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PMC:1635039 / 26657-28390 JSONTXT

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Id Subject Object Predicate Lexical cue
T14626 0-7 JJ denotes Several
T14627 17-24 NNS denotes studies
T14628 8-10 FW denotes in
T14629 11-16 FW denotes vitro
T14630 30-39 VBN denotes suggested
T14631 25-29 VBP denotes have
T14632 40-42 DT denotes an
T14633 57-61 NN denotes role
T14634 43-56 JJ denotes indispensable
T14635 62-65 IN denotes for
T14636 66-69 NN denotes TGF
T14637 70-71 NN denotes β
T14638 69-70 HYPH denotes -
T14639 71-72 HYPH denotes -
T14640 72-81 VBG denotes signaling
T14641 82-84 IN denotes in
T14642 85-100 NN denotes differentiation
T14643 101-103 IN denotes of
T14644 104-108 NNS denotes NCCs
T14645 109-113 IN denotes into
T14646 114-120 JJ denotes smooth
T14647 121-127 NN denotes muscle
T14648 128-133 NNS denotes cells
T14649 133-134 . denotes .
T14650 134-358 sentence denotes Moreover, a recent in vivo study suggested that mice lacking Tgfbr2 in CNCCs display defective NCC differentiation into αSMA-positive cells in the AP septum [9], although this result was later disputed by another study [8].
T14651 135-143 RB denotes Moreover
T14652 168-177 VBD denotes suggested
T14653 143-145 , denotes ,
T14654 145-146 DT denotes a
T14655 162-167 NN denotes study
T14656 147-153 JJ denotes recent
T14657 154-156 FW denotes in
T14658 157-161 FW denotes vivo
T14659 178-182 IN denotes that
T14660 212-219 VBP denotes display
T14661 183-187 NNS denotes mice
T14662 188-195 VBG denotes lacking
T14663 196-202 NN denotes Tgfbr2
T14664 203-205 IN denotes in
T14665 206-211 NNS denotes CNCCs
T14666 220-229 JJ denotes defective
T14667 234-249 NN denotes differentiation
T14668 230-233 NN denotes NCC
T14669 250-254 IN denotes into
T14670 255-259 NN denotes αSMA
T14671 260-268 JJ denotes positive
T14672 259-260 HYPH denotes -
T14673 269-274 NNS denotes cells
T14674 275-277 IN denotes in
T14675 278-281 DT denotes the
T14676 285-291 NN denotes septum
T14677 282-284 NN denotes AP
T14678 292-293 -LRB- denotes [
T14679 293-294 CD denotes 9
T14680 294-295 -RRB- denotes ]
T14681 295-297 , denotes ,
T14682 297-305 IN denotes although
T14683 328-336 VBN denotes disputed
T14684 306-310 DT denotes this
T14685 311-317 NN denotes result
T14686 318-321 VBD denotes was
T14687 322-327 RB denotes later
T14688 337-339 IN denotes by
T14689 340-347 DT denotes another
T14690 348-353 NN denotes study
T14691 354-355 -LRB- denotes [
T14692 355-356 CD denotes 8
T14693 356-357 -RRB- denotes ]
T14694 357-358 . denotes .
T14695 358-520 sentence denotes Our immunohistochemical staining of αSMA in the OFT unequivocally demonstrated that signaling via ALK5 is not required for smooth muscle differentiation in vivo.
T14696 359-362 PRP$ denotes Our
T14697 383-391 NN denotes staining
T14698 363-382 JJ denotes immunohistochemical
T14699 425-437 VBD denotes demonstrated
T14700 392-394 IN denotes of
T14701 395-399 NN denotes αSMA
T14702 400-402 IN denotes in
T14703 403-406 DT denotes the
T14704 407-410 NN denotes OFT
T14705 411-424 RB denotes unequivocally
T14706 438-442 IN denotes that
T14707 469-477 VBN denotes required
T14708 443-452 NN denotes signaling
T14709 453-456 IN denotes via
T14710 457-461 NN denotes ALK5
T14711 462-464 VBZ denotes is
T14712 465-468 RB denotes not
T14713 478-481 IN denotes for
T14714 482-488 JJ denotes smooth
T14715 489-495 NN denotes muscle
T14716 496-511 NN denotes differentiation
T14717 512-514 FW denotes in
T14718 515-519 FW denotes vivo
T14719 519-520 . denotes .
T14720 520-800 sentence denotes Moreover, it has been suggested that deletion of Tgfbr2 in NCCs leads to other phenotypic features reminiscent of those seen in the velocardiofacial/DiGeorge syndrome (VCF/DGS) [9] caused by a deletion of the so called DiGeorge critical region (DGCR) on chromosome 22q11 [34,35].
