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Id Subject Object Predicate Lexical cue
T8396 0-9 NN denotes Septation
T8397 37-43 VBZ denotes begins
T8398 10-12 IN denotes of
T8399 13-16 DT denotes the
T8400 31-36 NN denotes lumen
T8401 17-24 NN denotes outflow
T8402 25-30 NN denotes tract
T8403 44-46 IN denotes in
T8404 47-48 DT denotes a
T8405 67-76 NN denotes direction
T8406 49-56 JJ denotes cranial
T8407 56-57 HYPH denotes -
T8408 57-59 IN denotes to
T8409 59-60 HYPH denotes -
T8410 60-66 JJ denotes caudal
T8411 76-78 , denotes ,
T8412 78-86 VBG denotes starting
T8413 87-95 RB denotes distally
T8414 96-98 IN denotes in
T8415 99-102 DT denotes the
T8416 110-113 NN denotes sac
T8417 103-109 JJ denotes aortic
T8418 114-117 CC denotes and
T8419 118-128 VBG denotes proceeding
T8420 129-135 IN denotes toward
T8421 136-139 DT denotes the
T8422 140-145 NN denotes heart
T8423 146-147 -LRB- denotes [
T8424 147-149 CD denotes 24
T8425 149-150 -RRB- denotes ]
T8426 150-151 . denotes .
T8427 151-284 sentence denotes Initially, the condensed mesenchyme derived from the NC forms in the base of the aortic sac between the origins of 4th and 6th PAAs.
T8428 152-161 RB denotes Initially
T8429 208-213 VBZ denotes forms
T8430 161-163 , denotes ,
T8431 163-166 DT denotes the
T8432 177-187 NN denotes mesenchyme
T8433 167-176 VBN denotes condensed
T8434 188-195 VBN denotes derived
T8435 196-200 IN denotes from
T8436 201-204 DT denotes the
T8437 205-207 NN denotes NC
T8438 214-216 IN denotes in
T8439 217-220 DT denotes the
T8440 221-225 NN denotes base
T8441 226-228 IN denotes of
T8442 229-232 DT denotes the
T8443 240-243 NN denotes sac
T8444 233-239 JJ denotes aortic
T8445 244-251 IN denotes between
T8446 252-255 DT denotes the
T8447 256-263 NNS denotes origins
T8448 264-266 IN denotes of
T8449 267-270 JJ denotes 4th
T8450 279-283 NNS denotes PAAs
T8451 271-274 CC denotes and
T8452 275-278 JJ denotes 6th
T8453 283-284 . denotes .
T8454 284-468 sentence denotes Subsequently, two prongs of the developing aortico-pulmonary (AP) septum extend into the truncal cushions and the aortico-pulmonary septation complex crosses the aortic sac cranially.
T8455 285-297 RB denotes Subsequently
T8456 358-364 VBP denotes extend
T8457 297-299 , denotes ,
T8458 299-302 CD denotes two
T8459 303-309 NNS denotes prongs
T8460 310-312 IN denotes of
T8461 313-316 DT denotes the
T8462 351-357 NN denotes septum
T8463 317-327 VBG denotes developing
T8464 328-335 JJ denotes aortico
T8465 336-345 JJ denotes pulmonary
T8466 335-336 HYPH denotes -
T8467 346-347 -LRB- denotes (
T8468 347-349 NN denotes AP
T8469 349-350 -RRB- denotes )
T8470 365-369 IN denotes into
T8471 370-373 DT denotes the
T8472 382-390 NNS denotes cushions
T8473 374-381 JJ denotes truncal
T8474 391-394 CC denotes and
T8475 395-398 DT denotes the
T8476 427-434 NN denotes complex
T8477 399-406 JJ denotes aortico
T8478 407-416 JJ denotes pulmonary
T8479 406-407 HYPH denotes -
T8480 417-426 NN denotes septation
T8481 435-442 VBZ denotes crosses
T8482 443-446 DT denotes the
T8483 454-457 NN denotes sac
T8484 447-453 JJ denotes aortic
T8485 458-467 RB denotes cranially
T8486 467-468 . denotes .
T8487 468-708 sentence denotes In ink-injected control embryos at E11.5, a characteristic conotruncal transition separating the truncus and conus could be seen as a twisted configuration, resulting from a change in orientation of the truncal and conal cushions (Fig. 5).
T8488 469-471 IN denotes In
T8489 593-597 VBN denotes seen
T8490 472-475 NN denotes ink
T8491 476-484 VBN denotes injected
T8492 475-476 HYPH denotes -
T8493 493-500 NNS denotes embryos
T8494 485-492 NN denotes control
T8495 501-503 IN denotes at
T8496 504-509 NN denotes E11.5
T8497 509-511 , denotes ,
T8498 511-512 DT denotes a
T8499 540-550 NN denotes transition
T8500 513-527 JJ denotes characteristic
T8501 528-539 JJ denotes conotruncal
T8502 551-561 VBG denotes separating
T8503 562-565 DT denotes the
T8504 566-573 NN denotes truncus
T8505 574-577 CC denotes and
T8506 578-583 NN denotes conus
T8507 584-589 MD denotes could
T8508 590-592 VB denotes be
T8509 598-600 IN denotes as
T8510 601-602 DT denotes a
T8511 611-624 NN denotes configuration
T8512 603-610 VBN denotes twisted
T8513 624-626 , denotes ,
T8514 626-635 VBG denotes resulting
T8515 636-640 IN denotes from
T8516 641-642 DT denotes a
T8517 643-649 NN denotes change
T8518 650-652 IN denotes in
T8519 653-664 NN denotes orientation
T8520 665-667 IN denotes of
T8521 668-671 DT denotes the
T8522 690-698 NNS denotes cushions
T8523 672-679 JJ denotes truncal
T8524 680-683 CC denotes and
T8525 684-689 JJ denotes conal
T8526 699-700 -LRB- denotes (
T8527 700-704 NN denotes Fig.
T8528 705-706 CD denotes 5
T8529 706-707 -RRB- denotes )
T8530 707-708 . denotes .
T8531 708-865 sentence denotes In contrast, in Alk5/Wnt1-Cre mutants the outflow tract appeared unusually straight, failing to demonstrate the distinct conotruncal transition (Fig. 5B,D).
T8532 709-711 IN denotes In
T8533 765-773 VBD denotes appeared
T8534 712-720 NN denotes contrast
T8535 720-722 , denotes ,
T8536 722-724 IN denotes in
T8537 725-729 NN denotes Alk5
T8538 735-738 NN denotes Cre
T8539 729-730 HYPH denotes /
T8540 730-734 NN denotes Wnt1
T8541 734-735 HYPH denotes -
T8542 739-746 NNS denotes mutants
T8543 747-750 DT denotes the
T8544 759-764 NN denotes tract
T8545 751-758 NN denotes outflow
T8546 774-783 RB denotes unusually
T8547 784-792 JJ denotes straight
T8548 792-794 , denotes ,
T8549 794-801 VBG denotes failing
T8550 802-804 TO denotes to
T8551 805-816 VB denotes demonstrate
T8552 817-820 DT denotes the
T8553 842-852 NN denotes transition
T8554 821-829 JJ denotes distinct
T8555 830-841 JJ denotes conotruncal
T8556 853-854 -LRB- denotes (
T8557 862-863 NN denotes D
T8558 854-858 NN denotes Fig.
T8559 859-861 NN denotes 5B
T8560 861-862 , denotes ,
T8561 863-864 -RRB- denotes )
T8562 864-865 . denotes .
T8563 865-948 sentence denotes This assay also clearly showed a dramatic reduction in the size of the aortic sac.
T8564 866-870 DT denotes This
T8565 871-876 NN denotes assay
T8566 890-896 VBD denotes showed
T8567 877-881 RB denotes also
T8568 882-889 RB denotes clearly
T8569 897-898 DT denotes a
T8570 908-917 NN denotes reduction
T8571 899-907 JJ denotes dramatic
T8572 918-920 IN denotes in
T8573 921-924 DT denotes the
T8574 925-929 NN denotes size
T8575 930-932 IN denotes of
T8576 933-936 DT denotes the
T8577 944-947 NN denotes sac
T8578 937-943 JJ denotes aortic
T8579 947-948 . denotes .
T8580 948-1279 sentence denotes Histological analysis of control samples displayed the characteristic rotation of the aortic sac and truncal OFT at the level where the AP septation takes place and verified the presence of the distinctive condensed AP-septal mesenchyme, which gradually divided the OFT to the aorta and the pulmonary trunk (asterisks in Fig. 6A).
