Id |
Subject |
Object |
Predicate |
Lexical cue |
T13939 |
0-6 |
IN |
denotes |
During |
T13940 |
66-72 |
VBN |
denotes |
proven |
T13941 |
7-10 |
DT |
denotes |
the |
T13942 |
20-25 |
NNS |
denotes |
years |
T13943 |
11-15 |
JJ |
denotes |
last |
T13944 |
16-19 |
JJ |
denotes |
few |
T13945 |
26-29 |
DT |
denotes |
the |
T13946 |
57-61 |
NN |
denotes |
line |
T13947 |
30-34 |
NN |
denotes |
Wnt1 |
T13948 |
35-38 |
NN |
denotes |
Cre |
T13949 |
34-35 |
HYPH |
denotes |
- |
T13950 |
39-49 |
JJ |
denotes |
transgenic |
T13951 |
50-56 |
NN |
denotes |
driver |
T13952 |
62-65 |
VBZ |
denotes |
has |
T13953 |
73-75 |
TO |
denotes |
to |
T13954 |
76-78 |
VB |
denotes |
be |
T13955 |
79-80 |
DT |
denotes |
a |
T13956 |
90-94 |
NN |
denotes |
tool |
T13957 |
81-89 |
JJ |
denotes |
powerful |
T13958 |
95-98 |
IN |
denotes |
for |
T13959 |
99-105 |
NN |
denotes |
tissue |
T13960 |
106-114 |
JJ |
denotes |
specific |
T13961 |
105-106 |
HYPH |
denotes |
- |
T13962 |
120-128 |
NN |
denotes |
deletion |
T13963 |
115-119 |
NN |
denotes |
gene |
T13964 |
129-131 |
IN |
denotes |
in |
T13965 |
132-136 |
NNS |
denotes |
NCCs |
T13966 |
137-138 |
-LRB- |
denotes |
[ |
T13967 |
147-149 |
CD |
denotes |
28 |
T13968 |
138-140 |
CD |
denotes |
12 |
T13969 |
140-141 |
, |
denotes |
, |
T13970 |
141-143 |
CD |
denotes |
13 |
T13971 |
143-144 |
, |
denotes |
, |
T13972 |
144-146 |
CD |
denotes |
27 |
T13973 |
146-147 |
, |
denotes |
, |
T13974 |
149-150 |
-RRB- |
denotes |
] |
T13975 |
150-151 |
. |
denotes |
. |
T13976 |
151-340 |
sentence |
denotes |
Using this approach, several studies have independently shown that the NC-specific deletion of the Tgfbr2 gene leads to a distinct set of calvarial, facial and cardiac defects [8,9,20,29]. |
T13977 |
152-157 |
VBG |
denotes |
Using |
T13978 |
208-213 |
VBN |
denotes |
shown |
T13979 |
158-162 |
DT |
denotes |
this |
T13980 |
163-171 |
NN |
denotes |
approach |
T13981 |
171-173 |
, |
denotes |
, |
T13982 |
173-180 |
JJ |
denotes |
several |
T13983 |
181-188 |
NNS |
denotes |
studies |
T13984 |
189-193 |
VBP |
denotes |
have |
T13985 |
194-207 |
RB |
denotes |
independently |
T13986 |
214-218 |
IN |
denotes |
that |
T13987 |
263-268 |
VBZ |
denotes |
leads |
T13988 |
219-222 |
DT |
denotes |
the |
T13989 |
235-243 |
NN |
denotes |
deletion |
T13990 |
223-225 |
NN |
denotes |
NC |
T13991 |
226-234 |
JJ |
denotes |
specific |
T13992 |
225-226 |
HYPH |
denotes |
- |
T13993 |
244-246 |
IN |
denotes |
of |
T13994 |
247-250 |
DT |
denotes |
the |
T13995 |
258-262 |
NN |
denotes |
gene |
T13996 |
251-257 |
NN |
denotes |
Tgfbr2 |
T13997 |
269-271 |
IN |
denotes |
to |
T13998 |
272-273 |
DT |
denotes |
a |
T13999 |
283-286 |
NN |
denotes |
set |
T14000 |
274-282 |
JJ |
denotes |
distinct |
T14001 |
287-289 |
IN |
denotes |
of |
T14002 |
290-299 |
JJ |
denotes |
calvarial |
T14003 |
320-327 |
NNS |
denotes |
defects |
T14004 |
299-301 |
, |
denotes |
, |
T14005 |
301-307 |
JJ |
denotes |
facial |
T14006 |
308-311 |
CC |
denotes |
and |
T14007 |
312-319 |
JJ |
denotes |
cardiac |
T14008 |
328-329 |
-LRB- |
denotes |
[ |
T14009 |
336-338 |
CD |
denotes |
29 |
T14010 |
329-330 |
CD |
denotes |
8 |
T14011 |
330-331 |
, |
denotes |
, |
T14012 |
331-332 |
CD |
denotes |
9 |
T14013 |
332-333 |
, |
denotes |
, |
T14014 |
333-335 |
CD |
denotes |
20 |
T14015 |
335-336 |
, |
denotes |
, |
T14016 |
338-339 |
-RRB- |
denotes |
] |
T14017 |
339-340 |
. |
denotes |
. |
T14018 |
340-627 |
sentence |
denotes |
Interestingly, these defects appear quite different both in the craniofacial and pharyngeal regions, including the heart, when compared to the corresponding mutants of Alk5, which encodes the TGF-β type I receptor, a prototypical binding partner of TGF-βRII [19] and the present study). |
T14019 |
341-354 |
RB |
denotes |
Interestingly |
T14020 |
370-376 |
VBP |
denotes |
appear |
