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Id Subject Object Predicate Lexical cue
T13939 11-17 IN denotes During
T13940 77-83 VBN denotes proven
T13941 18-21 DT denotes the
T13942 31-36 NNS denotes years
T13943 22-26 JJ denotes last
T13944 27-30 JJ denotes few
T13945 37-40 DT denotes the
T13946 68-72 NN denotes line
T13947 41-45 NN denotes Wnt1
T13948 46-49 NN denotes Cre
T13949 45-46 HYPH denotes -
T13950 50-60 JJ denotes transgenic
T13951 61-67 NN denotes driver
T13952 73-76 VBZ denotes has
T13953 84-86 TO denotes to
T13954 87-89 VB denotes be
T13955 90-91 DT denotes a
T13956 101-105 NN denotes tool
T13957 92-100 JJ denotes powerful
T13958 106-109 IN denotes for
T13959 110-116 NN denotes tissue
T13960 117-125 JJ denotes specific
T13961 116-117 HYPH denotes -
T13962 131-139 NN denotes deletion
T13963 126-130 NN denotes gene
T13964 140-142 IN denotes in
T13965 143-147 NNS denotes NCCs
T13966 148-149 -LRB- denotes [
T13967 158-160 CD denotes 28
T13968 149-151 CD denotes 12
T13969 151-152 , denotes ,
T13970 152-154 CD denotes 13
T13971 154-155 , denotes ,
T13972 155-157 CD denotes 27
T13973 157-158 , denotes ,
T13974 160-161 -RRB- denotes ]
T13975 161-162 . denotes .
T13976 162-351 sentence denotes Using this approach, several studies have independently shown that the NC-specific deletion of the Tgfbr2 gene leads to a distinct set of calvarial, facial and cardiac defects [8,9,20,29].
T13977 163-168 VBG denotes Using
T13978 219-224 VBN denotes shown
T13979 169-173 DT denotes this
T13980 174-182 NN denotes approach
T13981 182-184 , denotes ,
T13982 184-191 JJ denotes several
T13983 192-199 NNS denotes studies
T13984 200-204 VBP denotes have
T13985 205-218 RB denotes independently
T13986 225-229 IN denotes that
T13987 274-279 VBZ denotes leads
T13988 230-233 DT denotes the
T13989 246-254 NN denotes deletion
T13990 234-236 NN denotes NC
T13991 237-245 JJ denotes specific
T13992 236-237 HYPH denotes -
T13993 255-257 IN denotes of
T13994 258-261 DT denotes the
T13995 269-273 NN denotes gene
T13996 262-268 NN denotes Tgfbr2
T13997 280-282 IN denotes to
T13998 283-284 DT denotes a
T13999 294-297 NN denotes set
T14000 285-293 JJ denotes distinct
T14001 298-300 IN denotes of
T14002 301-310 JJ denotes calvarial
T14003 331-338 NNS denotes defects
T14004 310-312 , denotes ,
T14005 312-318 JJ denotes facial
T14006 319-322 CC denotes and
T14007 323-330 JJ denotes cardiac
T14008 339-340 -LRB- denotes [
T14009 347-349 CD denotes 29
T14010 340-341 CD denotes 8
T14011 341-342 , denotes ,
T14012 342-343 CD denotes 9
T14013 343-344 , denotes ,
T14014 344-346 CD denotes 20
T14015 346-347 , denotes ,
T14016 349-350 -RRB- denotes ]
T14017 350-351 . denotes .
T14018 351-638 sentence denotes Interestingly, these defects appear quite different both in the craniofacial and pharyngeal regions, including the heart, when compared to the corresponding mutants of Alk5, which encodes the TGF-β type I receptor, a prototypical binding partner of TGF-βRII [19] and the present study).
T14019 352-365 RB denotes Interestingly
T14020 381-387 VBP denotes appear
T14021 365-367 , denotes ,
T14022 367-372 DT denotes these
T14023 373-380 NNS denotes defects
T14024 388-393 RB denotes quite
T14025 394-403 JJ denotes different
T14026 404-408 CC denotes both
T14027 409-411 IN denotes in
T14028 412-415 DT denotes the
T14029 444-451 NNS denotes regions
T14030 416-428 JJ denotes craniofacial
T14031 429-432 CC denotes and
T14032 433-443 JJ denotes pharyngeal
T14033 451-453 , denotes ,
T14034 453-462 VBG denotes including
T14035 463-466 DT denotes the
T14036 467-472 NN denotes heart
T14037 472-474 , denotes ,
T14038 474-478 WRB denotes when
T14039 479-487 VBN denotes compared
T14040 488-490 IN denotes to
T14041 491-494 DT denotes the
T14042 509-516 NNS denotes mutants
T14043 495-508 VBG denotes corresponding
T14044 517-519 IN denotes of
T14045 520-524 NN denotes Alk5
T14046 524-526 , denotes ,
T14047 526-531 WDT denotes which
T14048 532-539 VBZ denotes encodes
T14049 540-543 DT denotes the
T14050 557-565 NN denotes receptor
T14051 544-547 NN denotes TGF
T14052 548-549 NN denotes β
T14053 547-548 HYPH denotes -
T14054 550-554 NN denotes type
T14055 555-556 CD denotes I
T14056 565-567 , denotes ,
T14057 567-568 DT denotes a
T14058 590-597 NN denotes partner
T14059 569-581 JJ denotes prototypical
T14060 582-589 NN denotes binding
T14061 598-600 IN denotes of
T14062 601-604 NN denotes TGF
T14063 605-609 NN denotes βRII
T14064 604-605 HYPH denotes -
T14065 610-611 -LRB- denotes [
T14066 611-613 CD denotes 19
T14067 613-614 -RRB- denotes ]
T14068 615-618 CC denotes and
T14069 619-622 DT denotes the
T14070 631-636 NN denotes study
T14071 623-630 JJ denotes present
T14072 636-637 -RRB- denotes )
T14073 637-638 . denotes .
T14074 638-931 sentence denotes While Tgfbr2/Wnt1-Cre mutants as well as mice deficient in Tgf-β2 display the PTA type A4 (truncus arteriosus with interrupted aortic arch [30]), Alk5/Wnt1-Cre mutants reported here demonstrate earlier patterning defects of the PAAs, which is particularly obvious in the 3rd pair of the PAAs.
T14075 639-644 IN denotes While
T14076 705-712 VBP denotes display
T14077 645-651 NN denotes Tgfbr2
T14078 657-660 NN denotes Cre
T14079 651-652 HYPH denotes /
T14080 652-656 NN denotes Wnt1
T14081 656-657 HYPH denotes -
T14082 661-668 NNS denotes mutants
T14083 669-671 RB denotes as
T14084 677-679 IN denotes as
T14085 672-676 RB denotes well
T14086 680-684 NNS denotes mice
T14087 685-694 JJ denotes deficient
T14088 695-697 IN denotes in
T14089 698-701 NN denotes Tgf
T14090 702-704 NN denotes β2
T14091 701-702 HYPH denotes -
T14092 821-832 VBP denotes demonstrate
T14093 713-716 DT denotes the
T14094 726-728 NN denotes A4
T14095 717-720 NN denotes PTA
T14096 721-725 NN denotes type
T14097 729-730 -LRB- denotes (
T14098 730-737 NN denotes truncus
T14099 738-748 NN denotes arteriosus
T14100 749-753 IN denotes with
T14101 754-765 VBN denotes interrupted
T14102 773-777 NN denotes arch
T14103 766-772 JJ denotes aortic
T14104 778-779 -LRB- denotes [
T14105 779-781 CD denotes 30
T14106 781-782 -RRB- denotes ]
T14107 782-783 -RRB- denotes )
T14108 783-785 , denotes ,
T14109 785-789 NN denotes Alk5
T14110 795-798 NN denotes Cre
T14111 789-790 HYPH denotes /
T14112 790-794 NN denotes Wnt1
T14113 794-795 HYPH denotes -
T14114 799-806 NNS denotes mutants
T14115 807-815 VBN denotes reported
T14116 816-820 RB denotes here
T14117 833-840 JJR denotes earlier
T14118 852-859 NNS denotes defects
T14119 841-851 NN denotes patterning
T14120 860-862 IN denotes of
T14121 863-866 DT denotes the
T14122 867-871 NNS denotes PAAs
T14123 871-873 , denotes ,
T14124 873-878 WDT denotes which
T14125 879-881 VBZ denotes is
T14126 882-894 RB denotes particularly
T14127 895-902 JJ denotes obvious
T14128 903-905 IN denotes in
T14129 906-909 DT denotes the
T14130 914-918 NN denotes pair
T14131 910-913 JJ denotes 3rd
T14132 919-921 IN denotes of
T14133 922-925 DT denotes the
T14134 926-930 NNS denotes PAAs
T14135 930-931 . denotes .
T14136 931-1156 sentence denotes Moreover, the Alk5/Wnt1-Cre mutants display an abnormal patterning of the aortic sac and defective AP septation leading to PTA, reminiscent of type A2 (= truncus artriosus with no main pulmonary artery segment present [30]).
T14137 932-940 RB denotes Moreover
T14138 968-975 VBP denotes display
T14139 940-942 , denotes ,
T14140 942-945 DT denotes the
T14141 960-967 NNS denotes mutants
T14142 946-950 NN denotes Alk5
T14143 956-959 NN denotes Cre
T14144 950-951 HYPH denotes /
T14145 951-955 NN denotes Wnt1
T14146 955-956 HYPH denotes -
T14147 976-978 DT denotes an
T14148 988-998 NN denotes patterning
T14149 979-987 JJ denotes abnormal
T14150 999-1001 IN denotes of
T14151 1002-1005 DT denotes the
T14152 1013-1016 NN denotes sac
T14153 1006-1012 JJ denotes aortic
T14154 1017-1020 CC denotes and
T14155 1021-1030 JJ denotes defective
T14156 1034-1043 NN denotes septation
T14157 1031-1033 NN denotes AP
T14158 1044-1051 VBG denotes leading
T14159 1052-1054 IN denotes to
T14160 1055-1058 NN denotes PTA
T14161 1058-1060 , denotes ,
T14162 1060-1071 JJ denotes reminiscent
T14163 1072-1074 IN denotes of
T14164 1075-1079 NN denotes type
T14165 1080-1082 NN denotes A2
T14166 1083-1084 -LRB- denotes (
T14167 1084-1085 SYM denotes =
T14168 1094-1103 NN denotes artriosus
T14169 1086-1093 NN denotes truncus
T14170 1104-1108 IN denotes with
T14171 1109-1111 DT denotes no
T14172 1134-1141 NN denotes segment
T14173 1112-1116 JJ denotes main
T14174 1117-1126 JJ denotes pulmonary
T14175 1127-1133 NN denotes artery
T14176 1142-1149 JJ denotes present
T14177 1150-1151 -LRB- denotes [
T14178 1151-1153 CD denotes 30
T14179 1153-1154 -RRB- denotes ]
T14180 1154-1155 -RRB- denotes )
T14181 1155-1156 . denotes .
T14182 1156-1400 sentence denotes However, our results also demonstrate that significant hypoplasia of the aortic sac leads to a severe shortening of the ascending truncal arch, which masks possible defects in derivatives of the 4th PAAs, i.e., interruption of the aortic arch.
T14183 1157-1164 RB denotes However
T14184 1183-1194 VBP denotes demonstrate
T14185 1164-1166 , denotes ,
T14186 1166-1169 PRP$ denotes our
T14187 1170-1177 NNS denotes results
T14188 1178-1182 RB denotes also
T14189 1195-1199 IN denotes that
T14190 1241-1246 VBZ denotes leads
T14191 1200-1211 JJ denotes significant
T14192 1212-1222 NN denotes hypoplasia
T14193 1223-1225 IN denotes of
T14194 1226-1229 DT denotes the
T14195 1237-1240 NN denotes sac
T14196 1230-1236 JJ denotes aortic
T14197 1247-1249 IN denotes to
T14198 1250-1251 DT denotes a
T14199 1259-1269 NN denotes shortening
T14200 1252-1258 JJ denotes severe
T14201 1270-1272 IN denotes of
T14202 1273-1276 DT denotes the
T14203 1295-1299 NN denotes arch
T14204 1277-1286 VBG denotes ascending
T14205 1287-1294 JJ denotes truncal
T14206 1299-1301 , denotes ,
T14207 1301-1306 WDT denotes which
T14208 1307-1312 VBZ denotes masks
T14209 1313-1321 JJ denotes possible
T14210 1322-1329 NNS denotes defects
T14211 1330-1332 IN denotes in
T14212 1333-1344 NNS denotes derivatives
T14213 1345-1347 IN denotes of
T14214 1348-1351 DT denotes the
T14215 1356-1360 NNS denotes PAAs
T14216 1352-1355 JJ denotes 4th
T14217 1360-1362 , denotes ,
T14218 1362-1366 FW denotes i.e.
T14219 1368-1380 NN denotes interruption
T14220 1366-1368 , denotes ,
T14221 1381-1383 IN denotes of
T14222 1384-1387 DT denotes the
T14223 1395-1399 NN denotes arch
T14224 1388-1394 JJ denotes aortic
T14225 1399-1400 . denotes .
T14226 1400-1646 sentence denotes These observed differences are likely due to substantial apoptosis of Alk5-deficient post-migratory neural crest cells, which is clearly detectable at E10.5, whereas similar intense cell death has not been reported in Tgfbr2/Wnt1-Cre mutants[9].
T14227 1401-1406 DT denotes These
T14228 1416-1427 NNS denotes differences
T14229 1407-1415 VBN denotes observed
T14230 1428-1431 VBP denotes are
T14231 1432-1438 RB denotes likely
T14232 1439-1442 IN denotes due
T14233 1443-1445 IN denotes to
T14234 1446-1457 JJ denotes substantial
T14235 1458-1467 NN denotes apoptosis
T14236 1468-1470 IN denotes of
T14237 1471-1475 NN denotes Alk5
T14238 1476-1485 JJ denotes deficient
T14239 1475-1476 HYPH denotes -
T14240 1514-1519 NNS denotes cells
T14241 1486-1500 JJ denotes post-migratory
T14242 1501-1507 JJ denotes neural
T14243 1508-1513 NN denotes crest
T14244 1519-1521 , denotes ,
T14245 1521-1526 WDT denotes which
T14246 1527-1529 VBZ denotes is
T14247 1530-1537 RB denotes clearly
T14248 1538-1548 JJ denotes detectable
T14249 1549-1551 IN denotes at
T14250 1552-1557 NN denotes E10.5
T14251 1557-1559 , denotes ,
T14252 1559-1566 IN denotes whereas
T14253 1607-1615 VBN denotes reported
T14254 1567-1574 JJ denotes similar
T14256 1575-1582 JJ denotes intense
T14257 1583-1587 NN denotes cell
T14258 1594-1597 VBZ denotes has
T14259 1598-1601 RB denotes not
T14260 1602-1606 VBN denotes been
T14261 1616-1618 IN denotes in
T14262 1619-1625 NN denotes Tgfbr2
T14263 1631-1634 NN denotes Cre
T14264 1625-1626 HYPH denotes /
T14265 1626-1630 NN denotes Wnt1
T14266 1630-1631 HYPH denotes -
T14267 1635-1642 NNS denotes mutants
T14268 1642-1643 -LRB- denotes [
T14269 1643-1644 CD denotes 9
T14270 1644-1645 -RRB- denotes ]
T14271 1645-1646 . denotes .
T14272 1646-1917 sentence denotes Our present results suggest that while TGF-β signaling in cardiac NCCs is predominantly mediated via the ALK5/TGF-βRII receptor complex, ALK5 also mediates signaling of other related ligands, which are either directly or indirectly required for appropriate NCC survival.
T14273 1647-1650 PRP$ denotes Our
T14274 1659-1666 NNS denotes results
T14275 1651-1658 JJ denotes present
T14276 1667-1674 VBP denotes suggest
T14277 1675-1679 IN denotes that
T14278 1794-1802 VBZ denotes mediates
T14279 1680-1685 IN denotes while
T14280 1735-1743 VBN denotes mediated
T14281 1686-1689 NN denotes TGF
T14282 1690-1691 NN denotes β
T14283 1689-1690 HYPH denotes -
T14284 1692-1701 NN denotes signaling
T14285 1702-1704 IN denotes in
T14286 1705-1712 JJ denotes cardiac
T14287 1713-1717 NNS denotes NCCs
T14288 1718-1720 VBZ denotes is
T14289 1721-1734 RB denotes predominantly
T14290 1744-1747 IN denotes via
T14291 1748-1751 DT denotes the
T14292 1775-1782 NN denotes complex
T14293 1752-1756 NN denotes ALK5
T14294 1761-1765 NN denotes βRII
T14295 1756-1757 HYPH denotes /
T14296 1757-1760 NN denotes TGF
T14297 1760-1761 HYPH denotes -
T14298 1766-1774 NN denotes receptor
T14299 1782-1784 , denotes ,
T14300 1784-1788 NN denotes ALK5
T14301 1789-1793 RB denotes also
T14302 1803-1812 NN denotes signaling
T14303 1813-1815 IN denotes of
T14304 1816-1821 JJ denotes other
T14305 1830-1837 NNS denotes ligands
T14306 1822-1829 JJ denotes related
T14307 1837-1839 , denotes ,
T14308 1839-1844 WDT denotes which
T14309 1879-1887 VBN denotes required
T14310 1845-1848 VBP denotes are
T14311 1849-1855 CC denotes either
T14312 1856-1864 RB denotes directly
T14313 1865-1867 CC denotes or
T14314 1868-1878 RB denotes indirectly
T14315 1888-1891 IN denotes for
T14316 1892-1903 JJ denotes appropriate
T14317 1908-1916 NN denotes survival
T14318 1904-1907 NN denotes NCC
T14319 1916-1917 . denotes .
T14320 1917-2074 sentence denotes In fact, it has been shown that, besides TGF-βRII, ALK5 can also form a complex with the Activin type IIB receptor to activate downstream Smads 2/3 [18,31].
T14321 1918-1920 IN denotes In
T14322 1939-1944 VBN denotes shown
T14323 1921-1925 NN denotes fact
T14324 1925-1927 , denotes ,
T14325 1927-1929 PRP denotes it
T14326 1930-1933 VBZ denotes has
T14327 1934-1938 VBN denotes been
T14328 1945-1949 IN denotes that
T14329 1983-1987 VB denotes form
T14330 1949-1951 , denotes ,
T14331 1951-1958 IN denotes besides
T14332 1959-1962 NN denotes TGF
T14333 1963-1967 NN denotes βRII
T14334 1962-1963 HYPH denotes -
T14335 1967-1969 , denotes ,
T14336 1969-1973 NN denotes ALK5
T14337 1974-1977 MD denotes can
T14338 1978-1982 RB denotes also
T14339 1988-1989 DT denotes a
T14340 1990-1997 NN denotes complex
T14341 1998-2002 IN denotes with
T14342 2003-2006 DT denotes the
T14343 2024-2032 NN denotes receptor
T14344 2007-2014 NN denotes Activin
T14345 2015-2019 NN denotes type
T14346 2020-2023 NN denotes IIB
T14347 2033-2035 TO denotes to
T14348 2036-2044 VB denotes activate
T14349 2045-2055 JJ denotes downstream
T14350 2056-2061 NNS denotes Smads
T14351 2062-2063 CD denotes 2
T14352 2063-2064 HYPH denotes /
T14353 2064-2065 CD denotes 3
T14354 2066-2067 -LRB- denotes [
T14355 2070-2072 CD denotes 31
T14356 2067-2069 CD denotes 18
T14357 2069-2070 , denotes ,
T14358 2072-2073 -RRB- denotes ]
T14359 2073-2074 . denotes .
T14360 2074-2231 sentence denotes Furthermore, a subset of TGF-β-related growth and differentiation factors (GDFs), e.g., GDF8, GDF9, GDF11 and GDF15 could induce these events [17,18,32,33].
