Id |
Subject |
Object |
Predicate |
Lexical cue |
T2655 |
0-2 |
TO |
denotes |
To |
T2656 |
3-8 |
VB |
denotes |
probe |
T2657 |
122-130 |
VBD |
denotes |
examined |
T2658 |
9-16 |
IN |
denotes |
whether |
T2659 |
72-81 |
VBZ |
denotes |
modulates |
T2660 |
17-20 |
DT |
denotes |
the |
T2661 |
21-32 |
NN |
denotes |
interaction |
T2662 |
33-35 |
IN |
denotes |
of |
T2663 |
36-41 |
NN |
denotes |
Cox11 |
T2664 |
42-45 |
CC |
denotes |
and |
T2665 |
46-49 |
NN |
denotes |
HKI |
T2666 |
50-54 |
IN |
denotes |
with |
T2667 |
55-58 |
DT |
denotes |
the |
T2668 |
59-61 |
NN |
denotes |
LD |
T2669 |
62-64 |
IN |
denotes |
of |
T2670 |
65-71 |
NN |
denotes |
RanBP2 |
T2671 |
82-85 |
DT |
denotes |
the |
T2672 |
96-104 |
NN |
denotes |
activity |
T2673 |
86-95 |
JJ |
denotes |
enzymatic |
T2674 |
105-107 |
IN |
denotes |
of |
T2675 |
108-111 |
NN |
denotes |
HKI |
T2676 |
111-113 |
, |
denotes |
, |
T2677 |
113-115 |
PRP |
denotes |
we |
T2678 |
116-121 |
RB |
denotes |
first |
T2679 |
131-134 |
DT |
denotes |
the |
T2680 |
135-141 |
NN |
denotes |
effect |
T2681 |
142-144 |
IN |
denotes |
of |
T2682 |
145-155 |
VBG |
denotes |
increasing |
T2683 |
156-170 |
NNS |
denotes |
concentrations |
T2684 |
171-173 |
IN |
denotes |
of |
T2685 |
174-179 |
NN |
denotes |
Cox11 |
T2686 |
180-182 |
IN |
denotes |
on |
T2687 |
183-186 |
DT |
denotes |
the |
T2688 |
195-200 |
NNS |
denotes |
rates |
T2689 |
187-194 |
JJ |
denotes |
initial |
T2690 |
201-203 |
IN |
denotes |
of |
T2691 |
204-207 |
NN |
denotes |
HKI |
T2692 |
218-226 |
NN |
denotes |
activity |
T2693 |
208-217 |
JJ |
denotes |
enzymatic |
T2694 |
227-228 |
-LRB- |
denotes |
( |
T2695 |
235-237 |
NN |
denotes |
2A |
T2696 |
228-234 |
NN |
denotes |
Figure |
T2697 |
237-238 |
-RRB- |
denotes |
) |
T2698 |
238-239 |
. |
denotes |
. |
T2699 |
239-386 |
sentence |
denotes |
Cox11 strongly inhibits HKI activity in a concentration-dependent fashion, and at ~15 nM of Cox11, HKI activity could not be recorded (Figure 2A). |
T2700 |
240-245 |
NN |
denotes |
Cox11 |
T2701 |
255-263 |
VBZ |
denotes |
inhibits |
T2702 |
246-254 |
RB |
denotes |
strongly |
T2703 |
264-267 |
NN |
denotes |
HKI |
T2704 |
268-276 |
NN |
denotes |
activity |
T2705 |
277-279 |
IN |
denotes |
in |
T2706 |
280-281 |
DT |
denotes |
a |
T2707 |
306-313 |
NN |
denotes |
fashion |
T2708 |
282-295 |
NN |
denotes |
concentration |
T2709 |
296-305 |
JJ |
denotes |
dependent |
T2710 |
295-296 |
HYPH |
denotes |
- |
T2711 |
313-315 |
, |
denotes |
, |
T2712 |
315-318 |
CC |
denotes |
and |
T2713 |
319-321 |
IN |
denotes |
at |
T2714 |
365-373 |
VBN |
denotes |
recorded |
T2715 |
322-323 |
SYM |
denotes |
~ |
T2716 |
323-325 |
CD |
denotes |
15 |
