotes ligands
T2616 837-841 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T2617 878-887 GO_EXT:0004872 denotes receptors
T2618 903-909 GO_EXT:biological_growth_entity_or_process denotes growth
T2619 903-909 _FRAGMENT denotes growth
T2620 930-937 GO_EXT:0008083 denotes factors
T2621 903-937 _FRAGMENT denotes growth and differentiation factors
T2622 945-946 PR_EXT:000010684 denotes 8
T2623 951-952 PR_EXT:000007925 denotes 9
T2624 914-929 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T2625 939-943 _FRAGMENT denotes GDFs
T2626 957-961 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T2627 965-972 GO:0048180 denotes Activin
T2628 965-989 GO_PR_EXT:activin_receptor_type_II denotes Activin type II receptor
T2629 994-998 PR_EXT:000000047 denotes ALK5
T2630 1011-1022 PR_EXT:000000066 denotes TGF-β Smads
T2631 1017-1022 GO_PR_EXT:SMAD denotes Smads
T2632 1064-1072 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T2633 1076-1080 PR_EXT:000000047 denotes Alk5
T2634 1095-1099 CL_GO_EXT:cell denotes cell
T2635 1168-1175 SO_EXT:sequence_altered_entity denotes mutants
T2636 1184-1190 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T2637 1224-1236 UBERON:0002342 denotes neural crest
T2638 1224-1241 CL_EXT:neural_crest_cell denotes neural crest cell
T2639 1237-1241 CL_GO_EXT:cell denotes cell
T2640 1251-1255 PR_EXT:000000047 denotes Alk5
T2641 1256-1263 SO_EXT:sequence_altered_entity denotes mutants
T2642 1293-1305 UBERON_EXT:face_or_skull denotes craniofacial
T2643 1341-1346 UBERON:0006333 denotes snout
T2644 1358-1368 UBERON:0001684 denotes mandibular
T2645 1434-1440 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T2646 1441-1448 SO_EXT:sequence_altered_entity denotes mutants
T2647 1477-1481 PR_EXT:000000047 denotes ALK5
T2648 1522-1531 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T2649 1542-1562 UBERON:0000095 denotes cardiac neural crest
T2650 1550-1568 CL_EXT:neural_crest_cell denotes neural crest cells
T2651 1563-1568 CL_GO_EXT:cell denotes cells
T2652 1584-1591 UBERON:0000948 denotes cardiac
T2653 1596-1606 UBERON:0006562 denotes pharyngeal
T2654 1621-1626 NCBITaxon:10088 denotes mouse
T2655 1627-1634 UBERON:0000922 denotes embryos
T2656 1643-1647 PR_EXT:000000047 denotes Alk5
T2657 1664-1676 UBERON:0002342 denotes neural crest
T2658 1664-1682 CL_EXT:neural_crest_cell denotes neural crest cells
T2659 1677-1682 CL_GO_EXT:cell denotes cells
T2660 1706-1710 PR_EXT:000000047 denotes Alk5
T2661 1711-1715 PR_EXT:000017435 denotes Wnt1
T2662 1720-1727 SO_EXT:sequence_altered_entity denotes mutants
T2663 1729-1739 UBERON:0006562 denotes pharyngeal
T2664 1740-1746 UBERON:0000062 denotes organs
T2665 1748-1754 UBERON:0002370 denotes thymus
T2666 1759-1770 UBERON:0001132 denotes parathyroid
T2667 1780-1787 GO_EXT:biological_movement_or_translocation_process denotes migrate
T2668 1817-1823 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2669 1824-1831 UBERON:0000922 denotes embryos
T2670 1847-1857 UBERON:0005432 denotes aortic sac
T2671 1862-1884 UBERON:0004363 denotes pharyngeal arch artery
T2672 1905-1912 UBERON:0000947 denotes aortico
T2673 1913-1922 UBERON:0002048 denotes pulmonary
T2674 2066-2078 _FRAGMENT denotes apoptosis of
T2675 2114-2119 GO:0006915 denotes cells
T2676 2083-2092 GO_EXT:biological_movement_or_translocation_process denotes migratory
T2677 2093-2113 UBERON:0000095 denotes cardiac neural crest
T2678 2101-2119 CL_EXT:neural_crest_cell denotes neural crest cells
T2679 2114-2119 CL_GO_EXT:cell denotes cells
T2680 2189-2195 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T2681 2196-2203 SO_EXT:sequence_altered_entity denotes mutants
T2682 2221-2225 PR_EXT:000000047 denotes ALK5
T2683 2255-2264 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T2684 2291-2298 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T2685 2307-2314 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes TGFβRII
T2686 2318-2338 UBERON:0000095 denotes cardiac neural crest
T2687 2326-2344 CL_EXT:neural_crest_cell denotes neural crest cells
T2688 2339-2344 CL_GO_EXT:cell denotes cells
T2689 2352-2359 UBERON:0000948 denotes cardiac
T2690 2352-2359 _FRAGMENT denotes cardiac
T2691 2375-2386 GO:0007507 denotes development
T2692 2364-2374 UBERON:0006562 denotes pharyngeal