T14721 521-529 RB denotes Moreover
T14722 543-552 VBN denotes suggested
T14723 529-531 , denotes ,
T14724 531-533 PRP denotes it
T14725 534-537 VBZ denotes has
T14726 538-542 VBN denotes been
T14727 553-557 IN denotes that
T14728 585-590 VBZ denotes leads
T14729 558-566 NN denotes deletion
T14730 567-569 IN denotes of
T14731 570-576 NN denotes Tgfbr2
T14732 577-579 IN denotes in
T14733 580-584 NNS denotes NCCs
T14734 591-593 IN denotes to
T14735 594-599 JJ denotes other
T14736 611-619 NNS denotes features
T14737 600-610 JJ denotes phenotypic
T14738 620-631 JJ denotes reminiscent
T14739 632-634 IN denotes of
T14740 635-640 DT denotes those
T14741 641-645 VBN denotes seen
T14742 646-648 IN denotes in
T14743 649-652 DT denotes the
T14744 679-687 NN denotes syndrome
T14745 653-669 JJ denotes velocardiofacial
T14746 670-678 NN denotes DiGeorge
T14747 669-670 HYPH denotes /
T14748 688-689 -LRB- denotes (
T14749 689-692 NN denotes VCF
T14750 693-696 NN denotes DGS
T14751 692-693 HYPH denotes /
T14752 696-697 -RRB- denotes )
T14753 698-699 -LRB- denotes [
T14754 699-700 CD denotes 9
T14755 700-701 -RRB- denotes ]
T14756 702-708 VBN denotes caused
T14757 709-711 IN denotes by
T14758 712-713 DT denotes a
T14759 714-722 NN denotes deletion
T14760 723-725 IN denotes of
T14761 726-729 DT denotes the
T14762 758-764 NN denotes region
T14763 730-732 RB denotes so
T14764 733-739 VBN denotes called
T14765 740-748 NNP denotes DiGeorge
T14766 749-757 JJ denotes critical
T14767 765-766 -LRB- denotes (
T14768 766-770 NN denotes DGCR
T14769 770-771 -RRB- denotes )
T14770 772-774 IN denotes on
T14771 775-785 NN denotes chromosome
T14772 786-791 NN denotes 22q11
T14773 792-793 -LRB- denotes [
T14774 796-798 CD denotes 35
T14775 793-795 CD denotes 34
T14776 795-796 , denotes ,
T14777 798-799 -RRB- denotes ]
T14778 799-800 . denotes .
T14779 800-1061 sentence denotes Our present results suggest that although many of the observed phenotypes seen in Alk5/Wnt1-Cre mutants superficially resemble those seen in VCF/DGS, a detailed examination shows that the NC-specific abrogation of Alk5 does not lead to VCF/DGS-like phenotypes.
T14780 801-804 PRP$ denotes Our
T14781 813-820 NNS denotes results
T14782 805-812 JJ denotes present
T14783 821-828 VBP denotes suggest
T14784 829-833 IN denotes that
T14785 974-979 VBZ denotes shows
T14786 834-842 IN denotes although
T14787 919-927 VBP denotes resemble
T14788 843-847 JJ denotes many
T14789 848-850 IN denotes of
T14790 851-854 DT denotes the
T14791 864-874 NNS denotes phenotypes
T14792 855-863 VBN denotes observed
T14793 875-879 VBN denotes seen
T14794 880-882 IN denotes in
T14795 883-887 NN denotes Alk5
T14796 893-896 NN denotes Cre
T14797 887-888 HYPH denotes /
T14798 888-892 NN denotes Wnt1
T14799 892-893 HYPH denotes -
T14800 897-904 NNS denotes mutants
T14801 905-918 RB denotes superficially
T14802 928-933 DT denotes those
T14803 934-938 VBN denotes seen
T14804 939-941 IN denotes in
T14805 942-945 NN denotes VCF
T14806 946-949 NN denotes DGS
T14807 945-946 HYPH denotes /
T14808 949-951 , denotes ,
T14809 951-952 DT denotes a
T14810 962-973 NN denotes examination
T14811 953-961 VBN denotes detailed
T14812 980-984 IN denotes that
T14813 1029-1033 VB denotes lead
T14814 985-988 DT denotes the
T14815 1001-1011 NN denotes abrogation
T14816 989-991 NN denotes NC
T14817 992-1000 JJ denotes specific
T14818 991-992 HYPH denotes -
T14819 1012-1014 IN denotes of
T14820 1015-1019 NN denotes Alk5
T14821 1020-1024 VBZ denotes does
T14822 1025-1028 RB denotes not
T14823 1034-1036 IN denotes to
T14824 1037-1040 NN denotes VCF
T14825 1041-1044 NN denotes DGS
T14826 1040-1041 HYPH denotes /
T14827 1045-1049 JJ denotes like
T14828 1044-1045 HYPH denotes -
T14829 1050-1060 NNS denotes phenotypes
T14830 1060-1061 . denotes .
T14831 1061-1342 sentence denotes Firstly, while the pharyngeal organ migration fails in Alk5/Wnt1-Cre mutants, perhaps as a result of increased mesenchymal cell death in the pharyngeal region, both the thymus, thyroid and parathyroid seem to develop relatively normally on the histological level in these mutants.