T8581 949-961 JJ denotes Histological
T8582 962-970 NN denotes analysis
T8583 990-999 VBD denotes displayed
T8584 971-973 IN denotes of
T8585 974-981 NN denotes control
T8586 982-989 NNS denotes samples
T8587 1000-1003 DT denotes the
T8588 1019-1027 NN denotes rotation
T8589 1004-1018 JJ denotes characteristic
T8590 1028-1030 IN denotes of
T8591 1031-1034 DT denotes the
T8592 1042-1045 NN denotes sac
T8593 1035-1041 JJ denotes aortic
T8594 1046-1049 CC denotes and
T8595 1050-1057 JJ denotes truncal
T8596 1058-1061 NN denotes OFT
T8597 1062-1064 IN denotes at
T8598 1065-1068 DT denotes the
T8599 1069-1074 NN denotes level
T8600 1075-1080 WRB denotes where
T8601 1098-1103 VBZ denotes takes
T8602 1081-1084 DT denotes the
T8603 1088-1097 NN denotes septation
T8604 1085-1087 NN denotes AP
T8605 1104-1109 NN denotes place
T8606 1110-1113 CC denotes and
T8607 1114-1122 VBD denotes verified
T8608 1123-1126 DT denotes the
T8609 1127-1135 NN denotes presence
T8610 1136-1138 IN denotes of
T8611 1139-1142 DT denotes the
T8612 1175-1185 NN denotes mesenchyme
T8613 1143-1154 JJ denotes distinctive
T8614 1155-1164 VBN denotes condensed
T8615 1165-1167 NN denotes AP
T8616 1167-1168 HYPH denotes -
T8617 1168-1174 JJ denotes septal
T8618 1185-1187 , denotes ,
T8619 1187-1192 WDT denotes which
T8620 1203-1210 VBD denotes divided
T8621 1193-1202 RB denotes gradually
T8622 1211-1214 DT denotes the
T8623 1215-1218 NN denotes OFT
T8624 1219-1221 IN denotes to
T8625 1222-1225 DT denotes the
T8626 1226-1231 NN denotes aorta
T8627 1232-1235 CC denotes and
T8628 1236-1239 DT denotes the
T8629 1250-1255 NN denotes trunk
T8630 1240-1249 JJ denotes pulmonary
T8631 1256-1257 -LRB- denotes (
T8632 1257-1266 NNS denotes asterisks
T8633 1267-1269 IN denotes in
T8634 1270-1274 NN denotes Fig.
T8635 1275-1277 NN denotes 6A
T8636 1277-1278 -RRB- denotes )
T8637 1278-1279 . denotes .
T8638 1279-1431 sentence denotes R26R lineage tracing showed that this tissue is derived from the NC, while immunostaining for α-SMA showed differentiation into smooth muscle (Fig 6B).
T8639 1280-1284 NN denotes R26R
T8640 1293-1300 NN denotes tracing
T8641 1285-1292 NN denotes lineage
T8642 1301-1307 VBD denotes showed
T8643 1308-1312 IN denotes that
T8644 1328-1335 VBN denotes derived
T8645 1313-1317 DT denotes this
T8646 1318-1324 NN denotes tissue
T8647 1325-1327 VBZ denotes is
T8648 1336-1340 IN denotes from
T8649 1341-1344 DT denotes the
T8650 1345-1347 NN denotes NC
T8651 1347-1349 , denotes ,
T8652 1349-1354 IN denotes while
T8653 1380-1386 VBD denotes showed
T8654 1355-1369 NN denotes immunostaining
T8655 1370-1373 IN denotes for
T8656 1374-1375 NN denotes α
T8657 1376-1379 NN denotes SMA
T8658 1375-1376 HYPH denotes -
T8659 1387-1402 NN denotes differentiation
T8660 1403-1407 IN denotes into
T8661 1408-1414 JJ denotes smooth
T8662 1415-1421 NN denotes muscle
T8663 1422-1423 -LRB- denotes (
T8664 1427-1429 NN denotes 6B
T8665 1423-1426 NN denotes Fig
T8666 1429-1430 -RRB- denotes )
T8667 1430-1431 . denotes .
T8668 1431-1615 sentence denotes In Alk5/Wnt1-Cre mutants the characteristic rotation of the aortic sac and truncal OFT fails to take place (Fig. 6G–L), and a properly formed AP-septum was not detectable (Fig. 6G,H).
T8669 1432-1434 IN denotes In
T8670 1519-1524 VBZ denotes fails
T8671 1435-1439 NN denotes Alk5
T8672 1445-1448 NN denotes Cre
T8673 1439-1440 HYPH denotes /
T8674 1440-1444 NN denotes Wnt1
T8675 1444-1445 HYPH denotes -
T8676 1449-1456 NNS denotes mutants
T8677 1457-1460 DT denotes the
T8678 1476-1484 NN denotes rotation
T8679 1461-1475 JJ denotes characteristic
T8680 1485-1487 IN denotes of
T8681 1488-1491 DT denotes the
T8682 1499-1502 NN denotes sac
T8683 1492-1498 JJ denotes aortic
T8684 1503-1506 CC denotes and
T8685 1507-1514 JJ denotes truncal
T8686 1515-1518 NN denotes OFT
T8687 1525-1527 TO denotes to
T8688 1528-1532 VB denotes take
T8689 1533-1538 NN denotes place
T8690 1539-1540 -LRB- denotes (
T8691 1545-1547 NN denotes 6G
T8692 1540-1544 NN denotes Fig.
T8693 1547-1548 SYM denotes –
T8694 1548-1549 NN denotes L
T8695 1549-1550 -RRB- denotes )
T8696 1550-1552 , denotes ,
T8697 1552-1555 CC denotes and
T8698 1556-1557 DT denotes a
T8699 1577-1583 NN denotes septum
T8700 1558-1566 RB denotes properly
T8701 1567-1573 VBN denotes formed
T8702 1574-1576 NN denotes AP
T8703 1576-1577 HYPH denotes -
T8704 1584-1587 VBD denotes was
T8705 1588-1591 RB denotes not
T8706 1592-1602 JJ denotes detectable
T8707 1603-1604 -LRB- denotes (
T8708 1612-1613 NN denotes H
T8709 1604-1608 NN denotes Fig.
T8710 1609-1611 NN denotes 6G
T8711 1611-1612 , denotes ,
T8712 1613-1614 -RRB- denotes )
T8713 1614-1615 . denotes .
T8714 1615-1723 sentence denotes R26R lineage tracing demonstrated that the defects were not due to failure of NCCs to reach the OFT region.
T8715 1616-1620 NN denotes R26R
T8716 1629-1636 NN denotes tracing
T8717 1621-1628 NN denotes lineage
T8718 1637-1649 VBD denotes demonstrated
T8719 1650-1654 IN denotes that
T8720 1667-1671 VBD denotes were
T8721 1655-1658 DT denotes the
T8722 1659-1666 NNS denotes defects
T8723 1672-1675 RB denotes not
T8724 1676-1679 IN denotes due
T8725 1680-1682 IN denotes to
T8726 1683-1690 NN denotes failure
T8727 1691-1693 IN denotes of
T8728 1694-1698 NNS denotes NCCs
T8729 1699-1701 TO denotes to
T8730 1702-1707 VB denotes reach
T8731 1708-1711 DT denotes the
T8732 1716-1722 NN denotes region
T8733 1712-1715 NN denotes OFT
T8734 1722-1723 . denotes .
T8735 1723-1881 sentence denotes NC-derived cells around the abnomally bifurcated aortic sac, the abnormally large sixth PAAs and the truncus demonstrated strong αSMA staining (Fig. 6H,J,L).
T8736 1724-1726 NN denotes NC
T8737 1727-1734 VBN denotes derived
T8738 1726-1727 HYPH denotes -
T8739 1735-1740 NNS denotes cells
T8740 1833-1845 VBD denotes demonstrated
T8741 1741-1747 IN denotes around
T8742 1748-1751 DT denotes the
T8743 1780-1783 NN denotes sac
T8744 1752-1761 RB denotes abnomally
T8745 1762-1772 VBN denotes bifurcated
T8746 1773-1779 JJ denotes aortic
T8747 1783-1785 , denotes ,
T8748 1785-1788 DT denotes the
T8749 1812-1816 NNS denotes PAAs
T8750 1789-1799 RB denotes abnormally
T8751 1800-1805 JJ denotes large
T8752 1806-1811 JJ denotes sixth
T8753 1817-1820 CC denotes and
T8754 1821-1824 DT denotes the
T8755 1825-1832 NN denotes truncus
T8756 1846-1852 JJ denotes strong
T8757 1858-1866 NN denotes staining
T8758 1853-1857 NN denotes αSMA
T8759 1867-1868 -LRB- denotes (
T8760 1878-1879 NN denotes L
T8761 1868-1872 NN denotes Fig.
T8762 1873-1875 NN denotes 6H
T8763 1875-1876 , denotes ,
T8764 1876-1877 NN denotes J
T8765 1877-1878 , denotes ,
T8766 1879-1880 -RRB- denotes )
T8767 1880-1881 . denotes .
T8768 1881-1994 sentence denotes Recently, we showed that the NC-specific mutants of the related type I receptor, Alk2, display PTA as well [12].
T8769 1882-1890 RB denotes Recently
T8770 1895-1901 VBD denotes showed
T8771 1890-1892 , denotes ,
T8772 1892-1894 PRP denotes we
T8773 1902-1906 IN denotes that
T8774 1969-1976 VBP denotes display
T8775 1907-1910 DT denotes the
T8776 1923-1930 NNS denotes mutants
T8777 1911-1913 NN denotes NC
T8778 1914-1922 JJ denotes specific
T8779 1913-1914 HYPH denotes -
T8780 1931-1933 IN denotes of
T8781 1934-1937 DT denotes the
T8782 1953-1961 NN denotes receptor
T8783 1938-1945 VBN denotes related
T8784 1946-1950 NN denotes type
T8785 1951-1952 CD denotes I
T8786 1961-1963 , denotes ,
T8787 1963-1967 NN denotes Alk2
T8788 1967-1969 , denotes ,
T8789 1977-1980 NN denotes PTA
T8790 1981-1983 RB denotes as
T8791 1984-1988 RB denotes well
T8792 1989-1990 -LRB- denotes [
T8793 1990-1992 CD denotes 12
T8794 1992-1993 -RRB- denotes ]
T8795 1993-1994 . denotes .