T14021 |
354-356 |
, |
denotes |
, |
T14022 |
356-361 |
DT |
denotes |
these |
T14023 |
362-369 |
NNS |
denotes |
defects |
T14024 |
377-382 |
RB |
denotes |
quite |
T14025 |
383-392 |
JJ |
denotes |
different |
T14026 |
393-397 |
CC |
denotes |
both |
T14027 |
398-400 |
IN |
denotes |
in |
T14028 |
401-404 |
DT |
denotes |
the |
T14029 |
433-440 |
NNS |
denotes |
regions |
T14030 |
405-417 |
JJ |
denotes |
craniofacial |
T14031 |
418-421 |
CC |
denotes |
and |
T14032 |
422-432 |
JJ |
denotes |
pharyngeal |
T14033 |
440-442 |
, |
denotes |
, |
T14034 |
442-451 |
VBG |
denotes |
including |
T14035 |
452-455 |
DT |
denotes |
the |
T14036 |
456-461 |
NN |
denotes |
heart |
T14037 |
461-463 |
, |
denotes |
, |
T14038 |
463-467 |
WRB |
denotes |
when |
T14039 |
468-476 |
VBN |
denotes |
compared |
T14040 |
477-479 |
IN |
denotes |
to |
T14041 |
480-483 |
DT |
denotes |
the |
T14042 |
498-505 |
NNS |
denotes |
mutants |
T14043 |
484-497 |
VBG |
denotes |
corresponding |
T14044 |
506-508 |
IN |
denotes |
of |
T14045 |
509-513 |
NN |
denotes |
Alk5 |
T14046 |
513-515 |
, |
denotes |
, |
T14047 |
515-520 |
WDT |
denotes |
which |
T14048 |
521-528 |
VBZ |
denotes |
encodes |
T14049 |
529-532 |
DT |
denotes |
the |
T14050 |
546-554 |
NN |
denotes |
receptor |
T14051 |
533-536 |
NN |
denotes |
TGF |
T14052 |
537-538 |
NN |
denotes |
β |
T14053 |
536-537 |
HYPH |
denotes |
- |
T14054 |
539-543 |
NN |
denotes |
type |
T14055 |
544-545 |
CD |
denotes |
I |
T14056 |
554-556 |
, |
denotes |
, |
T14057 |
556-557 |
DT |
denotes |
a |
T14058 |
579-586 |
NN |
denotes |
partner |
T14059 |
558-570 |
JJ |
denotes |
prototypical |
T14060 |
571-578 |
NN |
denotes |
binding |
T14061 |
587-589 |
IN |
denotes |
of |
T14062 |
590-593 |
NN |
denotes |
TGF |
T14063 |
594-598 |
NN |
denotes |
βRII |
T14064 |
593-594 |
HYPH |
denotes |
- |
T14065 |
599-600 |
-LRB- |
denotes |
[ |
T14066 |
600-602 |
CD |
denotes |
19 |
T14067 |
602-603 |
-RRB- |
denotes |
] |
T14068 |
604-607 |
CC |
denotes |
and |
T14069 |
608-611 |
DT |
denotes |
the |
T14070 |
620-625 |
NN |
denotes |
study |
T14071 |
612-619 |
JJ |
denotes |
present |
T14072 |
625-626 |
-RRB- |
denotes |
) |
T14073 |
626-627 |
. |
denotes |
. |
T14074 |
627-920 |
sentence |
denotes |
While Tgfbr2/Wnt1-Cre mutants as well as mice deficient in Tgf-β2 display the PTA type A4 (truncus arteriosus with interrupted aortic arch [30]), Alk5/Wnt1-Cre mutants reported here demonstrate earlier patterning defects of the PAAs, which is particularly obvious in the 3rd pair of the PAAs. |
T14075 |
628-633 |
IN |
denotes |
While |
T14076 |
694-701 |
VBP |
denotes |
display |
T14077 |
634-640 |
NN |
denotes |
Tgfbr2 |
T14078 |
646-649 |
NN |
denotes |
Cre |
T14079 |
640-641 |
HYPH |
denotes |
/ |
T14080 |
641-645 |
NN |
denotes |
Wnt1 |
T14081 |
645-646 |
HYPH |
denotes |
- |
T14082 |
650-657 |
NNS |
denotes |
mutants |
T14083 |
658-660 |
RB |
denotes |
as |
T14084 |
666-668 |
IN |
denotes |
as |
T14085 |
661-665 |
RB |
denotes |
well |
T14086 |
669-673 |
NNS |
denotes |
mice |
T14087 |
674-683 |
JJ |
denotes |
deficient |
T14088 |
684-686 |
IN |
denotes |
in |
T14089 |
687-690 |
NN |
denotes |
Tgf |
T14090 |
691-693 |
NN |
denotes |
β2 |
T14091 |
690-691 |
HYPH |
denotes |
- |
T14092 |
810-821 |
VBP |
denotes |
demonstrate |
T14093 |
702-705 |
DT |
denotes |
the |
T14094 |
715-717 |
NN |
denotes |
A4 |
T14095 |
706-709 |
NN |
denotes |
PTA |
T14096 |
710-714 |
NN |
denotes |
type |
T14097 |
718-719 |
-LRB- |
denotes |
( |
T14098 |
719-726 |
NN |
denotes |
truncus |
T14099 |
727-737 |
NN |
denotes |
arteriosus |
T14100 |
738-742 |
IN |
denotes |
with |
T14101 |
743-754 |
VBN |
denotes |
interrupted |
T14102 |
762-766 |
NN |
denotes |
arch |
T14103 |
755-761 |
JJ |
denotes |
aortic |
T14104 |
767-768 |
-LRB- |
denotes |
[ |
T14105 |
768-770 |
CD |
denotes |
30 |
T14106 |
770-771 |
-RRB- |
