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blood pressure could conceivably be higher in mice with elevated tail bleeding time, several studies suggest that this is not the case. Studies of A/J [33-36] mice have reported either decreased blood pressure or no difference compared to the B6 mice. Blood pressure was measured in the Plg-/- mice (D. Hellard, J. Hoover-Plow, and E. Plow, unpublished results), and these mice have reduced blood pressure when compared to WT littermates, and uPA-/- [37] and Lepob [38,39] mice also have reduced blood pressure, but there is no correspondence between blood pressure and tail bleeding or rebleeding times. Morphometric analysis of the tail indicated a difference in the collagen content of the tail in the A/J mice. Differences in the structure and/or metabolism of collagen or extracellular matrix proteins may contribute to the increased rebleeding and reduced occlusion time in the A/J mice and warrant further investigation."}

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