PMC:1635039 / 27999-28390 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1635039","sourcedb":"PMC","sourceid":"1635039","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1635039","text":" Secondly, the NCC death seen in Alk5 mutants affects a predominantly postmigratory population of NCCs, while genes located in the DGCR, i.e., Tbx1 and CrkL, control NCC survival earlier at E8.5-E10 by regulating proliferation of the secondary heart field (SHF), and endoderm expansion, which in turn provides survival signal for NCCs allowing them to populate the pharyngeal region [36-39].","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T14882","span":{"begin":0,"end":391},"obj":"sentence"},{"id":"T14883","span":{"begin":1,"end":9},"obj":"RB"},{"id":"T14884","span":{"begin":46,"end":53},"obj":"VBZ"},{"id":"T14885","span":{"begin":9,"end":11},"obj":","},{"id":"T14886","span":{"begin":11,"end":14},"obj":"DT"},{"id":"T14887","span":{"begin":19,"end":24},"obj":"NN"},{"id":"T14888","span":{"begin":15,"end":18},"obj":"NN"},{"id":"T14889","span":{"begin":25,"end":29},"obj":"VBN"},{"id":"T14890","span":{"begin":30,"end":32},"obj":"IN"},{"id":"T14891","span":{"begin":33,"end":37},"obj":"NN"},{"id":"T14892","span":{"begin":38,"end":45},"obj":"NNS"},{"id":"T14893","span":{"begin":54,"end":55},"obj":"DT"},{"id":"T14894","span":{"begin":84,"end":94},"obj":"NN"},{"id":"T14895","span":{"begin":56,"end":69},"obj":"RB"},{"id":"T14896","span":{"begin":70,"end":83},"obj":"JJ"},{"id":"T14897","span":{"begin":95,"end":97},"obj":"IN"},{"id":"T14898","span":{"begin":98,"end":102},"obj":"NNS"},{"id":"T14899","span":{"begin":102,"end":104},"obj":","},{"id":"T14900","span":{"begin":104,"end":109},"obj":"IN"},{"id":"T14901","span":{"begin":158,"end":165},"obj":"VBP"},{"id":"T14902","span":{"begin":110,"end":115},"obj":"NNS"},{"id":"T14903","span":{"begin":116,"end":123},"obj":"VBN"},{"id":"T14904","span":{"begin":124,"end":126},"obj":"IN"},{"id":"T14905","span":{"begin":127,"end":130},"obj":"DT"},{"id":"T14906","span":{"begin":131,"end":135},"obj":"NN"},{"id":"T14907","span":{"begin":135,"end":137},"obj":","},{"id":"T14908","span":{"begin":137,"end":141},"obj":"FW"},{"id":"T14909","span":{"begin":143,"end":147},"obj":"NN"},{"id":"T14910","span":{"begin":141,"end":143},"obj":","},{"id":"T14911","span":{"begin":148,"end":151},"obj":"CC"},{"id":"T14912","span":{"begin":152,"end":156},"obj":"NN"},{"id":"T14913","span":{"begin":156,"end":158},"obj":","},{"id":"T14914","span":{"begin":166,"end":169},"obj":"NN"},{"id":"T14915","span":{"begin":170,"end":178},"obj":"NN"},{"id":"T14916","span":{"begin":179,"end":186},"obj":"RB"},{"id":"T14917","span":{"begin":187,"end":189},"obj":"IN"},{"id":"T14918","span":{"begin":190,"end":194},"obj":"NN"},{"id":"T14919","span":{"begin":194,"end":195},"obj":"SYM"},{"id":"T14920","span":{"begin":195,"end":198},"obj":"NN"},{"id":"T14921","span":{"begin":199,"end":201},"obj":"IN"},{"id":"T14922","span":{"begin":202,"end":212},"obj":"VBG"},{"id":"T14923","span":{"begin":213,"end":226},"obj":"NN"},{"id":"T14924","span":{"begin":227,"end":229},"obj":"IN"},{"id":"T14925","span":{"begin":230,"end":233},"obj":"DT"},{"id":"T14926","span":{"begin":250,"end":255},"obj":"NN"},{"id":"T14927","span":{"begin":234,"end":243},"obj":"JJ"},{"id":"T14928","span":{"begin":244,"end":249},"obj":"NN"},{"id":"T14929","span":{"begin":256,"end":257},"obj":"-LRB-"},{"id":"T14930","span":{"begin":257,"end":260},"obj":"NN"},{"id":"T14931","span":{"begin":260,"end":261},"obj":"-RRB-"},{"id":"T14932","span":{"begin":261,"end":263},"obj":","},{"id