PMC:1630425 / 19269-20023 JSONTXT

{"project":"2_test","denotations":[{"id":"17049089-2336393-1690149","span":{"begin":33,"end":34},"obj":"2336393"},{"id":"17049089-15501469-1690150","span":{"begin":490,"end":492},"obj":"15501469"}],"text":"In the original CGR proposition [1] the mid coordinate, 1/2, is invariably used as the initial position. Because this position cannot be mapped back to a real sequence this at first appeared as a reasonable proposition even if not fundamentally superior to any of the other boundary positions such as 0 and 1. However, seeding all iterations equally causes an artifactual conservation of the beginning of the sequence which will bias sequence entropy calculations based on map coordinates [15], particularly for small sequences: the first iteration can only produce two coordinates, 1/4 or 3/4, the second iteration will produce one of 4 possibilities: 1/8, 3/8, 5/8 or 7/8, etc. This will cause some extent of artfactual high density at those positions."}