T2717 |
326-328 |
NN |
denotes |
nM |
T2718 |
329-331 |
IN |
denotes |
of |
T2719 |
332-337 |
NN |
denotes |
Cox11 |
T2720 |
337-339 |
, |
denotes |
, |
T2721 |
339-342 |
NN |
denotes |
HKI |
T2722 |
343-351 |
NN |
denotes |
activity |
T2723 |
352-357 |
MD |
denotes |
could |
T2724 |
358-361 |
RB |
denotes |
not |
T2725 |
362-364 |
VB |
denotes |
be |
T2726 |
374-375 |
-LRB- |
denotes |
( |
T2727 |
382-384 |
NN |
denotes |
2A |
T2728 |
375-381 |
NN |
denotes |
Figure |
T2729 |
384-385 |
-RRB- |
denotes |
) |
T2730 |
385-386 |
. |
denotes |
. |
T2731 |
386-500 |
sentence |
denotes |
Cox11 behaves as a partial noncompetitive inhibitor of HKI by affecting the V max of HKI for glucose (Figure 2B). |
T2732 |
387-392 |
NN |
denotes |
Cox11 |
T2733 |
393-400 |
VBZ |
denotes |
behaves |
T2734 |
401-403 |
IN |
denotes |
as |
T2735 |
404-405 |
DT |
denotes |
a |
T2736 |
429-438 |
NN |
denotes |
inhibitor |
T2737 |
406-413 |
JJ |
denotes |
partial |
T2738 |
414-428 |
JJ |
denotes |
noncompetitive |
T2739 |
439-441 |
IN |
denotes |
of |
T2740 |
442-445 |
NN |
denotes |
HKI |
T2741 |
446-448 |
IN |
denotes |
by |
T2742 |
449-458 |
VBG |
denotes |
affecting |
T2743 |
459-462 |
DT |
denotes |
the |
T2744 |
463-468 |
NN |
denotes |
V max |
T2745 |
469-471 |
IN |
denotes |
of |
T2746 |
472-475 |
NN |
denotes |
HKI |
T2747 |
476-479 |
IN |
denotes |
for |
T2748 |
480-487 |
NN |
denotes |
glucose |
T2749 |
488-489 |
-LRB- |
denotes |
( |
T2750 |
496-498 |
NN |
denotes |
2B |
T2751 |
489-495 |
NN |
denotes |
Figure |
T2752 |
498-499 |
-RRB- |
denotes |
) |
T2753 |
499-500 |
. |
denotes |
. |
T2754 |
500-715 |
sentence |
denotes |
Then, we evaluated the effect of the LD of RanBP2 on the HK activity in the presence of a fixed inhibitory concentration of Cox11, saturating concentration of glucose substrate, and increasing concentrations of LD. |
T2755 |
501-505 |
RB |
denotes |
Then |
T2756 |
510-519 |
VBD |
denotes |
evaluated |
T2757 |
505-507 |
, |
denotes |
, |
T2758 |
507-509 |
PRP |
denotes |
we |
T2759 |
520-523 |
DT |
denotes |
the |
T2760 |
524-530 |
NN |
denotes |
effect |
T2761 |
531-533 |
IN |
denotes |
of |
T2762 |
534-537 |
DT |
denotes |
the |
T2763 |
538-540 |
NN |
denotes |
LD |
T2764 |
541-543 |
IN |
denotes |
of |
T2765 |
544-550 |
NN |
denotes |
RanBP2 |
T2766 |
551-553 |
IN |
denotes |
on |
T2767 |
554-557 |
DT |
denotes |
the |
T2768 |
561-569 |
NN |
denotes |
activity |
T2769 |
558-560 |
NN |
denotes |
HK |
T2770 |
570-572 |
IN |
denotes |
in |
T2771 |
573-576 |
DT |
denotes |
the |
T2772 |
577-585 |
NN |
denotes |
presence |
T2773 |
586-588 |
IN |
denotes |
of |
T2774 |
589-590 |
DT |
denotes |
a |
T2775 |
608-621 |
NN |
denotes |
concentration |