T14832 1062-1069 RB denotes Firstly
T14833 1263-1267 VBP denotes seem
T14834 1069-1071 , denotes ,
T14835 1071-1076 IN denotes while
T14836 1108-1113 VBZ denotes fails
T14837 1077-1080 DT denotes the
T14838 1098-1107 NN denotes migration
T14839 1081-1091 JJ denotes pharyngeal
T14840 1092-1097 NN denotes organ
T14841 1114-1116 IN denotes in
T14842 1117-1121 NN denotes Alk5
T14843 1127-1130 NN denotes Cre
T14844 1121-1122 HYPH denotes /
T14845 1122-1126 NN denotes Wnt1
T14846 1126-1127 HYPH denotes -
T14847 1131-1138 NNS denotes mutants
T14848 1138-1140 , denotes ,
T14849 1140-1147 RB denotes perhaps
T14850 1148-1150 IN denotes as
T14851 1151-1152 DT denotes a
T14852 1153-1159 NN denotes result
T14853 1160-1162 IN denotes of
T14854 1163-1172 VBN denotes increased
T14855 1190-1195 NN denotes death
T14856 1173-1184 JJ denotes mesenchymal
T14857 1185-1189 NN denotes cell
T14858 1196-1198 IN denotes in
T14859 1199-1202 DT denotes the
T14860 1214-1220 NN denotes region
T14861 1203-1213 JJ denotes pharyngeal
T14862 1220-1222 , denotes ,
T14863 1222-1226 CC denotes both
T14864 1231-1237 NN denotes thymus
T14865 1227-1230 DT denotes the
T14866 1237-1239 , denotes ,
T14867 1239-1246 NN denotes thyroid
T14868 1247-1250 CC denotes and
T14869 1251-1262 NN denotes parathyroid
T14870 1268-1270 TO denotes to
T14871 1271-1278 VB denotes develop
T14872 1279-1289 RB denotes relatively
T14873 1290-1298 RB denotes normally
T14874 1299-1301 IN denotes on
T14875 1302-1305 DT denotes the
T14876 1319-1324 NN denotes level
T14877 1306-1318 JJ denotes histological
T14878 1325-1327 IN denotes in
T14879 1328-1333 DT denotes these
T14880 1334-1341 NNS denotes mutants
T14881 1341-1342 . denotes .
T14882 1342-1733 sentence denotes Secondly, the NCC death seen in Alk5 mutants affects a predominantly postmigratory population of NCCs, while genes located in the DGCR, i.e., Tbx1 and CrkL, control NCC survival earlier at E8.5-E10 by regulating proliferation of the secondary heart field (SHF), and endoderm expansion, which in turn provides survival signal for NCCs allowing them to populate the pharyngeal region [36-39].
T14883 1343-1351 RB denotes Secondly
T14884 1388-1395 VBZ denotes affects
T14885 1351-1353 , denotes ,
T14886 1353-1356 DT denotes the
T14887 1361-1366 NN denotes death
T14888 1357-1360 NN denotes NCC
T14889 1367-1371 VBN denotes seen
T14890 1372-1374 IN denotes in
T14891 1375-1379 NN denotes Alk5
T14892 1380-1387 NNS denotes mutants
T14893 1396-1397 DT denotes a
T14894 1426-1436 NN denotes population
T14895 1398-1411 RB denotes predominantly
T14896 1412-1425 JJ denotes postmigratory
T14897 1437-1439 IN denotes of
T14898 1440-1444 NNS denotes NCCs
T14899 1444-1446 , denotes ,
T14900 1446-1451 IN denotes while
T14901 1500-1507 VBP denotes control
T14902 1452-1457 NNS denotes genes
T14903 1458-1465 VBN denotes located
T14904 1466-1468 IN denotes in
T14905 1469-1472 DT denotes the
T14906 1473-1477 NN denotes DGCR
T14907 1477-1479 , denotes ,
T14908 1479-1483 FW denotes i.e.
T14909 1485-1489 NN denotes Tbx1
T14910 1483-1485 , denotes ,
T14911 1490-1493 CC denotes and
T14912 1494-1498 NN denotes CrkL
T14913 1498-1500 , denotes ,
T14914 1508-1511 NN denotes NCC
T14915 1512-1520 NN denotes survival
T14916 1521-1528 RB denotes earlier
T14917 1529-1531 IN denotes at
T14918 1532-1536 NN denotes E8.5
T14919 1536-1537 SYM denotes -
T14920 1537-1540 NN denotes E10
T14921 1541-1543 IN denotes by
T14922 1544-1554 VBG denotes regulating
T14923 1555-1568 NN denotes proliferation
T14924 1569-1571 IN denotes of
T14925 1572-1575 DT denotes the
T14926 1592-1597 NN denotes field
T14927 1576-1585 JJ denotes secondary
T14928 1586-1591 NN denotes heart
T14929 1598-1599 -LRB- denotes (
T14930 1599-1602 NN denotes SHF
T14931 1602-1603 -RRB- denotes )
T14932 1603-1605 , denotes ,
T14933 1605-1608 CC denotes and
T14934 1609-1617 NN denotes endoderm
T14935 1618-1627 NN denotes expansion
T14936 1627-1629 , denotes ,
T14937 1629-1634 WDT denotes which
T14938 1643-1651 VBZ denotes provides
T14939 1635-1637 IN denotes in
T14940 1638-1642 NN denotes turn
T14941 1652-1660 NN denotes survival
T14942 1661-1667 NN denotes signal
T14943 1668-1671 IN denotes for
T14944 1672-1676 NNS denotes NCCs
T14945 1677-1685 VBG denotes allowing
T14946 1686-1690 PRP denotes them
T14947 1691-1693 TO denotes to
T14948 1694-1702 VB denotes populate
T14949 1703-1706 DT denotes the
T14950 1718-1724 NN denotes region
T14951 1707-1717 JJ denotes pharyngeal
T14952 1725-1726 -LRB- denotes [
T14953 1726-1728 CD denotes 36
T14954 1728-1729 SYM denotes -
T14955 1729-1731 CD denotes 39
T14956 1731-1732 -RRB- denotes ]
T14957 1732-1733 . denotes .
