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PMC:1635039 / 19779-20628 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T10168 838-839 HYPH denotes -
T10169 848-849 . denotes .
T20254 288-289 -LRB- denotes (
T20179 11-19 JJ denotes Aberrant
T20180 20-29 NN denotes apoptosis
T20181 30-32 IN denotes of
T20182 33-37 NNS denotes NCCs
T20183 38-40 IN denotes in
T20184 41-45 NN denotes Alk5
T20185 51-54 NN denotes Cre
T20186 45-46 HYPH denotes /
T20187 46-50 NN denotes Wnt1
T20188 50-51 HYPH denotes -
T20189 55-62 NNS denotes mutants
T20190 62-63 . denotes .
T20191 63-429 sentence denotes TUNEL (A-H) and Cleaved Caspase-3 (I, J) staining at E11.0 demonstrates a notable increase in apoptosis in Alk5/Wnt1-Cre mutants (B, H, J) on the aortic sac level when compared to controls (A, G, I) or Alk2/Wnt1-Cre mutants (C) (frontal sections), while sections on the OFT level do not demonstrate differences between controls (D) and Alk5 (E) or Alk2 (F) mutants.
T20192 64-69 NN denotes TUNEL
T20193 105-113 NN denotes staining
T20194 70-71 -LRB- denotes (
T20195 71-72 NN denotes A
T20196 72-73 SYM denotes -
T20197 73-74 NN denotes H
T20198 74-75 -RRB- denotes )
T20199 76-79 CC denotes and
T20200 80-87 VBN denotes Cleaved
T20201 88-95 NN denotes Caspase
T20202 95-96 HYPH denotes -
T20203 96-97 CD denotes 3
T20204 98-99 -LRB- denotes (
T20205 102-103 NN denotes J
T20206 99-100 NN denotes I
T20207 100-102 , denotes ,
T20208 103-104 -RRB- denotes )
T20209 123-135 VBZ denotes demonstrates
T20210 114-116 IN denotes at
T20211 117-122 NN denotes E11.0
T20212 136-137 DT denotes a
T20213 146-154 NN denotes increase
T20214 138-145 JJ denotes notable
T20215 155-157 IN denotes in
T20216 158-167 NN denotes apoptosis
T20217 168-170 IN denotes in
T20218 171-175 NN denotes Alk5
T20219 181-184 NN denotes Cre
T20220 175-176 HYPH denotes /
T20221 176-180 NN denotes Wnt1
T20222 180-181 HYPH denotes -
T20223 185-192 NNS denotes mutants
T20224 193-194 -LRB- denotes (
T20225 200-201 NN denotes J
T20226 194-195 NN denotes B
T20227 195-197 , denotes ,
T20228 197-198 NN denotes H
T20229 198-200 , denotes ,
T20230 201-202 -RRB- denotes )
T20231 203-205 IN denotes on
T20232 206-209 DT denotes the
T20233 221-226 NN denotes level
T20234 210-216 JJ denotes aortic
T20235 217-220 NN denotes sac
T20236 227-231 WRB denotes when
T20237 232-240 VBN denotes compared
T20238 241-243 IN denotes to
T20239 244-252 NNS denotes controls
T20240 253-254 -LRB- denotes (
T20241 260-261 NN denotes I
T20242 254-255 NN denotes A
T20243 255-257 , denotes ,
T20244 257-258 NN denotes G
T20245 258-260 , denotes ,
T20246 261-262 -RRB- denotes )
T20247 263-265 CC denotes or
T20248 266-270 NN denotes Alk2
T20249 276-279 NN denotes Cre
T20250 270-271 HYPH denotes /
T20251 271-275 NN denotes Wnt1
T20252 275-276 HYPH denotes -
T20253 280-287 NNS denotes mutants
T20255 289-290 NN denotes C
T20256 290-291 -RRB- denotes )
T20257 292-293 -LRB- denotes (
T20258 301-309 NNS denotes sections
T20259 293-300 JJ denotes frontal
T20260 309-310 -RRB- denotes )
T20261 310-312 , denotes ,
T20262 312-317 IN denotes while
T20263 351-362 VB denotes demonstrate
T20264 318-326 NNS denotes sections
T20265 327-329 IN denotes on
T20266 330-333 DT denotes the
T20267 338-343 NN denotes level
T20268 334-337 NN denotes OFT
T20269 344-346 VBP denotes do
T20270 347-350 RB denotes not
T20271 363-374 NNS denotes differences
T20272 375-382 IN denotes between
T20273 383-391 NNS denotes controls
T20274 392-393 -LRB- denotes (
T20275 393-394 NN denotes D
T20276 394-395 -RRB- denotes )
T20277 396-399 CC denotes and
T20278 400-404 NN denotes Alk5
T20279 421-428 NNS denotes mutants
T20280 405-406 -LRB- denotes (
T20281 406-407 NN denotes E
T20282 407-408 -RRB- denotes )
T20283 409-411 CC denotes or
T20284 412-416 NN denotes Alk2
T20285 417-418 -LRB- denotes (
T20286 418-419 NN denotes F
T20287 419-420 -RRB- denotes )
T20288 428-429 . denotes .