denotes |
] |
T14107 |
771-772 |
-RRB- |
denotes |
) |
T14108 |
772-774 |
, |
denotes |
, |
T14109 |
774-778 |
NN |
denotes |
Alk5 |
T14110 |
784-787 |
NN |
denotes |
Cre |
T14111 |
778-779 |
HYPH |
denotes |
/ |
T14112 |
779-783 |
NN |
denotes |
Wnt1 |
T14113 |
783-784 |
HYPH |
denotes |
- |
T14114 |
788-795 |
NNS |
denotes |
mutants |
T14115 |
796-804 |
VBN |
denotes |
reported |
T14116 |
805-809 |
RB |
denotes |
here |
T14117 |
822-829 |
JJR |
denotes |
earlier |
T14118 |
841-848 |
NNS |
denotes |
defects |
T14119 |
830-840 |
NN |
denotes |
patterning |
T14120 |
849-851 |
IN |
denotes |
of |
T14121 |
852-855 |
DT |
denotes |
the |
T14122 |
856-860 |
NNS |
denotes |
PAAs |
T14123 |
860-862 |
, |
denotes |
, |
T14124 |
862-867 |
WDT |
denotes |
which |
T14125 |
868-870 |
VBZ |
denotes |
is |
T14126 |
871-883 |
RB |
denotes |
particularly |
T14127 |
884-891 |
JJ |
denotes |
obvious |
T14128 |
892-894 |
IN |
denotes |
in |
T14129 |
895-898 |
DT |
denotes |
the |
T14130 |
903-907 |
NN |
denotes |
pair |
T14131 |
899-902 |
JJ |
denotes |
3rd |
T14132 |
908-910 |
IN |
denotes |
of |
T14133 |
911-914 |
DT |
denotes |
the |
T14134 |
915-919 |
NNS |
denotes |
PAAs |
T14135 |
919-920 |
. |
denotes |
. |
T14136 |
920-1145 |
sentence |
denotes |
Moreover, the Alk5/Wnt1-Cre mutants display an abnormal patterning of the aortic sac and defective AP septation leading to PTA, reminiscent of type A2 (= truncus artriosus with no main pulmonary artery segment present [30]). |
T14137 |
921-929 |
RB |
denotes |
Moreover |
T14138 |
957-964 |
VBP |
denotes |
display |
T14139 |
929-931 |
, |
denotes |
, |
T14140 |
931-934 |
DT |
denotes |
the |
T14141 |
949-956 |
NNS |
denotes |
mutants |
T14142 |
935-939 |
NN |
denotes |
Alk5 |
T14143 |
945-948 |
NN |
denotes |
Cre |
T14144 |
939-940 |
HYPH |
denotes |
/ |
T14145 |
940-944 |
NN |
denotes |
Wnt1 |
T14146 |
944-945 |
HYPH |
denotes |
- |
T14147 |
965-967 |
DT |
denotes |
an |
T14148 |
977-987 |
NN |
denotes |
patterning |
T14149 |
968-976 |
JJ |
denotes |
abnormal |
T14150 |
988-990 |
IN |
denotes |
of |
T14151 |
991-994 |
DT |
denotes |
the |
T14152 |
1002-1005 |
NN |
denotes |
sac |
T14153 |
995-1001 |
JJ |
denotes |
aortic |
T14154 |
1006-1009 |
CC |
denotes |
and |
T14155 |
1010-1019 |
JJ |
denotes |
defective |
T14156 |
1023-1032 |
NN |
denotes |
septation |
T14157 |
1020-1022 |
NN |
denotes |
AP |
T14158 |
1033-1040 |
VBG |
denotes |
leading |
T14159 |
1041-1043 |
IN |
denotes |
to |
T14160 |
1044-1047 |
NN |
denotes |
PTA |
T14161 |
1047-1049 |
, |
denotes |
, |
T14162 |
1049-1060 |
JJ |
denotes |
reminiscent |
T14163 |
1061-1063 |
IN |
denotes |
of |
T14164 |
1064-1068 |
NN |
denotes |
type |
T14165 |
1069-1071 |
NN |
denotes |
A2 |
T14166 |
1072-1073 |
-LRB- |
denotes |
( |
T14167 |
1073-1074 |
SYM |
denotes |
= |
T14168 |
1083-1092 |
NN |
denotes |
artriosus |
T14169 |
1075-1082 |
NN |
denotes |
truncus |
T14170 |
1093-1097 |
IN |
denotes |
with |
T14171 |
1098-1100 |
DT |
denotes |
no |
T14172 |
1123-1130 |
NN |
denotes |
segment |
T14173 |
1101-1105 |
JJ |
denotes |
main |
T14174 |
1106-1115 |
JJ |
denotes |
pulmonary |
T14175 |
1116-1122 |
NN |
denotes |
artery |
T14176 |
1131-1138 |
JJ |
denotes |
present |
T14177 |
1139-1140 |
-LRB- |
denotes |
[ |
T14178 |
1140-1142 |
CD |
denotes |
30 |
T14179 |
1142-1143 |
-RRB- |
denotes |
] |
T14180 |
1143-1144 |
-RRB- |
denotes |
) |
T14181 |
1144-1145 |
. |
denotes |
. |
T14182 |
1145-1389 |
sentence |
denotes |
However, our results also demonstrate that significant hypoplasia of the aortic sac leads to a severe shortening of the ascending truncal arch, which masks possible defects in derivatives of the 4th PAAs, i.e., interruption of the aortic arch. |
T14183 |
1146-1153 |
RB |
denotes |
However |
T14184 |
1172-1183 |
VBP |
denotes |
demonstrate |
T14185 |
1153-1155 |
, |
denotes |
, |
T14186 |
1155-1158 |
