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Id Subject Object Predicate Lexical cue
T3689 2279-2283 NN denotes rate
T3690 2284-2292 VBG denotes limiting
T3691 2283-2284 HYPH denotes -
T3692 2298-2300 IN denotes of
T3693 2301-2311 NN denotes glycolysis
T3694 2311-2313 , denotes ,
T3695 2313-2315 PRP denotes we
T3696 2323-2330 IN denotes whether
T3697 2346-2355 VBD denotes presented
T3698 2331-2337 NN denotes RanBP2
T3699 2341-2345 NNS denotes mice
T3700 2337-2338 SYM denotes +
T3701 2338-2339 HYPH denotes /
T3702 2339-2340 SYM denotes −
T3703 2356-2368 NNS denotes disturbances
T3704 2369-2371 IN denotes in
T3705 2372-2375 NN denotes HKI
T3706 2375-2377 , denotes ,
T3707 2377-2382 NN denotes Cox11
T3708 2382-2384 , denotes ,
T3709 2384-2387 CC denotes and
T3710 2388-2394 NN denotes energy
T3711 2395-2406 NN denotes homeostasis
T3712 2406-2407 . denotes .
T12535 11-20 NN denotes Insertion
T12536 21-32 NN denotes Mutagenesis
T12537 33-35 IN denotes of
T12538 36-39 DT denotes the
T12539 54-58 NN denotes Gene
T12540 40-46 JJ denotes Murine
T12541 47-53 NN denotes RanBP2
T12542 58-199 sentence denotes (A) Diagram of the genomic region of RanBP2 disrupted by insertion trap mutagenesis with a bicistronic reporter vector between exon 1 and 2.
T12543 59-60 -LRB- denotes (
T12544 60-61 LS denotes A
T12545 63-70 NN denotes Diagram
T12546 61-62 -RRB- denotes )
T12547 71-73 IN denotes of
T12548 74-77 DT denotes the
T12549 86-92 NN denotes region
T12550 78-85 JJ denotes genomic
T12551 93-95 IN denotes of
T12552 96-102 NN denotes RanBP2
T12553 103-112 VBN denotes disrupted
T12554 113-115 IN denotes by
T12555 116-125 NN denotes insertion
T12556 126-130 NN denotes trap
T12557 131-142 NN denotes mutagenesis
T12558 143-147 IN denotes with
T12559 148-149 DT denotes a
T12560 171-177 NN denotes vector
T12561 150-161 JJ denotes bicistronic
T12562 162-170 NN denotes reporter
T12563 178-185 IN denotes between
T12564 186-190 NN denotes exon
T12565 191-192 CD denotes 1
T12566 193-196 CC denotes and
T12567 197-198 CD denotes 2
T12568 198-199 . denotes .
T12569 199-276 sentence denotes The bicistronic transcript produces two proteins under regulation of RanBP2.
T12570 200-203 DT denotes The
T12571 216-226 NN denotes transcript
T12572 204-215 JJ denotes bicistronic
T12573 227-235 VBZ denotes produces
T12574 236-239 CD denotes two
T12575 240-248 NN denotes proteins
T12576 249-254 IN denotes under
T12577 255-265 NN denotes regulation
T12578 266-268 IN denotes of
T12579 269-275 NN denotes RanBP2
T12580 275-276 . denotes .
T12581 276-509 sentence denotes Upon splicing of RanBP2, a fusion between exon 1 and β-geo (a fusion between the β-gal and neo genes) is generated, while human placental alkaline phophatase (PLAP) is independently translated using the internal ribosome entry site.
T12582 277-281 IN denotes Upon
T12583 382-391 VBN denotes generated
T12584 282-290 NN denotes splicing
T12585 291-293 IN denotes of
T12586 294-300 NN denotes RanBP2
T12587 300-302 , denotes ,
T12588 302-303 DT denotes a
T12589 304-310 NN denotes fusion
T12590 311-318 IN denotes between
T12591 319-323 NN denotes exon
T12592 324-325 CD denotes 1
T12593 326-329 CC denotes and
T12594 330-331 NN denotes β
T12595 332-335 NN denotes geo
T12596 331-332 HYPH denotes -
T12597 336-337 -LRB- denotes (
T12598 337-338 DT denotes a
T12599 339-345 NN denotes fusion
T12600 346-353 IN denotes between
T12601 354-357 DT denotes the
T12602 372-377 NNS denotes genes
T12603 358-359 NN denotes β
T12604 360-363 NN denotes gal
T12605 359-360 HYPH denotes -
T12606 364-367 CC denotes and
T12607 368-371 NN denotes neo
T12608 377-378 -RRB- denotes )
T12609 379-381 VBZ denotes is
T12610 391-393 , denotes ,
T12611 393-398 IN denotes while
T12612 459-469 VBN denotes translated
T12613 399-404 JJ denotes human
T12614 424-434 NN denotes phophatase
T12615 405-414 JJ denotes placental
T12616 415-423 NN denotes alkaline
T12617 435-436 -LRB- denotes (
T12618 436-440 NN denotes PLAP
T12619 440-441 -RRB- denotes )
T12620 442-444 VBZ denotes is
T12621 445-458 RB denotes independently
T12622 470-475 VBG denotes using
T12623 476-479 DT denotes the
T12624 504-508 NN denotes site
T12625 480-488 JJ denotes internal
T12626 498-503 NN denotes entry
T12627 489-497 NN denotes ribosome
T12628 508-509 . denotes .
T12629 509-676 sentence denotes Consistent with previous studies, the expression of the former is directed to cell bodies, while expression of the latter is targeted to the axonal processes [67,68].
T12630 510-520 JJ denotes Consistent
T12631 576-584 VBN denotes directed
T12632 521-525 IN denotes with
T12633 526-534 JJ denotes previous
T12634 535-542 NNS denotes studies
T12635 542-544 , denotes ,
T12636 544-547 DT denotes the
T12637 548-558 NN denotes expression
T12638 559-561 IN denotes of
T12639 562-565 DT denotes the
T12640 566-572 JJ denotes former
T12641 573-575 VBZ denotes is
T12642 585-587 IN denotes to
T12643 588-592 NN denotes cell
T12644 593-599 NNS denotes bodies
T12645 599-601 , denotes ,
T12646 601-606 IN denotes while
T12647 635-643 VBN denotes targeted
T12648 607-617 NN denotes expression
T12649 618-620 IN denotes of
T12650 621-624 DT denotes the
T12651 625-631 JJ denotes latter
T12652 632-634 VBZ denotes is
T12653 644-646 IN denotes to
T12654 647-650 DT denotes the
T12655 658-667 NNS denotes processes
T12656 651-657 JJ denotes axonal
T12657 668-669 -LRB- denotes [
T12658 672-674 CD denotes 68
T12659 669-671 CD denotes 67
T12660 671-672 , denotes ,
T12661 674-675 -RRB- denotes ]
T12662 675-676 . denotes .
T12663 676-752 sentence denotes Transcriptional 5′ RACE analysis detects a fusion between exon 1 and β-geo.
T12664 677-692 JJ denotes Transcriptional
T12665 701-709 NN denotes analysis
T12666 693-694 CD denotes 5
T12667 694-695 SYM denotes ′
T12668 696-700 NN denotes RACE
T12669 710-717 VBZ denotes detects
T12670 718-719 DT denotes a
T12671 720-726 NN denotes fusion
T12672 727-734 IN denotes between
T12673 735-739 NN denotes exon
T12674 740-741 CD denotes 1
T12675 742-745 CC denotes and
T12676 746-747 NN denotes β
T12677 748-751 NN denotes geo
T12678 747-748 HYPH denotes -
T12679 751-752 . denotes .
T12680 752-1017 sentence denotes (B) Southern analysis of the RanBP2 locus of wild-type and heterozygous genomic DNA of tails of F1 mice digested with PpuMI (left panel) and HindIII (right panel) with probes at the 3′ (left panel) and 5′ (right panel) flanking regions of the insertion breakpoint.