T14361 2075-2086 RB denotes Furthermore
T14362 2197-2203 VB denotes induce
T14363 2086-2088 , denotes ,
T14364 2088-2089 DT denotes a
T14365 2090-2096 NN denotes subset
T14366 2097-2099 IN denotes of
T14367 2100-2103 NN denotes TGF
T14368 2104-2105 NN denotes β
T14369 2103-2104 HYPH denotes -
T14370 2106-2113 VBN denotes related
T14371 2105-2106 HYPH denotes -
T14372 2141-2148 NNS denotes factors
T14373 2114-2120 NN denotes growth
T14374 2121-2124 CC denotes and
T14375 2125-2140 NN denotes differentiation
T14376 2149-2150 -LRB- denotes (
T14377 2150-2154 NNS denotes GDFs
T14378 2154-2155 -RRB- denotes )
T14379 2155-2157 , denotes ,
T14380 2157-2161 FW denotes e.g.
T14381 2163-2167 NN denotes GDF8
T14382 2161-2163 , denotes ,
T14383 2167-2169 , denotes ,
T14384 2169-2173 NN denotes GDF9
T14385 2173-2175 , denotes ,
T14386 2175-2180 NN denotes GDF11
T14387 2181-2184 CC denotes and
T14388 2185-2190 NN denotes GDF15
T14389 2191-2196 MD denotes could
T14390 2204-2209 DT denotes these
T14391 2210-2216 NNS denotes events
T14392 2217-2218 -LRB- denotes [
T14393 2227-2229 CD denotes 33
T14394 2218-2220 CD denotes 17
T14395 2220-2221 , denotes ,
T14396 2221-2223 CD denotes 18
T14397 2223-2224 , denotes ,
T14398 2224-2226 CD denotes 32
T14399 2226-2227 , denotes ,
T14400 2229-2230 -RRB- denotes ]
T14401 2230-2231 . denotes .
T14402 2231-2555 sentence denotes Although relevant Gdfs 8, 9 11 and 15 are not expressed in the developing heart, nor do the mice deficient in these Gdfs display developmental cardiac defects, we cannot exclude the possibility that circulating GDFs, perhaps in concert with TGF-βs may contribute to NCC survival during cardiac and pharyngeal morphogenesis.
T14403 2232-2240 IN denotes Although
T14404 2353-2360 VB denotes display
T14405 2241-2249 JJ denotes relevant
T14406 2255-2256 CD denotes 8
T14407 2250-2254 NNS denotes Gdfs
T14408 2278-2287 VBN denotes expressed
T14409 2256-2258 , denotes ,
T14410 2258-2259 CD denotes 9
T14411 2260-2262 CD denotes 11
T14412 2263-2266 CC denotes and
T14413 2267-2269 CD denotes 15
T14414 2270-2273 VBP denotes are
T14415 2274-2277 RB denotes not
T14416 2288-2290 IN denotes in
T14417 2291-2294 DT denotes the
T14418 2306-2311 NN denotes heart
T14419 2295-2305 VBG denotes developing
T14420 2311-2313 , denotes ,
T14421 2313-2316 CC denotes nor
T14422 2317-2319 VBP denotes do
T14423 2320-2323 DT denotes the
T14424 2324-2328 NNS denotes mice
T14425 2329-2338 JJ denotes deficient
T14426 2339-2341 IN denotes in
T14427 2342-2347 DT denotes these
T14428 2348-2352 NNS denotes Gdfs
T14429 2402-2409 VB denotes exclude
T14430 2361-2374 JJ denotes developmental
T14431 2383-2390 NNS denotes defects
T14432 2375-2382 JJ denotes cardiac
T14433 2390-2392 , denotes ,
T14434 2392-2394 PRP denotes we
T14435 2395-2398 MD denotes can
T14436 2398-2401 RB denotes not
T14437 2410-2413 DT denotes the
T14438 2414-2425 NN denotes possibility
T14439 2426-2430 IN denotes that
T14440 2484-2494 VB denotes contribute
T14441 2431-2442 VBG denotes circulating
T14442 2443-2447 NNS denotes GDFs
T14443 2447-2449 , denotes ,
T14444 2449-2456 RB denotes perhaps
T14445 2457-2459 IN denotes in
T14446 2460-2467 NN denotes concert
T14447 2468-2472 IN denotes with
T14448 2473-2476 NNS denotes TGF
T14449 2477-2479 NNS denotes βs
T14450 2476-2477 HYPH denotes -
T14451 2480-2483 MD denotes may
T14452 2495-2497 IN denotes to
T14453 2498-2501 NN denotes NCC
T14454 2502-2510 NN denotes survival
T14455 2511-2517 IN denotes during
T14456 2518-2525 JJ denotes cardiac
T14457 2541-2554 NN denotes morphogenesis
T14458 2526-2529 CC denotes and
T14459 2530-2540 JJ denotes pharyngeal
T14460 2554-2555 . denotes .
T14461 2555-2688 sentence denotes We specifically studied apoptosis at the level of the aortic sac, where the AP-septum forms between the origins of 4th and 6th PAAs.
T14462 2556-2558 PRP denotes We
T14463 2572-2579 VBD denotes studied
T14464 2559-2571 RB denotes specifically
T14465 2580-2589 NN denotes apoptosis
T14466 2590-2592 IN denotes at
T14467 2593-2596 DT denotes the
T14468 2597-2602 NN denotes level
T14469 2603-2605 IN denotes of
T14470 2606-2609 DT denotes the
T14471 2617-2620 NN denotes sac
T14472 2610-2616 JJ denotes aortic
T14473 2620-2622 , denotes ,
T14474 2622-2627 WRB denotes where
T14475 2642-2647 VBZ denotes forms
T14476 2628-2631 DT denotes the
T14477 2635-2641 NN denotes septum
T14478 2632-2634 NN denotes AP
T14479 2634-2635 HYPH denotes -
T14480 2648-2655 IN denotes between
T14481 2656-2659 DT denotes the
T14482 2660-2667 NNS denotes origins
T14483 2668-2670 IN denotes of
T14484 2671-2674 JJ denotes 4th
T14485 2683-2687 NNS denotes PAAs
T14486 2675-2678 CC denotes and
T14487 2679-2682 JJ denotes 6th
T14488 2687-2688 . denotes .
T14489 2688-2931 sentence denotes Already at E10.5, we could see intense apoptosis among the postmigratory NCCs in the mesenchyme surrounding the aortic sac at the site where the prospective AP septum forms, i.e., this cell death precedes the AP septal defect seen in mutants.
T14490 2689-2696 RB denotes Already
T14491 2716-2719 VB denotes see
T14492 2697-2699 IN denotes at
T14493 2700-2705 NN denotes E10.5
T14494 2705-2707 , denotes ,
T14495 2707-2709 PRP denotes we
T14496 2710-2715 MD denotes could
T14497 2885-2893 VBZ denotes precedes
T14498 2720-2727 JJ denotes intense
T14499 2728-2737 NN denotes apoptosis
T14500 2738-2743 IN denotes among
T14501 2744-2747 DT denotes the
T14502 2762-2766 NNS denotes NCCs
T14503 2748-2761 JJ denotes postmigratory
T14504 2767-2769 IN denotes in
T14505 2770-2773 DT denotes the
T14506 2774-2784 NN denotes mesenchyme
T14507 2785-2796 VBG denotes surrounding
T14508 2797-2800 DT denotes the
T14509 2808-2811 NN denotes sac
T14510 2801-2807 JJ denotes aortic
T14511 2812-2814 IN denotes at
T14512 2815-2818 DT denotes the
T14513 2819-2823 NN denotes site
T14514 2824-2829 WRB denotes where
T14515 2856-2861 VBZ denotes forms
T14516 2830-2833 DT denotes the
T14517 2849-2855 NN denotes septum
T14518 2834-2845 JJ denotes prospective
T14519 2846-2848 NN denotes AP
T14520 2861-2863 , denotes ,
T14521 2863-2867 FW denotes i.e.
T14522 2867-2869 , denotes ,
T14523 2869-2873 DT denotes this
T14524 2879-2884 NN denotes death
T14525 2874-2878 NN denotes cell
T14526 2894-2897 DT denotes the
T14527 2908-2914 NN denotes defect
T14528 2898-2900 NN denotes AP
T14529 2901-2907 JJ denotes septal
T14530 2915-2919 VBN denotes seen
T14531 2920-2922 IN denotes in
T14532 2923-2930 NNS denotes mutants
T14533 2930-2931 . denotes .
T14534 2931-3131 sentence denotes Although some NC-derived cells appeared to be differentiating to smooth muscle cells in the OFT (Fig. 6), we could never detect the AP septum forming in Alk5/Wnt1-Cre mutants between E10.5 and E11.5.
T14535 2932-2940 IN denotes Although
T14536 2963-2971 VBD denotes appeared
T14537 2941-2945 DT denotes some
T14538 2957-2962 NNS denotes cells
T14539 2946-2948 NN denotes NC
T14540 2949-2956 VBN denotes derived
T14541 2948-2949 HYPH denotes -
T14542 3053-3059 VB denotes detect
T14543 2972-2974 TO denotes to
T14544 2978-2993 VBG denotes differentiating
T14545 2975-2977 VB denotes be
T14546 2994-2996 IN denotes to
T14547 2997-3003 JJ denotes smooth
T14548 3011-3016 NNS denotes cells
T14549 3004-3010 NN denotes muscle
T14550 3017-3019 IN denotes in
T14551 3020-3023 DT denotes the
T14552 3024-3027 NN denotes OFT
T14553 3028-3029 -LRB- denotes (
T14554 3029-3033 NN denotes Fig.
T14555 3034-3035 CD denotes 6
T14556 3035-3036 -RRB- denotes )
T14557 3036-3038 , denotes ,
T14558 3038-3040 PRP denotes we
T14559 3041-3046 MD denotes could
T14560 3047-3052 RB denotes never
T14561 3060-3063 DT denotes the
T14562 3067-3073 NN denotes septum
T14563 3064-3066 NN denotes AP
T14564 3074-3081 VBG denotes forming
T14565 3082-3084 IN denotes in
T14566 3085-3089 NN denotes Alk5
T14567 3095-3098 NN denotes Cre
T14568 3089-3090 HYPH denotes /
T14569 3090-3094 NN denotes Wnt1
T14570 3094-3095 HYPH denotes -
T14571 3099-3106 NNS denotes mutants
T14572 3107-3114 IN denotes between
T14573 3115-3120 NN denotes E10.5
T14574 3121-3124 CC denotes and
T14575 3125-3130 NN denotes E11.5
T14576 3130-3131 . denotes .
T14577 3131-3239 sentence denotes These findings suggest that the pool of cells forming the AP septum is severely affected by the cell death.
T14578 3132-3137 DT denotes These
T14579 3138-3146 NNS denotes findings
T14580 3147-3154 VBP denotes suggest
T14581 3155-3159 IN denotes that
T14582 3212-3220 VBN denotes affected
T14583 3160-3163 DT denotes the
T14584 3164-3168 NN denotes pool
T14585 3169-3171 IN denotes of
T14586 3172-3177 NNS denotes cells
T14587 3178-3185 VBG denotes forming
T14588 3186-3189 DT denotes the
T14589 3193-3199 NN denotes septum
T14590 3190-3192 NN denotes AP
T14591 3200-3202 VBZ denotes is
T14592 3203-3211 RB denotes severely
T14593 3221-3223 IN denotes by
T14594 3224-3227 DT denotes the
T14595 3233-3238 NN denotes death
T14596 3228-3232 NN denotes cell
T14597 3238-3239 . denotes .
T14598 3239-3375 sentence denotes Moreover, it is likely that these cells forming the AP-septum die the before majority of them can differentiate to smooth muscle cells.
T14599 3240-3248 RB denotes Moreover
T14600 3253-3255 VBZ denotes is
T14601 3248-3250 , denotes ,
T14602 3250-3252 PRP denotes it
T14603 3256-3262 JJ denotes likely
T14604 3263-3267 IN denotes that
T14605 3302-3305 VBP denotes die
T14606 3268-3273 DT denotes these
T14607 3274-3279 NNS denotes cells
T14608 3280-3287 VBG denotes forming
T14609 3288-3291 DT denotes the
T14610 3295-3301 NN denotes septum
T14611 3292-3294 NN denotes AP
T14612 3294-3295 HYPH denotes -
T14613 3306-3309 DT denotes the
T14614 3310-3316 IN denotes before
T14615 3338-3351 VB denotes differentiate
T14616 3317-3325 NN denotes majority
T14617 3326-3328 IN denotes of
T14618 3329-3333 PRP denotes them
T14619 3334-3337 MD denotes can
T14620 3352-3354 IN denotes to
T14621 3355-3361 JJ denotes smooth
T14622 3369-3374 NNS denotes cells
T14623 3362-3368 NN denotes muscle
T14624 3374-3375 . denotes .
T14625 3375-3510 sentence denotes Several in vitro studies have suggested an indispensable role for TGF-β-signaling in differentiation of NCCs into smooth muscle cells.
T14626 3376-3383 JJ denotes Several
T14627 3393-3400 NNS denotes studies
T14628 3384-3386 FW denotes in
T14629 3387-3392 FW denotes vitro
T14630 3406-3415 VBN denotes suggested
T14631 3401-3405 VBP denotes have
T14632 3416-3418 DT denotes an
T14633 3433-3437 NN denotes role
T14634 3419-3432 JJ denotes indispensable
T14635 3438-3441 IN denotes for
T14636 3442-3445 NN denotes TGF
T14637 3446-3447 NN denotes β
T14638 3445-3446 HYPH denotes -
T14639 3447-3448 HYPH denotes -
T14640 3448-3457 VBG denotes signaling
T14641 3458-3460 IN denotes in
T14642 3461-3476 NN denotes differentiation
T14643 3477-3479 IN denotes of
T14644 3480-3484 NNS denotes NCCs
T14645 3485-3489 IN denotes into
T14646 3490-3496 JJ denotes smooth
T14647 3497-3503 NN denotes muscle
T14648 3504-3509 NNS denotes cells
T14649 3509-3510 . denotes .
T14650 3510-3734 sentence denotes Moreover, a recent in vivo study suggested that mice lacking Tgfbr2 in CNCCs display defective NCC differentiation into αSMA-positive cells in the AP septum [9], although this result was later disputed by another study [8].
T14651 3511-3519 RB denotes Moreover
T14652 3544-3553 VBD denotes suggested
T14653 3519-3521 , denotes ,
T14654 3521-3522 DT denotes a
T14655 3538-3543 NN denotes study
T14656 3523-3529 JJ denotes recent
T14657 3530-3532 FW denotes in
T14658 3533-3537 FW denotes vivo
T14659 3554-3558 IN denotes that
T14660 3588-3595 VBP denotes display
T14661 3559-3563 NNS denotes mice
T14662 3564-3571 VBG denotes lacking
T14663 3572-3578 NN denotes Tgfbr2
T14664 3579-3581 IN denotes in
T14665 3582-3587 NNS denotes CNCCs
T14666 3596-3605 JJ denotes defective
T14667 3610-3625 NN denotes differentiation
T14668 3606-3609 NN denotes NCC
T14669 3626-3630 IN denotes into
T14670 3631-3635 NN denotes αSMA
T14671 3636-3644 JJ denotes positive
T14672 3635-3636 HYPH denotes -
T14673 3645-3650 NNS denotes cells
T14674 3651-3653 IN denotes in
T14675 3654-3657 DT denotes the
T14676 3661-3667 NN denotes septum
T14677 3658-3660 NN denotes AP
T14678 3668-3669 -LRB- denotes [
T14679 3669-3670 CD denotes 9
T14680 3670-3671 -RRB- denotes ]
T14681 3671-3673 , denotes ,
T14682 3673-3681 IN denotes although
T14683 3704-3712 VBN denotes disputed
T14684 3682-3686 DT denotes this
T14685 3687-3693 NN denotes result
T14686 3694-3697 VBD denotes was
T14687 3698-3703 RB denotes later
T14688 3713-3715 IN denotes by
T14689 3716-3723 DT denotes another
T14690 3724-3729 NN denotes study
T14691 3730-3731 -LRB- denotes [
T14692 3731-3732 CD denotes 8
T14693 3732-3733 -RRB- denotes ]
T14694 3733-3734 . denotes .
T14695 3734-3896 sentence denotes Our immunohistochemical staining of αSMA in the OFT unequivocally demonstrated that signaling via ALK5 is not required for smooth muscle differentiation in vivo.
T14696 3735-3738 PRP$ denotes Our
T14697 3759-3767 NN denotes staining
T14698 3739-3758 JJ denotes immunohistochemical
T14699 3801-3813 VBD denotes demonstrated
T14700 3768-3770 IN denotes of
T14701 3771-3775 NN denotes αSMA
T14702 3776-3778 IN denotes in
T14703 3779-3782 DT denotes the
T14704 3783-3786 NN denotes OFT
T14705 3787-3800 RB denotes unequivocally
T14706 3814-3818 IN denotes that
T14707 3845-3853 VBN denotes required
T14708 3819-3828 NN denotes signaling
T14709 3829-3832 IN denotes via
T14710 3833-3837 NN denotes ALK5
T14711 3838-3840 VBZ denotes is
T14712 3841-3844 RB denotes not
T14713 3854-3857 IN denotes for
T14714 3858-3864 JJ denotes smooth
T14715 3865-3871 NN denotes muscle
T14716 3872-3887 NN denotes differentiation
T14717 3888-3890 FW denotes in
T14718 3891-3895 FW denotes vivo
T14719 3895-3896 . denotes .
T14720 3896-4176 sentence denotes Moreover, it has been suggested that deletion of Tgfbr2 in NCCs leads to other phenotypic features reminiscent of those seen in the velocardiofacial/DiGeorge syndrome (VCF/DGS) [9] caused by a deletion of the so called DiGeorge critical region (DGCR) on chromosome 22q11 [34,35].
T14721 3897-3905 RB denotes Moreover
T14722 3919-3928 VBN denotes suggested
T14723 3905-3907 , denotes ,
T14724 3907-3909 PRP denotes it
T14725 3910-3913 VBZ denotes has
T14726 3914-3918 VBN denotes been
T14727 3929-3933 IN denotes that
T14728 3961-3966 VBZ denotes leads
T14729 3934-3942 NN denotes deletion
T14730 3943-3945 IN denotes of
T14731 3946-3952 NN denotes Tgfbr2
T14732 3953-3955 IN denotes in
T14733 3956-3960 NNS denotes NCCs
T14734 3967-3969 IN denotes to
T14735 3970-3975 JJ denotes other
T14736 3987-3995 NNS denotes features
T14737 3976-3986 JJ denotes phenotypic
T14738 3996-4007 JJ denotes reminiscent
T14739 4008-4010 IN denotes of
T14740 4011-4016 DT denotes those
T14741 4017-4021 VBN denotes seen
T14742 4022-4024 IN denotes in
T14743 4025-4028 DT denotes the
T14744 4055-4063 NN denotes syndrome
T14745 4029-4045 JJ denotes velocardiofacial
T14746 4046-4054 NN denotes DiGeorge
T14747 4045-4046 HYPH denotes /
T14748 4064-4065 -LRB- denotes (
T14749 4065-4068 NN denotes VCF
T14750 4069-4072 NN denotes DGS
T14751 4068-4069 HYPH denotes /
T14752 4072-4073 -RRB- denotes )
T14753 4074-4075 -LRB- denotes [
T14754 4075-4076 CD denotes 9
T14755 4076-4077 -RRB- denotes ]
T14756 4078-4084 VBN denotes caused
T14757 4085-4087 IN denotes by
T14758 4088-4089 DT denotes a
T14759 4090-4098 NN denotes deletion
T14760 4099-4101 IN denotes of
T14761 4102-4105 DT denotes the
T14762 4134-4140 NN denotes region
T14763 4106-4108 RB denotes so
T14764 4109-4115 VBN denotes called
T14765 4116-4124 NNP denotes DiGeorge
T14766 4125-4133 JJ denotes critical
T14767 4141-4142 -LRB- denotes (
T14768 4142-4146 NN denotes DGCR
T14769 4146-4147 -RRB- denotes )
T14770 4148-4150 IN denotes on
T14771 4151-4161 NN denotes chromosome
T14772 4162-4167 NN denotes 22q11
T14773 4168-4169 -LRB- denotes [
T14774 4172-4174 CD denotes 35
T14775 4169-4171 CD denotes 34
T14776 4171-4172 , denotes ,
T14777 4174-4175 -RRB- denotes ]
T14778 4175-4176 . denotes .