PRP$ |
denotes |
our |
T14187 |
1159-1166 |
NNS |
denotes |
results |
T14188 |
1167-1171 |
RB |
denotes |
also |
T14189 |
1184-1188 |
IN |
denotes |
that |
T14190 |
1230-1235 |
VBZ |
denotes |
leads |
T14191 |
1189-1200 |
JJ |
denotes |
significant |
T14192 |
1201-1211 |
NN |
denotes |
hypoplasia |
T14193 |
1212-1214 |
IN |
denotes |
of |
T14194 |
1215-1218 |
DT |
denotes |
the |
T14195 |
1226-1229 |
NN |
denotes |
sac |
T14196 |
1219-1225 |
JJ |
denotes |
aortic |
T14197 |
1236-1238 |
IN |
denotes |
to |
T14198 |
1239-1240 |
DT |
denotes |
a |
T14199 |
1248-1258 |
NN |
denotes |
shortening |
T14200 |
1241-1247 |
JJ |
denotes |
severe |
T14201 |
1259-1261 |
IN |
denotes |
of |
T14202 |
1262-1265 |
DT |
denotes |
the |
T14203 |
1284-1288 |
NN |
denotes |
arch |
T14204 |
1266-1275 |
VBG |
denotes |
ascending |
T14205 |
1276-1283 |
JJ |
denotes |
truncal |
T14206 |
1288-1290 |
, |
denotes |
, |
T14207 |
1290-1295 |
WDT |
denotes |
which |
T14208 |
1296-1301 |
VBZ |
denotes |
masks |
T14209 |
1302-1310 |
JJ |
denotes |
possible |
T14210 |
1311-1318 |
NNS |
denotes |
defects |
T14211 |
1319-1321 |
IN |
denotes |
in |
T14212 |
1322-1333 |
NNS |
denotes |
derivatives |
T14213 |
1334-1336 |
IN |
denotes |
of |
T14214 |
1337-1340 |
DT |
denotes |
the |
T14215 |
1345-1349 |
NNS |
denotes |
PAAs |
T14216 |
1341-1344 |
JJ |
denotes |
4th |
T14217 |
1349-1351 |
, |
denotes |
, |
T14218 |
1351-1355 |
FW |
denotes |
i.e. |
T14219 |
1357-1369 |
NN |
denotes |
interruption |
T14220 |
1355-1357 |
, |
denotes |
, |
T14221 |
1370-1372 |
IN |
denotes |
of |
T14222 |
1373-1376 |
DT |
denotes |
the |
T14223 |
1384-1388 |
NN |
denotes |
arch |
T14224 |
1377-1383 |
JJ |
denotes |
aortic |
T14225 |
1388-1389 |
. |
denotes |
. |
T14226 |
1389-1635 |
sentence |
denotes |
These observed differences are likely due to substantial apoptosis of Alk5-deficient post-migratory neural crest cells, which is clearly detectable at E10.5, whereas similar intense cell death has not been reported in Tgfbr2/Wnt1-Cre mutants[9]. |
T14227 |
1390-1395 |
DT |
denotes |
These |
T14228 |
1405-1416 |
NNS |
denotes |
differences |
T14229 |
1396-1404 |
VBN |
denotes |
observed |
T14230 |
1417-1420 |
VBP |
denotes |
are |
T14231 |
1421-1427 |
RB |
denotes |
likely |
T14232 |
1428-1431 |
IN |
denotes |
due |
T14233 |
1432-1434 |
IN |
denotes |
to |
T14234 |
1435-1446 |
JJ |
denotes |
substantial |
T14235 |
1447-1456 |
NN |
denotes |
apoptosis |
T14236 |
1457-1459 |
IN |
denotes |
of |
T14237 |
1460-1464 |
NN |
denotes |
Alk5 |
T14238 |
1465-1474 |
JJ |
denotes |
deficient |
T14239 |
1464-1465 |
HYPH |
denotes |
- |
T14240 |
1503-1508 |
NNS |
denotes |
cells |
T14241 |
1475-1489 |
JJ |
denotes |
post-migratory |
T14242 |
1490-1496 |
JJ |
denotes |
neural |
T14243 |
1497-1502 |
NN |
denotes |
crest |
T14244 |
1508-1510 |
, |
denotes |
, |
T14245 |
1510-1515 |
WDT |
denotes |
which |
T14246 |
1516-1518 |
VBZ |
denotes |
is |
T14247 |
1519-1526 |
RB |
denotes |
clearly |
T14248 |
1527-1537 |
JJ |
denotes |
detectable |
T14249 |
1538-1540 |
IN |
denotes |
at |
T14250 |
1541-1546 |
NN |
denotes |
E10.5 |
T14251 |
1546-1548 |
, |
denotes |
, |
T14252 |
1548-1555 |
IN |
denotes |
whereas |
T14253 |
1596-1604 |
VBN |
denotes |
reported |
T14254 |
1556-1563 |
JJ |
denotes |
similar |
T14256 |
1564-1571 |
JJ |
denotes |
intense |
T14257 |
1572-1576 |
NN |
denotes |
cell |
T14258 |
1583-1586 |
VBZ |
denotes |
has |
T14259 |
1587-1590 |
RB |
denotes |
not |
T14260 |
1591-1595 |
VBN |
denotes |
been |
T14261 |
1605-1607 |
IN |
denotes |
in |
T14262 |
1608-1614 |
NN |
denotes |
Tgfbr2 |
T14263 |
1620-1623 |
NN |
denotes |
Cre |
T14264 |
1614-1615 |
HYPH |
denotes |
/ |
T14265 |
1615-1619 |
NN |
denotes |
Wnt1 |
T14266 |
1619-1620 |
HYPH |
denotes |
- |
T14267 |
1624-1631 |
NNS |
denotes |
mutants |
T14268 |
1631-1632 |
-LRB- |
denotes |
[ |
T14269 |