T2776 |
591-596 |
VBN |
denotes |
fixed |
T2777 |
597-607 |
JJ |
denotes |
inhibitory |
T2778 |
622-624 |
IN |
denotes |
of |
T2779 |
625-630 |
NN |
denotes |
Cox11 |
T2780 |
630-632 |
, |
denotes |
, |
T2781 |
632-642 |
VBG |
denotes |
saturating |
T2782 |
643-656 |
NN |
denotes |
concentration |
T2783 |
657-659 |
IN |
denotes |
of |
T2784 |
660-667 |
NN |
denotes |
glucose |
T2785 |
668-677 |
NN |
denotes |
substrate |
T2786 |
677-679 |
, |
denotes |
, |
T2787 |
679-682 |
CC |
denotes |
and |
T2788 |
683-693 |
VBG |
denotes |
increasing |
T2789 |
694-708 |
NNS |
denotes |
concentrations |
T2790 |
709-711 |
IN |
denotes |
of |
T2791 |
712-714 |
NN |
denotes |
LD |
T2792 |
714-715 |
. |
denotes |
. |
T2793 |
715-1089 |
sentence |
denotes |
As shown in Figure 2C, the LD domain sharply reversed the inhibitory effect of Cox11 on HKI activity in a concentration-dependent manner, but under saturating (and stochiometric) amounts of LD, the velocity of the reaction did not reach that observed for HKI activity in the absence of Cox11 (Figure 2A), suggesting the LD by itself may also have an effect on HKI activity. |
T2794 |
716-718 |
IN |
denotes |
As |
T2795 |
719-724 |
VBN |
denotes |
shown |
T2796 |
761-769 |
VBD |
denotes |
reversed |
T2797 |
725-727 |
IN |
denotes |
in |
T2798 |
728-734 |
NN |
denotes |
Figure |
T2799 |
735-737 |
NN |
denotes |
2C |
T2800 |
737-739 |
, |
denotes |
, |
T2801 |
739-742 |
DT |
denotes |
the |
T2802 |
746-752 |
NN |
denotes |
domain |
T2803 |
743-745 |
NN |
denotes |
LD |
T2804 |
753-760 |
RB |
denotes |
sharply |
T2805 |
770-773 |
DT |
denotes |
the |
T2806 |
785-791 |
NN |
denotes |
effect |
T2807 |
774-784 |
JJ |
denotes |
inhibitory |
T2808 |
792-794 |
IN |
denotes |
of |
T2809 |
795-800 |
NN |
denotes |
Cox11 |
T2810 |
801-803 |
IN |
denotes |
on |
T2811 |
804-807 |
NN |
denotes |
HKI |
T2812 |
808-816 |
NN |
denotes |
activity |
T2813 |
817-819 |
IN |
denotes |
in |
T2814 |
820-821 |
DT |
denotes |
a |
T2815 |
846-852 |
NN |
denotes |
manner |
T2816 |
822-835 |
NN |
denotes |
concentration |
T2817 |
836-845 |
JJ |
denotes |
dependent |
T2818 |
835-836 |
HYPH |
denotes |
- |
T2819 |
852-854 |
, |
denotes |
, |
T2820 |
854-857 |
CC |
denotes |
but |
T2821 |
858-863 |
IN |
denotes |
under |
T2822 |
947-952 |
VB |
denotes |
reach |
T2823 |
864-874 |
VBG |
denotes |
saturating |
T2824 |
895-902 |
NNS |
denotes |
amounts |
T2825 |
875-876 |
-LRB- |
denotes |
( |
T2826 |
876-879 |
CC |
denotes |
and |
T2827 |
880-893 |
JJ |
denotes |
stochiometric |
T2828 |
893-894 |
-RRB- |
denotes |
) |
T2829 |
903-905 |
IN |
denotes |
of |
T2830 |
906-908 |
NN |
denotes |
LD |
T2831 |
908-910 |
, |
denotes |
, |
T2832 |
910-913 |