R4091 T14678 T14679 punct [,9
R4093 T14679 T14652 parataxis 9,suggested
R4094 T14680 T14679 punct ],9
R4096 T14681 T14652 punct ", ",suggested
R4097 T14682 T14683 mark although,disputed
R4099 T14683 T14652 advcl disputed,suggested
R4100 T14684 T14685 det this,result
R4101 T14685 T14683 nsubjpass result,disputed
R4103 T14686 T14683 auxpass was,disputed
R4104 T14687 T14683 advmod later,disputed
R4105 T14688 T14683 agent by,disputed
R4106 T14689 T14690 det another,study
R4107 T14690 T14688 pobj study,by
R4109 T14691 T14692 punct [,8
R4110 T14692 T14683 parataxis 8,disputed
R4111 T14693 T14692 punct ],8
R4113 T14694 T14652 punct .,suggested
R4115 T14696 T14697 poss Our,staining
R4116 T14697 T14699 nsubj staining,demonstrated
R4117 T14698 T14697 amod immunohistochemical,staining
R4119 T14700 T14697 prep of,staining
R4121 T14701 T14700 pobj αSMA,of
R4122 T14702 T14697 prep in,staining
R4123 T14703 T14704 det the,OFT
R4125 T14704 T14702 pobj OFT,in
R4127 T14705 T14699 advmod unequivocally,demonstrated
R4128 T14706 T14707 mark that,required
R4129 T14707 T14699 ccomp required,demonstrated
R4131 T14708 T14707 nsubjpass signaling,required
R4132 T14709 T14708 prep via,signaling
R4133 T14710 T14709 pobj ALK5,via
R4135 T14711 T14707 auxpass is,required
R4136 T14712 T14707 neg not,required
R4138 T14713 T14707 prep for,required
R4139 T14714 T14715 amod smooth,muscle
R4140 T14715 T14716 compound muscle,differentiation
R4142 T14716 T14713 pobj differentiation,for
R4143 T14717 T14718 advmod in,vivo
R4145 T14718 T14707 advmod vivo,required
R4146 T14719 T14699 punct .,demonstrated
R4147 T14626 T14627 amod Several,studies
R4148 T14721 T14722 advmod Moreover,suggested
R4149 T14723 T14722 punct ", ",suggested
R4150 T14627 T14630 nsubj studies,suggested
R4151 T14724 T14722 nsubjpass it,suggested
R4152 T14725 T14722 aux has,suggested
R4153 T14726 T14722 auxpass been,suggested
R4154 T14628 T14629 advmod in,vitro
R4155 T14727 T14728 mark that,leads
R4156 T14728 T14722 ccomp leads,suggested
R4157 T14729 T14728 nsubj deletion,leads
R4158 T14730 T14729 prep of,deletion
R4159 T14731 T14730 pobj Tgfbr2,of
R4160 T14732 T14729 prep in,deletion
R4161 T14629 T14627 amod vitro,studies
R4162 T14733 T14732 pobj NCCs,in
R4163 T14734 T14728 prep to,leads
R4164 T14735 T14736 amod other,features
R4165 T14631 T14630 aux have,suggested
R4166 T14736 T14734 pobj features,to
R4167 T14737 T14736 amod phenotypic,features
R4168 T14738 T14736 amod reminiscent,features
R4169 T14739 T14738 prep of,reminiscent
R4170 T14632 T14633 det an,role
R4171 T14740 T14739 pobj those,of
R4172 T14741 T14740 acl seen,those
R4173 T14742 T14741 prep in,seen
R4174 T14633 T14630 dobj role,suggested
R4175 T14743 T14744 det the,syndrome
R4176 T14634 T14633 amod indispensable,role
R4177 T14744 T14742 pobj syndrome,in
R4178 T14635 T14633 prep for,role
R4179 T14745 T14746 amod velocardiofacial,DiGeorge
R4180 T14746 T14744 compound DiGeorge,syndrome
R4181 T14747 T14746 punct /,DiGeorge
R4182 T14636 T14637 compound TGF,β
R4183 T14748 T14744 punct (,syndrome
R4184 T14749 T14750 compound VCF,DGS
R4185 T14637 T14635 pobj β,for
R4186 T14750 T14744 appos DGS,syndrome
R4187 T14751 T14750 punct /,DGS
R4188 T14752 T14741 punct ),seen
R4189 T14638 T14637 punct -,β
R4190 T14753 T14754 punct [,9
R4191 T14754 T14741 parataxis 9,seen
R4192 T14639 T14637 punct -,β
R4193 T14755 T14754 punct ],9
R4194 T14756 T14736 acl caused,features
R4195 T14640 T14637 amod signaling,β
R4196 T14757 T14756 agent by,caused
R4197 T14758 T14759 det a,deletion
R4198 T14759 T14757 pobj deletion,by
R4199 T14641 T14633 prep in,role
R4200 T14760 T14759 prep of,deletion