1632-1633 |
CD |
denotes |
9 |
T14270 |
1633-1634 |
-RRB- |
denotes |
] |
T14271 |
1634-1635 |
. |
denotes |
. |
T14255 |
1577-1582 |
NN |
denotes |
death |
R3452 |
T13939 |
T13940 |
prep |
During,proven |
R3453 |
T13941 |
T13942 |
det |
the,years |
R3454 |
T13942 |
T13939 |
pobj |
years,During |
R3455 |
T13943 |
T13942 |
amod |
last,years |
R3456 |
T13944 |
T13942 |
amod |
few,years |
R3457 |
T13945 |
T13946 |
det |
the,line |
R3458 |
T13946 |
T13940 |
nsubj |
line,proven |
R3459 |
T13947 |
T13948 |
compound |
Wnt1,Cre |
R3460 |
T13948 |
T13950 |
npadvmod |
Cre,transgenic |
R3461 |
T13949 |
T13948 |
punct |
-,Cre |
R3462 |
T13950 |
T13946 |
amod |
transgenic,line |
R3463 |
T13951 |
T13946 |
compound |
driver,line |
R3464 |
T13952 |
T13940 |
aux |
has,proven |
R3465 |
T13953 |
T13954 |
aux |
to,be |
R3466 |
T13954 |
T13940 |
xcomp |
be,proven |
R3467 |
T13955 |
T13956 |
det |
a,tool |
R3468 |
T13956 |
T13954 |
attr |
tool,be |
R3469 |
T13957 |
T13956 |
amod |
powerful,tool |
R3470 |
T13958 |
T13956 |
prep |
for,tool |
R3471 |
T13959 |
T13960 |
npadvmod |
tissue,specific |
R3472 |
T13960 |
T13962 |
amod |
specific,deletion |
R3473 |
T13961 |
T13960 |
punct |
-,specific |
R3474 |
T13962 |
T13958 |
pobj |
deletion,for |
R3475 |
T13963 |
T13962 |
compound |
gene,deletion |
R3476 |
T13964 |
T13962 |
prep |
in,deletion |
R3477 |
T13965 |
T13964 |
pobj |
NCCs,in |
R3478 |
T13966 |
T13967 |
punct |
[,28 |
R3479 |
T13967 |
T13954 |
parataxis |
28,be |
R3480 |
T13968 |
T13967 |
nummod |
12,28 |
R3481 |
T13969 |
T13967 |
punct |
",",28 |
R3482 |
T13970 |
T13967 |
nummod |
13,28 |
R3483 |
T13971 |
T13967 |
punct |
",",28 |
R3484 |
T13972 |
T13967 |
nummod |
27,28 |
R3485 |
T13973 |
T13967 |
punct |
",",28 |
R3486 |
T13974 |
T13967 |
punct |
],28 |
R3487 |
T13975 |
T13940 |
punct |
.,proven |
R3488 |
T13977 |
T13978 |
advcl |
Using,shown |
R3489 |
T13979 |
T13980 |
det |
this,approach |
R3490 |
T13980 |
T13977 |
dobj |
approach,Using |
R3491 |
T13981 |
T13978 |
punct |
", ",shown |
R3492 |
T13982 |
T13983 |
amod |
several,studies |
R3493 |
T13983 |
T13978 |
nsubj |
studies,shown |
R3494 |
T13984 |
T13978 |
aux |
have,shown |
R3495 |
T13985 |
T13978 |
advmod |
independently,shown |
R3496 |
T13986 |
T13987 |
mark |
that,leads |
R3497 |
T13987 |
T13978 |
ccomp |
leads,shown |
R3498 |
T13988 |
T13989 |
det |
the,deletion |
R3499 |
T13989 |
T13987 |
nsubj |
deletion,leads |
R3500 |
T13990 |
T13991 |
npadvmod |
NC,specific |
R3501 |
T13991 |
T13989 |
amod |
specific,deletion |
R3502 |
T13992 |
T13991 |
punct |
-,specific |
R3503 |
T13993 |
T13989 |
prep |
of,deletion |
R3504 |
T13994 |
T13995 |
det |
the,gene |
R3505 |
T13995 |
T13993 |
pobj |
gene,of |
R3506 |
T13996 |
T13995 |
compound |
Tgfbr2,gene |
R3507 |
T13997 |
T13987 |
prep |
to,leads |
R3508 |
T13998 |
T13999 |
det |
a,set |
R3509 |
T13999 |
T13997 |
pobj |
set,to |
R3510 |
T14000 |
T13999 |
amod |
distinct,set |
R3511 |
T14001 |
T13999 |
prep |
of,set |
R3512 |
T14002 |
T14003 |
amod |
calvarial,defects |
R3513 |
T14003 |
T14001 |
pobj |
defects,of |
R3514 |
T14004 |
T14002 |
punct |
", ",calvarial |
R3515 |
T14005 |
T14002 |
conj |
facial,calvarial |
R3516 |
T14006 |
T14005 |
cc |
and,facial |
R3517 |
T14007 |
T14005 |
conj |
cardiac,facial |
R3518 |
T14008 |
T14009 |
punct |
[,29 |
R3519 |
T14009 |
T13978 |
parataxis |
29,shown |
R3520 |
T14010 |
T14009 |
nummod |
8,29 |
R3521 |
T14011 |
T14009 |
punct |
",",29 |
R3522 |
T14012 |
T14009 |
nummod |
9,29 |
R3523 |
T14013 |
T14009 |
punct |
",",29 |
R3524 |
T14014 |
T14009 |
nummod |
20,29 |
R3525 |
T14015 |
T14009 |
punct |
",",29 |
R3526 |
T14016 |
T14009 |
punct |
],29 |
R3527 |
T14017 |
T13978 |
punct |
.,shown |
R3528 |
T14019 |
T14020 |
advmod |
Interestingly,appear |
R3529 |
T14021 |
T14020 |
punct |
", ",appear |
R3530 |
T14022 |
T14023 |
det |
these,defects |
R3531 |
T14023 |
T14020 |