T2693 2364-2386 GO:0060465 denotes pharyngeal development
T2596 437-438 PR_EXT:000000365 denotes 3
R232 T2595 T2594 _lexicallyChainedTo 2,Smads
R233 T2596 T2594 _lexicallyChainedTo 3,Smads
R234 T2601 T2600 _lexicallyChainedTo type I receptors,BMP
R235 T2607 T2606 _lexicallyChainedTo 1,Smads
R236 T2608 T2606 _lexicallyChainedTo 5,Smads
R237 T2609 T2606 _lexicallyChainedTo 8,Smads
R238 T2620 T2619 _lexicallyChainedTo factors,growth
R239 T2622 T2621 _lexicallyChainedTo 8,growth and differentiation factors
R240 T2622 T2625 _lexicallyChainedTo 8,GDFs
R241 T2623 T2621 _lexicallyChainedTo 9,growth and differentiation factors
R242 T2623 T2625 _lexicallyChainedTo 9,GDFs
R243 T2675 T2674 _lexicallyChainedTo cells,apoptosis of
R244 T2691 T2690 _lexicallyChainedTo development,cardiac

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2424 0-5 PR:000000046 denotes TGF-β
T2425 37-53 GO:0043235 denotes receptor complex
T2426 270-289 CHEBI:62488 denotes signaling molecules
T2427 322-328 PR:000000046 denotes TGF-βs
T2428 341-346 PR:000000046 denotes TGF-β
T2429 378-383 PR:000000046 denotes TGF-β
T2430 401-405 PR:000000047 denotes ALK5
T2431 418-429 PR:000000066 denotes TGF-β Smads
T2432 424-429 _FRAGMENT denotes Smads
T2433 431-432 PR:000000364 denotes 2
T2434 437-438 PR:000000365 denotes 3
T2435 447-451 PR:000000034 denotes BMPs
T2436 464-484 PR:000000037 denotes BMP type II receptor
T2437 506-510 PR:000000067 denotes ALK2
T2438 533-542 PR:000000038 denotes BMP Smads
T2439 537-542 _FRAGMENT denotes Smads
T2440 544-545 PR:000000363 denotes 1
T2441 547-548 PR:000000372 denotes 5
T2442 553-554 PR:000000375 denotes 8
T2443 657-696 GO:0051290 denotes formation of heterotetrameric complexes
T2444 804-809 PR:000000046 denotes TGF-β
T2445 903-937 _FRAGMENT denotes growth and differentiation factors
T2446 945-946 PR:000010684 denotes 8
T2447 951-952 PR:000007925 denotes 9
T2448 939-943 _FRAGMENT denotes GDFs
T2449 965-972 GO:0048180 denotes Activin
T2450 994-998 PR:000000047 denotes ALK5
T2451 1011-1022 PR:000000066 denotes TGF-β Smads
T2452 1076-1080 PR:000000047 denotes Alk5
T2453 1224-1236 UBERON:0002342 denotes neural crest
T2454 1251-1255 PR:000000047 denotes Alk5
T2455 1341-1346 UBERON:0006333 denotes snout
T2456 1358-1368 UBERON:0001684 denotes mandibular
T2457 1477-1481 PR:000000047 denotes ALK5
T2458 1542-1562 UBERON:0000095 denotes cardiac neural crest
T2459 1584-1591 UBERON:0000948 denotes cardiac
T2460 1596-1606 UBERON:0006562 denotes pharyngeal
T2461 1621-1626 NCBITaxon:10088 denotes mouse
T2462 1627-1634 UBERON:0000922 denotes embryos
T2463 1643-1647 PR:000000047 denotes Alk5
T2464 1664-1676 UBERON:0002342 denotes neural crest
T2465 1706-1710 PR:000000047 denotes Alk5
T2466 1711-1715 PR:000017435 denotes Wnt1
T2467 1729-1739 UBERON:0006562 denotes pharyngeal
T2468 1740-1746 UBERON:0000062 denotes organs
T2469 1748-1754 UBERON:0002370 denotes thymus
T2470 1759-1770 UBERON:0001132 denotes parathyroid
T2471 1824-1831 UBERON:0000922 denotes embryos
T2472 1847-1857 UBERON:0005432 denotes aortic sac
T2473 1862-1884 UBERON:0004363 denotes pharyngeal arch artery
T2474 1905-1912 UBERON:0000947 denotes aortico
T2475 1913-1922 UBERON:0002048 denotes pulmonary
T2476 2066-2078 _FRAGMENT denotes apoptosis of
T2477 2114-2119 GO:0006915 denotes cells
T2478 2093-2113 UBERON:0000095 denotes cardiac neural crest
T2479 2221-2225 PR:000000047 denotes ALK5
T2480 2318-2338 UBERON:0000095 denotes cardiac neural crest
T2481 2352-2359 UBERON:0000948 denotes cardiac
T2482 2352-2359 _FRAGMENT denotes cardiac
T2483 2375-2386 GO:0007507 denotes development
T2484 2364-2374 UBERON:0006562 denotes pharyngeal
T2485 2364-2386 GO:0060465 denotes pharyngeal development
R215 T2433 T2432 _lexicallyChainedTo 2,Smads
R216 T2434 T2432 _lexicallyChainedTo 3,Smads
R217 T2440 T2439 _lexicallyChainedTo 1,Smads
R218 T2441 T2439 _lexicallyChainedTo 5,Smads
R219 T2442 T2439 _lexicallyChainedTo 8,Smads
R220 T2446 T2445 _lexicallyChainedTo 8,growth and differentiation factors
R221 T2446 T2448 _lexicallyChainedTo 8,GDFs
R222 T2447 T2445 _lexicallyChainedTo 9,growth and differentiation factors
R223 T2447 T2448 _lexicallyChainedTo 9,GDFs
R224 T2477 T2476 _lexicallyChainedTo cells,apoptosis of
R225 T2483 T2482 _lexicallyChainedTo development,cardiac