T8796 1994-2129 sentence denotes In Alk2/Wnt1-Cre mutants, the rotation of the aortic sac and truncal OFT failed to occur (Fig. 6M–R) as seen in Alk5/Wnt1-Cre mutants.
T8797 1995-1997 IN denotes In
T8798 2068-2074 VBD denotes failed
T8799 1998-2002 NN denotes Alk2
T8800 2008-2011 NN denotes Cre
T8801 2002-2003 HYPH denotes /
T8802 2003-2007 NN denotes Wnt1
T8803 2007-2008 HYPH denotes -
T8804 2012-2019 NNS denotes mutants
T8805 2019-2021 , denotes ,
T8806 2021-2024 DT denotes the
T8807 2025-2033 NN denotes rotation
T8808 2034-2036 IN denotes of
T8809 2037-2040 DT denotes the
T8810 2048-2051 NN denotes sac
T8811 2041-2047 JJ denotes aortic
T8812 2052-2055 CC denotes and
T8813 2056-2063 JJ denotes truncal
T8814 2064-2067 NN denotes OFT
T8815 2075-2077 TO denotes to
T8816 2078-2083 VB denotes occur
T8817 2084-2085 -LRB- denotes (
T8818 2090-2092 NN denotes 6M
T8819 2085-2089 NN denotes Fig.
T8820 2092-2093 SYM denotes –
T8821 2093-2094 NN denotes R
T8822 2094-2095 -RRB- denotes )
T8823 2096-2098 IN denotes as
T8824 2099-2103 VBN denotes seen
T8825 2104-2106 IN denotes in
T8826 2107-2111 NN denotes Alk5
T8827 2117-2120 NN denotes Cre
T8828 2111-2112 HYPH denotes /
T8829 2112-2116 NN denotes Wnt1
T8830 2116-2117 HYPH denotes -
T8831 2121-2128 NNS denotes mutants
T8832 2128-2129 . denotes .
T8833 2129-2455 sentence denotes However, in Alk2 mutants the 6th pair of the PAAs was grossly hypoplastic, and while the Alk2/Wnt1-Cre mutants displayed a noticeable amount of septal tissue between the 4th and 6th PAAs (Fig. 6M,N), the condensed septal mesenchyme lacking Alk2 failed to extend the prongs into the truncal cushions and to form the AP septum.
T8834 2130-2137 RB denotes However
T8835 2180-2183 VBD denotes was
T8836 2137-2139 , denotes ,
T8837 2139-2141 IN denotes in
T8838 2142-2146 NN denotes Alk2
T8839 2147-2154 NNS denotes mutants
T8840 2155-2158 DT denotes the
T8841 2163-2167 NN denotes pair
T8842 2159-2162 JJ denotes 6th
T8843 2168-2170 IN denotes of
T8844 2171-2174 DT denotes the
T8845 2175-2179 NNS denotes PAAs
T8846 2184-2191 RB denotes grossly
T8847 2192-2203 JJ denotes hypoplastic
T8848 2203-2205 , denotes ,
T8849 2205-2208 CC denotes and
T8850 2209-2214 IN denotes while
T8851 2241-2250 VBD denotes displayed
T8852 2215-2218 DT denotes the
T8853 2233-2240 NNS denotes mutants
T8854 2219-2223 NN denotes Alk2
T8855 2229-2232 NN denotes Cre
T8856 2223-2224 HYPH denotes /
T8857 2224-2228 NN denotes Wnt1
T8858 2228-2229 HYPH denotes -
T8859 2375-2381 VBD denotes failed
T8860 2251-2252 DT denotes a
T8861 2264-2270 NN denotes amount
T8862 2253-2263 JJ denotes noticeable
T8863 2271-2273 IN denotes of
T8864 2274-2280 JJ denotes septal
T8865 2281-2287 NN denotes tissue
T8866 2288-2295 IN denotes between
T8867 2296-2299 DT denotes the
T8868 2312-2316 NNS denotes PAAs
T8869 2300-2303 JJ denotes 4th
T8870 2304-2307 CC denotes and
T8871 2308-2311 JJ denotes 6th
T8872 2317-2318 -LRB- denotes (
T8873 2326-2327 NN denotes N
T8874 2318-2322 NN denotes Fig.
T8875 2323-2325 NN denotes 6M
T8876 2325-2326 , denotes ,
T8877 2327-2328 -RRB- denotes )
T8878 2328-2330 , denotes ,
T8879 2330-2333 DT denotes the
T8880 2351-2361 NN denotes mesenchyme
T8881 2334-2343 VBN denotes condensed
T8882 2344-2350 JJ denotes septal
T8883 2362-2369 VBG denotes lacking
T8884 2370-2374 NN denotes Alk2
T8885 2382-2384 TO denotes to
T8886 2385-2391 VB denotes extend
T8887 2392-2395 DT denotes the
T8888 2396-2402 NNS denotes prongs
T8889 2403-2407 IN denotes into
T8890 2408-2411 DT denotes the
T8891 2420-2428 NNS denotes cushions
T8892 2412-2419 JJ denotes truncal
T8893 2429-2432 CC denotes and
T8894 2433-2435 TO denotes to
T8895 2436-2440 VB denotes form
T8896 2441-2444 DT denotes the
T8897 2448-2454 NN denotes septum
T8898 2445-2447 NN denotes AP
T8899 2454-2455 . denotes .
T8900 2455-2586 sentence denotes Concurrently, the 6th PAAs were losing their patency, which may have further contributed to the failed AP septation (Fig. 6M,O,Q).
T8901 2456-2468 RB denotes Concurrently
T8902 2488-2494 VBG denotes losing
T8903 2468-2470 , denotes ,
T8904 2470-2473 DT denotes the
T8905 2478-2482 NNS denotes PAAs
T8906 2474-2477 JJ denotes 6th
T8907 2483-2487 VBD denotes were
T8908 2495-2500 PRP$ denotes their
T8909 2501-2508 NN denotes patency
T8910 2508-2510 , denotes ,
T8911 2510-2515 WDT denotes which
T8912 2533-2544 VBN denotes contributed
T8913 2516-2519 MD denotes may
T8914 2520-2524 VB denotes have
T8915 2525-2532 RB denotes further
T8916 2545-2547 IN denotes to
T8917 2548-2551 DT denotes the
T8918 2562-2571 NN denotes septation
T8919 2552-2558 VBN denotes failed
T8920 2559-2561 NN denotes AP
T8921 2572-2573 -LRB- denotes (
T8922 2583-2584 NN denotes Q
T8923 2573-2577 NN denotes Fig.
T8924 2578-2580 NN denotes 6M
T8925 2580-2581 , denotes ,
T8926 2581-2582 NN denotes O
T8927 2582-2583 , denotes ,
T8928 2584-2585 -RRB- denotes )
T8929 2585-2586 . denotes .
T8930 2586-2887 sentence denotes While CNCCs managed to migrate to the aortic sac and the truncal cushion level (Fig. 6N,P,R), immunostaining for αSMA appeared much weaker when compared to controls and Alk5 mutants, implying that ALK2-mediated signaling is involved in smooth muscle cell differentiation as previously suggested [12].
T8931 2587-2592 IN denotes While
T8932 2599-2606 VBD denotes managed
T8933 2593-2598 NNS denotes CNCCs
T8934 2705-2713 VBD denotes appeared
T8935 2607-2609 TO denotes to
T8936 2610-2617 VB denotes migrate
T8937 2618-2620 IN denotes to
T8938 2621-2624 DT denotes the
T8939 2632-2635 NN denotes sac
T8940 2625-2631 JJ denotes aortic
T8941 2636-2639 CC denotes and
T8942 2640-2643 DT denotes the
T8943 2660-2665 NN denotes level
T8944 2644-2651 JJ denotes truncal
T8945 2652-2659 NN denotes cushion
T8946 2666-2667 -LRB- denotes (
T8947 2677-2678 NN denotes R
T8948 2667-2671 NN denotes Fig.
T8949 2672-2674 NN denotes 6N
T8950 2674-2675 , denotes ,
T8951 2675-2676 NN denotes P
T8952 2676-2677 , denotes ,
T8953 2678-2679 -RRB- denotes )
T8954 2679-2681 , denotes ,
T8955 2681-2695 NN denotes immunostaining
T8956 2696-2699 IN denotes for
T8957 2700-2704 NN denotes αSMA
T8958 2714-2718 RB denotes much
T8959 2719-2725 JJR denotes weaker
T8960 2726-2730 WRB denotes when
T8961 2731-2739 VBN denotes compared
T8962 2740-2742 IN denotes to
T8963 2743-2751 NNS denotes controls
T8964 2752-2755 CC denotes and
T8965 2756-2760 NN denotes Alk5
T8966 2761-2768 NNS denotes mutants
T8967 2768-2770 , denotes ,
T8968 2770-2778 VBG denotes implying
T8969 2779-2783 IN denotes that
T8970 2811-2819 VBN denotes involved
T8971 2784-2788 NN denotes ALK2
T8972 2789-2797 VBN denotes mediated
T8973 2788-2789 HYPH denotes -
T8974 2798-2807 NN denotes signaling
T8975 2808-2810 VBZ denotes is
T8976 2820-2822 IN denotes in
T8977 2823-2829 JJ denotes smooth
T8978 2830-2836 NN denotes muscle
T8979 2842-2857 NN denotes differentiation
T8980 2837-2841 NN denotes cell
T8981 2858-2860 IN denotes as
T8982 2872-2881 VBN denotes suggested
T8983 2861-2871 RB denotes previously
T8984 2882-2883 -LRB- denotes [
T8985 2883-2885 CD denotes 12
T8986 2885-2886 -RRB- denotes ]
T8987 2886-2887 . denotes .