T20289 429-535 sentence denotes G,H, TUNEL staining of lacZ-stained embryos demonstrates that apoptotic cells are of neural crest origin.
T20290 430-431 LS denotes G
T20291 474-486 VBZ denotes demonstrates
T20292 431-432 , denotes ,
T20293 432-433 LS denotes H
T20294 433-435 , denotes ,
T20295 435-440 NN denotes TUNEL
T20296 441-449 NN denotes staining
T20297 450-452 IN denotes of
T20298 453-457 NN denotes lacZ
T20299 458-465 VBN denotes stained
T20300 457-458 HYPH denotes -
T20301 466-473 NNS denotes embryos
T20302 487-491 IN denotes that
T20303 508-511 VBP denotes are
T20304 492-501 JJ denotes apoptotic
T20305 502-507 NNS denotes cells
T20306 512-514 IN denotes of
T20307 515-521 JJ denotes neural
T20308 522-527 NN denotes crest
T20309 528-534 NN denotes origin
T20310 534-535 . denotes .
T20311 535-558 sentence denotes G, control; H, mutant.
T20312 536-537 NN denotes G
T20313 537-539 , denotes ,
T20314 539-546 NN denotes control
T20315 546-547 : denotes ;
T20316 548-549 NN denotes H
T20317 549-551 , denotes ,
T20318 551-557 NN denotes mutant
T20319 557-558 . denotes .
T20320 558-646 sentence denotes AS, aortic sac, arrows point to clusters of apoptotic cells surrounding the aortic sac.
T20321 559-561 JJ denotes AS
T20322 582-587 VBP denotes point
T20323 561-563 , denotes ,
T20324 563-569 JJ denotes aortic
T20325 570-573 NN denotes sac
T20326 573-575 , denotes ,
T20327 575-581 NNS denotes arrows
T20328 588-590 IN denotes to
T20329 591-599 NNS denotes clusters
T20330 600-602 IN denotes of
T20331 603-612 JJ denotes apoptotic
T20332 613-618 NNS denotes cells
T20333 619-630 VBG denotes surrounding
T20334 631-634 DT denotes the
T20335 642-645 NN denotes sac
T20336 635-641 JJ denotes aortic
T20337 645-646 . denotes .
T10129 0-849 sentence denotes Figure 7 Aberrant apoptosis of NCCs in Alk5/Wnt1-Cre mutants. TUNEL (A-H) and Cleaved Caspase-3 (I, J) staining at E11.0 demonstrates a notable increase in apoptosis in Alk5/Wnt1-Cre mutants (B, H, J) on the aortic sac level when compared to controls (A, G, I) or Alk2/Wnt1-Cre mutants (C) (frontal sections), while sections on the OFT level do not demonstrate differences between controls (D) and Alk5 (E) or Alk2 (F) mutants. G,H, TUNEL staining of lacZ-stained embryos demonstrates that apoptotic cells are of neural crest origin. G, control; H, mutant. AS, aortic sac, arrows point to clusters of apoptotic cells surrounding the aortic sac. To conclude, our results suggest that in Alk5/Wnt1-Cre mutants a noticeable increase in apoptosis coincides with the abnormal patterning of the PAAs and the aortic sac, and with the failed AP-septation.