T14779 4176-4437 sentence denotes Our present results suggest that although many of the observed phenotypes seen in Alk5/Wnt1-Cre mutants superficially resemble those seen in VCF/DGS, a detailed examination shows that the NC-specific abrogation of Alk5 does not lead to VCF/DGS-like phenotypes.
T14780 4177-4180 PRP$ denotes Our
T14781 4189-4196 NNS denotes results
T14782 4181-4188 JJ denotes present
T14783 4197-4204 VBP denotes suggest
T14784 4205-4209 IN denotes that
T14785 4350-4355 VBZ denotes shows
T14786 4210-4218 IN denotes although
T14787 4295-4303 VBP denotes resemble
T14788 4219-4223 JJ denotes many
T14789 4224-4226 IN denotes of
T14790 4227-4230 DT denotes the
T14791 4240-4250 NNS denotes phenotypes
T14792 4231-4239 VBN denotes observed
T14793 4251-4255 VBN denotes seen
T14794 4256-4258 IN denotes in
T14795 4259-4263 NN denotes Alk5
T14796 4269-4272 NN denotes Cre
T14797 4263-4264 HYPH denotes /
T14798 4264-4268 NN denotes Wnt1
T14799 4268-4269 HYPH denotes -
T14800 4273-4280 NNS denotes mutants
T14801 4281-4294 RB denotes superficially
T14802 4304-4309 DT denotes those
T14803 4310-4314 VBN denotes seen
T14804 4315-4317 IN denotes in
T14805 4318-4321 NN denotes VCF
T14806 4322-4325 NN denotes DGS
T14807 4321-4322 HYPH denotes /
T14808 4325-4327 , denotes ,
T14809 4327-4328 DT denotes a
T14810 4338-4349 NN denotes examination
T14811 4329-4337 VBN denotes detailed
T14812 4356-4360 IN denotes that
T14813 4405-4409 VB denotes lead
T14814 4361-4364 DT denotes the
T14815 4377-4387 NN denotes abrogation
T14816 4365-4367 NN denotes NC
T14817 4368-4376 JJ denotes specific
T14818 4367-4368 HYPH denotes -
T14819 4388-4390 IN denotes of
T14820 4391-4395 NN denotes Alk5
T14821 4396-4400 VBZ denotes does
T14822 4401-4404 RB denotes not
T14823 4410-4412 IN denotes to
T14824 4413-4416 NN denotes VCF
T14825 4417-4420 NN denotes DGS
T14826 4416-4417 HYPH denotes /
T14827 4421-4425 JJ denotes like
T14828 4420-4421 HYPH denotes -
T14829 4426-4436 NNS denotes phenotypes
T14830 4436-4437 . denotes .
T14831 4437-4718 sentence denotes Firstly, while the pharyngeal organ migration fails in Alk5/Wnt1-Cre mutants, perhaps as a result of increased mesenchymal cell death in the pharyngeal region, both the thymus, thyroid and parathyroid seem to develop relatively normally on the histological level in these mutants.
T14832 4438-4445 RB denotes Firstly
T14833 4639-4643 VBP denotes seem
T14834 4445-4447 , denotes ,
T14835 4447-4452 IN denotes while
T14836 4484-4489 VBZ denotes fails
T14837 4453-4456 DT denotes the
T14838 4474-4483 NN denotes migration
T14839 4457-4467 JJ denotes pharyngeal
T14840 4468-4473 NN denotes organ
T14841 4490-4492 IN denotes in
T14842 4493-4497 NN denotes Alk5
T14843 4503-4506 NN denotes Cre
T14844 4497-4498 HYPH denotes /
T14845 4498-4502 NN denotes Wnt1
T14846 4502-4503 HYPH denotes -
T14847 4507-4514 NNS denotes mutants
T14848 4514-4516 , denotes ,
T14849 4516-4523 RB denotes perhaps
T14850 4524-4526 IN denotes as
T14851 4527-4528 DT denotes a
T14852 4529-4535 NN denotes result
T14853 4536-4538 IN denotes of
T14854 4539-4548 VBN denotes increased
T14855 4566-4571 NN denotes death
T14856 4549-4560 JJ denotes mesenchymal
T14857 4561-4565 NN denotes cell
T14858 4572-4574 IN denotes in
T14859 4575-4578 DT denotes the
T14860 4590-4596 NN denotes region
T14861 4579-4589 JJ denotes pharyngeal
T14862 4596-4598 , denotes ,
T14863 4598-4602 CC denotes both
T14864 4607-4613 NN denotes thymus
T14865 4603-4606 DT denotes the
T14866 4613-4615 , denotes ,
T14867 4615-4622 NN denotes thyroid
T14868 4623-4626 CC denotes and
T14869 4627-4638 NN denotes parathyroid
T14870 4644-4646 TO denotes to
T14871 4647-4654 VB denotes develop
T14872 4655-4665 RB denotes relatively
T14873 4666-4674 RB denotes normally
T14874 4675-4677 IN denotes on
T14875 4678-4681 DT denotes the
T14876 4695-4700 NN denotes level
T14877 4682-4694 JJ denotes histological
T14878 4701-4703 IN denotes in
T14879 4704-4709 DT denotes these
T14880 4710-4717 NNS denotes mutants
T14881 4717-4718 . denotes .
T14882 4718-5109 sentence denotes Secondly, the NCC death seen in Alk5 mutants affects a predominantly postmigratory population of NCCs, while genes located in the DGCR, i.e., Tbx1 and CrkL, control NCC survival earlier at E8.5-E10 by regulating proliferation of the secondary heart field (SHF), and endoderm expansion, which in turn provides survival signal for NCCs allowing them to populate the pharyngeal region [36-39].
T14883 4719-4727 RB denotes Secondly
T14884 4764-4771 VBZ denotes affects
T14885 4727-4729 , denotes ,
T14886 4729-4732 DT denotes the
T14887 4737-4742 NN denotes death
T14888 4733-4736 NN denotes NCC
T14889 4743-4747 VBN denotes seen
T14890 4748-4750 IN denotes in
T14891 4751-4755 NN denotes Alk5
T14892 4756-4763 NNS denotes mutants
T14893 4772-4773 DT denotes a
T14894 4802-4812 NN denotes population
T14895 4774-4787 RB denotes predominantly
T14896 4788-4801 JJ denotes postmigratory
T14897 4813-4815 IN denotes of
T14898 4816-4820 NNS denotes NCCs
T14899 4820-4822 , denotes ,
T14900 4822-4827 IN denotes while
T14901 4876-4883 VBP denotes control
T14902 4828-4833 NNS denotes genes
T14903 4834-4841 VBN denotes located
T14904 4842-4844 IN denotes in
T14905 4845-4848 DT denotes the
T14906 4849-4853 NN denotes DGCR
T14907 4853-4855 , denotes ,
T14908 4855-4859 FW denotes i.e.
T14909 4861-4865 NN denotes Tbx1
T14910 4859-4861 , denotes ,
T14911 4866-4869 CC denotes and
T14912 4870-4874 NN denotes CrkL
T14913 4874-4876 , denotes ,
T14914 4884-4887 NN denotes NCC
T14915 4888-4896 NN denotes survival
T14916 4897-4904 RB denotes earlier
T14917 4905-4907 IN denotes at
T14918 4908-4912 NN denotes E8.5
T14919 4912-4913 SYM denotes -
T14920 4913-4916 NN denotes E10
T14921 4917-4919 IN denotes by
T14922 4920-4930 VBG denotes regulating
T14923 4931-4944 NN denotes proliferation
T14924 4945-4947 IN denotes of
T14925 4948-4951 DT denotes the
T14926 4968-4973 NN denotes field
T14927 4952-4961 JJ denotes secondary
T14928 4962-4967 NN denotes heart
T14929 4974-4975 -LRB- denotes (
T14930 4975-4978 NN denotes SHF
T14931 4978-4979 -RRB- denotes )
T14932 4979-4981 , denotes ,
T14933 4981-4984 CC denotes and
T14934 4985-4993 NN denotes endoderm
T14935 4994-5003 NN denotes expansion
T14936 5003-5005 , denotes ,
T14937 5005-5010 WDT denotes which
T14938 5019-5027 VBZ denotes provides
T14939 5011-5013 IN denotes in
T14940 5014-5018 NN denotes turn
T14941 5028-5036 NN denotes survival
T14942 5037-5043 NN denotes signal
T14943 5044-5047 IN denotes for
T14944 5048-5052 NNS denotes NCCs
T14945 5053-5061 VBG denotes allowing
T14946 5062-5066 PRP denotes them
T14947 5067-5069 TO denotes to
T14948 5070-5078 VB denotes populate
T14949 5079-5082 DT denotes the
T14950 5094-5100 NN denotes region
T14951 5083-5093 JJ denotes pharyngeal
T14952 5101-5102 -LRB- denotes [
T14953 5102-5104 CD denotes 36
T14954 5104-5105 SYM denotes -
T14955 5105-5107 CD denotes 39
T14956 5107-5108 -RRB- denotes ]
T14957 5108-5109 . denotes .
T14958 5109-5245 sentence denotes NCC ablation in the chick has been shown to lead to PTA and to a failure of addition of myocardium from the secondary heart field [40].
T14959 5110-5113 NN denotes NCC
T14960 5114-5122 NN denotes ablation
T14961 5145-5150 VBN denotes shown
T14962 5123-5125 IN denotes in
T14963 5126-5129 DT denotes the
T14964 5130-5135 NN denotes chick
T14965 5136-5139 VBZ denotes has
T14966 5140-5144 VBN denotes been
T14967 5151-5153 TO denotes to
T14968 5154-5158 VB denotes lead
T14969 5159-5161 IN denotes to
T14970 5162-5165 NN denotes PTA
T14971 5166-5169 CC denotes and
T14972 5170-5172 IN denotes to
T14973 5173-5174 DT denotes a
T14974 5175-5182 NN denotes failure
T14975 5183-5185 IN denotes of
T14976 5186-5194 NN denotes addition
T14977 5195-5197 IN denotes of
T14978 5198-5208 NN denotes myocardium
T14979 5209-5213 IN denotes from
T14980 5214-5217 DT denotes the
T14981 5234-5239 NN denotes field
T14982 5218-5227 JJ denotes secondary
T14983 5228-5233 NN denotes heart
T14984 5240-5241 -LRB- denotes [
T14985 5241-5243 CD denotes 40
T14986 5243-5244 -RRB- denotes ]
T14987 5244-5245 . denotes .
T14988 5245-5484 sentence denotes It was suggested that the defective migration of cells from the secondary heart field to the OFT in turn resulted in shortening and inappropriate rotation of the OFT, leading to mal-alignment of the arterial pole with the ventricles [41].
T14989 5246-5248 PRP denotes It
T14990 5253-5262 VBN denotes suggested
T14991 5249-5252 VBD denotes was
T14992 5263-5267 IN denotes that
T14993 5351-5359 VBD denotes resulted
T14994 5268-5271 DT denotes the
T14995 5282-5291 NN denotes migration
T14996 5272-5281 JJ denotes defective
T14997 5292-5294 IN denotes of
T14998 5295-5300 NNS denotes cells
T14999 5301-5305 IN denotes from
T15000 5306-5309 DT denotes the
T15001 5326-5331 NN denotes field
T15002 5310-5319 JJ denotes secondary
T15003 5320-5325 NN denotes heart
T15004 5332-5334 IN denotes to
T15005 5335-5338 DT denotes the
T15006 5339-5342 NN denotes OFT
T15007 5343-5345 IN denotes in
T15008 5346-5350 NN denotes turn
T15009 5360-5362 IN denotes in
T15010 5363-5373 NN denotes shortening
T15011 5374-5377 CC denotes and
T15012 5378-5391 JJ denotes inappropriate
T15013 5392-5400 NN denotes rotation
T15014 5401-5403 IN denotes of
T15015 5404-5407 DT denotes the
T15016 5408-5411 NN denotes OFT
T15017 5411-5413 , denotes ,
T15018 5413-5420 VBG denotes leading
T15019 5421-5423 IN denotes to
T15020 5424-5437 NN denotes mal-alignment
T15021 5438-5440 IN denotes of
T15022 5441-5444 DT denotes the
T15023 5454-5458 NN denotes pole
T15024 5445-5453 JJ denotes arterial
T15025 5459-5463 IN denotes with
T15026 5464-5467 DT denotes the
T15027 5468-5478 NNS denotes ventricles
T15028 5479-5480 -LRB- denotes [
T15029 5480-5482 CD denotes 41
T15030 5482-5483 -RRB- denotes ]
T15031 5483-5484 . denotes .
T15032 5484-5775 sentence denotes While the detected OFT phenotype in Alk5/Wnt1-Cre mutants shared many similarities with that seen in the chick NC ablation models, e.g., PTA and the hypoplastic aortic sac, our current results suggest that the secondary heart field is not severely affected in Alk5 mutants (data not shown).
T15033 5485-5490 IN denotes While
T15034 5543-5549 VBD denotes shared
T15035 5491-5494 DT denotes the
T15036 5508-5517 NN denotes phenotype
T15037 5495-5503 VBN denotes detected
T15038 5504-5507 NN denotes OFT
T15039 5518-5520 IN denotes in
T15040 5521-5525 NN denotes Alk5
T15041 5531-5534 NN denotes Cre
T15042 5525-5526 HYPH denotes /
T15043 5526-5530 NN denotes Wnt1
T15044 5530-5531 HYPH denotes -
T15045 5535-5542 NNS denotes mutants
T15046 5678-5685 VBP denotes suggest
T15047 5550-5554 JJ denotes many
T15048 5555-5567 NNS denotes similarities
T15049 5568-5572 IN denotes with
T15050 5573-5577 DT denotes that
T15051 5578-5582 VBN denotes seen
T15052 5583-5585 IN denotes in
T15053 5586-5589 DT denotes the
T15054 5608-5614 NNS denotes models
T15055 5590-5595 NN denotes chick
T15056 5596-5598 NN denotes NC
T15057 5599-5607 NN denotes ablation
T15058 5614-5616 , denotes ,
T15059 5616-5620 FW denotes e.g.
T15060 5622-5625 NN denotes PTA
T15061 5620-5622 , denotes ,
T15062 5626-5629 CC denotes and
T15063 5630-5633 DT denotes the
T15064 5653-5656 NN denotes sac
T15065 5634-5645 JJ denotes hypoplastic
T15066 5646-5652 JJ denotes aortic
T15067 5656-5658 , denotes ,
T15068 5658-5661 PRP$ denotes our
T15069 5670-5677 NNS denotes results
T15070 5662-5669 JJ denotes current
T15071 5686-5690 IN denotes that
T15072 5733-5741 VBN denotes affected
T15073 5691-5694 DT denotes the
T15074 5711-5716 NN denotes field
T15075 5695-5704 JJ denotes secondary
T15076 5705-5710 NN denotes heart
T15077 5717-5719 VBZ denotes is
T15078 5720-5723 RB denotes not
T15079 5724-5732 RB denotes severely
T15080 5742-5744 IN denotes in
T15081 5745-5749 NN denotes Alk5
T15082 5750-5757 NNS denotes mutants
T15083 5758-5759 -LRB- denotes (
T15084 5768-5773 VBN denotes shown
T15085 5759-5763 NNS denotes data
T15086 5764-5767 RB denotes not
T15087 5773-5774 -RRB- denotes )
T15088 5774-5775 . denotes .
T15089 5775-6012 sentence denotes Since we could not detect appropriate rotation of the OFT in neural crest-specific mutants of Alk5 or Alk2, it appears that cells derived from the NC, as well as those from the SHF, are mutually required for proper OFT rotation in mice.
T15090 5776-5781 IN denotes Since
T15091 5795-5801 VB denotes detect
T15092 5782-5784 PRP denotes we
T15093 5785-5790 MD denotes could
T15094 5791-5794 RB denotes not
T15095 5887-5894 VBZ denotes appears
T15096 5802-5813 JJ denotes appropriate
T15097 5814-5822 NN denotes rotation
T15098 5823-5825 IN denotes of
T15099 5826-5829 DT denotes the
T15100 5830-5833 NN denotes OFT
T15101 5834-5836 IN denotes in
T15102 5837-5843 JJ denotes neural
T15103 5844-5849 NN denotes crest
T15104 5850-5858 JJ denotes specific
T15105 5849-5850 HYPH denotes -
T15106 5859-5866 NNS denotes mutants
T15107 5867-5869 IN denotes of
T15108 5870-5874 NN denotes Alk5
T15109 5875-5877 CC denotes or
T15110 5878-5882 NN denotes Alk2
T15111 5882-5884 , denotes ,
T15112 5884-5886 PRP denotes it
T15113 5895-5899 IN denotes that
T15114 5971-5979 VBN denotes required
T15115 5900-5905 NNS denotes cells
T15116 5906-5913 VBN denotes derived
T15117 5914-5918 IN denotes from
T15118 5919-5922 DT denotes the
T15119 5923-5925 NN denotes NC
T15120 5925-5927 , denotes ,
T15121 5927-5929 RB denotes as
T15122 5935-5937 IN denotes as
T15123 5930-5934 RB denotes well
T15124 5938-5943 DT denotes those
T15125 5944-5948 IN denotes from
T15126 5949-5952 DT denotes the
T15127 5953-5956 NN denotes SHF
T15128 5956-5958 , denotes ,
T15129 5958-5961 VBP denotes are
T15130 5962-5970 RB denotes mutually
T15131 5980-5983 IN denotes for
T15132 5984-5990 JJ denotes proper
T15133 5995-6003 NN denotes rotation
T15134 5991-5994 NN denotes OFT
T15135 6004-6006 IN denotes in
T15136 6007-6011 NNS denotes mice
T15137 6011-6012 . denotes .
T15138 6012-6131 sentence denotes However, it appears that these two TGF-β/BMP type I receptors contribute to OFT rotation through different mechanisms.
T15139 6013-6020 RB denotes However
T15140 6025-6032 VBZ denotes appears
T15141 6020-6022 , denotes ,
T15142 6022-6024 PRP denotes it
T15143 6033-6037 IN denotes that
T15144 6075-6085 VBP denotes contribute
T15145 6038-6043 DT denotes these
T15146 6065-6074 NNS denotes receptors
T15147 6044-6047 CD denotes two
T15148 6048-6051 NN denotes TGF
T15149 6054-6057 NN denotes BMP
T15150 6051-6052 HYPH denotes -
T15151 6052-6053 NN denotes β
T15152 6053-6054 HYPH denotes /
T15153 6058-6062 NN denotes type
T15154 6063-6064 CD denotes I
T15155 6086-6088 IN denotes to
T15156 6089-6092 NN denotes OFT
T15157 6093-6101 NN denotes rotation
T15158 6102-6109 IN denotes through
T15159 6110-6119 JJ denotes different
T15160 6120-6130 NNS denotes mechanisms
T15161 6130-6131 . denotes .
T15162 6131-6359 sentence denotes In Alk5 mutants there is very little, if any, detectable septal mesenchyme present, and thus it could be argued that in these mutants OFT rotation fails due to a lack of penetration of septal prongs into the cushion mesenchyme.