":"T14933","span":{"begin":263,"end":266},"obj":"CC"},{"id":"T14934","span":{"begin":267,"end":275},"obj":"NN"},{"id":"T14935","span":{"begin":276,"end":285},"obj":"NN"},{"id":"T14936","span":{"begin":285,"end":287},"obj":","},{"id":"T14937","span":{"begin":287,"end":292},"obj":"WDT"},{"id":"T14938","span":{"begin":301,"end":309},"obj":"VBZ"},{"id":"T14939","span":{"begin":293,"end":295},"obj":"IN"},{"id":"T14940","span":{"begin":296,"end":300},"obj":"NN"},{"id":"T14941","span":{"begin":310,"end":318},"obj":"NN"},{"id":"T14942","span":{"begin":319,"end":325},"obj":"NN"},{"id":"T14943","span":{"begin":326,"end":329},"obj":"IN"},{"id":"T14944","span":{"begin":330,"end":334},"obj":"NNS"},{"id":"T14945","span":{"begin":335,"end":343},"obj":"VBG"},{"id":"T14946","span":{"begin":344,"end":348},"obj":"PRP"},{"id":"T14947","span":{"begin":349,"end":351},"obj":"TO"},{"id":"T14948","span":{"begin":352,"end":360},"obj":"VB"},{"id":"T14949","span":{"begin":361,"end":364},"obj":"DT"},{"id":"T14950","span":{"begin":376,"end":382},"obj":"NN"},{"id":"T14951","span":{"begin":365,"end":375},"obj":"JJ"},{"id":"T14952","span":{"begin":383,"end":384},"obj":"-LRB-"},{"id":"T14953","span":{"begin":384,"end":386},"obj":"CD"},{"id":"T14954","span":{"begin":386,"end":387},"obj":"SYM"},{"id":"T14955","span":{"begin":387,"end":389},"obj":"CD"},{"id":"T14956","span":{"begin":389,"end":390},"obj":"-RRB-"},{"id":"T14957","span":{"begin":390,"end":391},"obj":"."}],"relations":[{"id":"R4318","pred":"acl","subj":"T14889","obj":"T14887"},{"id":"R4322","pred":"prep","subj":"T14890","obj":"T14889"},{"id":"R4326","pred":"compound","subj":"T14891","obj":"T14892"},{"id":"R4330","pred":"pobj","subj":"T14892","obj":"T14890"},{"id":"R4334","pred":"det","subj":"T14893","obj":"T14894"},{"id":"R4337","pred":"dobj","subj":"T14894","obj":"T14884"},{"id":"R4341","pred":"advmod","subj":"T14895","obj":"T14896"},{"id":"R4345","pred":"amod","subj":"T14896","obj":"T14894"},{"id":"R4348","pred":"prep","subj":"T14897","obj":"T14894"},{"id":"R4352","pred":"pobj","subj":"T14898","obj":"T14897"},{"id":"R4356","pred":"punct","subj":"T14899","obj":"T14884"},{"id":"R4360","pred":"mark","subj":"T14900","obj":"T14901"},{"id":"R4364","pred":"advmod","subj":"T14883","obj":"T14884"},{"id":"R4365","pred":"advcl","subj":"T14901","obj":"T14884"},{"id":"R4366","pred":"punct","subj":"T14885","obj":"T14884"},{"id":"R4367","pred":"det","subj":"T14886","obj":"T14887"},{"id":"R4368","pred":"nsubj","subj":"T14902","obj":"T14901"},{"id":"R4369","pred":"nsubj","subj":"T14887","obj":"T14884"},{"id":"R4370","pred":"compound","subj":"T14888","obj":"T14887"},{"id":"R4371","pred":"acl","subj":"T14903","obj":"T14902"},{"id":"R4372","pred":"prep","subj":"T14904","obj":"T14903"},{"id":"R4373","pred":"det","subj":"T14905","obj":"T14906"},{"id":"R4376","pred":"pobj","subj":"T14906","obj":"T14904"},{"id":"R4380","pred":"punct","subj":"T14907","obj":"T14906"},{"id":"R4381","pred":"advmod","subj":"T14908","obj":"T14909"},{"id":"R4384","pred":"appos","subj":"T14909","obj":"T14906"},{"id":"R4387","pred":"punct","subj":"T14910","obj":"T14909"},{"id":"R4391","pred":"cc","subj":"T14911","obj":"T14909"},{"id":"R4394","pred":"conj","subj":"T14912","obj":"T14909"},{"id":"R4397","pred":"punct","subj":"T14913","obj":"T14901"},{"id":"R4400","pred":"compound","subj":"T14914","obj":"T14915"},{"id":"R4401","pred":"dobj","subj":"T14915","obj":"T14901"},{"id":"R4402","pred":"advmod","subj":"T14916","obj":"T14901"},{"id":"R4405","pred":"prep","subj":"T14917","obj":"T14901"},{"id":"R4408","pred":"pobj","subj":"T14918","