T12681 753-754 -LRB- denotes (
T12682 754-755 LS denotes B
T12683 766-774 NN denotes analysis
T12684 755-756 -RRB- denotes )
T12685 757-765 NNP denotes Southern
T12686 775-777 IN denotes of
T12687 778-781 DT denotes the
T12688 789-794 NN denotes locus
T12689 782-788 NN denotes RanBP2
T12690 795-797 IN denotes of
T12691 798-802 JJ denotes wild
T12692 803-807 NN denotes type
T12693 802-803 HYPH denotes -
T12694 833-836 NN denotes DNA
T12695 808-811 CC denotes and
T12696 812-824 JJ denotes heterozygous
T12697 825-832 JJ denotes genomic
T12698 837-839 IN denotes of
T12699 840-845 NNS denotes tails
T12700 846-848 IN denotes of
T12701 849-851 NN denotes F1
T12702 852-856 NNS denotes mice
T12703 857-865 VBN denotes digested
T12704 866-870 IN denotes with
T12705 871-876 NN denotes PpuMI
T12706 877-878 -LRB- denotes (
T12707 883-888 NN denotes panel
T12708 878-882 JJ denotes left
T12709 888-889 -RRB- denotes )
T12710 890-893 CC denotes and
T12711 894-901 NN denotes HindIII
T12712 902-903 -LRB- denotes (
T12713 909-914 NN denotes panel
T12714 903-908 JJ denotes right
T12715 914-915 -RRB- denotes )
T12716 916-920 IN denotes with
T12717 921-927 NNS denotes probes
T12718 928-930 IN denotes at
T12719 931-934 DT denotes the
T12720 981-988 NNS denotes regions
T12721 935-936 CD denotes 3
T12722 936-937 SYM denotes ′
T12723 938-939 -LRB- denotes (
T12724 944-949 NN denotes panel
T12725 939-943 JJ denotes left
T12726 949-950 -RRB- denotes )
T12727 951-954 CC denotes and
T12728 955-956 CD denotes 5
T12729 956-957 SYM denotes ′
T12730 958-959 -LRB- denotes (
T12731 965-970 NN denotes panel
T12732 959-964 JJ denotes right
T12733 970-971 -RRB- denotes )
T12734 972-980 NN denotes flanking
T12735 989-991 IN denotes of
T12736 992-995 DT denotes the
T12737 1006-1016 NN denotes breakpoint
T12738 996-1005 NN denotes insertion
T12739 1016-1017 . denotes .
T12740 1017-1078 sentence denotes Q1 is a cosmid containing the RanBP2 gene up to exon 20 [4].
T12741 1018-1020 NN denotes Q1
T12742 1021-1023 VBZ denotes is
T12743 1024-1025 DT denotes a
T12744 1026-1032 NN denotes cosmid
T12745 1033-1043 VBG denotes containing
T12746 1044-1047 DT denotes the
T12747 1055-1059 NN denotes gene
T12748 1048-1054 NN denotes RanBP2
T12749 1060-1062 IN denotes up
T12750 1063-1065 IN denotes to
T12751 1066-1070 NN denotes exon
T12752 1071-1073 CD denotes 20
T12753 1074-1075 -LRB- denotes [
T12754 1075-1076 CD denotes 4
T12755 1076-1077 -RRB- denotes ]
T12756 1077-1078 . denotes .
T12757 1078-1206 sentence denotes (C) Lateroventral view of a whole-mount stain of a ~12.5 dpc heterozygous embryo for PLAP and β-gal (inset picture) activities.
T12758 1079-1080 -LRB- denotes (
T12759 1080-1081 LS denotes C
T12760 1097-1101 NN denotes view
T12761 1081-1082 -RRB- denotes )
T12762 1083-1096 JJ denotes Lateroventral
T12763 1102-1104 IN denotes of
T12764 1105-1106 DT denotes a
T12765 1119-1124 NN denotes stain
T12766 1107-1112 JJ denotes whole
T12767 1113-1118 NN denotes mount
T12768 1112-1113 HYPH denotes -
T12769 1125-1127 IN denotes of
T12770 1128-1129 DT denotes a
T12771 1153-1159 NN denotes embryo
T12772 1130-1131 SYM denotes ~
T12773 1131-1135 CD denotes 12.5
T12774 1136-1139 NN denotes dpc
T12775 1140-1152 JJ denotes heterozygous
T12776 1160-1163 IN denotes for
T12777 1164-1168 NN denotes PLAP
T12778 1195-1205 NNS denotes activities
T12779 1169-1172 CC denotes and
T12780 1173-1174 NN denotes β
T12781 1175-1178 NN denotes gal
T12782 1174-1175 HYPH denotes -
T12783 1179-1180 -LRB- denotes (
T12784 1186-1193 NN denotes picture
T12785 1180-1185 NN denotes inset
T12786 1193-1194 -RRB- denotes )
T12787 1205-1206 . denotes .
T12788 1206-1373 sentence denotes Although PLAP was broadly expressed (e.g., somites, limbs, and CNS), the PLAP and β-Gal (inset picture) expression was particularly high in the optic vesicle (arrow).
T12789 1207-1215 IN denotes Although
T12790 1233-1242 VBN denotes expressed
T12791 1216-1220 NN denotes PLAP
T12792 1221-1224 VBD denotes was
T12793 1225-1232 RB denotes broadly
T12794 1322-1325 VBD denotes was
T12795 1243-1244 -LRB- denotes (
T12796 1244-1248 FW denotes e.g.
T12797 1250-1257 NNS denotes somites
T12798 1248-1250 , denotes ,
T12799 1257-1259 , denotes ,
T12800 1259-1264 NNS denotes limbs
T12801 1264-1266 , denotes ,
T12802 1266-1269 CC denotes and
T12803 1270-1273 NN denotes CNS
T12804 1273-1274 -RRB- denotes )
T12805 1274-1276 , denotes ,
T12806 1276-1279 DT denotes the
T12807 1311-1321 NN denotes expression
T12808 1280-1284 NN denotes PLAP
T12809 1285-1288 CC denotes and
T12810 1289-1290 NN denotes β
T12811 1291-1294 NN denotes Gal
T12812 1290-1291 HYPH denotes -
T12813 1295-1296 -LRB- denotes (
T12814 1302-1309 NN denotes picture
T12815 1296-1301 NN denotes inset
T12816 1309-1310 -RRB- denotes )
T12817 1326-1338 RB denotes particularly
T12818 1339-1343 JJ denotes high
T12819 1344-1346 IN denotes in
T12820 1347-1350 DT denotes the
T12821 1357-1364 NN denotes vesicle
T12822 1351-1356 JJ denotes optic
T12823 1365-1366 -LRB- denotes (
T12824 1366-1371 NN denotes arrow
T12825 1371-1372 -RRB- denotes )
T12826 1372-1373 . denotes .
T12827 1373-1478 sentence denotes X-gal single (D) and combined staining with PLAP (E) of a retinal section of a 3-mo-old RanBP2+/− mouse.
T12828 1374-1375 NN denotes X
T12829 1376-1379 NN denotes gal
T12830 1375-1376 HYPH denotes -
T12831 1404-1412 NN denotes staining
T12832 1380-1386 JJ denotes single
T12833 1387-1388 -LRB- denotes (
T12834 1388-1389 NN denotes D
T12835 1389-1390 -RRB- denotes )
T12836 1391-1394 CC denotes and
T12837 1395-1403 JJ denotes combined
T12838 1413-1417 IN denotes with
T12839 1418-1422 NN denotes PLAP
T12840 1423-1424 -LRB- denotes (
T12841 1424-1425 NN denotes E
T12842 1425-1426 -RRB- denotes )
T12843 1427-1429 IN denotes of
T12844 1430-1431 DT denotes a
T12845 1440-1447 NN denotes section
T12846 1432-1439 JJ denotes retinal
T12847 1448-1450 IN denotes of
T12848 1451-1452 DT denotes a
T12849 1472-1477 NN denotes mouse
T12850 1453-1454 CD denotes 3
T12851 1455-1457 NN denotes mo
T12852 1454-1455 HYPH denotes -
T12853 1458-1461 JJ denotes old
T12854 1457-1458 HYPH denotes -
T12855 1462-1468 NN denotes RanBP2
T12856 1468-1469 SYM denotes +
T12857 1469-1470 HYPH denotes /
T12858 1470-1471 SYM denotes −
T12859 1477-1478 . denotes .
T12860 1478-1690 sentence denotes Consistent with previous immunocytochemistry studies, β-Gal activity is detected in the neuroretinal bodies and inner segment compartment of photoreceptors with conspicuously strong expression in ganglion cells.