R4201 T14761 T14762 det the,region
R4202 T14642 T14641 pobj differentiation,in
R4203 T14762 T14760 pobj region,of
R4204 T14763 T14764 advmod so,called
R4205 T14643 T14642 prep of,differentiation
R4206 T14764 T14762 amod called,region
R4207 T14765 T14762 nmod DiGeorge,region
R4208 T14766 T14762 amod critical,region
R4209 T14767 T14762 punct (,region
R4210 T14768 T14762 appos DGCR,region
R4211 T14769 T14759 punct ),deletion
R4212 T14644 T14643 pobj NCCs,of
R4213 T14770 T14759 prep on,deletion
R4214 T14771 T14772 compound chromosome,22q11
R4215 T14645 T14644 prep into,NCCs
R4216 T14772 T14770 pobj 22q11,on
R4217 T14773 T14774 punct [,35
R4218 T14774 T14722 parataxis 35,suggested
R4219 T14646 T14647 amod smooth,muscle
R4220 T14775 T14774 nummod 34,35
R4221 T14776 T14774 punct ",",35
R4222 T14647 T14648 compound muscle,cells
R4223 T14777 T14774 punct ],35
R4224 T14778 T14722 punct .,suggested
R4225 T14648 T14645 pobj cells,into
R4226 T14780 T14781 poss Our,results
R4227 T14781 T14783 nsubj results,suggest
R4228 T14649 T14630 punct .,suggested
R4229 T14782 T14781 amod present,results
R4230 T14651 T14652 advmod Moreover,suggested
R4231 T14653 T14652 punct ", ",suggested
R4232 T14784 T14785 mark that,shows
R4233 T14654 T14655 det a,study
R4234 T14785 T14783 ccomp shows,suggest
R4235 T14786 T14787 mark although,resemble
R4236 T14655 T14652 nsubj study,suggested
R4237 T14787 T14785 advcl resemble,shows
R4238 T14788 T14787 nsubj many,resemble
R4239 T14789 T14788 prep of,many
R4240 T14656 T14655 amod recent,study
R4241 T14790 T14791 det the,phenotypes
R4242 T14791 T14789 pobj phenotypes,of
R4243 T14792 T14791 amod observed,phenotypes
R4244 T14657 T14658 advmod in,vivo
R4245 T14793 T14788 acl seen,many
R4246 T14794 T14793 prep in,seen
R4247 T14658 T14655 amod vivo,study
R4248 T14795 T14796 compound Alk5,Cre
R4249 T14796 T14800 compound Cre,mutants
R4250 T14797 T14796 punct /,Cre
R4251 T14659 T14660 mark that,display
R4252 T14798 T14796 compound Wnt1,Cre
R4253 T14799 T14796 punct -,Cre
R4254 T14800 T14794 pobj mutants,in
R4255 T14660 T14652 ccomp display,suggested
R4256 T14801 T14787 advmod superficially,resemble
R4257 T14802 T14787 dobj those,resemble
R4258 T14661 T14660 nsubj mice,display
R4259 T14803 T14802 acl seen,those
R4260 T14804 T14803 prep in,seen
R4261 T14805 T14806 compound VCF,DGS
R4262 T14806 T14804 pobj DGS,in
R4263 T14807 T14806 punct /,DGS
R4264 T14808 T14785 punct ", ",shows
R4265 T14662 T14661 acl lacking,mice
R4266 T14809 T14810 det a,examination
R4267 T14810 T14785 nsubj examination,shows
R4268 T14663 T14662 dobj Tgfbr2,lacking
R4269 T14811 T14810 amod detailed,examination
R4270 T14812 T14813 mark that,lead
R4271 T14664 T14663 prep in,Tgfbr2
R4272 T14813 T14785 ccomp lead,shows
R4273 T14814 T14815 det the,abrogation
R4274 T14815 T14813 nsubj abrogation,lead
R4275 T14665 T14664 pobj CNCCs,in
R4276 T14816 T14817 npadvmod NC,specific
R4277 T14817 T14815 amod specific,abrogation
R4278 T14666 T14667 amod defective,differentiation
R4279 T14818 T14817 punct -,specific
R4280 T14819 T14815 prep of,abrogation
R4281 T14820 T14819 pobj Alk5,of
R4282 T14667 T14660 dobj differentiation,display
R4283 T14821 T14813 aux does,lead
R4284 T14822 T14813 neg not,lead
R4285 T14823 T14813 prep to,lead
R4286 T14668 T14667 compound NCC,differentiation
R4287 T14824 T14825 compound VCF,DGS
R4288 T14825 T14827 npadvmod DGS,like
R4289 T14669 T14660 prep into,display
R4290 T14826 T14825 punct /,DGS
R4291 T14827 T14829 amod like,phenotypes
R4292 T14670 T14671 npadvmod αSMA,positive
R4293 T14828 T14827 punct -,like
R4294 T14671 T14673 amod positive,cells
R4295 T14829 T14823 pobj phenotypes,to