obj":"T14917"},{"id":"R4412","pred":"punct","subj":"T14919","obj":"T14920"},{"id":"R4419","pred":"prep","subj":"T14920","obj":"T14918"},{"id":"R4423","pred":"prep","subj":"T14921","obj":"T14901"},{"id":"R4427","pred":"pcomp","subj":"T14922","obj":"T14921"},{"id":"R4430","pred":"dobj","subj":"T14923","obj":"T14922"},{"id":"R4433","pred":"prep","subj":"T14924","obj":"T14923"},{"id":"R4438","pred":"det","subj":"T14925","obj":"T14926"},{"id":"R4442","pred":"pobj","subj":"T14926","obj":"T14924"},{"id":"R4445","pred":"amod","subj":"T14927","obj":"T14926"},{"id":"R4448","pred":"compound","subj":"T14928","obj":"T14926"},{"id":"R4452","pred":"punct","subj":"T14929","obj":"T14926"},{"id":"R4456","pred":"appos","subj":"T14930","obj":"T14926"},{"id":"R4458","pred":"punct","subj":"T14931","obj":"T14923"},{"id":"R4463","pred":"punct","subj":"T14932","obj":"T14923"},{"id":"R4469","pred":"cc","subj":"T14933","obj":"T14923"},{"id":"R4473","pred":"compound","subj":"T14934","obj":"T14935"},{"id":"R4477","pred":"conj","subj":"T14935","obj":"T14923"},{"id":"R4481","pred":"punct","subj":"T14936","obj":"T14935"},{"id":"R4484","pred":"dep","subj":"T14937","obj":"T14938"},{"id":"R4489","pred":"relcl","subj":"T14938","obj":"T14935"},{"id":"R4492","pred":"prep","subj":"T14939","obj":"T14938"},{"id":"R4493","pred":"pobj","subj":"T14940","obj":"T14939"},{"id":"R4496","pred":"compound","subj":"T14941","obj":"T14942"},{"id":"R4500","pred":"dobj","subj":"T14942","obj":"T14938"},{"id":"R4503","pred":"prep","subj":"T14943","obj":"T14942"},{"id":"R4506","pred":"pobj","subj":"T14944","obj":"T14943"},{"id":"R4510","pred":"advcl","subj":"T14945","obj":"T14938"},{"id":"R4513","pred":"dobj","subj":"T14946","obj":"T14945"},{"id":"R4516","pred":"aux","subj":"T14947","obj":"T14948"},{"id":"R4518","pred":"xcomp","subj":"T14948","obj":"T14945"},{"id":"R4521","pred":"det","subj":"T14949","obj":"T14950"},{"id":"R4525","pred":"dobj","subj":"T14950","obj":"T14948"},{"id":"R4529","pred":"amod","subj":"T14951","obj":"T14950"},{"id":"R4532","pred":"punct","subj":"T14952","obj":"T14953"},{"id":"R4536","pred":"parataxis","subj":"T14953","obj":"T14938"},{"id":"R4539","pred":"punct","subj":"T14954","obj":"T14955"},{"id":"R4543","pred":"prep","subj":"T14955","obj":"T14953"},{"id":"R4547","pred":"punct","subj":"T14956","obj":"T14953"},{"id":"R4551","pred":"punct","subj":"T14957","obj":"T14884"}],"attributes":[{"subj":"T14882","pred":"source","obj":"craft-sa-dev"},{"subj":"T14883","pred":"source","obj":"craft-sa-dev"},{"subj":"T14884","pred":"source","obj":"craft-sa-dev"},{"subj":"T14885","pred":"source","obj":"craft-sa-dev"},{"subj":"T14886","pred":"source","obj":"craft-sa-dev"},{"subj":"T14887","pred":"source","obj":"craft-sa-dev"},{"subj":"T14888","pred":"source","obj":"craft-sa-dev"},{"subj":"T14889","pred":"source","obj":"craft-sa-dev"},{"subj":"T14890","pred":"source","obj":"craft-sa-dev"},{"subj":"T14891","pred":"source","obj":"craft-sa-dev"},{"subj":"T14892","pred":"source","obj":"craft-sa-dev"},{"subj":"T14893","pred":"source","obj":"craft-sa-dev"},{"subj":"T14894","pred":"source","obj":"craft-sa-dev"},{"subj":"T14895","pred":"source","obj":"craft-sa-dev"},{"subj":"T14896","pred":"source","obj":"craft-sa-dev"},{"subj":"T14897","pred":"source","obj":"craft-sa-dev"},{"subj":"T14898","pred":"source","obj":"craft-sa-dev"},{"subj":"T14899","pred":"source","obj":"craft-sa-dev"},{"subj":"T14900","pred":"source","obj":"craft-sa-dev"},{"subj":"T14901","pred":"source","obj":"craft-sa-dev"},{"subj":"T14902","pred":"source","obj":"craft-sa-dev"},{"subj":"T14903","pred":"