T12861 1479-1489 JJ denotes Consistent
T12862 1551-1559 VBN denotes detected
T12863 1490-1494 IN denotes with
T12864 1495-1503 JJ denotes previous
T12865 1524-1531 NNS denotes studies
T12866 1504-1523 NN denotes immunocytochemistry
T12867 1531-1533 , denotes ,
T12868 1533-1534 NN denotes β
T12869 1535-1538 NN denotes Gal
T12870 1534-1535 HYPH denotes -
T12871 1539-1547 NN denotes activity
T12872 1548-1550 VBZ denotes is
T12873 1560-1562 IN denotes in
T12874 1563-1566 DT denotes the
T12875 1580-1586 NNS denotes bodies
T12876 1567-1579 JJ denotes neuroretinal
T12877 1587-1590 CC denotes and
T12878 1591-1596 JJ denotes inner
T12879 1605-1616 NN denotes compartment
T12880 1597-1604 NN denotes segment
T12881 1617-1619 IN denotes of
T12882 1620-1634 NNS denotes photoreceptors
T12883 1635-1639 IN denotes with
T12884 1640-1653 RB denotes conspicuously
T12885 1654-1660 JJ denotes strong
T12886 1661-1671 NN denotes expression
T12887 1672-1674 IN denotes in
T12888 1675-1683 NN denotes ganglion
T12889 1684-1689 NNS denotes cells
T12890 1689-1690 . denotes .
T12891 1690-1797 sentence denotes PLAP expression is found throughout the plexiform/synaptic layers and outer segment of photoreceptors (E).
T12892 1691-1695 NN denotes PLAP
T12893 1696-1706 NN denotes expression
T12894 1710-1715 VBN denotes found
T12895 1707-1709 VBZ denotes is
T12896 1716-1726 IN denotes throughout
T12897 1727-1730 DT denotes the
T12898 1750-1756 NNS denotes layers
T12899 1731-1740 JJ denotes plexiform
T12900 1741-1749 JJ denotes synaptic
T12901 1740-1741 HYPH denotes /
T12902 1757-1760 CC denotes and
T12903 1761-1766 JJ denotes outer
T12904 1767-1774 NN denotes segment
T12905 1775-1777 IN denotes of
T12906 1778-1792 NNS denotes photoreceptors
T12907 1793-1794 -LRB- denotes (
T12908 1794-1795 NN denotes E
T12909 1795-1796 -RRB- denotes )
T12910 1796-1797 . denotes .
T12911 1797-2062 sentence denotes GC, ganglion cell; PLAP, human placental alkaline phophatase; ROS, rod outer segment; RIS, rod inner segment; ONL, outer nuclear layer; OPL, outer plexiform (synaptic) layer; INL, inner nuclear layer; IPL, inner plexiform (synaptic) layer; GC, ganglion cell layer.
T12912 1798-1800 NN denotes GC
T12913 1800-1802 , denotes ,
T12914 1802-1810 NN denotes ganglion
T12915 1811-1815 NN denotes cell
T12916 1815-1816 : denotes ;
T12917 1817-1821 NN denotes PLAP
T12918 1821-1823 , denotes ,
T12919 1823-1828 JJ denotes human
T12920 1848-1858 NN denotes phophatase
T12921 1829-1838 JJ denotes placental
T12922 1839-1847 NN denotes alkaline
T12923 1858-1859 : denotes ;
T12924 1860-1863 NN denotes ROS
T12925 1863-1865 , denotes ,
T12926 1865-1868 NN denotes rod
T12927 1875-1882 NN denotes segment
T12928 1869-1874 JJ denotes outer
T12929 1882-1883 : denotes ;
T12930 1884-1887 NN denotes RIS
T12931 1887-1889 , denotes ,
T12932 1889-1892 NN denotes rod
T12933 1899-1906 NN denotes segment
T12934 1893-1898 JJ denotes inner
T12935 1906-1907 : denotes ;
T12936 1908-1911 NN denotes ONL
T12937 1911-1913 , denotes ,
T12938 1913-1918 JJ denotes outer
T12939 1927-1932 NN denotes layer
T12940 1919-1926 JJ denotes nuclear
T12941 1932-1933 : denotes ;
T12942 1934-1937 NN denotes OPL
T12943 1937-1939 , denotes ,
T12944 1939-1944 JJ denotes outer
T12945 1966-1971 NN denotes layer
T12946 1945-1954 JJ denotes plexiform
T12947 1955-1956 -LRB- denotes (
T12948 1956-1964 JJ denotes synaptic
T12949 1964-1965 -RRB- denotes )
T12950 1971-1972 : denotes ;
T12951 1973-1976 NN denotes INL
T12952 1976-1978 , denotes ,
T12953 1978-1983 JJ denotes inner
T12954 1992-1997 NN denotes layer
T12955 1984-1991 JJ denotes nuclear
T12956 1997-1998 : denotes ;
T12957 1999-2002 NN denotes IPL
T12958 2002-2004 , denotes ,
T12959 2004-2009 JJ denotes inner
T12960 2031-2036 NN denotes layer
T12961 2010-2019 JJ denotes plexiform
T12962 2020-2021 -LRB- denotes (
T12963 2021-2029 JJ denotes synaptic
T12964 2029-2030 -RRB- denotes )
T12965 2036-2037 : denotes ;
T12966 2038-2040 NN denotes GC
T12967 2040-2042 , denotes ,
T12968 2042-2050 NN denotes ganglion
T12969 2051-2055 NN denotes cell
T12970 2056-2061 NN denotes layer
T12971 2061-2062 . denotes .
T3660 2144-2145 -RRB- denotes )
T3661 2145-2147 , denotes ,
T3662 2147-2155 JJ denotes profound
T3663 2165-2175 NN denotes modulation
T3664 2156-2158 FW denotes in
T3665 2159-2164 FW denotes vitro
T3666 2176-2178 IN denotes of
T3667 2179-2182 NN denotes HKI
T3668 2183-2192 JJ denotes enzymatic
T3669 2193-2201 NN denotes activity
T3670 2202-2204 IN denotes by
T3671 2205-2211 NN denotes RanBP2
T3672 2212-2215 CC denotes and
T3673 2216-2221 NN denotes Cox11
T3674 2222-2223 -LRB- denotes (
T3675 2223-2229 NN denotes Figure
T3676 2230-2231 CD denotes 2
T3677 2231-2232 -RRB- denotes )
T3678 2232-2234 , denotes ,
T3679 2234-2237 CC denotes and
T3680 2238-2241 DT denotes the
T3681 2251-2255 NN denotes role
T3682 2242-2250 JJ denotes critical
T3683 2256-2258 IN denotes of
T3684 2259-2262 NN denotes HKI
T3685 2263-2265 IN denotes in
T3686 2266-2276 VBG denotes catalyzing
T3687 2277-2278 DT denotes a
T3688 2293-2297 NN denotes step
T3640 0-2407 sentence denotes Figure 4 Insertion Mutagenesis of the Murine RanBP2 Gene (A) Diagram of the genomic region of RanBP2 disrupted by insertion trap mutagenesis with a bicistronic reporter vector between exon 1 and 2. The bicistronic transcript produces two proteins under regulation of RanBP2. Upon splicing of RanBP2, a fusion between exon 1 and β-geo (a fusion between the β-gal and neo genes) is generated, while human placental alkaline phophatase (PLAP) is independently translated using the internal ribosome entry site. Consistent with previous studies, the expression of the former is directed to cell bodies, while expression of the latter is targeted to the axonal processes [67,68]. Transcriptional 5′ RACE analysis detects a fusion between exon 1 and β-geo. (B) Southern analysis of the RanBP2 locus of wild-type and heterozygous genomic DNA of tails of F1 mice digested with PpuMI (left panel) and HindIII (right panel) with probes at the 3′ (left panel) and 5′ (right panel) flanking regions of the insertion breakpoint. Q1 is a cosmid containing the RanBP2 gene up to exon 20 [4]. (C) Lateroventral view of a whole-mount stain of a ~12.5 dpc heterozygous embryo for PLAP and β-gal (inset picture) activities. Although PLAP was broadly expressed (e.g., somites, limbs, and CNS), the PLAP and β-Gal (inset picture) expression was particularly high in the optic vesicle (arrow). X-gal single (D) and combined staining with PLAP (E) of a retinal section of a 3-mo-old RanBP2+/− mouse. Consistent with previous immunocytochemistry studies, β-Gal activity is detected in the neuroretinal bodies and inner segment compartment of photoreceptors with conspicuously strong expression in ganglion cells. PLAP expression is found throughout the plexiform/synaptic layers and outer segment of photoreceptors (E). GC, ganglion cell; PLAP, human placental alkaline phophatase; ROS, rod outer segment; RIS, rod inner segment; ONL, outer nuclear layer; OPL, outer plexiform (synaptic) layer; INL, inner nuclear layer; IPL, inner plexiform (synaptic) layer; GC, ganglion cell layer. In light of the association in vivo of RanBP2 with Cox11 and HKI (Figures 1 and 3), profound in vitro modulation of HKI enzymatic activity by RanBP2 and Cox11 (Figure 2), and the critical role of HKI in catalyzing a rate-limiting step of glycolysis, we probed whether RanBP2+/− mice presented disturbances in HKI, Cox11, and energy homeostasis.
