PMC:1635039 / 2207-3498 JSONTXT

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Mice deficient in TGF-β2 display fourth aortic arch artery defects [7], while neural crest cell specific abrogation of TGF-β type II receptor (Tgfbr2) results in interruption of the aortic arch and PTA [8,9]. BMPs 6 and -7 are required for proper formation of the outflow tract cushions [10], while BMP type II receptor is needed for proper development of the conotruncal ridges [11]. 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