T15163 6132-6134 IN denotes In
T15164 6154-6156 VBZ denotes is
T15165 6135-6139 NN denotes Alk5
T15166 6140-6147 NNS denotes mutants
T15167 6148-6153 EX denotes there
T15168 6157-6161 RB denotes very
T15169 6162-6168 JJ denotes little
T15170 6196-6206 NN denotes mesenchyme
T15171 6168-6170 , denotes ,
T15172 6173-6176 DT denotes any
T15173 6170-6172 IN denotes if
T15174 6176-6178 , denotes ,
T15175 6178-6188 JJ denotes detectable
T15176 6189-6195 JJ denotes septal
T15177 6207-6214 JJ denotes present
T15178 6214-6216 , denotes ,
T15179 6216-6219 CC denotes and
T15180 6220-6224 RB denotes thus
T15181 6237-6243 VBN denotes argued
T15182 6225-6227 PRP denotes it
T15183 6228-6233 MD denotes could
T15184 6234-6236 VB denotes be
T15185 6244-6248 IN denotes that
T15186 6279-6284 VBZ denotes fails
T15187 6249-6251 IN denotes in
T15188 6252-6257 DT denotes these
T15189 6258-6265 NNS denotes mutants
T15190 6266-6269 NN denotes OFT
T15191 6270-6278 NN denotes rotation
T15192 6285-6288 IN denotes due
T15193 6289-6291 IN denotes to
T15194 6292-6293 DT denotes a
T15195 6294-6298 NN denotes lack
T15196 6299-6301 IN denotes of
T15197 6302-6313 NN denotes penetration
T15198 6314-6316 IN denotes of
T15199 6317-6323 JJ denotes septal
T15200 6324-6330 NNS denotes prongs
T15201 6331-6335 IN denotes into
T15202 6336-6339 DT denotes the
T15203 6348-6358 NN denotes mesenchyme
T15204 6340-6347 NN denotes cushion
T15205 6358-6359 . denotes .
T15206 6359-6658 sentence denotes In contrast, in Alk2/Wnt1-Cre mutants a sizeable septal mesenchyme could be seen, still without any obvious looping of the aortic sac and truncal OFT, suggesting that the mere presence of the septal mesenchyme, without correct smooth muscle cell differentiation, is not sufficient for OFT rotation.
T15229 6460-6467 JJ denotes obvious
T15230 6476-6478 IN denotes of
T15231 6479-6482 DT denotes the
T15232 6490-6493 NN denotes sac
T15233 6483-6489 JJ denotes aortic
T15234 6494-6497 CC denotes and
T15235 6498-6505 JJ denotes truncal
T15236 6506-6509 NN denotes OFT
T15237 6509-6511 , denotes ,
T15238 6511-6521 VBG denotes suggesting
T15239 6522-6526 IN denotes that
T15240 6623-6625 VBZ denotes is
T15241 6527-6530 DT denotes the
T15242 6536-6544 NN denotes presence
T15243 6531-6535 JJ denotes mere
T15244 6545-6547 IN denotes of
T15245 6548-6551 DT denotes the
T15246 6559-6569 NN denotes mesenchyme
T15247 6552-6558 JJ denotes septal
T15248 6569-6571 , denotes ,
T15249 6571-6578 IN denotes without
T15250 6579-6586 JJ denotes correct
T15251 6606-6621 NN denotes differentiation
T15252 6587-6593 JJ denotes smooth
T15253 6594-6600 NN denotes muscle
T15254 6601-6605 NN denotes cell
T15255 6621-6623 , denotes ,
T15256 6626-6629 RB denotes not
T15257 6630-6640 JJ denotes sufficient
T15258 6641-6644 IN denotes for
T15259 6645-6648 NN denotes OFT
T15260 6649-6657 NN denotes rotation
T15261 6657-6658 . denotes .
T14255 1588-1593 NN denotes death
T15207 6360-6362 IN denotes In
T15208 6436-6440 VBN denotes seen
T15209 6363-6371 NN denotes contrast
T15210 6371-6373 , denotes ,
T15211 6373-6375 IN denotes in
T15212 6376-6380 NN denotes Alk2
T15213 6386-6389 NN denotes Cre
T15214 6380-6381 HYPH denotes /
T15215 6381-6385 NN denotes Wnt1
T15216 6385-6386 HYPH denotes -
T15217 6390-6397 NNS denotes mutants
T15218 6398-6399 DT denotes a
T15219 6416-6426 NN denotes mesenchyme
T15220 6400-6408 JJ denotes sizeable
T15221 6409-6415 JJ denotes septal
T15222 6427-6432 MD denotes could
T15223 6433-6435 VB denotes be
T15224 6440-6442 , denotes ,
T15225 6442-6447 RB denotes still
T15226 6448-6455 IN denotes without
T15227 6456-6459 DT denotes any
T15228 6468-6475 NN denotes looping
R3452 T13939 T13940 prep During,proven
R3453 T13941 T13942 det the,years
R3454 T13942 T13939 pobj years,During
R3455 T13943 T13942 amod last,years
R3456 T13944 T13942 amod few,years
R3457 T13945 T13946 det the,line
R3458 T13946 T13940 nsubj line,proven
R3459 T13947 T13948 compound Wnt1,Cre
R3460 T13948 T13950 npadvmod Cre,transgenic
R3461 T13949 T13948 punct -,Cre
R3462 T13950 T13946 amod transgenic,line
R3463 T13951 T13946 compound driver,line
R3464 T13952 T13940 aux has,proven
R3465 T13953 T13954 aux to,be
R3466 T13954 T13940 xcomp be,proven
R3467 T13955 T13956 det a,tool
R3468 T13956 T13954 attr tool,be
R3469 T13957 T13956 amod powerful,tool
R3470 T13958 T13956 prep for,tool
R3471 T13959 T13960 npadvmod tissue,specific
R3472 T13960 T13962 amod specific,deletion
R3473 T13961 T13960 punct -,specific
R3474 T13962 T13958 pobj deletion,for
R3475 T13963 T13962 compound gene,deletion
R3476 T13964 T13962 prep in,deletion
R3477 T13965 T13964 pobj NCCs,in
R3478 T13966 T13967 punct [,28
R3479 T13967 T13954 parataxis 28,be
R3480 T13968 T13967 nummod 12,28
R3481 T13969 T13967 punct ",",28
R3482 T13970 T13967 nummod 13,28
R3483 T13971 T13967 punct ",",28
R3484 T13972 T13967 nummod 27,28
R3485 T13973 T13967 punct ",",28
R3486 T13974 T13967 punct ],28
R3487 T13975 T13940 punct .,proven
R3488 T13977 T13978 advcl Using,shown
R3489 T13979 T13980 det this,approach
R3490 T13980 T13977 dobj approach,Using
R3491 T13981 T13978 punct ", ",shown
R3492 T13982 T13983 amod several,studies
R3493 T13983 T13978 nsubj studies,shown
R3494 T13984 T13978 aux have,shown
R3495 T13985 T13978 advmod independently,shown
R3496 T13986 T13987 mark that,leads
R3497 T13987 T13978 ccomp leads,shown
R3498 T13988 T13989 det the,deletion
R3499 T13989 T13987 nsubj deletion,leads
R3500 T13990 T13991 npadvmod NC,specific
R3501 T13991 T13989 amod specific,deletion
R3502 T13992 T13991 punct -,specific
R3503 T13993 T13989 prep of,deletion
R3504 T13994 T13995 det the,gene
R3505 T13995 T13993 pobj gene,of
R3506 T13996 T13995 compound Tgfbr2,gene
R3507 T13997 T13987 prep to,leads
R3508 T13998 T13999 det a,set
R3509 T13999 T13997 pobj set,to
R3510 T14000 T13999 amod distinct,set
R3511 T14001 T13999 prep of,set
R3512 T14002 T14003 amod calvarial,defects
R3513 T14003 T14001 pobj defects,of
R3514 T14004 T14002 punct ", ",calvarial
R3515 T14005 T14002 conj facial,calvarial
R3516 T14006 T14005 cc and,facial
R3517 T14007 T14005 conj cardiac,facial
R3518 T14008 T14009 punct [,29
R3519 T14009 T13978 parataxis 29,shown
R3520 T14010 T14009 nummod 8,29
R3521 T14011 T14009 punct ",",29
R3522 T14012 T14009 nummod 9,29
R3523 T14013 T14009 punct ",",29
R3524 T14014 T14009 nummod 20,29
R3525 T14015 T14009 punct ",",29
R3526 T14016 T14009 punct ],29
R3527 T14017 T13978 punct .,shown
R3528 T14019 T14020 advmod Interestingly,appear
R3529 T14021 T14020 punct ", ",appear
R3530 T14022 T14023 det these,defects
R3531 T14023 T14020 nsubj defects,appear
R3532 T14024 T14025 advmod quite,different
R3533 T14025 T14020 oprd different,appear
R3534 T14026 T14027 preconj both,in
R3535 T14027 T14020 prep in,appear
R3536 T14028 T14029 det the,regions
R3537 T14029 T14027 pobj regions,in
R3538 T14030 T14029 amod craniofacial,regions
R3539 T14031 T14030 cc and,craniofacial
R3540 T14032 T14030 conj pharyngeal,craniofacial
R3541 T14033 T14029 punct ", ",regions
R3542 T14034 T14029 prep including,regions
R3543 T14035 T14036 det the,heart
R3544 T14036 T14034 pobj heart,including
R3545 T14037 T14020 punct ", ",appear
R3546 T14038 T14039 advmod when,compared
R3547 T14039 T14020 advcl compared,appear
R3548 T14040 T14039 prep to,compared
R3549 T14041 T14042 det the,mutants
R3550 T14042 T14040 pobj mutants,to
R3551 T14043 T14042 amod corresponding,mutants
R3552 T14044 T14042 prep of,mutants
R3553 T14045 T14044 pobj Alk5,of
R3554 T14046 T14042 punct ", ",mutants
R3555 T14047 T14048 dep which,encodes
R3556 T14048 T14042 relcl encodes,mutants
R3557 T14049 T14050 det the,receptor
R3558 T14050 T14048 dobj receptor,encodes
R3559 T14051 T14052 nmod TGF,β
R3560 T14052 T14050 nmod β,receptor
R3561 T14053 T14052 punct -,β
R3562 T14054 T14050 nmod type,receptor
R3563 T14055 T14054 nummod I,type
R3564 T14056 T14050 punct ", ",receptor
R3565 T14057 T14058 det a,partner
R3566 T14058 T14050 appos partner,receptor
R3567 T14059 T14058 amod prototypical,partner
R3568 T14060 T14058 compound binding,partner
R3569 T14061 T14058 prep of,partner
R3570 T14062 T14063 compound TGF,βRII
R3571 T14063 T14061 pobj βRII,of
R3572 T14064 T14063 punct -,βRII
R3573 T14065 T14066 punct [,19
R3574 T14066 T14039 parataxis 19,compared
R3575 T14067 T14066 punct ],19
R3576 T14068 T14066 cc and,19
R3577 T14069 T14070 det the,study
R3578 T14070 T14066 conj study,19
R3579 T14071 T14070 amod present,study
R3580 T14072 T14066 punct ),19
R3581 T14073 T14020 punct .,appear
R3582 T14075 T14076 mark While,display
R3583 T14076 T14092 advcl display,demonstrate
R3584 T14077 T14078 compound Tgfbr2,Cre
R3585 T14078 T14082 compound Cre,mutants
R3586 T14079 T14078 punct /,Cre
R3587 T14080 T14078 compound Wnt1,Cre
R3588 T14081 T14078 punct -,Cre
R3589 T14082 T14076 nsubj mutants,display
R3590 T14083 T14084 advmod as,as
R3591 T14084 T14082 cc as,mutants
R3592 T14085 T14084 advmod well,as
R3593 T14086 T14082 conj mice,mutants
R3594 T14087 T14086 amod deficient,mice
R3595 T14088 T14087 prep in,deficient
R3596 T14089 T14090 compound Tgf,β2
R3597 T14090 T14088 pobj β2,in
R3598 T14091 T14090 punct -,β2
R3599 T14093 T14094 det the,A4
R3600 T14094 T14076 dobj A4,display
R3601 T14095 T14094 compound PTA,A4
R3602 T14096 T14094 compound type,A4
R3603 T14097 T14094 punct (,A4
R3604 T14098 T14099 compound truncus,arteriosus
R3605 T14099 T14094 appos arteriosus,A4
R3606 T14100 T14099 prep with,arteriosus
R3607 T14101 T14102 amod interrupted,arch
R3608 T14102 T14100 pobj arch,with
R3609 T14103 T14102 amod aortic,arch
R3610 T14104 T14105 punct [,30
R3611 T14105 T14076 parataxis 30,display
R3612 T14106 T14105 punct ],30
R3613 T14107 T14092 punct ),demonstrate
R3614 T14108 T14092 punct ", ",demonstrate
R3615 T14109 T14110 compound Alk5,Cre
R3616 T14110 T14114 compound Cre,mutants
R3617 T14111 T14110 punct /,Cre
R3618 T14112 T14110 compound Wnt1,Cre
R3619 T14113 T14110 punct -,Cre
R3620 T14114 T14092 nsubj mutants,demonstrate
R3621 T14115 T14114 acl reported,mutants
R3622 T14116 T14115 advmod here,reported
R3623 T14117 T14118 amod earlier,defects
R3624 T14118 T14092 dobj defects,demonstrate
R3625 T14119 T14118 compound patterning,defects
R3626 T14120 T14118 prep of,defects
R3627 T14121 T14122 det the,PAAs
R3628 T14122 T14120 pobj PAAs,of
R3629 T14123 T14118 punct ", ",defects
R3630 T14124 T14125 dep which,is
R3631 T14125 T14118 relcl is,defects
R3632 T14126 T14127 advmod particularly,obvious
R3633 T14127 T14125 acomp obvious,is
R3634 T14128 T14125 prep in,is
R3635 T14129 T14130 det the,pair
R3636 T14130 T14128 pobj pair,in
R3637 T14131 T14130 amod 3rd,pair
R3638 T14132 T14130 prep of,pair
R3639 T14133 T14134 det the,PAAs
R3640 T14134 T14132 pobj PAAs,of
R3641 T14135 T14092 punct .,demonstrate
R3642 T14137 T14138 advmod Moreover,display
R3643 T14139 T14138 punct ", ",display
R3644 T14140 T14141 det the,mutants
R3645 T14141 T14138 nsubj mutants,display
R3646 T14142 T14143 compound Alk5,Cre
R3647 T14143 T14141 compound Cre,mutants
R3648 T14144 T14143 punct /,Cre
R3649 T14145 T14143 compound Wnt1,Cre
R3650 T14146 T14143 punct -,Cre
R3651 T14147 T14148 det an,patterning
R3652 T14148 T14138 dobj patterning,display
R3653 T14149 T14148 amod abnormal,patterning
R3654 T14150 T14148 prep of,patterning
R3655 T14151 T14152 det the,sac
R3656 T14152 T14150 pobj sac,of
R3657 T14153 T14152 amod aortic,sac
R3658 T14154 T14148 cc and,patterning
R3659 T14155 T14156 amod defective,septation
R3660 T14156 T14148 conj septation,patterning
R3661 T14157 T14156 compound AP,septation
R3662 T14158 T14156 acl leading,septation
R3663 T14159 T14158 prep to,leading
R3664 T14160 T14159 pobj PTA,to
R3665 T14161 T14148 punct ", ",patterning
R3666 T14162 T14148 amod reminiscent,patterning
R3667 T14163 T14162 prep of,reminiscent
R3668 T14164 T14165 compound type,A2
R3669 T14165 T14163 pobj A2,of
R3670 T14166 T14165 punct (,A2
R3671 T14167 T14168 punct =,artriosus
R3672 T14168 T14165 acl artriosus,A2
R3673 T14169 T14168 compound truncus,artriosus
R3674 T14170 T14168 prep with,artriosus
R3675 T14171 T14172 det no,segment
R3676 T14172 T14170 pobj segment,with
R3677 T14173 T14172 amod main,segment
R3678 T14174 T14172 amod pulmonary,segment
R3679 T14175 T14172 compound artery,segment
R3680 T14176 T14172 amod present,segment
R3681 T14177 T14178 punct [,30
R3682 T14178 T14148 parataxis 30,patterning
R3683 T14179 T14178 punct ],30
R3684 T14180 T14138 punct ),display
R3685 T14181 T14138 punct .,display
R3686 T14183 T14184 advmod However,demonstrate
R3687 T14185 T14184 punct ", ",demonstrate
R3688 T14186 T14187 poss our,results
R3689 T14187 T14184 nsubj results,demonstrate
R3690 T14188 T14184 advmod also,demonstrate
R3691 T14189 T14190 mark that,leads
R3692 T14190 T14184 ccomp leads,demonstrate
R3693 T14191 T14192 amod significant,hypoplasia
R3694 T14192 T14190 nsubj hypoplasia,leads
R3695 T14193 T14192 prep of,hypoplasia
R3696 T14194 T14195 det the,sac
R3697 T14195 T14193 pobj sac,of
R3698 T14196 T14195 amod aortic,sac
R3699 T14197 T14190 prep to,leads
R3700 T14198 T14199 det a,shortening
R3701 T14199 T14197 pobj shortening,to
R3702 T14200 T14199 amod severe,shortening
R3703 T14201 T14199 prep of,shortening
R3704 T14202 T14203 det the,arch
R3705 T14203 T14201 pobj arch,of
R3706 T14204 T14203 amod ascending,arch
R3707 T14205 T14203 amod truncal,arch
R3708 T14206 T14199 punct ", ",shortening
R3709 T14207 T14208 dep which,masks
R3710 T14208 T14199 relcl masks,shortening
R3711 T14209 T14210 amod possible,defects