T3641 2063-2065 IN denotes In
T3642 2316-2322 VBD denotes probed
T3643 2066-2071 NN denotes light
T3644 2072-2074 IN denotes of
T3645 2075-2078 DT denotes the
T3646 2079-2090 NN denotes association
T3647 2091-2093 FW denotes in
T3648 2094-2098 FW denotes vivo
T3649 2099-2101 IN denotes of
T3650 2102-2108 NN denotes RanBP2
T3651 2109-2113 IN denotes with
T3652 2114-2119 NN denotes Cox11
T3653 2120-2123 CC denotes and
T3654 2124-2127 NN denotes HKI
T3655 2128-2129 -LRB- denotes (
T3656 2137-2138 CD denotes 1
T3657 2129-2136 NNS denotes Figures
T3658 2139-2142 CC denotes and
T3659 2143-2144 CD denotes 3
R2237 T3669 T3666 pobj activity,of
R2238 T3670 T3663 prep by,modulation
R2239 T3671 T3670 pobj RanBP2,by
R2240 T3672 T3671 cc and,RanBP2
R2241 T3673 T3671 conj Cox11,RanBP2
R2242 T3674 T3675 punct (,Figure
R2243 T3675 T3663 parataxis Figure,modulation
R2244 T3676 T3675 nummod 2,Figure
R2245 T3677 T3675 punct ),Figure
R2246 T3678 T3663 punct ", ",modulation
R2247 T3679 T3663 cc and,modulation
R2248 T3680 T3681 det the,role
R2249 T3681 T3663 conj role,modulation
R2250 T3682 T3681 amod critical,role
R2251 T3683 T3681 prep of,role
R2252 T3684 T3683 pobj HKI,of
R2253 T3685 T3681 prep in,role
R2254 T3686 T3685 pcomp catalyzing,in
R2255 T3687 T3688 det a,step
R2256 T3688 T3686 dobj step,catalyzing
R2257 T3689 T3690 npadvmod rate,limiting
R2258 T3690 T3688 amod limiting,step
R2259 T3691 T3690 punct -,limiting
R2260 T3692 T3688 prep of,step
R2261 T3693 T3692 pobj glycolysis,of
R2262 T3694 T3642 punct ", ",probed
R2263 T3695 T3642 nsubj we,probed
R2264 T3696 T3697 mark whether,presented
R2265 T3697 T3642 ccomp presented,probed
R2266 T3698 T3699 nmod RanBP2,mice
R2267 T3699 T3697 nsubj mice,presented
R2268 T3700 T3698 punct +,RanBP2
R2269 T3701 T3698 punct /,RanBP2
R2270 T3702 T3698 punct −,RanBP2
R2271 T3703 T3697 dobj disturbances,presented
R2272 T3704 T3703 prep in,disturbances
R2273 T3705 T3704 pobj HKI,in
R2274 T3706 T3705 punct ", ",HKI
R2275 T3707 T3705 conj Cox11,HKI
R2276 T3708 T3707 punct ", ",Cox11
R2277 T3709 T3707 cc and,Cox11
R2278 T3710 T3711 compound energy,homeostasis
R2279 T3711 T3707 conj homeostasis,Cox11
R2280 T3712 T3642 punct .,probed
R8251 T12535 T12536 compound Insertion,Mutagenesis
R8252 T12537 T12536 prep of,Mutagenesis
R8253 T12538 T12539 det the,Gene
R8254 T12539 T12537 pobj Gene,of
R8255 T12540 T12539 amod Murine,Gene
R8256 T12541 T12539 compound RanBP2,Gene
R8257 T12543 T12544 punct (,A
R8258 T12544 T12545 meta A,Diagram
R8259 T12546 T12544 punct ),A
R8260 T12547 T12545 prep of,Diagram
R8261 T12548 T12549 det the,region
R8262 T12549 T12547 pobj region,of
R8263 T12550 T12549 amod genomic,region
R8264 T12551 T12549 prep of,region
R8265 T12552 T12551 pobj RanBP2,of
R8266 T12553 T12549 acl disrupted,region
R8267 T12554 T12553 agent by,disrupted
R8268 T12555 T12556 compound insertion,trap
R8269 T12556 T12557 compound trap,mutagenesis
R8270 T12557 T12554 pobj mutagenesis,by
R8271 T12558 T12557 prep with,mutagenesis
R8272 T12559 T12560 det a,vector
R8273 T12560 T12558 pobj vector,with
R8274 T12561 T12560 amod bicistronic,vector
R8275 T12562 T12560 compound reporter,vector
R8276 T12563 T12560 prep between,vector
R8277 T12564 T12565 nmod exon,1
R8278 T12565 T12563 pobj 1,between
R8279 T12566 T12565 cc and,1
R8280 T12567 T12565 conj 2,1
R8281 T12568 T12545 punct .,Diagram
R8282 T12570 T12571 det The,transcript
R8283 T12571 T12573 nsubj transcript,produces
R8284 T12572 T12571 amod bicistronic,transcript
R8285 T12574 T12575 nummod two,proteins
R8286 T12575 T12573 dobj proteins,produces
R8287 T12576 T12573 prep under,produces
R8288 T12577 T12576 pobj regulation,under
R8289 T12578 T12577 prep of,regulation
R8290 T12579 T12578 pobj RanBP2,of
R8291 T12580 T12573 punct .,produces
R8292 T12582 T12583 prep Upon,generated
R8293 T12584 T12582 pobj splicing,Upon
R8294 T12585 T12584 prep of,splicing
R8295 T12586 T12585 pobj RanBP2,of
R8296 T12587 T12583 punct ", ",generated
R8297 T12588 T12589 det a,fusion
R8298 T12589 T12583 nsubjpass fusion,generated
R8299 T12590 T12589 prep between,fusion
R8300 T12591 T12590 pobj exon,between
R8301 T12592 T12591 nummod 1,exon
R8302 T12593 T12591 cc and,exon
R8303 T12594 T12595 compound β,geo
R8304 T12595 T12591 conj geo,exon
R8305 T12596 T12595 punct -,geo
R8306 T12597 T12595 punct (,geo
R8307 T12598 T12599 det a,fusion
R8308 T12599 T12595 appos fusion,geo
R8309 T12600 T12599 prep between,fusion
R8310 T12601 T12602 det the,genes
R8311 T12602 T12600 pobj genes,between
R8312 T12603 T12604 nmod β,gal
R8313 T12604 T12602 nmod gal,genes
R8314 T12605 T12604 punct -,gal
R8315 T12606 T12604 cc and,gal
R8316 T12607 T12604 conj neo,gal
R8317 T12608 T12583 punct ),generated
R8318 T12609 T12583 auxpass is,generated
R8319 T12610 T12583 punct ", ",generated
R8320 T12611 T12612 mark while,translated
R8321 T12612 T12583 advcl translated,generated
R8322 T12613 T12614 amod human,phophatase
R8323 T12614 T12612 nsubjpass phophatase,translated
R8324 T12615 T12614 amod placental,phophatase
R8325 T12616 T12614 compound alkaline,phophatase
R8326 T12617 T12614 punct (,phophatase
R8327 T12618 T12614 appos PLAP,phophatase
R8328 T12619 T12612 punct ),translated
R8329 T12620 T12612 auxpass is,translated
R8330 T12621 T12612 advmod independently,translated
R8331 T12622 T12612 advcl using,translated
R8332 T12623 T12624 det the,site
R8333 T12624 T12622 dobj site,using
R8334 T12625 T12626 amod internal,entry
R8335 T12626 T12624 compound entry,site
R8336 T12627 T12626 compound ribosome,entry
R8337 T12628 T12583 punct .,generated
R8338 T12630 T12631 advcl Consistent,directed
R8339 T12632 T12630 prep with,Consistent
R8340 T12633 T12634 amod previous,studies
R8341 T12634 T12632 pobj studies,with
R8342 T12635 T12631 punct ", ",directed
R8343 T12636 T12637 det the,expression
R8344 T12637 T12631 nsubjpass expression,directed
R8345 T12638 T12637 prep of,expression
R8346 T12639 T12640 det the,former
R8347 T12640 T12638 pobj former,of
R8348 T12641 T12631 auxpass is,directed
R8349 T12642 T12631 prep to,directed
R8350 T12643 T12644 compound cell,bodies
R8351 T12644 T12642 pobj bodies,to
R8352 T12645 T12631 punct ", ",directed
R8353 T12646 T12647 mark while,targeted