T8988 2887-3132 sentence denotes To conclude, while both Alk2 and Alk5 mutants demonstrate a failure in both the rotation of the aortic sac and the truncal OFT, and in the formation of the AP septum, the pathogenetic mechanisms behind these defects appear remarkably different.
T8989 2888-2890 TO denotes To
T8990 2891-2899 VB denotes conclude
T8991 3104-3110 VBP denotes appear
T8992 2899-2901 , denotes ,
T8993 2901-2906 IN denotes while
T8994 2934-2945 VBP denotes demonstrate
T8995 2907-2911 CC denotes both
T8996 2912-2916 NN denotes Alk2
T8997 2926-2933 NNS denotes mutants
T8998 2917-2920 CC denotes and
T8999 2921-2925 NN denotes Alk5
T9000 2946-2947 DT denotes a
T9001 2948-2955 NN denotes failure
T9002 2956-2958 IN denotes in
T9003 2959-2963 CC denotes both
T9004 2968-2976 NN denotes rotation
T9005 2964-2967 DT denotes the
T9006 2977-2979 IN denotes of
T9007 2980-2983 DT denotes the
T9008 2991-2994 NN denotes sac
T9009 2984-2990 JJ denotes aortic
T9010 2995-2998 CC denotes and
T9011 2999-3002 DT denotes the
T9012 3011-3014 NN denotes OFT
T9013 3003-3010 JJ denotes truncal
T9014 3014-3016 , denotes ,
T9015 3016-3019 CC denotes and
T9016 3020-3022 IN denotes in
T9017 3023-3026 DT denotes the
T9018 3027-3036 NN denotes formation
T9019 3037-3039 IN denotes of
T9020 3040-3043 DT denotes the
T9021 3047-3053 NN denotes septum
T9022 3044-3046 NN denotes AP
T9023 3053-3055 , denotes ,
T9024 3055-3058 DT denotes the
T9025 3072-3082 NNS denotes mechanisms
T9026 3059-3071 JJ denotes pathogenetic
T9027 3083-3089 IN denotes behind
T9028 3090-3095 DT denotes these
T9029 3096-3103 NNS denotes defects
T9030 3111-3121 RB denotes remarkably
T9031 3122-3131 JJ denotes different
T9032 3131-3132 . denotes .
R2195 T8396 T8397 nsubj Septation,begins
R2196 T8398 T8396 prep of,Septation
R2197 T8399 T8400 det the,lumen
R2198 T8400 T8398 pobj lumen,of
R2199 T8401 T8402 compound outflow,tract
R2200 T8402 T8400 compound tract,lumen
R2201 T8403 T8397 prep in,begins
R2202 T8404 T8405 det a,direction
R2203 T8405 T8403 pobj direction,in
R2204 T8406 T8405 amod cranial,direction
R2205 T8407 T8406 punct -,cranial
R2206 T8408 T8406 prep to,cranial
R2207 T8409 T8408 punct -,to
R2208 T8410 T8408 amod caudal,to
R2209 T8411 T8397 punct ", ",begins
R2210 T8412 T8397 advcl starting,begins
R2211 T8413 T8412 advmod distally,starting
R2212 T8414 T8412 prep in,starting
R2213 T8415 T8416 det the,sac
R2214 T8416 T8414 pobj sac,in
R2215 T8417 T8416 amod aortic,sac
R2216 T8418 T8412 cc and,starting
R2217 T8419 T8412 conj proceeding,starting
R2218 T8420 T8419 prep toward,proceeding
R2219 T8421 T8422 det the,heart
R2220 T8422 T8420 pobj heart,toward
R2221 T8423 T8424 punct [,24
R2222 T8424 T8397 parataxis 24,begins
R2223 T8425 T8424 punct ],24
R2224 T8426 T8397 punct .,begins
R2225 T8428 T8429 advmod Initially,forms
R2226 T8430 T8429 punct ", ",forms
R2227 T8431 T8432 det the,mesenchyme
R2228 T8432 T8429 nsubj mesenchyme,forms
R2229 T8433 T8432 amod condensed,mesenchyme
R2230 T8434 T8432 acl derived,mesenchyme
R2231 T8435 T8434 prep from,derived
R2232 T8436 T8437 det the,NC
R2233 T8437 T8435 pobj NC,from
R2234 T8438 T8429 prep in,forms
R2235 T8439 T8440 det the,base
R2236 T8440 T8438 pobj base,in
R2237 T8441 T8440 prep of,base
R2238 T8442 T8443 det the,sac
R2239 T8443 T8441 pobj sac,of
R2240 T8444 T8443 amod aortic,sac
R2241 T8445 T8429 prep between,forms
R2242 T8446 T8447 det the,origins
R2243 T8447 T8445 pobj origins,between
R2244 T8448 T8447 prep of,origins
R2245 T8449 T8450 amod 4th,PAAs
R2246 T8450 T8448 pobj PAAs,of
R2247 T8451 T8449 cc and,4th
R2248 T8452 T8449 conj 6th,4th
R2249 T8453 T8429 punct .,forms
R2250 T8455 T8456 advmod Subsequently,extend
R2251 T8457 T8456 punct ", ",extend
R2252 T8458 T8459 nummod two,prongs
R2253 T8459 T8456 nsubj prongs,extend
R2254 T8460 T8459 prep of,prongs
R2255 T8461 T8462 det the,septum
R2256 T8462 T8460 pobj septum,of
R2257 T8463 T8462 amod developing,septum
R2258 T8464 T8465 amod aortico,pulmonary
R2259 T8465 T8462 amod pulmonary,septum
R2260 T8466 T8465 punct -,pulmonary
R2261 T8467 T8468 punct (,AP
R2262 T8468 T8465 parataxis AP,pulmonary
R2263 T8469 T8468 punct ),AP
R2264 T8470 T8456 prep into,extend
R2265 T8471 T8472 det the,cushions
R2266 T8472 T8470 pobj cushions,into
R2267 T8473 T8472 amod truncal,cushions
R2268 T8474 T8456 cc and,extend
R2269 T8475 T8476 det the,complex
R2270 T8476 T8481 nsubj complex,crosses
R2271 T8477 T8478 amod aortico,pulmonary
R2272 T8478 T8476 amod pulmonary,complex
R2273 T8479 T8478 punct -,pulmonary
R2274 T8480 T8476 compound septation,complex
R2275 T8481 T8456 conj crosses,extend
R2276 T8482 T8483 det the,sac
R2277 T8483 T8481 dobj sac,crosses
R2278 T8484 T8483 amod aortic,sac
R2279 T8485 T8481 advmod cranially,crosses
R2280 T8486 T8481 punct .,crosses
R2281 T8488 T8489 prep In,seen
R2282 T8490 T8491 npadvmod ink,injected
R2283 T8491 T8493 amod injected,embryos
R2284 T8492 T8491 punct -,injected
R2285 T8493 T8488 pobj embryos,In
R2286 T8494 T8493 compound control,embryos
R2287 T8495 T8489 prep at,seen
R2288 T8496 T8495 pobj E11.5,at
R2289 T8497 T8489 punct ", ",seen
R2290 T8498 T8499 det a,transition
R2291 T8499 T8489 nsubjpass transition,seen
R2292 T8500 T8499 amod characteristic,transition
R2293 T8501 T8499 amod conotruncal,transition
R2294 T8502 T8499 acl separating,transition
R2295 T8503 T8504 det the,truncus
R2296 T8504 T8502 dobj truncus,separating
R2297 T8505 T8504 cc and,truncus
R2298 T8506 T8504 conj conus,truncus
R2299 T8507 T8489 aux could,seen
R2300 T8508 T8489 auxpass be,seen
R2301 T8509 T8489 prep as,seen
R2302 T8510 T8511 det a,configuration
R2303 T8511 T8509 pobj configuration,as
R2304 T8512 T8511 amod twisted,configuration
R2305 T8513 T8511 punct ", ",configuration
R2306 T8514 T8511 acl resulting,configuration
R2307 T8515 T8514 prep from,resulting
R2308 T8516 T8517 det a,change
R2309 T8517 T8515 pobj change,from
R2310 T8518 T8517 prep in,change
R2311 T8519 T8518 pobj orientation,in
R2312 T8520 T8519 prep of,orientation
R2313 T8521 T8522 det the,cushions
R2314 T8522 T8520 pobj cushions,of
R2315 T8523 T8522 amod truncal,cushions
R2316 T8524 T8523 cc and,truncal
R2317 T8525 T8523 conj conal,truncal
R2318 T8526 T8527 punct (,Fig.
R2319 T8527 T8514 parataxis Fig.,resulting
R2320 T8528 T8527 nummod 5,Fig.
R2321 T8529 T8527 punct ),Fig.