DT |
denotes |
the |
T2833 |
914-922 |
NN |
denotes |
velocity |
T2834 |
923-925 |
IN |
denotes |
of |
T2835 |
926-929 |
DT |
denotes |
the |
T2836 |
930-938 |
NN |
denotes |
reaction |
T2837 |
939-942 |
VBD |
denotes |
did |
T2838 |
943-946 |
RB |
denotes |
not |
T2839 |
953-957 |
DT |
denotes |
that |
T2840 |
958-966 |
VBN |
denotes |
observed |
T2841 |
967-970 |
IN |
denotes |
for |
T2842 |
971-974 |
NN |
denotes |
HKI |
T2843 |
975-983 |
NN |
denotes |
activity |
T2844 |
984-986 |
IN |
denotes |
in |
T2845 |
987-990 |
DT |
denotes |
the |
T2846 |
991-998 |
NN |
denotes |
absence |
T2847 |
999-1001 |
IN |
denotes |
of |
T2848 |
1002-1007 |
NN |
denotes |
Cox11 |
T2849 |
1008-1009 |
-LRB- |
denotes |
( |
T2850 |
1016-1018 |
NN |
denotes |
2A |
T2851 |
1009-1015 |
NN |
denotes |
Figure |
T2852 |
1018-1019 |
-RRB- |
denotes |
) |
T2853 |
1019-1021 |
, |
denotes |
, |
T2854 |
1021-1031 |
VBG |
denotes |
suggesting |
T2855 |
1032-1035 |
DT |
denotes |
the |
T2856 |
1036-1038 |
NN |
denotes |
LD |
T2857 |
1058-1062 |
VB |
denotes |
have |
T2858 |
1039-1041 |
IN |
denotes |
by |
T2859 |
1042-1048 |
PRP |
denotes |
itself |
T2860 |
1049-1052 |
MD |
denotes |
may |
T2861 |
1053-1057 |
RB |
denotes |
also |
T2862 |
1063-1065 |
DT |
denotes |
an |
T2863 |
1066-1072 |
NN |
denotes |
effect |
T2864 |
1073-1075 |
IN |
denotes |
on |
T2865 |
1076-1079 |
NN |
denotes |
HKI |
T2866 |
1080-1088 |
NN |
denotes |
activity |
T2867 |
1088-1089 |
. |
denotes |
. |
T2868 |
1089-1217 |
sentence |
denotes |
Indeed, a saturating concentration of LD reduced the V max but not the K m of HKI (Figure 2D) by ~20% under similar conditions. |
T2869 |
1090-1096 |
RB |
denotes |
Indeed |
T2870 |
1131-1138 |
VBD |
denotes |
reduced |
T2871 |
1096-1098 |
, |
denotes |
, |
T2872 |
1098-1099 |
DT |
denotes |
a |
T2873 |
1111-1124 |
NN |
denotes |
concentration |
T2874 |
1100-1110 |
NN |
denotes |
saturating |
T2875 |
1125-1127 |
IN |
denotes |
of |
T2876 |
1128-1130 |
NN |
denotes |
LD |
T2877 |
1139-1142 |
DT |
denotes |
the |
T2878 |
1143-1148 |
NN |
denotes |
V max |
T2879 |
1149-1152 |
CC |
denotes |
but |
T2880 |
1153-1156 |
RB |
denotes |
not |
T2881 |
1157-1160 |
DT |
denotes |
the |
T2882 |
1161-1164 |
NN |
denotes |
K m |
T2883 |
1165-1167 |
IN |
denotes |
of |
T2884 |
1168-1171 |
NN |
denotes |
HKI |
T2885 |
1172-1173 |
-LRB- |
denotes |
( |
T2886 |
1180-1182 |
NN |
denotes |
2D |
T2887 |
1173-1179 |
NN |
denotes |
Figure |
T2888 |
1182-1183 |
-RRB- |
denotes |
) |
T2889 |
1184-1186 |
IN |
denotes |
by |
T2890 |
1187-1188 |
SYM |
denotes |
~ |
T2891 |
1188-1190 |
CD |
denotes |
20 |
T2892 |
1190-1191 |
NN |
denotes |
% |
T2893 |
1192-1197 |
IN |
denotes |
under |