R8354 T12647 T12631 advcl targeted,directed
R8355 T12648 T12647 nsubjpass expression,targeted
R8356 T12649 T12648 prep of,expression
R8357 T12650 T12651 det the,latter
R8358 T12651 T12649 pobj latter,of
R8359 T12652 T12647 auxpass is,targeted
R8360 T12653 T12647 prep to,targeted
R8361 T12654 T12655 det the,processes
R8362 T12655 T12653 pobj processes,to
R8363 T12656 T12655 amod axonal,processes
R8364 T12657 T12658 punct [,68
R8365 T12658 T12647 parataxis 68,targeted
R8366 T12659 T12658 nummod 67,68
R8367 T12660 T12658 punct ",",68
R8368 T12661 T12658 punct ],68
R8369 T12662 T12631 punct .,directed
R8370 T12664 T12665 amod Transcriptional,analysis
R8371 T12665 T12669 nsubj analysis,detects
R8372 T12666 T12665 nummod 5,analysis
R8373 T12667 T12666 punct ′,5
R8374 T12668 T12665 compound RACE,analysis
R8375 T12670 T12671 det a,fusion
R8376 T12671 T12669 dobj fusion,detects
R8377 T12672 T12671 prep between,fusion
R8378 T12673 T12672 pobj exon,between
R8379 T12674 T12673 nummod 1,exon
R8380 T12675 T12673 cc and,exon
R8381 T12676 T12677 compound β,geo
R8382 T12677 T12673 conj geo,exon
R8383 T12678 T12677 punct -,geo
R8384 T12679 T12669 punct .,detects
R8385 T12681 T12682 punct (,B
R8386 T12682 T12683 meta B,analysis
R8387 T12684 T12682 punct ),B
R8388 T12685 T12683 compound Southern,analysis
R8389 T12686 T12683 prep of,analysis
R8390 T12687 T12688 det the,locus
R8391 T12688 T12686 pobj locus,of
R8392 T12689 T12688 compound RanBP2,locus
R8393 T12690 T12688 prep of,locus
R8394 T12691 T12692 amod wild,type
R8395 T12692 T12694 nmod type,DNA
R8396 T12693 T12692 punct -,type
R8397 T12694 T12690 pobj DNA,of
R8398 T12695 T12692 cc and,type
R8399 T12696 T12692 conj heterozygous,type
R8400 T12697 T12694 amod genomic,DNA
R8401 T12698 T12694 prep of,DNA
R8402 T12699 T12698 pobj tails,of
R8403 T12700 T12699 prep of,tails
R8404 T12701 T12702 compound F1,mice
R8405 T12702 T12700 pobj mice,of
R8406 T12703 T12702 acl digested,mice
R8407 T12704 T12703 prep with,digested
R8408 T12705 T12704 pobj PpuMI,with
R8409 T12706 T12707 punct (,panel
R8410 T12707 T12705 parataxis panel,PpuMI
R8411 T12708 T12707 amod left,panel
R8412 T12709 T12707 punct ),panel
R8413 T12710 T12705 cc and,PpuMI
R8414 T12711 T12705 conj HindIII,PpuMI
R8415 T12712 T12713 punct (,panel
R8416 T12713 T12711 parataxis panel,HindIII
R8417 T12714 T12713 amod right,panel
R8418 T12715 T12713 punct ),panel
R8419 T12716 T12703 prep with,digested
R8420 T12717 T12716 pobj probes,with
R8421 T12718 T12717 prep at,probes
R8422 T12719 T12720 det the,regions
R8423 T12720 T12718 pobj regions,at
R8424 T12721 T12720 nummod 3,regions
R8425 T12722 T12721 punct ′,3
R8426 T12723 T12724 punct (,panel
R8427 T12724 T12721 parataxis panel,3
R8428 T12725 T12724 amod left,panel
R8429 T12726 T12724 punct ),panel
R8430 T12727 T12721 cc and,3
R8431 T12728 T12721 conj 5,3
R8432 T12729 T12728 punct ′,5
R8433 T12730 T12731 punct (,panel
R8434 T12731 T12728 parataxis panel,5
R8435 T12732 T12731 amod right,panel
R8436 T12733 T12731 punct ),panel
R8437 T12734 T12720 compound flanking,regions
R8438 T12735 T12720 prep of,regions
R8439 T12736 T12737 det the,breakpoint
R8440 T12737 T12735 pobj breakpoint,of
R8441 T12738 T12737 compound insertion,breakpoint
R8442 T12739 T12683 punct .,analysis
R8443 T12741 T12742 nsubj Q1,is
R8444 T12743 T12744 det a,cosmid
R8445 T12744 T12742 attr cosmid,is
R8446 T12745 T12744 acl containing,cosmid
R8447 T12746 T12747 det the,gene
R8448 T12747 T12745 dobj gene,containing
R8449 T12748 T12747 compound RanBP2,gene
R8450 T12749 T12745 prep up,containing
R8451 T12750 T12749 prep to,up
R8452 T12751 T12750 pobj exon,to
R8453 T12752 T12751 nummod 20,exon
R8454 T12753 T12754 punct [,4
R8455 T12754 T12745 parataxis 4,containing
R8456 T12755 T12754 punct ],4
R8457 T12756 T12742 punct .,is
R8458 T12758 T12759 punct (,C
R8459 T12759 T12760 meta C,view
R8460 T12761 T12759 punct ),C
R8461 T12762 T12760 amod Lateroventral,view
R8462 T12763 T12760 prep of,view
R8463 T12764 T12765 det a,stain
R8464 T12765 T12763 pobj stain,of
R8465 T12766 T12767 amod whole,mount
R8466 T12767 T12765 compound mount,stain
R8467 T12768 T12767 punct -,mount
R8468 T12769 T12765 prep of,stain
R8469 T12770 T12771 det a,embryo
R8470 T12771 T12769 pobj embryo,of
R8471 T12772 T12773 punct ~,12.5
R8472 T12773 T12774 nummod 12.5,dpc
R8473 T12774 T12771 nmod dpc,embryo
R8474 T12775 T12771 amod heterozygous,embryo
R8475 T12776 T12765 prep for,stain
R8476 T12777 T12778 nmod PLAP,activities
R8477 T12778 T12776 pobj activities,for
R8478 T12779 T12777 cc and,PLAP
R8479 T12780 T12781 compound β,gal
R8480 T12781 T12777 conj gal,PLAP
R8481 T12782 T12781 punct -,gal
R8482 T12783 T12784 punct (,picture
R8483 T12784 T12781 parataxis picture,gal
R8484 T12785 T12784 compound inset,picture
R8485 T12786 T12784 punct ),picture
R8486 T12787 T12760 punct .,view
R8487 T12789 T12790 mark Although,expressed
R8488 T12790 T12794 advcl expressed,was
R8489 T12791 T12790 nsubjpass PLAP,expressed
R8490 T12792 T12790 auxpass was,expressed
R8491 T12793 T12790 advmod broadly,expressed
R8492 T12795 T12790 punct (,expressed
R8493 T12796 T12797 advmod e.g.,somites
R8494 T12797 T12790 npadvmod somites,expressed
R8495 T12798 T12797 punct ", ",somites
R8496 T12799 T12797 punct ", ",somites
R8497 T12800 T12797 conj limbs,somites
R8498 T12801 T12800 punct ", ",limbs
R8499 T12802 T12800 cc and,limbs
R8500 T12803 T12800 conj CNS,limbs
R8501 T12804 T12794 punct ),was
R8502 T12805 T12794 punct ", ",was
R8503 T12806 T12807 det the,expression
R8504 T12807 T12794 nsubj expression,was
R8505 T12808 T12807 nmod PLAP,expression
R8506 T12809 T12808 cc and,PLAP
R8507 T12810 T12811 compound β,Gal
R8508 T12811 T12808 conj Gal,PLAP
R8509 T12812 T12811 punct -,Gal
R8510 T12813 T12814 punct (,picture
R8511 T12814 T12811 parataxis picture,Gal
R8512 T12815 T12814 compound inset,picture
R8513 T12816 T12814 punct ),picture
R8514 T12817 T12818 advmod particularly,high
R8515 T12818 T12794 acomp high,was
R8516 T12819 T12794 prep in,was
R8517 T12820 T12821 det the,vesicle
R8518 T12821 T12819 pobj vesicle,in
R8519 T12822 T12821 amod optic,vesicle
R8520 T12823 T12824 punct (,arrow