R3712 T14210 T14208 dobj defects,masks
R3713 T14211 T14210 prep in,defects
R3714 T14212 T14211 pobj derivatives,in
R3715 T14213 T14212 prep of,derivatives
R3716 T14214 T14215 det the,PAAs
R3717 T14215 T14213 pobj PAAs,of
R3718 T14216 T14215 amod 4th,PAAs
R3719 T14217 T14210 punct ", ",defects
R3720 T14218 T14219 advmod i.e.,interruption
R3721 T14219 T14210 appos interruption,defects
R3722 T14220 T14219 punct ", ",interruption
R3723 T14221 T14219 prep of,interruption
R3724 T14222 T14223 det the,arch
R3725 T14223 T14221 pobj arch,of
R3726 T14224 T14223 amod aortic,arch
R3727 T14225 T14184 punct .,demonstrate
R3728 T14227 T14228 det These,differences
R3729 T14228 T14230 nsubj differences,are
R3730 T14229 T14228 amod observed,differences
R3731 T14231 T14232 advmod likely,due
R3732 T14232 T14230 prep due,are
R3733 T14233 T14232 pcomp to,due
R3734 T14234 T14235 amod substantial,apoptosis
R3735 T14235 T14232 pobj apoptosis,due
R3736 T14236 T14235 prep of,apoptosis
R3737 T14237 T14238 npadvmod Alk5,deficient
R3738 T14238 T14240 amod deficient,cells
R3739 T14239 T14238 punct -,deficient
R3740 T14240 T14236 pobj cells,of
R3741 T14241 T14240 amod post-migratory,cells
R3742 T14242 T14243 amod neural,crest
R3743 T14243 T14240 compound crest,cells
R3744 T14244 T14235 punct ", ",apoptosis
R3745 T14245 T14246 dep which,is
R3746 T14246 T14235 relcl is,apoptosis
R3747 T14247 T14248 advmod clearly,detectable
R3748 T14248 T14246 acomp detectable,is
R3749 T14249 T14246 prep at,is
R3750 T14250 T14249 pobj E10.5,at
R3751 T14251 T14246 punct ", ",is
R3752 T14252 T14253 mark whereas,reported
R3753 T14253 T14246 advcl reported,is
R3754 T14254 T14255 amod similar,death
R3755 T14255 T14253 nsubjpass death,reported
R3756 T14256 T14255 amod intense,death
R3757 T14257 T14255 compound cell,death
R3758 T14258 T14253 aux has,reported
R3759 T14259 T14253 neg not,reported
R3760 T14260 T14253 auxpass been,reported
R3761 T14261 T14253 prep in,reported
R3762 T14262 T14263 compound Tgfbr2,Cre
R3763 T14263 T14267 compound Cre,mutants
R3764 T14264 T14263 punct /,Cre
R3765 T14265 T14263 compound Wnt1,Cre
R3766 T14266 T14263 punct -,Cre
R3767 T14267 T14261 pobj mutants,in
R3768 T14268 T14269 punct [,9
R3769 T14269 T14230 parataxis 9,are
R3770 T14270 T14269 punct ],9
R3771 T14271 T14230 punct .,are
R3772 T14273 T14274 poss Our,results
R3773 T14274 T14276 nsubj results,suggest
R3774 T14275 T14274 amod present,results
R3775 T14277 T14278 mark that,mediates
R3776 T14278 T14276 ccomp mediates,suggest
R3777 T14279 T14280 mark while,mediated
R3778 T14280 T14278 advcl mediated,mediates
R3779 T14281 T14282 compound TGF,β
R3780 T14282 T14284 compound β,signaling
R3781 T14283 T14282 punct -,β
R3782 T14284 T14280 nsubjpass signaling,mediated
R3783 T14285 T14284 prep in,signaling
R3784 T14286 T14287 amod cardiac,NCCs
R3785 T14287 T14285 pobj NCCs,in
R3786 T14288 T14280 auxpass is,mediated
R3787 T14289 T14280 advmod predominantly,mediated
R3788 T14290 T14280 prep via,mediated
R3789 T14291 T14292 det the,complex
R3790 T14292 T14290 pobj complex,via
R3791 T14293 T14294 compound ALK5,βRII
R3792 T14294 T14298 compound βRII,receptor
R3793 T14295 T14294 punct /,βRII
R3794 T14296 T14294 compound TGF,βRII
R3795 T14297 T14294 punct -,βRII
R3796 T14298 T14292 compound receptor,complex
R3797 T14299 T14278 punct ", ",mediates
R3798 T14300 T14278 nsubj ALK5,mediates
R3799 T14301 T14278 advmod also,mediates
R3800 T14302 T14278 dobj signaling,mediates
R3801 T14303 T14302 prep of,signaling
R3802 T14304 T14305 amod other,ligands
R3803 T14305 T14303 pobj ligands,of
R3804 T14306 T14305 amod related,ligands
R3805 T14307 T14305 punct ", ",ligands
R3806 T14308 T14309 dep which,required
R3807 T14309 T14305 relcl required,ligands
R3808 T14310 T14309 auxpass are,required
R3809 T14311 T14312 preconj either,directly
R3810 T14312 T14309 advmod directly,required
R3811 T14361 T14362 advmod Furthermore,induce
R3812 T14313 T14312 cc or,directly
R3813 T14363 T14362 punct ", ",induce
R3814 T14314 T14312 conj indirectly,directly
R3815 T14364 T14365 det a,subset
R3816 T14365 T14362 nsubj subset,induce
R3817 T14315 T14309 prep for,required
R3818 T14366 T14365 prep of,subset
R3819 T14367 T14368 compound TGF,β
R3820 T14368 T14370 npadvmod β,related
R3821 T14316 T14317 amod appropriate,survival
R3822 T14369 T14368 punct -,β
R3823 T14370 T14372 amod related,factors
R3824 T14317 T14315 pobj survival,for
R3825 T14371 T14370 punct -,related
R3826 T14372 T14366 pobj factors,of
R3827 T14373 T14372 nmod growth,factors
R3828 T14318 T14317 compound NCC,survival
R3829 T14374 T14373 cc and,growth
R3830 T14375 T14373 conj differentiation,growth
R3831 T14376 T14372 punct (,factors
R3832 T14319 T14276 punct .,suggest
R3833 T14377 T14372 appos GDFs,factors
R3834 T14378 T14365 punct ),subset
R3835 T14379 T14365 punct ", ",subset
R3836 T14321 T14322 prep In,shown
R3837 T14380 T14381 advmod e.g.,GDF8
R3838 T14381 T14365 appos GDF8,subset
R3839 T14382 T14381 punct ", ",GDF8
R3840 T14383 T14381 punct ", ",GDF8
R3841 T14323 T14321 pobj fact,In
R3842 T14384 T14381 conj GDF9,GDF8
R3843 T14385 T14384 punct ", ",GDF9
R3844 T14386 T14384 conj GDF11,GDF9
R3845 T14387 T14386 cc and,GDF11
R3846 T14388 T14386 conj GDF15,GDF11
R3847 T14389 T14362 aux could,induce
R3848 T14324 T14322 punct ", ",shown
R3849 T14390 T14391 det these,events
R3850 T14391 T14362 dobj events,induce
R3851 T14325 T14322 nsubjpass it,shown
R3852 T14392 T14393 punct [,33
R3853 T14393 T14362 parataxis 33,induce
R3854 T14394 T14393 nummod 17,33
R3855 T14395 T14393 punct ",",33
R3856 T14396 T14393 nummod 18,33
R3857 T14326 T14322 aux has,shown
R3858 T14397 T14393 punct ",",33
R3859 T14398 T14393 nummod 32,33
R3860 T14399 T14393 punct ",",33
R3861 T14327 T14322 auxpass been,shown
R3862 T14400 T14393 punct ],33
R3863 T14401 T14362 punct .,induce
R3864 T14328 T14329 mark that,form
R3865 T14329 T14322 ccomp form,shown
R3866 T14403 T14404 mark Although,display
R3867 T14330 T14329 punct ", ",form
R3868 T14404 T14429 advcl display,exclude
R3869 T14405 T14406 amod relevant,8
R3870 T14331 T14329 prep besides,form
R3871 T14406 T14408 nsubjpass 8,expressed
R3872 T14407 T14406 nmod Gdfs,8
R3873 T14408 T14404 ccomp expressed,display
R3874 T14332 T14333 compound TGF,βRII
R3875 T14409 T14406 punct ", ",8
R3876 T14410 T14411 nummod 9,11
R3877 T14333 T14331 pobj βRII,besides
R3878 T14411 T14406 conj 11,8
R3879 T14412 T14411 cc and,11
R3880 T14413 T14411 conj 15,11
R3881 T14334 T14333 punct -,βRII
R3882 T14414 T14408 auxpass are,expressed
R3883 T14415 T14408 neg not,expressed
R3884 T14335 T14329 punct ", ",form
R3885 T14416 T14408 prep in,expressed
R3886 T14417 T14418 det the,heart
R3887 T14418 T14416 pobj heart,in
R3888 T14336 T14329 nsubj ALK5,form
R3889 T14419 T14418 amod developing,heart
R3890 T14420 T14404 punct ", ",display
R3891 T14421 T14404 cc nor,display
R3892 T14337 T14329 aux can,form
R3893 T14422 T14404 aux do,display
R3894 T14423 T14424 det the,mice
R3895 T14424 T14404 nsubj mice,display
R3896 T14425 T14424 amod deficient,mice
R3897 T14426 T14425 prep in,deficient
R3898 T14338 T14329 advmod also,form
R3899 T14427 T14428 det these,Gdfs
R3900 T14428 T14426 pobj Gdfs,in
R3901 T14339 T14340 det a,complex
R3902 T14430 T14431 amod developmental,defects
R3903 T14431 T14404 dobj defects,display
R3904 T14340 T14329 dobj complex,form
R3905 T14432 T14431 amod cardiac,defects
R3906 T14341 T14340 prep with,complex
R3907 T14433 T14429 punct ", ",exclude
R3908 T14434 T14429 nsubj we,exclude
R3909 T14435 T14429 aux can,exclude
R3910 T14436 T14429 neg not,exclude
R3911 T14342 T14343 det the,receptor
R3912 T14437 T14438 det the,possibility
R3913 T14438 T14429 dobj possibility,exclude
R3914 T14439 T14440 mark that,contribute
R3915 T14343 T14341 pobj receptor,with
R3916 T14440 T14438 acl contribute,possibility
R3917 T14441 T14442 amod circulating,GDFs
R3918 T14344 T14343 compound Activin,receptor
R3919 T14442 T14440 nsubj GDFs,contribute
R3920 T14443 T14442 punct ", ",GDFs
R3921 T14444 T14445 advmod perhaps,in
R3922 T14345 T14346 compound type,IIB
R3923 T14445 T14442 prep in,GDFs
R3924 T14446 T14445 pobj concert,in
R3925 T14447 T14446 prep with,concert
R3926 T14346 T14343 compound IIB,receptor
R3927 T14448 T14449 compound TGF,βs
R3928 T14449 T14447 pobj βs,with
R3929 T14450 T14449 punct -,βs
R3930 T14347 T14348 aux to,activate
R3931 T14451 T14440 aux may,contribute
R3932 T14452 T14440 prep to,contribute
R3933 T14453 T14454 compound NCC,survival
R3934 T14348 T14329 advcl activate,form
R3935 T14454 T14452 pobj survival,to
R3936 T14455 T14440 prep during,contribute
R3937 T14456 T14457 amod cardiac,morphogenesis
R3938 T14349 T14350 amod downstream,Smads
R3939 T14457 T14455 pobj morphogenesis,during
R3940 T14458 T14456 cc and,cardiac
R3941 T14459 T14456 conj pharyngeal,cardiac
R3942 T14350 T14348 dobj Smads,activate
R3943 T14460 T14429 punct .,exclude
R3944 T14351 T14350 nummod 2,Smads
R3945 T14462 T14463 nsubj We,studied
R3946 T14352 T14350 punct /,Smads
R3947 T14464 T14463 advmod specifically,studied
R3948 T14465 T14463 dobj apoptosis,studied
R3949 T14353 T14350 nummod 3,Smads
R3950 T14354 T14355 punct [,31
R3951 T14466 T14465 prep at,apoptosis
R3952 T14467 T14468 det the,level
R3953 T14355 T14329 parataxis 31,form
R3954 T14468 T14466 pobj level,at
R3955 T14469 T14468 prep of,level
R3956 T14470 T14471 det the,sac
R3957 T14356 T14355 nummod 18,31
R3958 T14471 T14469 pobj sac,of
R3959 T14472 T14471 amod aortic,sac
R3960 T14473 T14471 punct ", ",sac
R3961 T14357 T14355 punct ",",31
R3962 T14474 T14475 advmod where,forms
R3963 T14358 T14355 punct ],31
R3964 T14475 T14471 relcl forms,sac
R3965 T14476 T14477 det the,septum
R3966 T14477 T14475 nsubj septum,forms
R3967 T14478 T14477 compound AP,septum
R3968 T14359 T14322 punct .,shown
R3969 T14479 T14477 punct -,septum
R3970 T14480 T14475 prep between,forms
R3971 T14481 T14482 det the,origins
R3972 T14572 T14564 prep between,forming
R3973 T14482 T14480 pobj origins,between
R3974 T14483 T14482 prep of,origins
R3975 T14484 T14485 amod 4th,PAAs
R3976 T14573 T14572 pobj E10.5,between
R3977 T14485 T14483 pobj PAAs,of
R3978 T14486 T14484 cc and,4th
R3979 T14487 T14484 conj 6th,4th
R3980 T14574 T14573 cc and,E10.5
R3981 T14488 T14463 punct .,studied
R3982 T14490 T14491 advmod Already,see
R3983 T14575 T14573 conj E11.5,E10.5
R3984 T14491 T14497 ccomp see,precedes
R3985 T14492 T14491 prep at,see
R3986 T14576 T14542 punct .,detect
R3987 T14493 T14492 pobj E10.5,at
R3988 T14494 T14491 punct ", ",see
R3989 T14495 T14491 nsubj we,see
R3990 T14578 T14579 det These,findings
R3991 T14496 T14491 aux could,see
R3992 T14498 T14499 amod intense,apoptosis
R3993 T14579 T14580 nsubj findings,suggest
R3994 T14499 T14491 dobj apoptosis,see
R3995 T14500 T14499 prep among,apoptosis
R3996 T14501 T14502 det the,NCCs
R3997 T14581 T14582 mark that,affected
R3998 T14502 T14500 pobj NCCs,among
R3999 T14503 T14502 amod postmigratory,NCCs
R4000 T14504 T14491 prep in,see
R4001 T14505 T14506 det the,mesenchyme
R4002 T14506 T14504 pobj mesenchyme,in
R4003 T14507 T14506 acl surrounding,mesenchyme
R4004 T14582 T14580 ccomp affected,suggest
R4005 T14508 T14509 det the,sac
R4006 T14509 T14507 dobj sac,surrounding
R4007 T14510 T14509 amod aortic,sac
R4008 T14511 T14491 prep at,see
R4009 T14583 T14584 det the,pool
R4010 T14512 T14513 det the,site
R4011 T14513 T14511 pobj site,at
R4012 T14514 T14515 advmod where,forms
R4013 T14584 T14582 nsubjpass pool,affected
R4014 T14515 T14513 relcl forms,site
R4015 T14516 T14517 det the,septum
R4016 T14517 T14515 nsubj septum,forms
R4017 T14585 T14584 prep of,pool
R4018 T14518 T14517 amod prospective,septum
R4019 T14519 T14517 compound AP,septum
R4020 T14520 T14497 punct ", ",precedes
R4021 T14586 T14585 pobj cells,of
R4022 T14521 T14497 advmod i.e.,precedes
R4023 T14522 T14497 punct ", ",precedes
R4024 T14523 T14524 det this,death
R4025 T14587 T14584 acl forming,pool
R4026 T14524 T14497 nsubj death,precedes
R4027 T14525 T14524 compound cell,death
R4028 T14526 T14527 det the,defect
R4029 T14588 T14589 det the,septum
R4030 T14527 T14497 dobj defect,precedes
R4031 T14528 T14527 nmod AP,defect
R4032 T14529 T14527 amod septal,defect
R4033 T14589 T14587 dobj septum,forming
R4034 T14530 T14527 acl seen,defect
R4035 T14531 T14530 prep in,seen
R4036 T14590 T14589 compound AP,septum
R4037 T14532 T14531 pobj mutants,in
R4038 T14533 T14497 punct .,precedes
R4039 T14591 T14582 auxpass is,affected
R4040 T14535 T14536 mark Although,appeared
R4041 T14536 T14542 advcl appeared,detect
R4042 T14592 T14582 advmod severely,affected
R4043 T14537 T14538 det some,cells
R4044 T14538 T14536 nsubj cells,appeared
R4045 T14539 T14540 npadvmod NC,derived
R4046 T14593 T14582 agent by,affected
R4047 T14540 T14538 amod derived,cells
R4048 T14541 T14540 punct -,derived
R4049 T14594 T14595 det the,death
R4050 T14543 T14544 aux to,differentiating
R4051 T14544 T14536 xcomp differentiating,appeared
R4052 T14545 T14544 aux be,differentiating
R4053 T14546 T14544 prep to,differentiating
R4054 T14547 T14548 amod smooth,cells
R4055 T14595 T14593 pobj death,by
R4056 T14548 T14546 pobj cells,to
R4057 T14549 T14548 compound muscle,cells
R4058 T14550 T14544 prep in,differentiating
R4059 T14596 T14595 compound cell,death
R4060 T14551 T14552 det the,OFT
R4061 T14552 T14550 pobj OFT,in
R4062 T14553 T14554 punct (,Fig.
R4063 T14597 T14580 punct .,suggest
R4064 T14554 T14544 parataxis Fig.,differentiating
R4065 T14555 T14554 nummod 6,Fig.
R4066 T14556 T14554 punct ),Fig.