R2322 T8530 T8489 punct .,seen
R2323 T8532 T8533 prep In,appeared
R2324 T8534 T8532 pobj contrast,In
R2325 T8535 T8533 punct ", ",appeared
R2326 T8536 T8533 prep in,appeared
R2327 T8537 T8538 compound Alk5,Cre
R2328 T8538 T8542 compound Cre,mutants
R2329 T8539 T8538 punct /,Cre
R2330 T8540 T8538 compound Wnt1,Cre
R2331 T8541 T8538 punct -,Cre
R2332 T8542 T8536 pobj mutants,in
R2333 T8543 T8544 det the,tract
R2334 T8544 T8533 nsubj tract,appeared
R2335 T8545 T8544 compound outflow,tract
R2336 T8546 T8547 advmod unusually,straight
R2337 T8547 T8533 oprd straight,appeared
R2338 T8548 T8533 punct ", ",appeared
R2339 T8549 T8533 advcl failing,appeared
R2340 T8550 T8551 aux to,demonstrate
R2341 T8551 T8549 xcomp demonstrate,failing
R2342 T8552 T8553 det the,transition
R2343 T8553 T8551 dobj transition,demonstrate
R2344 T8554 T8553 amod distinct,transition
R2345 T8555 T8553 amod conotruncal,transition
R2346 T8556 T8557 punct (,D
R2347 T8557 T8533 parataxis D,appeared
R2348 T8558 T8557 nmod Fig.,D
R2349 T8559 T8557 nmod 5B,D
R2350 T8560 T8557 punct ",",D
R2351 T8561 T8557 punct ),D
R2352 T8562 T8533 punct .,appeared
R2353 T8564 T8565 det This,assay
R2354 T8565 T8566 nsubj assay,showed
R2355 T8567 T8566 advmod also,showed
R2356 T8568 T8566 advmod clearly,showed
R2357 T8569 T8570 det a,reduction
R2358 T8570 T8566 dobj reduction,showed
R2359 T8571 T8570 amod dramatic,reduction
R2360 T8572 T8570 prep in,reduction
R2361 T8573 T8574 det the,size
R2362 T8574 T8572 pobj size,in
R2363 T8575 T8574 prep of,size
R2364 T8576 T8577 det the,sac
R2365 T8577 T8575 pobj sac,of
R2366 T8578 T8577 amod aortic,sac
R2367 T8579 T8566 punct .,showed
R2368 T8581 T8582 amod Histological,analysis
R2369 T8582 T8583 nsubj analysis,displayed
R2370 T8584 T8582 prep of,analysis
R2371 T8585 T8586 compound control,samples
R2372 T8586 T8584 pobj samples,of
R2373 T8587 T8588 det the,rotation
R2374 T8588 T8583 dobj rotation,displayed
R2375 T8589 T8588 amod characteristic,rotation
R2376 T8590 T8588 prep of,rotation
R2377 T8591 T8592 det the,sac
R2378 T8592 T8590 pobj sac,of
R2379 T8593 T8592 amod aortic,sac
R2380 T8594 T8592 cc and,sac
R2381 T8595 T8596 amod truncal,OFT
R2382 T8596 T8592 conj OFT,sac
R2383 T8597 T8583 prep at,displayed
R2384 T8598 T8599 det the,level
R2385 T8599 T8597 pobj level,at
R2386 T8600 T8601 advmod where,takes
R2387 T8601 T8599 relcl takes,level
R2388 T8602 T8603 det the,septation
R2389 T8603 T8601 nsubj septation,takes
R2390 T8604 T8603 compound AP,septation
R2391 T8605 T8601 dobj place,takes
R2392 T8606 T8583 cc and,displayed
R2393 T8607 T8583 conj verified,displayed
R2394 T8608 T8609 det the,presence
R2395 T8609 T8607 dobj presence,verified
R2396 T8610 T8609 prep of,presence
R2397 T8611 T8612 det the,mesenchyme
R2398 T8612 T8610 pobj mesenchyme,of
R2399 T8613 T8612 amod distinctive,mesenchyme
R2400 T8614 T8612 amod condensed,mesenchyme
R2401 T8615 T8612 nmod AP,mesenchyme
R2402 T8616 T8615 punct -,AP
R2403 T8617 T8615 amod septal,AP
R2404 T8618 T8612 punct ", ",mesenchyme
R2405 T8619 T8620 dep which,divided
R2406 T8620 T8612 relcl divided,mesenchyme
R2407 T8621 T8620 advmod gradually,divided
R2408 T8622 T8623 det the,OFT
R2409 T8623 T8620 dobj OFT,divided
R2410 T8624 T8620 prep to,divided
R2411 T8625 T8626 det the,aorta
R2412 T8626 T8624 pobj aorta,to
R2413 T8627 T8626 cc and,aorta
R2414 T8628 T8629 det the,trunk
R2415 T8629 T8626 conj trunk,aorta
R2416 T8630 T8629 amod pulmonary,trunk
R2417 T8631 T8632 punct (,asterisks
R2418 T8632 T8620 parataxis asterisks,divided
R2419 T8633 T8632 prep in,asterisks
R2420 T8634 T8635 compound Fig.,6A
R2421 T8635 T8633 pobj 6A,in
R2422 T8636 T8632 punct ),asterisks
R2423 T8637 T8583 punct .,displayed
R2424 T8639 T8640 compound R26R,tracing
R2425 T8640 T8642 nsubj tracing,showed
R2426 T8641 T8640 compound lineage,tracing
R2427 T8643 T8644 mark that,derived
R2428 T8644 T8642 ccomp derived,showed
R2429 T8645 T8646 det this,tissue
R2430 T8646 T8644 nsubjpass tissue,derived
R2431 T8647 T8644 auxpass is,derived
R2432 T8648 T8644 prep from,derived
R2433 T8649 T8650 det the,NC
R2434 T8650 T8648 pobj NC,from
R2435 T8651 T8644 punct ", ",derived
R2436 T8652 T8653 mark while,showed
R2437 T8653 T8644 advcl showed,derived
R2438 T8654 T8653 nsubj immunostaining,showed
R2439 T8655 T8654 prep for,immunostaining
R2440 T8656 T8657 compound α,SMA
R2441 T8657 T8655 pobj SMA,for
R2442 T8658 T8657 punct -,SMA
R2443 T8659 T8653 dobj differentiation,showed
R2444 T8660 T8659 prep into,differentiation
R2445 T8661 T8662 amod smooth,muscle
R2446 T8662 T8660 pobj muscle,into
R2447 T8663 T8664 punct (,6B
R2448 T8664 T8653 parataxis 6B,showed
R2449 T8665 T8664 compound Fig,6B
R2450 T8666 T8664 punct ),6B
R2451 T8667 T8642 punct .,showed
R2452 T8669 T8670 prep In,fails
R2453 T8671 T8672 compound Alk5,Cre
R2454 T8672 T8676 compound Cre,mutants
R2455 T8673 T8672 punct /,Cre
R2456 T8674 T8672 compound Wnt1,Cre
R2457 T8675 T8672 punct -,Cre
R2458 T8676 T8669 pobj mutants,In
R2459 T8677 T8678 det the,rotation
R2460 T8678 T8670 nsubj rotation,fails
R2461 T8679 T8678 amod characteristic,rotation
R2462 T8680 T8678 prep of,rotation
R2463 T8681 T8682 det the,sac
R2464 T8682 T8680 pobj sac,of
R2465 T8683 T8682 amod aortic,sac
R2466 T8684 T8682 cc and,sac
R2467 T8685 T8686 amod truncal,OFT
R2468 T8686 T8682 conj OFT,sac
R2469 T8687 T8688 aux to,take
R2470 T8688 T8670 xcomp take,fails
R2471 T8689 T8688 dobj place,take
R2472 T8690 T8691 punct (,6G
R2473 T8691 T8688 parataxis 6G,take
R2474 T8692 T8691 compound Fig.,6G
R2475 T8693 T8694 punct –,L
R2476 T8694 T8691 prep L,6G
R2477 T8695 T8691 punct ),6G
R2478 T8696 T8670 punct ", ",fails
R2479 T8697 T8670 cc and,fails
R2480 T8698 T8699 det a,septum
R2481 T8699 T8704 nsubj septum,was
R2482 T8700 T8701 advmod properly,formed
R2483 T8701 T8699 amod formed,septum
R2484 T8702 T8699 compound AP,septum
R2485 T8703 T8699 punct -,septum
R2486 T8704 T8670 conj was,fails
R2487 T8705 T8704 neg not,was
R2488 T8706 T8704 acomp detectable,was
R2489 T8707 T8708 punct (,H
R2490 T8708 T8704 parataxis H,was
R2491 T8709 T8708 nmod Fig.,H
R2492 T8710 T8708 nmod 6G,H
R2493 T8711 T8708 punct ",",H
R2494 T8712 T8708 punct ),H
R2495 T8713 T8670 punct .,fails
R2496 T8715 T8716 compound R26R,tracing
R2497 T8716 T8718 nsubj tracing,demonstrated
R2498 T8717 T8716 compound lineage,tracing
R2499 T8719 T8720 mark that,were
R2500 T8720 T8718 ccomp were,demonstrated
R2501 T8721 T8722 det the,defects
R2502 T8722 T8720 nsubj defects,were
R2503 T8723 T8720 neg not,were
R2504 T8724 T8720 prep due,were
R2505 T8725 T8724 pcomp to,due
R2506 T8726 T8724 pobj failure,due
R2507 T8727 T8726 prep of,failure
R2508 T8728 T8727 pobj NCCs,of