R8521 T12824 T12794 parataxis arrow,was
R8522 T12825 T12824 punct ),arrow
R8523 T12826 T12794 punct .,was
R8524 T12828 T12829 nmod X,gal
R8525 T12829 T12831 nmod gal,staining
R8526 T12830 T12829 punct -,gal
R8527 T12832 T12831 amod single,staining
R8528 T12833 T12834 punct (,D
R8529 T12834 T12832 parataxis D,single
R8530 T12835 T12834 punct ),D
R8531 T12836 T12832 cc and,single
R8532 T12837 T12832 conj combined,single
R8533 T12838 T12831 prep with,staining
R8534 T12839 T12838 pobj PLAP,with
R8535 T12840 T12841 punct (,E
R8536 T12841 T12839 parataxis E,PLAP
R8537 T12842 T12841 punct ),E
R8538 T12843 T12831 prep of,staining
R8539 T12844 T12845 det a,section
R8540 T12845 T12843 pobj section,of
R8541 T12846 T12845 amod retinal,section
R8542 T12847 T12845 prep of,section
R8543 T12848 T12849 det a,mouse
R8544 T12849 T12847 pobj mouse,of
R8545 T12850 T12851 nummod 3,mo
R8546 T12851 T12853 npadvmod mo,old
R8547 T12852 T12851 punct -,mo
R8548 T12853 T12849 amod old,mouse
R8549 T12854 T12853 punct -,old
R8550 T12855 T12849 nmod RanBP2,mouse
R8551 T12856 T12855 punct +,RanBP2
R8552 T12857 T12855 punct /,RanBP2
R8553 T12858 T12855 punct −,RanBP2
R8554 T12859 T12831 punct .,staining
R8555 T12861 T12862 advcl Consistent,detected
R8556 T12863 T12861 prep with,Consistent
R8557 T12864 T12865 amod previous,studies
R8558 T12865 T12863 pobj studies,with
R8559 T12866 T12865 compound immunocytochemistry,studies
R8560 T12867 T12862 punct ", ",detected
R8561 T12868 T12869 compound β,Gal
R8562 T12869 T12871 compound Gal,activity
R8563 T12870 T12869 punct -,Gal
R8564 T12871 T12862 nsubjpass activity,detected
R8565 T12872 T12862 auxpass is,detected
R8566 T12873 T12862 prep in,detected
R8567 T12874 T12875 det the,bodies
R8568 T12875 T12873 pobj bodies,in
R8569 T12876 T12875 amod neuroretinal,bodies
R8570 T12877 T12875 cc and,bodies
R8571 T12878 T12879 amod inner,compartment
R8572 T12879 T12875 conj compartment,bodies
R8573 T12880 T12879 compound segment,compartment
R8574 T12881 T12875 prep of,bodies
R8575 T12882 T12881 pobj photoreceptors,of
R8576 T12883 T12882 prep with,photoreceptors
R8577 T12884 T12885 advmod conspicuously,strong
R8578 T12885 T12886 amod strong,expression
R8579 T12886 T12883 pobj expression,with
R8580 T12887 T12886 prep in,expression
R8581 T12888 T12889 compound ganglion,cells
R8582 T12889 T12887 pobj cells,in
R8583 T12890 T12862 punct .,detected
R8584 T12892 T12893 compound PLAP,expression
R8585 T12893 T12894 nsubjpass expression,found
R8586 T12895 T12894 auxpass is,found
R8587 T12896 T12894 prep throughout,found
R8588 T12897 T12898 det the,layers
R8589 T12898 T12896 pobj layers,throughout
R8590 T12899 T12900 amod plexiform,synaptic
R8591 T12900 T12898 amod synaptic,layers
R8592 T12901 T12900 punct /,synaptic
R8593 T12902 T12898 cc and,layers
R8594 T12903 T12904 amod outer,segment
R8595 T12904 T12898 conj segment,layers
R8596 T12905 T12904 prep of,segment
R8597 T12906 T12905 pobj photoreceptors,of
R8598 T12907 T12908 punct (,E
R8599 T12908 T12894 parataxis E,found
R8600 T12909 T12908 punct ),E
R8601 T12910 T12894 punct .,found
R8602 T12913 T12912 punct ", ",GC
R8603 T12914 T12915 compound ganglion,cell
R8604 T12915 T12912 appos cell,GC
R8605 T12916 T12912 punct ;,GC
R8606 T12917 T12912 appos PLAP,GC
R8607 T12918 T12917 punct ", ",PLAP
R8608 T12919 T12920 amod human,phophatase
R8609 T12920 T12917 appos phophatase,PLAP
R8610 T12921 T12920 amod placental,phophatase
R8611 T12922 T12920 compound alkaline,phophatase
R8612 T12923 T12912 punct ;,GC
R8613 T12924 T12912 appos ROS,GC
R8614 T12925 T12924 punct ", ",ROS
R8615 T12926 T12927 nmod rod,segment
R8616 T12927 T12924 appos segment,ROS
R8617 T12928 T12927 amod outer,segment
R8618 T12929 T12912 punct ;,GC
R8619 T12930 T12912 appos RIS,GC
R8620 T12931 T12930 punct ", ",RIS
R8621 T12932 T12933 nmod rod,segment
R8622 T12933 T12930 appos segment,RIS
R8623 T12934 T12933 amod inner,segment
R8624 T12935 T12912 punct ;,GC
R8625 T12936 T12912 appos ONL,GC
R8626 T12937 T12936 punct ", ",ONL
R8627 T12938 T12939 amod outer,layer
R8628 T12939 T12936 appos layer,ONL
R8629 T12940 T12939 amod nuclear,layer
R8630 T12941 T12912 punct ;,GC
R8631 T12942 T12912 appos OPL,GC
R8632 T12943 T12942 punct ", ",OPL
R8633 T12944 T12945 amod outer,layer
R8634 T12945 T12942 appos layer,OPL
R8635 T12946 T12945 amod plexiform,layer
R8636 T12947 T12945 punct (,layer
R8637 T12948 T12945 amod synaptic,layer
R8638 T12949 T12945 punct ),layer
R8639 T12950 T12912 punct ;,GC
R8640 T12951 T12912 appos INL,GC
R8641 T12952 T12951 punct ", ",INL
R8642 T12953 T12954 amod inner,layer
R8643 T12954 T12951 appos layer,INL
R8644 T12955 T12954 amod nuclear,layer
R8645 T12956 T12912 punct ;,GC
R8646 T12957 T12912 appos IPL,GC
R8647 T12958 T12957 punct ", ",IPL
R8648 T12959 T12960 amod inner,layer
R8649 T12960 T12957 appos layer,IPL
R8650 T12961 T12960 amod plexiform,layer
R8651 T12962 T12960 punct (,layer
R8652 T12963 T12960 amod synaptic,layer
R8653 T12964 T12960 punct ),layer
R8654 T12965 T12912 punct ;,GC
R8655 T12966 T12912 appos GC,GC
R8656 T12967 T12966 punct ", ",GC
R8657 T12968 T12969 compound ganglion,cell
R8658 T12969 T12970 compound cell,layer
R8659 T12970 T12966 appos layer,GC
R8660 T12971 T12912 punct .,GC
R2210 T3641 T3642 prep In,probed
R2211 T3643 T3641 pobj light,In
R2212 T3644 T3643 prep of,light
R2213 T3645 T3646 det the,association
R2214 T3646 T3644 pobj association,of
R2215 T3647 T3648 advmod in,vivo
R2216 T3648 T3646 advmod vivo,association
R2217 T3649 T3646 prep of,association
R2218 T3650 T3649 pobj RanBP2,of
R2219 T3651 T3646 prep with,association
R2220 T3652 T3651 pobj Cox11,with
R2221 T3653 T3652 cc and,Cox11
R2222 T3654 T3652 conj HKI,Cox11
R2223 T3655 T3656 punct (,1
R2224 T3656 T3646 parataxis 1,association
R2225 T3657 T3656 nmod Figures,1
R2226 T3658 T3656 cc and,1
R2227 T3659 T3656 conj 3,1
R2228 T3660 T3656 punct ),1
R2229 T3661 T3646 punct ", ",association
R2230 T3662 T3663 amod profound,modulation
R2231 T3663 T3646 conj modulation,association
R2232 T3664 T3665 advmod in,vitro
R2233 T3665 T3663 amod vitro,modulation
R2234 T3666 T3663 prep of,modulation
R2235 T3667 T3668 npadvmod HKI,enzymatic
R2236 T3668 T3669 amod enzymatic,activity