source","obj":"craft-sa-dev"},{"subj":"T14904","pred":"source","obj":"craft-sa-dev"},{"subj":"T14905","pred":"source","obj":"craft-sa-dev"},{"subj":"T14906","pred":"source","obj":"craft-sa-dev"},{"subj":"T14907","pred":"source","obj":"craft-sa-dev"},{"subj":"T14908","pred":"source","obj":"craft-sa-dev"},{"subj":"T14909","pred":"source","obj":"craft-sa-dev"},{"subj":"T14910","pred":"source","obj":"craft-sa-dev"},{"subj":"T14911","pred":"source","obj":"craft-sa-dev"},{"subj":"T14912","pred":"source","obj":"craft-sa-dev"},{"subj":"T14913","pred":"source","obj":"craft-sa-dev"},{"subj":"T14914","pred":"source","obj":"craft-sa-dev"},{"subj":"T14915","pred":"source","obj":"craft-sa-dev"},{"subj":"T14916","pred":"source","obj":"craft-sa-dev"},{"subj":"T14917","pred":"source","obj":"craft-sa-dev"},{"subj":"T14918","pred":"source","obj":"craft-sa-dev"},{"subj":"T14919","pred":"source","obj":"craft-sa-dev"},{"subj":"T14920","pred":"source","obj":"craft-sa-dev"},{"subj":"T14921","pred":"source","obj":"craft-sa-dev"},{"subj":"T14922","pred":"source","obj":"craft-sa-dev"},{"subj":"T14923","pred":"source","obj":"craft-sa-dev"},{"subj":"T14924","pred":"source","obj":"craft-sa-dev"},{"subj":"T14925","pred":"source","obj":"craft-sa-dev"},{"subj":"T14926","pred":"source","obj":"craft-sa-dev"},{"subj":"T14927","pred":"source","obj":"craft-sa-dev"},{"subj":"T14928","pred":"source","obj":"craft-sa-dev"},{"subj":"T14929","pred":"source","obj":"craft-sa-dev"},{"subj":"T14930","pred":"source","obj":"craft-sa-dev"},{"subj":"T14931","pred":"source","obj":"craft-sa-dev"},{"subj":"T14932","pred":"source","obj":"craft-sa-dev"},{"subj":"T14933","pred":"source","obj":"craft-sa-dev"},{"subj":"T14934","pred":"source","obj":"craft-sa-dev"},{"subj":"T14935","pred":"source","obj":"craft-sa-dev"},{"subj":"T14936","pred":"source","obj":"craft-sa-dev"},{"subj":"T14937","pred":"source","obj":"craft-sa-dev"},{"subj":"T14938","pred":"source","obj":"craft-sa-dev"},{"subj":"T14939","pred":"source","obj":"craft-sa-dev"},{"subj":"T14940","pred":"source","obj":"craft-sa-dev"},{"subj":"T14941","pred":"source","obj":"craft-sa-dev"},{"subj":"T14942","pred":"source","obj":"craft-sa-dev"},{"subj":"T14943","pred":"source","obj":"craft-sa-dev"},{"subj":"T14944","pred":"source","obj":"craft-sa-dev"},{"subj":"T14945","pred":"source","obj":"craft-sa-dev"},{"subj":"T14946","pred":"source","obj":"craft-sa-dev"},{"subj":"T14947","pred":"source","obj":"craft-sa-dev"},{"subj":"T14948","pred":"source","obj":"craft-sa-dev"},{"subj":"T14949","pred":"source","obj":"craft-sa-dev"},{"subj":"T14950","pred":"source","obj":"craft-sa-dev"},{"subj":"T14951","pred":"source","obj":"craft-sa-dev"},{"subj":"T14952","pred":"source","obj":"craft-sa-dev"},{"subj":"T14953","pred":"source","obj":"craft-sa-dev"},{"subj":"T14954","pred":"source","obj":"craft-sa-dev"},{"subj":"T14955","pred":"source","obj":"craft-sa-dev"},{"subj":"T14956","pred":"source","obj":"craft-sa-dev"},{"subj":"T14957","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T13863","span":{"begin":15,"end":18},"obj":"CL_EXT:neural_crest_cell"},{"id":"T13864","span":{"begin":19,"end":24},"obj":"GO:0016265"},{"id":"T13865","span":{"begin":33,"end":37},"obj":"PR_EXT:000000047"},{"id":"T13866","span":{"begin":38,"end":45},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T13867","span":{"begin":74,"end":83},"obj":"GO_EXT:biological_movement_or_translocation_process"},{"id":"T13868","span":{"begin":98,"end":102},"obj":"CL_EXT:neural_crest_cell"},{"id":"T13869","span":{"begin":110,"end":115},"obj":"SO_EXT:0000704"},{"id":"T13870