T10130 647-649 TO denotes To
T10131 650-658 VB denotes conclude
T10132 672-679 VBP denotes suggest
T10133 658-660 , denotes ,
T10134 660-663 PRP$ denotes our
T10135 664-671 NNS denotes results
T10136 680-684 IN denotes that
T10137 745-754 VBZ denotes coincides
T10138 685-687 IN denotes in
T10139 688-692 NN denotes Alk5
T10140 698-701 NN denotes Cre
T10141 692-693 HYPH denotes /
T10142 693-697 NN denotes Wnt1
T10143 697-698 HYPH denotes -
T10144 702-709 NNS denotes mutants
T10145 710-711 DT denotes a
T10146 723-731 NN denotes increase
T10147 712-722 JJ denotes noticeable
T10148 732-734 IN denotes in
T10149 735-744 NN denotes apoptosis
T10150 755-759 IN denotes with
T10151 760-763 DT denotes the
T10152 773-783 NN denotes patterning
T10153 764-772 JJ denotes abnormal
T10154 784-786 IN denotes of
T10155 787-790 DT denotes the
T10156 791-795 NNS denotes PAAs
T10157 796-799 CC denotes and
T10158 800-803 DT denotes the
T10159 811-814 NN denotes sac
T10160 804-810 JJ denotes aortic
T10161 814-816 , denotes ,
T10162 816-819 CC denotes and
T10163 820-824 IN denotes with
T10164 825-828 DT denotes the
T10165 839-848 NN denotes septation
T10166 829-835 VBN denotes failed
T10167 836-838 NN denotes AP
R3086 T10133 T10132 punct ", ",suggest
R3087 T10134 T10135 poss our,results
R3088 T10135 T10132 nsubj results,suggest
R3089 T10136 T10137 mark that,coincides
R3090 T10137 T10132 ccomp coincides,suggest
R3091 T10138 T10137 prep in,coincides
R3092 T10139 T10140 compound Alk5,Cre
R3093 T10140 T10144 compound Cre,mutants
R3094 T10141 T10140 punct /,Cre
R3095 T10142 T10140 compound Wnt1,Cre
R3096 T10143 T10140 punct -,Cre
R3097 T10144 T10138 pobj mutants,in
R3098 T10145 T10146 det a,increase
R3099 T10146 T10137 nsubj increase,coincides
R3100 T10147 T10146 amod noticeable,increase
R3101 T10148 T10146 prep in,increase
R3102 T10149 T10148 pobj apoptosis,in
R3103 T10150 T10137 prep with,coincides
R3104 T10151 T10152 det the,patterning
R3105 T10152 T10150 pobj patterning,with
R3106 T10153 T10152 amod abnormal,patterning
R3107 T10154 T10152 prep of,patterning
R3108 T10155 T10156 det the,PAAs
R3109 T10156 T10154 pobj PAAs,of
R3110 T10157 T10156 cc and,PAAs
R3111 T10158 T10159 det the,sac
R3112 T10159 T10156 conj sac,PAAs
R3113 T10160 T10159 amod aortic,sac
R3114 T10161 T10150 punct ", ",with
R3115 T10162 T10150 cc and,with
R3116 T10163 T10150 conj with,with
R3117 T10164 T10165 det the,septation
R3118 T10165 T10163 pobj septation,with
R3119 T10166 T10165 amod failed,septation
R3120 T10167 T10165 compound AP,septation
R3121 T10168 T10165 punct -,septation
R3122 T10169 T10132 punct .,suggest
R6122 T20179 T20180 amod Aberrant,apoptosis
R6123 T20181 T20180 prep of,apoptosis
R6124 T20182 T20181 pobj NCCs,of
R6125 T20183 T20180 prep in,apoptosis
R6126 T20184 T20185 compound Alk5,Cre
R6127 T20185 T20189 compound Cre,mutants
R6128 T20186 T20185 punct /,Cre
R6129 T20187 T20185 compound Wnt1,Cre