nsubj |
defects,appear |
R3532 |
T14024 |
T14025 |
advmod |
quite,different |
R3533 |
T14025 |
T14020 |
oprd |
different,appear |
R3534 |
T14026 |
T14027 |
preconj |
both,in |
R3535 |
T14027 |
T14020 |
prep |
in,appear |
R3536 |
T14028 |
T14029 |
det |
the,regions |
R3537 |
T14029 |
T14027 |
pobj |
regions,in |
R3538 |
T14030 |
T14029 |
amod |
craniofacial,regions |
R3539 |
T14031 |
T14030 |
cc |
and,craniofacial |
R3540 |
T14032 |
T14030 |
conj |
pharyngeal,craniofacial |
R3541 |
T14033 |
T14029 |
punct |
", ",regions |
R3542 |
T14034 |
T14029 |
prep |
including,regions |
R3543 |
T14035 |
T14036 |
det |
the,heart |
R3544 |
T14036 |
T14034 |
pobj |
heart,including |
R3545 |
T14037 |
T14020 |
punct |
", ",appear |
R3546 |
T14038 |
T14039 |
advmod |
when,compared |
R3547 |
T14039 |
T14020 |
advcl |
compared,appear |
R3548 |
T14040 |
T14039 |
prep |
to,compared |
R3549 |
T14041 |
T14042 |
det |
the,mutants |
R3550 |
T14042 |
T14040 |
pobj |
mutants,to |
R3551 |
T14043 |
T14042 |
amod |
corresponding,mutants |
R3552 |
T14044 |
T14042 |
prep |
of,mutants |
R3553 |
T14045 |
T14044 |
pobj |
Alk5,of |
R3554 |
T14046 |
T14042 |
punct |
", ",mutants |
R3555 |
T14047 |
T14048 |
dep |
which,encodes |
R3556 |
T14048 |
T14042 |
relcl |
encodes,mutants |
R3557 |
T14049 |
T14050 |
det |
the,receptor |
R3558 |
T14050 |
T14048 |
dobj |
receptor,encodes |
R3559 |
T14051 |
T14052 |
nmod |
TGF,β |
R3560 |
T14052 |
T14050 |
nmod |
β,receptor |
R3561 |
T14053 |
T14052 |
punct |
-,β |
R3562 |
T14054 |
T14050 |
nmod |
type,receptor |
R3563 |
T14055 |
T14054 |
nummod |
I,type |
R3564 |
T14056 |
T14050 |
punct |
", ",receptor |
R3565 |
T14057 |
T14058 |
det |
a,partner |
R3566 |
T14058 |
T14050 |
appos |
partner,receptor |
R3567 |
T14059 |
T14058 |
amod |
prototypical,partner |
R3568 |
T14060 |
T14058 |
compound |
binding,partner |
R3569 |
T14061 |
T14058 |
prep |
of,partner |
R3570 |
T14062 |
T14063 |
compound |
TGF,βRII |
R3571 |
T14063 |
T14061 |
pobj |
βRII,of |
R3572 |
T14064 |
T14063 |
punct |
-,βRII |
R3573 |
T14065 |
T14066 |
punct |
[,19 |
R3574 |
T14066 |
T14039 |
parataxis |
19,compared |
R3575 |
T14067 |
T14066 |
punct |
],19 |
R3576 |
T14068 |
T14066 |
cc |
and,19 |
R3577 |
T14069 |
T14070 |
det |
the,study |
R3578 |
T14070 |
T14066 |
conj |
study,19 |
R3579 |
T14071 |
T14070 |
amod |
present,study |
R3580 |
T14072 |
T14066 |
punct |
),19 |
R3581 |
T14073 |
T14020 |
punct |
.,appear |
R3582 |
T14075 |
T14076 |
mark |
While,display |
R3583 |
T14076 |
T14092 |
advcl |
display,demonstrate |
R3584 |
T14077 |
T14078 |
compound |
Tgfbr2,Cre |
R3585 |
T14078 |
T14082 |
compound |
Cre,mutants |
R3586 |
T14079 |
T14078 |
punct |
/,Cre |
R3587 |
T14080 |
T14078 |
compound |
Wnt1,Cre |
R3588 |
T14081 |
T14078 |
punct |
-,Cre |
R3589 |
T14082 |
T14076 |
nsubj |
mutants,display |
R3590 |
T14083 |
T14084 |
advmod |
as,as |
R3591 |
T14084 |
T14082 |
cc |
as,mutants |
R3592 |
T14085 |
T14084 |
advmod |
well,as |
R3593 |
T14086 |
T14082 |
conj |
mice,mutants |
R3594 |
T14087 |
T14086 |
amod |
deficient,mice |
R3595 |
T14088 |
T14087 |
prep |
in,deficient |
R3596 |
T14089 |
T14090 |
compound |
Tgf,β2 |
R3597 |
T14090 |
T14088 |
pobj |
β2,in |
R3598 |
T14091 |
T14090 |
punct |
-,β2 |
R3599 |
T14093 |
T14094 |
det |
the,A4 |
R3600 |
T14094 |
T14076 |
dobj |
A4,display |
R3601 |
T14095 |
T14094 |
compound |
PTA,A4 |
R3602 |
T14096 |
T14094 |
compound |
type,A4 |
R3603 |
T14097 |
T14094 |
punct |
(,A4 |
R3604 |
T14098 |
T14099 |
compound |
truncus,arteriosus |
R3605 |
T14099 |
T14094 |
appos |
arteriosus,A4 |
R3606 |
T14100 |
T14099 |
prep |
with,arteriosus |
R3607 |
T14101 |
T14102 |
amod |
interrupted,arch |
R3608 |
T14102 |
T14100 |
pobj |
arch,with |
R3609 |
T14103 |
T14102 |
amod |
aortic,arch |
R3610 |
T14104 |
T14105 |
punct |
[,30 |
R3611 |
T14105 |
T14076 |
parataxis |
30,display |
R3612 |
T14106 |
T14105 |