T2894 |
1198-1205 |
JJ |
denotes |
similar |
T2895 |
1206-1216 |
NNS |
denotes |
conditions |
T2896 |
1216-1217 |
. |
denotes |
. |
R1628 |
T2655 |
T2656 |
aux |
To,probe |
R1629 |
T2656 |
T2657 |
advcl |
probe,examined |
R1630 |
T2658 |
T2659 |
mark |
whether,modulates |
R1631 |
T2659 |
T2656 |
ccomp |
modulates,probe |
R1632 |
T2660 |
T2661 |
det |
the,interaction |
R1633 |
T2661 |
T2659 |
nsubj |
interaction,modulates |
R1634 |
T2662 |
T2661 |
prep |
of,interaction |
R1635 |
T2663 |
T2662 |
pobj |
Cox11,of |
R1636 |
T2664 |
T2663 |
cc |
and,Cox11 |
R1637 |
T2665 |
T2663 |
conj |
HKI,Cox11 |
R1638 |
T2666 |
T2661 |
prep |
with,interaction |
R1639 |
T2667 |
T2668 |
det |
the,LD |
R1640 |
T2668 |
T2666 |
pobj |
LD,with |
R1641 |
T2669 |
T2668 |
prep |
of,LD |
R1642 |
T2670 |
T2669 |
pobj |
RanBP2,of |
R1643 |
T2671 |
T2672 |
det |
the,activity |
R1644 |
T2672 |
T2659 |
dobj |
activity,modulates |
R1645 |
T2673 |
T2672 |
amod |
enzymatic,activity |
R1646 |
T2674 |
T2672 |
prep |
of,activity |
R1647 |
T2675 |
T2674 |
pobj |
HKI,of |
R1648 |
T2676 |
T2657 |
punct |
", ",examined |
R1649 |
T2677 |
T2657 |
nsubj |
we,examined |
R1650 |
T2678 |
T2657 |
advmod |
first,examined |
R1651 |
T2679 |
T2680 |
det |
the,effect |
R1652 |
T2680 |
T2657 |
dobj |
effect,examined |
R1653 |
T2681 |
T2680 |
prep |
of,effect |
R1654 |
T2682 |
T2681 |
pcomp |
increasing,of |
R1655 |
T2683 |
T2682 |
dobj |
concentrations,increasing |
R1656 |
T2684 |
T2683 |
prep |
of,concentrations |
R1657 |
T2685 |
T2684 |
pobj |
Cox11,of |
R1658 |
T2686 |
T2680 |
prep |
on,effect |
R1659 |
T2687 |
T2688 |
det |
the,rates |
R1660 |
T2688 |
T2686 |
pobj |
rates,on |
R1661 |
T2689 |
T2688 |
amod |
initial,rates |
R1662 |
T2690 |
T2688 |
prep |
of,rates |
R1663 |
T2691 |
T2692 |
nmod |
HKI,activity |
R1664 |
T2692 |
T2690 |
pobj |
activity,of |
R1665 |
T2693 |
T2692 |
amod |
enzymatic,activity |
R1666 |
T2694 |
T2695 |
punct |
(,2A |
R1667 |
T2695 |
T2657 |
parataxis |
2A,examined |
R1668 |
T2696 |
T2695 |
compound |
Figure,2A |
R1669 |
T2697 |
T2695 |
punct |
),2A |
R1670 |
T2698 |
T2657 |
punct |
.,examined |
R1671 |
T2700 |
T2701 |
nsubj |
Cox11,inhibits |
R1672 |
T2702 |
T2701 |
advmod |
strongly,inhibits |
R1673 |
T2703 |
T2704 |
compound |
HKI,activity |
R1674 |
T2704 |
T2701 |
dobj |
activity,inhibits |
R1675 |
T2705 |
T2701 |
prep |
in,inhibits |
R1676 |
T2706 |
T2707 |
det |
a,fashion |
R1677 |
T2707 |
T2705 |
pobj |
fashion,in |
R1678 |
T2708 |
T2709 |
npadvmod |
concentration,dependent |
R1679 |
T2709 |
T2707 |
amod |
dependent,fashion |
R1680 |
T2710 |
T2709 |
punct |
-,dependent |
R1681 |
T2711 |
T2701 |
punct |
", ",inhibits |
R1682 |
T2712 |
T2701 |
cc |
and,inhibits |
R1683 |