R6130 T20188 T20185 punct -,Cre
R6131 T20189 T20183 pobj mutants,in
R6132 T20190 T20180 punct .,apoptosis
R6133 T20192 T20193 nmod TUNEL,staining
R6134 T20193 T20209 nsubj staining,demonstrates
R6135 T20194 T20195 punct (,A
R6136 T20195 T20192 parataxis A,TUNEL
R6137 T20196 T20197 punct -,H
R6138 T20197 T20195 prep H,A
R6139 T20198 T20195 punct ),A
R6140 T20199 T20192 cc and,TUNEL
R6141 T20200 T20201 amod Cleaved,Caspase
R6142 T20201 T20192 conj Caspase,TUNEL
R6143 T20202 T20201 punct -,Caspase
R6144 T20203 T20201 nummod 3,Caspase
R6145 T20204 T20205 punct (,J
R6146 T20205 T20201 parataxis J,Caspase
R6147 T20206 T20205 nmod I,J
R6148 T20207 T20205 punct ", ",J
R6149 T20208 T20205 punct ),J
R6150 T20210 T20193 prep at,staining
R6151 T20211 T20210 pobj E11.0,at
R6152 T20212 T20213 det a,increase
R6153 T20213 T20209 dobj increase,demonstrates
R6154 T20214 T20213 amod notable,increase
R6155 T20215 T20213 prep in,increase
R6156 T20216 T20215 pobj apoptosis,in
R6157 T20217 T20213 prep in,increase
R6158 T20218 T20219 compound Alk5,Cre
R6159 T20219 T20223 compound Cre,mutants
R6160 T20220 T20219 punct /,Cre
R6161 T20221 T20219 compound Wnt1,Cre
R6162 T20222 T20219 punct -,Cre
R6163 T20223 T20217 pobj mutants,in
R6164 T20224 T20225 punct (,J
R6165 T20225 T20223 parataxis J,mutants
R6166 T20226 T20225 nmod B,J
R6167 T20227 T20225 punct ", ",J
R6168 T20228 T20225 nmod H,J
R6169 T20229 T20225 punct ", ",J
R6170 T20230 T20225 punct ),J
R6171 T20231 T20213 prep on,increase
R6172 T20232 T20233 det the,level
R6173 T20233 T20231 pobj level,on
R6174 T20234 T20233 amod aortic,level
R6175 T20235 T20233 compound sac,level
R6176 T20236 T20237 advmod when,compared
R6177 T20237 T20213 advcl compared,increase
R6178 T20238 T20237 prep to,compared
R6179 T20239 T20238 pobj controls,to
R6180 T20240 T20241 punct (,I
R6181 T20241 T20239 parataxis I,controls
R6182 T20242 T20241 nmod A,I
R6183 T20243 T20241 punct ", ",I
R6184 T20244 T20241 nmod G,I
R6185 T20245 T20241 punct ", ",I
R6186 T20246 T20241 punct ),I
R6187 T20247 T20239 cc or,controls
R6188 T20248 T20249 compound Alk2,Cre
R6189 T20249 T20253 compound Cre,mutants
R6190 T20250 T20249 punct /,Cre
R6191 T20251 T20249 compound Wnt1,Cre
R6192 T20252 T20249 punct -,Cre
R6193 T20253 T20239 conj mutants,controls
R6194 T20254 T20255 punct (,C
R6195 T20255 T20253 parataxis C,mutants
R6196 T20256 T20255 punct ),C
R6197 T20257 T20258 punct (,sections
R6198 T20258 T20253 parataxis sections,mutants
R6199 T20259 T20258 amod frontal,sections
R6200 T20260 T20258 punct ),sections
R6201 T20261 T20209 punct ", ",demonstrates
R6202 T20262 T20263 mark while,demonstrate
R6203 T20263 T20209 advcl demonstrate,demonstrates
R6204 T20264 T20263 nsubj sections,demonstrate
R6205 T20265 T20264 prep on,sections
R6206 T20266 T20267 det the,level
R6207 T20267 T20265 pobj level,on
R6208 T20268 T20267 compound OFT,level