R4067 T14599 T14600 advmod Moreover,is
R4068 T14557 T14542 punct ", ",detect
R4069 T14558 T14542 nsubj we,detect
R4070 T14559 T14542 aux could,detect
R4071 T14560 T14542 neg never,detect
R4072 T14601 T14600 punct ", ",is
R4073 T14561 T14562 det the,septum
R4074 T14562 T14564 nsubj septum,forming
R4075 T14563 T14562 compound AP,septum
R4076 T14564 T14542 ccomp forming,detect
R4077 T14602 T14600 nsubj it,is
R4078 T14565 T14564 prep in,forming
R4079 T14566 T14567 compound Alk5,Cre
R4080 T14567 T14571 compound Cre,mutants
R4081 T14603 T14600 acomp likely,is
R4082 T14568 T14567 punct /,Cre
R4083 T14569 T14567 compound Wnt1,Cre
R4084 T14570 T14567 punct -,Cre
R4085 T14604 T14605 mark that,die
R4086 T14571 T14565 pobj mutants,in
R4087 T14605 T14600 ccomp die,is
R4088 T14606 T14607 det these,cells
R4089 T14607 T14605 nsubj cells,die
R4090 T14608 T14607 acl forming,cells
R4091 T14678 T14679 punct [,9
R4092 T14609 T14610 det the,septum
R4093 T14679 T14652 parataxis 9,suggested
R4094 T14680 T14679 punct ],9
R4095 T14610 T14608 dobj septum,forming
R4096 T14681 T14652 punct ", ",suggested
R4097 T14682 T14683 mark although,disputed
R4098 T14611 T14610 compound AP,septum
R4099 T14683 T14652 advcl disputed,suggested
R4100 T14684 T14685 det this,result
R4101 T14685 T14683 nsubjpass result,disputed
R4102 T14612 T14610 punct -,septum
R4103 T14686 T14683 auxpass was,disputed
R4104 T14687 T14683 advmod later,disputed
R4105 T14688 T14683 agent by,disputed
R4106 T14689 T14690 det another,study
R4107 T14690 T14688 pobj study,by
R4108 T14613 T14605 dep the,die
R4109 T14691 T14692 punct [,8
R4110 T14692 T14683 parataxis 8,disputed
R4111 T14693 T14692 punct ],8
R4112 T14614 T14615 mark before,differentiate
R4113 T14694 T14652 punct .,suggested
R4114 T14615 T14605 advcl differentiate,die
R4115 T14696 T14697 poss Our,staining
R4116 T14697 T14699 nsubj staining,demonstrated
R4117 T14698 T14697 amod immunohistochemical,staining
R4118 T14616 T14615 nsubj majority,differentiate
R4119 T14700 T14697 prep of,staining
R4120 T14617 T14616 prep of,majority
R4121 T14701 T14700 pobj αSMA,of
R4122 T14702 T14697 prep in,staining
R4123 T14703 T14704 det the,OFT
R4124 T14618 T14617 pobj them,of
R4125 T14704 T14702 pobj OFT,in
R4126 T14619 T14615 aux can,differentiate
R4127 T14705 T14699 advmod unequivocally,demonstrated
R4128 T14706 T14707 mark that,required
R4129 T14707 T14699 ccomp required,demonstrated
R4130 T14620 T14615 prep to,differentiate
R4131 T14708 T14707 nsubjpass signaling,required
R4132 T14709 T14708 prep via,signaling
R4133 T14710 T14709 pobj ALK5,via
R4134 T14621 T14622 amod smooth,cells
R4135 T14711 T14707 auxpass is,required
R4136 T14712 T14707 neg not,required
R4137 T14622 T14620 pobj cells,to
R4138 T14713 T14707 prep for,required
R4139 T14714 T14715 amod smooth,muscle
R4140 T14715 T14716 compound muscle,differentiation
R4141 T14623 T14622 compound muscle,cells
R4142 T14716 T14713 pobj differentiation,for
R4143 T14717 T14718 advmod in,vivo
R4144 T14624 T14600 punct .,is
R4145 T14718 T14707 advmod vivo,required
R4146 T14719 T14699 punct .,demonstrated
R4147 T14626 T14627 amod Several,studies
R4148 T14721 T14722 advmod Moreover,suggested
R4149 T14723 T14722 punct ", ",suggested
R4150 T14627 T14630 nsubj studies,suggested
R4151 T14724 T14722 nsubjpass it,suggested
R4152 T14725 T14722 aux has,suggested
R4153 T14726 T14722 auxpass been,suggested
R4154 T14628 T14629 advmod in,vitro
R4155 T14727 T14728 mark that,leads
R4156 T14728 T14722 ccomp leads,suggested
R4157 T14729 T14728 nsubj deletion,leads
R4158 T14730 T14729 prep of,deletion
R4159 T14731 T14730 pobj Tgfbr2,of
R4160 T14732 T14729 prep in,deletion
R4161 T14629 T14627 amod vitro,studies
R4162 T14733 T14732 pobj NCCs,in
R4163 T14734 T14728 prep to,leads
R4164 T14735 T14736 amod other,features
R4165 T14631 T14630 aux have,suggested
R4166 T14736 T14734 pobj features,to
R4167 T14737 T14736 amod phenotypic,features
R4168 T14738 T14736 amod reminiscent,features
R4169 T14739 T14738 prep of,reminiscent
R4170 T14632 T14633 det an,role
R4171 T14740 T14739 pobj those,of
R4172 T14741 T14740 acl seen,those
R4173 T14742 T14741 prep in,seen
R4174 T14633 T14630 dobj role,suggested
R4175 T14743 T14744 det the,syndrome
R4176 T14634 T14633 amod indispensable,role
R4177 T14744 T14742 pobj syndrome,in
R4178 T14635 T14633 prep for,role
R4179 T14745 T14746 amod velocardiofacial,DiGeorge
R4180 T14746 T14744 compound DiGeorge,syndrome
R4181 T14747 T14746 punct /,DiGeorge
R4182 T14636 T14637 compound TGF,β
R4183 T14748 T14744 punct (,syndrome
R4184 T14749 T14750 compound VCF,DGS
R4185 T14637 T14635 pobj β,for
R4186 T14750 T14744 appos DGS,syndrome
R4187 T14751 T14750 punct /,DGS
R4188 T14752 T14741 punct ),seen
R4189 T14638 T14637 punct -,β
R4190 T14753 T14754 punct [,9
R4191 T14754 T14741 parataxis 9,seen
R4192 T14639 T14637 punct -,β
R4193 T14755 T14754 punct ],9
R4194 T14756 T14736 acl caused,features
R4195 T14640 T14637 amod signaling,β
R4196 T14757 T14756 agent by,caused
R4197 T14758 T14759 det a,deletion
R4198 T14759 T14757 pobj deletion,by
R4199 T14641 T14633 prep in,role
R4200 T14760 T14759 prep of,deletion
R4201 T14761 T14762 det the,region
R4202 T14642 T14641 pobj differentiation,in
R4203 T14762 T14760 pobj region,of
R4204 T14763 T14764 advmod so,called
R4205 T14643 T14642 prep of,differentiation
R4206 T14764 T14762 amod called,region
R4207 T14765 T14762 nmod DiGeorge,region
R4208 T14766 T14762 amod critical,region
R4209 T14767 T14762 punct (,region
R4210 T14768 T14762 appos DGCR,region
R4211 T14769 T14759 punct ),deletion
R4212 T14644 T14643 pobj NCCs,of
R4213 T14770 T14759 prep on,deletion
R4214 T14771 T14772 compound chromosome,22q11
R4215 T14645 T14644 prep into,NCCs
R4216 T14772 T14770 pobj 22q11,on
R4217 T14773 T14774 punct [,35
R4218 T14774 T14722 parataxis 35,suggested
R4219 T14646 T14647 amod smooth,muscle
R4220 T14775 T14774 nummod 34,35
R4221 T14776 T14774 punct ",",35
R4222 T14647 T14648 compound muscle,cells
R4223 T14777 T14774 punct ],35
R4224 T14778 T14722 punct .,suggested
R4225 T14648 T14645 pobj cells,into
R4226 T14780 T14781 poss Our,results
R4227 T14781 T14783 nsubj results,suggest
R4228 T14649 T14630 punct .,suggested
R4229 T14782 T14781 amod present,results
R4230 T14651 T14652 advmod Moreover,suggested
R4231 T14653 T14652 punct ", ",suggested
R4232 T14784 T14785 mark that,shows
R4233 T14654 T14655 det a,study
R4234 T14785 T14783 ccomp shows,suggest
R4235 T14786 T14787 mark although,resemble
R4236 T14655 T14652 nsubj study,suggested
R4237 T14787 T14785 advcl resemble,shows
R4238 T14788 T14787 nsubj many,resemble
R4239 T14789 T14788 prep of,many
R4240 T14656 T14655 amod recent,study
R4241 T14790 T14791 det the,phenotypes
R4242 T14791 T14789 pobj phenotypes,of
R4243 T14792 T14791 amod observed,phenotypes
R4244 T14657 T14658 advmod in,vivo
R4245 T14793 T14788 acl seen,many
R4246 T14794 T14793 prep in,seen
R4247 T14658 T14655 amod vivo,study
R4248 T14795 T14796 compound Alk5,Cre
R4249 T14796 T14800 compound Cre,mutants
R4250 T14797 T14796 punct /,Cre
R4251 T14659 T14660 mark that,display
R4252 T14798 T14796 compound Wnt1,Cre
R4253 T14799 T14796 punct -,Cre
R4254 T14800 T14794 pobj mutants,in
R4255 T14660 T14652 ccomp display,suggested
R4256 T14801 T14787 advmod superficially,resemble
R4257 T14802 T14787 dobj those,resemble
R4258 T14661 T14660 nsubj mice,display
R4259 T14803 T14802 acl seen,those
R4260 T14804 T14803 prep in,seen
R4261 T14805 T14806 compound VCF,DGS
R4262 T14806 T14804 pobj DGS,in
R4263 T14807 T14806 punct /,DGS
R4264 T14808 T14785 punct ", ",shows
R4265 T14662 T14661 acl lacking,mice
R4266 T14809 T14810 det a,examination
R4267 T14810 T14785 nsubj examination,shows
R4268 T14663 T14662 dobj Tgfbr2,lacking
R4269 T14811 T14810 amod detailed,examination
R4270 T14812 T14813 mark that,lead
R4271 T14664 T14663 prep in,Tgfbr2
R4272 T14813 T14785 ccomp lead,shows
R4273 T14814 T14815 det the,abrogation
R4274 T14815 T14813 nsubj abrogation,lead
R4275 T14665 T14664 pobj CNCCs,in
R4276 T14816 T14817 npadvmod NC,specific
R4277 T14817 T14815 amod specific,abrogation
R4278 T14666 T14667 amod defective,differentiation
R4279 T14818 T14817 punct -,specific
R4280 T14819 T14815 prep of,abrogation
R4281 T14820 T14819 pobj Alk5,of
R4282 T14667 T14660 dobj differentiation,display
R4283 T14821 T14813 aux does,lead
R4284 T14822 T14813 neg not,lead
R4285 T14823 T14813 prep to,lead
R4286 T14668 T14667 compound NCC,differentiation
R4287 T14824 T14825 compound VCF,DGS
R4288 T14825 T14827 npadvmod DGS,like
R4289 T14669 T14660 prep into,display
R4290 T14826 T14825 punct /,DGS
R4291 T14827 T14829 amod like,phenotypes
R4292 T14670 T14671 npadvmod αSMA,positive
R4293 T14828 T14827 punct -,like
R4294 T14671 T14673 amod positive,cells
R4295 T14829 T14823 pobj phenotypes,to
R4296 T14672 T14671 punct -,positive
R4297 T14830 T14783 punct .,suggest
R4298 T14673 T14669 pobj cells,into
R4299 T14832 T14833 advmod Firstly,seem
R4300 T14674 T14660 prep in,display
R4301 T14834 T14833 punct ", ",seem
R4302 T14835 T14836 mark while,fails
R4303 T14675 T14676 det the,septum
R4304 T14836 T14833 advcl fails,seem
R4305 T14837 T14838 det the,migration
R4306 T14838 T14836 nsubj migration,fails
R4307 T14676 T14674 pobj septum,in
R4308 T14839 T14840 amod pharyngeal,organ
R4309 T14840 T14838 compound organ,migration
R4310 T14841 T14836 prep in,fails
R4311 T14842 T14843 compound Alk5,Cre
R4312 T14843 T14847 compound Cre,mutants
R4313 T14844 T14843 punct /,Cre
R4314 T14677 T14676 compound AP,septum
R4315 T14845 T14843 compound Wnt1,Cre
R4316 T14846 T14843 punct -,Cre
R4317 T14847 T14841 pobj mutants,in
R4318 T14889 T14887 acl seen,death
R4319 T14848 T14836 punct ", ",fails
R4320 T14849 T14850 advmod perhaps,as
R4321 T14850 T14836 prep as,fails
R4322 T14890 T14889 prep in,seen
R4323 T14851 T14852 det a,result
R4324 T14852 T14850 pobj result,as
R4325 T14853 T14852 prep of,result
R4326 T14891 T14892 compound Alk5,mutants
R4327 T14854 T14855 amod increased,death
R4328 T14855 T14853 pobj death,of
R4329 T14856 T14857 amod mesenchymal,cell
R4330 T14892 T14890 pobj mutants,in
R4331 T14857 T14855 compound cell,death
R4332 T14858 T14855 prep in,death
R4333 T14859 T14860 det the,region
R4334 T14893 T14894 det a,population
R4335 T14860 T14858 pobj region,in
R4336 T14861 T14860 amod pharyngeal,region
R4337 T14894 T14884 dobj population,affects
R4338 T14862 T14833 punct ", ",seem
R4339 T14863 T14864 preconj both,thymus
R4340 T14864 T14833 nsubj thymus,seem
R4341 T14895 T14896 advmod predominantly,postmigratory
R4342 T14865 T14864 det the,thymus
R4343 T14866 T14864 punct ", ",thymus
R4344 T14867 T14864 conj thyroid,thymus
R4345 T14896 T14894 amod postmigratory,population
R4346 T14868 T14867 cc and,thyroid
R4347 T14869 T14867 conj parathyroid,thyroid
R4348 T14897 T14894 prep of,population
R4349 T14870 T14871 aux to,develop
R4350 T14871 T14833 xcomp develop,seem
R4351 T14872 T14873 advmod relatively,normally
R4352 T14898 T14897 pobj NCCs,of
R4353 T14873 T14871 advmod normally,develop
R4354 T14874 T14871 prep on,develop
R4355 T14875 T14876 det the,level
R4356 T14899 T14884 punct ", ",affects
R4357 T14876 T14874 pobj level,on
R4358 T14877 T14876 amod histological,level
R4359 T14878 T14871 prep in,develop
R4360 T14900 T14901 mark while,control
R4361 T14879 T14880 det these,mutants
R4362 T14880 T14878 pobj mutants,in
R4363 T14881 T14833 punct .,seem
R4364 T14883 T14884 advmod Secondly,affects
R4365 T14901 T14884 advcl control,affects
R4366 T14885 T14884 punct ", ",affects
R4367 T14886 T14887 det the,death
R4368 T14902 T14901 nsubj genes,control
R4369 T14887 T14884 nsubj death,affects
R4370 T14888 T14887 compound NCC,death
R4371 T14903 T14902 acl located,genes
R4372 T14904 T14903 prep in,located
R4373 T14905 T14906 det the,DGCR
R4374 T14995 T14993 nsubj migration,resulted
R4375 T14996 T14995 amod defective,migration
R4376 T14906 T14904 pobj DGCR,in
R4377 T14997 T14995 prep of,migration
R4378 T14998 T14997 pobj cells,of
R4379 T14999 T14995 prep from,migration
R4380 T14907 T14906 punct ", ",DGCR
R4381 T14908 T14909 advmod i.e.,Tbx1
R4382 T15000 T15001 det the,field
R4383 T15001 T14999 pobj field,from
R4384 T14909 T14906 appos Tbx1,DGCR
R4385 T15002 T15001 amod secondary,field
R4386 T15003 T15001 compound heart,field
R4387 T14910 T14909 punct ", ",Tbx1
R4388 T15004 T14995 prep to,migration
R4389 T15005 T15006 det the,OFT
R4390 T15006 T15004 pobj OFT,to
R4391 T14911 T14909 cc and,Tbx1
R4392 T15007 T14993 prep in,resulted
R4393 T15008 T15007 pobj turn,in
R4394 T14912 T14909 conj CrkL,Tbx1
R4395 T15009 T14993 prep in,resulted
R4396 T15010 T15009 pobj shortening,in
R4397 T14913 T14901 punct ", ",control
R4398 T15011 T15010 cc and,shortening
R4399 T15012 T15013 amod inappropriate,rotation
R4400 T14914 T14915 compound NCC,survival
R4401 T14915 T14901 dobj survival,control
R4402 T14916 T14901 advmod earlier,control
R4403 T15013 T15010 conj rotation,shortening
R4404 T15014 T15010 prep of,shortening
R4405 T14917 T14901 prep at,control
R4406 T15015 T15016 det the,OFT
R4407 T15016 T15014 pobj OFT,of
R4408 T14918 T14917 pobj E8.5,at
R4409 T15017 T14993 punct ", ",resulted
R4410 T15018 T14993 advcl leading,resulted
R4411 T15019 T15018 prep to,leading
R4412 T14919 T14920 punct -,E10
R4413 T15020 T15019 pobj mal-alignment,to
R4414 T15021 T15020 prep of,mal-alignment
R4415 T15022 T15023 det the,pole
R4416 T15023 T15021 pobj pole,of
R4417 T15024 T15023 amod arterial,pole
R4418 T15025 T15020 prep with,mal-alignment
R4419 T14920 T14918 prep E10,E8.5
R4420 T15026 T15027 det the,ventricles
R4421 T15027 T15025 pobj ventricles,with
R4422 T15028 T15029 punct [,41
R4423 T14921 T14901 prep by,control
R4424 T15029 T14993 parataxis 41,resulted
R4425 T15030 T15029 punct ],41
R4426 T15031 T14990 punct .,suggested
R4427 T14922 T14921 pcomp regulating,by
R4428 T15033 T15034 mark While,shared
R4429 T15034 T15046 advcl shared,suggest
R4430 T14923 T14922 dobj proliferation,regulating
R4431 T15035 T15036 det the,phenotype
R4432 T15036 T15034 nsubj phenotype,shared
R4433 T14924 T14923 prep of,proliferation
R4434 T15037 T15036 amod detected,phenotype
R4435 T15038 T15036 compound OFT,phenotype
R4436 T15039 T15036 prep in,phenotype
R4437 T15040 T15041 compound Alk5,Cre
R4438 T14925 T14926 det the,field
R4439 T15041 T15045 compound Cre,mutants
R4440 T15042 T15041 punct /,Cre
R4441 T15043 T15041 compound Wnt1,Cre
R4442 T14926 T14924 pobj field,of
R4443 T15044 T15041 punct -,Cre
R4444 T15045 T15039 pobj mutants,in
R4445 T14927 T14926 amod secondary,field
R4446 T15047 T15048 amod many,similarities
R4447 T15048 T15034 dobj similarities,shared
R4448 T14928 T14926 compound heart,field
R4449 T15049 T15034 prep with,shared
R4450 T15050 T15049 pobj that,with
R4451 T15051 T15050 acl seen,that
R4452 T14929 T14926 punct (,field
R4453 T15052 T15051 prep in,seen
R4454 T15053 T15054 det the,models
R4455 T15054 T15052 pobj models,in
R4456 T14930 T14926 appos SHF,field
R4457 T15055 T15054 compound chick,models
R4458 T14931 T14923 punct ),proliferation
R4459 T15056 T15054 compound NC,models
R4460 T15057 T15054 compound ablation,models
R4461 T15058 T15054 punct ", ",models
R4462 T15059 T15060 advmod e.g.,PTA
R4463 T14932 T14923 punct ", ",proliferation
R4464 T15060 T15054 appos PTA,models
R4465 T15061 T15060 punct ", ",PTA
R4466 T15062 T15060 cc and,PTA
R4467 T15063 T15064 det the,sac
R4468 T15064 T15060 conj sac,PTA
R4469 T14933 T14923 cc and,proliferation
R4470 T15065 T15064 amod hypoplastic,sac
R4471 T15066 T15064 amod aortic,sac
R4472 T15067 T15046 punct ", ",suggest
R4473 T14934 T14935 compound endoderm,expansion
R4474 T15068 T15069 poss our,results
R4475 T15069 T15046 nsubj results,suggest
R4476 T15070 T15069 amod current,results
R4477 T14935 T14923 conj expansion,proliferation
R4478 T15071 T15072 mark that,affected
R4479 T15072 T15046 ccomp affected,suggest
R4480 T15073 T15074 det the,field
R4481 T14936 T14935 punct ", ",expansion
R4482 T15074 T15072 nsubjpass field,affected
R4483 T15075 T15074 amod secondary,field
R4484 T14937 T14938 dep which,provides
R4485 T15076 T15074 compound heart,field
R4486 T15077 T15072 auxpass is,affected
R4487 T15078 T15072 neg not,affected
R4488 T15079 T15072 advmod severely,affected
R4489 T14938 T14935 relcl provides,expansion
R4490 T15080 T15072 prep in,affected