","span":{"begin":143,"end":147},"obj":"PR_EXT:000016143"},{"id":"T13871","span":{"begin":152,"end":156},"obj":"PR_EXT:000005883"},{"id":"T13872","span":{"begin":158,"end":165},"obj":"GO:0065007"},{"id":"T13873","span":{"begin":166,"end":169},"obj":"CL_EXT:neural_crest_cell"},{"id":"T13874","span":{"begin":202,"end":212},"obj":"GO:0065007"},{"id":"T13875","span":{"begin":213,"end":226},"obj":"GO:0008283"},{"id":"T13876","span":{"begin":234,"end":255},"obj":"UBERON:0009889"},{"id":"T13877","span":{"begin":257,"end":260},"obj":"UBERON:0009889"},{"id":"T13878","span":{"begin":267,"end":275},"obj":"UBERON:0000925"},{"id":"T13879","span":{"begin":330,"end":334},"obj":"CL_EXT:neural_crest_cell"},{"id":"T13880","span":{"begin":365,"end":375},"obj":"UBERON:0006562"}],"attributes":[{"subj":"T13863","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13864","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13865","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13866","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13867","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13868","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13869","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13870","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13871","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13872","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13873","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13874","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13875","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13876","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13877","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13878","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13879","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T13880","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T13615","span":{"begin":19,"end":24},"obj":"GO:0016265"},{"id":"T13616","span":{"begin":33,"end":37},"obj":"PR:000000047"},{"id":"T13617","span":{"begin":110,"end":115},"obj":"SO:0000704"},{"id":"T13618","span":{"begin":143,"end":147},"obj":"PR:000016143"},{"id":"T13619","span":{"begin":152,"end":156},"obj":"PR:000005883"},{"id":"T13620","span":{"begin":158,"end":165},"obj":"GO:0065007"},{"id":"T13621","span":{"begin":202,"end":212},"obj":"GO:0065007"},{"id":"T13622","span":{"begin":213,"end":226},"obj":"GO:0008283"},{"id":"T13623","span":{"begin":234,"end":255},"obj":"UBERON:0009889"},{"id":"T13624","span":{"begin":257,"end":260},"obj":"UBERON:0009889"},{"id":"T13625","span":{"begin":267,"end":275},"obj":"UBERON:0000925"},{"id":"T13626","span":{"begin":365,"end":375},"obj":"UBERON:0006562"}],"attributes":[{"subj":"T13615","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13616","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13617","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13618","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13619","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13620","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13621","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13622","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13623","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13624","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13625","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T13626","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#c4ec93","default":true},{"id":"craft-ca-core-ex-dev","color":"#ec93de"},{"id":"craft-ca-core-dev","color":"#93ecdf"}]}]}}