R6209 T20269 T20263 aux do,demonstrate
R6210 T20270 T20263 neg not,demonstrate
R6211 T20271 T20263 dobj differences,demonstrate
R6212 T20272 T20271 prep between,differences
R6213 T20273 T20272 pobj controls,between
R6214 T20274 T20275 punct (,D
R6215 T20275 T20273 parataxis D,controls
R6216 T20276 T20275 punct ),D
R6217 T20277 T20273 cc and,controls
R6218 T20278 T20279 nmod Alk5,mutants
R6219 T20279 T20273 conj mutants,controls
R6220 T20280 T20281 punct (,E
R6221 T20281 T20278 parataxis E,Alk5
R6222 T20282 T20281 punct ),E
R6223 T20283 T20278 cc or,Alk5
R6224 T20284 T20278 conj Alk2,Alk5
R6225 T20285 T20286 punct (,F
R6226 T20286 T20284 parataxis F,Alk2
R6227 T20287 T20286 punct ),F
R6228 T20288 T20209 punct .,demonstrates
R6229 T20290 T20291 meta G,demonstrates
R6230 T20292 T20290 punct ",",G
R6231 T20293 T20290 dep H,G
R6232 T20294 T20291 punct ", ",demonstrates
R6233 T20295 T20296 compound TUNEL,staining
R6234 T20296 T20291 nsubj staining,demonstrates
R6235 T20297 T20296 prep of,staining
R6236 T20298 T20299 npadvmod lacZ,stained
R6237 T20299 T20301 amod stained,embryos
R6238 T20300 T20299 punct -,stained
R6239 T20301 T20297 pobj embryos,of
R6240 T20302 T20303 mark that,are
R6241 T20303 T20291 ccomp are,demonstrates
R6242 T20304 T20305 amod apoptotic,cells
R6243 T20305 T20303 nsubj cells,are
R6244 T20306 T20303 prep of,are
R6245 T20307 T20308 amod neural,crest
R6246 T20308 T20309 compound crest,origin
R6247 T20309 T20306 pobj origin,of
R6248 T20310 T20291 punct .,demonstrates
R6249 T20313 T20312 punct ", ",G
R6250 T20314 T20312 appos control,G
R6251 T20315 T20312 punct ;,G
R6252 T20316 T20312 appos H,G
R6253 T20317 T20316 punct ", ",H
R6254 T20318 T20316 appos mutant,H
R6255 T20319 T20312 punct .,G
R6256 T20321 T20322 dep AS,point
R6257 T20323 T20321 punct ", ",AS
R6258 T20324 T20325 amod aortic,sac
R6259 T20325 T20321 appos sac,AS
R6260 T20326 T20322 punct ", ",point
R6261 T20327 T20322 nsubj arrows,point
R6262 T20328 T20322 prep to,point
R6263 T20329 T20328 pobj clusters,to
R6264 T20330 T20329 prep of,clusters
R6265 T20331 T20332 amod apoptotic,cells
R6266 T20332 T20330 pobj cells,of
R6267 T20333 T20329 acl surrounding,clusters
R6268 T20334 T20335 det the,sac
R6269 T20335 T20333 dobj sac,surrounding
R6270 T20336 T20335 amod aortic,sac
R6271 T20337 T20322 punct .,point
R3084 T10130 T10131 aux To,conclude
R3085 T10131 T10132 advcl conclude,suggest

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9821 688-692 PR_EXT:000000047 denotes Alk5
T9822 693-697 PR_EXT:000017435 denotes Wnt1
T9823 702-709 SO_EXT:sequence_altered_entity denotes mutants
T9824 735-744 GO:0006915 denotes apoptosis
T9825 773-783 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T9826 791-795 UBERON:0004363 denotes PAAs
T9827 804-814 UBERON:0005432 denotes aortic sac
T20145 20-29 GO:0006915 denotes apoptosis
T20146 33-37 CL_EXT:neural_crest_cell denotes NCCs