R4491 T15081 T15082 compound Alk5,mutants
R4492 T14939 T14938 prep in,provides
R4493 T14940 T14939 pobj turn,in
R4494 T15082 T15080 pobj mutants,in
R4495 T15083 T15084 punct (,shown
R4496 T14941 T14942 compound survival,signal
R4497 T15084 T15072 parataxis shown,affected
R4498 T15085 T15084 nsubj data,shown
R4499 T15086 T15084 neg not,shown
R4500 T14942 T14938 dobj signal,provides
R4501 T15087 T15084 punct ),shown
R4502 T15088 T15046 punct .,suggest
R4503 T14943 T14942 prep for,signal
R4504 T15090 T15091 mark Since,detect
R4505 T15091 T15095 advcl detect,appears
R4506 T14944 T14943 pobj NCCs,for
R4507 T15092 T15091 nsubj we,detect
R4508 T15093 T15091 aux could,detect
R4509 T15094 T15091 neg not,detect
R4510 T14945 T14938 advcl allowing,provides
R4511 T15096 T15097 amod appropriate,rotation
R4512 T15097 T15091 dobj rotation,detect
R4513 T14946 T14945 dobj them,allowing
R4514 T15098 T15097 prep of,rotation
R4515 T15099 T15100 det the,OFT
R4516 T14947 T14948 aux to,populate
R4517 T15100 T15098 pobj OFT,of
R4518 T14948 T14945 xcomp populate,allowing
R4519 T15101 T15091 prep in,detect
R4520 T15102 T15103 amod neural,crest
R4521 T14949 T14950 det the,region
R4522 T15103 T15104 npadvmod crest,specific
R4523 T15104 T15106 amod specific,mutants
R4524 T15105 T15104 punct -,specific
R4525 T14950 T14948 dobj region,populate
R4526 T15106 T15101 pobj mutants,in
R4527 T15107 T15106 prep of,mutants
R4528 T15108 T15107 pobj Alk5,of
R4529 T14951 T14950 amod pharyngeal,region
R4530 T15109 T15108 cc or,Alk5
R4531 T15110 T15108 conj Alk2,Alk5
R4532 T14952 T14953 punct [,36
R4533 T15111 T15095 punct ", ",appears
R4534 T15112 T15095 nsubj it,appears
R4535 T15113 T15114 mark that,required
R4536 T14953 T14938 parataxis 36,provides
R4537 T15114 T15095 ccomp required,appears
R4538 T15115 T15114 nsubjpass cells,required
R4539 T14954 T14955 punct -,39
R4540 T15116 T15115 acl derived,cells
R4541 T15117 T15116 prep from,derived
R4542 T15118 T15119 det the,NC
R4543 T14955 T14953 prep 39,36
R4544 T15119 T15117 pobj NC,from
R4545 T15120 T15115 punct ", ",cells
R4546 T15121 T15122 advmod as,as
R4547 T14956 T14953 punct ],36
R4548 T15122 T15115 cc as,cells
R4549 T15123 T15122 advmod well,as
R4550 T15124 T15115 conj those,cells
R4551 T14957 T14884 punct .,affects
R4552 T15125 T15124 prep from,those
R4553 T15126 T15127 det the,SHF
R4554 T14959 T14960 compound NCC,ablation
R4555 T15127 T15125 pobj SHF,from
R4556 T15128 T15114 punct ", ",required
R4557 T15129 T15114 auxpass are,required
R4558 T15130 T15114 advmod mutually,required
R4559 T14960 T14961 nsubjpass ablation,shown
R4560 T15131 T15114 prep for,required
R4561 T15132 T15133 amod proper,rotation
R4562 T15133 T15131 pobj rotation,for
R4563 T14962 T14960 prep in,ablation
R4564 T15134 T15133 compound OFT,rotation
R4565 T15135 T15114 prep in,required
R4566 T15136 T15135 pobj mice,in
R4567 T14963 T14964 det the,chick
R4568 T15137 T15095 punct .,appears
R4569 T15139 T15140 advmod However,appears
R4570 T14964 T14962 pobj chick,in
R4571 T15141 T15140 punct ", ",appears
R4572 T15142 T15140 nsubj it,appears
R4573 T15143 T15144 mark that,contribute
R4574 T15144 T15140 ccomp contribute,appears
R4575 T15145 T15146 det these,receptors
R4576 T14965 T14961 aux has,shown
R4577 T15146 T15144 nsubj receptors,contribute
R4578 T15147 T15146 nummod two,receptors
R4579 T15148 T15149 nmod TGF,BMP
R4580 T14966 T14961 auxpass been,shown
R4581 T15149 T15146 nmod BMP,receptors
R4582 T15150 T15149 punct -,BMP
R4583 T15151 T15149 nmod β,BMP
R4584 T14967 T14968 aux to,lead
R4585 T15152 T15149 punct /,BMP
R4586 T15153 T15146 nmod type,receptors
R4587 T15154 T15153 nummod I,type
R4588 T14968 T14961 xcomp lead,shown
R4589 T15155 T15144 prep to,contribute
R4590 T15156 T15157 compound OFT,rotation
R4591 T15157 T15155 pobj rotation,to
R4592 T14969 T14968 prep to,lead
R4593 T15158 T15144 prep through,contribute
R4594 T15159 T15160 amod different,mechanisms
R4595 T14970 T14969 pobj PTA,to
R4596 T15160 T15158 pobj mechanisms,through
R4597 T15161 T15140 punct .,appears
R4598 T15163 T15164 prep In,is
R4599 T14971 T14969 cc and,to
R4600 T15165 T15166 compound Alk5,mutants
R4601 T14972 T14969 conj to,to
R4602 T15166 T15163 pobj mutants,In
R4603 T15167 T15164 expl there,is
R4604 T15168 T15169 advmod very,little
R4605 T14973 T14974 det a,failure
R4606 T14974 T14972 pobj failure,to
R4607 T15169 T15170 amod little,mesenchyme
R4608 T15170 T15164 attr mesenchyme,is
R4609 T14975 T14974 prep of,failure
R4610 T15171 T15172 punct ", ",any
R4611 T15172 T15169 parataxis any,little
R4612 T15173 T15172 mark if,any
R4613 T14976 T14975 pobj addition,of
R4614 T15174 T15172 punct ", ",any
R4615 T15175 T15170 amod detectable,mesenchyme
R4616 T14977 T14976 prep of,addition
R4617 T15176 T15170 amod septal,mesenchyme
R4618 T15177 T15170 amod present,mesenchyme
R4619 T14978 T14977 pobj myocardium,of
R4620 T15178 T15164 punct ", ",is
R4621 T15179 T15164 cc and,is
R4622 T14979 T14976 prep from,addition
R4623 T15180 T15181 advmod thus,argued
R4624 T15181 T15164 conj argued,is
R4625 T15182 T15181 nsubjpass it,argued
R4626 T15183 T15181 aux could,argued
R4627 T15184 T15181 auxpass be,argued
R4628 T14980 T14981 det the,field
R4629 T15185 T15186 mark that,fails
R4630 T15186 T15181 ccomp fails,argued
R4631 T15187 T15186 prep in,fails
R4632 T15188 T15189 det these,mutants
R4633 T14981 T14979 pobj field,from
R4634 T15189 T15187 pobj mutants,in
R4635 T15190 T15191 compound OFT,rotation
R4636 T14982 T14981 amod secondary,field
R4637 T15191 T15186 nsubj rotation,fails
R4638 T15192 T15186 prep due,fails
R4639 T15193 T15192 pcomp to,due
R4640 T14983 T14981 compound heart,field
R4641 T15194 T15195 det a,lack
R4642 T15195 T15192 pobj lack,due
R4643 T15196 T15195 prep of,lack
R4644 T14984 T14985 punct [,40
R4645 T15197 T15196 pobj penetration,of
R4646 T15198 T15197 prep of,penetration
R4647 T15199 T15200 amod septal,prongs
R4648 T14985 T14968 parataxis 40,lead
R4649 T15200 T15198 pobj prongs,of
R4650 T15201 T15197 prep into,penetration
R4651 T15202 T15203 det the,mesenchyme
R4652 T14986 T14985 punct ],40
R4653 T15203 T15201 pobj mesenchyme,into
R4654 T15204 T15203 compound cushion,mesenchyme
R4655 T15205 T15181 punct .,argued
R4656 T14987 T14961 punct .,shown
R4657 T14989 T14990 nsubjpass It,suggested
R4658 T14991 T14990 auxpass was,suggested
R4659 T15207 T15208 prep In,seen
R4660 T14992 T14993 mark that,resulted
R4661 T15209 T15207 pobj contrast,In
R4662 T15210 T15208 punct ", ",seen
R4663 T14993 T14990 ccomp resulted,suggested
R4664 T15211 T15208 prep in,seen
R4665 T15212 T15213 compound Alk2,Cre
R4666 T15213 T15217 compound Cre,mutants
R4667 T14994 T14995 det the,migration
R4668 T15214 T15213 punct /,Cre
R4669 T15215 T15213 compound Wnt1,Cre
R4670 T15216 T15213 punct -,Cre
R4671 T15217 T15211 pobj mutants,in
R4672 T15218 T15219 det a,mesenchyme
R4673 T15219 T15208 nsubjpass mesenchyme,seen
R4674 T15220 T15219 amod sizeable,mesenchyme
R4675 T15221 T15219 amod septal,mesenchyme
R4676 T15222 T15208 aux could,seen
R4677 T15223 T15208 auxpass be,seen
R4678 T15224 T15208 punct ", ",seen
R4679 T15225 T15226 advmod still,without
R4680 T15226 T15208 prep without,seen
R4681 T15227 T15228 det any,looping
R4682 T15228 T15226 pobj looping,without
R4683 T15229 T15228 amod obvious,looping
R4684 T15230 T15228 prep of,looping
R4685 T15231 T15232 det the,sac
R4686 T15232 T15230 pobj sac,of
R4687 T15233 T15232 amod aortic,sac
R4688 T15234 T15232 cc and,sac
R4689 T15235 T15236 amod truncal,OFT
R4690 T15236 T15232 conj OFT,sac
R4691 T15237 T15208 punct ", ",seen
R4692 T15238 T15208 advcl suggesting,seen
R4693 T15239 T15240 mark that,is
R4695 T15241 T15242 det the,presence
R4696 T15242 T15240 nsubj presence,is
R4697 T15243 T15242 amod mere,presence
R4698 T15244 T15242 prep of,presence
R4699 T15245 T15246 det the,mesenchyme
R4700 T15246 T15244 pobj mesenchyme,of
R4701 T15247 T15246 amod septal,mesenchyme
R4702 T15248 T15242 punct ", ",presence
R4703 T15249 T15242 prep without,presence
R4704 T15250 T15251 amod correct,differentiation
R4706 T15252 T15253 amod smooth,muscle
R4707 T15253 T15251 compound muscle,differentiation
R4694 T15240 T15238 ccomp is,suggesting
R4705 T15251 T15249 pobj differentiation,without
R4708 T15254 T15251 compound cell,differentiation
R4709 T15255 T15240 punct ", ",is
R4710 T15256 T15240 neg not,is
R4711 T15257 T15240 acomp sufficient,is
R4712 T15258 T15257 prep for,sufficient
R4713 T15259 T15260 compound OFT,rotation
R4714 T15260 T15258 pobj rotation,for
R4715 T15261 T15208 punct .,seen

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13673 41-45 PR_EXT:000017435 denotes Wnt1
T13674 50-60 SO_EXT:transgenic_entity denotes transgenic
T13675 110-116 UBERON:0000479 denotes tissue
T13676 126-130 SO_EXT:0000704 denotes gene
T13677 131-139 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T13678 143-147 CL_EXT:neural_crest_cell denotes NCCs
T13679 234-236 UBERON:0002342 denotes NC
T13680 246-254 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T13681 262-268 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T13682 269-273 SO_EXT:0000704 denotes gene
T13683 301-310 UBERON:0004339 denotes calvarial
T13684 312-318 UBERON:0001456 denotes facial
T13685 323-330 UBERON:0000948 denotes cardiac
T13686 416-428 UBERON_EXT:face_or_skull denotes craniofacial
T13687 433-443 UBERON:0006562 denotes pharyngeal
T13688 467-472 UBERON:0000948 denotes heart
T13689 509-516 SO_EXT:sequence_altered_entity denotes mutants
T13690 520-524 PR_EXT:000000047 denotes Alk5
T13691 532-539 SO_EXT:sequence_coding_function denotes encodes
T13692 544-565 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_I denotes TGF-β type I receptor
T13693 582-589 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T13694 601-609 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes TGF-βRII
T13695 645-651 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T13696 652-656 PR_EXT:000017435 denotes Wnt1
T13697 661-668 SO_EXT:sequence_altered_entity denotes mutants
T13698 680-684 NCBITaxon:10088 denotes mice
T13699 698-704 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgf-β2
T13700 730-748 UBERON:0002061 denotes truncus arteriosus
T13701 766-777 UBERON:0001508 denotes aortic arch
T13702 785-789 PR_EXT:000000047 denotes Alk5
T13703 790-794 PR_EXT:000017435 denotes Wnt1
T13704 799-806 SO_EXT:sequence_altered_entity denotes mutants
T13705 841-851 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T13706 867-871 UBERON:0004363 denotes PAAs
T13707 926-930 UBERON:0004363 denotes PAAs
T13708 946-950 PR_EXT:000000047 denotes Alk5
T13709 951-955 PR_EXT:000017435 denotes Wnt1
T13710 960-967 SO_EXT:sequence_altered_entity denotes mutants
T13711 988-998 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T13712 1006-1016 UBERON:0005432 denotes aortic sac
T13713 1086-1103 UBERON:0002061 denotes truncus artriosus
T13714 1117-1133 UBERON:0002012 denotes pulmonary artery
T13715 1230-1240 UBERON:0005432 denotes aortic sac
T13716 1287-1294 UBERON:0002061 denotes truncal
T13717 1352-1360 UBERON:0003121 denotes 4th PAAs
T13718 1388-1399 UBERON:0004363 denotes aortic arch
T13719 1458-1470 _FRAGMENT denotes apoptosis of
T13720 1514-1519 GO:0006915 denotes cells
T13721 1471-1475 PR_EXT:000000047 denotes Alk5
T13722 1491-1500 GO_EXT:biological_movement_or_translocation_process denotes migratory
T13723 1501-1513 UBERON:0002342 denotes neural crest
T13724 1501-1519 CL_EXT:neural_crest_cell denotes neural crest cells
T13725 1514-1519 CL_GO_EXT:cell denotes cells
T13726 1583-1587 CL_GO_EXT:cell denotes cell
T13727 1583-1593 GO:0008219 denotes cell death
T13728 1619-1625 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T13729 1626-1630 PR_EXT:000017435 denotes Wnt1
T13730 1635-1642 SO_EXT:sequence_altered_entity denotes mutants
T13731 1686-1691 PR_EXT:000000046 denotes TGF-β
T13732 1686-1701 GO:0007179 denotes TGF-β signaling
T13733 1705-1712 UBERON:0000948 denotes cardiac
T13734 1713-1717 CL_EXT:neural_crest_cell denotes NCCs
T13735 1752-1756 PR_EXT:000000047 denotes ALK5
T13736 1757-1774 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes TGF-βRII receptor
T13737 1766-1782 GO:0043235 denotes receptor complex
T13738 1784-1788 PR_EXT:000000047 denotes ALK5
T13739 1803-1812 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T13740 1830-1837 CHEBI_GO_EXT:ligand denotes ligands
T13741 1904-1907 CL_EXT:neural_crest_cell denotes NCC
T13742 1959-1967 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes TGF-βRII
T13743 1969-1973 PR_EXT:000000047 denotes ALK5
T13744 1990-1997 GO:0032991 denotes complex
T13745 2007-2014 GO:0048180 denotes Activin
T13746 2007-2032 PR_EXT:000000071 denotes Activin type IIB receptor
T13747 2024-2032 GO_EXT:0004872 denotes receptor
T13748 2056-2061 GO_PR_EXT:SMAD denotes Smads
T13749 2056-2063 PR_EXT:000000364 denotes Smads 2
T13750 2056-2061 _FRAGMENT denotes Smads
T13751 2064-2065 PR_EXT:000000365 denotes 3
T13752 2100-2105 PR_EXT:000000046 denotes TGF-β
T13753 2114-2120 GO_EXT:biological_growth_entity_or_process denotes growth
T13754 2114-2120 _FRAGMENT denotes growth
T13755 2141-2148 GO_EXT:0008083 denotes factors
T13756 2125-2140 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T13757 2163-2167 PR_EXT:000010684 denotes GDF8
T13758 2169-2173 PR_EXT:000007925 denotes GDF9
T13759 2175-2180 PR_EXT:000007919 denotes GDF11
T13760 2185-2190 PR_EXT:000007920 denotes GDF15
T13761 2250-2256 PR_EXT:000010684 denotes Gdfs 8
T13762 2250-2254 _FRAGMENT denotes Gdfs
T13763 2258-2259 PR_EXT:000007925 denotes 9
T13764 2260-2262 PR_EXT:000007919 denotes 11
T13765 2267-2269 PR_EXT:000007920 denotes 15
T13766 2278-2287 GO:0010467 denotes expressed
T13767 2306-2311 UBERON:0000948 denotes heart
T13768 2324-2328 NCBITaxon:10088 denotes mice
T13769 2375-2382 UBERON:0000948 denotes cardiac
T13770 2473-2479 PR_EXT:000000046 denotes TGF-βs
T13771 2498-2501 CL_EXT:neural_crest_cell denotes NCC
T13772 2518-2525 UBERON:0000948 denotes cardiac
T13773 2518-2525 _FRAGMENT denotes cardiac
T13774 2541-2554 GO:0003007 denotes morphogenesis
T13775 2530-2540 UBERON:0006562 denotes pharyngeal
T13776 2580-2589 GO:0006915 denotes apoptosis
T13777 2610-2620 UBERON:0005432 denotes aortic sac
T13778 2632-2641 UBERON:0006207 denotes AP-septum
T13779 2671-2674 _FRAGMENT denotes 4th
T13780 2683-2687 UBERON:0003121 denotes PAAs
T13781 2679-2687 UBERON:0003123 denotes 6th PAAs
T13782 2728-2737 GO:0006915 denotes apoptosis
T13783 2752-2761 GO_EXT:biological_movement_or_translocation_process denotes migratory
T13784 2762-2766 CL_EXT:neural_crest_cell denotes NCCs
T13785 2774-2784 UBERON:0003104 denotes mesenchyme
T13786 2801-2811 UBERON:0005432 denotes aortic sac
T13787 2846-2855 UBERON:0006207 denotes AP septum
T13788 2874-2878 CL_GO_EXT:cell denotes cell
T13789 2874-2884 GO:0008219 denotes cell death
T13790 2898-2907 UBERON:0006207 denotes AP septal
T13791 2923-2930 SO_EXT:sequence_altered_entity denotes mutants
T13792 2946-2948 UBERON:0002342 denotes NC
T13793 2957-2962 CL_GO_EXT:cell denotes cells
T13794 2978-2993 GO_RO_EXT:developmental_differentiation_process denotes differentiating
T13795 2997-3010 UBERON:0001135 denotes smooth muscle
T13796 2997-3016 CL:0000192 denotes smooth muscle cells
T13797 3011-3016 CL_GO_EXT:cell denotes cells
T13798 3024-3027 UBERON:0004145 denotes OFT
T13799 3064-3073 UBERON:0006207 denotes AP septum
T13800 3085-3089 PR_EXT:000000047 denotes Alk5
T13801 3090-3094 PR_EXT:000017435 denotes Wnt1
T13802 3099-3106 SO_EXT:sequence_altered_entity denotes mutants
T13803 3172-3177 CL_GO_EXT:cell denotes cells
T13804 3190-3199 UBERON:0006207 denotes AP septum
T13805 3228-3232 CL_GO_EXT:cell denotes cell
T13806 3228-3238 GO:0008219 denotes cell death
T13807 3274-3279 CL_GO_EXT:cell denotes cells
T13808 3292-3301 UBERON:0006207 denotes AP-septum
T13809 3302-3305 GO:0016265 denotes die
T13810 3338-3351 GO_RO_EXT:developmental_differentiation_process denotes differentiate
T13811 3355-3368 UBERON:0001135 denotes smooth muscle
T13812 3355-3374 CL:0000192 denotes smooth muscle cells
T13813 3369-3374 CL_GO_EXT:cell denotes cells
T13814 3442-3447 PR_EXT:000000046 denotes TGF-β
T13815 3442-3457 GO:0007179 denotes TGF-β-signaling
T13816 3461-3476 _FRAGMENT denotes differentiation