R4296 T14672 T14671 punct -,positive
R4297 T14830 T14783 punct .,suggest
R4298 T14673 T14669 pobj cells,into
R4299 T14832 T14833 advmod Firstly,seem
R4300 T14674 T14660 prep in,display
R4301 T14834 T14833 punct ", ",seem
R4302 T14835 T14836 mark while,fails
R4303 T14675 T14676 det the,septum
R4304 T14836 T14833 advcl fails,seem
R4305 T14837 T14838 det the,migration
R4306 T14838 T14836 nsubj migration,fails
R4307 T14676 T14674 pobj septum,in
R4308 T14839 T14840 amod pharyngeal,organ
R4309 T14840 T14838 compound organ,migration
R4310 T14841 T14836 prep in,fails
R4311 T14842 T14843 compound Alk5,Cre
R4312 T14843 T14847 compound Cre,mutants
R4313 T14844 T14843 punct /,Cre
R4314 T14677 T14676 compound AP,septum
R4315 T14845 T14843 compound Wnt1,Cre
R4316 T14846 T14843 punct -,Cre
R4317 T14847 T14841 pobj mutants,in
R4318 T14889 T14887 acl seen,death
R4319 T14848 T14836 punct ", ",fails
R4320 T14849 T14850 advmod perhaps,as
R4321 T14850 T14836 prep as,fails
R4322 T14890 T14889 prep in,seen
R4323 T14851 T14852 det a,result
R4324 T14852 T14850 pobj result,as
R4325 T14853 T14852 prep of,result
R4326 T14891 T14892 compound Alk5,mutants
R4327 T14854 T14855 amod increased,death
R4328 T14855 T14853 pobj death,of
R4329 T14856 T14857 amod mesenchymal,cell
R4330 T14892 T14890 pobj mutants,in
R4331 T14857 T14855 compound cell,death
R4332 T14858 T14855 prep in,death
R4333 T14859 T14860 det the,region
R4334 T14893 T14894 det a,population
R4335 T14860 T14858 pobj region,in
R4336 T14861 T14860 amod pharyngeal,region
R4337 T14894 T14884 dobj population,affects
R4338 T14862 T14833 punct ", ",seem
R4339 T14863 T14864 preconj both,thymus
R4340 T14864 T14833 nsubj thymus,seem
R4341 T14895 T14896 advmod predominantly,postmigratory
R4342 T14865 T14864 det the,thymus
R4343 T14866 T14864 punct ", ",thymus
R4344 T14867 T14864 conj thyroid,thymus
R4345 T14896 T14894 amod postmigratory,population
R4346 T14868 T14867 cc and,thyroid
R4347 T14869 T14867 conj parathyroid,thyroid
R4348 T14897 T14894 prep of,population
R4349 T14870 T14871 aux to,develop
R4350 T14871 T14833 xcomp develop,seem
R4351 T14872 T14873 advmod relatively,normally
R4352 T14898 T14897 pobj NCCs,of
R4353 T14873 T14871 advmod normally,develop
R4354 T14874 T14871 prep on,develop
R4355 T14875 T14876 det the,level
R4356 T14899 T14884 punct ", ",affects
R4357 T14876 T14874 pobj level,on
R4358 T14877 T14876 amod histological,level
R4359 T14878 T14871 prep in,develop
R4360 T14900 T14901 mark while,control
R4361 T14879 T14880 det these,mutants
R4362 T14880 T14878 pobj mutants,in
R4363 T14881 T14833 punct .,seem
R4364 T14883 T14884 advmod Secondly,affects
R4365 T14901 T14884 advcl control,affects
R4366 T14885 T14884 punct ", ",affects
R4367 T14886 T14887 det the,death
R4368 T14902 T14901 nsubj genes,control
R4369 T14887 T14884 nsubj death,affects
R4370 T14888 T14887 compound NCC,death
R4371 T14903 T14902 acl located,genes
R4372 T14904 T14903 prep in,located
R4373 T14905 T14906 det the,DGCR
R4376 T14906 T14904 pobj DGCR,in
R4380 T14907 T14906 punct ", ",DGCR
R4381 T14908 T14909 advmod i.e.,Tbx1
R4384 T14909 T14906 appos Tbx1,DGCR
R4387 T14910 T14909 punct ", ",Tbx1
R4391 T14911 T14909 cc and,Tbx1
R4394 T14912 T14909 conj CrkL,Tbx1
R4397 T14913 T14901 punct ", ",control
R4400 T14914 T14915 compound NCC,survival
R4401 T14915 T14901 dobj survival,control
R4402 T14916 T14901 advmod earlier,control
R4405 T14917 T14901 prep at,control
R4408 T14918 T14917 pobj E8.5,at
R4412 T14919 T14920 punct -,E10
R4419 T14920 T14918 prep E10,E8.5
R4423 T14921 T14901 prep by,control
R4427 T14922 T14921 pcomp regulating,by
R4430 T14923 T14922 dobj proliferation,regulating