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12417 11-20 SO_EXT:sequence_insertion_entity_or_process denotes Insertion
T12418 21-32 SO_EXT:sequence_alteration_process denotes Mutagenesis
T12419 40-46 NCBITaxon:39107 denotes Murine
T12420 47-53 PR_EXT:000013712 denotes RanBP2
T12421 54-58 SO_EXT:0000704 denotes Gene
T12422 78-85 SO_EXT:0001026 denotes genomic
T12423 96-102 PR_EXT:000013712 denotes RanBP2
T12424 116-125 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T12425 131-142 SO_EXT:sequence_alteration_process denotes mutagenesis
T12426 150-161 SO:0000879 denotes bicistronic
T12427 171-177 SO_EXT:0000440 denotes vector
T12428 186-190 SO_EXT:0000147 denotes exon
T12429 204-226 SO_EXT:0000079 denotes bicistronic transcript
T12430 240-248 CHEBI_PR_EXT:protein denotes proteins
T12431 255-265 GO:0065007 denotes regulation
T12432 269-275 PR_EXT:000013712 denotes RanBP2
T12433 282-290 GO:0008380 denotes splicing
T12434 294-300 PR_EXT:000013712 denotes RanBP2
T12435 304-310 SO_EXT:sequence_fusion_entity_or_process denotes fusion
T12436 319-323 SO_EXT:0000147 denotes exon
T12437 330-335 GO_EXT:beta_geo denotes β-geo
T12438 339-345 SO_EXT:sequence_fusion_entity_or_process denotes fusion
T12439 358-363 GO_EXT:0004565 denotes β-gal
T12440 368-371 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T12441 372-377 SO_EXT:0000704 denotes genes
T12442 399-404 NCBITaxon:9606 denotes human
T12443 405-414 UBERON:0001987 denotes placental
T12444 405-434 PR_EXT:000003969 denotes placental alkaline phophatase
T12445 415-434 GO_PR_EXT:alkaline_phosphatase denotes alkaline phophatase
T12446 436-440 PR_EXT:000003969 denotes PLAP
T12447 459-469 GO:0006412 denotes translated
T12448 480-508 SO_EXT:0000243 denotes internal ribosome entry site
T12449 489-497 GO:0005840 denotes ribosome
T12450 548-558 GO:0010467 denotes expression
T12451 576-584 GO_EXT:biological_direction_or_guidance denotes directed
T12452 588-592 CL_GO_EXT:cell denotes cell
T12453 588-599 GO:0044297 denotes cell bodies
T12454 607-617 GO:0010467 denotes expression
T12455 635-643 GO_EXT:biological_routing_or_transport denotes targeted
T12456 651-667 GO:0030424 denotes axonal processes
T12457 677-692 GO_EXT:transcription denotes Transcriptional
T12458 720-726 SO_EXT:sequence_fusion_entity_or_process denotes fusion
T12459 735-739 SO_EXT:0000147 denotes exon
T12460 746-751 GO_EXT:beta_geo denotes β-geo
T12461 782-788 PR_EXT:000013712 denotes RanBP2
T12462 798-807 SO_EXT:wild_type_entity_or_quality denotes wild-type
T12463 825-836 SO_EXT:genomic_DNA denotes genomic DNA
T12464 833-836 CHEBI_SO_EXT:DNA denotes DNA
T12465 840-845 UBERON:0002415 denotes tails
T12466 852-856 NCBITaxon:10088 denotes mice
T12467 894-901 PR_EXT:P43870 denotes HindIII
T12468 921-927 CHEBI_SO_EXT:molecular_probe denotes probes
T12469 935-937 _FRAGMENT denotes 3′
T12470 972-988 SO_EXT:0001417 denotes flanking regions
T12471 955-957 _FRAGMENT denotes 5′
T12472 972-988 SO_EXT:0001416 denotes flanking regions
T12473 996-1016 SO_EXT:0001414 denotes insertion breakpoint
T12474 1026-1032 SO_EXT:0000156 denotes cosmid
T12475 1048-1054 PR_EXT:000013712 denotes RanBP2
T12476 1055-1059 SO_EXT:0000704 denotes gene
T12477 1066-1070 SO_EXT:0000147 denotes exon
T12478 1153-1159 UBERON:0000922 denotes embryo
T12479 1164-1168 PR_EXT:000003969 denotes PLAP
T12480 1173-1178 GO_EXT:0004565 denotes β-gal
T12481 1216-1220 PR_EXT:000003969 denotes PLAP
T12482 1233-1242 GO:0010467 denotes expressed
T12483 1250-1257 UBERON:0002329 denotes somites
T12484 1259-1264 UBERON:0002101 denotes limbs
T12485 1270-1273 UBERON:0001017 denotes CNS
T12486 1280-1284 PR_EXT:000003969 denotes PLAP
T12487 1289-1294 GO_EXT:0004565 denotes β-Gal
T12488 1311-1321 GO:0010467 denotes expression
T12489 1351-1364 UBERON:0004128 denotes optic vesicle
T12490 1374-1379 CHEBI:75055 denotes X-gal
T12491 1418-1422 PR_EXT:000003969 denotes PLAP
T12492 1432-1439 UBERON:0000966 denotes retinal
T12493 1462-1468 PR_EXT:000013712 denotes RanBP2
T12494 1468-1469 SO_EXT:normal_or_wild_type_or_present denotes +
T12495 1470-1471 SO_EXT:sequence_nullness_or_absence denotes −
T12496 1472-1477 NCBITaxon:10088 denotes mouse
T12497 1533-1538 GO_EXT:0004565 denotes β-Gal
T12498 1567-1579 UBERON:0001781 denotes neuroretinal
T12499 1591-1604 GO:0001917 denotes inner segment
T12500 1620-1634 CL:0000210 denotes photoreceptors
T12501 1661-1671 GO:0010467 denotes expression
T12502 1675-1683 UBERON:0000045 denotes ganglion
T12503 1675-1689 CL:0000740 denotes ganglion cells
T12504 1684-1689 CL_GO_EXT:cell denotes cells
T12505 1691-1695 PR_EXT:000003969 denotes PLAP
T12506 1696-1706 GO:0010467 denotes expression
T12507 1741-1749 GO:0045202 denotes synaptic
T12508 1761-1792 GO:0001750 denotes outer segment of photoreceptors
T12509 1778-1792 CL:0000210 denotes photoreceptors
T12510 1798-1800 CL:0000740 denotes GC
T12511 1802-1810 UBERON:0000045 denotes ganglion
T12512 1802-1815 CL:0000740 denotes ganglion cell
T12513 1811-1815 CL_GO_EXT:cell denotes cell
T12514 1817-1821 PR_EXT:000003969 denotes PLAP
T12515 1823-1828 NCBITaxon:9606 denotes human
T12516 1829-1838 UBERON:0001987 denotes placental
T12517 1829-1858 PR_EXT:000003969 denotes placental alkaline phophatase
T12518 1839-1858 GO_PR_EXT:alkaline_phosphatase denotes alkaline phophatase
T12519 1865-1868 CL:0000604 denotes rod
T12520 1869-1882 GO:0001750 denotes outer segment
T12521 1889-1892 CL:0000604 denotes rod
T12522 1893-1906 GO:0001917 denotes inner segment
T12523 1908-1911 UBERON:0001789 denotes ONL
T12524 1913-1932 UBERON:0001789 denotes outer nuclear layer
T12525 1919-1926 GO:0005634 denotes nuclear
T12526 1956-1964 GO:0045202 denotes synaptic
T12527 1973-1976 UBERON:0001791 denotes INL
T12528 1978-1997 UBERON:0001791 denotes inner nuclear layer
T12529 1984-1991 GO:0005634 denotes nuclear
T12530 2021-2029 GO:0045202 denotes synaptic
T12531 2038-2040 UBERON:0001792 denotes GC
T12532 2042-2055 CL:0000740 denotes ganglion cell
T12533 2042-2061 UBERON:0001792 denotes ganglion cell layer
T12534 2051-2055 CL_GO_EXT:cell denotes cell
T3373 2102-2108 PR_EXT:000013712 denotes RanBP2
T3374 2114-2119 PR_EXT:000005770 denotes Cox11