T13817 3485-3509 GO:0051145 denotes into smooth muscle cells
T13818 3480-3484 CL_EXT:neural_crest_cell denotes NCCs
T13819 3490-3503 UBERON:0001135 denotes smooth muscle
T13820 3490-3509 CL:0000192 denotes smooth muscle cells
T13821 3504-3509 CL_GO_EXT:cell denotes cells
T13822 3559-3563 NCBITaxon:10088 denotes mice
T13823 5923-5925 UBERON:0002342 denotes NC
T13824 3572-3578 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T13825 3606-3609 CL_EXT:neural_crest_cell denotes NCC
T13826 3610-3630 _FRAGMENT denotes differentiation into
T13827 3645-3650 GO:0030154 denotes cells
T13828 3631-3635 PR_EXT:000003675 denotes αSMA
T13829 3645-3650 CL_GO_EXT:cell denotes cells
T13830 3658-3667 UBERON:0006207 denotes AP septum
T13831 3771-3775 PR_EXT:000003675 denotes αSMA
T13832 3783-3786 UBERON:0004145 denotes OFT
T13833 3819-3828 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T13834 3833-3837 PR_EXT:000000047 denotes ALK5
T13835 3858-3871 UBERON:0001135 denotes smooth muscle
T13836 3872-3887 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T13837 3934-3942 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T13838 3946-3952 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II denotes Tgfbr2
T13839 3956-3960 CL_EXT:neural_crest_cell denotes NCCs
T13840 4090-4098 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T13841 4134-4140 _FRAGMENT denotes region
T13842 4148-4161 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes on chromosome
T13843 4259-4263 PR_EXT:000000047 denotes Alk5
T13844 4264-4268 PR_EXT:000017435 denotes Wnt1
T13845 4273-4280 SO_EXT:sequence_altered_entity denotes mutants
T13846 4365-4367 UBERON:0002342 denotes NC
T13847 4391-4395 PR_EXT:000000047 denotes Alk5
T13848 4457-4467 UBERON:0006562 denotes pharyngeal
T13849 4468-4473 UBERON:0000062 denotes organ
T13850 4474-4483 GO_EXT:biological_movement_or_translocation_process denotes migration
T13851 4493-4497 PR_EXT:000000047 denotes Alk5
T13852 4498-4502 PR_EXT:000017435 denotes Wnt1
T13853 4507-4514 SO_EXT:sequence_altered_entity denotes mutants
T13854 4549-4560 UBERON:0003104 denotes mesenchymal
T13855 4549-4565 CL:0000134 denotes mesenchymal cell
T13856 4561-4565 CL_GO_EXT:cell denotes cell
T13857 4561-4571 GO:0008219 denotes cell death
T13858 4579-4589 UBERON:0006562 denotes pharyngeal
T13859 4607-4613 UBERON:0002370 denotes thymus
T13860 4615-4622 UBERON:0002046 denotes thyroid
T13861 4627-4638 UBERON:0001132 denotes parathyroid
T13862 4710-4717 SO_EXT:sequence_altered_entity denotes mutants
T13863 4733-4736 CL_EXT:neural_crest_cell denotes NCC
T13864 4737-4742 GO:0016265 denotes death
T13865 4751-4755 PR_EXT:000000047 denotes Alk5
T13866 4756-4763 SO_EXT:sequence_altered_entity denotes mutants
T13867 4792-4801 GO_EXT:biological_movement_or_translocation_process denotes migratory
T13868 4816-4820 CL_EXT:neural_crest_cell denotes NCCs
T13869 4828-4833 SO_EXT:0000704 denotes genes
T13870 4861-4865 PR_EXT:000016143 denotes Tbx1
T13871 4870-4874 PR_EXT:000005883 denotes CrkL
T13872 4876-4883 GO:0065007 denotes control
T13873 4884-4887 CL_EXT:neural_crest_cell denotes NCC
T13874 4920-4930 GO:0065007 denotes regulating
T13875 4931-4944 GO:0008283 denotes proliferation
T13876 4952-4973 UBERON:0009889 denotes secondary heart field
T13877 4975-4978 UBERON:0009889 denotes SHF
T13878 4985-4993 UBERON:0000925 denotes endoderm
T13879 5048-5052 CL_EXT:neural_crest_cell denotes NCCs
T13880 5083-5093 UBERON:0006562 denotes pharyngeal
T13881 5110-5113 CL_EXT:neural_crest_cell denotes NCC
T13882 5130-5135 NCBITaxon_UBERON_EXT:chick denotes chick
T13883 5198-5208 UBERON:0002349 denotes myocardium
T13884 5218-5239 UBERON:0009889 denotes secondary heart field
T13885 5282-5300 GO:0016477 denotes migration of cells
T13886 5295-5300 CL_GO_EXT:cell denotes cells
T13887 5310-5331 UBERON:0009889 denotes secondary heart field
T13888 5339-5342 UBERON:0004145 denotes OFT
T13889 5408-5411 UBERON:0004145 denotes OFT
T13890 5445-5453 UBERON:0001637 denotes arterial
T13891 5468-5478 UBERON:0002082 denotes ventricles
T13892 5504-5507 UBERON:0004145 denotes OFT
T13893 5521-5525 PR_EXT:000000047 denotes Alk5
T13894 5526-5530 PR_EXT:000017435 denotes Wnt1
T13895 5535-5542 SO_EXT:sequence_altered_entity denotes mutants
T13896 5590-5595 NCBITaxon_UBERON_EXT:chick denotes chick
T13897 5596-5598 UBERON:0002342 denotes NC
T13898 5646-5656 UBERON:0005432 denotes aortic sac
T13899 5695-5716 UBERON:0009889 denotes secondary heart field
T13900 5745-5749 PR_EXT:000000047 denotes Alk5
T13901 5750-5757 SO_EXT:sequence_altered_entity denotes mutants
T13902 5830-5833 UBERON:0004145 denotes OFT
T13903 5837-5849 UBERON:0002342 denotes neural crest
T13904 5859-5866 SO_EXT:sequence_altered_entity denotes mutants
T13905 5870-5874 PR_EXT:000000047 denotes Alk5
T13906 5878-5882 PR_EXT:000000067 denotes Alk2
T13907 5900-5905 CL_GO_EXT:cell denotes cells
T13908 5953-5956 UBERON:0009889 denotes SHF
T13909 5991-5994 UBERON:0004145 denotes OFT
T13910 6007-6011 NCBITaxon:10088 denotes mice
T13911 6048-6053 _FRAGMENT denotes TGF-β
T13912 6058-6074 GO_PR_EXT:transforming_growth_factor_beta_receptor_type_I denotes type I receptors
T13913 6054-6074 PR_EXT:BMP_type_1_receptor denotes BMP type I receptors
T13914 6089-6092 UBERON:0004145 denotes OFT
T13915 6135-6139 PR_EXT:000000047 denotes Alk5
T13916 6140-6147 SO_EXT:sequence_altered_entity denotes mutants
T13917 6189-6195 UBERON:0003037 denotes septal
T13918 6196-6206 UBERON:0003104 denotes mesenchyme
T13919 6258-6265 SO_EXT:sequence_altered_entity denotes mutants
T13920 6266-6269 UBERON:0004145 denotes OFT
T13921 6317-6323 UBERON:0003037 denotes septal
T13922 6348-6358 UBERON:0003104 denotes mesenchyme
T13923 6376-6380 PR_EXT:000000067 denotes Alk2
T13924 6381-6385 PR_EXT:000017435 denotes Wnt1
T13925 6390-6397 SO_EXT:sequence_altered_entity denotes mutants
T13926 6409-6415 UBERON:0003037 denotes septal
T13927 6416-6426 UBERON:0003104 denotes mesenchyme
T13928 6468-6475 GO:0001947 denotes looping
T13929 6483-6493 UBERON:0005432 denotes aortic sac
T13930 6498-6505 UBERON:0002061 denotes truncal
T13931 6506-6509 UBERON:0004145 denotes OFT
T13932 6552-6558 UBERON:0003037 denotes septal
T13933 6559-6569 UBERON:0003104 denotes mesenchyme
T13934 6587-6600 UBERON:0001135 denotes smooth muscle
T13935 6587-6605 CL:0000192 denotes smooth muscle cell
T13936 6601-6605 CL_GO_EXT:cell denotes cell
T13937 6601-6621 GO:0030154 denotes cell differentiation
T13938 6645-6648 UBERON:0004145 denotes OFT
R3440 T13720 T13719 _lexicallyChainedTo cells,apoptosis of
R3441 T13751 T13750 _lexicallyChainedTo 3,Smads
R3442 T13755 T13754 _lexicallyChainedTo factors,growth
R3443 T13763 T13762 _lexicallyChainedTo 9,Gdfs
R3444 T13764 T13762 _lexicallyChainedTo 11,Gdfs
R3445 T13765 T13762 _lexicallyChainedTo 15,Gdfs
R3446 T13774 T13773 _lexicallyChainedTo morphogenesis,cardiac
R3447 T13780 T13779 _lexicallyChainedTo PAAs,4th
R3448 T13817 T13816 _lexicallyChainedTo into smooth muscle cells,differentiation
R3449 T13827 T13826 _lexicallyChainedTo cells,differentiation into
R3450 T13842 T13841 _lexicallyChainedTo on chromosome,region
R3451 T13912 T13911 _lexicallyChainedTo type I receptors,TGF-β

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13492 41-45 PR:000017435 denotes Wnt1
T13493 110-116 UBERON:0000479 denotes tissue
T13494 126-130 SO:0000704 denotes gene
T13495 234-236 UBERON:0002342 denotes NC
T13496 269-273 SO:0000704 denotes gene
T13497 301-310 UBERON:0004339 denotes calvarial
T13498 312-318 UBERON:0001456 denotes facial
T13499 323-330 UBERON:0000948 denotes cardiac
T13500 433-443 UBERON:0006562 denotes pharyngeal
T13501 467-472 UBERON:0000948 denotes heart
T13502 520-524 PR:000000047 denotes Alk5
T13503 544-549 PR:000000046 denotes TGF-β
T13504 652-656 PR:000017435 denotes Wnt1
T13505 680-684 NCBITaxon:10088 denotes mice
T13506 698-704 PR:000000183 denotes Tgf-β2
T13507 730-748 UBERON:0002061 denotes truncus arteriosus
T13508 766-777 UBERON:0001508 denotes aortic arch
T13509 785-789 PR:000000047 denotes Alk5
T13510 790-794 PR:000017435 denotes Wnt1
T13511 867-871 UBERON:0004363 denotes PAAs
T13512 926-930 UBERON:0004363 denotes PAAs
T13513 946-950 PR:000000047 denotes Alk5
T13514 951-955 PR:000017435 denotes Wnt1
T13515 1006-1016 UBERON:0005432 denotes aortic sac
T13516 1086-1103 UBERON:0002061 denotes truncus artriosus
T13517 1117-1133 UBERON:0002012 denotes pulmonary artery
T13518 1230-1240 UBERON:0005432 denotes aortic sac
T13519 1287-1294 UBERON:0002061 denotes truncal
T13520 1352-1360 UBERON:0003121 denotes 4th PAAs
T13521 1388-1399 UBERON:0004363 denotes aortic arch
T13522 1458-1470 _FRAGMENT denotes apoptosis of
T13523 1514-1519 GO:0006915 denotes cells
T13524 1471-1475 PR:000000047 denotes Alk5
T13525 1501-1513 UBERON:0002342 denotes neural crest
T13526 1583-1593 GO:0008219 denotes cell death
T13527 1626-1630 PR:000017435 denotes Wnt1
T13528 1686-1691 PR:000000046 denotes TGF-β
T13529 1686-1701 GO:0007179 denotes TGF-β signaling
T13530 1705-1712 UBERON:0000948 denotes cardiac
T13531 1752-1756 PR:000000047 denotes ALK5
T13532 1766-1782 GO:0043235 denotes receptor complex
T13533 1784-1788 PR:000000047 denotes ALK5
T13534 1969-1973 PR:000000047 denotes ALK5
T13535 1990-1997 GO:0032991 denotes complex
T13536 2007-2014 GO:0048180 denotes Activin
T13537 2007-2032 PR:000000071 denotes Activin type IIB receptor
T13538 2056-2063 PR:000000364 denotes Smads 2
T13539 2056-2061 _FRAGMENT denotes Smads
T13540 2064-2065 PR:000000365 denotes 3
T13541 2100-2105 PR:000000046 denotes TGF-β
T13542 2163-2167 PR:000010684 denotes GDF8
T13543 2169-2173 PR:000007925 denotes GDF9
T13544 2175-2180 PR:000007919 denotes GDF11
T13545 2185-2190 PR:000007920 denotes GDF15
T13546 2250-2256 PR:000010684 denotes Gdfs 8
T13547 2250-2254 _FRAGMENT denotes Gdfs
T13548 2258-2259 PR:000007925 denotes 9
T13549 2260-2262 PR:000007919 denotes 11
T13550 2267-2269 PR:000007920 denotes 15
T13551 2278-2287 GO:0010467 denotes expressed
T13552 2306-2311 UBERON:0000948 denotes heart
T13553 2324-2328 NCBITaxon:10088 denotes mice
T13554 2375-2382 UBERON:0000948 denotes cardiac
T13555 2473-2479 PR:000000046 denotes TGF-βs
T13556 2518-2525 UBERON:0000948 denotes cardiac
T13557 2518-2525 _FRAGMENT denotes cardiac
T13558 2541-2554 GO:0003007 denotes morphogenesis
T13559 2530-2540 UBERON:0006562 denotes pharyngeal
T13560 2580-2589 GO:0006915 denotes apoptosis
T13561 2610-2620 UBERON:0005432 denotes aortic sac
T13562 2632-2641 UBERON:0006207 denotes AP-septum
T13563 2671-2674 _FRAGMENT denotes 4th
T13564 2683-2687 UBERON:0003121 denotes PAAs
T13565 2679-2687 UBERON:0003123 denotes 6th PAAs
T13566 2728-2737 GO:0006915 denotes apoptosis
T13567 2774-2784 UBERON:0003104 denotes mesenchyme
T13568 2801-2811 UBERON:0005432 denotes aortic sac
T13569 2846-2855 UBERON:0006207 denotes AP septum
T13570 2874-2884 GO:0008219 denotes cell death
T13571 2898-2907 UBERON:0006207 denotes AP septal
T13572 2946-2948 UBERON:0002342 denotes NC
T13573 2997-3010 UBERON:0001135 denotes smooth muscle
T13574 2997-3016 CL:0000192 denotes smooth muscle cells
T13575 3024-3027 UBERON:0004145 denotes OFT
T13576 3064-3073 UBERON:0006207 denotes AP septum
T13577 3085-3089 PR:000000047 denotes Alk5
T13578 3090-3094 PR:000017435 denotes Wnt1
T13579 3190-3199 UBERON:0006207 denotes AP septum
T13580 3228-3238 GO:0008219 denotes cell death
T13581 3292-3301 UBERON:0006207 denotes AP-septum
T13582 3302-3305 GO:0016265 denotes die
T13583 3355-3368 UBERON:0001135 denotes smooth muscle
T13584 3355-3374 CL:0000192 denotes smooth muscle cells
T13585 3442-3447 PR:000000046 denotes TGF-β
T13586 3442-3457 GO:0007179 denotes TGF-β-signaling
T13587 3461-3476 _FRAGMENT denotes differentiation
T13588 3485-3509 GO:0051145 denotes into smooth muscle cells
T13589 3490-3503 UBERON:0001135 denotes smooth muscle
T13590 3490-3509 CL:0000192 denotes smooth muscle cells
T13591 3559-3563 NCBITaxon:10088 denotes mice
T13592 3610-3630 _FRAGMENT denotes differentiation into
T13593 3645-3650 GO:0030154 denotes cells
T13594 3631-3635 PR:000003675 denotes αSMA
T13595 3658-3667 UBERON:0006207 denotes AP septum
T13596 3771-3775 PR:000003675 denotes αSMA
T13597 3783-3786 UBERON:0004145 denotes OFT
T13598 3833-3837 PR:000000047 denotes ALK5
T13599 3858-3871 UBERON:0001135 denotes smooth muscle
T13600 4259-4263 PR:000000047 denotes Alk5
T13601 4264-4268 PR:000017435 denotes Wnt1
T13602 4365-4367 UBERON:0002342 denotes NC
T13603 4391-4395 PR:000000047 denotes Alk5
T13604 4457-4467 UBERON:0006562 denotes pharyngeal
T13605 4468-4473 UBERON:0000062 denotes organ
T13606 4493-4497 PR:000000047 denotes Alk5
T13607 4498-4502 PR:000017435 denotes Wnt1
T13608 4549-4560 UBERON:0003104 denotes mesenchymal
T13609 4549-4565 CL:0000134 denotes mesenchymal cell
T13610 4561-4571 GO:0008219 denotes cell death
T13611 4579-4589 UBERON:0006562 denotes pharyngeal
T13612 4607-4613 UBERON:0002370 denotes thymus
T13613 4615-4622 UBERON:0002046 denotes thyroid
T13614 4627-4638 UBERON:0001132 denotes parathyroid
T13615 4737-4742 GO:0016265 denotes death
T13616 4751-4755 PR:000000047 denotes Alk5
T13617 4828-4833 SO:0000704 denotes genes
T13618 4861-4865 PR:000016143 denotes Tbx1
T13619 4870-4874 PR:000005883 denotes CrkL
T13620 4876-4883 GO:0065007 denotes control
T13621 4920-4930 GO:0065007 denotes regulating
T13622 4931-4944 GO:0008283 denotes proliferation
T13623 4952-4973 UBERON:0009889 denotes secondary heart field
T13624 4975-4978 UBERON:0009889 denotes SHF
T13625 4985-4993 UBERON:0000925 denotes endoderm
T13626 5083-5093 UBERON:0006562 denotes pharyngeal
T13627 5198-5208 UBERON:0002349 denotes myocardium
T13628 5218-5239 UBERON:0009889 denotes secondary heart field
T13629 5282-5300 GO:0016477 denotes migration of cells
T13630 5310-5331 UBERON:0009889 denotes secondary heart field
T13631 5339-5342 UBERON:0004145 denotes OFT
T13632 5408-5411 UBERON:0004145 denotes OFT
T13633 5445-5453 UBERON:0001637 denotes arterial
T13634 5468-5478 UBERON:0002082 denotes ventricles
T13635 5504-5507 UBERON:0004145 denotes OFT
T13636 5521-5525 PR:000000047 denotes Alk5
T13637 5526-5530 PR:000017435 denotes Wnt1
T13638 5596-5598 UBERON:0002342 denotes NC
T13639 5646-5656 UBERON:0005432 denotes aortic sac
T13640 5695-5716 UBERON:0009889 denotes secondary heart field
T13641 5745-5749 PR:000000047 denotes Alk5
T13642 5830-5833 UBERON:0004145 denotes OFT
T13643 5837-5849 UBERON:0002342 denotes neural crest
T13644 5870-5874 PR:000000047 denotes Alk5
T13645 5878-5882 PR:000000067 denotes Alk2
T13646 5923-5925 UBERON:0002342 denotes NC
T13647 5953-5956 UBERON:0009889 denotes SHF
T13648 5991-5994 UBERON:0004145 denotes OFT
T13649 6007-6011 NCBITaxon:10088 denotes mice
T13650 6048-6053 PR:000000046 denotes TGF-β
T13651 6054-6057 PR:000000034 denotes BMP
T13652 6089-6092 UBERON:0004145 denotes OFT
T13653 6135-6139 PR:000000047 denotes Alk5
T13654 6189-6195 UBERON:0003037 denotes septal
T13655 6196-6206 UBERON:0003104 denotes mesenchyme
T13656 6266-6269 UBERON:0004145 denotes OFT
T13657 6317-6323 UBERON:0003037 denotes septal
T13658 6348-6358 UBERON:0003104 denotes mesenchyme
T13659 6376-6380 PR:000000067 denotes Alk2
T13660 6381-6385 PR:000017435 denotes Wnt1
T13661 6409-6415 UBERON:0003037 denotes septal
T13662 6416-6426 UBERON:0003104 denotes mesenchyme
T13663 6468-6475 GO:0001947 denotes looping
T13664 6483-6493 UBERON:0005432 denotes aortic sac
T13665 6498-6505 UBERON:0002061 denotes truncal
T13666 6506-6509 UBERON:0004145 denotes OFT
T13667 6552-6558 UBERON:0003037 denotes septal
T13668 6559-6569 UBERON:0003104 denotes mesenchyme
T13669 6587-6600 UBERON:0001135 denotes smooth muscle
T13670 6587-6605 CL:0000192 denotes smooth muscle cell
T13671 6601-6621 GO:0030154 denotes cell differentiation
T13672 6645-6648 UBERON:0004145 denotes OFT
R3431 T13523 T13522 _lexicallyChainedTo cells,apoptosis of
R3432 T13540 T13539 _lexicallyChainedTo 3,Smads
R3433 T13548 T13547 _lexicallyChainedTo 9,Gdfs
R3434 T13549 T13547 _lexicallyChainedTo 11,Gdfs
R3435 T13550 T13547 _lexicallyChainedTo 15,Gdfs
R3436 T13558 T13557 _lexicallyChainedTo morphogenesis,cardiac
R3437 T13564 T13563 _lexicallyChainedTo PAAs,4th
R3438 T13588 T13587 _lexicallyChainedTo into smooth muscle cells,differentiation
R3439 T13593 T13592 _lexicallyChainedTo cells,differentiation into