R2509 T8729 T8730 aux to,reach
R2510 T8730 T8726 acl reach,failure
R2511 T8731 T8732 det the,region
R2512 T8732 T8730 dobj region,reach
R2513 T8733 T8732 compound OFT,region
R2514 T8734 T8718 punct .,demonstrated
R2515 T8736 T8737 npadvmod NC,derived
R2516 T8737 T8739 amod derived,cells
R2517 T8738 T8737 punct -,derived
R2518 T8739 T8740 nsubj cells,demonstrated
R2519 T8741 T8739 prep around,cells
R2520 T8742 T8743 det the,sac
R2521 T8743 T8741 pobj sac,around
R2522 T8744 T8745 advmod abnomally,bifurcated
R2523 T8745 T8743 amod bifurcated,sac
R2524 T8746 T8743 amod aortic,sac
R2525 T8747 T8739 punct ", ",cells
R2526 T8748 T8749 det the,PAAs
R2527 T8749 T8739 conj PAAs,cells
R2528 T8750 T8751 advmod abnormally,large
R2529 T8751 T8749 amod large,PAAs
R2530 T8752 T8749 amod sixth,PAAs
R2531 T8753 T8749 cc and,PAAs
R2532 T8754 T8755 det the,truncus
R2533 T8755 T8749 conj truncus,PAAs
R2534 T8756 T8757 amod strong,staining
R2535 T8757 T8740 dobj staining,demonstrated
R2536 T8758 T8757 compound αSMA,staining
R2537 T8759 T8760 punct (,L
R2538 T8760 T8740 parataxis L,demonstrated
R2539 T8761 T8760 nmod Fig.,L
R2540 T8762 T8760 nmod 6H,L
R2541 T8763 T8760 punct ",",L
R2542 T8764 T8760 nmod J,L
R2543 T8765 T8760 punct ",",L
R2544 T8766 T8760 punct ),L
R2545 T8767 T8740 punct .,demonstrated
R2546 T8769 T8770 advmod Recently,showed
R2547 T8771 T8770 punct ", ",showed
R2548 T8772 T8770 nsubj we,showed
R2549 T8773 T8774 mark that,display
R2550 T8774 T8770 ccomp display,showed
R2551 T8775 T8776 det the,mutants
R2552 T8776 T8774 nsubj mutants,display
R2553 T8777 T8778 npadvmod NC,specific
R2554 T8778 T8776 amod specific,mutants
R2555 T8779 T8778 punct -,specific
R2556 T8780 T8776 prep of,mutants
R2557 T8781 T8782 det the,receptor
R2558 T8782 T8780 pobj receptor,of
R2559 T8783 T8782 amod related,receptor
R2560 T8784 T8782 nmod type,receptor
R2561 T8785 T8784 nummod I,type
R2562 T8786 T8782 punct ", ",receptor
R2563 T8787 T8782 appos Alk2,receptor
R2564 T8788 T8774 punct ", ",display
R2565 T8789 T8774 dobj PTA,display
R2566 T8790 T8791 advmod as,well
R2567 T8791 T8774 advmod well,display
R2568 T8792 T8793 punct [,12
R2569 T8793 T8774 parataxis 12,display
R2570 T8794 T8793 punct ],12
R2571 T8795 T8770 punct .,showed
R2572 T8797 T8798 prep In,failed
R2573 T8799 T8800 compound Alk2,Cre
R2574 T8800 T8804 compound Cre,mutants
R2575 T8801 T8800 punct /,Cre
R2576 T8802 T8800 compound Wnt1,Cre
R2577 T8803 T8800 punct -,Cre
R2578 T8804 T8797 pobj mutants,In
R2579 T8805 T8798 punct ", ",failed
R2580 T8806 T8807 det the,rotation
R2581 T8807 T8798 nsubj rotation,failed
R2582 T8808 T8807 prep of,rotation
R2583 T8809 T8810 det the,sac
R2584 T8810 T8808 pobj sac,of
R2585 T8811 T8810 amod aortic,sac
R2586 T8812 T8810 cc and,sac
R2587 T8813 T8814 amod truncal,OFT
R2588 T8814 T8810 conj OFT,sac
R2589 T8815 T8816 aux to,occur
R2590 T8816 T8798 xcomp occur,failed
R2591 T8817 T8818 punct (,6M
R2592 T8818 T8816 parataxis 6M,occur
R2593 T8819 T8818 compound Fig.,6M
R2594 T8820 T8821 punct –,R
R2595 T8821 T8818 prep R,6M
R2596 T8822 T8818 punct ),6M
R2597 T8823 T8824 mark as,seen
R2598 T8824 T8816 advcl seen,occur
R2599 T8825 T8824 prep in,seen
R2600 T8826 T8827 compound Alk5,Cre
R2601 T8827 T8831 compound Cre,mutants
R2602 T8828 T8827 punct /,Cre
R2603 T8829 T8827 compound Wnt1,Cre
R2604 T8830 T8827 punct -,Cre
R2605 T8831 T8825 pobj mutants,in
R2606 T8832 T8798 punct .,failed
R2607 T8834 T8835 advmod However,was
R2608 T8836 T8835 punct ", ",was
R2609 T8837 T8835 prep in,was
R2610 T8838 T8839 compound Alk2,mutants
R2611 T8839 T8837 pobj mutants,in
R2612 T8840 T8841 det the,pair
R2613 T8841 T8835 nsubj pair,was
R2614 T8842 T8841 amod 6th,pair
R2615 T8843 T8841 prep of,pair
R2616 T8844 T8845 det the,PAAs
R2617 T8845 T8843 pobj PAAs,of
R2618 T8846 T8847 advmod grossly,hypoplastic
R2619 T8847 T8835 acomp hypoplastic,was
R2620 T8848 T8835 punct ", ",was
R2621 T8849 T8835 cc and,was
R2622 T8850 T8851 mark while,displayed
R2623 T8851 T8859 advcl displayed,failed
R2624 T8852 T8853 det the,mutants
R2625 T8853 T8851 nsubj mutants,displayed
R2626 T8854 T8855 compound Alk2,Cre
R2627 T8855 T8853 compound Cre,mutants
R2628 T8856 T8855 punct /,Cre
R2629 T8857 T8855 compound Wnt1,Cre
R2630 T8858 T8855 punct -,Cre
R2631 T8859 T8835 conj failed,was
R2632 T8860 T8861 det a,amount
R2633 T8861 T8851 dobj amount,displayed
R2634 T8862 T8861 amod noticeable,amount
R2635 T8863 T8861 prep of,amount
R2636 T8864 T8865 amod septal,tissue
R2637 T8865 T8863 pobj tissue,of
R2638 T8866 T8861 prep between,amount
R2639 T8867 T8868 det the,PAAs
R2640 T8868 T8866 pobj PAAs,between
R2641 T8869 T8868 nmod 4th,PAAs
R2642 T8870 T8869 cc and,4th
R2643 T8871 T8869 conj 6th,4th
R2644 T8872 T8873 punct (,N
R2645 T8873 T8851 parataxis N,displayed
R2646 T8874 T8873 nmod Fig.,N
R2647 T8875 T8873 nmod 6M,N
R2648 T8876 T8873 punct ",",N
R2649 T8877 T8873 punct ),N
R2650 T8878 T8859 punct ", ",failed
R2651 T8879 T8880 det the,mesenchyme
R2652 T8880 T8859 nsubj mesenchyme,failed
R2653 T8881 T8880 amod condensed,mesenchyme
R2654 T8882 T8880 amod septal,mesenchyme
R2655 T8883 T8880 acl lacking,mesenchyme
R2656 T8884 T8883 dobj Alk2,lacking
R2657 T8885 T8886 aux to,extend
R2658 T8886 T8859 xcomp extend,failed
R2659 T8887 T8888 det the,prongs
R2660 T8888 T8886 dobj prongs,extend
R2661 T8889 T8886 prep into,extend
R2662 T8890 T8891 det the,cushions
R2663 T8891 T8889 pobj cushions,into
R2664 T8892 T8891 amod truncal,cushions
R2665 T8893 T8886 cc and,extend
R2666 T8894 T8895 aux to,form
R2667 T8895 T8886 conj form,extend
R2668 T8896 T8897 det the,septum
R2669 T8897 T8895 dobj septum,form
R2670 T8898 T8897 compound AP,septum
R2671 T8899 T8859 punct .,failed
R2672 T8901 T8902 advmod Concurrently,losing
R2673 T8903 T8902 punct ", ",losing
R2674 T8904 T8905 det the,PAAs
R2675 T8905 T8902 nsubj PAAs,losing
R2676 T8906 T8905 amod 6th,PAAs
R2677 T8907 T8902 aux were,losing
R2678 T8908 T8909 poss their,patency
R2679 T8909 T8902 dobj patency,losing
R2680 T8910 T8902 punct ", ",losing
R2681 T8911 T8912 dep which,contributed
R2682 T8912 T8902 advcl contributed,losing
R2683 T8913 T8912 aux may,contributed
R2684 T8914 T8912 aux have,contributed
R2685 T8915 T8912 advmod further,contributed
R2686 T8916 T8912 prep to,contributed
R2687 T8917 T8918 det the,septation
R2688 T8918 T8916 pobj septation,to
R2689 T8919 T8918 amod failed,septation
R2690 T8920 T8918 compound AP,septation
R2691 T8921 T8922 punct (,Q
R2692 T8922 T8902 parataxis Q,losing
R2693 T8923 T8922 nmod Fig.,Q
R2694 T8924 T8922 nmod 6M,Q
R2695 T8925 T8922 punct ",",Q
R2696 T8926 T8922 nmod O,Q
R2697 T8927 T8922 punct ",",Q