T2713 |
T2714 |
prep |
at,recorded |
R1684 |
T2714 |
T2701 |
conj |
recorded,inhibits |
R1685 |
T2715 |
T2716 |
punct |
~,15 |
R1686 |
T2716 |
T2717 |
nummod |
15,nM |
R1687 |
T2717 |
T2713 |
pobj |
nM,at |
R1688 |
T2718 |
T2717 |
prep |
of,nM |
R1689 |
T2719 |
T2718 |
pobj |
Cox11,of |
R1690 |
T2720 |
T2714 |
punct |
", ",recorded |
R1691 |
T2721 |
T2722 |
compound |
HKI,activity |
R1692 |
T2722 |
T2714 |
nsubjpass |
activity,recorded |
R1693 |
T2723 |
T2714 |
aux |
could,recorded |
R1694 |
T2724 |
T2714 |
neg |
not,recorded |
R1695 |
T2725 |
T2714 |
auxpass |
be,recorded |
R1696 |
T2726 |
T2727 |
punct |
(,2A |
R1697 |
T2727 |
T2714 |
parataxis |
2A,recorded |
R1698 |
T2728 |
T2727 |
compound |
Figure,2A |
R1699 |
T2729 |
T2727 |
punct |
),2A |
R1700 |
T2730 |
T2714 |
punct |
.,recorded |
R1701 |
T2732 |
T2733 |
nsubj |
Cox11,behaves |
R1702 |
T2734 |
T2733 |
prep |
as,behaves |
R1703 |
T2735 |
T2736 |
det |
a,inhibitor |
R1704 |
T2736 |
T2734 |
pobj |
inhibitor,as |
R1705 |
T2737 |
T2736 |
amod |
partial,inhibitor |
R1706 |
T2738 |
T2736 |
amod |
noncompetitive,inhibitor |
R1707 |
T2739 |
T2736 |
prep |
of,inhibitor |
R1708 |
T2740 |
T2739 |
pobj |
HKI,of |
R1709 |
T2741 |
T2733 |
prep |
by,behaves |
R1710 |
T2742 |
T2741 |
pcomp |
affecting,by |
R1711 |
T2743 |
T2744 |
det |
the,V max |
R1712 |
T2744 |
T2742 |
dobj |
V max,affecting |
R1713 |
T2745 |
T2744 |
prep |
of,V max |
R1714 |
T2746 |
T2745 |
pobj |
HKI,of |
R1715 |
T2747 |
T2744 |
prep |
for,V max |
R1716 |
T2748 |
T2747 |
pobj |
glucose,for |
R1717 |
T2749 |
T2750 |
punct |
(,2B |
R1718 |
T2750 |
T2742 |
parataxis |
2B,affecting |
R1719 |
T2751 |
T2750 |
compound |
Figure,2B |
R1720 |
T2752 |
T2750 |
punct |
),2B |
R1721 |
T2753 |
T2733 |
punct |
.,behaves |
R1722 |
T2755 |
T2756 |
advmod |
Then,evaluated |
R1723 |
T2757 |
T2756 |
punct |
", ",evaluated |
R1724 |
T2758 |
T2756 |
nsubj |
we,evaluated |
R1725 |
T2759 |
T2760 |
det |
the,effect |
R1726 |
T2760 |
T2756 |
dobj |
effect,evaluated |
R1727 |
T2761 |
T2760 |
prep |
of,effect |
R1728 |
T2762 |
T2763 |
det |
the,LD |
R1729 |
T2763 |
T2761 |
pobj |
LD,of |
R1730 |
T2764 |
T2763 |
prep |
of,LD |
R1731 |
T2765 |
T2764 |
pobj |
RanBP2,of |
R1732 |
T2766 |
T2760 |
prep |
on,effect |
R1733 |
T2767 |
T2768 |
det |
the,activity |
R1734 |
T2768 |
T2766 |
pobj |
activity,on |
R1735 |
T2769 |
T2768 |
compound |
HK,activity |
R1736 |
T2770 |
T2756 |
prep |
in,evaluated |
R1737 |
T2771 |
T2772 |
det |
the,presence |
R1738 |
T2772 |
T2770 |
pobj |
presence,in |
R1739 |
T2773 |
T2772 |
prep |
of,presence |
R1740 |
T2774 |
T2775 |
det |
a,concentration |
R1741 |
T2775 |
T2773 |
pobj |
concentration,of |
R1742 |
T2776 |
T2775 |
amod |