R4433 T14924 T14923 prep of,proliferation
R4438 T14925 T14926 det the,field
R4442 T14926 T14924 pobj field,of
R4445 T14927 T14926 amod secondary,field
R4448 T14928 T14926 compound heart,field
R4452 T14929 T14926 punct (,field
R4456 T14930 T14926 appos SHF,field
R4458 T14931 T14923 punct ),proliferation
R4463 T14932 T14923 punct ", ",proliferation
R4469 T14933 T14923 cc and,proliferation
R4473 T14934 T14935 compound endoderm,expansion
R4477 T14935 T14923 conj expansion,proliferation
R4481 T14936 T14935 punct ", ",expansion
R4484 T14937 T14938 dep which,provides
R4489 T14938 T14935 relcl provides,expansion
R4492 T14939 T14938 prep in,provides
R4493 T14940 T14939 pobj turn,in
R4496 T14941 T14942 compound survival,signal
R4500 T14942 T14938 dobj signal,provides
R4503 T14943 T14942 prep for,signal
R4506 T14944 T14943 pobj NCCs,for
R4510 T14945 T14938 advcl allowing,provides
R4513 T14946 T14945 dobj them,allowing
R4516 T14947 T14948 aux to,populate
R4518 T14948 T14945 xcomp populate,allowing
R4521 T14949 T14950 det the,region
R4525 T14950 T14948 dobj region,populate
R4529 T14951 T14950 amod pharyngeal,region
R4532 T14952 T14953 punct [,36
R4536 T14953 T14938 parataxis 36,provides
R4539 T14954 T14955 punct -,39
R4543 T14955 T14953 prep 39,36
R4547 T14956 T14953 punct ],36
R4551 T14957 T14884 punct .,affects

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13814 66-71 PR_EXT:000000046 denotes TGF-β
T13815 66-81 GO:0007179 denotes TGF-β-signaling
T13816 85-100 _FRAGMENT denotes differentiation
T13817 109-133 GO:0051145 denotes into smooth muscle cells
T13818 104-108 CL_EXT:neural_crest_cell denotes NCCs
T13819 114-127 UBERON:0001135 denotes smooth muscle
T13820 114-133 CL:0000192 denotes smooth muscle cells
T13821 128-133 CL_GO_EXT:cell denotes cells
T13822 183-187 NCBITaxon:10088 denotes mice
T13824 196-202 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T13825 230-233 CL_EXT:neural_crest_cell denotes NCC
T13826 234-254 _FRAGMENT denotes differentiation into
T13827 269-274 GO:0030154 denotes cells
T13828 255-259 PR_EXT:000003675 denotes αSMA
T13829 269-274 CL_GO_EXT:cell denotes cells
T13830 282-291 UBERON:0006207 denotes AP septum
T13831 395-399 PR_EXT:000003675 denotes αSMA
T13832 407-410 UBERON:0004145 denotes OFT
T13833 443-452 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T13834 457-461 PR_EXT:000000047 denotes ALK5
T13835 482-495 UBERON:0001135 denotes smooth muscle
T13836 496-511 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T13837 558-566 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T13838 570-576 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T13839 580-584 CL_EXT:neural_crest_cell denotes NCCs
T13840 714-722 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T13841 758-764 _FRAGMENT denotes region
T13842 772-785 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes on chromosome
T13843 883-887 PR_EXT:000000047 denotes Alk5
T13844 888-892 PR_EXT:000017435 denotes Wnt1
T13845 897-904 SO_EXT:sequence_altered_entity denotes mutants
T13846 989-991 UBERON:0002342 denotes NC
T13847 1015-1019 PR_EXT:000000047 denotes Alk5
T13848 1081-1091 UBERON:0006562 denotes pharyngeal
T13849 1092-1097 UBERON:0000062 denotes organ
T13850 1098-1107 GO_EXT:biological_movement_or_translocation_process denotes migration
T13851 1117-1121 PR_EXT:000000047 denotes Alk5
T13852 1122-1126 PR_EXT:000017435 denotes Wnt1
T13853 1131-1138 SO_EXT:sequence_altered_entity denotes mutants
T13854 1173-1184 UBERON:0003104 denotes mesenchymal
T13855 1173-1189 CL:0000134 denotes mesenchymal cell
T13856 1185-1189 CL_GO_EXT:cell denotes cell