T3375 2124-2127 PR_EXT:000008608 denotes HKI
T3376 2165-2175 GO:0065007 denotes modulation
T3377 2179-2182 PR_EXT:000008608 denotes HKI
T3378 2183-2192 CHEBI_GO_SO_EXT:enzyme denotes enzymatic
T3379 2205-2211 PR_EXT:000013712 denotes RanBP2
T3380 2216-2221 PR_EXT:000005770 denotes Cox11
T3381 2259-2262 PR_EXT:000008608 denotes HKI
T3382 2266-2276 GO_MOP_EXT:catalysis denotes catalyzing
T3383 2301-2311 GO:0006096 denotes glycolysis
T3384 2331-2337 PR_EXT:000013712 denotes RanBP2
T3385 2337-2338 SO_EXT:normal_or_wild_type_or_present denotes +
T3386 2339-2340 SO_EXT:sequence_nullness_or_absence denotes −
T3387 2341-2345 NCBITaxon:10088 denotes mice
T3388 2372-2375 PR_EXT:000008608 denotes HKI
T3389 2377-2382 PR_EXT:000005770 denotes Cox11
T3390 2388-2406 GO:0097009 denotes energy homeostasis
R8249 T12470 T12469 _lexicallyChainedTo flanking regions,3′
R8250 T12472 T12471 _lexicallyChainedTo flanking regions,5′

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12328 40-46 NCBITaxon:39107 denotes Murine
T12329 47-53 PR:000013712 denotes RanBP2
T12330 54-58 SO:0000704 denotes Gene
T12331 78-85 SO:0001026 denotes genomic
T12332 96-102 PR:000013712 denotes RanBP2
T12333 150-161 SO:0000879 denotes bicistronic
T12334 171-177 SO:0000440 denotes vector
T12335 186-190 SO:0000147 denotes exon
T12336 204-226 SO:0000079 denotes bicistronic transcript
T12337 255-265 GO:0065007 denotes regulation
T12338 269-275 PR:000013712 denotes RanBP2
T12339 282-290 GO:0008380 denotes splicing
T12340 294-300 PR:000013712 denotes RanBP2
T12341 319-323 SO:0000147 denotes exon
T12342 372-377 SO:0000704 denotes genes
T12343 399-404 NCBITaxon:9606 denotes human
T12344 405-414 UBERON:0001987 denotes placental
T12345 405-434 PR:000003969 denotes placental alkaline phophatase
T12346 436-440 PR:000003969 denotes PLAP
T12347 459-469 GO:0006412 denotes translated
T12348 480-508 SO:0000243 denotes internal ribosome entry site
T12349 489-497 GO:0005840 denotes ribosome
T12350 548-558 GO:0010467 denotes expression
T12351 588-599 GO:0044297 denotes cell bodies
T12352 607-617 GO:0010467 denotes expression
T12353 651-667 GO:0030424 denotes axonal processes
T12354 735-739 SO:0000147 denotes exon
T12355 782-788 PR:000013712 denotes RanBP2
T12356 825-832 SO:0001026 denotes genomic
T12357 840-845 UBERON:0002415 denotes tails
T12358 852-856 NCBITaxon:10088 denotes mice
T12359 894-901 PR:P43870 denotes HindIII
T12360 935-937 _FRAGMENT denotes 3′
T12361 972-988 SO:0001417 denotes flanking regions
T12362 955-957 _FRAGMENT denotes 5′
T12363 972-988 SO:0001416 denotes flanking regions
T12364 996-1016 SO:0001414 denotes insertion breakpoint
T12365 1026-1032 SO:0000156 denotes cosmid
T12366 1048-1054 PR:000013712 denotes RanBP2
T12367 1055-1059 SO:0000704 denotes gene
T12368 1066-1070 SO:0000147 denotes exon
T12369 1153-1159 UBERON:0000922 denotes embryo
T12370 1164-1168 PR:000003969 denotes PLAP
T12371 1216-1220 PR:000003969 denotes PLAP
T12372 1233-1242 GO:0010467 denotes expressed
T12373 1250-1257 UBERON:0002329 denotes somites
T12374 1259-1264 UBERON:0002101 denotes limbs
T12375 1270-1273 UBERON:0001017 denotes CNS
T12376 1280-1284 PR:000003969 denotes PLAP
T12377 1311-1321 GO:0010467 denotes expression
T12378 1351-1364 UBERON:0004128 denotes optic vesicle
T12379 1374-1379 CHEBI:75055 denotes X-gal
T12380 1418-1422 PR:000003969 denotes PLAP
T12381 1432-1439 UBERON:0000966 denotes retinal
T12382 1462-1468 PR:000013712 denotes RanBP2
T12383 1472-1477 NCBITaxon:10088 denotes mouse
T12384 1567-1579 UBERON:0001781 denotes neuroretinal
T12385 1591-1604 GO:0001917 denotes inner segment
T12386 1620-1634 CL:0000210 denotes photoreceptors
T12387 1661-1671 GO:0010467 denotes expression
T12388 1675-1683 UBERON:0000045 denotes ganglion
T12389 1675-1689 CL:0000740 denotes ganglion cells
T12390 1691-1695 PR:000003969 denotes PLAP
T12391 1696-1706 GO:0010467 denotes expression
T12392 1741-1749 GO:0045202 denotes synaptic
T12393 1761-1792 GO:0001750 denotes outer segment of photoreceptors
T12394 1778-1792 CL:0000210 denotes photoreceptors
T12395 1798-1800 CL:0000740 denotes GC
T12396 1802-1810 UBERON:0000045 denotes ganglion
T12397 1802-1815 CL:0000740 denotes ganglion cell
T12398 1817-1821 PR:000003969 denotes PLAP
T12399 1823-1828 NCBITaxon:9606 denotes human
T12400 1829-1838 UBERON:0001987 denotes placental
T12401 1829-1858 PR:000003969 denotes placental alkaline phophatase
T12402 1865-1868 CL:0000604 denotes rod
T12403 1869-1882 GO:0001750 denotes outer segment
T12404 1889-1892 CL:0000604 denotes rod
T12405 1893-1906 GO:0001917 denotes inner segment
T12406 1908-1911 UBERON:0001789 denotes ONL
T12407 1913-1932 UBERON:0001789 denotes outer nuclear layer
T12408 1919-1926 GO:0005634 denotes nuclear
T12409 1956-1964 GO:0045202 denotes synaptic
T12410 1973-1976 UBERON:0001791 denotes INL
T12411 1978-1997 UBERON:0001791 denotes inner nuclear layer
T12412 1984-1991 GO:0005634 denotes nuclear
T12413 2021-2029 GO:0045202 denotes synaptic
T12414 2038-2040 UBERON:0001792 denotes GC
T12415 2042-2055 CL:0000740 denotes ganglion cell
T12416 2042-2061 UBERON:0001792 denotes ganglion cell layer
T3278 2341-2345 NCBITaxon:10088 denotes mice
T3279 2372-2375 PR:000008608 denotes HKI
T3280 2377-2382 PR:000005770 denotes Cox11
T3281 2388-2406 GO:0097009 denotes energy homeostasis
T3268 2102-2108 PR:000013712 denotes RanBP2
T3269 2114-2119 PR:000005770 denotes Cox11
T3270 2124-2127 PR:000008608 denotes HKI
T3271 2165-2175 GO:0065007 denotes modulation
T3272 2179-2182 PR:000008608 denotes HKI
T3273 2205-2211 PR:000013712 denotes RanBP2
T3274 2216-2221 PR:000005770 denotes Cox11
T3275 2259-2262 PR:000008608 denotes HKI
T3276 2301-2311 GO:0006096 denotes glycolysis
T3277 2331-2337 PR:000013712 denotes RanBP2
R8247 T12361 T12360 _lexicallyChainedTo flanking regions,3′
R8248 T12363 T12362 _lexicallyChainedTo flanking regions,5′

2_test

Id Subject Object Predicate Lexical cue
17069463-11075368-85858834 669-671 11075368 denotes 67
17069463-11242070-85858835 672-674 11242070 denotes 68
17069463-11353387-85858836 1075-1076 11353387 denotes 4
T32843 669-671 11075368 denotes 67
T51336 672-674 11242070 denotes 68
T26529 1075-1076 11353387 denotes 4