R2698 T8928 T8922 punct ),Q
R2699 T8929 T8902 punct .,losing
R2700 T8931 T8932 mark While,managed
R2701 T8932 T8934 advcl managed,appeared
R2702 T8933 T8932 nsubj CNCCs,managed
R2703 T8935 T8936 aux to,migrate
R2704 T8936 T8932 xcomp migrate,managed
R2705 T8937 T8936 prep to,migrate
R2706 T8938 T8939 det the,sac
R2707 T8939 T8937 pobj sac,to
R2708 T8940 T8939 amod aortic,sac
R2709 T8941 T8939 cc and,sac
R2710 T8942 T8943 det the,level
R2711 T8943 T8939 conj level,sac
R2712 T8944 T8943 amod truncal,level
R2713 T8945 T8943 compound cushion,level
R2714 T8946 T8947 punct (,R
R2715 T8947 T8936 parataxis R,migrate
R2716 T8948 T8947 nmod Fig.,R
R2717 T8949 T8947 nmod 6N,R
R2718 T8950 T8947 punct ",",R
R2719 T8951 T8947 nmod P,R
R2720 T8952 T8947 punct ",",R
R2721 T8953 T8947 punct ),R
R2722 T8954 T8934 punct ", ",appeared
R2723 T8955 T8934 nsubj immunostaining,appeared
R2724 T8956 T8955 prep for,immunostaining
R2725 T8957 T8956 pobj αSMA,for
R2726 T8958 T8959 advmod much,weaker
R2727 T8959 T8934 oprd weaker,appeared
R2728 T8960 T8961 advmod when,compared
R2729 T8961 T8934 advcl compared,appeared
R2730 T8962 T8961 prep to,compared
R2731 T8963 T8962 pobj controls,to
R2732 T8964 T8963 cc and,controls
R2733 T8965 T8966 compound Alk5,mutants
R2734 T8966 T8963 conj mutants,controls
R2735 T8967 T8934 punct ", ",appeared
R2736 T8968 T8934 advcl implying,appeared
R2737 T8969 T8970 mark that,involved
R2738 T8970 T8968 ccomp involved,implying
R2739 T8971 T8972 npadvmod ALK2,mediated
R2740 T8972 T8974 amod mediated,signaling
R2741 T8973 T8972 punct -,mediated
R2742 T8974 T8970 nsubjpass signaling,involved
R2743 T8975 T8970 auxpass is,involved
R2744 T8976 T8970 prep in,involved
R2745 T8977 T8978 amod smooth,muscle
R2746 T8978 T8979 compound muscle,differentiation
R2747 T8979 T8976 pobj differentiation,in
R2748 T8980 T8979 compound cell,differentiation
R2749 T8981 T8982 mark as,suggested
R2750 T8982 T8970 advcl suggested,involved
R2751 T8983 T8982 advmod previously,suggested
R2752 T8984 T8985 punct [,12
R2753 T8985 T8970 parataxis 12,involved
R2754 T8986 T8985 punct ],12
R2755 T8987 T8934 punct .,appeared
R2756 T8989 T8990 aux To,conclude
R2757 T8990 T8991 advcl conclude,appear
R2758 T8992 T8991 punct ", ",appear
R2759 T8993 T8994 mark while,demonstrate
R2760 T8994 T8991 advcl demonstrate,appear
R2761 T8995 T8996 preconj both,Alk2
R2762 T8996 T8997 nmod Alk2,mutants
R2763 T8997 T8994 nsubj mutants,demonstrate
R2764 T8998 T8996 cc and,Alk2
R2765 T8999 T8996 conj Alk5,Alk2
R2766 T9000 T9001 det a,failure
R2767 T9001 T8994 dobj failure,demonstrate
R2768 T9002 T9001 prep in,failure
R2769 T9003 T9004 preconj both,rotation
R2770 T9004 T9002 pobj rotation,in
R2771 T9005 T9004 det the,rotation
R2772 T9006 T9004 prep of,rotation
R2773 T9007 T9008 det the,sac
R2774 T9008 T9006 pobj sac,of
R2775 T9009 T9008 amod aortic,sac
R2776 T9010 T9004 cc and,rotation
R2777 T9011 T9012 det the,OFT
R2778 T9012 T9004 conj OFT,rotation
R2779 T9013 T9012 amod truncal,OFT
R2780 T9014 T9002 punct ", ",in
R2781 T9015 T9002 cc and,in
R2782 T9016 T9002 conj in,in
R2783 T9017 T9018 det the,formation
R2784 T9018 T9016 pobj formation,in
R2785 T9019 T9018 prep of,formation
R2786 T9020 T9021 det the,septum
R2787 T9021 T9019 pobj septum,of
R2788 T9022 T9021 compound AP,septum
R2789 T9023 T8991 punct ", ",appear
R2790 T9024 T9025 det the,mechanisms
R2791 T9025 T8991 nsubj mechanisms,appear
R2792 T9026 T9025 amod pathogenetic,mechanisms
R2793 T9027 T9025 prep behind,mechanisms
R2794 T9028 T9029 det these,defects
R2795 T9029 T9027 pobj defects,behind
R2796 T9030 T9031 advmod remarkably,different
R2797 T9031 T8991 oprd different,appear
R2798 T9032 T8991 punct .,appear

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T8276 17-30 UBERON:0004145 denotes outflow tract
T8277 31-36 GO_UBERON_EXT:lumen denotes lumen
T8278 103-113 UBERON:0005432 denotes aortic sac
T8279 140-145 UBERON:0000948 denotes heart
T8280 177-187 UBERON:0003104 denotes mesenchyme
T8281 205-207 UBERON:0002342 denotes NC
T8282 233-243 UBERON:0005432 denotes aortic sac
T8283 267-270 _FRAGMENT denotes 4th
T8284 279-283 UBERON:0003121 denotes PAAs
T8285 275-283 UBERON:0003123 denotes 6th PAAs
T8286 328-345 _FRAGMENT denotes aortico-pulmonary
T8287 351-357 UBERON:0006207 denotes septum
T8288 374-381 UBERON:0002061 denotes truncal
T8289 399-434 UBERON:0006207 denotes aortico-pulmonary septation complex
T8290 447-457 UBERON:0005432 denotes aortic sac
T8291 493-500 UBERON:0000922 denotes embryos
T8292 528-539 UBERON:0006060 denotes conotruncal
T8293 566-573 UBERON:0002061 denotes truncus
T8294 578-583 UBERON:0003983 denotes conus
T8295 672-679 UBERON:0002061 denotes truncal
T8296 684-689 UBERON:0003983 denotes conal
T8297 725-729 PR_EXT:000000047 denotes Alk5
T8298 730-734 PR_EXT:000017435 denotes Wnt1
T8299 739-746 SO_EXT:sequence_altered_entity denotes mutants
T8300 751-764 UBERON:0004145 denotes outflow tract
T8301 830-841 UBERON:0006060 denotes conotruncal
T8302 937-947 UBERON:0005432 denotes aortic sac
T8303 1035-1045 UBERON:0005432 denotes aortic sac
T8304 1050-1057 UBERON:0002061 denotes truncal
T8305 1058-1061 UBERON:0004145 denotes OFT
T8306 1165-1174 UBERON:0006207 denotes AP-septal
T8307 1175-1185 UBERON:0003104 denotes mesenchyme
T8308 1215-1218 UBERON:0004145 denotes OFT
T8309 1226-1231 UBERON:0000947 denotes aorta
T8310 1240-1255 UBERON:0002333 denotes pulmonary trunk
T8311 1318-1324 UBERON:0000479 denotes tissue
T8312 1345-1347 UBERON:0002342 denotes NC
T8313 1374-1379 PR_EXT:000003675 denotes α-SMA
T8314 1387-1402 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T8315 1408-1421 UBERON:0001135 denotes smooth muscle
T8316 1435-1439 PR_EXT:000000047 denotes Alk5
T8317 1440-1444 PR_EXT:000017435 denotes Wnt1
T8318 1449-1456 SO_EXT:sequence_altered_entity denotes mutants
T8319 1492-1502 UBERON:0005432 denotes aortic sac
T8320 1507-1514 UBERON:0002061 denotes truncal
T8321 1515-1518 UBERON:0004145 denotes OFT
T8322 1574-1583 UBERON:0006207 denotes AP-septum
T8323 1694-1698 CL_EXT:neural_crest_cell denotes NCCs
T8324 1712-1715 UBERON:0004145 denotes OFT
T8325 1724-1726 UBERON:0002342 denotes NC
T8326 1735-1740 CL_GO_EXT:cell denotes cells
T8327 1773-1783 UBERON:0005432 denotes aortic sac
T8328 1806-1816 UBERON:0003123 denotes sixth PAAs
T8329 1825-1832 UBERON:0002061 denotes truncus
T8330 1853-1857 PR_EXT:000003675 denotes αSMA
T8331 1911-1913 UBERON:0002342 denotes NC
T8332 1923-1930 SO_EXT:sequence_altered_entity denotes mutants
T8333 1946-1961 PR_EXT:BMP_type_1_receptor denotes type I receptor
T8334 1953-1961 GO_EXT:0004872 denotes receptor
T8335 1963-1967 PR_EXT:000000067 denotes Alk2