T13857 1185-1195 GO:0008219 denotes cell death
T13858 1203-1213 UBERON:0006562 denotes pharyngeal
T13859 1231-1237 UBERON:0002370 denotes thymus
T13860 1239-1246 UBERON:0002046 denotes thyroid
T13861 1251-1262 UBERON:0001132 denotes parathyroid
T13862 1334-1341 SO_EXT:sequence_altered_entity denotes mutants
T13863 1357-1360 CL_EXT:neural_crest_cell denotes NCC
T13864 1361-1366 GO:0016265 denotes death
T13865 1375-1379 PR_EXT:000000047 denotes Alk5
T13866 1380-1387 SO_EXT:sequence_altered_entity denotes mutants
T13867 1416-1425 GO_EXT:biological_movement_or_translocation_process denotes migratory
T13868 1440-1444 CL_EXT:neural_crest_cell denotes NCCs
T13869 1452-1457 SO_EXT:0000704 denotes genes
T13870 1485-1489 PR_EXT:000016143 denotes Tbx1
T13871 1494-1498 PR_EXT:000005883 denotes CrkL
T13872 1500-1507 GO:0065007 denotes control
T13873 1508-1511 CL_EXT:neural_crest_cell denotes NCC
T13874 1544-1554 GO:0065007 denotes regulating
T13875 1555-1568 GO:0008283 denotes proliferation
T13876 1576-1597 UBERON:0009889 denotes secondary heart field
T13877 1599-1602 UBERON:0009889 denotes SHF
T13878 1609-1617 UBERON:0000925 denotes endoderm
T13879 1672-1676 CL_EXT:neural_crest_cell denotes NCCs
T13880 1707-1717 UBERON:0006562 denotes pharyngeal
R3448 T13817 T13816 _lexicallyChainedTo into smooth muscle cells,differentiation
R3449 T13827 T13826 _lexicallyChainedTo cells,differentiation into
R3450 T13842 T13841 _lexicallyChainedTo on chromosome,region

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13585 66-71 PR:000000046 denotes TGF-β
T13586 66-81 GO:0007179 denotes TGF-β-signaling
T13587 85-100 _FRAGMENT denotes differentiation
T13588 109-133 GO:0051145 denotes into smooth muscle cells
T13589 114-127 UBERON:0001135 denotes smooth muscle
T13590 114-133 CL:0000192 denotes smooth muscle cells
T13591 183-187 NCBITaxon:10088 denotes mice
T13592 234-254 _FRAGMENT denotes differentiation into
T13593 269-274 GO:0030154 denotes cells
T13594 255-259 PR:000003675 denotes αSMA
T13595 282-291 UBERON:0006207 denotes AP septum
T13596 395-399 PR:000003675 denotes αSMA
T13597 407-410 UBERON:0004145 denotes OFT
T13598 457-461 PR:000000047 denotes ALK5
T13599 482-495 UBERON:0001135 denotes smooth muscle
T13600 883-887 PR:000000047 denotes Alk5
T13601 888-892 PR:000017435 denotes Wnt1
T13602 989-991 UBERON:0002342 denotes NC
T13603 1015-1019 PR:000000047 denotes Alk5
T13604 1081-1091 UBERON:0006562 denotes pharyngeal
T13605 1092-1097 UBERON:0000062 denotes organ
T13606 1117-1121 PR:000000047 denotes Alk5
T13607 1122-1126 PR:000017435 denotes Wnt1
T13608 1173-1184 UBERON:0003104 denotes mesenchymal
T13609 1173-1189 CL:0000134 denotes mesenchymal cell
T13610 1185-1195 GO:0008219 denotes cell death
T13611 1203-1213 UBERON:0006562 denotes pharyngeal
T13612 1231-1237 UBERON:0002370 denotes thymus
T13613 1239-1246 UBERON:0002046 denotes thyroid
T13614 1251-1262 UBERON:0001132 denotes parathyroid
T13615 1361-1366 GO:0016265 denotes death
T13616 1375-1379 PR:000000047 denotes Alk5
T13617 1452-1457 SO:0000704 denotes genes
T13618 1485-1489 PR:000016143 denotes Tbx1
T13619 1494-1498 PR:000005883 denotes CrkL
T13620 1500-1507 GO:0065007 denotes control
T13621 1544-1554 GO:0065007 denotes regulating
T13622 1555-1568 GO:0008283 denotes proliferation
T13623 1576-1597 UBERON:0009889 denotes secondary heart field
T13624 1599-1602 UBERON:0009889 denotes SHF
T13625 1609-1617 UBERON:0000925 denotes endoderm
T13626 1707-1717 UBERON:0006562 denotes pharyngeal
R3438 T13588 T13587 _lexicallyChainedTo into smooth muscle cells,differentiation
R3439 T13593 T13592 _lexicallyChainedTo cells,differentiation into