T20147 41-45 PR_EXT:000000047 denotes Alk5
T20148 46-50 PR_EXT:000017435 denotes Wnt1
T20149 55-62 SO_EXT:sequence_altered_entity denotes mutants
T20150 80-87 MOP:0000780 denotes Cleaved
T20151 80-97 PR_EXT:000018762 denotes Cleaved Caspase-3
T20152 158-167 GO:0006915 denotes apoptosis
T20153 171-175 PR_EXT:000000047 denotes Alk5
T20154 176-180 PR_EXT:000017435 denotes Wnt1
T20155 185-192 SO_EXT:sequence_altered_entity denotes mutants
T20156 210-220 UBERON:0005432 denotes aortic sac
T20157 266-270 PR_EXT:000000067 denotes Alk2
T20158 271-275 PR_EXT:000017435 denotes Wnt1
T20159 280-287 SO_EXT:sequence_altered_entity denotes mutants
T20160 334-337 UBERON:0004145 denotes OFT
T20161 400-404 PR_EXT:000000047 denotes Alk5
T20162 412-416 PR_EXT:000000067 denotes Alk2
T20163 421-428 SO_EXT:sequence_altered_entity denotes mutants
T20164 453-457 PR_EXT:000033987 denotes lacZ
T20165 466-473 UBERON:0000922 denotes embryos
T20166 492-501 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T20167 492-507 CL:0000445 denotes apoptotic cells
T20168 502-507 CL_GO_EXT:cell denotes cells
T20169 515-527 UBERON:0002342 denotes neural crest
T20170 551-557 SO_EXT:sequence_altered_entity denotes mutant
T20171 559-561 UBERON:0005432 denotes AS
T20172 563-573 UBERON:0005432 denotes aortic sac
T20173 591-602 _FRAGMENT denotes clusters of
T20174 613-618 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cells
T20175 603-612 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T20176 603-618 CL:0000445 denotes apoptotic cells
T20177 613-618 CL_GO_EXT:cell denotes cells
T20178 635-645 UBERON:0005432 denotes aortic sac
R6121 T20174 T20173 _lexicallyChainedTo cells,clusters of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9751 688-692 PR:000000047 denotes Alk5
T9752 693-697 PR:000017435 denotes Wnt1
T9753 735-744 GO:0006915 denotes apoptosis
T9754 791-795 UBERON:0004363 denotes PAAs
T9755 804-814 UBERON:0005432 denotes aortic sac
T20123 20-29 GO:0006915 denotes apoptosis
T20124 41-45 PR:000000047 denotes Alk5
T20125 46-50 PR:000017435 denotes Wnt1
T20126 80-87 MOP:0000780 denotes Cleaved
T20127 80-97 PR:000018762 denotes Cleaved Caspase-3
T20128 158-167 GO:0006915 denotes apoptosis
T20129 171-175 PR:000000047 denotes Alk5
T20130 176-180 PR:000017435 denotes Wnt1
T20131 210-220 UBERON:0005432 denotes aortic sac
T20132 266-270 PR:000000067 denotes Alk2
T20133 271-275 PR:000017435 denotes Wnt1
T20134 334-337 UBERON:0004145 denotes OFT
T20135 400-404 PR:000000047 denotes Alk5
T20136 412-416 PR:000000067 denotes Alk2
T20137 453-457 PR:000033987 denotes lacZ
T20138 466-473 UBERON:0000922 denotes embryos
T20139 492-507 CL:0000445 denotes apoptotic cells
T20140 515-527 UBERON:0002342 denotes neural crest
T20141 559-561 UBERON:0005432 denotes AS
T20142 563-573 UBERON:0005432 denotes aortic sac
T20143 603-618 CL:0000445 denotes apoptotic cells
T20144 635-645 UBERON:0005432 denotes aortic sac