punct |
],30 |
R3613 |
T14107 |
T14092 |
punct |
),demonstrate |
R3614 |
T14108 |
T14092 |
punct |
", ",demonstrate |
R3615 |
T14109 |
T14110 |
compound |
Alk5,Cre |
R3616 |
T14110 |
T14114 |
compound |
Cre,mutants |
R3617 |
T14111 |
T14110 |
punct |
/,Cre |
R3618 |
T14112 |
T14110 |
compound |
Wnt1,Cre |
R3619 |
T14113 |
T14110 |
punct |
-,Cre |
R3620 |
T14114 |
T14092 |
nsubj |
mutants,demonstrate |
R3621 |
T14115 |
T14114 |
acl |
reported,mutants |
R3622 |
T14116 |
T14115 |
advmod |
here,reported |
R3623 |
T14117 |
T14118 |
amod |
earlier,defects |
R3624 |
T14118 |
T14092 |
dobj |
defects,demonstrate |
R3625 |
T14119 |
T14118 |
compound |
patterning,defects |
R3626 |
T14120 |
T14118 |
prep |
of,defects |
R3627 |
T14121 |
T14122 |
det |
the,PAAs |
R3628 |
T14122 |
T14120 |
pobj |
PAAs,of |
R3629 |
T14123 |
T14118 |
punct |
", ",defects |
R3630 |
T14124 |
T14125 |
dep |
which,is |
R3631 |
T14125 |
T14118 |
relcl |
is,defects |
R3632 |
T14126 |
T14127 |
advmod |
particularly,obvious |
R3633 |
T14127 |
T14125 |
acomp |
obvious,is |
R3634 |
T14128 |
T14125 |
prep |
in,is |
R3635 |
T14129 |
T14130 |
det |
the,pair |
R3636 |
T14130 |
T14128 |
pobj |
pair,in |
R3637 |
T14131 |
T14130 |
amod |
3rd,pair |
R3638 |
T14132 |
T14130 |
prep |
of,pair |
R3639 |
T14133 |
T14134 |
det |
the,PAAs |
R3640 |
T14134 |
T14132 |
pobj |
PAAs,of |
R3641 |
T14135 |
T14092 |
punct |
.,demonstrate |
R3642 |
T14137 |
T14138 |
advmod |
Moreover,display |
R3643 |
T14139 |
T14138 |
punct |
", ",display |
R3644 |
T14140 |
T14141 |
det |
the,mutants |
R3645 |
T14141 |
T14138 |
nsubj |
mutants,display |
R3646 |
T14142 |
T14143 |
compound |
Alk5,Cre |
R3647 |
T14143 |
T14141 |
compound |
Cre,mutants |
R3648 |
T14144 |
T14143 |
punct |
/,Cre |
R3649 |
T14145 |
T14143 |
compound |
Wnt1,Cre |
R3650 |
T14146 |
T14143 |
punct |
-,Cre |
R3651 |
T14147 |
T14148 |
det |
an,patterning |
R3652 |
T14148 |
T14138 |
dobj |
patterning,display |
R3653 |
T14149 |
T14148 |
amod |
abnormal,patterning |
R3654 |
T14150 |
T14148 |
prep |
of,patterning |
R3655 |
T14151 |
T14152 |
det |
the,sac |
R3656 |
T14152 |
T14150 |
pobj |
sac,of |
R3657 |
T14153 |
T14152 |
amod |
aortic,sac |
R3658 |
T14154 |
T14148 |
cc |
and,patterning |
R3659 |
T14155 |
T14156 |
amod |
defective,septation |
R3660 |
T14156 |
T14148 |
conj |
septation,patterning |
R3661 |
T14157 |
T14156 |
compound |
AP,septation |
R3662 |
T14158 |
T14156 |
acl |
leading,septation |
R3663 |
T14159 |
T14158 |
prep |
to,leading |
R3664 |
T14160 |
T14159 |
pobj |
PTA,to |
R3665 |
T14161 |
T14148 |
punct |
", ",patterning |
R3666 |
T14162 |
T14148 |
amod |
reminiscent,patterning |
R3667 |
T14163 |
T14162 |
prep |
of,reminiscent |
R3668 |
T14164 |
T14165 |
compound |
type,A2 |
R3669 |
T14165 |
T14163 |
pobj |
A2,of |
R3670 |
T14166 |
T14165 |
punct |
(,A2 |
R3671 |
T14167 |
T14168 |
punct |
=,artriosus |
R3672 |
T14168 |
T14165 |
acl |
artriosus,A2 |
R3673 |
T14169 |
T14168 |
compound |
truncus,artriosus |
R3674 |
T14170 |
T14168 |
prep |
with,artriosus |
R3675 |
T14171 |
T14172 |
det |
no,segment |
R3676 |
T14172 |
T14170 |
pobj |
segment,with |
R3677 |
T14173 |
T14172 |
amod |
main,segment |
R3678 |
T14174 |
T14172 |
amod |
pulmonary,segment |
R3679 |
T14175 |
T14172 |
compound |
artery,segment |
R3680 |
T14176 |
T14172 |
amod |
present,segment |
R3681 |
T14177 |
T14178 |
punct |
[,30 |
R3682 |
T14178 |
T14148 |
parataxis |
30,patterning |
R3683 |
T14179 |
T14178 |
punct |
],30 |
R3684 |
T14180 |
T14138 |
punct |
),display |
R3685 |
T14181 |
T14138 |
punct |
.,display |
R3686 |
T14183 |
T14184 |
advmod |
However,demonstrate |
R3687 |
T14185 |
T14184 |
punct |
", ",demonstrate |
R3688 |
T14186 |
T14187 |
poss |
our,results |
R3689 |
T14187 |
T14184 |
nsubj |
results,demonstrate |
R3690 |
T14188 |
T14184 |
advmod |
also,demonstrate |
R3691 |
T14189 |
T14190 |
mark |
that,leads |
R3692 |
