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6 Signaling via ALK5 and ALK2 controls different aspects of aortico-pulmonary septation. Frontal sections from distal (top row) to proximal (bottom row) of the control (A-F), Alk5/Wnt1-Cre mutant (G-L) and Alk2/Wnt1-Cre mutant (M-R) samples (E11.5). A, C, E, G, I, K, M, O, Q, H\u0026E staining; B, D, F, H, J, L, N, P, R, double staining for αSMA (brown) and β-galactosidase (green; R26R reporter assay). 6, the 6th PAA; AS, aortic sac; TA, truncus arteriosus; Ao, Aorta; PT, pulmonary trunk; Asterisks in A, B, M and N depict the AP septal mesenchyme."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T19635","span":{"begin":10,"end":19},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T19636","span":{"begin":24,"end":28},"obj":"PR_EXT:000000047"},{"id":"T19637","span":{"begin":33,"end":37},"obj":"PR_EXT:000000067"},{"id":"T19638","span":{"begin":38,"end":46},"obj":"GO:0065007"},{"id":"T19639","span":{"begin":68,"end":75},"obj":"UBERON:0000947"},{"id":"T19640","span":{"begin":76,"end":85},"obj":"UBERON:0002048"},{"id":"T19641","span":{"begin":183,"end":187},"obj":"PR_EXT:000000047"},{"id":"T19642","span":{"begin":188,"end":192},"obj":"PR_EXT:000017435"},{"id":"T19643","span":{"begin":197,"end":203},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T19644","span":{"begin":214,"end":218},"obj":"PR_EXT:000000067"},{"id":"T19645","span":{"begin":219,"end":223},"obj":"PR_EXT:000017435"},{"id":"T19646","span":{"begin":228,"end":234},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T19647","span":{"begin":285,"end":286},"obj":"CHEBI:51686"},{"id":"T19648","span":{"begin":287,"end":288},"obj":"CHEBI_EXT:eosin"},{"id":"T19649","span":{"begin":346,"end":350},"obj":"PR_EXT:000003675"},{"id":"T19650","span":{"begin":363,"end":378},"obj":"GO_EXT:0004565"},{"id":"T19651","span":{"begin":409,"end":410},"obj":"UBERON:0003123"},{"id":"T19652","span":{"begin":416,"end":423},"obj":"UBERON:0003123"},{"id":"T19653","span":{"begin":425,"end":427},"obj":"UBERON:0005432"},{"id":"T19654","span":{"begin":429,"end":439},"obj":"UBERON:0005432"},{"id":"T19655","span":{"begin":441,"end":443},"obj":"UBERON:0002061"},{"id":"T19656","span":{"begin":445,"end":463},"obj":"UBERON:0002061"},{"id":"T19657","span":{"begin":465,"end":467},"obj":"UBERON:0000947"},{"id":"T19658","span":{"begin":469,"end":474},"obj":"UBERON:0000947"},{"id":"T19659","span":{"begin":476,"end":478},"obj":"UBERON:0002333"},{"id":"T19660","span":{"begin":480,"end":495},"obj":"UBERON:0002333"},{"id":"T19661","span":{"begin":535,"end":544},"obj":"UBERON:0006207"},{"id":"T19662","span":{"begin":545,"end":555},"obj":"UBERON:0003104"}],"text":"Figure 6 Signaling via ALK5 and ALK2 controls different aspects of aortico-pulmonary septation. Frontal sections from distal (top row) to proximal (bottom row) of the control (A-F), Alk5/Wnt1-Cre mutant (G-L) and Alk2/Wnt1-Cre mutant (M-R) samples (E11.5). A, C, E, G, I, K, M, O, Q, H\u0026E staining; B, D, F, H, J, L, N, P, R, double staining for αSMA (brown) and β-galactosidase (green; R26R reporter assay). 6, the 6th PAA; AS, aortic sac; TA, truncus arteriosus; Ao, Aorta; PT, pulmonary trunk; Asterisks in A, B, M and N depict the AP septal mesenchyme."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T19612","span":{"begin":24,"end":28},"obj":"PR:000000047"},{"id":"T19613","span":{"begin":33,"end":37},"obj":"PR:000000067"},{"id":"T19614","span":{"begin":38,"end":46},"obj":"GO:0065007"},{"id":"T19615","span":{"begin":68,"end":75},"obj":"UBERON:0000947"},{"id":"T19616","span":{"begin":76,"end":85},"obj":"UBERON:0002048"},{"id":"T19617","span":{"begin":183,"end":187},"obj":"PR:000000047"},{"id":"T19618","span":{"begin":188,"end":192},"obj":"PR:000017435"},{"id":"T19619","span":{"begin":214,"end":218},"obj":"PR:000000067"},{"id":"T19620","span":{"begin":219,"end":223},"obj":"PR:000017435"},{"id":"T19621","span":{"begin":285,"end":286},"obj":"CHEBI:51686"},{"id":"T19622","span":{"begin":346,"end":350},"obj":"PR:000003675"},{"id":"T19623","span":{"begin":409,"end":410},"obj":"UBERON:0003123"},{"id":"T19624","span":{"begin":416,"end":423},"obj":"UBERON:0003123"},{"id":"T19625","span":{"begin":425,"end":427},"obj":"UBERON:0005432"},{"id":"T19626","span":{"begin":429,"end":439},"obj":"UBERON:0005432"},{"id":"T19627","span":{"begin":441,"end":443},"obj":"UBERON:0002061"},{"id":"T19628","span":{"begin":445,"end":463},"obj":"UBERON:0002061"},{"id":"T19629","span":{"begin":465,"end":467},"obj":"UBERON:0000947"},{"id":"T19630","span":{"begin":469,"end":474},"obj":"UBERON:0000947"},{"id":"T19631","span":{"begin":476,"end":478},"obj":"UBERON:0002333"},{"id":"T19632","span":{"begin":480,"end":495},"obj":"UBERON:0002333"},{"id":"T19633","span":{"begin":535,"end":544},"obj":"UBERON:0006207"},{"id":"T19634","span":{"begin":545,"end":555},"obj":"UBERON:0003104"}],"text":"Figure 6 Signaling via ALK5 and ALK2 controls different aspects of aortico-pulmonary septation. Frontal sections from distal (top row) to proximal (bottom row) of the control (A-F), Alk5/Wnt1-Cre mutant (G-L) and Alk2/Wnt1-Cre mutant (M-R) samples (E11.5). A, C, E, G, I, K, M, O, Q, H\u0026E staining; B, D, F, H, J, L, N, P, R, double staining for αSMA (brown) and β-galactosidase (green; R26R reporter assay). 6, the 6th PAA; AS, aortic sac; TA, truncus arteriosus; Ao, Aorta; PT, pulmonary trunk; Asterisks in A, B, M and N depict the AP septal mesenchyme."}