fixed,concentration |
R1743 |
T2777 |
T2775 |
amod |
inhibitory,concentration |
R1744 |
T2778 |
T2775 |
prep |
of,concentration |
R1745 |
T2779 |
T2778 |
pobj |
Cox11,of |
R1746 |
T2780 |
T2775 |
punct |
", ",concentration |
R1747 |
T2781 |
T2782 |
amod |
saturating,concentration |
R1748 |
T2782 |
T2775 |
conj |
concentration,concentration |
R1749 |
T2783 |
T2782 |
prep |
of,concentration |
R1750 |
T2784 |
T2785 |
compound |
glucose,substrate |
R1751 |
T2785 |
T2783 |
pobj |
substrate,of |
R1752 |
T2786 |
T2782 |
punct |
", ",concentration |
R1753 |
T2787 |
T2782 |
cc |
and,concentration |
R1754 |
T2788 |
T2789 |
amod |
increasing,concentrations |
R1755 |
T2789 |
T2782 |
conj |
concentrations,concentration |
R1756 |
T2790 |
T2789 |
prep |
of,concentrations |
R1757 |
T2791 |
T2790 |
pobj |
LD,of |
R1758 |
T2792 |
T2756 |
punct |
.,evaluated |
R1759 |
T2794 |
T2795 |
mark |
As,shown |
R1760 |
T2795 |
T2796 |
advcl |
shown,reversed |
R1761 |
T2797 |
T2795 |
prep |
in,shown |
R1762 |
T2798 |
T2799 |
compound |
Figure,2C |
R1763 |
T2799 |
T2797 |
pobj |
2C,in |
R1764 |
T2800 |
T2796 |
punct |
", ",reversed |
R1765 |
T2801 |
T2802 |
det |
the,domain |
R1766 |
T2802 |
T2796 |
nsubj |
domain,reversed |
R1767 |
T2803 |
T2802 |
compound |
LD,domain |
R1768 |
T2804 |
T2796 |
advmod |
sharply,reversed |
R1769 |
T2805 |
T2806 |
det |
the,effect |
R1770 |
T2806 |
T2796 |
dobj |
effect,reversed |
R1771 |
T2807 |
T2806 |
amod |
inhibitory,effect |
R1772 |
T2808 |
T2806 |
prep |
of,effect |
R1773 |
T2809 |
T2808 |
pobj |
Cox11,of |
R1774 |
T2810 |
T2806 |
prep |
on,effect |
R1775 |
T2811 |
T2812 |
compound |
HKI,activity |
R1776 |
T2812 |
T2810 |
pobj |
activity,on |
R1777 |
T2813 |
T2796 |
prep |
in,reversed |
R1778 |
T2814 |
T2815 |
det |
a,manner |
R1779 |
T2815 |
T2813 |
pobj |
manner,in |
R1780 |
T2816 |
T2817 |
npadvmod |
concentration,dependent |
R1781 |
T2817 |
T2815 |
amod |
dependent,manner |
R1782 |
T2818 |
T2817 |
punct |
-,dependent |
R1783 |
T2819 |
T2796 |
punct |
", ",reversed |
R1784 |
T2820 |
T2796 |
cc |
but,reversed |
R1785 |
T2821 |
T2822 |
prep |
under,reach |
R1786 |
T2822 |
T2796 |
conj |
reach,reversed |
R1787 |
T2823 |
T2824 |
amod |
saturating,amounts |
R1788 |
T2824 |
T2821 |
pobj |
amounts,under |
R1789 |
T2825 |
T2823 |
punct |
(,saturating |
R1790 |
T2826 |
T2823 |
cc |
and,saturating |
R1791 |
T2827 |
T2823 |
conj |
stochiometric,saturating |
R1792 |
T2828 |
T2824 |
punct |
),amounts |
R1793 |
T2829 |
T2824 |
prep |
of,amounts |
R1794 |
T2830 |
T2829 |
pobj |
LD,of |
R1795 |
T2831 |
T2822 |
punct |
", ",reach |
R1796 |
T2832 |
T2833 |
det |
the,velocity |
R1797 |
T2833 |
T2822 |
nsubj |
velocity,reach |
R1798 |
T2834 |
T2833 |
prep |
