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{"project":"craft-ca-core-dev","denotations":[{"id":"T402","span":{"begin":10,"end":14},"obj":"PR:000000047"},{"id":"T403","span":{"begin":32,"end":44},"obj":"UBERON:0002342"},{"id":"T404","span":{"begin":78,"end":90},"obj":"UBERON:0002342"},{"id":"T405","span":{"begin":91,"end":105},"obj":"GO:0006915"},{"id":"T406","span":{"begin":117,"end":130},"obj":"UBERON:0004145"},{"id":"T407","span":{"begin":171,"end":185},"obj":"UBERON:0004535"},{"id":"T408","span":{"begin":223,"end":228},"obj":"GO:0007567"},{"id":"T409","span":{"begin":240,"end":246},"obj":"NCBITaxon:9606"},{"id":"T410","span":{"begin":337,"end":346},"obj":"_FRAGMENT"},{"id":"T411","span":{"begin":379,"end":381},"obj":"_FRAGMENT"},{"id":"T412","span":{"begin":402,"end":414},"obj":"_FRAGMENT"},{"id":"T413","span":{"begin":420,"end":425},"obj":"GO:0001755"},{"id":"T414","span":{"begin":348,"end":363},"obj":"_FRAGMENT"},{"id":"T415","span":{"begin":420,"end":425},"obj":"GO:0030154"},{"id":"T416","span":{"begin":382,"end":393},"obj":"_FRAGMENT"},{"id":"T417","span":{"begin":415,"end":425},"obj":"CL:0002248"},{"id":"T418","span":{"begin":394,"end":414},"obj":"UBERON:0000095"},{"id":"T419","span":{"begin":433,"end":438},"obj":"PR:000000046"},{"id":"T420","span":{"begin":433,"end":460},"obj":"GO:0007179"},{"id":"T421","span":{"begin":493,"end":505},"obj":"UBERON:0002342"},{"id":"T422","span":{"begin":493,"end":522},"obj":"GO:0014032"},{"id":"T423","span":{"begin":629,"end":634},"obj":"PR:000000046"},{"id":"T424","span":{"begin":651,"end":655},"obj":"PR:000000047"},{"id":"T425","span":{"begin":676,"end":681},"obj":"NCBITaxon:10088"},{"id":"T426","span":{"begin":682,"end":694},"obj":"UBERON:0002342"},{"id":"T427","span":{"begin":734,"end":738},"obj":"PR:000000047"},{"id":"T428","span":{"begin":755,"end":769},"obj":"UBERON:0004535"},{"id":"T429","span":{"begin":774,"end":784},"obj":"UBERON:0006562"}],"relations":[{"id":"R2","pred":"_lexicallyChainedTo","subj":"T411","obj":"T414"},{"id":"R3","pred":"_lexicallyChainedTo","subj":"T412","obj":"T411"},{"id":"R4","pred":"_lexicallyChainedTo","subj":"T413","obj":"T412"},{"id":"R1","pred":"_lexicallyChainedTo","subj":"T411","obj":"T410"},{"id":"R5","pred":"_lexicallyChainedTo","subj":"T415","obj":"T411"},{"id":"R6","pred":"_lexicallyChainedTo","subj":"T417","obj":"T416"}],"text":"Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects\n\nAbstract\nBackground\nCongenital cardiovascular diseases are the most common form of birth defects in humans. A substantial portion of these defects has been associated with inappropriate induction, migration, differentiation and patterning of pluripotent cardiac neural crest stem cells. While TGF-β-superfamily signaling has been strongly implicated in neural crest cell development, the detailed molecular signaling mechanisms in vivo are still poorly understood.\n\nResults\nWe deleted the TGF-β type I receptor Alk5 specifically in the mouse neural crest cell lineage. Failure in signaling via ALK5 leads to severe cardiovascular and pharyngeal defects, including inappropriate remodeling of pharyngeal arch a"}