T14190 |
T14184 |
ccomp |
leads,demonstrate |
R3693 |
T14191 |
T14192 |
amod |
significant,hypoplasia |
R3694 |
T14192 |
T14190 |
nsubj |
hypoplasia,leads |
R3695 |
T14193 |
T14192 |
prep |
of,hypoplasia |
R3696 |
T14194 |
T14195 |
det |
the,sac |
R3697 |
T14195 |
T14193 |
pobj |
sac,of |
R3698 |
T14196 |
T14195 |
amod |
aortic,sac |
R3699 |
T14197 |
T14190 |
prep |
to,leads |
R3700 |
T14198 |
T14199 |
det |
a,shortening |
R3701 |
T14199 |
T14197 |
pobj |
shortening,to |
R3702 |
T14200 |
T14199 |
amod |
severe,shortening |
R3703 |
T14201 |
T14199 |
prep |
of,shortening |
R3704 |
T14202 |
T14203 |
det |
the,arch |
R3705 |
T14203 |
T14201 |
pobj |
arch,of |
R3706 |
T14204 |
T14203 |
amod |
ascending,arch |
R3707 |
T14205 |
T14203 |
amod |
truncal,arch |
R3708 |
T14206 |
T14199 |
punct |
", ",shortening |
R3709 |
T14207 |
T14208 |
dep |
which,masks |
R3710 |
T14208 |
T14199 |
relcl |
masks,shortening |
R3711 |
T14209 |
T14210 |
amod |
possible,defects |
R3712 |
T14210 |
T14208 |
dobj |
defects,masks |
R3713 |
T14211 |
T14210 |
prep |
in,defects |
R3714 |
T14212 |
T14211 |
pobj |
derivatives,in |
R3715 |
T14213 |
T14212 |
prep |
of,derivatives |
R3716 |
T14214 |
T14215 |
det |
the,PAAs |
R3717 |
T14215 |
T14213 |
pobj |
PAAs,of |
R3718 |
T14216 |
T14215 |
amod |
4th,PAAs |
R3719 |
T14217 |
T14210 |
punct |
", ",defects |
R3720 |
T14218 |
T14219 |
advmod |
i.e.,interruption |
R3721 |
T14219 |
T14210 |
appos |
interruption,defects |
R3722 |
T14220 |
T14219 |
punct |
", ",interruption |
R3723 |
T14221 |
T14219 |
prep |
of,interruption |
R3724 |
T14222 |
T14223 |
det |
the,arch |
R3725 |
T14223 |
T14221 |
pobj |
arch,of |
R3726 |
T14224 |
T14223 |
amod |
aortic,arch |
R3727 |
T14225 |
T14184 |
punct |
.,demonstrate |
R3728 |
T14227 |
T14228 |
det |
These,differences |
R3729 |
T14228 |
T14230 |
nsubj |
differences,are |
R3730 |
T14229 |
T14228 |
amod |
observed,differences |
R3731 |
T14231 |
T14232 |
advmod |
likely,due |
R3732 |
T14232 |
T14230 |
prep |
due,are |
R3733 |
T14233 |
T14232 |
pcomp |
to,due |
R3734 |
T14234 |
T14235 |
amod |
substantial,apoptosis |
R3735 |
T14235 |
T14232 |
pobj |
apoptosis,due |
R3736 |
T14236 |
T14235 |
prep |
of,apoptosis |
R3737 |
T14237 |
T14238 |
npadvmod |
Alk5,deficient |
R3738 |
T14238 |
T14240 |
amod |
deficient,cells |
R3739 |
T14239 |
T14238 |
punct |
-,deficient |
R3740 |
T14240 |
T14236 |
pobj |
cells,of |
R3741 |
T14241 |
T14240 |
amod |
post-migratory,cells |
R3742 |
T14242 |
T14243 |
amod |
neural,crest |
R3743 |
T14243 |
T14240 |
compound |
crest,cells |
R3744 |
T14244 |
T14235 |
punct |
", ",apoptosis |
R3745 |
T14245 |
T14246 |
dep |
which,is |
R3746 |
T14246 |
T14235 |
relcl |
is,apoptosis |
R3747 |
T14247 |
T14248 |
advmod |
clearly,detectable |
R3748 |
T14248 |
T14246 |
acomp |
detectable,is |
R3749 |
T14249 |
T14246 |
prep |
at,is |
R3750 |
T14250 |
T14249 |
pobj |
E10.5,at |
R3751 |
T14251 |
T14246 |
punct |
", ",is |
R3752 |
T14252 |
T14253 |
mark |
whereas,reported |
R3753 |
T14253 |
T14246 |
advcl |
reported,is |
R3754 |
T14254 |
T14255 |
amod |
similar,death |
R3755 |
T14255 |
T14253 |
nsubjpass |
death,reported |
R3756 |
T14256 |
T14255 |
amod |
intense,death |
R3757 |
T14257 |
T14255 |
compound |
cell,death |
R3758 |
T14258 |
T14253 |
aux |
has,reported |
R3759 |
T14259 |
T14253 |
neg |
not,reported |
R3760 |
T14260 |
T14253 |
auxpass |
been,reported |
R3761 |
T14261 |
T14253 |
prep |
in,reported |
R3762 |
T14262 |
T14263 |
compound |
Tgfbr2,Cre |
R3763 |
T14263 |
T14267 |
compound |
Cre,mutants |
R3764 |
T14264 |
T14263 |
punct |
/,Cre |
R3765 |
T14265 |
T14263 |
compound |
Wnt1,Cre |
R3766 |
T14266 |
T14263 |
punct |
-,Cre |
R3767 |
T14267 |
T14261 |
pobj |
mutants,in |
R3768 |
T14268 |
T14269 |
punct |
[,9 |
R3769 |
T14269 |
T14230 |
parataxis |
9,are |
R3770 |
T14270 |
T14269 |
punct |
],9 |
R3771 |
T14271 |
T14230 |
punct |
.,are |