of,velocity |
R1799 |
T2835 |
T2836 |
det |
the,reaction |
R1800 |
T2836 |
T2834 |
pobj |
reaction,of |
R1801 |
T2837 |
T2822 |
aux |
did,reach |
R1802 |
T2838 |
T2822 |
neg |
not,reach |
R1803 |
T2839 |
T2822 |
dobj |
that,reach |
R1804 |
T2840 |
T2839 |
acl |
observed,that |
R1805 |
T2841 |
T2840 |
prep |
for,observed |
R1806 |
T2842 |
T2843 |
compound |
HKI,activity |
R1807 |
T2843 |
T2841 |
pobj |
activity,for |
R1808 |
T2844 |
T2840 |
prep |
in,observed |
R1809 |
T2845 |
T2846 |
det |
the,absence |
R1810 |
T2846 |
T2844 |
pobj |
absence,in |
R1811 |
T2847 |
T2846 |
prep |
of,absence |
R1812 |
T2848 |
T2847 |
pobj |
Cox11,of |
R1813 |
T2849 |
T2850 |
punct |
(,2A |
R1814 |
T2850 |
T2840 |
parataxis |
2A,observed |
R1815 |
T2851 |
T2850 |
compound |
Figure,2A |
R1816 |
T2852 |
T2850 |
punct |
),2A |
R1817 |
T2853 |
T2822 |
punct |
", ",reach |
R1818 |
T2854 |
T2822 |
advcl |
suggesting,reach |
R1819 |
T2855 |
T2856 |
det |
the,LD |
R1820 |
T2856 |
T2857 |
nsubj |
LD,have |
R1821 |
T2857 |
T2854 |
advcl |
have,suggesting |
R1822 |
T2858 |
T2857 |
prep |
by,have |
R1823 |
T2859 |
T2858 |
pobj |
itself,by |
R1824 |
T2860 |
T2857 |
aux |
may,have |
R1825 |
T2861 |
T2857 |
advmod |
also,have |
R1826 |
T2862 |
T2863 |
det |
an,effect |
R1827 |
T2863 |
T2857 |
dobj |
effect,have |
R1828 |
T2864 |
T2863 |
prep |
on,effect |
R1829 |
T2865 |
T2866 |
compound |
HKI,activity |
R1830 |
T2866 |
T2864 |
pobj |
activity,on |
R1831 |
T2867 |
T2822 |
punct |
.,reach |
R1832 |
T2869 |
T2870 |
advmod |
Indeed,reduced |
R1833 |
T2871 |
T2870 |
punct |
", ",reduced |
R1834 |
T2872 |
T2873 |
det |
a,concentration |
R1835 |
T2873 |
T2870 |
nsubj |
concentration,reduced |
R1836 |
T2874 |
T2873 |
compound |
saturating,concentration |
R1837 |
T2875 |
T2873 |
prep |
of,concentration |
R1838 |
T2876 |
T2875 |
pobj |
LD,of |
R1839 |
T2877 |
T2878 |
det |
the,V max |
R1840 |
T2878 |
T2870 |
dobj |
V max,reduced |
R1841 |
T2879 |
T2878 |
cc |
but,V max |
R1842 |
T2880 |
T2879 |
neg |
not,but |
R1843 |
T2881 |
T2882 |
det |
the,K m |
R1844 |
T2882 |
T2878 |
conj |
K m,V max |
R1845 |
T2883 |
T2878 |
prep |
of,V max |
R1846 |
T2884 |
T2883 |
pobj |
HKI,of |
R1847 |
T2885 |
T2886 |
punct |
(,2D |
R1848 |
T2886 |
T2878 |
parataxis |
2D,V max |
R1849 |
T2887 |
T2886 |
compound |
Figure,2D |
R1850 |
T2888 |
T2886 |
punct |
),2D |
R1851 |
T2889 |
T2870 |
prep |
by,reduced |
R1852 |
T2890 |
T2891 |
punct |
~,20 |
R1853 |
T2891 |
T2892 |
nummod |
20,% |
R1854 |
T2892 |
T2889 |
pobj |
%,by |
R1855 |
T2893 |
T2870 |
prep |
under,reduced |
R1856 |
T2894 |
T2895 |
amod |
similar,conditions |
R1857 |
T2895 |
T2893 |
pobj |
conditions,under |
R1858 |
T2896 |
T2870 |
punct |
.,reduced |