T8336 1998-2002 PR_EXT:000000067 denotes Alk2
T8337 2003-2007 PR_EXT:000017435 denotes Wnt1
T8338 2012-2019 SO_EXT:sequence_altered_entity denotes mutants
T8339 2041-2051 UBERON:0005432 denotes aortic sac
T8340 2056-2063 UBERON:0002061 denotes truncal
T8341 2064-2067 UBERON:0004145 denotes OFT
T8342 2107-2111 PR_EXT:000000047 denotes Alk5
T8343 2112-2116 PR_EXT:000017435 denotes Wnt1
T8344 2121-2128 SO_EXT:sequence_altered_entity denotes mutants
T8345 2142-2146 PR_EXT:000000067 denotes Alk2
T8346 2147-2154 SO_EXT:sequence_altered_entity denotes mutants
T8347 2175-2179 UBERON:0004363 denotes PAAs
T8348 2219-2223 PR_EXT:000000067 denotes Alk2
T8349 2224-2228 PR_EXT:000017435 denotes Wnt1
T8350 2233-2240 SO_EXT:sequence_altered_entity denotes mutants
T8351 2274-2280 UBERON:0003037 denotes septal
T8352 2281-2287 UBERON:0000479 denotes tissue
T8353 2300-2303 _FRAGMENT denotes 4th
T8354 2312-2316 UBERON:0003121 denotes PAAs
T8355 2308-2316 UBERON:0003123 denotes 6th PAAs
T8356 2344-2350 UBERON:0003037 denotes septal
T8357 2351-2361 UBERON:0003104 denotes mesenchyme
T8358 2370-2374 PR_EXT:000000067 denotes Alk2
T8359 2412-2419 UBERON:0002061 denotes truncal
T8360 2445-2454 UBERON:0006207 denotes AP septum
T8361 2474-2482 UBERON:0003123 denotes 6th PAAs
T8362 2610-2617 GO_EXT:biological_movement_or_translocation_process denotes migrate
T8363 2625-2635 UBERON:0005432 denotes aortic sac
T8364 2644-2651 UBERON:0002061 denotes truncal
T8365 2700-2704 PR_EXT:000003675 denotes αSMA
T8366 2756-2760 PR_EXT:000000047 denotes Alk5
T8367 2761-2768 SO_EXT:sequence_altered_entity denotes mutants
T8368 2784-2788 PR_EXT:000000067 denotes ALK2
T8369 2798-2807 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T8370 2823-2836 UBERON:0001135 denotes smooth muscle
T8371 2823-2841 CL:0000192 denotes smooth muscle cell
T8372 2837-2841 CL_GO_EXT:cell denotes cell
T8373 2837-2857 GO:0030154 denotes cell differentiation
T8374 2912-2916 PR_EXT:000000067 denotes Alk2
T8375 2921-2925 PR_EXT:000000047 denotes Alk5
T8376 2926-2933 SO_EXT:sequence_altered_entity denotes mutants
T8377 2984-2994 UBERON:0005432 denotes aortic sac
T8378 3003-3010 UBERON:0002061 denotes truncal
T8379 3011-3014 UBERON:0004145 denotes OFT
T8380 3044-3053 UBERON:0006207 denotes AP septum
R2179 T8284 T8283 _lexicallyChainedTo PAAs,4th
R2180 T8287 T8286 _lexicallyChainedTo septum,aortico-pulmonary
R2181 T8354 T8353 _lexicallyChainedTo PAAs,4th

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T8248 2300-2303 _FRAGMENT denotes 4th
T8184 17-30 UBERON:0004145 denotes outflow tract
T8185 103-113 UBERON:0005432 denotes aortic sac
T8186 140-145 UBERON:0000948 denotes heart
T8187 177-187 UBERON:0003104 denotes mesenchyme
T8188 205-207 UBERON:0002342 denotes NC
T8189 233-243 UBERON:0005432 denotes aortic sac
T8190 267-270 _FRAGMENT denotes 4th
T8191 279-283 UBERON:0003121 denotes PAAs
T8192 275-283 UBERON:0003123 denotes 6th PAAs
T8193 328-345 _FRAGMENT denotes aortico-pulmonary
T8194 351-357 UBERON:0006207 denotes septum
T8195 374-381 UBERON:0002061 denotes truncal
T8196 399-434 UBERON:0006207 denotes aortico-pulmonary septation complex
T8197 447-457 UBERON:0005432 denotes aortic sac
T8198 493-500 UBERON:0000922 denotes embryos
T8199 528-539 UBERON:0006060 denotes conotruncal
T8200 566-573 UBERON:0002061 denotes truncus
T8201 578-583 UBERON:0003983 denotes conus
T8202 672-679 UBERON:0002061 denotes truncal
T8203 684-689 UBERON:0003983 denotes conal
T8204 725-729 PR:000000047 denotes Alk5
T8205 730-734 PR:000017435 denotes Wnt1
T8206 751-764 UBERON:0004145 denotes outflow tract
T8207 830-841 UBERON:0006060 denotes conotruncal
T8208 937-947 UBERON:0005432 denotes aortic sac
T8209 1035-1045 UBERON:0005432 denotes aortic sac
T8210 1050-1057 UBERON:0002061 denotes truncal
T8211 1058-1061 UBERON:0004145 denotes OFT
T8212 1165-1174 UBERON:0006207 denotes AP-septal
T8213 1175-1185 UBERON:0003104 denotes mesenchyme
T8214 1215-1218 UBERON:0004145 denotes OFT
T8215 1226-1231 UBERON:0000947 denotes aorta
T8216 1240-1255 UBERON:0002333 denotes pulmonary trunk
T8217 1318-1324 UBERON:0000479 denotes tissue
T8218 1345-1347 UBERON:0002342 denotes NC
T8219 1374-1379 PR:000003675 denotes α-SMA
T8220 1408-1421 UBERON:0001135 denotes smooth muscle
T8221 1435-1439 PR:000000047 denotes Alk5
T8222 1440-1444 PR:000017435 denotes Wnt1
T8223 1492-1502 UBERON:0005432 denotes aortic sac
T8224 1507-1514 UBERON:0002061 denotes truncal
T8225 1515-1518 UBERON:0004145 denotes OFT
T8226 1574-1583 UBERON:0006207 denotes AP-septum
T8227 1712-1715 UBERON:0004145 denotes OFT
T8228 1724-1726 UBERON:0002342 denotes NC
T8229 1773-1783 UBERON:0005432 denotes aortic sac
T8230 1806-1816 UBERON:0003123 denotes sixth PAAs
T8231 1825-1832 UBERON:0002061 denotes truncus
T8232 1853-1857 PR:000003675 denotes αSMA
T8233 1911-1913 UBERON:0002342 denotes NC
T8234 1963-1967 PR:000000067 denotes Alk2
T8235 1998-2002 PR:000000067 denotes Alk2
T8236 2003-2007 PR:000017435 denotes Wnt1
T8237 2041-2051 UBERON:0005432 denotes aortic sac
T8238 2056-2063 UBERON:0002061 denotes truncal
T8239 2064-2067 UBERON:0004145 denotes OFT
T8240 2107-2111 PR:000000047 denotes Alk5
T8241 2112-2116 PR:000017435 denotes Wnt1
T8242 2142-2146 PR:000000067 denotes Alk2
T8243 2175-2179 UBERON:0004363 denotes PAAs
T8244 2219-2223 PR:000000067 denotes Alk2
T8245 2224-2228 PR:000017435 denotes Wnt1
T8246 2274-2280 UBERON:0003037 denotes septal
T8247 2281-2287 UBERON:0000479 denotes tissue
T8249 2312-2316 UBERON:0003121 denotes PAAs
T8250 2308-2316 UBERON:0003123 denotes 6th PAAs
T8251 2344-2350 UBERON:0003037 denotes septal
T8252 2351-2361 UBERON:0003104 denotes mesenchyme
T8253 2370-2374 PR:000000067 denotes Alk2
T8254 2412-2419 UBERON:0002061 denotes truncal
T8255 2445-2454 UBERON:0006207 denotes AP septum
T8256 2474-2482 UBERON:0003123 denotes 6th PAAs
T8257 2625-2635 UBERON:0005432 denotes aortic sac
T8258 2644-2651 UBERON:0002061 denotes truncal
T8259 2700-2704 PR:000003675 denotes αSMA
T8260 2756-2760 PR:000000047 denotes Alk5
T8261 2784-2788 PR:000000067 denotes ALK2
T8262 2823-2836 UBERON:0001135 denotes smooth muscle
T8263 2823-2841 CL:0000192 denotes smooth muscle cell
T8264 2837-2857 GO:0030154 denotes cell differentiation
T8265 2912-2916 PR:000000067 denotes Alk2
T8266 2921-2925 PR:000000047 denotes Alk5
T8267 2984-2994 UBERON:0005432 denotes aortic sac
T8268 3003-3010 UBERON:0002061 denotes truncal
T8269 3011-3014 UBERON:0004145 denotes OFT
T8270 3044-3053 UBERON:0006207 denotes AP septum
R2176 T8191 T8190 _lexicallyChainedTo PAAs,4th
R2177 T8194 T8193 _lexicallyChainedTo septum,aortico-pulmonary
R2178 T8249 T8248 _lexicallyChainedTo PAAs,4th